LOC134483967

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	gene expression	LOC134483967	0.26	0.12	1.6e-05	0.07	0.16	0.14	0.13	1.1e-02	1.4e-04	3.9e-04	4.7e-04
2	NAcc	gene expression	LOC134483967	0.03	0.02	1.2e-05	0.04	0.04	0.04	0.04	4.4e-06	3.9e-06	3.3e-06	4.3e-06
3	IL	gene expression	LOC134483967	0.18	0.11	1.9e-03	0.12	0.11	0.1	0.1	1.0e-03	1.5e-03	2.8e-03	2.2e-03
4	Brain	gene expression	LOC134483967	0.12	0.06	8.9e-13	0.14	0.14	0.13	0.14	4.9e-13	1.0e-12	2.9e-12	1.4e-12
5	BLA	gene expression	LOC134483967	0.1	0.06	2.5e-05	0.05	0.08	0.06	0.07	9.5e-04	5.3e-05	2.6e-04	1.0e-04
6	pVTA	gene expression	LOC134483967	0.03	0.02	3.4e-03	0.01	0.02	0.01	0.02	7.3e-02	6.7e-03	2.4e-02	1.4e-02
7	Adipose	gene expression	LOC134483967	0.06	0.04	1.5e-06	0.04	0.05	0.04	0.04	9.6e-06	4.9e-06	2.5e-05	1.1e-05
8	LHb	gene expression	LOC134483967	0.16	0.09	1.9e-03	0.1	0.08	0.08	0.08	2.2e-03	6.0e-03	7.4e-03	5.1e-03
9	PL	gene expression	LOC134483967	0.1	0.06	2.6e-11	0.08	0.09	0.1	0.1	2.0e-09	7.1e-10	4.7e-11	5.4e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.5	0.9	1.3	-1.0	1.1	0.7	0.8	-1.1	-0.9	-1.1	0.7	0.8
Area under the delay curve	0.1	0.1	0.5	0.0	0.2	0.1	0.1	-0.2	-0.2	-0.3	0.4	0.7
BMI with tail	3.0	10.5	14.3	-3.0	3.8	2.8	2.8	-3.6	-3.2	-3.6	2.6	3.6
BMI without tail	0.3	1.7	3.1	-0.8	1.5	1.1	1.0	-1.3	-1.3	-1.5	1.4	1.8
Body weight	3.6	15.8	19.9	-3.7	4.5	3.8	3.8	-4.1	-4.1	-4.3	3.8	3.6
Weight adjusted by age	0.4	1.1	1.6	-1.3	1.3	1.1	1.1	-1.2	-1.1	-1.1	0.7	0.5
Bone surface	2.5	4.9	6.9	-2.6	2.6	2.1	2.2	-2.6	-2.2	-2.4	1.7	0.9
Bone volume	1.2	2.3	3.9	-2.0	1.8	1.3	1.4	-1.9	-1.5	-1.7	1.0	0.4
Breakpoint value in progressive ratio session	1.2	2.1	3.0	-1.7	1.4	1.7	1.7	-1.4	-1.6	-1.4	1.4	0.3
Number of licking bursts	0.0	0.1	0.3	-0.1	0.3	0.2	-0.0	-0.0	-0.0	-0.1	0.4	-0.5
Context. condit. distance diff. score	0.2	0.3	0.7	0.8	-0.6	-0.8	-0.7	0.5	0.5	0.4	-0.0	0.0
Locomotion velocity, session 1	0.1	0.1	0.7	0.6	-0.3	-0.1	-0.1	0.2	-0.0	-0.0	0.4	0.8
Locomotion distance, session 1	0.5	0.7	1.6	-0.4	0.6	0.6	0.6	-0.7	-0.9	-0.9	1.2	1.2
Locomotion velocity, session 2	2.5	2.9	3.4	-1.7	1.7	1.7	1.6	-1.8	-1.8	-1.8	1.8	1.5
Locomotion distance, session 2	0.1	0.2	0.9	-0.1	0.2	0.3	0.3	-0.3	-0.5	-0.5	0.9	0.4
Locomotion velocity, session 3	0.5	0.5	0.9	-0.5	0.9	0.5	0.3	-0.9	-0.7	-0.9	0.9	0.7
Locomotion distance, session 3	0.1	0.1	0.3	0.1	0.2	0.2	0.2	-0.1	-0.2	-0.2	0.4	0.5
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	0.1	0.1	-0.6	-0.5	-0.2	0.2	-0.1	0.2	-0.3
Stereotopy head waving duration, day 3	0.1	0.1	0.5	0.2	-0.1	-0.5	-0.5	-0.0	0.2	0.0	0.4	-0.7
Locomotion velocity, session 7	0.0	0.0	0.1	-0.2	0.1	-0.2	-0.2	-0.3	-0.1	-0.2	0.4	-0.1
Locomotion distance, session 7	0.1	0.1	0.4	0.5	-0.1	-0.4	-0.4	0.2	0.1	0.0	0.2	0.7
Stereotopy head waving bouts, day 7	0.3	0.3	0.7	-0.9	0.6	0.4	0.4	-0.8	-0.5	-0.6	0.5	-0.3
Stereotopy head waving duration, day 7	1.6	2.0	2.5	-1.6	1.5	1.4	1.4	-1.6	-1.4	-1.5	1.4	0.4
Locomotion velocity, session 8	0.2	0.2	0.6	0.8	-0.6	-0.4	-0.3	0.6	0.2	0.3	0.4	-0.1
Locomotion distance, session 8	0.2	0.2	0.7	0.5	-0.4	-0.8	-0.8	0.3	0.5	0.3	0.0	-0.1
Degree of sensitization distance	0.1	0.1	0.4	-0.1	0.4	-0.3	-0.2	-0.4	-0.1	-0.3	0.1	0.6
