Hub : Genes

LOC134483989

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA intron excision ratio chr1_244535817_244536599 0.05 0.04 2.9e-03 0.04 0.03 0.03 0.04 5.8e-04 2.3e-03 1.2e-03 5.3e-04
2 NAcc gene expression LOC134483989 0.07 0.05 1.0e-05 0.04 0.03 0.03 0.04 7.5e-07 7.4e-06 1.6e-05 2.5e-06
3 Adipose gene expression LOC134483989 0.04 0.03 4.7e-04 0.02 0.02 0.01 0.01 2.5e-03 6.5e-03 5.4e-02 4.5e-02
4 Liver gene expression LOC134483989 0.05 0.03 1.8e-03 0 0 -0 0 8.2e-02 1.2e-01 5.8e-01 1.0e-01
5 pVTA gene expression LOC134483989 0.16 0.09 1.5e-05 0.06 0.06 0.04 0.04 5.8e-06 2.5e-05 2.2e-04 1.7e-04
6 LHb intron excision ratio chr1_244535817_244536354 0.47 0.25 9.3e-03 0.02 0.1 0.04 0.05 1.0e-01 2.5e-03 3.4e-02 2.7e-02
7 PL gene expression LOC134483989 0.09 0.04 2.5e-08 0.06 0.07 0.06 0.06 1.4e-07 1.3e-08 4.4e-07 6.4e-07
8 RMTg gene expression LOC134483989 0.13 0.08 7.6e-03 0.03 0.06 0.05 0.04 5.6e-02 8.3e-03 1.6e-02 3.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.93.44.8-2.11.92.02.01.82.2-1.60.7
Area under the delay curve0.10.10.50.5-0.1-0.0-0.0-0.1-0.70.0-0.6
BMI with tail0.00.10.40.50.00.00.0-0.6-0.10.30.5
BMI without tail0.00.10.30.20.20.30.3-0.1-0.60.0-0.1
Body weight0.73.25.3-2.02.32.22.21.60.4-1.9-0.6
Weight adjusted by age0.00.00.10.2-0.3-0.3-0.30.1-0.10.1-0.2
Bone surface1.22.48.2-1.81.11.21.21.12.9-1.01.3
Bone volume1.83.65.5-2.41.92.12.11.82.2-1.70.5
Breakpoint value in progressive ratio session0.61.01.6-0.51.21.11.10.8-0.6-1.1-1.3
Number of licking bursts0.41.11.41.1-1.1-1.2-1.2-0.9-1.21.0-0.4
Context. condit. distance diff. score3.54.35.9-2.12.42.42.42.1-0.5-2.3-1.6
Locomotion velocity, session 15.56.28.22.6-2.8-2.8-2.8-2.90.82.61.9
Locomotion distance, session 10.60.71.20.8-1.0-0.9-0.9-1.10.10.90.5
Locomotion velocity, session 21.31.63.01.1-1.4-1.4-1.4-1.70.91.10.9
Locomotion distance, session 20.10.10.50.0-0.4-0.3-0.3-0.2-0.70.2-0.4
Locomotion velocity, session 30.40.40.8-0.90.70.70.70.6-0.2-0.6-0.5
Locomotion distance, session 32.32.74.1-2.01.81.71.71.6-0.9-1.6-1.5
Stereotopy head waving bouts, day 30.81.01.60.8-1.1-0.9-0.9-0.91.10.91.3
Stereotopy head waving duration, day 30.70.81.50.7-1.0-0.9-0.9-0.81.20.71.0
Locomotion velocity, session 72.62.84.3-2.01.61.71.71.6-0.0-2.1-1.8
Locomotion distance, session 72.12.64.1-2.01.61.61.61.60.2-2.0-1.6
Stereotopy head waving bouts, day 70.50.50.90.7-0.7-0.7-0.7-0.80.40.91.0
Stereotopy head waving duration, day 70.70.92.30.7-0.7-0.8-0.8-0.81.01.01.5
Locomotion velocity, session 80.20.20.4-0.60.60.50.50.30.5-0.6-0.2
