Hub : Genes

LOC134483845

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression LOC134483845 0.51 0.12 0.0e+00 0.55 0.54 0.56 0.56 1.3e-73 8.7e-72 2.9e-74 1.4e-75
2 LHb gene expression LOC134483845 0.37 0.15 1.1e-07 0.2 0.21 0.24 0.23 1.5e-05 1.0e-05 2.1e-06 3.5e-06
3 OFC gene expression LOC134483845 0.17 0.11 4.5e-03 0.08 0.06 0.05 0.06 5.0e-03 1.6e-02 2.3e-02 1.3e-02
4 BLA gene expression LOC134483845 0.16 0.09 5.8e-08 0.08 0.11 0.11 0.11 4.4e-05 1.7e-06 1.2e-06 2.2e-06
5 RMTg gene expression LOC134483845 0.42 0.17 1.5e-08 0.23 0.21 0.26 0.1 9.3e-07 3.2e-06 1.9e-07 1.6e-03
6 Brain gene expression LOC134483845 0.5 0.12 0.0e+00 0.29 0.31 0.31 0.31 3.7e-27 2.0e-29 2.3e-29 1.5e-29
7 pVTA gene expression LOC134483845 0.38 0.11 0.0e+00 0.44 0.24 0.43 0.17 1.2e-38 1.1e-19 1.8e-37 5.9e-14
8 NAcc gene expression LOC134483845 0.25 0.1 0.0e+00 0.31 0.3 0.3 0.3 4.2e-47 6.6e-47 8.2e-47 8.3e-47
9 PL gene expression LOC134483845 0.28 0.15 0.0e+00 0.24 0.23 0.24 0.25 5.1e-26 5.4e-25 3.5e-26 1.1e-26
10 IC gene expression LOC134483845 0.32 0.12 1.8e-12 0.24 0.21 0.23 0.22 1.6e-10 2.3e-09 5.2e-10 1.4e-09
11 Adipose gene expression LOC134483845 0.05 0.04 2.8e-05 0.04 0.04 0.04 0.04 8.6e-06 2.5e-05 1.9e-05 1.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.61.02.71.71.20.81.20.80.40.90.90.70.90.9
Area under the delay curve2.02.34.1-1.6-1.6-1.5-1.7-1.1-0.8-1.6-1.7-1.5-1.1-2.0
BMI with tail1.96.69.1-2.0-2.4-2.6-2.6-2.7-3.0-2.6-2.6-2.7-2.5-2.4
BMI without tail4.112.515.3-3.4-3.7-3.6-3.5-3.9-3.8-3.5-3.6-3.5-3.2-3.2
Body weight5.624.536.0-5.9-5.3-4.7-5.1-6.0-4.3-4.8-4.9-4.2-4.6-4.3
Weight adjusted by age1.72.54.0-2.0-1.5-1.9-1.9-1.9-0.9-1.6-1.6-1.3-1.3-1.2
Bone surface0.00.00.2-0.5-0.2-0.20.1-0.40.0-0.0-0.10.0-0.10.2
Bone volume0.10.20.6-0.3-0.3-0.5-0.2-0.8-0.6-0.4-0.4-0.4-0.4-0.1
Breakpoint value in progressive ratio session0.40.51.00.60.30.60.70.90.20.80.80.81.00.9
Number of licking bursts0.61.02.80.40.81.00.81.71.41.01.00.91.00.8
Context. condit. distance diff. score9.211.113.32.63.33.43.63.03.33.43.43.63.53.5
Locomotion velocity, session 10.70.70.90.60.80.90.80.70.90.80.91.00.80.9
Locomotion distance, session 10.10.10.70.80.3-0.00.10.5-0.10.0-0.00.00.1-0.1
Locomotion velocity, session 20.10.10.10.00.20.40.10.20.40.30.30.30.30.1
Locomotion distance, session 20.20.20.50.70.60.40.40.60.50.40.40.50.50.3
Locomotion velocity, session 30.20.20.6-0.0-0.4-0.6-0.3-0.5-0.8-0.5-0.6-0.4-0.6-0.1
Locomotion distance, session 31.01.01.71.31.10.91.30.70.70.90.91.01.01.1
Stereotopy head waving bouts, day 30.60.62.5-1.6-1.0-0.7-0.9-0.7-0.3-0.7-0.7-0.4-0.7-0.3
Stereotopy head waving duration, day 30.50.61.9-1.4-0.9-0.8-1.0-0.6-0.4-0.7-0.7-0.5-0.7-0.5
Locomotion velocity, session 74.65.06.32.42.52.32.51.91.82.32.22.22.22.2
Locomotion distance, session 72.93.75.82.42.21.92.21.71.41.91.91.71.91.7
Stereotopy head waving bouts, day 72.32.64.4-2.1-1.8-1.6-1.7-1.6-1.4-1.6-1.5-1.4-1.7-1.0
Stereotopy head waving duration, day 72.32.84.6-2.1-1.8-1.7-1.8-1.7-1.5-1.6-1.6-1.5-1.7-1.2
