Hub : Genes

LOC134485226

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression LOC134485226 0.04 0.02 2.9e-04 0.04 0.04 0.04 0.04 4.7e-05 9.6e-05 1.2e-04 9.4e-05
2 NAcc gene expression LOC134485226 0.02 0.01 3.7e-03 0 0.01 0 0 8.0e-02 8.7e-03 2.7e-01 6.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density9.016.518.2-3.94.3
Area under the delay curve0.60.91.3-1.10.7
BMI with tail0.10.20.2-0.50.4
BMI without tail0.00.20.5-0.70.1
Body weight0.83.54.1-2.01.7
Weight adjusted by age0.20.50.8-0.40.9
Bone surface5.711.211.9-3.23.4
Bone volume6.412.713.9-3.43.7
Breakpoint value in progressive ratio session0.00.00.0-0.10.0
Number of licking bursts2.26.67.22.7-2.5
Context. condit. distance diff. score2.22.72.9-1.71.6
Locomotion velocity, session 13.13.43.92.0-1.7
Locomotion distance, session 10.50.60.80.9-0.7
Locomotion velocity, session 21.31.51.61.3-1.2
Locomotion distance, session 21.52.12.31.5-1.4
Locomotion velocity, session 30.00.00.00.00.0
Locomotion distance, session 30.00.00.0-0.20.0
Stereotopy head waving bouts, day 30.40.50.6-0.80.7
Stereotopy head waving duration, day 30.70.91.1-1.00.9
Locomotion velocity, session 70.80.91.0-1.00.9
Locomotion distance, session 70.91.11.2-1.11.0
Stereotopy head waving bouts, day 70.00.00.10.1-0.3
Stereotopy head waving duration, day 70.00.00.0-0.20.1
Locomotion velocity, session 80.00.00.1-0.10.3
Locomotion distance, session 80.10.10.1-0.40.3
Degree of sensitization distance0.20.20.3-0.50.4
Degree of sensitization stereotypy0.00.00.0-0.1-0.0
Conditioned locomotion0.20.30.3-0.40.6
Cocaine response after cond. corrected0.60.81.1-1.00.8
Cocaine response after cond. not corrected0.91.31.8-1.30.9
Cocaine response before conditioning0.10.10.2-0.5-0.1
Saline control response3.24.46.0-2.51.7
Bone: connectivity density6.09.69.8-3.13.1
Bone: cortical apparent density0.10.10.20.0-0.4
Bone: cortical area2.64.34.6-2.02.1
Bone: cortical porosity0.10.10.10.4-0.4
Bone: cortical porosity0.00.00.00.2-0.2
Bone: cortical thickness0.30.50.6-0.80.6
Bone: cortical thickness0.00.00.0-0.1-0.2
Bone: cortical tissue density0.10.10.20.1-0.5
Condit. Reinf. active minus inactive responses0.91.11.21.0-1.1
Condit. Reinf. active-inactive response ratio1.81.92.01.4-1.4
Condit. Reinf. active responses0.10.20.3-0.50.3
Condit. Reinf. inactive responses2.73.43.9-2.01.7
Incentive salience index mean0.91.11.40.9-1.2
Condit. Reinf. lever presses0.60.91.40.7-1.2
Condit. Reinf. active minus inactive responses0.20.30.3-0.50.5
Condit. Reinf. active-inactive response ratio0.00.00.00.00.1
Condit. Reinf. active responses1.92.83.0-1.71.6
Condit. Reinf. inactive responses1.62.32.7-1.61.4
Condit. Reinf. lever presses0.10.20.2-0.30.5
Condit. Reinf. lever reinforcers received1.21.71.9-1.41.3
Conditioned reinforcement - actives1.03.94.7-2.21.7
Conditioned reinforcement - inactives2.97.910.4-3.22.3
Conditioned locomotion1.92.83.3-1.81.5
Patch foraging indifference point 0 sec0.10.40.40.5-0.7
Patch foraging indifference point AUC0.20.40.8-0.90.1
Delay disc. indifference point, 0s delay1.11.31.7-1.30.9
Delay disc. indifference point, 16s delay1.72.32.8-1.71.4
Delay disc. indifference point, 2s delay0.91.01.3-1.10.9
Delay disc. indifference point, 24s delay0.30.40.8-0.90.0
Delay disc. indifference point, 4s delay0.80.81.2-1.10.7
Delay disc. indifference point, 8s delay0.00.10.1-0.1-0.3
Indifference point function ln k0.00.10.10.30.2
Indifference point function log k0.00.10.10.30.2
Patch foraging total patch changes 0 sec0.10.20.30.4-0.6