Locomotion distance, session 81.52.22.9-1.41.51.51.51.3-1.1-1.5-1.7
Degree of sensitization distance0.10.10.4-0.1-0.0-0.0-0.00.20.5-0.6-0.7
Degree of sensitization stereotypy0.20.20.90.4-0.2-0.3-0.3-0.40.20.60.9
Conditioned locomotion0.50.61.2-0.70.90.80.81.1-0.8-0.6-0.6
Cocaine response after cond. corrected0.00.00.10.2-0.0-0.2-0.2-0.10.00.30.3
Cocaine response after cond. not corrected0.20.30.5-0.40.70.60.60.6-0.5-0.4-0.5
Cocaine response before conditioning0.40.51.1-0.40.60.70.70.6-0.7-0.8-1.0
Saline control response0.91.24.1-0.10.80.80.80.8-2.0-0.8-1.6
Bone: connectivity density1.11.87.4-1.40.80.90.90.82.7-0.81.2
Bone: cortical apparent density0.91.52.51.6-1.3-1.4-1.4-1.30.41.20.6
Bone: cortical area3.15.17.6-2.82.52.62.62.50.6-2.4-0.9
Bone: cortical porosity0.10.10.3-0.4-0.0-0.1-0.10.30.5-0.4-0.3
Bone: cortical porosity0.20.20.5-0.70.30.30.30.50.7-0.7-0.3
Bone: cortical thickness0.91.52.2-1.01.41.51.51.3-1.0-1.1-1.0
Bone: cortical thickness0.20.21.10.2-0.10.00.0-0.0-1.00.1-0.6
Bone: cortical tissue density1.11.72.81.7-1.4-1.5-1.5-1.40.41.20.7
Condit. Reinf. active minus inactive responses0.10.10.4-0.0-0.3-0.2-0.2-0.2-0.60.2-0.5
Condit. Reinf. active-inactive response ratio0.91.01.50.7-1.2-1.2-1.2-1.00.41.10.8
Condit. Reinf. active responses0.70.91.5-0.80.90.90.90.9-1.0-0.9-1.2
Condit. Reinf. inactive responses1.62.13.0-0.91.71.71.71.5-1.1-1.4-1.3
Incentive salience index mean0.40.62.8-0.20.10.10.10.1-1.7-0.1-1.3
Condit. Reinf. lever presses0.50.84.20.6-0.2-0.2-0.2-0.4-2.10.2-1.1
Condit. Reinf. active minus inactive responses1.42.13.4-1.81.41.41.41.6-0.5-1.6-1.5
Condit. Reinf. active-inactive response ratio0.30.51.0-1.00.60.50.50.9-0.5-0.7-0.8
Condit. Reinf. active responses1.72.53.7-1.71.71.81.81.9-0.4-1.7-1.0
Condit. Reinf. inactive responses0.50.81.5-0.51.11.21.21.0-0.3-0.7-0.1
Condit. Reinf. lever presses0.00.00.10.1-0.00.10.10.1-0.40.10.1
Condit. Reinf. lever reinforcers received1.21.72.6-1.41.41.41.41.6-0.5-1.3-1.0
Conditioned reinforcement - actives0.10.51.8-0.60.50.50.50.61.3-0.40.8
Conditioned reinforcement - inactives0.30.73.5-0.80.40.40.40.51.9-0.70.5
Conditioned locomotion0.60.95.20.0-0.1-0.0-0.00.02.3-0.11.3
Patch foraging indifference point 0 sec0.20.61.10.6-0.7-0.5-0.5-1.00.40.91.0
Patch foraging indifference point AUC0.10.10.20.5-0.4-0.4-0.4-0.2-0.30.2-0.3
Delay disc. indifference point, 0s delay1.92.14.0-0.81.41.51.51.4-1.5-1.4-2.0
Delay disc. indifference point, 16s delay0.00.00.20.3-0.00.00.0-0.00.5-0.00.3
Delay disc. indifference point, 2s delay0.20.30.70.8-0.5-0.4-0.4-0.80.10.40.1
