LOC134484003

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr1_246752737_246761790	0.28	0.1	8.8e-15	0.1	0.1	0.1	0.1	3.6e-11	4.5e-11	2.6e-11	3.5e-11
2	Liver	intron excision ratio	chr1_246752737_246753675	0.31	0.1	0.0e+00	0.12	0.12	0.13	0.12	9.9e-14	1.5e-13	7.7e-14	9.5e-14
3	Liver	mRNA stability	LOC134484003	0.15	0.1	4.6e-06	0.04	0.03	0.03	0.03	4.6e-05	2.9e-04	1.2e-04	1.1e-04
4	Liver	intron excision ratio	chr1_247018300_247053570	0.41	0.04	0.0e+00	0.18	0.34	0.34	0.34	1.2e-19	6.4e-39	2.2e-38	2.1e-38
5	Liver	intron excision ratio	chr1_247037788_247053570	0.43	0.04	0.0e+00	0.18	0.34	0.34	0.34	1.1e-19	8.3e-39	2.6e-38	2.9e-38

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.3	0.6	1.4	0.7	-0.8	-1.2	-0.3	0.3
Area under the delay curve	2.7	3.2	4.0	-2.0	1.8	1.4	-1.8	1.8
BMI with tail	0.1	0.5	1.1	0.6	-0.9	-1.1	-0.2	0.2
BMI without tail	0.1	0.2	0.4	0.3	-0.6	-0.3	0.5	-0.5
Body weight	0.4	2.0	2.1	1.4	-1.3	-1.4	1.4	-1.4
Weight adjusted by age	0.0	0.1	0.2	0.0	-0.2	-0.5	-0.1	0.1
Bone surface	0.7	1.3	2.8	1.3	-1.4	-1.7	0.2	-0.2
Bone volume	1.1	2.0	3.6	1.6	-1.7	-1.9	0.8	-0.8
Breakpoint value in progressive ratio session	0.6	0.7	0.9	-0.8	0.9	1.0	-0.8	0.8
Number of licking bursts	2.4	4.0	4.8	-2.2	2.0	1.9	-1.9	1.9
Context. condit. distance diff. score	0.2	0.2	0.6	0.5	-0.5	-0.8	-0.0	0.0
Locomotion velocity, session 1	6.1	6.6	8.1	-2.8	2.7	2.7	-2.3	2.3
Locomotion distance, session 1	1.8	2.3	3.3	-1.6	1.6	1.8	-1.2	1.2
Locomotion velocity, session 2	3.5	4.0	6.0	-1.8	1.7	1.6	-2.4	2.4
Locomotion distance, session 2	1.1	1.5	2.0	-1.1	1.1	1.0	-1.4	1.4
Locomotion velocity, session 3	0.0	0.0	0.1	0.3	-0.2	0.1	0.2	-0.2
Locomotion distance, session 3	1.1	1.2	1.9	1.1	-0.8	-0.6	1.4	-1.4
Stereotopy head waving bouts, day 3	0.2	0.2	0.2	-0.5	0.5	0.4	-0.4	0.4
Stereotopy head waving duration, day 3	0.8	0.9	1.1	-1.0	0.9	0.8	-1.1	1.0
Locomotion velocity, session 7	1.2	1.3	1.7	1.3	-1.2	-1.2	1.0	-1.0
Locomotion distance, session 7	2.1	2.6	3.3	1.8	-1.7	-1.6	1.5	-1.4
Stereotopy head waving bouts, day 7	2.5	2.8	3.4	-1.8	1.8	1.8	-1.5	1.5
Stereotopy head waving duration, day 7	1.3	1.5	1.9	-1.3	1.4	1.3	-1.1	1.1
Locomotion velocity, session 8	0.2	0.2	0.5	-0.2	0.3	0.2	-0.7	0.7
Locomotion distance, session 8	0.5	0.7	1.7	-0.5	0.4	0.1	-1.3	1.3
Degree of sensitization distance	0.5	0.5	1.0	-0.5	0.3	0.2	-1.0	1.0
Degree of sensitization stereotypy	2.6	2.8	3.6	-1.8	1.9	1.8	-1.4	1.4
Conditioned locomotion	1.6	1.8	2.0	1.4	-1.3	-1.4	1.3	-1.3