Degree of sensitization stereotypy	1.1	1.2	2.2	-1.5	1.2	1.1	1.0	-1.3	-1.0	-1.1	0.8	0.2
Conditioned locomotion	0.6	0.7	0.8	-0.7	0.8	0.8	0.9	-0.7	-0.8	-0.8	0.9	0.8
Cocaine response after cond. corrected	0.5	0.8	1.7	1.3	-1.1	-1.1	-0.7	1.0	0.8	0.7	-0.1	0.2
Cocaine response after cond. not corrected	0.3	0.5	1.0	1.0	-0.8	-0.8	-0.6	0.7	0.6	0.6	-0.4	0.3
Cocaine response before conditioning	0.4	0.5	1.1	-1.0	0.8	0.9	0.7	-0.8	-0.6	-0.6	-0.4	-0.2
Saline control response	2.4	3.3	5.0	-1.4	1.9	2.0	1.9	-1.6	-2.0	-1.9	2.2	1.5
Bone: connectivity density	2.1	3.3	4.2	-1.8	2.0	1.7	1.8	-2.0	-1.9	-2.0	1.5	1.3
Bone: cortical apparent density	0.1	0.2	0.7	-0.4	0.0	0.5	0.7	-0.2	-0.5	-0.3	0.9	-0.1
Bone: cortical area	1.0	1.6	2.4	-1.5	1.5	1.3	1.2	-1.5	-1.2	-1.3	0.9	0.8
Bone: cortical porosity	0.1	0.1	0.5	0.1	-0.5	-0.2	-0.1	0.3	0.2	0.4	0.1	-0.7
Bone: cortical porosity	0.0	0.1	0.2	0.0	-0.3	0.1	0.1	0.2	-0.0	0.1	0.4	-0.4
Bone: cortical thickness	2.4	4.0	5.8	-1.6	1.8	2.4	2.3	-1.6	-2.2	-1.9	2.3	1.6
Bone: cortical thickness	0.3	0.4	1.2	0.0	0.2	0.7	0.7	-0.1	-0.6	-0.4	0.8	1.1
Bone: cortical tissue density	0.2	0.3	1.1	-0.5	0.1	0.6	0.8	-0.4	-0.6	-0.4	1.0	0.0
Condit. Reinf. active minus inactive responses	1.1	1.2	1.5	-1.1	1.1	1.2	1.2	-1.1	-1.2	-1.2	0.9	0.9
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.7	-0.5	0.4	0.8	0.8	-0.5	-0.7	-0.6	0.7	0.4
Condit. Reinf. active responses	1.1	1.4	2.2	-1.5	1.3	1.2	1.1	-1.4	-1.2	-1.3	0.6	0.8
Condit. Reinf. inactive responses	0.1	0.2	0.5	-0.7	0.5	0.1	-0.1	-0.7	-0.1	-0.3	-0.6	0.1
Incentive salience index mean	1.4	1.8	2.3	-1.3	1.5	1.4	1.3	-1.5	-1.4	-1.5	1.1	1.2
Condit. Reinf. lever presses	1.1	1.6	2.5	-1.3	1.6	1.2	1.1	-1.5	-1.3	-1.4	1.0	1.0
Condit. Reinf. active minus inactive responses	0.1	0.2	0.9	-0.2	-0.2	-0.3	-0.3	0.1	0.4	0.4	-0.5	-1.0
Condit. Reinf. active-inactive response ratio	0.4	0.6	2.5	-0.4	-0.2	-0.7	-0.7	-0.1	0.6	0.4	-0.9	-1.6
Condit. Reinf. active responses	0.1	0.1	0.2	-0.4	0.3	0.3	0.3	-0.3	-0.3	-0.2	0.3	-0.1
Condit. Reinf. inactive responses	0.2	0.3	1.3	0.3	0.1	0.5	0.6	0.1	-0.4	-0.3	0.7	1.1
Condit. Reinf. lever presses	1.0	1.5	2.2	-1.5	1.5	1.3	1.3	-1.4	-1.2	-1.3	0.7	0.5
Condit. Reinf. lever reinforcers received	0.2	0.3	0.4	-0.7	0.5	0.5	0.6	-0.5	-0.5	-0.4	0.5	-0.0
Conditioned reinforcement - actives	0.1	0.4	1.3	-0.4	-0.3	-0.4	-0.6	-0.1	0.5	0.4	-1.1	-1.1
Conditioned reinforcement - inactives	0.1	0.2	0.7	-0.8	0.3	-0.1	-0.2	-0.7	0.1	-0.2	-0.7	-0.3
Conditioned locomotion	1.3	2.0	3.0	1.1	-1.3	-1.7	-1.7	1.0	1.6	1.3	-1.7	-0.8
Patch foraging indifference point 0 sec	0.3	0.9	1.5	-0.8	0.9	0.9	0.9	-0.9	-1.0	-1.0	1.2	0.6
Patch foraging indifference point AUC	0.8	1.8	3.7	-1.9	1.3	1.4	1.5	-1.5	-1.3	-1.3	0.9	0.1
Delay disc. indifference point, 0s delay	0.3	0.3	0.6	0.7	-0.3	-0.7	-0.7	0.4	0.5	0.3	-0.3	0.6
Delay disc. indifference point, 16s delay	0.1	0.2	0.4	-0.6	0.6	0.3	0.3	-0.6	-0.4	-0.5	0.2	0.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	0.2	-0.2	-0.6	-0.5	0.1	0.4	0.2	-0.6	0.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.5	0.1	0.2	0.3	0.3	-0.1	-0.3	-0.3	0.5	0.7
Delay disc. indifference point, 4s delay	0.4	0.4	1.4	0.0	0.5	0.4	0.4	-0.4	-0.6	-0.6	1.0	1.2
