Hub : Genes

LOC134483971

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression LOC134483971 0.33 0.16 5.5e-06 0.17 0.15 0.19 0.19 7.9e-05 1.9e-04 3.5e-05 3.4e-05
2 NAcc gene expression LOC134483971 0.48 0.08 0.0e+00 0.7 0.72 0.72 0.72 8.8e-150 1.6e-157 8.8e-158 6.5e-157
3 IL gene expression LOC134483971 0.23 0.13 6.8e-04 0.09 0.11 0.01 0.07 3.9e-03 1.2e-03 1.4e-01 9.8e-03
4 NAcc mRNA stability LOC134483971 0.01 0.01 5.3e-03 0.02 0.02 0.02 0.02 1.4e-03 1.3e-03 1.2e-03 1.4e-03
5 pVTA gene expression LOC134483971 0.09 0.05 4.4e-07 0.07 0.08 0.08 0.07 4.3e-06 3.3e-07 6.2e-07 2.7e-06
6 BLA gene expression LOC134483971 0.22 0.1 4.0e-12 0.21 0.24 0.24 0.23 2.0e-11 8.0e-13 1.0e-12 1.1e-12
7 Brain gene expression LOC134483971 0.74 0 0.0e+00 0.56 0.55 0.56 0.57 9.4e-63 2.5e-61 4.3e-63 1.5e-63
8 PL gene expression LOC134483971 0.19 0.09 2.4e-15 0.1 0.14 0.13 0.13 4.9e-11 5.2e-15 7.8e-14 6.4e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.20.30.5-0.6-0.4-0.5-0.5-0.7-0.6-0.3-0.6
Area under the delay curve0.00.00.2-0.10.0-0.1-0.1-0.4-0.30.1-0.2
BMI with tail4.314.820.0-2.9-3.8-3.9-3.5-4.1-4.2-3.8-4.5
BMI without tail0.92.83.6-1.2-1.5-1.7-1.7-1.8-1.8-1.6-1.9
Body weight4.017.720.8-3.9-4.1-4.3-3.9-4.6-4.5-3.9-4.4
Weight adjusted by age2.23.34.5-1.3-2.0-1.9-1.7-1.6-1.8-2.1-2.0
Bone surface1.12.03.6-1.9-1.3-1.4-1.1-1.7-1.5-1.0-1.2
Bone volume0.40.71.3-1.1-0.7-0.8-0.5-1.1-0.9-0.4-0.8
Breakpoint value in progressive ratio session2.02.53.7-1.9-1.7-1.6-1.7-1.4-1.3-1.6-1.1
Number of licking bursts0.10.10.20.0-0.1-0.3-0.3-0.4-0.4-0.1-0.4
Context. condit. distance diff. score0.00.10.10.3-0.2-0.2-0.1-0.2-0.3-0.2-0.4
Locomotion velocity, session 10.20.20.4-0.2-0.6-0.3-0.5-0.0-0.2-0.6-0.5
Locomotion distance, session 11.31.62.3-1.0-1.5-1.2-1.4-1.0-1.2-1.5-1.4
Locomotion velocity, session 23.13.63.8-1.9-1.9-1.9-1.7-1.9-1.9-1.9-1.8
Locomotion distance, session 20.91.32.1-0.7-1.2-1.1-1.3-0.9-1.0-1.5-1.2
Locomotion velocity, session 31.01.22.1-0.5-0.9-1.1-0.7-1.4-1.4-0.9-1.5
Locomotion distance, session 30.20.20.5-0.00.60.40.50.30.40.70.6
Stereotopy head waving bouts, day 30.30.30.80.2-0.4-0.5-0.4-0.6-0.7-0.6-0.9
Stereotopy head waving duration, day 30.40.51.00.1-0.6-0.7-0.6-0.8-0.9-0.8-1.0
Locomotion velocity, session 70.00.00.1-0.10.1-0.10.0-0.3-0.20.1-0.1
Locomotion distance, session 70.00.00.00.10.1-0.10.1-0.2-0.2-0.0-0.2
Stereotopy head waving bouts, day 70.20.20.3-0.5-0.5-0.5-0.4-0.5-0.5-0.4-0.5
Stereotopy head waving duration, day 71.01.22.0-1.4-1.1-1.1-1.0-1.1-1.0-1.0-0.8
Locomotion velocity, session 80.10.20.40.00.40.30.30.40.50.30.7