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.4	0.3	0.3	-0.4	0.4
Cocaine response after cond. not corrected	0.2	0.2	0.3	-0.5	0.5	0.5	-0.5	0.5
Cocaine response before conditioning	0.6	0.7	1.0	-0.7	0.9	1.0	-0.7	0.7
Saline control response	1.2	1.6	2.6	-1.4	1.6	1.6	-0.7	0.7
Bone: connectivity density	0.8	1.2	3.0	1.1	-1.4	-1.7	-0.1	0.0
Bone: cortical apparent density	1.8	2.4	3.1	-1.8	1.6	1.4	-1.5	1.5
Bone: cortical area	2.0	3.1	3.5	1.9	-1.6	-1.5	1.9	-1.9
Bone: cortical porosity	1.5	1.6	3.2	-1.0	0.7	0.5	-1.8	1.8
Bone: cortical porosity	0.7	0.7	1.6	-0.5	0.4	0.2	-1.3	1.3
Bone: cortical thickness	0.2	0.4	0.6	-0.1	0.5	0.7	0.8	-0.7
Bone: cortical thickness	1.9	2.3	3.6	-1.7	1.8	1.9	-0.9	0.9
Bone: cortical tissue density	2.0	2.8	3.5	-1.9	1.7	1.4	-1.7	1.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.5	0.5	0.6	-0.4	0.4
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.2	0.2	0.1	-0.1	0.1
Condit. Reinf. active responses	0.1	0.1	0.2	-0.3	0.3	0.4	-0.0	0.0
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.4	0.4	0.6	-0.1	0.1
Incentive salience index mean	0.1	0.1	0.3	-0.4	0.5	0.5	-0.1	0.1
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.5	0.6	0.6	0.1	-0.1
Condit. Reinf. active minus inactive responses	1.5	1.9	2.9	1.6	-1.7	-1.7	0.9	-0.9
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.4	0.9	-1.2	-1.1	0.4	-0.4
Condit. Reinf. active responses	1.9	2.6	3.0	1.7	-1.6	-1.5	1.6	-1.6
Condit. Reinf. inactive responses	0.8	1.0	2.1	0.8	-0.3	-0.2	1.4	-1.4
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.0	0.3	0.2	0.2	-0.2
Condit. Reinf. lever reinforcers received	1.0	1.3	1.6	1.2	-1.1	-1.0	1.2	-1.2
Conditioned reinforcement - actives	0.5	0.8	1.1	-0.7	0.9	0.6	-1.0	1.1
Conditioned reinforcement - inactives	1.4	2.1	3.2	-1.2	1.3	1.1	-1.8	1.8
Conditioned locomotion	0.2	0.3	0.5	-0.6	0.7	0.6	-0.4	0.4
Patch foraging indifference point 0 sec	0.2	0.3	0.8	0.2	0.1	0.1	0.9	-0.9
Patch foraging indifference point AUC	3.4	4.8	7.5	-2.4	2.5	2.7	-1.5	1.5
Delay disc. indifference point, 0s delay	0.4	0.4	0.8	-0.3	-0.0	-0.7	-0.9	0.9
Delay disc. indifference point, 16s delay	1.6	1.8	2.0	-1.4	1.4	1.3	-1.3	1.3
Delay disc. indifference point, 2s delay	0.7	0.8	1.2	-1.0	0.7	0.2	-1.1	1.1
Delay disc. indifference point, 24s delay	3.1	3.5	4.4	-2.0	2.1	1.9	-1.6	1.6
Delay disc. indifference point, 4s delay	1.7	1.8	2.3	-1.5	1.4	0.8	-1.5	1.5
Delay disc. indifference point, 8s delay	4.5	5.3	7.4	-2.7	2.6	2.1	-2.0	2.0
