Hub : Genes

LOC134485263

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC134485263	0.08	0.05	1.3e-04	0.04	0.04	0.04	0.04	7.1e-05	6.6e-05	8.5e-05	8.6e-05
2	NAcc	gene expression	LOC134485263	0.04	0.03	4.3e-05	0.03	0.03	0.02	0.02	7.0e-05	7.5e-05	1.4e-04	1.2e-04
3	pVTA	gene expression	LOC134485263	0.11	0.07	2.2e-06	0.09	0.07	0.07	0.08	1.3e-07	4.2e-06	3.2e-06	6.0e-07
4	Brain	gene expression	LOC134485263	0.06	0.04	9.0e-05	0.06	0.04	0.04	0.05	4.3e-06	6.9e-05	1.2e-04	8.6e-06
5	OFC	gene expression	LOC134485263	0.2	0.13	5.6e-03	0.13	0.11	0.08	0.12	6.1e-04	1.2e-03	6.5e-03	8.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	2.3	4.3	4.7	-2.1	2.1	2.1	1.9	2.2
Area under the delay curve	0.3	0.4	0.5	-0.7	0.5	0.5	0.6	0.7
BMI with tail	3.4	11.9	14.0	-3.7	3.6	3.6	3.2	3.0
BMI without tail	0.9	4.8	6.2	-2.5	2.4	2.4	1.8	1.7
Body weight	5.1	22.3	25.6	-5.1	5.0	4.9	4.5	4.0
Weight adjusted by age	0.1	0.3	0.7	-0.5	0.3	0.4	0.6	0.8
Bone surface	1.2	2.3	2.5	-1.5	1.5	1.6	1.4	1.6
Bone volume	1.7	3.4	3.7	-1.9	1.8	1.8	1.8	1.9
Breakpoint value in progressive ratio session	1.3	2.3	3.4	-1.8	1.6	1.7	1.2	1.1
Number of licking bursts	0.3	1.0	1.2	-0.9	1.0	1.0	1.1	1.1
Context. condit. distance diff. score	0.5	0.6	1.0	0.8	-0.7	-0.7	-1.0	-0.7
Locomotion velocity, session 1	0.2	0.2	0.5	0.3	-0.3	-0.3	-0.5	-0.7
Locomotion distance, session 1	1.7	2.1	2.3	1.5	-1.5	-1.5	-1.5	-1.4
Locomotion velocity, session 2	3.0	3.6	4.0	1.9	-1.8	-1.8	-1.8	-2.0
Locomotion distance, session 2	1.1	1.6	1.9	1.4	-1.3	-1.3	-1.2	-1.1
Locomotion velocity, session 3	1.1	1.3	1.8	1.2	-1.1	-1.1	-0.9	-1.4
Locomotion distance, session 3	2.6	2.9	3.1	1.8	-1.7	-1.7	-1.7	-1.7
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.3	-0.4	-0.4	-0.2	0.1
Stereotopy head waving duration, day 3	0.1	0.1	0.4	-0.2	0.2	0.2	0.2	0.7
Locomotion velocity, session 7	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.3	-0.0
Locomotion distance, session 7	0.7	0.9	1.1	1.1	-1.0	-1.0	-0.9	-0.5
Stereotopy head waving bouts, day 7	0.1	0.1	0.1	-0.3	0.3	0.3	0.4	-0.1
Stereotopy head waving duration, day 7	0.8	1.0	1.2	-1.1	1.0	1.0	1.1	0.6
Locomotion velocity, session 8	0.4	0.5	0.7	0.7	-0.5	-0.5	-0.8	-0.9
Locomotion distance, session 8	2.1	3.0	3.5	1.9	-1.6	-1.6	-1.8	-1.7
Degree of sensitization distance	1.0	1.1	1.7	-1.0	1.0	1.0	1.0	1.3
Degree of sensitization stereotypy	0.7	0.8	1.0	-0.9	1.0	1.0	0.9	0.2
Conditioned locomotion	0.0	0.0	0.1	-0.1	0.2	0.2	0.3	-0.1