Delay disc. indifference point, 8s delay	0.3	0.4	1.0	1.0	-0.8	-0.6	-0.7	0.8	0.6	0.6	-0.1	-0.1
Indifference point function ln k	1.6	4.7	9.5	3.1	-2.3	-2.4	-2.2	2.5	2.2	2.0	-1.5	-0.1
Indifference point function log k	1.6	4.7	9.5	3.1	-2.3	-2.4	-2.2	2.5	2.2	2.0	-1.5	-0.1
Patch foraging total patch changes 0 sec	0.3	0.8	1.7	-0.5	0.8	1.0	0.9	-0.7	-0.9	-0.9	1.3	0.8
Patch foraging total patch changes 12 sec	5.6	7.5	8.8	-2.9	2.6	2.9	3.0	-2.7	-2.9	-2.7	2.9	1.8
Patch foraging total patch changes 18 sec	0.3	0.7	1.1	-1.1	0.7	0.9	1.0	-0.9	-0.9	-0.8	0.9	-0.1
Patch foraging total patch changes 24 sec	2.5	8.5	10.0	-2.8	3.0	3.0	3.2	-2.9	-3.1	-3.0	3.2	2.0
Patch foraging total patch changes 6 sec	1.2	2.0	2.9	-1.2	1.4	1.4	1.5	-1.3	-1.5	-1.4	1.7	1.3
Patch foraging time to switch 0 sec	0.2	0.7	1.6	-1.2	1.1	0.6	0.5	-1.2	-0.8	-1.0	0.3	0.2
Patch foraging water rate 0 sec	0.2	0.8	1.6	1.3	-1.1	-0.8	-0.7	1.2	0.9	1.0	-0.5	-0.3
Patch foraging water rate 12 sec	0.8	3.3	6.8	2.6	-1.9	-1.7	-1.7	2.3	1.8	1.9	-1.2	-0.1
Patch foraging water rate 18 sec	0.4	0.9	2.9	1.7	-0.7	-0.8	-0.8	1.2	0.7	0.7	-0.2	0.7
Patch foraging water rate 24 sec	1.4	2.0	3.5	1.9	-1.6	-1.5	-1.4	1.7	1.4	1.4	-1.0	-0.5
Patch foraging water rate 6 sec	1.6	2.4	5.3	2.3	-1.7	-1.5	-1.5	2.0	1.5	1.6	-0.8	-0.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.5	-0.1	0.3	0.2	0.2	-0.2	-0.2	-0.3	0.2	0.7
Distance traveled before self-admin	1.5	3.2	4.8	-2.2	2.0	1.8	1.8	-2.1	-1.8	-1.9	1.4	0.8
Distance traveled after self-admin	0.3	0.5	0.8	-0.8	0.7	0.9	0.9	-0.6	-0.7	-0.6	0.6	0.1
Extensor digitorum longus weight	6.4	25.7	29.5	-4.7	5.4	5.4	5.2	-5.0	-5.3	-5.3	5.2	3.8
Bone: elastic displacement	0.5	0.7	1.3	1.2	-1.0	-0.7	-0.6	1.1	0.7	0.9	-0.4	-0.1
Bone: elastic work	0.7	1.0	2.1	-0.3	0.8	1.0	1.1	-0.5	-1.1	-0.9	1.2	1.5
Bone: endosteal estimation	0.4	0.9	2.6	0.4	-0.3	-1.4	-1.3	0.2	1.1	0.6	-1.6	-0.5
Bone: endosteal perimeter	0.7	1.7	4.3	0.3	-0.5	-1.7	-1.7	0.3	1.5	1.0	-2.1	-1.1
Epididymis fat weight	0.2	1.2	3.7	0.2	-0.3	-1.4	-1.3	0.3	1.2	0.8	-1.9	-1.0
Delta time in closed arm before/after self-admin	1.0	0.9	2.4	0.0	0.7	0.8	0.8	-0.4	-1.0	-0.9	1.5	1.5
Delta time in open arm before/after self-admin	1.9	2.3	4.4	-2.1	1.6	1.5	1.5	-1.8	-1.5	-1.5	1.0	0.1
Diff in mean of infusions in LGA sessions	1.4	2.5	3.8	-1.4	1.4	1.7	1.7	-1.4	-1.7	-1.6	2.0	1.1
Delay discount exponential model param	0.1	0.1	0.5	0.0	-0.3	-0.1	-0.1	0.3	0.3	0.4	-0.5	-0.7
Extinction: sum of active levers before priming	2.9	4.4	4.8	-2.1	2.1	2.2	2.2	-2.2	-2.2	-2.2	2.1	1.4
Active lever presses in extinction session 6	2.9	3.0	4.8	-2.2	1.7	1.8	1.8	-2.0	-1.8	-1.8	1.3	0.5
Bone: final force	1.8	3.0	4.1	-1.9	2.0	1.7	1.6	-2.0	-1.8	-1.9	1.4	1.1
Bone: final moment	1.9	3.1	4.2	-1.9	2.0	1.8	1.7	-2.0	-1.8	-1.9	1.5	1.1
Food consumed during 24 hour testing period	0.0	0.1	0.2	0.1	-0.0	-0.1	-0.2	0.2	0.3	0.3	-0.5	-0.4
Glucose	1.6	2.6	4.0	1.6	-1.4	-2.0	-1.9	1.4	1.8	1.6	-1.8	-0.4
Heart weight	0.2	0.3	1.1	0.8	-0.1	-0.6	-0.5	0.3	0.3	0.1	-0.3	1.0
Delay discount hyperbolic model param	0.1	0.1	0.4	-0.0	-0.2	-0.0	-0.0	0.2	0.2	0.3	-0.3	-0.6
