Hub : Genes

LOC134483641

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC134483641	0.16	0.05	0.0e+00	0.15	0.22	0.22	0.21	1.5e-22	2.8e-32	5.0e-32	1.3e-30
2	Brain	gene expression	LOC134483641	0.06	0.04	1.3e-03	0.02	0.02	0.02	0.02	2.6e-03	7.8e-03	1.1e-02	5.8e-03
3	PL	gene expression	LOC134483641	0.07	0.03	2.3e-07	0.1	0.07	0.09	0.1	9.0e-11	2.7e-08	8.0e-10	1.4e-10
4	NAcc	intron excision ratio	chr19_54131924_54153610	0.03	0.02	9.9e-04	0.03	0.02	0.02	0.02	8.8e-05	7.2e-04	6.7e-04	1.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.2	0.3	-0.0	-0.6	-0.5	0.4
Area under the delay curve	0.2	0.2	0.5	0.3	-0.3	-0.7	0.5
BMI with tail	0.9	3.2	3.8	1.8	-1.5	-1.9	-1.9
BMI without tail	0.3	1.8	2.8	1.4	-1.0	-1.2	-1.7
Body weight	2.7	11.8	14.0	3.7	-3.4	-3.6	-2.9
Weight adjusted by age	0.2	0.7	1.3	0.5	-1.1	-1.1	-0.3
Bone surface	2.0	3.8	5.8	2.4	-2.0	-2.1	-1.1
Bone volume	1.1	2.1	3.2	1.8	-1.5	-1.5	-0.8
Breakpoint value in progressive ratio session	0.3	0.5	0.8	-0.6	0.9	0.5	0.6
Number of licking bursts	0.0	0.1	0.3	-0.1	0.0	0.6	0.3
Context. condit. distance diff. score	0.1	0.2	0.4	0.6	0.3	0.4	-0.2
Locomotion velocity, session 1	0.5	0.6	1.4	0.4	-0.6	-1.2	0.6
Locomotion distance, session 1	0.2	0.3	0.7	-0.3	-0.5	-0.2	0.8
Locomotion velocity, session 2	0.2	0.2	0.9	0.0	0.0	0.4	0.9
Locomotion distance, session 2	1.2	1.7	3.1	0.9	-1.8	-1.6	-0.5
Locomotion velocity, session 3	1.1	1.3	3.5	-1.3	-0.2	-0.2	1.9
Locomotion distance, session 3	0.2	0.2	0.5	-0.2	-0.7	-0.5	0.3
Stereotopy head waving bouts, day 3	4.6	5.5	8.4	-2.3	2.3	1.9	2.9
Stereotopy head waving duration, day 3	2.2	2.7	6.1	-1.3	1.3	1.1	2.5
Locomotion velocity, session 7	0.4	0.4	0.9	-0.8	-0.4	-0.0	0.9
Locomotion distance, session 7	1.0	1.2	2.2	0.9	-1.5	-1.2	-0.7
Stereotopy head waving bouts, day 7	6.7	7.8	9.5	-2.8	2.7	2.6	3.1
Stereotopy head waving duration, day 7	7.5	9.3	11.2	-3.1	2.9	2.8	3.4
Locomotion velocity, session 8	0.8	1.0	1.3	1.1	-1.0	-1.1	-0.6
Locomotion distance, session 8	0.5	0.7	1.2	1.1	-0.9	-0.9	-0.5
Degree of sensitization distance	0.7	0.7	1.1	1.0	-0.5	-0.7	-1.1
Degree of sensitization stereotypy	5.0	5.5	7.2	-2.5	2.0	2.1	2.7
Conditioned locomotion	0.3	0.3	0.5	0.7	-0.5	-0.5	-0.4
Cocaine response after cond. corrected	0.4	0.6	1.2	0.0	-1.1	-1.0	-0.3
Cocaine response after cond. not corrected	0.3	0.4	0.7	0.1	-0.8	-0.8	-0.4
Cocaine response before conditioning	0.1	0.1	0.3	-0.1	0.5	0.6	0.1
Saline control response	0.6	0.9	2.1	1.5	-0.9	-0.8	0.0
Bone: connectivity density	0.3	0.5	1.0	0.7	-1.0	-0.8	-0.1
Bone: cortical apparent density	0.5	0.7	1.2	-1.1	1.0	0.9	0.2