Cocaine response after cond. corrected	5.5	8.2	8.6	2.9	-2.9	-2.9	-2.9	-2.6
Cocaine response after cond. not corrected	4.3	6.2	6.6	2.6	-2.6	-2.5	-2.5	-2.3
Cocaine response before conditioning	1.2	1.4	1.7	-1.2	1.2	1.3	1.3	0.9
Saline control response	0.8	1.1	1.7	0.9	-0.9	-0.9	-1.0	-1.3
Bone: connectivity density	1.1	1.8	2.0	-1.3	1.4	1.3	1.2	1.3
Bone: cortical apparent density	4.6	7.3	7.5	2.7	-2.7	-2.7	-2.7	-2.6
Bone: cortical area	2.4	4.0	4.7	-1.9	1.9	1.8	2.2	2.2
Bone: cortical porosity	0.5	0.5	0.7	-0.8	0.8	0.8	0.8	0.5
Bone: cortical porosity	1.8	2.0	2.2	-1.5	1.5	1.5	1.4	1.2
Bone: cortical thickness	0.2	0.3	0.6	-0.4	0.5	0.4	0.8	0.7
Bone: cortical thickness	0.0	0.0	0.0	0.1	-0.2	0.0	-0.1	0.1
Bone: cortical tissue density	4.5	7.2	7.4	2.7	-2.6	-2.7	-2.7	-2.6
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.3	-0.5
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.1
Condit. Reinf. active responses	0.1	0.1	0.1	-0.2	0.3	0.3	0.3	0.1
Condit. Reinf. inactive responses	0.3	0.5	0.5	-0.6	0.7	0.7	0.7	0.7
Incentive salience index mean	0.4	0.6	0.9	0.8	-0.7	-0.7	-0.6	-1.0
Condit. Reinf. lever presses	0.3	0.5	0.7	0.7	-0.7	-0.7	-0.5	-0.8
Condit. Reinf. active minus inactive responses	2.2	3.3	4.6	-1.8	1.7	1.7	1.6	2.1
Condit. Reinf. active-inactive response ratio	0.9	1.5	2.4	-1.2	1.1	1.1	1.1	1.6
Condit. Reinf. active responses	3.4	4.9	5.3	-2.3	2.2	2.2	2.1	2.3
Condit. Reinf. inactive responses	1.2	1.8	2.1	-1.4	1.4	1.5	1.4	1.1
Condit. Reinf. lever presses	1.0	1.5	1.6	-1.3	1.3	1.3	1.0	1.2
Condit. Reinf. lever reinforcers received	2.6	3.6	3.9	-1.9	1.9	1.9	1.8	2.0
Conditioned reinforcement - actives	0.7	2.6	3.0	1.7	-1.7	-1.6	-1.6	-1.5
Conditioned reinforcement - inactives	0.1	0.3	0.5	-0.6	0.5	0.7	0.4	0.1
Conditioned locomotion	2.7	4.0	4.8	2.2	-2.1	-2.0	-2.1	-1.7
Patch foraging indifference point 0 sec	0.3	0.8	1.0	-0.9	0.9	0.9	1.0	0.9
Patch foraging indifference point AUC	0.4	1.0	1.3	-1.0	1.1	0.9	0.9	0.9
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	0.5	-0.6	-0.6	-0.2	0.0
Delay disc. indifference point, 16s delay	0.2	0.3	0.4	-0.6	0.5	0.5	0.5	0.4
Delay disc. indifference point, 2s delay	0.5	0.5	0.6	0.6	-0.8	-0.8	-0.8	-0.6
Delay disc. indifference point, 24s delay	0.6	0.9	1.2	-1.1	1.0	1.0	0.9	0.8
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.4	0.2	0.2	-0.1	-0.1
Delay disc. indifference point, 8s delay	0.3	0.5	0.9	-0.7	0.5	0.5	0.8	1.0
Indifference point function ln k	0.1	0.3	0.4	0.6	-0.7	-0.5	-0.6	-0.4