Intermittent access intake day 1-15 change	0.4	2.2	3.9	0.6	-1.3	-1.5	-1.4	1.1	1.6	1.5	-1.9	-2.0
Intermittent access intake escalation	0.5	2.8	5.0	0.7	-1.5	-1.7	-1.6	1.2	1.8	1.7	-2.1	-2.2
Intermittent access intake escalation 2	0.5	0.8	2.3	-0.1	-0.6	-0.8	-0.8	0.3	0.9	0.8	-1.3	-1.5
Intermitt. access day 1 inactive lever presses	0.1	1.7	2.8	0.7	-1.3	-1.2	-1.4	1.0	1.3	1.3	-1.4	-1.7
Intermitt. access day 15 inactive lever presses	0.3	1.4	3.1	-1.8	1.5	0.9	0.8	-1.7	-0.9	-1.2	0.2	0.4
Intermitt. access escalation Index	0.3	0.9	1.6	1.3	-1.1	-1.0	-0.9	1.2	1.0	1.0	-0.7	-0.2
Intermittent access day 1 total infusions	0.1	0.3	0.8	-0.2	0.3	-0.6	-0.8	-0.5	0.4	-0.2	-0.9	0.6
Intermittent access day 15 total infusions	1.3	3.2	7.2	0.8	-1.4	-2.1	-2.2	1.0	2.0	1.6	-2.7	-1.5
Intermittent access terminal intake (last 3 days)	0.4	0.8	2.9	-0.3	-0.1	-1.1	-1.1	-0.3	0.9	0.4	-1.7	-0.6
Intermittent access total infusions	0.6	0.7	2.4	-0.0	-0.2	-1.1	-1.2	-0.1	0.9	0.4	-1.5	-0.3
Intermittent access day 1 locomotion	0.1	0.1	0.4	-0.3	0.4	-0.2	-0.3	-0.6	0.0	-0.4	-0.3	0.6
Intermittent access day 15 total locomotion	0.1	0.3	0.8	-0.8	0.3	-0.4	-0.4	-0.7	0.2	-0.2	-0.9	-0.3
Intermittent access total locomotion	0.4	0.5	1.3	-1.1	0.6	-0.4	-0.5	-1.1	0.1	-0.5	-1.0	0.1
Intermittent access standard deviation	0.2	1.1	2.2	0.5	-0.9	-1.1	-1.1	0.7	1.1	1.0	-1.5	-1.2
Left kidney weight	0.0	0.2	0.7	-0.1	0.1	-0.6	-0.6	-0.2	0.4	0.1	-0.8	0.1
Right kidney weight	0.0	0.1	0.3	-0.2	0.2	-0.4	-0.4	-0.2	0.3	0.1	-0.6	-0.2
Cocaine induced anxiety	0.0	0.1	0.3	-0.5	0.1	0.1	0.1	-0.3	-0.1	-0.1	-0.1	-0.6
Post-drug Anxiety	0.3	0.3	0.6	-0.8	0.6	0.6	0.6	-0.7	-0.6	-0.6	0.4	0.3
Baseline Anxiety	0.3	0.5	1.7	-0.1	0.6	0.6	0.6	-0.3	-0.7	-0.6	0.9	1.3
Tail length	0.1	0.7	2.1	-0.4	0.7	1.1	1.0	-0.4	-0.9	-0.7	1.5	0.3
Length with tail	1.2	5.3	7.8	-1.9	2.3	2.6	2.5	-2.0	-2.4	-2.3	2.8	1.6
Length without tail	1.7	9.1	12.0	-2.5	3.1	3.2	3.2	-2.7	-3.2	-3.0	3.5	2.7
Times rat made contact with spout	0.1	0.1	0.5	0.3	0.0	0.3	0.3	0.2	-0.2	-0.1	0.7	0.2
Lifetime Intake	0.4	0.5	1.6	0.3	-0.2	-1.0	-1.1	0.1	0.8	0.4	-1.3	0.1
Liver weight, left	1.0	1.8	2.2	1.4	-1.4	-1.3	-1.3	1.5	1.5	1.5	-1.3	-0.6
Liver weight, right	1.2	2.1	3.5	1.9	-1.4	-1.6	-1.6	1.6	1.5	1.4	-1.2	0.1
Locomotor activity	1.0	1.6	3.9	2.0	-1.4	-1.0	-1.1	1.7	1.2	1.3	-0.6	-0.2
Locomotor testing distance	0.7	1.8	4.5	2.1	-1.5	-1.2	-1.2	1.8	1.2	1.3	-0.7	0.0
Locomotor testing rearing	0.5	1.9	3.9	2.0	-1.5	-1.4	-1.3	1.7	1.3	1.4	-1.0	-0.1
Locomotion in novel chamber	1.4	1.9	3.5	0.9	-1.1	-1.6	-1.6	1.0	1.5	1.3	-1.9	-1.2
Locomotion in novel chamber post-restriction	0.9	2.8	4.3	1.1	-1.6	-1.9	-1.7	1.4	1.8	1.7	-1.6	-2.1
Fecal boli incidents, locomotor time 1	0.1	0.3	1.0	-0.3	-0.3	-0.4	-0.4	0.0	0.5	0.4	-0.9	-1.0
Change in fecal boli incidents, locomotor task	1.1	1.2	2.4	1.6	-1.1	-1.2	-1.2	1.3	1.1	1.0	-0.5	0.0
Time >=10cm from walls, locomotor time 1	1.1	1.4	3.0	0.3	-0.9	-1.2	-1.5	0.5	1.3	1.1	-1.7	-1.3
Bouts of movement, locomotor time 1	0.1	0.2	1.0	-0.3	-0.1	0.6	0.2	0.1	-0.2	0.1	0.2	-1.0
Total resting periods, locomotor time 1	0.1	0.2	0.9	-0.5	0.0	0.5	0.3	-0.1	-0.2	0.0	0.1	-0.9
Rest time, locomotor task time 1	1.3	2.1	2.5	1.2	-1.6	-1.5	-1.2	1.4	1.6	1.6	-1.5	-1.4