Indifference point function ln k	2.6	4.5	6.2	2.3	-2.5	-2.5	1.6	-1.6
Indifference point function log k	2.6	4.5	6.2	2.3	-2.5	-2.5	1.6	-1.6
Patch foraging total patch changes 0 sec	0.3	0.5	1.2	0.4	-0.1	0.0	1.1	-1.1
Patch foraging total patch changes 12 sec	2.7	3.5	5.4	-2.1	2.3	2.3	-1.1	1.1
Patch foraging total patch changes 18 sec	1.1	1.7	2.9	-1.4	1.4	1.7	-0.9	0.9
Patch foraging total patch changes 24 sec	0.2	0.3	0.6	-0.4	0.7	0.8	0.2	-0.2
Patch foraging total patch changes 6 sec	2.2	3.3	5.8	-2.0	2.4	2.4	-0.8	0.9
Patch foraging time to switch 0 sec	0.9	1.9	2.1	-1.5	1.3	1.2	-1.4	1.4
Patch foraging water rate 0 sec	0.8	1.7	2.1	1.4	-1.4	-1.4	1.1	-1.1
Patch foraging water rate 12 sec	0.5	0.9	1.1	1.0	-1.0	-0.8	1.0	-1.0
Patch foraging water rate 18 sec	0.3	0.5	0.8	0.9	-0.8	-0.7	0.6	-0.5
Patch foraging water rate 24 sec	0.3	0.5	0.7	0.8	-0.8	-0.8	0.5	-0.5
Patch foraging water rate 6 sec	0.1	0.1	0.2	0.3	-0.4	-0.1	0.3	-0.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.3	0.4	-0.1	-0.5	0.6	-0.6
Distance traveled before self-admin	0.1	0.2	0.4	-0.2	0.1	0.2	-0.6	0.6
Distance traveled after self-admin	0.2	0.2	0.5	0.5	-0.5	-0.7	-0.3	0.3
Extensor digitorum longus weight	0.1	0.3	0.6	0.7	-0.7	-0.8	0.3	-0.3
Bone: elastic displacement	0.0	0.0	0.1	-0.3	-0.1	-0.2	-0.2	0.1
Bone: elastic work	0.0	0.1	0.1	-0.1	-0.2	-0.4	-0.3	0.2
Bone: endosteal estimation	1.8	3.9	6.7	2.3	-2.4	-2.6	0.9	-0.9
Bone: endosteal perimeter	1.8	3.9	7.1	2.3	-2.4	-2.7	0.8	-0.8
Epididymis fat weight	1.2	4.2	5.2	2.0	-2.2	-2.3	1.8	-1.8
Delta time in closed arm before/after self-admin	0.3	0.3	0.7	0.4	-0.2	0.0	0.8	-0.8
Delta time in open arm before/after self-admin	0.5	0.5	1.2	0.0	-0.2	-0.4	-1.1	1.1
Diff in mean of infusions in LGA sessions	0.1	0.2	0.4	0.6	-0.6	-0.2	-0.1	0.1
Delay discount exponential model param	2.9	3.2	3.9	2.0	-1.9	-1.4	1.8	-1.8
Extinction: sum of active levers before priming	0.1	0.1	0.1	0.4	-0.2	0.2	0.3	-0.3
Active lever presses in extinction session 6	1.6	1.6	3.8	-0.5	0.2	-0.2	-1.9	1.9
Bone: final force	0.2	0.4	0.6	0.8	-0.5	-0.4	0.6	-0.6
Bone: final moment	0.5	0.8	1.0	1.0	-0.7	-0.7	0.9	-0.9
Food consumed during 24 hour testing period	0.3	0.4	0.7	-0.6	0.8	0.9	-0.3	0.3
Glucose	0.6	0.9	1.1	1.0	-0.9	-0.5	1.0	-1.0
Heart weight	2.3	3.6	5.8	1.7	-1.5	-1.1	2.4	-2.4
Delay discount hyperbolic model param	2.2	2.4	3.2	1.8	-1.6	-1.1	1.6	-1.6
Intermittent access intake day 1-15 change	0.3	0.7	1.2	1.0	-1.0	-1.1	0.2	-0.1