Indifference point function log k	0.1	0.3	0.4	0.6	-0.7	-0.5	-0.6	-0.4
Patch foraging total patch changes 0 sec	0.4	1.2	1.4	-1.1	1.1	1.1	1.2	1.1
Patch foraging total patch changes 12 sec	1.2	1.6	2.0	-1.2	1.3	1.3	1.4	1.2
Patch foraging total patch changes 18 sec	1.6	3.9	4.5	-2.0	2.1	1.7	2.1	1.9
Patch foraging total patch changes 24 sec	0.7	2.6	3.2	-1.5	1.6	1.4	1.6	1.8
Patch foraging total patch changes 6 sec	1.5	2.5	2.6	-1.5	1.6	1.6	1.6	1.6
Patch foraging time to switch 0 sec	0.1	0.4	0.5	0.6	-0.6	-0.7	-0.7	-0.4
Patch foraging water rate 0 sec	0.1	0.5	0.7	-0.7	0.7	0.7	0.8	0.6
Patch foraging water rate 12 sec	0.6	2.3	3.3	-1.4	1.4	1.3	1.7	1.8
Patch foraging water rate 18 sec	0.1	0.3	0.4	0.6	-0.6	-0.6	-0.5	-0.3
Patch foraging water rate 24 sec	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.4	-0.2
Patch foraging water rate 6 sec	0.0	0.0	0.0	-0.0	-0.0	-0.1	-0.2	-0.1
Seeking ratio, delayed vs. immediate footshock	1.4	2.0	2.6	1.6	-1.3	-1.3	-1.5	-1.3
Distance traveled before self-admin	3.0	6.5	7.6	2.6	-2.5	-2.8	-2.5	-2.3
Distance traveled after self-admin	2.3	4.0	5.4	1.8	-1.7	-1.8	-2.3	-2.2
Extensor digitorum longus weight	1.0	4.0	4.2	-2.1	1.9	2.0	2.0	1.9
Bone: elastic displacement	0.1	0.1	0.2	0.3	-0.4	-0.4	-0.2	-0.2
Bone: elastic work	0.7	0.9	1.1	1.0	-1.0	-1.0	-0.9	-0.8
Bone: endosteal estimation	0.8	2.0	3.0	-1.4	1.3	1.4	1.3	1.7
Bone: endosteal perimeter	1.0	2.4	3.4	-1.6	1.5	1.4	1.5	1.8
Epididymis fat weight	7.2	36.5	41.2	-6.4	6.3	6.2	6.0	5.3
Delta time in closed arm before/after self-admin	1.1	1.0	1.3	1.1	-1.1	-0.9	-0.9	-1.0
Delta time in open arm before/after self-admin	4.0	4.7	5.2	-2.3	2.2	2.1	2.1	2.1
Diff in mean of infusions in LGA sessions	0.5	0.8	1.2	-1.1	1.0	1.1	0.7	0.6
Delay discount exponential model param	0.2	0.3	0.5	0.7	-0.5	-0.5	-0.5	-0.6
Extinction: sum of active levers before priming	0.7	1.0	2.0	-1.4	1.1	1.2	0.4	0.5
Active lever presses in extinction session 6	0.2	0.3	0.5	-0.7	0.6	0.6	0.1	-0.1
Bone: final force	0.5	0.9	1.0	-0.9	0.9	0.9	1.0	1.0
Bone: final moment	0.7	1.1	1.2	-1.0	1.0	1.1	1.0	1.1
Food consumed during 24 hour testing period	0.1	0.2	0.2	0.5	-0.4	-0.4	-0.3	-0.4
Glucose	1.5	2.4	2.8	-1.7	1.7	1.7	1.5	1.1
Heart weight	1.6	2.6	3.0	-1.7	1.7	1.7	1.7	1.2
Delay discount hyperbolic model param	0.2	0.2	0.4	0.6	-0.4	-0.4	-0.4	-0.4
Intermittent access intake day 1-15 change	0.0	0.2	0.4	0.4	-0.3	-0.7	-0.2	-0.6
Intermittent access intake escalation	0.0	0.1	0.2	0.2	-0.1	-0.4	0.1	-0.3