Distance moved, locomotor task time 1	0.2	0.5	0.9	-0.6	0.7	0.6	0.6	-0.7	-0.7	-0.8	0.5	0.9
Vertical activity count, locomotor time 1	0.1	0.4	0.7	0.7	-0.7	-0.7	-0.8	0.6	0.7	0.6	-0.6	-0.2
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.8	-0.4	-0.2	0.0	-0.1	-0.1	0.2	0.2	-0.6	-0.9
Bouts of movement, locomotor time 2	0.4	1.2	1.6	-1.1	1.1	1.3	1.3	-1.0	-1.2	-1.1	1.0	0.6
Total resting periods, locomotor time 2	0.1	0.5	0.8	-0.8	0.8	0.8	0.9	-0.7	-0.8	-0.7	0.6	0.3
Rest time, locomotor task time 2	2.1	3.6	4.3	1.8	-2.0	-2.1	-2.0	1.9	2.1	2.0	-1.7	-1.5
Distance moved, locomotor task time 2	0.3	0.4	0.8	-0.6	0.5	0.9	0.9	-0.5	-0.7	-0.6	0.5	0.3
Vertical activity count, locomotor time 2	0.1	0.1	0.4	0.6	-0.5	-0.0	-0.1	0.6	0.2	0.4	0.1	-0.0
Light reinforcement 1	0.0	0.1	0.2	0.3	-0.3	-0.1	-0.1	0.4	0.3	0.3	-0.3	-0.5
Light reinforcement 2	0.2	0.4	1.4	-0.8	0.3	-0.3	-0.3	-0.5	0.3	0.0	-1.0	-1.2
Bone: marrow area	0.5	1.2	2.9	0.6	-0.4	-1.6	-1.5	0.4	1.2	0.8	-1.7	-0.5
Bone: maximum diameter	0.3	0.5	1.5	-1.2	1.0	0.5	0.5	-1.1	-0.5	-0.7	0.1	-0.2
Bone: maximum force	2.8	5.6	8.2	-2.7	2.9	2.2	2.2	-2.8	-2.3	-2.6	1.6	1.5
Bone: maximum moment	2.9	5.5	8.1	-2.7	2.8	2.2	2.2	-2.8	-2.3	-2.6	1.6	1.5
Mean time between licks in bursts	0.1	0.6	2.7	0.4	0.4	0.7	0.6	-0.0	-0.6	-0.5	0.8	1.7
Mean num. licks in bursts	0.1	0.1	0.3	0.5	-0.6	-0.3	-0.1	0.5	0.3	0.4	-0.2	0.3
Cd content in liver	0.7	0.8	1.9	0.4	-0.9	-0.9	-0.9	0.5	0.9	0.8	-0.8	-1.4
Co content in liver	1.3	1.6	3.0	1.7	-1.7	-1.0	-1.0	1.7	1.1	1.4	-0.5	-0.4
Cu content in liver	0.1	0.1	0.2	0.3	-0.3	-0.1	-0.1	0.3	0.1	0.2	0.0	-0.5
Fe content in liver	0.1	0.1	0.5	0.2	-0.2	-0.2	-0.1	0.1	0.1	0.1	0.0	-0.7
K content in liver	0.6	0.5	1.0	-0.6	0.9	0.6	0.5	-0.7	-0.7	-0.8	0.6	1.0
Mg content in liver	0.1	0.1	0.5	0.1	0.3	0.0	0.0	-0.1	-0.2	-0.3	0.5	0.7
Mn content in liver	3.4	3.8	4.7	-2.2	2.2	2.1	2.0	-2.1	-2.0	-2.0	1.8	0.9
Na content in liver	0.5	0.5	0.8	-0.8	0.9	0.6	0.7	-0.8	-0.7	-0.8	0.5	0.7
Rb content in liver	2.8	3.2	4.5	2.1	-1.8	-1.9	-2.0	2.0	1.8	1.8	-1.4	-1.0
Se content in liver	0.3	0.3	0.8	-0.9	0.6	0.3	0.3	-0.7	-0.3	-0.4	-0.0	-0.9
Sr content in liver	4.1	3.5	4.2	-2.0	1.8	2.0	2.0	-1.9	-2.0	-1.9	2.1	0.9
Zn content in liver	2.7	3.1	4.3	-1.7	1.7	1.8	1.8	-1.8	-1.9	-1.8	2.1	1.4
Bone: minimum diameter	0.2	0.4	1.4	-0.1	0.2	-0.8	-0.9	-0.2	0.6	0.2	-1.2	0.0
Time in familiar zone, hab. session 1	0.2	0.2	0.8	-0.2	0.4	0.3	0.4	-0.4	-0.3	-0.4	0.1	0.9
Time in novel zone, hab. session 1	1.4	1.6	2.2	1.5	-1.4	-1.3	-1.3	1.5	1.3	1.3	-1.0	-0.7
Total zone transitions, hab. session 1	0.2	0.3	1.0	-0.4	0.3	0.5	0.4	-0.4	-0.5	-0.5	1.0	0.6
Total locomotion distance, hab. session 1	0.0	0.0	0.1	-0.2	0.1	-0.3	-0.3	-0.2	0.1	-0.0	0.1	0.3
Locomotion velocity, hab. session 1	0.2	0.3	0.5	-0.7	0.5	0.3	0.2	-0.7	-0.4	-0.5	0.7	0.5
Time in familiar zone, hab. session 2	0.5	0.5	1.2	1.1	-0.7	-0.4	-0.3	1.0	0.6	0.8	-0.7	0.4
Time in novel zone, hab. session 2	0.6	0.6	1.0	-0.9	0.9	0.6	0.6	-1.0	-0.8	-0.9	0.8	0.2
Total zone transitions, hab. session 2	1.5	1.9	3.7	-0.9	1.3	1.3	1.2	-1.2	-1.4	-1.4	1.6	1.9
Total locomotion distance, hab. session 2	0.3	0.4	1.4	-0.3	0.5	0.3	0.2	-0.5	-0.5	-0.6	0.7	1.2
