Hub : Genes

LOC134485107

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC134485107	0.03	0.02	1.6e-06	0.03	0.03	0.03	0.03	3.1e-05	5.0e-06	3.5e-05	4.0e-05
2	BLA	gene expression	LOC134485107	0.05	0.05	6.0e-03	0.02	0.03	0.03	0.03	2.9e-02	8.6e-03	9.8e-03	1.5e-02
3	Adipose	gene expression	LOC134485107	0.06	0.09	8.1e-03	0.01	-0	0	0	4.3e-02	4.0e-01	2.9e-01	1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.0	0.1	0.2	0.3	0.4	-0.1
Area under the delay curve	1.2	1.4	1.6	1.1	1.1	-1.3
BMI with tail	0.1	0.3	0.3	-0.6	-0.5	0.5
BMI without tail	0.6	1.8	2.1	1.3	1.3	-1.4
Body weight	2.6	11.4	11.7	3.4	3.4	-3.3
Weight adjusted by age	0.1	0.1	0.2	-0.4	-0.4	0.1
Bone surface	0.7	1.2	1.6	1.1	1.3	-0.9
Bone volume	0.7	1.2	1.5	1.1	1.2	-1.0
Breakpoint value in progressive ratio session	3.1	3.7	4.1	1.9	1.9	-2.0
Number of licking bursts	3.0	4.9	5.2	-2.2	-2.3	2.2
Context. condit. distance diff. score	0.0	0.0	0.0	-0.1	-0.1	-0.1
Locomotion velocity, session 1	1.0	1.1	1.3	-1.1	-0.9	1.1
Locomotion distance, session 1	0.6	0.7	0.8	0.9	0.9	-0.7
Locomotion velocity, session 2	0.3	0.4	0.5	-0.7	-0.6	0.5
Locomotion distance, session 2	1.5	2.0	2.4	-1.4	-1.4	1.6
Locomotion velocity, session 3	0.4	0.5	0.5	-0.7	-0.7	0.6
Locomotion distance, session 3	4.2	4.6	4.9	2.2	2.1	-2.1
Stereotopy head waving bouts, day 3	1.0	1.2	1.4	-1.1	-1.0	1.2
Stereotopy head waving duration, day 3	2.2	2.6	2.8	-1.7	-1.5	1.6
Locomotion velocity, session 7	0.1	0.2	0.2	0.4	0.5	-0.4
Locomotion distance, session 7	0.1	0.1	0.1	0.4	0.4	-0.3
Stereotopy head waving bouts, day 7	1.3	1.4	1.6	-1.1	-1.3	1.2
Stereotopy head waving duration, day 7	1.8	2.2	2.4	-1.5	-1.6	1.4
Locomotion velocity, session 8	4.2	5.1	5.2	-2.3	-2.2	2.3
Locomotion distance, session 8	0.6	0.9	0.9	-0.9	-0.9	0.9
Degree of sensitization distance	1.2	1.2	1.5	-1.2	-1.0	1.1
Degree of sensitization stereotypy	0.6	0.7	0.9	-0.7	-0.9	0.7
Conditioned locomotion	0.0	0.1	0.1	-0.2	-0.3	0.2
Cocaine response after cond. corrected	0.1	0.1	0.1	0.3	0.1	-0.4
Cocaine response after cond. not corrected	0.0	0.0	0.1	0.2	0.1	-0.2
Cocaine response before conditioning	0.5	0.6	0.8	0.8	0.9	-0.4
Saline control response	0.0	0.0	0.0	0.1	0.0	-0.2
Bone: connectivity density	0.0	0.0	0.0	-0.1	0.1	0.2
Bone: cortical apparent density	2.5	3.5	3.9	-1.8	-1.8	2.0
Bone: cortical area	1.9	2.9	3.0	1.7	1.7	-1.7
Bone: cortical porosity	1.5	1.6	1.8	-1.2	-1.2	1.3
Bone: cortical porosity	2.0	2.2	2.5	-1.4	-1.4	1.6
Bone: cortical thickness	0.8	1.4	1.5	1.2	1.1	-1.2
Bone: cortical thickness	0.5	0.6	0.6	-0.7	-0.8	0.7
Bone: cortical tissue density	2.9	3.9	4.4	-1.9	-1.9	2.1
Condit. Reinf. active minus inactive responses	0.2	0.3	0.3	-0.5	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.4	-0.3	0.3
Condit. Reinf. active responses	2.1	2.5	2.9	-1.5	-1.5	1.7