Intermittent access intake escalation 2	0.2	0.3	0.7	0.5	-0.3	-0.5	-0.4	-0.8
Intermitt. access day 1 inactive lever presses	0.4	5.2	5.6	-2.4	2.2	2.3	2.3	2.1
Intermitt. access day 15 inactive lever presses	0.2	1.0	1.3	-1.0	1.1	0.9	1.1	0.7
Intermitt. access escalation Index	0.0	0.0	0.1	-0.0	-0.0	0.2	0.2	-0.4
Intermittent access day 1 total infusions	0.0	0.1	0.2	0.3	-0.4	-0.3	-0.4	-0.5
Intermittent access day 15 total infusions	0.1	0.2	0.6	0.3	-0.2	-0.4	-0.2	-0.8
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.3	0.0	-0.0	-0.2	-0.2	-0.6
Intermittent access total infusions	0.1	0.1	0.4	0.2	-0.1	-0.2	-0.2	-0.6
Intermittent access day 1 locomotion	0.9	1.6	2.0	1.2	-1.4	-1.2	-1.2	-1.3
Intermittent access day 15 total locomotion	0.1	0.5	0.7	-0.8	0.7	0.6	0.7	0.6
Intermittent access total locomotion	1.1	1.3	1.8	1.1	-1.1	-1.1	-1.1	-1.3
Intermittent access standard deviation	0.1	0.5	1.0	-1.0	0.9	0.6	0.5	0.5
Left kidney weight	0.0	0.2	0.3	-0.5	0.6	0.6	0.3	-0.1
Right kidney weight	0.0	0.1	0.3	-0.2	0.2	0.3	-0.1	-0.6
Cocaine induced anxiety	1.2	3.3	4.0	2.0	-1.8	-1.7	-1.7	-1.9
Post-drug Anxiety	0.0	0.0	0.1	0.2	0.0	-0.0	0.3	0.2
Baseline Anxiety	3.3	5.5	5.8	-2.4	2.4	2.1	2.4	2.3
Tail length	0.2	0.9	1.3	-1.1	1.1	1.0	0.9	0.6
Length with tail	1.0	4.6	5.0	-2.2	2.2	2.2	2.2	1.9
Length without tail	2.0	10.6	12.2	-3.2	3.2	3.1	3.5	3.3
Times rat made contact with spout	0.0	0.0	0.2	0.0	0.0	0.0	0.1	-0.5
Lifetime Intake	0.2	0.2	0.4	0.4	-0.4	-0.4	-0.3	-0.6
Liver weight, left	2.1	3.7	4.0	-2.0	2.0	2.0	1.9	1.7
Liver weight, right	0.0	0.1	0.2	-0.2	0.2	0.2	-0.2	-0.5
Locomotor activity	0.0	0.1	0.1	0.2	-0.3	-0.2	0.0	-0.3
Locomotor testing distance	0.7	1.8	2.0	1.4	-1.4	-1.4	-1.2	-1.3
Locomotor testing rearing	0.2	0.8	1.0	0.8	-0.9	-0.9	-0.8	-1.0
Locomotion in novel chamber	1.8	2.4	2.9	1.7	-1.5	-1.5	-1.6	-1.6
Locomotion in novel chamber post-restriction	1.0	3.0	3.5	1.8	-1.7	-1.7	-1.6	-1.9
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.1	0.2	0.2	0.1	-0.1
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.0	0.2	0.1	0.1	-0.0
Time >=10cm from walls, locomotor time 1	0.0	0.1	0.2	0.2	-0.1	-0.1	-0.5	-0.2
Bouts of movement, locomotor time 1	0.9	1.2	1.8	-1.3	1.3	1.3	0.8	0.6
Total resting periods, locomotor time 1	0.4	0.5	0.8	-0.9	0.8	0.9	0.3	0.2
Rest time, locomotor task time 1	0.5	0.8	1.0	1.0	-0.9	-0.8	-0.9	-1.0
Distance moved, locomotor task time 1	0.0	0.1	0.4	-0.3	0.1	0.2	0.4	0.6