Patch foraging total patch changes 12 sec0.20.20.40.2-0.6
Patch foraging total patch changes 18 sec0.00.10.1-0.4-0.1
Patch foraging total patch changes 24 sec0.00.10.20.2-0.4
Patch foraging total patch changes 6 sec0.10.20.40.2-0.7
Patch foraging time to switch 0 sec1.24.65.92.4-1.8
Patch foraging water rate 0 sec0.20.81.0-1.00.8
Patch foraging water rate 12 sec0.00.00.00.00.0
Patch foraging water rate 18 sec0.00.10.2-0.10.4
Patch foraging water rate 24 sec1.21.81.9-1.41.3
Patch foraging water rate 6 sec0.00.00.1-0.20.2
Seeking ratio, delayed vs. immediate footshock0.10.10.30.1-0.5
Distance traveled before self-admin0.00.10.10.4-0.2
Distance traveled after self-admin1.62.83.7-1.41.9
Extensor digitorum longus weight0.41.52.0-1.41.0
Bone: elastic displacement2.02.52.71.7-1.5
Bone: elastic work0.50.60.90.9-0.6
Bone: endosteal estimation4.611.112.5-3.13.5
Bone: endosteal perimeter2.97.29.2-2.33.0
Epididymis fat weight0.84.24.4-2.02.1
Delta time in closed arm before/after self-admin5.14.84.82.2-2.2
Delta time in open arm before/after self-admin2.02.32.7-1.41.6
Diff in mean of infusions in LGA sessions0.10.10.20.5-0.3
Delay discount exponential model param0.60.81.21.1-0.6
Extinction: sum of active levers before priming0.20.30.40.6-0.5
Active lever presses in extinction session 61.51.51.5-1.21.2
Bone: final force0.71.11.5-0.91.2
Bone: final moment0.71.11.5-0.81.2
Food consumed during 24 hour testing period0.71.41.81.3-1.0
Glucose0.30.40.60.8-0.5
Heart weight0.00.00.1-0.20.1
Delay discount hyperbolic model param0.50.60.91.0-0.5
Intermittent access intake day 1-15 change0.10.40.5-0.50.7
Intermittent access intake escalation0.10.60.7-0.70.8
Intermittent access intake escalation 20.10.10.10.3-0.3
Intermitt. access day 1 inactive lever presses0.11.31.9-1.40.8
Intermitt. access day 15 inactive lever presses1.89.611.4-3.42.8
Intermitt. access escalation Index0.00.10.20.0-0.5
Intermittent access day 1 total infusions1.64.65.4-2.32.0
Intermittent access day 15 total infusions2.35.76.0-2.42.3
Intermittent access terminal intake (last 3 days)2.13.63.6-1.91.9
Intermittent access total infusions3.03.63.7-1.81.9
Intermittent access day 1 locomotion1.73.03.4-1.81.7
Intermittent access day 15 total locomotion0.62.33.1-1.21.8
Intermittent access total locomotion2.53.03.3-1.61.8
Intermittent access standard deviation0.21.11.5-0.91.2
Left kidney weight0.10.50.6-0.80.7
Right kidney weight0.00.00.1-0.1-0.3
Cocaine induced anxiety0.30.91.0-0.91.0
Post-drug Anxiety1.01.21.5-1.01.2
Baseline Anxiety0.00.10.1-0.10.4
Tail length0.73.85.3-2.31.5
Length with tail1.88.19.7-3.12.5
Length without tail1.57.77.8-2.72.8
Times rat made contact with spout0.50.50.6-0.80.7
Lifetime Intake3.23.94.0-2.02.0
Liver weight, left0.20.30.5-0.50.7
Liver weight, right2.13.73.9-2.01.8
Locomotor activity1.21.92.21.5-1.3
Locomotor testing distance1.02.52.61.6-1.6
Locomotor testing rearing0.00.10.10.3-0.3
Locomotion in novel chamber0.10.20.40.20.6
Locomotion in novel chamber post-restriction0.92.63.0-1.71.5
Fecal boli incidents, locomotor time 10.20.61.1-1.10.4
Change in fecal boli incidents, locomotor task0.50.50.60.8-0.7
Time >=10cm from walls, locomotor time 12.22.73.1-1.81.5
Bouts of movement, locomotor time 10.30.40.40.6-0.6
Total resting periods, locomotor time 10.00.00.00.2-0.2
Rest time, locomotor task time 10.00.10.10.1-0.3
Distance moved, locomotor task time 10.00.00.0-0.20.0
Vertical activity count, locomotor time 10.00.10.10.4-0.2