Condit. Reinf. inactive responses	1.9	2.3	2.8	-1.4	-1.5	1.7
Incentive salience index mean	0.1	0.2	0.2	-0.4	-0.3	0.4
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	0.1	0.0
Condit. Reinf. active minus inactive responses	3.0	3.9	4.4	1.9	1.9	-2.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	0.6	0.4	-0.7
Condit. Reinf. active responses	4.7	6.5	6.6	2.5	2.5	-2.6
Condit. Reinf. inactive responses	3.5	4.5	5.0	2.1	2.2	-2.1
Condit. Reinf. lever presses	9.8	13.6	13.7	3.7	3.7	-3.7
Condit. Reinf. lever reinforcers received	5.2	7.2	7.3	2.7	2.7	-2.7
Conditioned reinforcement - actives	0.4	0.6	0.7	-0.8	-0.8	0.7
Conditioned reinforcement - inactives	0.3	0.5	0.5	0.7	0.6	-0.7
Conditioned locomotion	2.8	3.7	3.9	-2.0	-1.8	2.0
Patch foraging indifference point 0 sec	0.1	0.2	0.2	0.4	0.4	-0.4
Patch foraging indifference point AUC	0.5	0.8	0.9	-0.9	-1.0	0.7
Delay disc. indifference point, 0s delay	1.2	1.3	1.7	1.0	1.1	-1.3
Delay disc. indifference point, 16s delay	3.0	3.3	3.7	1.8	1.8	-1.9
Delay disc. indifference point, 2s delay	1.4	1.6	2.1	1.1	1.2	-1.4
Delay disc. indifference point, 24s delay	2.4	2.7	2.8	1.7	1.7	-1.6
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	0.4	0.4	-0.6
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.1	0.2	0.0
Indifference point function ln k	0.4	0.7	0.7	0.8	0.9	-0.8
Indifference point function log k	0.4	0.7	0.7	0.8	0.9	-0.8
Patch foraging total patch changes 0 sec	0.1	0.3	0.3	0.6	0.5	-0.5
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.3	0.3	-0.4
Patch foraging total patch changes 18 sec	0.3	0.5	0.5	-0.7	-0.7	0.7
Patch foraging total patch changes 24 sec	0.4	0.7	0.9	0.8	0.7	-0.9
Patch foraging total patch changes 6 sec	0.0	0.0	0.0	-0.0	-0.1	-0.1
Patch foraging time to switch 0 sec	0.2	0.5	0.6	-0.8	-0.7	0.7
Patch foraging water rate 0 sec	0.6	1.3	1.4	-1.1	-1.2	1.2
Patch foraging water rate 12 sec	0.3	0.7	0.9	0.8	0.6	-1.0
Patch foraging water rate 18 sec	0.1	0.2	0.2	-0.4	-0.4	0.3
Patch foraging water rate 24 sec	0.0	0.0	0.0	0.2	0.1	-0.2
Patch foraging water rate 6 sec	0.3	0.4	0.4	0.6	0.6	-0.6
Seeking ratio, delayed vs. immediate footshock	1.6	1.9	2.1	1.4	1.3	-1.4
Distance traveled before self-admin	1.6	2.0	2.2	1.4	1.4	-1.5
Distance traveled after self-admin	2.3	2.8	3.2	1.8	1.8	-1.4
Extensor digitorum longus weight	0.2	0.9	0.9	-1.0	-1.0	0.9
Bone: elastic displacement	0.0	0.0	0.0	-0.0	-0.0	-0.2
Bone: elastic work	2.2	2.9	3.2	1.7	1.7	-1.8
Bone: endosteal estimation	1.5	3.4	3.7	1.9	1.9	-1.7
Bone: endosteal perimeter	1.7	3.5	3.6	1.8	1.9	-1.9
Epididymis fat weight	0.1	0.3	0.5	-0.3	-0.4	0.7
Delta time in closed arm before/after self-admin	0.4	0.4	0.5	0.6	0.7	-0.6
Delta time in open arm before/after self-admin	0.4	0.4	0.6	-0.6	-0.8	0.6
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	0.1	-0.1
Delay discount exponential model param	1.2	1.3	1.6	-1.1	-1.1	1.3