Locomotion velocity, session 81.51.83.8-0.20.91.41.11.12.01.41.31.71.51.3
Locomotion distance, session 84.97.18.52.22.72.72.92.32.72.72.72.92.82.7
Degree of sensitization distance0.80.91.40.50.91.00.81.11.21.01.00.90.90.7
Degree of sensitization stereotypy1.11.21.7-1.3-1.2-1.1-1.1-1.0-1.1-1.1-1.1-1.0-1.2-0.6
Conditioned locomotion0.40.50.9-1.0-0.7-0.6-0.9-0.6-0.3-0.5-0.5-0.5-0.5-1.0
Cocaine response after cond. corrected0.40.51.00.90.70.60.71.00.50.60.70.60.70.5
Cocaine response after cond. not corrected0.00.00.1-0.2-0.00.20.00.20.30.10.20.30.30.0
Cocaine response before conditioning2.63.17.3-2.7-2.0-1.5-2.0-2.1-1.1-1.5-1.5-1.4-1.6-1.5
Saline control response3.04.05.6-1.3-1.8-2.0-1.9-2.4-2.2-2.0-1.9-2.2-2.1-2.1
Bone: connectivity density2.13.34.72.22.01.72.01.71.51.81.71.71.81.7
Bone: cortical apparent density0.91.21.7-0.3-0.9-1.1-1.1-1.0-1.3-1.1-1.1-1.3-1.1-1.3
Bone: cortical area1.52.33.2-1.8-1.6-1.5-1.6-1.7-1.3-1.5-1.5-1.3-1.5-1.3
Bone: cortical porosity0.70.81.0-1.0-0.9-0.9-0.9-0.7-0.7-0.9-0.9-0.9-0.8-0.9
Bone: cortical porosity0.30.30.9-1.0-0.7-0.6-0.6-0.4-0.2-0.5-0.6-0.5-0.5-0.6
Bone: cortical thickness4.98.19.1-2.0-2.7-3.0-2.9-2.8-3.0-2.9-3.0-2.9-3.0-2.7
Bone: cortical thickness2.22.63.9-0.7-1.3-1.7-1.6-1.6-2.0-1.7-1.7-1.8-1.7-1.7
Bone: cortical tissue density0.70.91.4-0.3-0.8-1.0-1.0-0.9-1.2-1.0-1.0-1.1-1.0-1.1
Condit. Reinf. active minus inactive responses0.80.91.31.11.00.91.01.01.00.90.91.00.90.8
Condit. Reinf. active-inactive response ratio0.10.10.30.1-0.2-0.2-0.4-0.1-0.3-0.3-0.2-0.5-0.4-0.6
Condit. Reinf. active responses1.31.62.51.61.31.21.41.11.11.11.21.21.11.2
Condit. Reinf. inactive responses1.41.73.71.91.51.11.61.10.91.21.11.21.21.3
Incentive salience index mean2.43.03.81.51.71.81.81.62.01.71.81.91.71.6
Condit. Reinf. lever presses4.76.67.92.02.52.62.72.22.82.62.62.82.62.6
Condit. Reinf. active minus inactive responses0.70.81.8-1.3-1.0-0.8-1.1-0.6-0.3-0.8-0.8-0.8-0.9-1.2
Condit. Reinf. active-inactive response ratio1.21.43.6-1.9-1.4-1.0-1.5-0.8-0.5-1.1-1.0-1.0-1.1-1.3
Condit. Reinf. active responses0.10.10.40.10.30.20.20.40.60.30.20.30.20.1
Condit. Reinf. inactive responses1.21.62.61.61.51.11.51.11.01.21.11.21.21.2
Condit. Reinf. lever presses0.91.21.71.01.11.01.21.31.11.01.01.11.01.2
Condit. Reinf. lever reinforcers received0.20.20.70.30.50.40.40.70.80.50.40.50.40.3
Conditioned reinforcement - actives1.22.14.1-1.3-1.7-2.0-1.3-1.1-1.6-1.5-1.4-1.5-1.2-1.2
Conditioned reinforcement - inactives1.52.23.3-1.4-1.5-1.8-1.5-1.0-1.5-1.7-1.6-1.5-1.3-1.4
Conditioned locomotion0.10.10.3-0.5-0.5-0.6-0.30.0-0.2-0.2-0.2-0.5-0.4-0.3
Patch foraging indifference point 0 sec0.71.32.7-0.6-1.1-1.6-0.9-0.8-1.5-1.3-1.4-1.0-0.9-0.6
Patch foraging indifference point AUC0.91.31.8-1.3-1.1-0.7-1.2-1.3-0.7-1.2-1.1-1.2-1.3-1.2
Delay disc. indifference point, 0s delay0.40.40.9-0.9-0.5-0.8-0.6-0.50.0-0.6-0.6-0.4-0.4-0.9
Delay disc. indifference point, 16s delay2.93.24.5-1.3-1.9-2.0-1.9-1.2-1.7-1.9-1.9-1.9-1.6-2.1