Vertical activity count, locomotor time 1	0.0	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.0
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.2	-0.1	-0.1	0.1	0.2
Bouts of movement, locomotor time 2	0.0	0.1	0.2	0.1	-0.2	-0.1	-0.4	-0.3
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.4	-0.2
Rest time, locomotor task time 2	0.1	0.2	0.3	0.4	-0.5	-0.5	-0.4	-0.2
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.2	-0.1	-0.1	0.3	0.5
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.1	-0.1	-0.0	-0.0	0.4
Light reinforcement 1	0.2	0.7	1.3	1.0	-0.8	-1.1	-0.5	-0.7
Light reinforcement 2	0.7	1.6	1.9	1.3	-1.2	-1.2	-1.2	-1.4
Bone: marrow area	0.8	2.1	3.1	-1.4	1.3	1.4	1.3	1.8
Bone: maximum diameter	3.5	7.1	7.7	-2.7	2.6	2.5	2.7	2.8
Bone: maximum force	0.3	0.6	1.0	-0.7	0.7	0.8	0.7	1.0
Bone: maximum moment	0.4	0.8	1.2	-0.8	0.8	0.9	0.8	1.1
Mean time between licks in bursts	0.2	1.3	1.5	-1.2	1.2	1.2	1.1	1.0
Mean num. licks in bursts	0.6	1.7	2.5	1.2	-1.2	-1.2	-1.3	-1.6
Cd content in liver	4.9	5.4	6.3	2.5	-2.4	-2.4	-2.2	-2.1
Co content in liver	2.0	2.3	2.7	1.6	-1.6	-1.6	-1.5	-1.3
Cu content in liver	0.8	0.9	1.2	0.8	-0.9	-0.9	-1.1	-1.0
Fe content in liver	3.1	3.8	5.2	-1.8	1.9	1.9	2.3	1.9
K content in liver	0.1	0.1	0.2	0.0	-0.1	-0.1	-0.2	-0.5
Mg content in liver	0.2	0.2	0.4	0.3	-0.5	-0.4	-0.6	-0.6
Mn content in liver	0.1	0.1	0.2	0.0	-0.1	-0.1	-0.3	-0.5
Na content in liver	0.0	0.0	0.1	-0.3	0.2	0.2	0.3	-0.0
Rb content in liver	0.1	0.2	0.3	-0.5	0.4	0.5	0.3	-0.0
Se content in liver	0.0	0.0	0.1	0.1	0.0	0.0	0.1	-0.2
Sr content in liver	3.2	2.8	3.7	1.6	-1.6	-1.6	-1.6	-1.9
Zn content in liver	2.4	2.8	3.2	1.7	-1.8	-1.8	-1.6	-1.5
Bone: minimum diameter	1.7	3.3	4.7	-1.7	1.7	1.6	1.9	2.2
Time in familiar zone, hab. session 1	0.2	0.2	0.6	0.3	-0.3	-0.3	-0.5	-0.8
Time in novel zone, hab. session 1	1.2	1.3	1.9	-1.0	1.1	1.1	1.2	1.4
Total zone transitions, hab. session 1	0.1	0.2	0.3	0.4	-0.4	-0.4	-0.3	-0.6
Total locomotion distance, hab. session 1	0.1	0.2	0.3	-0.4	0.5	0.5	0.4	-0.1
Locomotion velocity, hab. session 1	0.0	0.1	0.1	-0.1	0.3	0.3	0.2	-0.3
Time in familiar zone, hab. session 2	2.2	2.5	3.0	-1.5	1.5	1.5	1.5	1.7
Time in novel zone, hab. session 2	1.7	1.8	2.3	1.3	-1.3	-1.3	-1.3	-1.5
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.4	-0.5	-0.5	-0.3	-0.2
Total locomotion distance, hab. session 2	0.0	0.0	0.0	-0.1	0.2	0.2	-0.0	-0.0
Locomotion velocity, hab. session 2	0.0	0.0	0.0	-0.1	0.1	0.1	-0.0	-0.2