Extinction: sum of active levers before priming	2.5	2.8	3.5	1.7	1.9	-1.3
Active lever presses in extinction session 6	1.6	1.6	1.9	1.2	1.4	-1.2
Bone: final force	1.5	2.5	2.7	1.6	1.6	-1.4
Bone: final moment	2.2	3.5	3.8	2.0	1.9	-1.7
Food consumed during 24 hour testing period	0.5	0.7	0.8	0.9	0.9	-0.8
Glucose	0.2	0.4	0.5	-0.5	-0.6	0.7
Heart weight	0.3	0.4	0.7	0.6	0.5	-0.8
Delay discount hyperbolic model param	0.9	1.0	1.2	-0.9	-1.0	1.1
Intermittent access intake day 1-15 change	0.7	1.4	1.8	1.1	1.1	-1.3
Intermittent access intake escalation	0.3	0.7	0.9	0.7	0.8	-0.9
Intermittent access intake escalation 2	1.8	2.0	2.3	1.4	1.4	-1.5
Intermitt. access day 1 inactive lever presses	1.7	6.5	7.3	2.7	2.7	-2.2
Intermitt. access day 15 inactive lever presses	0.7	1.3	1.5	1.2	1.2	-1.1
Intermitt. access escalation Index	0.0	0.0	0.0	0.2	0.1	-0.1
Intermittent access day 1 total infusions	0.8	1.3	1.4	-1.1	-1.2	1.1
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.0	-0.0	-0.3
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.2	0.1	-0.5
Intermittent access total infusions	0.1	0.2	0.2	-0.4	-0.5	0.3
Intermittent access day 1 locomotion	0.2	0.2	0.3	-0.5	-0.5	0.5
Intermittent access day 15 total locomotion	0.0	0.0	0.1	-0.3	-0.1	0.2
Intermittent access total locomotion	0.7	0.9	1.0	-1.0	-0.9	0.9
Intermittent access standard deviation	2.6	5.4	5.7	2.3	2.3	-2.4
Left kidney weight	1.3	6.2	7.5	2.7	2.5	-2.2
Right kidney weight	2.0	9.2	10.6	3.3	3.1	-2.7
Cocaine induced anxiety	0.0	0.0	0.0	-0.1	-0.0	-0.1
Post-drug Anxiety	0.2	0.2	0.2	0.4	0.4	-0.5
Baseline Anxiety	0.1	0.2	0.3	0.5	0.4	-0.2
Tail length	5.7	22.2	23.0	4.8	4.7	-4.7
Length with tail	7.3	31.7	32.9	5.7	5.6	-5.6
Length without tail	2.3	7.5	7.8	2.8	2.7	-2.7
Times rat made contact with spout	1.3	1.5	1.7	-1.2	-1.2	1.3
Lifetime Intake	0.4	0.5	0.6	-0.7	-0.8	0.6
Liver weight, left	0.2	0.4	0.5	-0.5	-0.7	0.7
Liver weight, right	0.0	0.1	0.1	-0.2	-0.4	0.2
Locomotor activity	0.8	1.2	1.6	-1.0	-1.0	1.3
Locomotor testing distance	1.3	2.3	2.8	-1.5	-1.4	1.7
Locomotor testing rearing	2.1	4.2	4.5	-2.1	-2.1	2.0
Locomotion in novel chamber	0.0	0.0	0.0	-0.2	0.0	0.1
Locomotion in novel chamber post-restriction	0.6	1.0	1.2	0.8	1.0	-1.1
Fecal boli incidents, locomotor time 1	1.4	2.0	2.3	-1.4	-1.3	1.5
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	-0.1	-0.1	-0.1
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	-0.0	-0.1	0.1
Bouts of movement, locomotor time 1	2.6	3.0	4.2	1.5	1.6	-2.0
Total resting periods, locomotor time 1	2.7	3.0	4.2	1.5	1.6	-2.1
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.4	-0.4	0.2
Distance moved, locomotor task time 1	0.1	0.1	0.1	-0.2	-0.3	0.3
Vertical activity count, locomotor time 1	0.3	0.8	0.9	0.9	0.9	-0.8
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.3	-0.3	-0.5	0.6