Delay disc. indifference point, 2s delay1.51.72.9-1.7-1.4-1.4-1.6-0.7-0.6-1.3-1.4-1.2-0.9-1.7
Delay disc. indifference point, 24s delay0.60.70.9-0.7-0.9-0.8-0.8-0.3-0.8-0.9-0.9-0.9-0.7-0.9
Delay disc. indifference point, 4s delay2.62.74.8-2.0-1.8-1.6-1.9-1.6-0.7-1.5-1.5-1.5-1.2-2.2
Delay disc. indifference point, 8s delay0.50.61.3-0.7-0.6-0.7-0.8-0.4-0.2-0.9-1.0-0.7-0.5-1.1
Indifference point function ln k0.50.81.80.40.70.71.00.91.10.90.81.00.71.3
Indifference point function log k0.50.81.80.40.70.71.00.91.10.90.81.00.71.3
Patch foraging total patch changes 0 sec1.01.93.5-0.8-1.4-1.9-1.1-1.0-1.8-1.6-1.7-1.3-1.2-0.8
Patch foraging total patch changes 12 sec1.72.23.1-0.8-1.3-1.6-1.4-1.2-1.6-1.8-1.7-1.6-1.3-1.6
Patch foraging total patch changes 18 sec0.71.02.2-0.1-0.7-1.0-0.6-0.9-1.5-1.3-1.3-1.1-1.1-0.7
Patch foraging total patch changes 24 sec0.20.31.30.7-0.1-0.5-0.1-0.1-1.1-0.6-0.5-0.7-0.3-0.3
Patch foraging total patch changes 6 sec1.52.33.5-0.7-1.3-1.6-1.5-1.2-1.9-1.7-1.7-1.8-1.3-1.6
Patch foraging time to switch 0 sec0.00.10.40.60.2-0.1-0.0-0.0-0.4-0.0-0.1-0.20.0-0.3
Patch foraging water rate 0 sec0.40.91.2-1.0-0.9-0.8-1.1-0.6-0.8-1.0-0.9-1.0-1.0-1.0
Patch foraging water rate 12 sec0.00.10.20.3-0.1-0.3-0.3-0.1-0.3-0.3-0.2-0.5-0.3-0.3
Patch foraging water rate 18 sec0.10.20.5-0.7-0.5-0.2-0.4-0.6-0.3-0.4-0.2-0.3-0.4-0.1
Patch foraging water rate 24 sec1.62.23.9-1.6-1.5-1.2-1.5-2.0-1.4-1.5-1.4-1.5-1.7-1.0
Patch foraging water rate 6 sec0.10.20.5-0.1-0.3-0.3-0.4-0.4-0.5-0.6-0.5-0.7-0.6-0.5
Seeking ratio, delayed vs. immediate footshock0.40.50.8-0.8-0.7-0.7-0.8-0.8-0.6-0.4-0.2-0.6-0.4-0.9
Distance traveled before self-admin0.10.10.2-0.30.1-0.10.2-0.40.40.10.20.50.20.4
Distance traveled after self-admin0.50.61.2-1.1-1.1-0.9-0.7-1.0-0.7-0.6-0.5-0.3-0.5-0.1
Extensor digitorum longus weight0.10.21.0-0.10.20.20.6-0.00.30.40.40.60.41.0
Bone: elastic displacement0.60.71.0-0.5-0.8-0.8-0.9-0.7-1.0-0.8-0.8-1.0-0.8-1.0
Bone: elastic work2.53.34.0-1.8-2.0-1.9-2.0-1.7-1.7-1.8-1.8-1.8-1.8-1.7
Bone: endosteal estimation0.30.64.7-2.2-0.8-0.0-0.4-0.80.7-0.0-0.00.30.00.1
Bone: endosteal perimeter1.12.24.1-0.31.01.61.40.92.01.61.61.81.61.7
Epididymis fat weight4.716.025.8-1.4-3.4-4.1-3.9-3.1-5.1-4.2-4.3-4.7-4.1-4.6
Delta time in closed arm before/after self-admin0.50.50.8-0.9-0.5-0.6-0.9-0.5-0.4-0.7-0.8-0.8-0.7-0.8
Delta time in open arm before/after self-admin0.20.20.6-0.4-0.8-0.7-0.2-0.7-0.6-0.3-0.4-0.1-0.4-0.3
Diff in mean of infusions in LGA sessions3.13.77.62.51.91.52.22.81.51.81.71.71.81.6
Delay discount exponential model param2.12.34.21.61.61.51.71.10.81.61.71.51.12.0
Extinction: sum of active levers before priming0.80.82.30.60.50.70.71.50.70.90.90.81.01.2
Active lever presses in extinction session 60.10.10.40.4-0.0-0.6-0.20.1-0.6-0.1-0.1-0.30.1-0.4
Bone: final force6.510.411.3-3.1-3.3-3.4-3.3-3.3-3.2-3.3-3.4-3.1-3.3-2.8
Bone: final moment5.79.210.3-3.0-3.1-3.1-3.1-3.2-3.0-3.1-3.1-2.9-3.0-2.6
Food consumed during 24 hour testing period0.20.31.7-1.0-0.5-0.2-0.4-1.3-0.1-0.2-0.2-0.2-0.3-0.2