Delay disc. indifference point, 24s delay0.10.10.60.3-0.1-0.0-0.0-0.2-0.6-0.2-0.8
Delay disc. indifference point, 4s delay0.60.61.40.00.70.70.70.4-1.2-0.6-1.2
Delay disc. indifference point, 8s delay0.71.22.01.4-1.3-1.2-1.2-1.1-0.81.1-0.1
Indifference point function ln k0.20.71.5-1.20.81.01.00.60.7-0.80.0
Indifference point function log k0.20.71.5-1.20.81.01.00.60.7-0.80.0
Patch foraging total patch changes 0 sec0.20.51.20.6-0.6-0.5-0.5-1.00.50.91.1
Patch foraging total patch changes 12 sec1.31.73.41.8-1.3-1.3-1.3-1.6-0.51.50.7
Patch foraging total patch changes 18 sec0.30.61.71.3-0.8-0.5-0.5-1.0-0.50.80.3
Patch foraging total patch changes 24 sec0.00.00.1-0.30.20.00.00.2-0.1-0.2-0.3
Patch foraging total patch changes 6 sec1.01.72.41.3-1.4-1.4-1.4-1.60.21.51.2
Patch foraging time to switch 0 sec0.31.12.51.3-0.8-1.0-1.0-0.9-1.61.20.0
Patch foraging water rate 0 sec0.10.51.8-0.90.30.50.50.31.3-0.8-0.0
Patch foraging water rate 12 sec0.10.30.7-0.70.30.50.50.40.8-0.50.2
Patch foraging water rate 18 sec0.41.01.7-1.31.11.11.10.70.6-1.2-0.5
Patch foraging water rate 24 sec1.62.33.5-1.51.81.91.91.5-0.4-1.6-1.1
Patch foraging water rate 6 sec0.30.41.50.2-0.4-0.4-0.4-0.51.20.20.8
Seeking ratio, delayed vs. immediate footshock0.20.30.8-0.50.50.30.30.9-0.5-0.5-0.6
Distance traveled before self-admin0.00.10.3-0.1-0.0-0.2-0.20.0-0.1-0.1-0.6
Distance traveled after self-admin0.50.84.20.2-0.6-0.7-0.7-0.72.10.10.7
Extensor digitorum longus weight1.76.68.1-2.52.72.82.82.5-1.2-2.8-2.7
Bone: elastic displacement3.84.97.02.4-2.6-2.5-2.5-2.50.72.21.5
Bone: elastic work2.63.45.11.7-2.3-2.0-2.0-2.11.41.71.4
Bone: endosteal estimation2.35.711.0-3.22.22.22.22.23.3-2.40.4
Bone: endosteal perimeter2.04.98.3-2.92.22.22.22.12.8-2.10.5
Epididymis fat weight0.21.11.8-1.01.31.31.30.80.7-1.2-0.2
Delta time in closed arm before/after self-admin0.20.20.50.1-0.5-0.4-0.4-0.40.70.20.3
Delta time in open arm before/after self-admin0.00.10.20.1-0.1-0.2-0.2-0.4-0.20.0-0.4
Diff in mean of infusions in LGA sessions0.40.71.1-0.80.80.90.90.70.9-1.0-0.4
Delay discount exponential model param0.10.10.4-0.50.10.00.00.20.6-0.00.6
Extinction: sum of active levers before priming0.61.01.5-1.11.11.11.10.80.4-1.2-0.9
Active lever presses in extinction session 62.92.93.9-1.81.81.61.62.0-0.6-1.8-1.9
Bone: final force1.11.83.5-1.91.41.51.51.50.8-1.3-0.2
Bone: final moment0.71.22.4-1.51.01.11.11.11.3-0.90.3
Food consumed during 24 hour testing period0.00.10.3-0.0-0.2-0.0-0.0-0.5-0.00.30.2
Glucose0.10.10.4-0.50.10.20.20.50.7-0.40.1
Heart weight2.13.58.11.3-1.5-1.4-1.4-1.72.81.42.6