Locomotion distance, session 80.10.20.40.3-0.3-0.3-0.3-0.3-0.4-0.5-0.6
Degree of sensitization distance1.31.32.7-0.1-1.1-1.1-1.0-1.1-1.3-1.3-1.6
Degree of sensitization stereotypy1.01.01.5-1.2-1.1-1.0-0.9-1.0-1.0-1.0-0.9
Conditioned locomotion0.60.70.8-0.8-0.8-0.9-0.9-0.9-0.9-0.8-0.8
Cocaine response after cond. corrected0.20.20.50.7-0.3-0.2-0.40.0-0.3-0.5-0.7
Cocaine response after cond. not corrected0.10.10.30.5-0.3-0.1-0.20.2-0.1-0.4-0.6
Cocaine response before conditioning0.10.10.6-0.8-0.10.10.40.20.30.20.4
Saline control response1.72.24.4-2.1-1.6-1.5-1.5-1.4-1.2-1.4-1.0
Bone: connectivity density1.32.02.6-1.6-1.4-1.4-1.4-1.5-1.4-1.2-1.3
Bone: cortical apparent density0.10.10.5-0.7-0.4-0.3-0.4-0.2-0.2-0.40.0
Bone: cortical area0.20.31.3-1.1-0.4-0.4-0.2-0.5-0.4-0.1-0.2
Bone: cortical porosity0.00.00.1-0.10.0-0.0-0.10.10.2-0.10.3
Bone: cortical porosity0.00.10.1-0.3-0.2-0.2-0.3-0.1-0.0-0.30.1
Bone: cortical thickness1.11.85.4-2.3-1.4-1.3-1.5-1.0-0.8-1.2-0.5
Bone: cortical thickness0.00.10.3-0.5-0.0-0.1-0.20.10.20.00.3
Bone: cortical tissue density0.20.30.7-0.9-0.6-0.5-0.6-0.4-0.3-0.6-0.1
Condit. Reinf. active minus inactive responses1.61.82.5-1.2-1.6-1.3-1.4-1.0-1.2-1.5-1.4
Condit. Reinf. active-inactive response ratio0.91.01.7-0.8-1.3-0.9-1.3-0.4-0.7-1.3-0.9
Condit. Reinf. active responses1.82.22.9-1.2-1.7-1.5-1.4-1.2-1.4-1.6-1.7
Condit. Reinf. inactive responses0.20.20.6-0.0-0.4-0.4-0.1-0.5-0.6-0.3-0.8
Incentive salience index mean1.21.51.9-1.2-1.4-1.2-1.1-1.1-1.2-1.2-1.3
Condit. Reinf. lever presses0.30.40.8-0.9-0.6-0.6-0.2-0.8-0.7-0.4-0.7
Condit. Reinf. active minus inactive responses0.00.00.10.1-0.2-0.0-0.30.1-0.1-0.1-0.3
Condit. Reinf. active-inactive response ratio0.30.41.20.4-0.5-0.5-0.4-0.6-0.8-0.5-1.1
Condit. Reinf. active responses0.10.10.2-0.4-0.4-0.2-0.4-0.1-0.2-0.2-0.3
Condit. Reinf. inactive responses0.40.50.9-0.40.40.60.40.80.90.71.0
Condit. Reinf. lever presses1.11.51.8-1.2-1.3-1.2-1.1-1.3-1.3-1.0-1.3
Condit. Reinf. lever reinforcers received0.30.40.6-0.7-0.7-0.5-0.8-0.4-0.5-0.5-0.6
Conditioned reinforcement - actives0.10.10.20.20.10.30.40.50.40.30.2
Conditioned reinforcement - inactives0.10.20.5-0.1-0.4-0.4-0.1-0.5-0.6-0.3-0.7
Conditioned locomotion0.81.12.01.41.11.01.30.80.71.10.5
Patch foraging indifference point 0 sec0.20.40.7-0.8-0.7-0.6-0.5-0.7-0.6-0.7-0.4
Patch foraging indifference point AUC0.50.81.9-1.4-0.9-0.8-0.9-0.8-0.7-0.8-0.5
Delay disc. indifference point, 0s delay0.20.20.60.5-0.0-0.2-0.0-0.4-0.50.1-0.8
Delay disc. indifference point, 16s delay0.10.10.1-0.3-0.3-0.2-0.1-0.4-0.3-0.2-0.2
Delay disc. indifference point, 2s delay0.20.20.50.50.60.50.70.10.20.70.2