Intermittent access intake escalation	0.5	1.1	1.8	1.3	-1.3	-1.4	0.3	-0.3
Intermittent access intake escalation 2	0.6	0.7	1.5	0.9	-1.0	-1.2	-0.3	0.3
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.3	-0.2	0.1	-0.3	-0.5	0.5
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.6	0.6	-0.5	-0.8	0.4	-0.4
Intermitt. access escalation Index	0.9	1.3	1.5	1.1	-1.2	-1.0	1.2	-1.2
Intermittent access day 1 total infusions	0.1	0.2	0.4	-0.4	0.4	0.2	-0.6	0.6
Intermittent access day 15 total infusions	1.0	1.4	2.3	1.5	-1.4	-1.3	0.8	-0.8
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.5	0.7	-0.6	-0.7	-0.0	0.0
Intermittent access total infusions	0.1	0.1	0.2	0.4	-0.4	-0.5	0.1	-0.0
Intermittent access day 1 locomotion	0.4	0.5	0.9	0.8	-0.8	-1.0	0.4	-0.4
Intermittent access day 15 total locomotion	0.7	1.3	1.6	-1.1	1.1	0.8	-1.3	1.3
Intermittent access total locomotion	0.8	0.9	1.7	-0.8	0.7	0.3	-1.3	1.3
Intermittent access standard deviation	0.2	0.4	0.8	0.7	-0.6	-0.9	-0.4	0.5
Left kidney weight	0.1	0.3	0.5	0.1	0.1	0.7	0.7	-0.7
Right kidney weight	0.1	0.6	0.9	-0.1	0.3	0.9	1.0	-0.9
Cocaine induced anxiety	0.3	0.4	0.7	0.7	-0.8	-0.8	0.0	-0.1
Post-drug Anxiety	1.6	1.7	2.0	1.2	-1.3	-1.1	1.4	-1.4
Baseline Anxiety	1.4	1.6	3.2	0.9	-0.8	-0.4	1.8	-1.8
Tail length	0.3	1.4	2.6	1.0	-0.8	-0.4	1.6	-1.6
Length with tail	0.2	0.8	1.8	0.7	-0.2	-0.1	1.4	-1.3
Length without tail	0.0	0.0	0.1	0.3	0.1	-0.2	0.0	-0.0
Times rat made contact with spout	0.3	0.4	0.5	-0.6	0.5	0.5	-0.7	0.7
Lifetime Intake	0.0	0.1	0.1	0.3	-0.3	-0.4	0.0	-0.0
Liver weight, left	0.1	0.1	0.2	0.2	-0.1	-0.3	0.4	-0.4
Liver weight, right	0.4	0.8	1.1	1.0	-0.9	-1.1	0.7	-0.7
Locomotor activity	0.0	0.0	0.1	0.0	0.1	0.3	0.1	-0.1
Locomotor testing distance	0.0	0.1	0.2	-0.2	0.3	0.4	-0.1	0.1
Locomotor testing rearing	0.0	0.1	0.2	0.3	-0.4	-0.4	-0.2	0.1
Locomotion in novel chamber	1.2	1.5	3.0	1.4	-1.7	-1.5	0.3	-0.3
Locomotion in novel chamber post-restriction	0.0	0.1	0.2	-0.2	0.3	0.4	-0.1	0.2
Fecal boli incidents, locomotor time 1	0.3	0.5	0.9	-0.5	0.5	-0.0	-1.0	1.0
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.3	-0.2	-0.1	0.6	-0.6
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.1	0.2	0.5	0.0	0.0
Bouts of movement, locomotor time 1	1.5	1.7	2.2	-1.5	1.4	1.4	-1.1	1.1
Total resting periods, locomotor time 1	2.5	2.8	3.5	-1.8	1.8	1.9	-1.4	1.4
Rest time, locomotor task time 1	1.4	1.8	2.2	-1.4	1.2	1.0	-1.5	1.5
Distance moved, locomotor task time 1	2.5	3.8	5.5	1.9	-1.7	-1.2	2.3	-2.3