Delay discount hyperbolic model param0.10.10.3-0.60.30.20.20.40.5-0.20.4
Intermittent access intake day 1-15 change0.21.12.4-1.30.80.80.80.91.5-0.21.3
Intermittent access intake escalation0.21.32.4-1.61.11.11.11.21.1-0.50.9
Intermittent access intake escalation 20.40.72.3-1.50.60.60.60.80.9-0.20.7
Intermitt. access day 1 inactive lever presses0.10.81.60.8-1.2-1.2-1.2-0.90.50.70.4
Intermitt. access day 15 inactive lever presses0.21.38.4-0.4-0.1-0.1-0.10.52.9-0.31.4
Intermitt. access escalation Index0.10.31.30.8-0.2-0.1-0.1-0.3-1.20.3-0.3
Intermittent access day 1 total infusions0.20.61.9-0.70.70.70.70.51.4-1.00.1
Intermittent access day 15 total infusions1.02.53.2-1.71.71.71.71.71.8-1.30.8
Intermittent access terminal intake (last 3 days)0.91.54.0-1.31.11.11.11.02.0-0.81.0
Intermittent access total infusions1.11.32.3-1.11.21.31.31.11.5-1.10.4
Intermittent access day 1 locomotion0.20.41.0-0.30.60.60.60.51.0-0.70.2
Intermittent access day 15 total locomotion0.20.83.6-0.30.50.60.60.41.9-0.31.2
Intermittent access total locomotion0.60.82.2-0.60.80.90.90.71.5-0.90.4
Intermittent access standard deviation0.31.55.2-1.50.90.90.91.02.3-0.80.9
Left kidney weight0.21.72.9-1.31.61.71.71.30.3-1.2-0.2
Right kidney weight0.10.81.8-0.81.31.21.20.9-0.3-0.8-0.2
Cocaine induced anxiety0.30.81.3-0.60.90.90.91.1-1.0-0.7-1.0
Post-drug Anxiety0.10.10.40.10.30.20.20.6-0.10.00.3
Baseline Anxiety0.30.51.60.4-0.4-0.4-0.4-0.31.30.41.3
Tail length0.84.15.3-2.32.32.22.22.2-0.3-2.3-1.7
Length with tail1.56.89.6-3.13.13.03.02.80.6-2.9-1.3
Length without tail1.37.010.3-3.03.23.13.12.61.1-3.0-1.1
Times rat made contact with spout0.30.41.30.20.30.50.5-0.2-0.9-0.5-1.1
Lifetime Intake1.01.33.0-1.01.11.11.11.01.7-1.10.5
Liver weight, left0.50.81.3-1.01.11.11.11.10.1-0.9-0.1
Liver weight, right0.81.52.0-1.31.41.41.41.21.2-1.20.1
Locomotor activity0.50.71.40.8-0.9-0.9-0.9-1.20.01.00.5
Locomotor testing distance0.71.72.51.0-1.5-1.5-1.5-1.60.41.40.9
Locomotor testing rearing0.10.40.9-1.00.60.60.60.7-0.3-0.7-0.7
Locomotion in novel chamber0.60.71.2-1.01.01.11.10.7-0.1-0.9-0.4
Locomotion in novel chamber post-restriction1.23.75.6-1.52.42.42.42.2-1.0-1.8-1.3
Fecal boli incidents, locomotor time 10.40.91.3-1.01.00.80.81.2-0.2-1.2-1.1
Change in fecal boli incidents, locomotor task0.20.20.50.7-0.3-0.4-0.4-0.6-0.50.60.2
Time >=10cm from walls, locomotor time 14.65.77.9-2.52.82.72.72.5-0.8-2.4-1.8
Bouts of movement, locomotor time 10.30.41.0-0.20.70.50.50.9-1.0-0.2-0.3
Total resting periods, locomotor time 10.50.51.2-0.20.80.70.71.1-1.0-0.4-0.4
Rest time, locomotor task time 10.10.20.40.6-0.4-0.7-0.70.00.00.40.1