Glucose3.35.29.70.82.02.42.21.83.12.42.52.62.42.2
Heart weight1.82.83.8-1.6-1.9-1.8-1.9-0.9-1.5-1.6-1.7-1.8-1.9-1.6
Delay discount hyperbolic model param2.22.54.41.71.61.51.81.20.81.71.81.51.22.1
Intermittent access intake day 1-15 change0.00.10.30.50.60.10.10.20.20.40.40.0-0.00.1
Intermittent access intake escalation0.10.10.40.10.1-0.4-0.4-0.5-0.4-0.2-0.1-0.5-0.4-0.6
Intermittent access intake escalation 20.10.20.60.20.80.30.2-0.10.50.40.40.40.20.2
Intermitt. access day 1 inactive lever presses0.00.10.4-0.50.00.2-0.10.60.40.10.10.20.00.6
Intermitt. access day 15 inactive lever presses0.51.01.6-1.3-1.0-1.0-0.9-1.3-0.9-1.1-1.1-0.8-1.0-0.4
Intermitt. access escalation Index2.63.74.71.91.92.22.02.01.82.12.11.82.01.4
Intermittent access day 1 total infusions0.10.20.50.2-0.7-0.50.10.5-0.7-0.3-0.3-0.20.2-0.3
Intermittent access day 15 total infusions0.30.51.0-0.1-0.8-0.9-0.5-0.3-1.0-0.5-0.6-0.7-0.3-1.0
Intermittent access terminal intake (last 3 days)0.71.01.7-0.5-1.1-1.3-0.9-0.4-1.3-0.9-1.0-1.0-0.7-1.1
Intermittent access total infusions0.50.61.2-0.4-1.0-1.1-0.6-0.3-1.1-0.8-0.8-0.7-0.5-0.9
Intermittent access day 1 locomotion0.10.10.30.0-0.40.20.20.1-0.20.20.30.00.5-0.4
Intermittent access day 15 total locomotion0.81.52.4-1.4-1.4-1.2-1.3-1.1-1.1-1.1-1.1-1.2-0.8-1.6
Intermittent access total locomotion1.11.32.2-1.3-1.5-1.2-1.1-1.1-1.0-1.0-1.0-1.1-0.7-1.4
Intermittent access standard deviation1.83.85.3-1.5-1.9-2.3-2.1-1.8-2.1-1.8-1.8-2.0-2.1-1.8
Left kidney weight4.521.129.4-4.9-4.9-4.5-4.7-5.4-4.5-4.3-4.3-4.2-4.6-4.0
Right kidney weight4.922.131.7-5.2-5.0-4.6-4.9-5.6-4.2-4.3-4.5-4.3-4.5-4.5
Cocaine induced anxiety0.91.31.80.71.11.31.30.91.31.11.11.31.11.2
Post-drug Anxiety0.80.81.20.71.10.81.00.61.10.80.71.10.90.9
Baseline Anxiety0.10.10.60.70.4-0.30.10.80.20.10.10.10.2-0.0
Tail length2.18.220.8-4.6-3.4-2.5-2.9-3.7-1.6-2.6-2.6-1.9-2.3-2.1
Length with tail2.912.631.1-5.6-4.1-3.1-3.6-4.8-2.0-3.1-3.2-2.3-3.0-2.6
Length without tail3.19.919.6-4.4-3.5-2.9-3.4-3.9-2.2-2.9-2.9-2.4-3.0-2.5
Times rat made contact with spout0.20.31.71.30.60.20.50.3-0.40.30.20.10.20.2
Lifetime Intake0.91.12.1-0.8-1.3-1.5-0.8-0.5-1.3-1.1-1.1-0.9-0.6-1.2
Liver weight, left0.20.30.9-1.0-0.20.40.1-0.60.70.60.60.60.60.3
Liver weight, right0.71.25.3-2.3-1.4-0.9-1.1-1.50.0-0.5-0.5-0.4-0.3-0.8
Locomotor activity0.20.31.5-1.20.20.4-0.1-0.90.80.30.30.50.10.3
Locomotor testing distance0.20.30.9-0.50.50.60.4-0.10.90.40.50.70.30.7
Locomotor testing rearing0.10.20.9-0.9-0.30.2-0.1-0.80.3-0.0-0.00.2-0.1-0.1
Locomotion in novel chamber0.70.92.0-1.0-1.0-1.1-0.7-1.4-0.9-1.0-0.8-0.6-0.8-0.6
Locomotion in novel chamber post-restriction1.01.73.0-1.1-1.0-1.7-1.6-1.3-1.0-1.2-1.3-1.2-1.1-1.5
Fecal boli incidents, locomotor time 10.50.71.11.10.50.91.11.00.20.60.60.80.61.0
Change in fecal boli incidents, locomotor task0.40.40.9-0.9-0.7-0.6-0.90.2-0.4-0.6-0.6-0.6-0.7-0.6
Time >=10cm from walls, locomotor time 10.10.10.6-0.8-0.5-0.0-0.3-0.2-0.2-0.2-0.20.00.10.2