Vertical activity count, locomotor time 1	0.6	1.5	2.3	1.3	-1.0	-0.6	1.5	-1.5
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.4	-0.4	0.5	0.6	-0.4	0.5
Bouts of movement, locomotor time 2	4.1	6.5	7.6	-2.8	2.7	2.2	-2.5	2.5
Total resting periods, locomotor time 2	4.1	7.3	8.3	-2.9	2.8	2.4	-2.7	2.7
Rest time, locomotor task time 2	2.0	2.6	2.7	-1.6	1.6	1.6	-1.6	1.6
Distance moved, locomotor task time 2	3.4	4.0	5.1	2.0	-1.9	-1.5	2.3	-2.2
Vertical activity count, locomotor time 2	0.4	0.5	0.7	0.8	-0.7	-0.4	0.8	-0.8
Light reinforcement 1	0.1	0.2	0.4	-0.6	0.5	0.5	-0.1	0.1
Light reinforcement 2	2.3	3.6	5.5	-2.3	2.1	1.6	-1.6	1.6
Bone: marrow area	1.7	3.8	6.6	2.2	-2.4	-2.6	0.9	-0.9
Bone: maximum diameter	3.0	5.7	8.3	2.8	-2.8	-2.9	1.6	-1.5
Bone: maximum force	0.1	0.2	0.4	0.4	-0.4	-0.6	-0.1	0.1
Bone: maximum moment	0.2	0.4	0.7	0.7	-0.7	-0.9	0.3	-0.2
Mean time between licks in bursts	0.5	1.2	2.1	1.0	-0.8	-0.6	1.4	-1.4
Mean num. licks in bursts	1.9	3.0	4.0	2.0	-1.9	-1.8	1.5	-1.5
Cd content in liver	0.8	0.9	1.5	-1.1	1.1	1.2	-0.4	0.3
Co content in liver	2.0	2.3	4.8	1.0	-0.9	-0.4	2.2	-2.2
Cu content in liver	5.9	7.0	8.4	-2.9	2.9	2.9	-2.3	2.3
Fe content in liver	2.0	2.4	3.2	-1.7	1.7	1.8	-1.2	1.2
K content in liver	3.0	2.9	4.3	-1.5	1.4	1.3	-2.1	2.1
Mg content in liver	2.5	2.5	3.5	-1.5	1.3	1.3	-1.9	1.9
Mn content in liver	9.4	10.5	11.9	-3.3	3.0	2.9	-3.5	3.4
Na content in liver	2.6	2.7	3.1	-1.7	1.6	1.7	-1.6	1.6
Rb content in liver	0.1	0.1	0.1	-0.3	0.2	0.2	-0.3	0.3
Se content in liver	18.1	21.4	27.7	-5.1	5.1	5.3	-3.7	3.7
Sr content in liver	0.6	0.5	0.7	-0.8	0.8	0.8	-0.6	0.6
Zn content in liver	2.7	3.0	3.6	-1.9	1.8	1.9	-1.5	1.5
Bone: minimum diameter	6.4	11.6	14.6	3.8	-3.8	-3.8	2.7	-2.7
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.4	-0.5	-0.5	0.4	-0.4
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.4	0.5	0.5	-0.3	0.3
Total zone transitions, hab. session 1	0.2	0.3	0.4	-0.5	0.5	0.5	-0.6	0.6
Total locomotion distance, hab. session 1	1.7	2.4	3.4	-1.6	1.7	1.8	-1.2	1.2
Locomotion velocity, hab. session 1	2.2	3.1	5.1	-1.9	2.0	2.3	-1.2	1.2
Time in familiar zone, hab. session 2	0.6	0.6	1.2	0.5	-0.4	-0.5	1.1	-1.1
Time in novel zone, hab. session 2	0.2	0.2	0.3	-0.4	0.5	0.6	-0.5	0.5
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.4	0.6	0.4	-0.1	0.1
Total locomotion distance, hab. session 2	0.4	0.5	1.0	-0.8	0.9	1.0	-0.1	0.1
Locomotion velocity, hab. session 2	0.6	0.8	1.4	-1.0	1.1	1.2	-0.5	0.5