Locomotion velocity, hab. session 2	0.2	0.2	0.9	-0.3	0.4	0.1	0.0	-0.5	-0.3	-0.5	0.5	0.9
Novel to familiar place preference ratio	1.8	2.3	3.5	-1.9	1.7	1.6	1.4	-1.8	-1.6	-1.6	1.2	0.4
Novelty place preference	1.1	1.4	2.4	-1.5	1.3	1.3	1.1	-1.4	-1.2	-1.3	0.9	0.1
Time in novel zone, NPP test	1.2	1.5	2.3	-1.5	1.4	1.3	1.1	-1.4	-1.3	-1.3	0.9	0.3
Total zone transitions, NPP test	0.9	1.4	2.9	-0.9	1.0	1.1	1.1	-1.1	-1.3	-1.3	1.7	1.1
Total locomotion distance, NPP test	0.1	0.1	0.4	-0.0	0.1	0.0	-0.0	-0.3	-0.3	-0.3	0.7	0.4
Locomotion velocity, NPP test	0.0	0.0	0.3	0.0	-0.1	-0.1	-0.1	-0.1	-0.2	-0.2	0.6	0.1
Intraocular pressure	0.2	0.4	2.0	0.3	-0.5	-0.3	-0.3	0.5	0.5	0.6	-0.5	-1.4
Delta distance traveled before/after self-admin	0.7	0.7	1.8	1.3	-1.0	-0.6	-0.6	1.2	0.7	0.9	-0.3	0.1
Delta ambulatory time before/after self-admin	0.7	1.2	2.5	1.6	-1.3	-0.9	-0.9	1.5	1.0	1.2	-0.5	-0.2
Parametrial fat weight	0.8	1.9	4.4	0.6	-0.9	-1.7	-1.7	0.7	1.7	1.2	-2.1	-1.0
Pavlov. Cond. lever latency	1.2	1.5	2.2	1.3	-1.5	-1.2	-1.1	1.4	1.2	1.3	-0.9	-1.1
Pavlov. Cond. magazine entry latency	1.5	2.0	3.1	-1.7	1.7	1.3	1.3	-1.7	-1.3	-1.4	0.5	1.3
Pavlov. Cond. change in total contacts	0.7	0.7	1.9	-1.4	1.0	0.7	0.7	-1.2	-0.7	-0.8	0.2	0.2
Pavlov. Cond. index score	0.9	1.2	1.8	-1.3	1.3	1.1	1.1	-1.3	-1.0	-1.1	0.5	0.8
Pavlov. Cond. latency score	0.8	1.0	1.5	-1.2	1.2	1.0	1.0	-1.2	-1.0	-1.1	0.5	1.0
Pavlov. Cond. lever contacts	0.7	0.8	1.3	-0.9	1.1	0.8	0.8	-1.0	-0.8	-1.0	0.5	1.1
Pavlov. Cond. magazine entry number	0.9	1.2	2.1	1.5	-1.2	-1.2	-1.2	1.3	1.1	1.1	-0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.2	1.0	-0.5	-0.1	0.2	0.1	-0.2	-0.1	0.0	-0.3	-1.0
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	2.2	-1.5	1.3	1.1	1.1	-1.4	-1.1	-1.1	0.5	0.8
Pavlov. Cond. response bias	1.2	1.5	2.4	-1.6	1.4	1.2	1.2	-1.4	-1.2	-1.2	0.6	0.8
Pavlov. Cond. lever latency	0.6	0.9	1.4	1.1	-1.2	-1.0	-1.1	1.1	0.9	1.0	-0.4	-0.5
Pavlov. Cond. magazine entry latency	4.4	6.2	7.5	-2.7	2.6	2.7	2.7	-2.6	-2.6	-2.6	1.9	1.8
Pavlov. Cond. change in total contacts	1.0	2.5	4.2	-2.0	1.8	1.6	1.8	-1.8	-1.5	-1.6	0.7	0.8
Pavlov. Cond. index score	2.6	4.1	5.7	-2.4	2.3	2.1	2.2	-2.3	-2.1	-2.1	1.1	1.2
Pavlov. Cond. latency score	2.3	3.8	5.6	-2.4	2.2	2.0	2.1	-2.2	-2.0	-2.0	1.1	1.0
Pavlov. Cond. lever contacts	0.5	0.8	1.1	-1.0	1.0	0.9	1.0	-1.0	-0.8	-0.9	0.2	0.5
Pavlov. Cond. magazine entry number	7.4	9.6	11.8	3.4	-3.2	-3.3	-3.4	3.3	3.3	3.2	-2.4	-2.0
Pavlov. Cond. intertrial magazine entries	1.1	2.4	3.3	1.3	-1.6	-1.6	-1.5	1.5	1.6	1.6	-1.2	-1.8
Pavlov. Cond. lever-magazine prob. diff.	3.0	4.6	6.3	-2.5	2.4	2.2	2.4	-2.4	-2.2	-2.2	1.2	1.3
Pavlov. Cond. response bias	2.2	3.1	3.9	-1.9	2.0	1.9	2.0	-1.9	-1.8	-1.8	1.1	1.4
Time in closed arm before self-admin	0.1	0.1	0.4	-0.5	0.2	-0.1	-0.1	-0.3	0.2	0.0	-0.6	-0.4
Time in closed arm after self-admin	0.8	0.9	1.4	1.2	-0.9	-1.0	-1.0	1.1	1.0	1.0	-0.9	-0.2
Time in open arm before self-admin	1.4	1.7	4.8	2.2	-1.4	-1.1	-1.1	1.7	1.0	1.2	-0.1	0.4
Time in open arm after self-admin	0.3	0.4	1.1	-0.3	0.4	0.7	0.7	-0.4	-0.7	-0.6	1.1	0.3
Bone: periosteal estimation	0.1	0.3	0.9	-0.9	0.9	0.0	0.0	-1.0	-0.2	-0.6	-0.4	0.2