Time >=10cm from walls, locomotor time 20.51.32.0-1.40.8
Bouts of movement, locomotor time 20.51.51.81.1-1.4
Total resting periods, locomotor time 20.52.12.41.4-1.6
Rest time, locomotor task time 21.01.71.91.4-1.2
Distance moved, locomotor task time 20.71.01.3-1.10.8
Vertical activity count, locomotor time 20.00.10.2-0.40.1
Light reinforcement 10.10.30.4-0.40.6
Light reinforcement 20.51.21.31.1-1.0
Bone: marrow area5.012.213.6-3.33.7
Bone: maximum diameter7.715.617.9-3.64.2
Bone: maximum force1.83.64.4-1.62.1
Bone: maximum moment1.73.14.1-1.52.0
Mean time between licks in bursts0.53.13.41.8-1.6
Mean num. licks in bursts3.08.08.9-3.02.7
Cd content in liver2.93.23.51.9-1.7
Co content in liver0.00.00.0-0.2-0.2
Cu content in liver0.10.10.10.4-0.4
Fe content in liver1.82.32.31.5-1.5
K content in liver0.30.30.30.5-0.5
Mg content in liver0.20.20.20.4-0.4
Mn content in liver1.11.31.41.2-1.1
Na content in liver1.01.11.30.9-1.1
Rb content in liver0.00.00.00.00.2
Se content in liver25.129.730.85.3-5.6
Sr content in liver0.00.00.0-0.10.2
Zn content in liver6.17.18.12.5-2.9
Bone: minimum diameter4.07.78.9-2.53.0
Time in familiar zone, hab. session 10.20.20.3-0.60.4
Time in novel zone, hab. session 11.51.72.11.4-1.1
Total zone transitions, hab. session 10.00.00.00.10.1
Total locomotion distance, hab. session 11.21.72.11.5-1.1
Locomotion velocity, hab. session 11.31.82.01.4-1.2
Time in familiar zone, hab. session 20.10.10.10.3-0.4
Time in novel zone, hab. session 20.00.00.0-0.20.2
Total zone transitions, hab. session 20.81.01.21.1-0.9
Total locomotion distance, hab. session 22.63.34.02.0-1.6
Locomotion velocity, hab. session 22.73.64.32.1-1.7
Novel to familiar place preference ratio1.11.41.5-1.21.1
Novelty place preference1.11.51.5-1.21.2
Time in novel zone, NPP test0.40.50.5-0.70.7
Total zone transitions, NPP test1.21.81.91.4-1.3
Total locomotion distance, NPP test1.72.32.51.6-1.5
Locomotion velocity, NPP test0.81.21.21.1-1.1
Intraocular pressure0.10.10.10.30.3
Delta distance traveled before/after self-admin3.94.35.5-1.82.4
Delta ambulatory time before/after self-admin4.57.78.7-2.63.0
Parametrial fat weight0.81.92.51.1-1.6
Pavlov. Cond. lever latency0.20.30.5-0.40.7
Pavlov. Cond. magazine entry latency2.43.13.11.7-1.8
Pavlov. Cond. change in total contacts2.42.62.91.5-1.7
Pavlov. Cond. index score1.41.82.01.3-1.4
Pavlov. Cond. latency score0.81.01.30.9-1.1
Pavlov. Cond. lever contacts0.60.81.10.7-1.0
Pavlov. Cond. magazine entry number2.73.54.0-2.01.7
Pavlov. Cond. intertrial magazine entries1.61.92.3-1.51.2
Pavlov. Cond. lever-magazine prob. diff.2.12.72.91.6-1.7
Pavlov. Cond. response bias3.34.14.32.1-2.0
Pavlov. Cond. lever latency0.20.30.30.5-0.5
Pavlov. Cond. magazine entry latency1.21.71.71.3-1.3
Pavlov. Cond. change in total contacts0.10.20.4-0.60.3
Pavlov. Cond. index score0.00.00.0-0.10.1
Pavlov. Cond. latency score0.00.00.0-0.20.2
Pavlov. Cond. lever contacts0.10.20.2-0.50.5
Pavlov. Cond. magazine entry number1.31.61.8-1.21.3
Pavlov. Cond. intertrial magazine entries0.40.80.9-0.90.9
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.1-0.1
Pavlov. Cond. response bias0.10.20.20.4-0.4
Time in closed arm before self-admin0.00.10.1-0.3-0.1
Time in closed arm after self-admin1.51.72.11.1-1.5
Time in open arm before self-admin0.50.60.80.9-0.7
Time in open arm after self-admin1.11.21.8-0.81.3
Bone: periosteal estimation5.212.213.8-3.33.7
Bone: periosteal perimeter3.67.18.0-2.52.8
Bone: post-yield work1.73.03.1-1.81.7
Progressive ratio test 1 active lever presses3.25.66.1-2.22.5