Novel to familiar place preference ratio	2.8	3.1	6.6	-1.1	0.8	0.4	-2.6	2.6
Novelty place preference	2.6	2.8	6.3	-1.0	0.7	0.3	-2.5	2.5
Time in novel zone, NPP test	2.1	2.3	5.2	-0.9	0.5	0.2	-2.3	2.3
Total zone transitions, NPP test	0.1	0.1	0.2	-0.2	0.5	0.5	0.3	-0.3
Total locomotion distance, NPP test	1.6	2.1	3.9	-1.6	1.8	2.0	-0.7	0.7
Locomotion velocity, NPP test	1.4	1.9	3.3	-1.5	1.7	1.8	-0.8	0.8
Intraocular pressure	0.1	0.1	0.3	-0.5	0.4	0.2	-0.3	0.3
Delta distance traveled before/after self-admin	1.2	1.2	2.1	1.2	-1.3	-1.4	0.6	-0.7
Delta ambulatory time before/after self-admin	1.7	2.1	3.1	1.6	-1.7	-1.7	1.0	-1.0
Parametrial fat weight	0.2	0.5	1.2	0.2	0.1	0.4	1.1	-1.1
Pavlov. Cond. lever latency	0.2	0.3	0.4	0.4	-0.5	-0.5	0.6	-0.6
Pavlov. Cond. magazine entry latency	0.2	0.3	0.9	-0.3	0.6	0.9	0.1	-0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.0	0.2	0.3	0.2	-0.1
Pavlov. Cond. index score	0.5	0.6	1.2	-0.7	0.9	1.1	-0.5	0.5
Pavlov. Cond. latency score	0.3	0.3	0.8	-0.5	0.7	0.9	-0.3	0.3
Pavlov. Cond. lever contacts	0.3	0.3	0.5	-0.5	0.7	0.7	-0.4	0.5
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.1	-0.1	-0.3	-0.3	0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.6	-0.7	0.7	0.5	-0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.1	-0.7	0.9	1.0	-0.4	0.5
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.2	0.4	0.5	-0.1	0.1
Pavlov. Cond. lever latency	0.3	0.3	0.7	0.6	-0.9	-0.8	-0.0	0.0
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	-0.5	0.7	0.7	-0.0	0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.0	0.2	0.1	0.5	-0.5
Pavlov. Cond. index score	0.3	0.4	0.8	-0.6	0.9	0.9	-0.0	0.0
Pavlov. Cond. latency score	0.3	0.4	0.9	-0.7	0.9	0.9	-0.2	0.2
Pavlov. Cond. lever contacts	0.2	0.3	0.6	-0.5	0.8	0.7	0.3	-0.2
Pavlov. Cond. magazine entry number	0.7	0.9	1.9	1.0	-1.3	-1.4	0.1	-0.1
Pavlov. Cond. intertrial magazine entries	0.2	0.4	0.7	0.6	-0.8	-0.9	0.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	-0.7	0.9	0.9	-0.1	0.1
Pavlov. Cond. response bias	0.2	0.3	0.7	-0.5	0.8	0.8	0.2	-0.2
Time in closed arm before self-admin	0.3	0.4	0.8	-0.6	0.4	0.2	-0.9	0.9
Time in closed arm after self-admin	0.0	0.0	0.1	-0.1	0.0	-0.1	0.3	-0.4
Time in open arm before self-admin	0.2	0.2	0.4	0.2	-0.4	-0.2	0.6	-0.7
Time in open arm after self-admin	0.3	0.3	0.7	-0.2	0.1	0.3	-0.8	0.8
Bone: periosteal estimation	1.7	3.6	5.4	2.2	-2.2	-2.3	1.2	-1.2
Bone: periosteal perimeter	2.2	3.8	5.5	2.2	-2.2	-2.3	1.4	-1.4