Bone: periosteal perimeter	0.1	0.2	0.7	-0.9	0.7	0.1	0.1	-0.8	-0.1	-0.4	-0.3	-0.0
Bone: post-yield work	0.3	0.5	1.4	-1.1	0.9	-0.1	0.0	-1.2	-0.1	-0.6	-0.7	-0.0
Progressive ratio test 1 active lever presses	0.2	0.3	0.6	0.2	-0.5	-0.6	-0.8	0.2	0.6	0.4	-0.8	-0.4
Progressive ratio test 1 breakpoint	0.2	0.3	0.7	0.2	-0.5	-0.6	-0.8	0.2	0.6	0.4	-0.8	-0.4
Progressive ratio test 1 inactive lever presses	0.3	0.8	1.3	-1.1	1.1	0.9	0.7	-1.1	-0.9	-1.0	0.6	0.7
Progressive ratio test 2 active lever presses	0.5	0.7	2.1	-0.1	-0.5	-0.9	-1.0	0.1	0.9	0.5	-1.4	-0.8
Progressive ratio test 2 breakpoint	0.5	0.6	1.9	-0.1	-0.4	-0.9	-0.9	-0.0	0.8	0.5	-1.4	-0.8
Progressive ratio test 2 inactive lever presses	0.1	0.4	1.7	-0.4	-0.1	-0.7	-0.8	-0.2	0.6	0.3	-1.3	-0.6
Incentive Sensitization - Responses	0.4	1.2	2.4	-1.5	1.3	0.8	0.9	-1.5	-0.9	-1.2	0.3	0.5
Incentive Sensitization - Breakpoint	0.4	0.9	2.1	-1.4	1.2	0.7	0.8	-1.4	-0.8	-1.0	0.2	0.4
Sum of active levers in priming session hrs 5-6	1.1	1.0	2.9	-1.7	0.8	1.1	1.1	-1.1	-0.9	-0.7	0.3	-0.8
Progressive ratio	0.1	0.2	0.5	-0.5	0.7	0.1	0.0	-0.6	-0.1	-0.3	-0.3	0.2
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.4	-0.1	-0.2	-0.3	0.3	0.2	0.2	-0.0	0.4
Seeking ratio, punishment vs. effort	0.1	0.3	0.8	0.9	-0.7	-0.3	-0.2	0.7	0.2	0.3	0.4	0.5
Retroperitoneal fat weight	2.9	12.9	17.6	3.4	-3.2	-4.2	-4.2	3.2	4.0	3.6	-4.0	-2.2
Reaction time number correct	0.1	0.4	0.9	-0.3	0.7	0.9	0.9	-0.4	-0.7	-0.7	0.7	0.4
Reaction time mean minus median	0.1	0.7	2.2	-1.5	0.7	0.8	0.9	-1.0	-0.6	-0.6	0.2	-0.4
Reaction time mean minus median AUC	0.0	0.1	0.4	-0.6	0.0	0.4	0.5	-0.2	-0.2	-0.0	-0.0	-0.5
Reaction time num false alarms	0.4	0.7	2.2	1.5	-1.2	-0.7	-0.5	1.2	0.6	0.8	-0.0	0.4
Reaction time num false alarms AUC	0.2	0.4	1.2	1.1	-0.8	-0.1	0.1	0.8	0.1	0.3	0.6	0.5
Reaction time trials correct on left	0.1	0.4	0.9	-0.3	0.7	0.9	0.9	-0.4	-0.7	-0.7	0.7	0.4
Reaction time trials on left	0.1	0.5	0.9	-0.3	0.7	0.9	0.9	-0.4	-0.8	-0.7	0.7	0.4
Reaction time mean	0.0	0.1	0.3	-0.4	-0.3	-0.2	0.1	-0.1	0.2	0.2	-0.6	-0.4
Reaction time mean AUC	0.1	0.2	0.6	-0.3	-0.3	-0.2	-0.1	0.1	0.3	0.4	-0.8	-0.5
Median of all reaction times	0.0	0.0	0.2	-0.3	-0.2	-0.2	0.1	-0.1	0.1	0.1	-0.4	-0.1
Reaction time omissions	0.1	0.2	0.6	-0.6	0.2	0.5	0.8	-0.4	-0.5	-0.3	0.5	0.1
Reaction time false alarm rate	0.4	0.5	1.3	1.1	-1.0	-0.7	-0.5	0.9	0.5	0.6	0.0	0.3
Reaction time premature initiation rate	3.9	6.0	8.2	-1.6	2.6	2.5	2.5	-2.1	-2.6	-2.5	2.7	2.9
Reaction time premature initiations	2.2	6.8	8.7	-1.6	2.7	2.9	2.9	-2.1	-2.8	-2.7	2.9	2.7
Std. dev. reaction times	0.1	0.2	1.0	-0.4	-0.5	-0.2	0.1	0.1	0.3	0.4	-0.5	-1.0
Reaction time trials completed	0.1	0.5	0.9	-0.3	0.7	0.9	0.9	-0.4	-0.8	-0.7	0.7	0.4
Reaction time trials AUC	0.1	0.4	0.7	-0.2	0.6	0.8	0.8	-0.3	-0.7	-0.6	0.6	0.5
Run reversals in cocaine runway, females	0.7	0.8	3.1	0.0	0.8	0.6	0.5	-0.5	-0.7	-0.9	1.1	1.8
Run reversals in cocaine runway, males	0.5	0.6	0.8	0.8	-0.9	-0.7	-0.8	0.9	0.8	0.8	-0.3	-0.6
Latency to leave start box in cocaine runway	0.2	0.2	0.6	0.3	-0.3	-0.6	-0.6	0.2	0.6	0.4	-0.8	-0.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.2	0.3	0.2	0.2	-0.3	-0.2	-0.3	0.1	0.4