Progressive ratio test 1 breakpoint2.95.05.5-2.12.3
Progressive ratio test 1 inactive lever presses2.36.17.9-2.82.1
Progressive ratio test 2 active lever presses5.27.48.2-2.62.9
Progressive ratio test 2 breakpoint6.38.08.9-2.73.0
Progressive ratio test 2 inactive lever presses1.85.86.3-2.52.3
Incentive Sensitization - Responses1.13.23.7-1.61.9
Incentive Sensitization - Breakpoint1.63.74.3-1.82.1
Sum of active levers in priming session hrs 5-60.10.10.10.4-0.4
Progressive ratio0.20.60.70.7-0.8
Food seeking constrained by brief footshock0.00.10.10.3-0.2
Seeking ratio, punishment vs. effort0.00.00.00.10.1
Retroperitoneal fat weight0.00.20.2-0.50.5
Reaction time number correct1.03.63.6-1.91.9
Reaction time mean minus median0.00.20.30.6-0.3
Reaction time mean minus median AUC0.00.10.20.4-0.2
Reaction time num false alarms0.10.30.3-0.50.6
Reaction time num false alarms AUC0.00.00.00.2-0.0
Reaction time trials correct on left1.03.63.6-1.91.9
Reaction time trials on left1.03.43.5-1.91.8
Reaction time mean2.24.84.82.2-2.2
Reaction time mean AUC2.35.65.62.3-2.4
Median of all reaction times3.75.85.92.4-2.4
Reaction time omissions0.10.10.10.3-0.3
Reaction time false alarm rate0.40.50.70.8-0.6
Reaction time premature initiation rate0.10.20.3-0.30.6
Reaction time premature initiations0.92.63.0-1.51.7
Std. dev. reaction times0.41.41.61.3-1.1
Reaction time trials completed1.03.43.5-1.91.8
Reaction time trials AUC0.82.82.9-1.71.6
Run reversals in cocaine runway, females0.00.00.00.2-0.1
Run reversals in cocaine runway, males1.31.41.81.3-1.0
Latency to leave start box in cocaine runway0.81.11.2-1.01.1
Latency to leave start box in cocaine runway, F0.30.30.4-0.60.5
Latency to leave start box in cocaine runway, M0.70.70.9-0.61.0
Std. dev. time between licks in bursts2.85.35.82.4-2.2
Total sessions with >9 infusions0.50.60.8-0.90.6
Short access day 1 total inactive lever presses2.44.75.9-2.41.9
Short access day 10 total inactive lever presses0.32.44.2-2.00.8
Short access day 1 total infusions0.51.01.6-1.30.7
Short access day 10 total infusions0.20.30.4-0.60.3
Short access total infusions1.92.63.4-1.81.4
Short access day 1 locomotion0.00.10.1-0.30.1
Short access day 10 total locomotion0.10.50.70.9-0.5
Short access total locomotion0.10.20.20.5-0.4
One hour access (0.3 mA shock)6.47.68.1-2.72.8
Compulsive drug intake0.91.41.8-1.40.9
One hour access (shock baseline)0.30.81.5-0.41.2
Social response proportion0.00.10.10.00.3
Social responses0.60.81.0-0.81.0
Social time0.30.50.80.4-0.9
Soleus weight1.23.64.0-1.82.0
Bone: stiffness1.42.63.0-1.51.7
Tibialis anterior weight1.34.35.7-2.41.7
Time to tail flick, vehicle, before self-admin0.10.20.30.5-0.2
Time to tail flick, vehicle, after self-admin0.10.10.20.0-0.5
Time to tail flick, test, before self-admin1.11.31.3-1.11.2
Time to tail flick, test, after self-admin0.10.10.2-0.40.0
Delta time to tail flick, vehicle, before/after SA0.91.01.6-1.30.6
Delta time to tail flick, test, before/after SA0.10.20.30.2-0.5
Tibia length0.10.20.2-0.40.4
Ambulatory time before self-admin0.31.01.21.1-0.9
Ambulatory time after self-admin1.82.83.5-1.51.9
Bone: tissue strength0.50.60.80.9-0.6
Total heroin consumption0.80.91.1-1.00.9
Bone: trabecular number5.510.311.0-3.13.3
Bone: trabecular spacing1.42.02.51.2-1.6
Bone: trabecular thickness3.24.45.0-1.92.2
Bone: trabecular tissue density2.23.84.2-1.82.1
Water consumed over 24 hours0.00.00.00.0-0.1
Number of responses in last shaping day1.01.31.7-1.30.9