Bone: cortical area	3.2	5.2	7.4	2.7	-2.5	-2.1	-1.6
Bone: cortical porosity	0.2	0.2	0.5	-0.2	0.7	0.2	0.6
Bone: cortical porosity	0.1	0.2	0.5	0.0	0.3	-0.2	0.7
Bone: cortical thickness	0.6	1.0	1.6	1.1	-1.2	-0.9	-0.7
Bone: cortical thickness	0.4	0.5	0.7	0.8	-0.8	-0.8	-0.4
Bone: cortical tissue density	0.4	0.7	1.1	-1.1	0.9	0.8	0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.2	0.3	0.2	-0.5
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.2	-0.5	1.1	0.6	-0.6
Condit. Reinf. active responses	0.2	0.2	0.6	0.3	-0.3	-0.4	-0.8
Condit. Reinf. inactive responses	0.7	0.9	1.6	0.9	-1.2	-1.0	-0.7
Incentive salience index mean	0.4	0.5	1.0	0.8	-0.5	-0.3	-1.0
Condit. Reinf. lever presses	0.9	1.4	2.5	1.6	-1.2	-0.5	-1.2
Condit. Reinf. active minus inactive responses	2.1	3.3	6.5	1.3	-2.6	-2.2	0.5
Condit. Reinf. active-inactive response ratio	0.9	1.4	3.0	0.5	-1.7	-1.4	0.8
Condit. Reinf. active responses	1.7	2.4	4.1	1.5	-2.0	-1.8	0.4
Condit. Reinf. inactive responses	0.3	0.5	1.3	1.1	-0.3	-0.5	-0.4
Condit. Reinf. lever presses	0.4	0.5	1.1	1.0	-0.9	-0.5	0.0
Condit. Reinf. lever reinforcers received	1.4	2.0	3.3	1.4	-1.8	-1.7	0.3
Conditioned reinforcement - actives	0.2	0.6	1.8	-0.3	-0.8	-1.3	-0.0
Conditioned reinforcement - inactives	0.1	0.3	0.4	0.2	-0.7	-0.6	-0.4
Conditioned locomotion	1.4	2.1	3.8	0.7	-1.9	-2.0	-0.5
Patch foraging indifference point 0 sec	0.1	0.3	0.5	-0.2	0.7	0.7	0.3
Patch foraging indifference point AUC	0.4	0.9	3.2	0.0	-0.6	0.1	1.8
Delay disc. indifference point, 0s delay	1.8	2.0	2.5	-1.2	1.6	1.3	1.5
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	-0.3	0.2	-0.1	0.6
Delay disc. indifference point, 2s delay	1.0	1.1	2.0	1.3	-0.8	-1.4	0.1
Delay disc. indifference point, 24s delay	0.6	1.0	1.4	1.1	-0.6	-0.8	-1.2
Delay disc. indifference point, 4s delay	0.7	0.7	2.7	-0.4	0.2	-0.1	1.7
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.0	-0.2	-0.1	0.2
Indifference point function ln k	0.4	1.2	4.2	0.6	0.5	0.0	-2.0
Indifference point function log k	0.4	1.2	4.2	0.6	0.5	0.0	-2.0
Patch foraging total patch changes 0 sec	0.1	0.4	0.8	-0.1	0.9	0.8	0.2
Patch foraging total patch changes 12 sec	0.2	0.3	0.4	0.5	-0.7	-0.1	0.6
Patch foraging total patch changes 18 sec	0.2	0.5	0.9	-0.9	0.4	0.5	0.9
Patch foraging total patch changes 24 sec	0.2	0.8	2.1	-0.3	1.1	1.5	0.1
Patch foraging total patch changes 6 sec	0.2	0.3	0.8	0.9	-0.7	0.0	-0.2
Patch foraging time to switch 0 sec	0.0	0.2	0.4	-0.4	-0.1	-0.5	-0.6
Patch foraging water rate 0 sec	0.0	0.1	0.3	0.6	0.1	0.1	0.2