Bouts of movement, locomotor time 11.01.12.01.01.20.91.20.41.41.11.11.30.90.6
Total resting periods, locomotor time 10.50.61.10.70.80.50.80.41.10.80.81.10.70.4
Rest time, locomotor task time 10.10.10.1-0.30.30.1-0.2-0.30.20.20.20.30.3-0.2
Distance moved, locomotor task time 10.50.81.5-0.7-1.0-1.2-0.8-0.7-1.0-0.8-0.8-1.1-1.0-0.3
Vertical activity count, locomotor time 10.20.40.8-0.5-0.6-0.6-0.6-0.6-0.7-0.6-0.6-0.8-0.9-0.1
Time >=10cm from walls, locomotor time 20.10.10.4-0.3-0.10.4-0.00.60.20.30.30.10.00.1
Bouts of movement, locomotor time 20.20.31.7-0.80.20.4-0.3-1.30.40.10.10.20.0-0.3
Total resting periods, locomotor time 20.20.41.1-0.60.60.80.1-1.00.80.40.40.60.40.1
Rest time, locomotor task time 21.41.82.80.41.31.51.20.61.51.61.61.71.41.4
Distance moved, locomotor task time 21.92.33.3-0.9-1.5-1.8-1.5-1.1-1.5-1.5-1.5-1.8-1.6-1.5
Vertical activity count, locomotor time 20.20.30.6-0.1-0.3-0.5-0.70.3-0.3-0.5-0.5-0.7-0.4-0.8
Light reinforcement 10.10.20.5-0.2-0.4-0.7-0.40.1-0.4-0.7-0.7-0.5-0.6-0.3
Light reinforcement 20.30.41.0-1.0-0.7-0.6-0.7-0.7-0.3-0.6-0.5-0.5-0.5-0.6
Bone: marrow area0.30.64.7-2.2-0.8-0.0-0.5-0.80.6-0.1-0.00.2-0.00.1
Bone: maximum diameter0.20.30.7-0.9-0.00.50.40.10.80.40.50.70.50.8
Bone: maximum force4.78.39.4-2.9-3.0-3.0-3.0-3.1-2.7-2.8-2.9-2.8-2.8-2.7
Bone: maximum moment4.07.18.8-2.8-2.8-2.7-2.7-3.0-2.5-2.6-2.6-2.5-2.6-2.5
Mean time between licks in bursts0.71.72.90.11.01.51.20.71.71.41.51.51.51.3
Mean num. licks in bursts0.50.82.30.3-0.4-0.8-0.4-1.4-1.5-0.8-0.8-0.9-0.8-0.7
Cd content in liver0.10.10.60.1-0.0-0.1-0.4-0.1-0.4-0.1-0.1-0.40.1-0.8
Co content in liver1.51.72.5-0.8-1.2-1.3-1.5-0.9-1.5-1.3-1.3-1.6-1.4-1.5
Cu content in liver0.60.72.81.71.10.71.00.90.40.60.60.40.70.3
Fe content in liver1.21.52.1-0.7-1.1-1.2-1.3-1.3-1.4-1.2-1.2-1.4-1.2-1.5
K content in liver0.10.10.30.50.40.30.40.20.10.10.10.1-0.20.6
Mg content in liver1.71.82.41.01.31.41.51.41.51.31.21.31.21.4
Mn content in liver4.85.38.01.42.22.42.42.12.82.32.32.52.22.4
Na content in liver0.80.91.8-0.3-0.8-0.9-1.0-0.6-0.8-0.9-0.9-1.3-1.2-1.2
Rb content in liver0.91.01.51.11.11.11.21.01.10.91.00.80.90.7
Se content in liver1.31.53.80.41.11.50.91.02.01.41.41.21.30.6
Sr content in liver0.20.20.6-0.8-0.5-0.4-0.5-0.4-0.1-0.4-0.3-0.3-0.4-0.2
Zn content in liver0.10.10.20.10.30.40.40.10.40.40.30.40.40.5
Bone: minimum diameter0.20.41.1-1.00.10.50.30.01.10.60.60.80.50.8
Time in familiar zone, hab. session 10.90.93.31.81.10.80.91.00.30.90.90.50.70.4
Time in novel zone, hab. session 10.30.31.8-1.3-0.7-0.4-0.5-0.7-0.0-0.4-0.5-0.1-0.3-0.1
Total zone transitions, hab. session 10.60.91.41.11.00.81.11.20.70.80.71.00.81.2
Total locomotion distance, hab. session 10.40.51.20.90.70.50.81.00.40.50.40.80.51.1
Locomotion velocity, hab. session 10.10.20.50.50.30.10.40.70.00.10.10.40.10.7
Time in familiar zone, hab. session 20.00.00.10.30.10.10.2-0.1-0.30.00.1-0.00.10.1
Time in novel zone, hab. session 20.10.10.2-0.4-0.4-0.3-0.4-0.4-0.2-0.3-0.4-0.3-0.4-0.4