Novel to familiar place preference ratio	0.6	0.7	0.9	-0.8	0.8	0.8	0.8	1.0
Novelty place preference	0.5	0.6	0.7	-0.7	0.8	0.8	0.7	0.8
Time in novel zone, NPP test	1.3	1.5	1.6	-1.2	1.3	1.3	1.2	1.3
Total zone transitions, NPP test	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.2	-0.5
Total locomotion distance, NPP test	0.1	0.1	0.1	0.3	-0.2	-0.2	-0.3	-0.2
Locomotion velocity, NPP test	0.5	0.7	0.8	0.9	-0.8	-0.8	-0.9	-0.8
Intraocular pressure	1.9	3.1	3.3	-1.8	1.8	1.8	1.7	1.7
Delta distance traveled before/after self-admin	0.1	0.1	0.1	-0.4	0.2	0.4	-0.1	-0.4
Delta ambulatory time before/after self-admin	0.2	0.3	0.6	-0.7	0.6	0.8	0.4	0.2
Parametrial fat weight	9.7	22.9	25.8	-5.1	4.8	4.9	4.9	4.3
Pavlov. Cond. lever latency	0.4	0.5	0.7	-0.8	0.7	0.7	0.5	0.8
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.0	-0.1	-0.1	0.2	0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.0	-0.3
Pavlov. Cond. index score	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.0	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.2	-0.2	-0.2	-0.1	-0.5
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.1	-0.0	-0.0	-0.2	-0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.3	-0.2	-0.2	-0.3	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.2	-0.0
Pavlov. Cond. response bias	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.1	-0.3
Pavlov. Cond. lever latency	1.6	2.2	2.7	1.5	-1.6	-1.6	-1.4	-1.2
Pavlov. Cond. magazine entry latency	1.0	1.4	1.6	-1.3	1.2	1.3	1.2	1.1
Pavlov. Cond. change in total contacts	0.7	1.8	2.2	-1.3	1.3	1.4	1.2	1.5
Pavlov. Cond. index score	1.4	2.2	2.6	-1.6	1.5	1.6	1.4	1.3
Pavlov. Cond. latency score	1.2	2.0	2.2	-1.4	1.4	1.5	1.3	1.3
Pavlov. Cond. lever contacts	0.8	1.1	1.5	-1.1	1.1	1.2	1.0	0.8
Pavlov. Cond. magazine entry number	0.9	1.2	1.3	1.1	-1.0	-1.1	-1.0	-1.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	-0.1	0.1	0.1	0.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.7	2.0	-1.4	1.3	1.4	1.2	1.1
Pavlov. Cond. response bias	1.8	2.4	3.1	-1.6	1.6	1.7	1.5	1.3
Time in closed arm before self-admin	0.1	0.1	0.3	0.2	-0.3	-0.3	-0.3	-0.6
Time in closed arm after self-admin	2.0	2.2	2.5	1.5	-1.6	-1.4	-1.5	-1.6
Time in open arm before self-admin	0.2	0.3	0.6	0.8	-0.6	-0.5	-0.5	-0.1
Time in open arm after self-admin	1.9	2.1	2.3	-1.4	1.5	1.4	1.5	1.4
Bone: periosteal estimation	1.5	3.5	4.8	-1.7	1.7	1.7	1.9	2.2
Bone: periosteal perimeter	2.4	4.8	5.4	-2.2	2.1	2.0	2.3	2.3
Bone: post-yield work	0.6	1.0	1.3	-0.9	0.9	1.0	1.0	1.1