Delay disc. indifference point, 24s delay0.00.00.0-0.10.1-0.0-0.1-0.2-0.10.10.0
Delay disc. indifference point, 4s delay0.20.20.5-0.4-0.1-0.4-0.3-0.7-0.5-0.1-0.4
Delay disc. indifference point, 8s delay0.30.40.70.70.80.60.60.40.50.70.7
Indifference point function ln k1.12.05.42.31.41.31.51.21.01.30.6
Indifference point function log k1.12.05.42.31.41.31.51.21.01.30.6
Patch foraging total patch changes 0 sec0.20.30.6-0.8-0.6-0.6-0.4-0.5-0.4-0.6-0.3
Patch foraging total patch changes 12 sec4.45.68.8-3.0-2.5-2.4-2.4-2.2-2.1-2.5-1.7
Patch foraging total patch changes 18 sec0.30.41.0-1.0-0.7-0.6-0.8-0.4-0.4-0.6-0.3
Patch foraging total patch changes 24 sec4.17.08.4-2.9-2.7-2.7-2.6-2.8-2.6-2.5-2.4
Patch foraging total patch changes 6 sec0.50.71.4-1.2-0.8-0.9-0.6-1.0-0.8-0.7-0.6
Patch foraging time to switch 0 sec0.30.71.0-0.7-0.8-0.8-0.5-1.0-1.0-0.6-1.0
Patch foraging water rate 0 sec0.71.51.90.91.21.21.21.31.41.11.4
Patch foraging water rate 12 sec1.02.13.11.71.51.51.41.51.41.31.2
Patch foraging water rate 18 sec0.50.81.00.91.00.91.00.80.80.90.8
Patch foraging water rate 24 sec1.21.72.01.41.31.31.31.31.31.21.2
Patch foraging water rate 6 sec1.21.72.01.31.41.31.11.31.41.21.3
Seeking ratio, delayed vs. immediate footshock0.30.30.7-0.2-0.4-0.6-0.4-0.7-0.8-0.3-0.8
Distance traveled before self-admin1.72.23.2-1.8-1.5-1.5-1.3-1.6-1.5-1.3-1.4
Distance traveled after self-admin0.40.50.7-0.8-0.7-0.7-0.9-0.6-0.6-0.7-0.6
Extensor digitorum longus weight6.525.727.1-5.1-5.1-5.2-5.1-5.1-5.0-5.0-4.8
Bone: elastic displacement0.50.61.10.70.60.70.41.01.00.40.9
Bone: elastic work0.40.51.1-1.0-0.7-0.7-0.9-0.4-0.4-0.7-0.3
Bone: endosteal estimation0.51.02.31.51.10.81.40.30.31.20.1
Bone: endosteal perimeter0.81.83.71.91.51.21.90.60.51.60.4
Epididymis fat weight0.30.92.01.41.00.91.40.40.31.10.2
Delta time in closed arm before/after self-admin2.42.33.2-1.2-1.5-1.6-1.8-1.4-1.4-1.5-1.5
Delta time in open arm before/after self-admin1.91.92.3-1.5-1.5-1.4-1.3-1.3-1.3-1.4-1.2
Diff in mean of infusions in LGA sessions2.22.73.3-1.8-1.7-1.7-1.8-1.6-1.5-1.6-1.4
Delay discount exponential model param0.00.00.20.1-0.00.10.00.40.3-0.10.1
Extinction: sum of active levers before priming3.03.34.2-2.0-1.8-1.8-1.7-1.9-1.8-1.9-1.4
Active lever presses in extinction session 61.81.83.2-1.8-1.5-1.3-1.1-1.3-1.2-1.4-0.9
Bone: final force0.81.32.5-1.6-1.1-1.1-0.8-1.2-1.1-0.9-1.0
Bone: final moment0.81.32.5-1.6-1.1-1.1-0.8-1.2-1.1-0.9-1.0
Food consumed during 24 hour testing period0.40.60.80.40.70.80.80.90.90.80.8
Glucose1.21.84.12.01.41.41.41.21.11.30.6