Bouts of movement, locomotor time 2	0.2	0.3	0.7	0.3	0.3	-0.8
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.1	0.1	-0.6
Rest time, locomotor task time 2	0.0	0.0	0.0	0.0	-0.1	-0.0
Distance moved, locomotor task time 2	0.3	0.4	0.4	-0.6	-0.7	0.6
Vertical activity count, locomotor time 2	0.3	0.5	0.6	0.7	0.6	-0.7
Light reinforcement 1	0.1	0.3	0.4	-0.6	-0.7	0.3
Light reinforcement 2	3.1	4.8	5.8	-2.4	-2.2	1.9
Bone: marrow area	1.6	3.5	3.8	1.9	2.0	-1.7
Bone: maximum diameter	1.5	2.8	2.8	1.7	1.7	-1.7
Bone: maximum force	2.9	5.1	5.5	2.4	2.3	-2.1
Bone: maximum moment	3.7	6.4	6.9	2.6	2.6	-2.4
Mean time between licks in bursts	0.0	0.1	0.1	0.3	0.2	-0.3
Mean num. licks in bursts	0.9	1.4	1.6	1.2	1.3	-1.1
Cd content in liver	0.5	0.5	0.6	-0.7	-0.7	0.8
Co content in liver	0.8	0.9	1.0	-1.0	-0.9	0.9
Cu content in liver	1.1	1.3	1.4	1.1	1.1	-1.2
Fe content in liver	0.3	0.4	0.4	-0.6	-0.6	0.6
K content in liver	0.2	0.2	0.3	0.5	0.4	-0.5
Mg content in liver	0.1	0.1	0.2	-0.3	-0.4	0.2
Mn content in liver	0.3	0.3	0.5	-0.4	-0.5	0.7
Na content in liver	1.4	1.5	1.6	1.3	1.1	-1.3
Rb content in liver	0.0	0.0	0.0	-0.1	-0.1	0.0
Se content in liver	5.7	6.7	6.9	-2.5	-2.6	2.6
Sr content in liver	0.4	0.3	0.5	-0.5	-0.5	0.7
Zn content in liver	3.6	4.0	4.2	-2.0	-2.0	2.0
Bone: minimum diameter	5.0	9.1	9.4	3.1	3.0	-3.0
Time in familiar zone, hab. session 1	0.3	0.3	0.3	0.6	0.5	-0.5
Time in novel zone, hab. session 1	0.5	0.5	0.7	-0.8	-0.9	0.5
Total zone transitions, hab. session 1	0.1	0.1	0.1	0.4	0.3	-0.2
Total locomotion distance, hab. session 1	2.7	3.8	4.0	2.0	1.9	-1.9
Locomotion velocity, hab. session 1	1.4	1.9	2.1	1.4	1.4	-1.3
Time in familiar zone, hab. session 2	2.2	2.4	2.6	1.4	1.6	-1.6
Time in novel zone, hab. session 2	1.4	1.4	1.5	-1.1	-1.2	1.2
Total zone transitions, hab. session 2	1.8	2.3	2.6	-1.4	-1.6	1.5
Total locomotion distance, hab. session 2	0.0	0.0	0.0	0.2	0.1	-0.2
Locomotion velocity, hab. session 2	0.0	0.0	0.0	-0.0	-0.1	0.1
Novel to familiar place preference ratio	0.4	0.4	0.5	0.7	0.5	-0.7
Novelty place preference	0.2	0.3	0.3	0.6	0.4	-0.5
Time in novel zone, NPP test	0.1	0.1	0.1	0.3	0.2	-0.3
Total zone transitions, NPP test	0.1	0.2	0.3	-0.3	-0.3	0.5
Total locomotion distance, NPP test	2.8	3.9	4.1	2.0	2.0	-1.9
Locomotion velocity, NPP test	3.1	4.4	4.6	2.1	2.2	-2.0
Intraocular pressure	0.0	0.0	0.0	0.1	0.1	-0.0
Delta distance traveled before/after self-admin	0.2	0.3	0.3	0.5	0.6	-0.4
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	0.5	0.5	-0.2
Parametrial fat weight	0.3	0.8	0.8	-0.9	-0.9	0.8
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.0	0.1	-0.2
Pavlov. Cond. magazine entry latency	0.4	0.5	0.6	-0.7	-0.8	0.6
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.3	-0.4	0.3
Pavlov. Cond. index score	0.3	0.4	0.4	-0.6	-0.6	0.7