Bone: post-yield work	0.2	0.3	0.6	0.6	-0.7	-0.8	-0.0	0.0
Progressive ratio test 1 active lever presses	0.2	0.3	0.5	-0.4	0.4	0.1	-0.7	0.7
Progressive ratio test 1 breakpoint	0.2	0.3	0.5	-0.5	0.5	0.2	-0.7	0.7
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	-0.1	0.0	-0.5	-0.5	0.5
Progressive ratio test 2 active lever presses	0.8	0.9	1.8	-0.7	0.7	0.4	-1.3	1.3
Progressive ratio test 2 breakpoint	0.8	0.9	1.7	-0.7	0.7	0.5	-1.3	1.3
Progressive ratio test 2 inactive lever presses	0.7	1.1	2.0	-0.9	0.7	0.3	-1.4	1.4
Incentive Sensitization - Responses	0.7	0.9	1.9	-0.6	0.6	0.4	-1.4	1.4
Incentive Sensitization - Breakpoint	0.7	0.9	1.7	-0.6	0.7	0.5	-1.3	1.3
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.3	0.3	0.1	-0.1	0.1
Progressive ratio	0.5	0.8	1.2	0.6	-0.5	-1.0	1.1	-1.1
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.3	0.5	0.1	-0.3	0.3
Seeking ratio, punishment vs. effort	0.7	1.1	1.6	-0.9	1.0	1.3	-1.0	1.0
Retroperitoneal fat weight	0.3	1.1	2.2	0.7	-0.7	-0.4	1.5	-1.5
Reaction time number correct	0.4	0.8	1.8	0.9	-1.2	-1.4	-0.0	0.0
Reaction time mean minus median	0.7	1.8	2.8	1.3	-1.1	-0.7	1.7	-1.6
Reaction time mean minus median AUC	0.6	1.4	2.2	1.1	-0.9	-0.7	1.5	-1.5
Reaction time num false alarms	0.2	0.3	0.5	0.6	-0.4	-0.5	0.7	-0.7
Reaction time num false alarms AUC	0.4	0.6	0.8	0.8	-0.5	-0.6	0.9	-0.9
Reaction time trials correct on left	0.4	0.8	1.8	0.9	-1.2	-1.4	-0.0	0.0
Reaction time trials on left	0.5	0.9	1.8	1.0	-1.2	-1.4	0.1	-0.1
Reaction time mean	0.3	0.5	1.0	0.2	0.1	0.4	1.0	-1.0
Reaction time mean AUC	0.2	0.4	0.7	0.0	0.3	0.6	0.8	-0.8
Median of all reaction times	0.2	0.3	0.5	-0.2	0.5	0.7	0.5	-0.5
Reaction time omissions	1.1	1.6	2.4	1.3	-1.1	-0.6	1.6	-1.6
Reaction time false alarm rate	0.2	0.3	0.6	0.2	0.1	0.1	0.8	-0.8
Reaction time premature initiation rate	0.3	0.4	0.9	0.5	-0.2	-0.1	1.0	-0.9
Reaction time premature initiations	0.5	0.9	1.1	1.0	-0.8	-0.7	1.1	-1.0
Std. dev. reaction times	1.4	2.7	4.8	1.5	-1.1	-0.7	2.2	-2.2
Reaction time trials completed	0.5	0.9	1.8	1.0	-1.2	-1.4	0.1	-0.1
Reaction time trials AUC	0.4	0.7	1.6	0.9	-1.1	-1.3	-0.0	0.0
Run reversals in cocaine runway, females	1.5	1.5	1.8	-1.3	1.1	1.1	-1.4	1.3
Run reversals in cocaine runway, males	1.2	1.2	2.5	-1.2	1.4	1.6	-0.3	0.3
Latency to leave start box in cocaine runway	3.7	4.2	5.2	2.0	-2.2	-2.3	1.9	-1.9
Latency to leave start box in cocaine runway, F	3.6	4.1	6.6	2.0	-2.3	-2.6	1.5	-1.5
Latency to leave start box in cocaine runway, M	0.8	0.8	1.0	0.8	-0.8	-0.8	1.0	-1.0