Distance moved, locomotor task time 10.20.50.8-0.80.50.80.80.2-0.4-0.7-0.9
Vertical activity count, locomotor time 10.00.10.2-0.30.00.40.4-0.1-0.10.10.2
Time >=10cm from walls, locomotor time 20.71.92.8-1.51.51.31.31.5-1.0-1.3-1.7
Bouts of movement, locomotor time 20.41.32.31.5-0.7-1.1-1.1-1.2-1.51.1-0.3
Total resting periods, locomotor time 20.31.12.81.2-0.6-1.0-1.0-0.9-1.70.9-0.5
Rest time, locomotor task time 20.50.82.7-0.40.80.50.51.0-1.6-0.4-1.0
Distance moved, locomotor task time 20.40.50.8-0.80.40.80.80.20.4-0.9-0.7
Vertical activity count, locomotor time 20.30.61.50.3-1.0-0.6-0.6-1.11.20.50.5
Light reinforcement 10.00.10.30.3-0.3-0.3-0.3-0.30.10.40.5
Light reinforcement 21.94.36.22.2-2.5-2.5-2.5-2.30.42.11.1
Bone: marrow area2.45.911.4-3.22.22.22.22.23.4-2.40.4
Bone: maximum diameter4.59.014.6-3.83.33.33.33.22.3-3.0-0.2
Bone: maximum force1.32.54.3-2.11.51.71.71.61.7-1.40.3
Bone: maximum moment1.01.94.8-1.81.11.31.31.22.2-1.10.8
Mean time between licks in bursts0.42.43.71.1-1.8-1.9-1.9-1.21.11.61.6
Mean num. licks in bursts0.41.21.7-1.01.21.31.31.00.8-1.3-0.3
Cd content in liver2.62.93.81.6-1.8-1.9-1.9-1.90.51.91.7
Co content in liver3.03.54.41.7-2.0-2.0-2.0-2.11.11.92.0
Cu content in liver4.75.67.22.6-2.5-2.5-2.5-2.71.12.52.1
Fe content in liver1.01.32.21.5-1.0-1.1-1.1-1.1-1.01.40.5
K content in liver0.60.62.10.00.10.10.10.1-1.5-0.4-1.4
Mg content in liver0.30.40.60.7-0.6-0.6-0.6-0.7-0.80.5-0.3
Mn content in liver1.41.53.21.8-1.3-1.2-1.2-1.4-0.81.30.5
Na content in liver0.50.62.90.6-0.3-0.3-0.3-0.1-1.70.2-1.1
Rb content in liver0.20.30.4-0.60.60.60.60.30.5-0.6-0.2
Se content in liver17.520.728.65.2-5.3-5.2-5.2-5.0-1.54.91.8
Sr content in liver2.72.43.11.2-1.7-1.7-1.7-1.31.41.51.8
Zn content in liver2.73.24.82.0-2.1-2.0-2.0-2.2-1.21.6-0.4
Bone: minimum diameter4.99.516.2-4.03.33.33.33.32.4-3.2-0.3
Time in familiar zone, hab. session 10.40.41.20.4-0.4-0.5-0.5-0.61.10.50.9
Time in novel zone, hab. session 10.10.10.4-0.1-0.2-0.1-0.10.0-0.6-0.1-0.7
Total zone transitions, hab. session 10.00.00.0-0.1-0.1-0.0-0.0-0.10.20.00.1
Total locomotion distance, hab. session 10.40.51.60.7-0.7-0.5-0.5-0.8-1.30.6-0.4
Locomotion velocity, hab. session 10.50.83.40.8-0.7-0.4-0.4-0.7-1.80.6-0.7
Time in familiar zone, hab. session 21.21.31.71.0-1.2-1.2-1.2-1.31.01.11.1
Time in novel zone, hab. session 20.10.10.2-0.20.30.30.30.4-0.1-0.3-0.1
Total zone transitions, hab. session 20.50.60.80.7-0.6-0.9-0.9-0.90.10.90.8
Total locomotion distance, hab. session 20.40.50.70.8-0.7-0.8-0.8-0.9-0.50.80.3