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.3	-0.4	0.4
Pavlov. Cond. lever contacts	0.1	0.2	0.2	0.5	0.4	-0.4
Pavlov. Cond. magazine entry number	0.3	0.3	0.4	0.6	0.7	-0.5
Pavlov. Cond. intertrial magazine entries	0.6	0.7	0.8	-0.8	-0.8	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.6	-0.7	-0.8	0.8
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.3	-0.4	0.4
Pavlov. Cond. lever latency	5.4	7.4	7.4	-2.7	-2.7	2.7
Pavlov. Cond. magazine entry latency	4.0	4.8	5.0	2.2	2.2	-2.1
Pavlov. Cond. change in total contacts	8.2	13.1	14.0	3.6	3.6	-3.7
Pavlov. Cond. index score	6.2	8.3	8.5	2.9	2.9	-2.9
Pavlov. Cond. latency score	5.6	7.4	7.6	2.7	2.8	-2.7
Pavlov. Cond. lever contacts	6.0	8.3	8.4	2.9	2.9	-2.9
Pavlov. Cond. magazine entry number	3.9	4.8	5.0	-2.2	-2.2	2.2
Pavlov. Cond. intertrial magazine entries	2.0	3.0	3.8	-1.6	-1.6	1.9
Pavlov. Cond. lever-magazine prob. diff.	6.0	7.9	8.0	2.8	2.8	-2.8
Pavlov. Cond. response bias	6.9	9.3	9.4	3.1	3.1	-3.0
Time in closed arm before self-admin	0.4	0.5	0.7	-0.7	-0.9	0.5
Time in closed arm after self-admin	1.1	1.2	1.6	0.9	1.0	-1.3
Time in open arm before self-admin	2.0	2.2	3.0	1.6	1.7	-1.1
Time in open arm after self-admin	0.1	0.1	0.2	0.5	0.3	0.0
Bone: periosteal estimation	2.5	5.3	5.5	2.3	2.3	-2.2
Bone: periosteal perimeter	2.5	4.2	4.6	2.0	2.0	-2.1
Bone: post-yield work	2.1	3.1	3.3	1.8	1.8	-1.7
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	0.1	0.1	0.0
Progressive ratio test 1 breakpoint	0.0	0.1	0.1	0.3	0.3	-0.1
Progressive ratio test 1 inactive lever presses	0.4	0.6	0.6	0.8	0.8	-0.7
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	-0.4	-0.3	0.4
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	-0.5	-0.4	0.5
Progressive ratio test 2 inactive lever presses	1.1	1.7	1.8	1.2	1.3	-1.3
Incentive Sensitization - Responses	0.3	0.4	0.4	-0.6	-0.6	0.6
Incentive Sensitization - Breakpoint	0.3	0.4	0.4	-0.7	-0.6	0.6
Sum of active levers in priming session hrs 5-6	0.2	0.1	0.3	-0.3	-0.2	0.5
Progressive ratio	0.0	0.0	0.0	-0.1	0.1	0.0
Food seeking constrained by brief footshock	3.4	4.1	4.6	2.1	2.1	-1.9
Seeking ratio, punishment vs. effort	0.7	1.1	1.2	1.0	0.9	-1.1
Retroperitoneal fat weight	0.8	3.2	3.3	-1.7	-1.8	1.8
Reaction time number correct	0.2	0.3	0.4	-0.5	-0.6	0.6
Reaction time mean minus median	0.0	0.1	0.1	0.3	0.3	-0.2
Reaction time mean minus median AUC	0.0	0.1	0.2	0.4	0.3	-0.2
Reaction time num false alarms	1.4	2.0	2.1	-1.4	-1.5	1.4
Reaction time num false alarms AUC	1.8	2.8	3.0	-1.6	-1.6	1.7
Reaction time trials correct on left	0.2	0.3	0.4	-0.5	-0.6	0.6
Reaction time trials on left	0.2	0.3	0.4	-0.5	-0.6	0.6
Reaction time mean	0.1	0.2	0.3	-0.3	-0.3	0.6
Reaction time mean AUC	0.2	0.4	0.7	-0.5	-0.5	0.8
Median of all reaction times	0.4	0.5	0.9	-0.6	-0.6	0.9