Heart weight0.10.20.50.70.2-0.10.2-0.4-0.50.2-0.6
Delay discount hyperbolic model param0.00.00.10.0-0.20.0-0.10.30.2-0.20.1
Intermittent access intake day 1-15 change0.91.92.21.21.31.51.51.41.41.41.3
Intermittent access intake escalation1.02.02.31.41.31.51.51.51.41.41.3
Intermittent access intake escalation 20.40.50.60.50.60.70.80.70.70.70.6
Intermitt. access day 1 inactive lever presses0.10.20.60.80.30.40.40.50.30.30.2
Intermitt. access day 15 inactive lever presses1.02.03.1-1.2-1.3-1.4-0.8-1.6-1.7-1.2-1.8
Intermitt. access escalation Index0.71.01.21.11.11.01.00.80.91.00.9
Intermittent access day 1 total infusions0.40.72.10.2-0.4-0.6-0.1-1.0-1.2-0.4-1.4
Intermittent access day 15 total infusions1.11.73.01.71.31.31.71.00.81.40.6
Intermittent access terminal intake (last 3 days)0.10.20.40.60.20.20.6-0.2-0.30.3-0.6
Intermittent access total infusions0.20.20.50.70.20.20.6-0.2-0.40.3-0.6
Intermittent access day 1 locomotion0.60.81.9-0.1-0.7-0.8-0.4-1.0-1.2-0.7-1.4
Intermittent access day 15 total locomotion0.50.92.3-0.2-0.8-0.8-0.3-1.1-1.2-0.7-1.5
Intermittent access total locomotion0.81.03.0-0.0-0.7-0.8-0.1-1.2-1.4-0.6-1.7
Intermittent access standard deviation0.10.20.40.70.40.50.50.60.50.40.3
Left kidney weight0.10.30.60.60.70.40.8-0.1-0.10.8-0.1
Right kidney weight0.00.10.20.50.40.20.5-0.1-0.10.4-0.2
Cocaine induced anxiety0.00.00.1-0.2-0.3-0.2-0.10.0-0.0-0.2-0.1
Post-drug Anxiety0.30.30.4-0.6-0.6-0.6-0.5-0.5-0.6-0.6-0.7
Baseline Anxiety0.20.20.4-0.5-0.4-0.5-0.5-0.6-0.5-0.4-0.5
Tail length0.10.31.1-1.1-0.4-0.5-0.8-0.4-0.2-0.20.0
Length with tail0.94.16.9-2.6-1.9-2.1-2.1-2.2-1.9-1.6-1.6
Length without tail2.58.110.8-3.3-2.9-2.9-2.8-2.9-2.7-2.7-2.6
Times rat made contact with spout0.10.10.5-0.4-0.4-0.3-0.7-0.1-0.1-0.3-0.1
Lifetime Intake0.10.20.50.60.1-0.00.4-0.3-0.50.1-0.7
Liver weight, left0.71.21.71.31.11.10.91.21.11.01.0
Liver weight, right1.12.02.41.51.41.51.41.51.41.41.1
Locomotor activity1.01.62.21.01.31.30.91.41.51.11.4
Locomotor testing distance0.71.21.81.11.11.20.81.31.30.91.1
Locomotor testing rearing0.61.22.01.11.01.20.81.41.30.91.0
Locomotion in novel chamber1.31.72.51.31.41.41.61.11.11.31.1
Locomotion in novel chamber post-restriction1.11.72.51.61.31.31.11.41.31.21.2
Fecal boli incidents, locomotor time 10.00.00.20.2-0.2-0.0-0.10.1-0.10.1-0.5
Change in fecal boli incidents, locomotor task1.81.82.31.31.51.31.51.11.21.41.2
Time >=10cm from walls, locomotor time 10.50.61.91.40.60.71.00.50.30.70.1
Bouts of movement, locomotor time 10.70.81.8-0.9-1.1-0.9-1.3-0.5-0.6-0.8-0.7
Total resting periods, locomotor time 10.50.51.1-0.8-0.9-0.7-1.0-0.5-0.5-0.5-0.6