Progressive ratio test 1 active lever presses	0.4	0.7	1.0	0.7	-0.8	-0.7	-0.8	-1.0
Progressive ratio test 1 breakpoint	0.4	0.7	1.1	0.7	-0.8	-0.7	-0.8	-1.1
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.4	-0.5	0.5	0.7	0.5	-0.1
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.1	0.0	-0.1	-0.1	-0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.2	0.1	-0.0	-0.1	-0.2
Progressive ratio test 2 inactive lever presses	0.2	0.5	0.8	-0.5	0.6	0.7	0.9	0.8
Incentive Sensitization - Responses	0.1	0.4	0.6	-0.8	0.7	0.6	0.4	0.6
Incentive Sensitization - Breakpoint	0.2	0.5	0.8	-0.9	0.8	0.7	0.5	0.6
Sum of active levers in priming session hrs 5-6	0.9	0.8	1.5	-1.2	1.1	1.1	0.5	0.2
Progressive ratio	0.1	0.2	0.3	0.6	-0.4	-0.4	-0.3	0.2
Food seeking constrained by brief footshock	0.0	0.1	0.1	0.2	-0.2	-0.2	0.1	0.3
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	0.1	-0.3	-0.3	-0.1	-0.4
Retroperitoneal fat weight	9.7	43.3	48.6	-7.0	6.7	6.8	6.5	5.9
Reaction time number correct	0.2	0.6	0.9	-0.8	0.6	0.6	0.9	0.7
Reaction time mean minus median	0.0	0.3	0.5	-0.7	0.7	0.4	0.4	0.2
Reaction time mean minus median AUC	0.0	0.2	0.4	-0.0	-0.0	-0.4	-0.5	-0.6
Reaction time num false alarms	0.3	0.5	0.6	0.7	-0.7	-0.7	-0.8	-0.5
Reaction time num false alarms AUC	0.4	0.8	1.1	0.9	-0.9	-0.9	-1.0	-0.8
Reaction time trials correct on left	0.2	0.6	0.9	-0.8	0.6	0.6	0.9	0.7
Reaction time trials on left	0.2	0.7	1.0	-0.9	0.7	0.7	1.0	0.7
Reaction time mean	0.0	0.0	0.1	-0.1	-0.2	-0.3	-0.2	-0.1
Reaction time mean AUC	0.0	0.1	0.2	0.0	-0.2	-0.4	-0.4	-0.2
Median of all reaction times	0.2	0.2	0.4	0.3	-0.6	-0.6	-0.5	-0.3
Reaction time omissions	1.3	2.1	2.8	-1.7	1.5	1.5	1.5	1.0
Reaction time false alarm rate	0.6	0.9	1.2	1.0	-0.9	-0.8	-1.1	-0.7
Reaction time premature initiation rate	0.5	0.8	1.5	0.8	-0.8	-0.8	-0.9	-1.2
Reaction time premature initiations	0.1	0.2	0.7	0.2	-0.4	-0.4	-0.4	-0.9
Std. dev. reaction times	0.2	0.5	1.0	-1.0	0.9	0.6	0.6	0.5
Reaction time trials completed	0.2	0.7	1.0	-0.9	0.7	0.7	1.0	0.7
Reaction time trials AUC	0.2	0.6	0.9	-0.9	0.7	0.7	0.9	0.7
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.5	0.4	0.6	-0.0	0.2
Run reversals in cocaine runway, males	1.0	1.1	1.2	1.0	-1.1	-1.1	-0.9	-1.1
Latency to leave start box in cocaine runway	0.0	0.1	0.2	-0.4	0.1	0.2	-0.1	0.2
Latency to leave start box in cocaine runway, F	0.1	0.2	0.4	-0.6	0.4	0.5	0.1	0.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.2	-0.4	-0.4	-0.2	0.3