Patch foraging water rate 12 sec	0.3	1.2	2.5	-0.2	1.6	1.6	0.1
Patch foraging water rate 18 sec	0.3	0.6	1.2	1.1	0.2	0.4	-1.1
Patch foraging water rate 24 sec	1.1	1.6	2.7	-1.1	1.3	1.6	0.9
Patch foraging water rate 6 sec	0.2	0.3	0.5	0.4	0.6	0.7	0.6
Seeking ratio, delayed vs. immediate footshock	1.2	1.7	4.0	0.2	-1.6	-2.0	-0.2
Distance traveled before self-admin	0.1	0.2	0.5	0.7	-0.3	-0.6	-0.0
Distance traveled after self-admin	0.0	0.0	0.1	0.1	0.2	0.2	0.3
Extensor digitorum longus weight	0.2	0.6	1.8	1.3	-0.1	0.2	-0.9
Bone: elastic displacement	0.5	0.7	1.1	-1.0	0.7	0.8	0.6
Bone: elastic work	0.2	0.3	0.5	0.6	-0.7	-0.3	-0.5
Bone: endosteal estimation	3.0	7.3	10.8	3.3	-2.5	-2.6	-2.3
Bone: endosteal perimeter	3.1	7.7	11.2	3.3	-2.8	-2.6	-2.2
Epididymis fat weight	0.8	4.0	5.4	2.3	-1.8	-1.8	-2.0
Delta time in closed arm before/after self-admin	0.3	0.3	0.4	-0.2	-0.7	-0.5	0.5
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.2	0.5	0.2	-0.1
Diff in mean of infusions in LGA sessions	0.2	0.4	0.7	0.8	-0.4	-0.6	-0.6
Delay discount exponential model param	0.3	0.5	1.0	-0.7	0.6	1.0	-0.2
Extinction: sum of active levers before priming	0.3	0.4	1.3	-0.5	0.2	0.1	1.2
Active lever presses in extinction session 6	0.5	0.5	1.1	-0.9	0.5	-0.1	1.0
Bone: final force	2.0	3.3	5.5	2.3	-1.6	-1.2	-1.9
Bone: final moment	2.1	3.4	5.2	2.3	-1.7	-1.3	-1.9
Food consumed during 24 hour testing period	0.3	0.5	0.9	0.9	-0.9	-0.6	-0.3
Glucose	0.5	0.8	1.7	0.8	-0.3	-0.8	-1.3
Heart weight	1.2	1.9	2.8	1.7	-0.9	-1.5	-1.4
Delay discount hyperbolic model param	0.3	0.4	0.9	-0.6	0.6	1.0	-0.4
Intermittent access intake day 1-15 change	0.6	3.2	4.3	-2.0	2.1	2.0	0.8
Intermittent access intake escalation	0.3	1.8	2.5	-1.6	1.6	1.4	0.6
Intermittent access intake escalation 2	0.5	0.8	1.2	-1.0	1.1	1.0	0.2
Intermitt. access day 1 inactive lever presses	0.1	0.7	1.7	-0.2	-1.3	-1.0	-0.2
Intermitt. access day 15 inactive lever presses	0.3	1.4	2.3	0.8	-1.5	-1.5	-0.7
Intermitt. access escalation Index	0.0	0.2	0.3	0.3	-0.6	0.1	0.4
Intermittent access day 1 total infusions	0.5	1.6	3.0	-1.6	0.0	-0.8	1.7
Intermittent access day 15 total infusions	0.4	0.9	2.7	-1.6	0.6	-0.2	0.7
Intermittent access terminal intake (last 3 days)	1.0	1.7	4.5	-2.1	1.3	0.5	0.7
Intermittent access total infusions	0.7	0.9	2.6	-1.6	0.5	-0.4	0.6
Intermittent access day 1 locomotion	0.4	0.7	1.2	-0.9	-0.2	-0.9	1.1
Intermittent access day 15 total locomotion	0.2	0.8	2.2	-1.5	0.7	0.1	0.8
Intermittent access total locomotion	0.7	0.9	2.2	-1.5	0.6	-0.3	0.9
Intermittent access standard deviation	0.1	0.4	1.1	-0.3	-0.5	-1.1	-0.1