Rest time, locomotor task time 10.91.12.01.41.01.01.10.90.81.10.6
Distance moved, locomotor task time 10.10.10.3-0.6-0.3-0.3-0.2-0.4-0.3-0.6-0.1
Vertical activity count, locomotor time 10.61.42.20.91.21.21.31.21.30.91.5
Time >=10cm from walls, locomotor time 20.20.20.30.30.40.50.50.50.50.50.5
Bouts of movement, locomotor time 23.14.96.5-1.4-2.5-2.3-2.4-1.8-2.2-2.4-2.6
Total resting periods, locomotor time 22.44.36.3-1.0-2.3-2.1-2.2-1.7-2.1-2.2-2.5
Rest time, locomotor task time 20.70.93.51.90.80.90.70.90.60.60.3
Distance moved, locomotor task time 20.10.20.5-0.70.10.20.20.20.40.20.7
Vertical activity count, locomotor time 21.11.53.50.31.11.21.11.21.50.91.9
Light reinforcement 10.10.30.50.20.40.60.50.70.70.60.5
Light reinforcement 20.20.41.00.40.70.50.90.20.31.00.3
Bone: marrow area0.61.32.81.71.31.01.60.50.51.40.3
Bone: maximum diameter0.10.10.3-0.4-0.0-0.20.2-0.5-0.40.2-0.3
Bone: maximum force1.62.84.1-2.0-1.6-1.7-1.2-2.0-1.8-1.3-1.7
Bone: maximum moment1.62.84.1-2.0-1.6-1.7-1.2-1.9-1.8-1.3-1.6
Mean time between licks in bursts0.30.71.4-0.2-0.9-0.8-1.0-0.6-0.8-1.2-0.9
Mean num. licks in bursts0.10.10.40.00.10.30.10.70.60.10.5
Cd content in liver0.80.91.10.80.91.01.11.01.00.90.9
Co content in liver1.21.31.90.91.21.11.01.31.31.01.4
Cu content in liver0.10.20.30.10.50.30.40.30.40.40.5
Fe content in liver0.00.00.00.1-0.0-0.10.0-0.1-0.1-0.0-0.1
K content in liver0.20.20.4-0.5-0.4-0.5-0.2-0.6-0.6-0.4-0.5
Mg content in liver0.00.00.0-0.0-0.00.0-0.0-0.1-0.1-0.1-0.2
Mn content in liver2.72.93.4-1.8-1.7-1.8-1.6-1.8-1.7-1.7-1.5
Na content in liver0.10.10.3-0.6-0.4-0.2-0.3-0.1-0.2-0.3-0.3
Rb content in liver2.32.73.61.91.71.71.61.71.61.61.4
Se content in liver0.30.40.6-0.4-0.6-0.6-0.4-0.8-0.8-0.5-0.7
Sr content in liver5.64.85.9-2.2-2.3-2.2-2.4-2.0-2.0-2.3-2.0
Zn content in liver2.52.83.5-1.9-1.7-1.7-1.7-1.6-1.5-1.8-1.4
Bone: minimum diameter0.30.51.11.00.80.61.00.20.20.90.0
Time in familiar zone, hab. session 10.00.00.1-0.3-0.3-0.2-0.1-0.2-0.2-0.1-0.2
Time in novel zone, hab. session 11.31.31.61.31.11.21.11.31.21.01.0
Total zone transitions, hab. session 10.10.20.4-0.6-0.5-0.4-0.6-0.3-0.3-0.5-0.2
Total locomotion distance, hab. session 10.20.30.70.0-0.5-0.5-0.5-0.5-0.7-0.6-0.8
Locomotion velocity, hab. session 10.60.91.2-0.6-1.0-0.9-1.0-0.9-1.0-1.1-1.1
Time in familiar zone, hab. session 21.11.21.50.71.01.11.01.21.21.11.2
Time in novel zone, hab. session 21.01.01.2-0.9-1.0-1.0-0.9-1.0-1.0-1.0-1.1
Total zone transitions, hab. session 20.60.81.5-1.2-1.0-0.8-1.0-0.7-0.7-0.9-0.7
Total locomotion distance, hab. session 20.40.50.7-0.4-0.8-0.6-0.8-0.5-0.7-0.8-0.8