Total zone transitions, hab. session 20.10.10.40.1-0.1-0.2-0.40.6-0.0-0.3-0.3-0.2-0.2-0.5
Total locomotion distance, hab. session 20.70.92.41.21.00.70.81.50.70.70.70.80.80.7
Locomotion velocity, hab. session 20.81.13.01.31.10.80.91.70.90.80.80.90.90.8
Novel to familiar place preference ratio0.10.10.20.0-0.2-0.4-0.00.2-0.2-0.3-0.4-0.2-0.30.2
Novelty place preference0.10.10.3-0.2-0.4-0.5-0.2-0.0-0.3-0.5-0.5-0.3-0.5-0.0
Time in novel zone, NPP test0.20.20.4-0.4-0.5-0.6-0.3-0.1-0.4-0.5-0.6-0.4-0.5-0.1
Total zone transitions, NPP test1.01.52.41.41.31.11.21.51.11.11.11.21.21.0
Total locomotion distance, NPP test0.60.81.81.31.00.70.91.20.50.70.60.80.70.9
Locomotion velocity, NPP test1.11.63.21.81.41.01.41.70.81.01.01.21.11.3
Intraocular pressure0.60.81.31.10.81.11.00.30.41.11.01.01.00.7
Delta distance traveled before/after self-admin1.81.93.2-1.4-1.8-1.4-1.5-1.1-1.6-1.3-1.3-1.3-1.4-1.0
Delta ambulatory time before/after self-admin0.91.12.1-1.3-1.5-1.0-1.2-0.9-1.3-0.9-0.9-0.9-1.0-0.4
Parametrial fat weight1.33.16.3-1.6-1.7-2.1-1.4-2.5-1.8-1.7-1.7-1.6-1.7-1.2
Pavlov. Cond. lever latency2.32.94.7-0.8-1.5-1.9-1.7-1.1-2.2-1.8-1.9-2.0-1.7-1.9
Pavlov. Cond. magazine entry latency3.03.85.41.21.92.11.91.62.32.12.12.22.11.7
Pavlov. Cond. change in total contacts0.10.10.4-0.50.00.30.0-0.20.70.30.30.40.20.2
Pavlov. Cond. index score3.64.56.91.22.02.32.01.62.62.32.32.42.22.0
Pavlov. Cond. latency score2.83.55.80.91.72.11.81.32.42.02.12.11.91.9
Pavlov. Cond. lever contacts2.02.44.20.61.41.71.41.12.01.71.71.81.51.7
Pavlov. Cond. magazine entry number3.84.76.0-1.6-2.2-2.3-2.1-1.9-2.5-2.3-2.3-2.3-2.3-1.9
Pavlov. Cond. intertrial magazine entries0.20.20.60.7-0.0-0.4-0.2-0.2-0.7-0.3-0.4-0.5-0.3-0.7
Pavlov. Cond. lever-magazine prob. diff.3.94.87.11.32.12.42.11.72.72.42.42.42.32.0
Pavlov. Cond. response bias4.15.16.91.52.22.42.21.82.62.42.42.52.42.1
Pavlov. Cond. lever latency0.10.20.5-0.7-0.6-0.4-0.4-0.6-0.3-0.4-0.4-0.3-0.4-0.2
Pavlov. Cond. magazine entry latency0.10.10.5-0.7-0.5-0.4-0.4-0.2-0.2-0.3-0.4-0.2-0.3-0.2
Pavlov. Cond. change in total contacts0.20.30.4-0.5-0.5-0.6-0.6-0.1-0.3-0.6-0.6-0.6-0.6-0.6
Pavlov. Cond. index score0.00.00.1-0.10.10.0-0.00.20.20.10.00.10.1-0.0
Pavlov. Cond. latency score0.00.00.1-0.2-0.2-0.3-0.30.0-0.0-0.2-0.2-0.1-0.2-0.2
Pavlov. Cond. lever contacts0.00.10.20.40.40.20.20.40.20.20.20.10.20.0
Pavlov. Cond. magazine entry number0.20.30.40.60.50.60.60.30.40.40.50.40.40.5
Pavlov. Cond. intertrial magazine entries1.82.63.71.21.61.81.71.41.91.71.71.71.81.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.00.10.10.00.30.20.10.10.10.10.0
Pavlov. Cond. response bias0.20.20.30.40.50.50.40.50.60.50.50.50.50.3
Time in closed arm before self-admin0.10.20.30.60.50.10.50.50.50.30.50.30.20.5
Time in closed arm after self-admin1.31.32.3-0.8-0.8-1.2-1.3-0.7-0.8-1.4-1.3-1.4-1.2-1.5
Time in open arm before self-admin0.50.51.20.20.50.90.80.40.50.70.70.81.10.7
Time in open arm after self-admin0.50.51.20.30.10.60.80.30.20.90.71.11.00.9