Locomotion velocity, hab. session 20.30.41.00.7-0.5-0.5-0.5-0.7-1.00.6-0.2
Novel to familiar place preference ratio0.81.01.7-1.30.81.11.11.10.2-1.2-0.9
Novelty place preference0.70.91.7-1.30.71.01.01.00.4-1.2-0.8
Time in novel zone, NPP test0.70.81.7-1.30.60.90.91.00.6-1.1-0.8
Total zone transitions, NPP test0.10.20.50.2-0.2-0.4-0.4-0.4-0.70.2-0.5
Total locomotion distance, NPP test0.70.92.11.0-1.0-0.9-0.9-0.8-1.40.8-0.5
Locomotion velocity, NPP test0.60.83.10.8-0.7-0.7-0.7-0.6-1.80.5-0.8
Intraocular pressure0.00.10.30.2-0.1-0.0-0.0-0.00.30.20.6
Delta distance traveled before/after self-admin0.70.73.6-0.70.40.50.50.31.9-0.60.6
Delta ambulatory time before/after self-admin0.50.93.8-0.80.60.70.70.51.9-0.80.6
Parametrial fat weight0.20.41.8-0.10.30.20.20.1-1.3-0.4-1.1
Pavlov. Cond. lever latency1.31.74.61.0-0.9-0.9-0.9-0.91.91.22.2
Pavlov. Cond. magazine entry latency0.10.20.50.2-0.4-0.2-0.2-0.7-0.70.3-0.4
Pavlov. Cond. change in total contacts0.20.30.50.2-0.7-0.6-0.6-0.6-0.30.5-0.0
Pavlov. Cond. index score0.81.03.3-0.50.50.60.60.3-1.8-0.6-1.6
Pavlov. Cond. latency score1.31.64.6-0.80.80.90.90.6-2.1-0.9-2.0
Pavlov. Cond. lever contacts0.81.03.3-0.50.50.50.50.5-1.8-0.7-1.7
Pavlov. Cond. magazine entry number0.10.10.4-0.20.40.20.20.70.2-0.40.0
Pavlov. Cond. intertrial magazine entries0.70.91.5-0.61.00.90.91.2-1.1-0.8-0.8
Pavlov. Cond. lever-magazine prob. diff.0.60.83.4-0.30.30.40.40.1-1.9-0.3-1.5
Pavlov. Cond. response bias0.30.30.80.3-0.8-0.6-0.6-0.9-0.30.6-0.0
Pavlov. Cond. lever latency0.30.50.8-0.60.60.60.60.8-0.5-0.7-0.9
Pavlov. Cond. magazine entry latency0.30.40.60.4-0.7-0.8-0.8-0.7-0.40.6-0.1
Pavlov. Cond. change in total contacts0.00.10.4-0.1-0.00.10.1-0.1-0.6-0.2-0.6
Pavlov. Cond. index score0.00.00.1-0.0-0.1-0.1-0.1-0.2-0.30.1-0.2
Pavlov. Cond. latency score0.00.00.1-0.20.00.00.0-0.0-0.2-0.0-0.2
Pavlov. Cond. lever contacts0.30.40.60.6-0.5-0.5-0.5-0.70.50.60.8
Pavlov. Cond. magazine entry number0.30.40.7-0.50.70.80.80.70.8-0.50.4
Pavlov. Cond. intertrial magazine entries1.22.63.6-1.41.81.91.91.7-0.9-1.6-1.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.0-0.1-0.1-0.1-0.2-0.40.1-0.3
Pavlov. Cond. response bias0.30.50.90.6-0.8-0.8-0.8-0.90.10.70.4
Time in closed arm before self-admin0.10.10.40.2-0.0-0.1-0.1-0.3-0.6-0.1-0.6
Time in closed arm after self-admin0.20.30.90.3-0.4-0.3-0.3-0.3-0.9-0.0-1.0
Time in open arm before self-admin0.60.81.30.4-1.1-0.9-0.9-0.50.80.91.1
Time in open arm after self-admin0.30.30.80.2-0.5-0.5-0.5-0.40.60.60.9
Bone: periosteal estimation3.17.412.7-3.62.82.82.82.72.7-2.8-0.0