Locomotion velocity, hab. session 20.20.30.6-0.2-0.6-0.5-0.6-0.5-0.6-0.6-0.7
Novel to familiar place preference ratio1.51.62.2-1.4-1.1-1.4-1.2-1.5-1.3-1.1-1.1
Novelty place preference0.91.01.5-1.1-0.8-1.1-0.9-1.2-1.1-0.9-0.9
Time in novel zone, NPP test1.51.62.0-1.2-1.1-1.3-1.2-1.4-1.3-1.2-1.2
Total zone transitions, NPP test0.81.11.8-1.3-1.2-1.0-1.2-0.8-0.7-1.3-0.7
Total locomotion distance, NPP test0.10.10.2-0.4-0.4-0.3-0.4-0.2-0.2-0.4-0.2
Locomotion velocity, NPP test0.00.00.1-0.20.00.10.00.10.2-0.00.3
Intraocular pressure0.00.00.10.3-0.00.0-0.20.20.1-0.00.0
Delta distance traveled before/after self-admin0.30.30.70.80.50.50.20.70.60.30.5
Delta ambulatory time before/after self-admin0.50.61.11.00.70.80.41.00.90.60.8
Parametrial fat weight1.22.95.61.92.01.62.40.70.92.21.1
Pavlov. Cond. lever latency0.30.31.01.00.60.50.30.60.50.40.4
Pavlov. Cond. magazine entry latency0.81.11.4-1.2-1.1-1.0-0.7-1.1-1.1-0.9-1.1
Pavlov. Cond. change in total contacts0.20.20.6-0.7-0.6-0.4-0.2-0.4-0.4-0.4-0.4
Pavlov. Cond. index score0.30.30.9-0.9-0.7-0.5-0.3-0.6-0.5-0.4-0.4
Pavlov. Cond. latency score0.10.20.7-0.8-0.5-0.4-0.1-0.4-0.3-0.2-0.3
Pavlov. Cond. lever contacts0.10.10.4-0.7-0.3-0.20.1-0.3-0.2-0.1-0.1
Pavlov. Cond. magazine entry number0.50.61.21.10.90.80.70.80.70.70.6
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.30.20.30.00.50.50.10.6
Pavlov. Cond. lever-magazine prob. diff.0.30.40.9-0.9-0.8-0.6-0.4-0.6-0.6-0.5-0.5
Pavlov. Cond. response bias0.60.71.3-1.1-1.0-0.8-0.6-0.8-0.8-0.7-0.7
Pavlov. Cond. lever latency1.52.13.01.01.51.41.51.41.51.31.7
Pavlov. Cond. magazine entry latency7.38.810.4-3.0-3.2-3.0-3.0-2.8-2.9-3.0-2.9
Pavlov. Cond. change in total contacts1.82.93.8-1.7-1.9-1.7-1.7-1.6-1.7-1.6-1.9
Pavlov. Cond. index score4.86.57.5-2.3-2.7-2.6-2.5-2.5-2.6-2.4-2.7
Pavlov. Cond. latency score4.76.27.2-2.2-2.6-2.5-2.5-2.4-2.6-2.3-2.7
Pavlov. Cond. lever contacts1.52.13.0-1.0-1.6-1.4-1.5-1.3-1.5-1.3-1.7
Pavlov. Cond. magazine entry number11.113.715.63.64.03.83.83.53.73.63.6
Pavlov. Cond. intertrial magazine entries2.13.13.51.51.81.81.71.81.91.71.9
Pavlov. Cond. lever-magazine prob. diff.5.27.08.2-2.5-2.9-2.7-2.6-2.5-2.7-2.5-2.8
Pavlov. Cond. response bias3.75.06.0-1.9-2.4-2.2-2.3-2.1-2.3-2.1-2.4
Time in closed arm before self-admin0.10.10.40.10.30.30.50.20.20.60.2
Time in closed arm after self-admin0.50.60.80.80.80.80.70.70.70.90.6
Time in open arm before self-admin1.51.72.31.21.41.31.01.41.41.01.5
Time in open arm after self-admin0.10.20.3-0.6-0.3-0.4-0.5-0.2-0.2-0.60.0
Bone: periosteal estimation0.10.20.50.20.40.10.7-0.3-0.20.6-0.1