Left kidney weight	2.6	21.2	33.3	5.8	-3.7	-3.8	-4.9
Right kidney weight	2.6	17.9	28.7	5.4	-3.5	-3.3	-4.4
Cocaine induced anxiety	0.0	0.1	0.2	0.4	-0.4	-0.1	-0.2
Post-drug Anxiety	0.0	0.0	0.0	-0.1	0.2	0.2	0.2
Baseline Anxiety	0.4	0.7	1.2	-0.8	1.1	0.8	0.6
Tail length	0.3	1.6	2.9	1.7	-1.3	-1.0	-1.0
Length with tail	1.3	5.9	7.9	2.8	-2.7	-2.4	-1.5
Length without tail	0.4	2.3	3.2	1.8	-1.6	-1.7	-0.8
Times rat made contact with spout	0.3	0.4	0.8	-0.4	-0.7	-0.9	0.1
Lifetime Intake	0.6	0.7	1.8	-1.3	0.2	-0.9	0.5
Liver weight, left	0.3	0.5	1.1	-0.6	0.5	0.5	1.0
Liver weight, right	1.8	3.1	5.4	2.3	-1.4	-1.2	-1.9
Locomotor activity	2.1	3.2	4.2	2.0	-2.0	-1.8	-1.2
Locomotor testing distance	0.0	0.0	0.1	-0.1	-0.0	-0.2	0.0
Locomotor testing rearing	0.0	0.0	0.0	0.1	0.2	-0.0	0.2
Locomotion in novel chamber	0.1	0.2	0.5	-0.2	-0.5	-0.1	0.7
Locomotion in novel chamber post-restriction	0.3	1.0	1.5	1.2	-0.8	-1.2	-0.8
Fecal boli incidents, locomotor time 1	0.2	0.6	0.8	0.9	-0.9	-0.8	-0.5
Change in fecal boli incidents, locomotor task	0.3	0.4	0.8	0.4	0.6	0.9	-0.4
Time >=10cm from walls, locomotor time 1	1.1	1.3	2.3	1.0	-1.1	-1.5	-0.9
Bouts of movement, locomotor time 1	2.8	3.6	5.5	-1.6	2.1	2.3	1.4
Total resting periods, locomotor time 1	3.2	3.6	5.4	-1.7	2.1	2.3	1.4
Rest time, locomotor task time 1	1.6	2.6	4.3	-1.7	1.3	2.1	1.3
Distance moved, locomotor task time 1	1.2	3.5	4.8	1.7	-1.9	-2.2	-1.7
Vertical activity count, locomotor time 1	0.2	1.5	2.2	1.1	-1.4	-1.5	-0.6
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.3	-0.5	0.1	0.0	0.2
Bouts of movement, locomotor time 2	0.7	2.4	5.6	-0.7	2.4	1.7	0.8
Total resting periods, locomotor time 2	0.4	1.8	4.6	-0.5	2.1	1.4	0.5
Rest time, locomotor task time 2	0.9	1.6	3.4	-1.0	1.8	1.4	-0.1
Distance moved, locomotor task time 2	0.9	1.1	1.9	0.9	-1.4	-1.3	-0.4
Vertical activity count, locomotor time 2	0.3	0.6	1.3	0.4	-1.1	-0.0	1.1
Light reinforcement 1	0.1	0.6	0.8	0.9	-0.8	-0.7	0.6
Light reinforcement 2	0.1	0.2	0.6	0.3	0.1	-0.4	0.7
Bone: marrow area	2.8	6.9	10.2	3.2	-2.4	-2.6	-2.1
Bone: maximum diameter	3.6	7.2	10.7	3.3	-2.9	-2.5	-1.9
Bone: maximum force	3.1	6.0	9.6	3.1	-2.4	-2.2	-2.0
Bone: maximum moment	3.3	6.3	9.2	3.0	-2.5	-2.4	-2.1
Mean time between licks in bursts	0.2	1.0	1.7	-1.0	0.9	1.3	0.6
Mean num. licks in bursts	0.2	0.4	1.3	-0.2	-0.6	-1.1	-0.2
Cd content in liver	0.1	0.1	0.2	-0.5	-0.3	0.3	-0.3
Co content in liver	3.2	3.8	8.2	-2.9	1.9	1.4	1.2
Cu content in liver	0.1	0.2	0.5	-0.2	0.7	0.3	-0.2
Fe content in liver	0.8	1.0	2.4	-1.1	0.4	0.5	1.5
K content in liver	0.8	0.7	1.0	1.0	-1.0	-1.0	-0.1