Latency to leave start box in cocaine runway, M	1.8	1.7	2.3	1.2	-1.2	-1.5	-1.5	1.1	1.4	1.3	-1.5	-0.9
Std. dev. time between licks in bursts	0.2	0.4	1.1	1.0	-0.4	-0.2	-0.3	0.7	0.3	0.3	-0.1	1.0
Total sessions with >9 infusions	0.5	0.7	1.1	0.7	-0.6	-1.0	-1.0	0.6	0.9	0.7	-1.1	-0.3
Short access day 1 total inactive lever presses	0.0	0.1	0.3	0.0	0.1	-0.1	-0.1	-0.2	0.0	-0.2	-0.1	0.6
Short access day 10 total inactive lever presses	0.1	0.7	0.9	0.9	-1.0	-0.8	-0.8	1.0	0.9	0.9	-0.7	-0.7
Short access day 1 total infusions	0.6	1.2	1.8	1.1	-0.9	-1.4	-1.3	0.9	1.2	1.0	-1.3	-0.2
Short access day 10 total infusions	0.1	0.2	0.5	-0.1	0.2	-0.5	-0.6	-0.3	0.3	-0.1	-0.7	0.5
Short access total infusions	0.3	0.4	0.9	0.7	-0.3	-0.9	-1.0	0.3	0.7	0.4	-0.8	0.5
Short access day 1 locomotion	0.1	0.2	0.4	0.1	-0.2	-0.6	-0.6	0.1	0.4	0.2	-0.7	-0.2
Short access day 10 total locomotion	0.1	0.3	0.8	-0.8	0.7	0.1	0.1	-0.9	-0.3	-0.6	0.0	0.4
Short access total locomotion	0.1	0.1	0.2	-0.3	0.2	-0.3	-0.4	-0.4	0.2	-0.1	-0.5	0.1
One hour access (0.3 mA shock)	0.6	0.7	1.8	0.2	-0.4	-1.2	-1.1	0.2	1.0	0.6	-1.4	-0.5
Compulsive drug intake	0.4	0.6	1.7	0.1	0.5	0.9	1.1	-0.0	-0.8	-0.5	1.3	0.7
One hour access (shock baseline)	1.1	2.9	6.0	0.6	-1.3	-2.1	-2.2	0.8	1.9	1.5	-2.5	-1.5
Social response proportion	0.0	0.0	0.1	0.0	0.3	0.2	0.1	-0.0	-0.1	-0.1	-0.0	0.2
Social responses	0.0	0.0	0.1	0.3	-0.0	0.2	0.2	0.3	-0.1	0.1	0.2	-0.1
Social time	0.1	0.1	0.4	0.6	-0.4	-0.2	-0.1	0.6	0.2	0.4	0.3	-0.2
Soleus weight	2.8	8.4	10.0	3.0	-3.0	-3.0	-3.2	3.0	3.1	3.0	-2.8	-1.9
Bone: stiffness	0.8	1.5	2.9	-1.7	1.5	1.2	1.0	-1.5	-1.1	-1.2	0.5	0.4
Tibialis anterior weight	8.6	29.6	34.1	-5.4	5.5	5.8	5.8	-5.4	-5.8	-5.6	5.8	3.3
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.7	-0.8	0.7	0.3	0.4	-0.9	-0.5	-0.7	0.2	0.4
Time to tail flick, vehicle, after self-admin	0.2	0.5	1.3	-0.4	0.8	0.5	0.5	-0.6	-0.6	-0.7	0.7	1.1
Time to tail flick, test, before self-admin	0.6	0.6	1.8	-0.3	0.9	0.5	0.5	-0.8	-0.7	-0.9	0.9	1.3
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.5	0.3	0.2	0.2	-0.3	-0.1	-0.2	-0.1	-0.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	-0.1	0.4	0.4	0.3	-0.2	-0.4	-0.4	0.7	0.7
Delta time to tail flick, test, before/after SA	0.2	0.3	1.9	-0.3	-0.3	0.1	0.1	0.2	0.2	0.4	-0.5	-1.4
Tibia length	1.7	4.6	9.0	-3.0	2.3	2.2	2.0	-2.7	-2.1	-2.2	1.7	0.1
Ambulatory time before self-admin	0.9	2.7	4.7	-2.2	1.9	1.6	1.6	-2.0	-1.6	-1.7	1.1	0.5
Ambulatory time after self-admin	0.2	0.2	0.5	-0.7	0.6	0.6	0.5	-0.6	-0.4	-0.4	0.2	0.1
Bone: tissue strength	0.4	0.4	0.7	0.8	-0.4	-0.5	-0.6	0.8	0.6	0.6	-0.6	-0.8
Total heroin consumption	4.8	5.7	7.4	-2.4	2.2	2.7	2.7	-2.2	-2.6	-2.4	2.7	1.0
Bone: trabecular number	1.1	2.1	3.1	-1.6	1.8	1.4	1.4	-1.8	-1.5	-1.7	1.2	0.5
Bone: trabecular spacing	0.8	1.1	2.0	1.4	-1.2	-0.9	-0.9	1.4	1.0	1.2	-0.8	-0.4
Bone: trabecular thickness	0.1	0.1	0.4	-0.1	-0.2	-0.3	-0.3	-0.0	0.3	0.2	-0.6	0.0
Bone: trabecular tissue density	4.9	8.5	10.7	2.8	-3.3	-3.0	-2.9	3.0	3.0	3.1	-2.5	-2.8
Water consumed over 24 hours	0.3	0.6	1.0	-0.4	0.8	1.0	0.9	-0.4	-0.8	-0.7	1.0	0.6
Number of responses in last shaping day	0.1	0.1	0.3	0.1	0.2	0.3	0.3	-0.1	-0.4	-0.3	0.6	0.5