Bone: periosteal perimeter3.05.99.0-3.02.72.82.82.61.3-2.5-0.6
Bone: post-yield work1.83.25.7-2.42.01.91.92.01.4-1.7-0.0
Progressive ratio test 1 active lever presses0.40.72.9-0.60.60.60.60.41.7-0.51.0
Progressive ratio test 1 breakpoint0.40.62.6-0.60.50.60.60.41.6-0.50.9
Progressive ratio test 1 inactive lever presses0.30.84.2-1.00.20.20.20.42.0-0.60.8
Progressive ratio test 2 active lever presses1.72.46.6-1.61.41.31.31.32.6-1.21.0
Progressive ratio test 2 breakpoint2.02.57.2-1.61.41.41.41.32.7-1.31.1
Progressive ratio test 2 inactive lever presses0.30.95.2-0.60.10.10.10.32.3-0.31.1
Incentive Sensitization - Responses0.71.84.9-1.61.21.11.11.12.2-1.00.8
Incentive Sensitization - Breakpoint0.81.94.9-1.61.31.21.21.22.2-1.10.8
Sum of active levers in priming session hrs 5-61.61.53.21.4-1.2-1.3-1.3-1.80.41.30.8
Progressive ratio0.51.64.1-0.61.21.21.21.4-2.0-0.7-1.2
Food seeking constrained by brief footshock2.02.54.3-2.01.71.81.82.1-0.4-1.4-0.6
Seeking ratio, punishment vs. effort0.20.42.1-0.4-0.3-0.3-0.3-0.41.5-0.00.6
Retroperitoneal fat weight0.00.10.7-0.00.30.10.1-0.20.8-0.50.0
Reaction time number correct0.31.21.9-1.31.41.21.21.2-0.3-1.0-0.6
Reaction time mean minus median0.10.82.30.2-0.7-0.7-0.7-0.71.30.81.5
Reaction time mean minus median AUC0.21.62.90.8-1.3-1.3-1.3-1.21.11.41.7
Reaction time num false alarms1.62.63.5-1.51.91.71.71.6-1.0-1.7-1.6
Reaction time num false alarms AUC0.92.12.7-1.41.61.51.51.5-0.9-1.5-1.5
Reaction time trials correct on left0.31.21.9-1.31.41.21.21.2-0.3-1.0-0.6
Reaction time trials on left0.41.21.9-1.31.41.21.21.2-0.4-1.0-0.6
Reaction time mean1.12.33.31.2-1.8-1.8-1.8-1.71.11.41.2
Reaction time mean AUC1.33.04.31.4-2.1-2.0-2.0-2.01.01.71.4
Median of all reaction times1.62.53.81.3-1.9-1.9-1.9-1.81.01.41.0
Reaction time omissions0.00.10.2-0.4-0.3-0.4-0.40.00.00.20.2
Reaction time false alarm rate0.60.81.0-0.71.00.90.90.9-0.7-1.0-1.0
Reaction time premature initiation rate0.81.31.9-1.01.41.41.41.1-0.8-1.0-0.8
Reaction time premature initiations1.13.45.4-1.92.32.22.22.0-1.0-1.6-1.1
Std. dev. reaction times0.62.03.30.8-1.4-1.4-1.4-1.41.51.41.8
Reaction time trials completed0.41.21.9-1.31.41.21.21.2-0.4-1.0-0.6
Reaction time trials AUC0.31.11.7-1.21.31.11.11.1-0.5-1.0-0.8
Run reversals in cocaine runway, females1.01.11.70.9-1.3-1.2-1.2-1.20.81.00.8
Run reversals in cocaine runway, males0.20.21.50.5-0.0-0.0-0.00.4-1.20.3-0.1
Latency to leave start box in cocaine runway0.40.60.9-0.90.90.90.90.60.1-0.8-0.4
Latency to leave start box in cocaine runway, F0.50.61.2-1.10.80.70.70.70.2-0.9-0.6