Bone: periosteal perimeter0.00.10.30.00.20.20.5-0.1-0.00.4-0.1
Bone: post-yield work0.10.20.50.20.30.10.7-0.5-0.40.6-0.3
Progressive ratio test 1 active lever presses0.00.00.10.30.10.00.2-0.1-0.20.1-0.2
Progressive ratio test 1 breakpoint0.00.00.10.30.00.00.1-0.1-0.20.0-0.3
Progressive ratio test 1 inactive lever presses2.23.24.2-1.3-1.8-1.8-1.5-1.9-2.0-1.8-2.1
Progressive ratio test 2 active lever presses0.10.20.40.60.30.30.70.1-0.00.5-0.2
Progressive ratio test 2 breakpoint0.10.10.40.60.30.30.6-0.0-0.10.4-0.3
Progressive ratio test 2 inactive lever presses0.10.10.30.3-0.0-0.00.4-0.3-0.40.1-0.6
Incentive Sensitization - Responses0.81.22.0-0.7-1.0-1.1-0.8-1.2-1.3-0.9-1.4
Incentive Sensitization - Breakpoint0.81.01.8-0.6-0.9-1.0-0.6-1.2-1.2-0.8-1.4
Sum of active levers in priming session hrs 5-60.40.31.0-1.0-0.7-0.5-0.6-0.4-0.3-0.7-0.1
Progressive ratio0.10.20.50.0-0.3-0.4-0.0-0.6-0.6-0.1-0.7
Food seeking constrained by brief footshock0.00.00.10.30.10.10.10.20.10.2-0.0
Seeking ratio, punishment vs. effort0.00.00.10.10.10.1-0.20.30.2-0.10.2
Retroperitoneal fat weight2.29.315.53.93.43.13.62.32.33.22.1
Reaction time number correct0.10.10.6-0.8-0.4-0.3-0.5-0.1-0.0-0.1-0.0
Reaction time mean minus median0.20.50.9-0.9-1.0-0.7-0.7-0.5-0.5-0.9-0.4
Reaction time mean minus median AUC0.10.20.3-0.5-0.6-0.3-0.50.10.0-0.60.1
Reaction time num false alarms0.40.50.80.60.80.70.40.80.80.70.9
Reaction time num false alarms AUC0.20.20.60.10.50.40.10.50.60.40.8
Reaction time trials correct on left0.10.10.6-0.8-0.4-0.3-0.5-0.1-0.0-0.1-0.0
Reaction time trials on left0.10.20.7-0.8-0.4-0.3-0.5-0.1-0.0-0.1-0.0
Reaction time mean0.10.10.3-0.1-0.5-0.2-0.30.1-0.1-0.6-0.2
Reaction time mean AUC0.00.00.10.1-0.30.0-0.00.30.1-0.30.0
Median of all reaction times0.10.10.3-0.1-0.5-0.3-0.3-0.1-0.2-0.6-0.3
Reaction time omissions0.10.20.6-0.8-0.5-0.4-0.6-0.2-0.2-0.50.0
Reaction time false alarm rate0.20.30.50.60.70.50.40.50.60.50.7
Reaction time premature initiation rate3.04.26.0-2.4-1.9-2.2-1.4-2.4-2.2-1.8-1.9
Reaction time premature initiations2.54.48.0-2.8-2.0-2.2-1.7-2.3-2.0-1.8-1.7
Std. dev. reaction times0.00.10.2-0.0-0.20.2-0.00.40.4-0.20.4
Reaction time trials completed0.10.20.7-0.8-0.4-0.3-0.5-0.1-0.0-0.1-0.0
Reaction time trials AUC0.10.10.5-0.7-0.3-0.2-0.5-0.00.0-0.1-0.0
Run reversals in cocaine runway, females0.30.30.6-0.4-0.3-0.5-0.3-0.8-0.7-0.5-0.6
Run reversals in cocaine runway, males1.91.92.80.91.51.41.31.31.51.41.7
Latency to leave start box in cocaine runway0.40.51.00.60.80.61.00.20.31.00.3
Latency to leave start box in cocaine runway, F0.10.10.2-0.2-0.1-0.20.1-0.5-0.40.1-0.4