Bone: periosteal estimation0.71.55.8-2.4-1.5-0.9-1.3-1.5-0.4-0.9-0.9-0.7-0.9-0.7
Bone: periosteal perimeter0.10.21.4-1.2-0.5-0.0-0.2-0.50.3-0.0-0.00.1-0.00.1
Bone: post-yield work1.11.62.60.21.11.51.30.61.61.51.41.51.41.1
Progressive ratio test 1 active lever presses0.40.51.3-0.3-1.2-1.0-0.30.1-0.9-0.7-0.7-0.7-0.6-0.5
Progressive ratio test 1 breakpoint0.50.61.5-0.4-1.2-1.1-0.40.0-0.9-0.8-0.8-0.7-0.6-0.5
Progressive ratio test 1 inactive lever presses0.40.51.0-0.1-0.8-1.0-0.50.2-1.0-0.8-0.7-0.9-0.6-0.8
Progressive ratio test 2 active lever presses0.10.10.20.4-0.2-0.40.00.5-0.4-0.1-0.1-0.30.1-0.4
Progressive ratio test 2 breakpoint0.10.10.30.3-0.2-0.5-0.00.3-0.5-0.2-0.2-0.30.1-0.5
Progressive ratio test 2 inactive lever presses0.30.61.4-0.8-1.0-1.2-0.6-0.1-0.9-0.7-0.7-0.7-0.4-0.6
Incentive Sensitization - Responses0.40.51.20.90.90.60.51.10.50.70.70.50.90.3
Incentive Sensitization - Breakpoint0.40.51.01.00.90.60.51.00.40.70.70.40.90.3
Sum of active levers in priming session hrs 5-60.50.51.10.50.50.60.40.80.50.90.90.61.10.7
Progressive ratio5.79.010.7-2.9-3.2-3.3-3.2-3.1-2.8-3.0-2.8-2.9-2.6-3.1
Food seeking constrained by brief footshock0.00.00.20.40.20.20.3-0.1-0.20.20.10.10.10.2
Seeking ratio, punishment vs. effort5.07.29.72.82.93.12.92.82.32.72.52.52.32.7
Retroperitoneal fat weight0.62.74.2-1.6-1.5-1.8-1.6-2.1-1.4-1.5-1.6-1.5-1.3-1.9
Reaction time number correct0.40.81.3-0.3-0.7-0.7-0.8-0.8-1.1-1.1-1.1-1.1-1.1-0.7
Reaction time mean minus median0.81.93.4-0.11.11.81.2-0.41.81.61.51.81.70.9
Reaction time mean minus median AUC0.71.73.00.21.21.71.1-0.21.71.61.51.61.60.7
Reaction time num false alarms0.10.20.7-0.8-0.4-0.8-0.4-0.10.0-0.4-0.5-0.2-0.5-0.0
Reaction time num false alarms AUC0.20.41.1-1.0-0.7-0.9-0.6-0.1-0.1-0.6-0.7-0.4-0.7-0.0
Reaction time trials correct on left0.40.81.3-0.3-0.7-0.7-0.8-0.8-1.1-1.1-1.1-1.1-1.1-0.7
Reaction time trials on left0.40.81.2-0.3-0.7-0.7-0.8-0.8-1.1-1.1-1.0-1.1-1.1-0.7
Reaction time mean2.03.25.40.51.62.01.70.82.31.91.92.32.01.7
Reaction time mean AUC2.03.15.20.51.62.01.60.72.32.02.02.22.01.5
Median of all reaction times1.72.44.00.61.31.61.51.02.01.61.61.91.71.5
Reaction time omissions1.11.62.60.10.91.51.20.61.61.41.31.61.61.1
Reaction time false alarm rate0.10.20.5-0.7-0.2-0.4-0.00.50.60.10.00.40.10.5
Reaction time premature initiation rate1.52.12.9-1.6-1.7-1.4-1.4-1.1-1.2-1.7-1.6-1.4-1.6-0.8
Reaction time premature initiations2.13.75.3-1.7-2.1-1.9-1.9-1.5-1.8-2.3-2.2-2.1-2.2-1.3
Std. dev. reaction times0.91.83.3-0.30.91.61.1-0.01.81.51.51.81.61.0
Reaction time trials completed0.40.81.2-0.3-0.7-0.7-0.8-0.8-1.1-1.1-1.0-1.1-1.1-0.7
Reaction time trials AUC0.40.71.1-0.2-0.7-0.6-0.7-0.7-1.0-1.0-1.0-1.0-1.0-0.6
Run reversals in cocaine runway, females0.20.21.00.0-0.6-0.6-0.20.2-1.0-0.5-0.6-0.5-0.30.1
Run reversals in cocaine runway, males0.40.41.8-1.4-0.70.1-0.2-1.20.2-0.2-0.20.20.20.1
Latency to leave start box in cocaine runway0.10.20.40.20.50.50.20.60.40.50.50.10.20.1
Latency to leave start box in cocaine runway, F0.60.71.30.61.01.00.90.60.90.80.80.70.61.1