Std. dev. time between licks in bursts	0.0	0.1	0.2	-0.2	0.3	0.3	0.1	0.5
Total sessions with >9 infusions	0.3	0.4	0.6	0.8	-0.8	-0.7	-0.3	-0.3
Short access day 1 total inactive lever presses	0.2	0.3	0.6	-0.4	0.4	0.8	0.6	0.5
Short access day 10 total inactive lever presses	0.0	0.2	0.3	-0.5	0.2	0.6	0.4	0.2
Short access day 1 total infusions	0.2	0.4	0.6	0.5	-0.7	-0.4	-0.5	-0.8
Short access day 10 total infusions	1.4	2.3	2.5	1.6	-1.5	-1.5	-1.6	-1.5
Short access total infusions	0.8	1.2	1.4	1.2	-1.1	-1.1	-0.9	-1.1
Short access day 1 locomotion	0.1	0.2	0.6	0.2	-0.4	-0.2	-0.4	-0.8
Short access day 10 total locomotion	0.3	1.1	1.9	1.0	-1.4	-1.0	-0.9	-0.7
Short access total locomotion	1.8	2.7	3.4	1.7	-1.9	-1.7	-1.5	-1.3
One hour access (0.3 mA shock)	1.0	1.2	1.4	-1.2	1.1	1.1	1.1	0.9
Compulsive drug intake	1.0	1.5	2.0	-1.3	0.9	1.4	1.4	1.0
One hour access (shock baseline)	0.1	0.2	0.3	0.4	-0.1	-0.5	-0.5	-0.5
Social response proportion	0.7	0.8	1.4	0.8	-0.9	-0.5	-1.0	-1.2
Social responses	0.6	0.8	0.9	-0.9	0.8	0.9	0.9	0.8
Social time	0.1	0.2	0.3	0.4	-0.5	-0.4	-0.5	-0.6
Soleus weight	0.0	0.0	0.2	-0.4	0.1	0.2	0.0	-0.1
Bone: stiffness	0.3	0.6	0.7	-0.7	0.7	0.7	0.8	0.8
Tibialis anterior weight	0.7	2.5	2.7	-1.6	1.5	1.6	1.6	1.5
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.0	0.2	0.2	0.4	0.5
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.2	-0.2	0.4	0.3	0.2	0.2
Time to tail flick, test, before self-admin	4.1	4.7	6.6	2.0	-2.0	-1.9	-2.3	-2.6
Time to tail flick, test, after self-admin	0.6	0.7	0.8	-0.8	0.8	0.9	0.8	0.7
Delta time to tail flick, vehicle, before/after SA	0.8	0.9	1.3	-1.1	1.0	0.9	0.8	0.7
Delta time to tail flick, test, before/after SA	1.5	1.8	2.1	-1.2	1.3	1.3	1.4	1.5
Tibia length	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.1	-0.3
Ambulatory time before self-admin	1.4	4.3	5.2	2.2	-2.0	-2.3	-2.1	-1.8
Ambulatory time after self-admin	1.5	2.4	3.6	1.4	-1.3	-1.3	-1.8	-1.9
Bone: tissue strength	0.0	0.0	0.1	-0.2	0.3	0.2	0.1	0.1
Total heroin consumption	2.1	2.5	3.9	-2.0	1.8	1.7	1.2	1.0
Bone: trabecular number	2.4	4.4	4.7	-2.1	2.2	2.2	2.0	2.1
Bone: trabecular spacing	0.2	0.2	0.4	0.5	-0.5	-0.7	-0.3	-0.3
Bone: trabecular thickness	2.6	3.6	3.8	-1.9	1.9	2.0	1.8	1.9
Bone: trabecular tissue density	1.2	2.0	2.4	1.4	-1.4	-1.6	-1.5	-1.2
Water consumed over 24 hours	0.2	0.5	0.7	0.7	-0.6	-0.6	-0.5	-0.8
Number of responses in last shaping day	0.5	0.6	1.5	0.6	-0.4	-0.5	-0.9	-1.2