Latency to leave start box in cocaine runway, M2.42.22.91.61.61.51.61.21.31.71.2
Std. dev. time between licks in bursts0.20.30.40.70.50.50.70.50.50.50.4
Total sessions with >9 infusions0.10.10.50.70.00.00.1-0.0-0.2-0.1-0.4
Short access day 1 total inactive lever presses0.00.00.10.1-0.0-0.1-0.1-0.3-0.3-0.1-0.3
Short access day 10 total inactive lever presses0.10.20.60.80.30.40.10.70.50.10.3
Short access day 1 total infusions0.40.51.31.10.70.70.70.60.50.60.4
Short access day 10 total infusions0.30.41.30.2-0.4-0.4-0.0-0.7-0.9-0.4-1.1
Short access total infusions0.10.10.40.6-0.0-0.10.2-0.3-0.4-0.1-0.6
Short access day 1 locomotion0.00.00.10.30.10.10.20.00.00.20.0
Short access day 10 total locomotion0.81.53.4-0.3-1.1-1.2-0.8-1.3-1.5-1.2-1.9
Short access total locomotion0.50.61.6-0.0-0.7-0.7-0.4-0.9-1.0-0.7-1.3
One hour access (0.3 mA shock)0.20.30.70.90.50.40.80.1-0.00.6-0.2
Compulsive drug intake0.40.51.0-0.6-0.7-0.7-1.0-0.4-0.4-0.9-0.4
One hour access (shock baseline)1.52.34.01.71.61.52.01.11.11.80.9
Social response proportion0.50.61.0-0.10.80.70.90.50.81.01.0
Social responses0.60.71.6-0.10.80.70.70.81.00.91.3
Social time0.20.30.60.10.30.40.00.80.80.30.8
Soleus weight2.98.49.83.12.93.02.83.02.92.82.6
Bone: stiffness0.20.30.8-0.9-0.4-0.5-0.2-0.7-0.6-0.2-0.4
Tibialis anterior weight8.127.634.2-5.9-5.5-5.3-5.5-5.0-4.8-5.5-4.4
Time to tail flick, vehicle, before self-admin0.40.40.7-0.3-0.5-0.6-0.4-0.8-0.8-0.4-0.8
Time to tail flick, vehicle, after self-admin1.01.32.0-0.8-1.1-1.2-1.0-1.2-1.3-1.0-1.4
Time to tail flick, test, before self-admin0.20.20.4-0.1-0.2-0.4-0.2-0.7-0.6-0.3-0.6
Time to tail flick, test, after self-admin0.00.10.10.00.20.20.30.30.30.10.3
Delta time to tail flick, vehicle, before/after SA0.50.50.6-0.7-0.8-0.8-0.8-0.6-0.7-0.7-0.8
Delta time to tail flick, test, before/after SA0.10.10.2-0.2-0.10.1-0.00.50.4-0.10.5
Tibia length0.92.44.8-2.2-1.5-1.6-1.2-1.7-1.5-1.3-1.2
Ambulatory time before self-admin0.91.42.6-1.6-1.2-1.2-0.9-1.2-1.1-1.0-1.0
Ambulatory time after self-admin0.10.20.3-0.5-0.4-0.4-0.3-0.4-0.4-0.3-0.4
Bone: tissue strength0.90.91.20.90.91.01.11.01.01.00.9
Total heroin consumption3.84.47.4-2.7-2.2-2.2-2.3-1.9-1.7-2.3-1.3
Bone: trabecular number0.91.51.9-1.2-1.1-1.2-1.1-1.4-1.3-1.0-1.2
Bone: trabecular spacing0.50.71.50.70.60.80.51.21.10.60.8
Bone: trabecular thickness0.20.30.40.50.60.50.60.30.40.60.4
Bone: trabecular tissue density4.46.47.12.72.62.62.42.62.52.42.4
Water consumed over 24 hours0.20.20.7-0.8-0.3-0.5-0.4-0.5-0.4-0.2-0.1
Number of responses in last shaping day0.50.50.8-0.8-0.7-0.7-0.9-0.6-0.6-0.8-0.5