Std. dev. time between licks in bursts	0.2	0.3	0.4	-0.7	0.7	0.6	0.1	-0.1
Total sessions with >9 infusions	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.1	0.1
Short access day 1 total inactive lever presses	0.3	0.4	1.1	0.2	-0.6	-1.0	-0.6	0.6
Short access day 10 total inactive lever presses	0.0	0.0	0.2	-0.2	0.4	-0.0	-0.1	0.1
Short access day 1 total infusions	0.8	1.0	1.4	-1.2	1.1	0.9	-0.9	0.9
Short access day 10 total infusions	0.2	0.3	0.6	-0.7	0.8	0.4	-0.2	0.2
Short access total infusions	0.2	0.2	0.3	-0.5	0.4	0.0	-0.5	0.5
Short access day 1 locomotion	0.2	0.2	0.3	-0.1	-0.3	-0.6	-0.5	0.5
Short access day 10 total locomotion	0.6	1.0	1.5	-1.0	1.0	0.5	-1.2	1.2
Short access total locomotion	0.2	0.3	0.5	-0.5	0.4	-0.3	-0.7	0.7
One hour access (0.3 mA shock)	0.4	0.5	1.0	0.1	-0.1	-0.6	-1.0	1.0
Compulsive drug intake	1.4	1.7	2.1	1.4	-1.4	-1.5	1.1	-1.1
One hour access (shock baseline)	0.1	0.1	0.3	-0.1	0.2	0.0	-0.6	0.6
Social response proportion	0.4	0.5	0.9	0.6	-0.9	-0.9	-0.5	0.5
Social responses	0.6	0.7	1.2	1.0	-1.0	-1.1	0.4	-0.4
Social time	0.0	0.0	0.0	0.2	-0.0	-0.0	-0.1	0.2
Soleus weight	0.4	1.2	2.2	1.3	-1.4	-1.5	0.5	-0.5
Bone: stiffness	0.2	0.4	0.7	0.8	-0.6	-0.8	0.4	-0.3
Tibialis anterior weight	0.1	0.4	0.7	0.8	-0.8	-0.8	0.0	-0.0
Time to tail flick, vehicle, before self-admin	1.1	1.2	1.6	-1.2	1.0	0.6	-1.2	1.2
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	0.4	-0.4	-0.6	-0.0	0.0
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.3	-0.4	-0.5	-0.2	0.2
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.5	0.3	0.0	-0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.6	-0.5	-0.2	0.1	-0.1
Delta time to tail flick, test, before/after SA	0.5	0.5	0.8	-0.9	0.8	0.6	-0.5	0.5
Tibia length	0.1	0.3	0.6	0.4	-0.3	-0.3	0.8	-0.8
Ambulatory time before self-admin	0.1	0.2	0.3	-0.2	0.2	0.0	-0.6	0.6
Ambulatory time after self-admin	0.4	0.4	0.8	0.5	-0.7	-0.9	-0.6	0.6
Bone: tissue strength	0.3	0.3	0.5	0.6	-0.6	-0.7	0.5	-0.5
Total heroin consumption	0.3	0.3	0.6	-0.4	0.5	0.8	-0.5	0.5
Bone: trabecular number	0.2	0.3	0.8	0.4	-0.5	-0.9	-0.3	0.3
Bone: trabecular spacing	0.4	0.5	1.1	0.3	-0.0	0.1	1.1	-1.1
Bone: trabecular thickness	1.1	1.3	1.9	1.4	-1.4	-1.3	0.8	-0.8
Bone: trabecular tissue density	0.4	0.7	1.1	0.9	-1.0	-1.0	0.4	-0.4
Water consumed over 24 hours	0.8	1.1	1.8	-0.9	0.8	0.7	-1.3	1.4
Number of responses in last shaping day	0.1	0.1	0.2	0.1	-0.2	-0.4	0.4	-0.4