Reaction time omissions	0.4	0.5	0.6	-0.7	-0.7	0.7
Reaction time false alarm rate	0.7	1.0	1.1	-1.0	-1.0	1.0
Reaction time premature initiation rate	0.1	0.1	0.1	0.3	0.3	-0.4
Reaction time premature initiations	0.0	0.0	0.0	-0.1	-0.1	-0.0
Std. dev. reaction times	0.0	0.0	0.0	0.2	0.1	0.0
Reaction time trials completed	0.2	0.3	0.4	-0.5	-0.6	0.6
Reaction time trials AUC	0.3	0.6	0.7	-0.7	-0.8	0.8
Run reversals in cocaine runway, females	0.0	0.0	0.0	0.0	0.1	0.0
Run reversals in cocaine runway, males	1.2	1.2	1.6	-1.1	-1.0	1.2
Latency to leave start box in cocaine runway	0.0	0.0	0.0	-0.1	-0.1	0.1
Latency to leave start box in cocaine runway, F	0.3	0.4	0.4	-0.6	-0.6	0.6
Latency to leave start box in cocaine runway, M	0.2	0.2	0.2	0.4	0.3	-0.5
Std. dev. time between licks in bursts	0.8	1.1	1.6	1.0	1.0	-1.3
Total sessions with >9 infusions	2.2	2.6	3.2	-1.5	-1.5	1.8
Short access day 1 total inactive lever presses	1.0	1.3	1.5	1.1	1.1	-1.2
Short access day 10 total inactive lever presses	2.8	6.9	7.5	2.5	2.6	-2.7
Short access day 1 total infusions	0.0	0.0	0.1	0.2	0.1	-0.3
Short access day 10 total infusions	0.6	0.7	1.0	-0.8	-0.8	1.0
Short access total infusions	0.8	1.1	1.1	-1.0	-1.0	1.1
Short access day 1 locomotion	2.7	3.4	4.0	-1.8	-1.8	2.0
Short access day 10 total locomotion	0.3	0.6	0.9	0.8	0.9	-0.5
Short access total locomotion	1.1	1.4	1.7	-1.1	-1.1	1.3
One hour access (0.3 mA shock)	0.9	1.1	1.3	1.0	1.0	-1.1
Compulsive drug intake	0.9	1.1	1.6	1.1	0.7	-1.2
One hour access (shock baseline)	0.0	0.0	0.0	0.0	0.2	-0.1
Social response proportion	4.0	4.6	5.1	2.0	2.1	-2.3
Social responses	0.6	0.8	1.0	0.8	1.0	-0.9
Social time	2.0	2.8	3.1	1.7	1.8	-1.5
Soleus weight	0.2	0.5	0.5	-0.7	-0.6	0.7
Bone: stiffness	1.6	2.6	2.8	1.7	1.7	-1.4
Tibialis anterior weight	0.1	0.2	0.3	-0.4	-0.5	0.5
Time to tail flick, vehicle, before self-admin	0.8	0.9	1.3	-0.8	-0.8	1.1
Time to tail flick, vehicle, after self-admin	1.7	2.2	2.4	1.4	1.5	-1.5
Time to tail flick, test, before self-admin	0.5	0.5	0.5	-0.7	-0.7	0.7
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.3	-0.2	0.0
Delta time to tail flick, vehicle, before/after SA	1.4	1.4	1.4	1.1	1.2	-1.2
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	-0.0	0.0	-0.2
Tibia length	1.9	5.1	5.6	2.3	2.4	-2.1
Ambulatory time before self-admin	1.5	2.3	2.5	1.5	1.5	-1.6
Ambulatory time after self-admin	3.8	4.5	5.2	2.2	2.3	-1.8
Bone: tissue strength	3.8	3.8	4.2	2.1	1.9	-1.9
Total heroin consumption	0.5	0.6	0.8	0.9	0.9	-0.6
Bone: trabecular number	0.4	0.6	0.9	0.8	0.9	-0.6
Bone: trabecular spacing	1.0	1.3	1.5	1.2	1.0	-1.2
Bone: trabecular thickness	0.3	0.4	0.4	-0.7	-0.7	0.6
Bone: trabecular tissue density	2.0	2.9	3.1	-1.8	-1.7	1.7
Water consumed over 24 hours	0.2	0.3	0.3	0.5	0.6	-0.4
Number of responses in last shaping day	0.5	0.6	0.9	0.6	0.6	-1.0