Latency to leave start box in cocaine runway, M0.10.10.2-0.20.40.40.4-0.1-0.2-0.20.0
Std. dev. time between licks in bursts1.63.03.91.9-1.9-2.0-2.0-1.80.51.81.4
Total sessions with >9 infusions0.50.61.61.0-0.5-0.5-0.5-0.71.30.30.9
Short access day 1 total inactive lever presses0.30.63.7-0.2-0.3-0.3-0.3-0.11.9-0.01.0
Short access day 10 total inactive lever presses0.00.20.70.0-0.1-0.1-0.10.3-0.8-0.1-0.9
Short access day 1 total infusions0.30.51.30.7-0.7-0.6-0.6-0.51.20.40.8
Short access day 10 total infusions0.60.92.00.7-0.9-0.9-0.9-0.91.40.51.1
Short access total infusions0.40.53.5-0.10.00.10.10.11.9-0.40.8
Short access day 1 locomotion0.40.70.90.9-0.9-0.8-0.8-1.01.00.40.5
Short access day 10 total locomotion0.10.40.70.6-0.8-0.7-0.7-0.9-0.20.50.0
Short access total locomotion1.42.13.01.7-1.6-1.6-1.6-1.71.31.00.9
One hour access (0.3 mA shock)3.44.16.9-2.52.02.02.01.92.6-1.70.9
Compulsive drug intake0.30.40.8-0.80.60.60.60.90.2-0.8-0.4
One hour access (shock baseline)0.61.62.6-1.41.31.31.31.11.6-1.00.7
Social response proportion0.30.42.1-0.2-0.3-0.6-0.6-0.21.50.10.7
Social responses0.70.94.9-0.3-0.1-0.3-0.3-0.02.20.01.3
Social time0.20.20.60.3-0.7-0.8-0.8-0.1-0.00.40.1
Soleus weight0.61.67.2-1.60.50.60.60.82.7-1.00.8
Bone: stiffness3.56.49.7-3.12.82.82.83.10.5-2.7-1.2
Tibialis anterior weight2.58.711.4-3.02.93.03.03.1-1.7-3.2-3.4
Time to tail flick, vehicle, before self-admin1.61.92.91.5-1.7-1.7-1.7-1.30.51.20.9
Time to tail flick, vehicle, after self-admin2.14.37.3-1.71.92.02.02.2-1.7-2.1-2.7
Time to tail flick, test, before self-admin0.91.01.7-1.21.11.01.00.61.1-1.3-0.5
Time to tail flick, test, after self-admin0.50.51.00.6-1.0-0.9-0.9-0.8-0.10.4-0.4
Delta time to tail flick, vehicle, before/after SA10.611.313.8-3.13.63.63.63.7-2.3-3.3-3.5
Delta time to tail flick, test, before/after SA0.40.50.80.8-0.9-0.8-0.8-0.4-0.70.8-0.1
Tibia length0.00.10.3-0.20.40.50.5-0.30.3-0.10.3
Ambulatory time before self-admin0.10.20.50.4-0.6-0.7-0.7-0.4-0.20.3-0.3
Ambulatory time after self-admin0.30.53.5-0.2-0.2-0.2-0.2-0.41.9-0.30.3
Bone: tissue strength0.91.03.50.2-0.9-0.9-0.9-0.61.90.51.2
Total heroin consumption0.81.01.7-0.91.31.31.30.80.0-1.1-0.7
Bone: trabecular number1.01.85.3-1.31.21.21.20.92.3-0.91.2
Bone: trabecular spacing0.40.62.90.5-0.4-0.5-0.5-0.3-1.70.4-0.9
Bone: trabecular thickness1.21.73.0-1.51.31.41.41.01.7-1.20.5
Bone: trabecular tissue density0.50.81.4-0.81.11.21.20.90.2-1.0-0.4
Water consumed over 24 hours0.51.03.3-0.70.70.90.90.4-1.1-1.1-1.8
Number of responses in last shaping day1.72.25.11.7-1.1-1.1-1.1-1.01.71.42.3