Latency to leave start box in cocaine runway, M0.90.92.7-0.8-0.8-0.8-1.2-0.5-0.9-0.6-0.6-1.2-0.7-1.6
Std. dev. time between licks in bursts0.81.12.4-0.20.71.20.81.01.61.11.21.21.11.1
Total sessions with >9 infusions0.80.91.5-0.9-1.2-1.2-0.8-0.6-1.1-1.0-0.9-0.9-0.7-1.0
Short access day 1 total inactive lever presses1.11.43.7-1.9-1.3-0.9-1.2-1.3-0.7-1.2-1.2-0.9-0.9-1.1
Short access day 10 total inactive lever presses0.30.71.10.60.70.90.81.00.51.01.00.50.61.0
Short access day 1 total infusions0.10.10.3-0.2-0.4-0.6-0.20.2-0.2-0.3-0.3-0.10.0-0.6
Short access day 10 total infusions0.60.81.6-0.6-1.0-1.3-0.7-0.5-1.1-1.0-1.0-0.8-0.7-0.9
Short access total infusions1.11.32.5-1.0-1.5-1.6-0.9-0.6-1.3-1.3-1.3-1.0-0.8-1.2
Short access day 1 locomotion1.01.22.41.31.00.91.01.60.91.21.20.91.20.4
Short access day 10 total locomotion0.10.10.3-0.5-0.1-0.4-0.40.30.50.10.1-0.2-0.2-0.3
Short access total locomotion0.10.10.5-0.1-0.2-0.2-0.00.70.30.10.1-0.10.0-0.1
One hour access (0.3 mA shock)1.01.23.11.30.80.41.21.80.41.11.10.91.21.1
Compulsive drug intake5.26.28.82.12.22.32.62.92.32.62.62.32.23.0
One hour access (shock baseline)0.81.32.2-0.7-1.1-1.4-1.1-1.1-1.5-1.0-1.1-1.0-0.5-1.4
Social response proportion0.00.00.1-0.3-0.10.1-0.10.20.30.10.10.30.10.1
Social responses0.20.30.7-0.6-0.5-0.4-0.70.1-0.2-0.4-0.4-0.5-0.6-0.9
Social time0.81.12.3-0.30.71.00.80.51.51.21.21.31.11.2
Soleus weight0.41.12.5-0.80.30.80.81.01.60.91.01.30.91.4
Bone: stiffness1.22.02.7-1.1-1.3-1.4-1.5-1.6-1.5-1.3-1.4-1.4-1.4-1.6
Tibialis anterior weight0.30.91.8-0.2-0.8-1.2-0.7-0.9-1.3-1.0-1.1-1.1-1.1-0.7
Time to tail flick, vehicle, before self-admin1.11.21.91.01.30.81.30.31.21.31.41.00.71.0
Time to tail flick, vehicle, after self-admin0.91.21.80.81.10.81.10.71.21.31.31.21.31.1
Time to tail flick, test, before self-admin0.10.10.30.10.1-0.00.2-0.5-0.10.30.30.10.30.2
Time to tail flick, test, after self-admin0.70.71.20.71.11.00.8-0.20.91.00.90.91.10.4
Delta time to tail flick, vehicle, before/after SA0.00.00.20.20.00.1-0.10.2-0.3-0.0-0.10.00.4-0.2
Delta time to tail flick, test, before/after SA0.30.30.70.80.80.70.50.60.60.50.40.40.40.3
Tibia length0.92.67.1-2.7-1.8-1.2-1.8-2.1-0.6-1.3-1.4-1.0-1.2-1.6
Ambulatory time before self-admin0.10.10.3-0.3-0.1-0.5-0.0-0.60.2-0.2-0.20.1-0.2-0.1
Ambulatory time after self-admin0.81.02.2-1.4-1.5-1.1-0.8-1.1-1.0-0.7-0.7-0.5-0.9-0.0
Bone: tissue strength4.44.55.5-2.3-2.4-2.1-2.0-2.4-2.1-2.1-2.1-2.0-2.2-1.5
Total heroin consumption0.10.10.4-0.1-0.3-0.00.30.0-0.10.50.50.30.30.6
Bone: trabecular number0.50.82.81.71.10.61.00.70.20.70.70.60.70.8
Bone: trabecular spacing2.22.96.0-2.4-2.0-1.5-1.8-1.8-1.2-1.6-1.6-1.4-1.6-1.4
Bone: trabecular thickness0.50.61.91.41.00.70.90.40.30.80.80.60.80.6
Bone: trabecular tissue density1.72.54.1-1.6-1.5-1.5-2.0-1.3-1.3-1.4-1.4-1.7-1.5-2.0
Water consumed over 24 hours0.00.00.1-0.00.10.00.10.00.10.10.00.10.00.3
Number of responses in last shaping day0.30.41.0-1.0-0.9-0.8-0.70.0-0.2-0.5-0.5-0.3-0.5-0.4