Mg content in liver	0.8	0.9	3.3	-0.5	-0.1	0.0	1.8
Mn content in liver	0.7	0.8	1.7	0.9	-1.3	-0.8	0.0
Na content in liver	0.1	0.1	0.1	0.3	0.0	-0.3	-0.2
Rb content in liver	0.9	1.1	3.1	-1.0	0.3	0.2	1.7
Se content in liver	0.7	0.8	1.4	-1.1	0.6	1.2	0.7
Sr content in liver	0.9	0.8	1.4	1.0	-0.5	-0.7	-1.2
Zn content in liver	0.6	0.7	1.3	-1.1	0.8	0.6	0.7
Bone: minimum diameter	3.8	7.3	10.4	3.2	-2.7	-2.7	-2.0
Time in familiar zone, hab. session 1	1.1	1.2	2.3	-1.0	0.7	1.1	1.5
Time in novel zone, hab. session 1	1.7	1.9	2.9	1.1	-1.2	-1.5	-1.7
Total zone transitions, hab. session 1	2.8	3.9	5.2	2.3	-2.1	-2.2	-1.0
Total locomotion distance, hab. session 1	1.7	2.5	3.6	1.7	-1.7	-1.9	-0.7
Locomotion velocity, hab. session 1	2.7	3.8	4.8	2.2	-2.1	-2.1	-1.4
Time in familiar zone, hab. session 2	0.2	0.2	0.4	-0.5	0.0	0.4	0.6
Time in novel zone, hab. session 2	0.4	0.4	1.1	0.4	-0.2	-0.5	-1.0
Total zone transitions, hab. session 2	0.8	1.0	1.6	1.0	-1.3	-1.2	0.2
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.2	-0.7	-0.3	0.7
Locomotion velocity, hab. session 2	0.2	0.3	0.5	0.3	-0.7	-0.2	0.7
Novel to familiar place preference ratio	0.6	0.8	2.0	0.5	-0.8	-1.4	-0.3
Novelty place preference	0.8	1.0	2.3	0.7	-1.0	-1.5	-0.5
Time in novel zone, NPP test	1.0	1.2	2.9	0.7	-1.1	-1.7	-0.6
Total zone transitions, NPP test	1.0	1.5	2.4	1.4	-1.5	-1.3	-0.4
Total locomotion distance, NPP test	1.4	2.0	2.9	1.5	-1.7	-1.7	-0.5
Locomotion velocity, NPP test	0.6	0.9	1.6	1.0	-1.3	-1.0	-0.0
Intraocular pressure	0.1	0.1	0.3	0.0	-0.2	-0.6	0.4
Delta distance traveled before/after self-admin	0.3	0.4	0.9	0.7	-0.1	0.3	-0.9
Delta ambulatory time before/after self-admin	0.3	0.5	1.2	-0.2	0.7	1.1	-0.4
Parametrial fat weight	1.3	3.0	3.7	1.7	-1.9	-1.8	-1.3
Pavlov. Cond. lever latency	1.1	1.4	3.2	-1.8	1.0	1.0	0.7
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	0.3	-0.5	-0.4	-0.4
Pavlov. Cond. change in total contacts	0.2	0.2	0.9	1.0	-0.1	0.2	-0.1
Pavlov. Cond. index score	1.0	1.3	2.9	1.7	-1.0	-0.8	-0.9
Pavlov. Cond. latency score	0.8	1.0	2.2	1.5	-0.9	-0.8	-0.7
Pavlov. Cond. lever contacts	1.1	1.3	3.4	1.8	-0.9	-0.8	-0.8
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	-0.6	0.5	0.5	0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.5	0.5	-0.7	-0.4	-0.6
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	3.5	1.9	-1.1	-0.8	-0.9
Pavlov. Cond. response bias	0.8	1.0	1.9	1.4	-0.9	-0.8	-0.9
Pavlov. Cond. lever latency	0.1	0.2	0.4	0.0	-0.3	-0.6	-0.3
Pavlov. Cond. magazine entry latency	0.2	0.3	0.7	0.5	0.2	0.5	-0.8
Pavlov. Cond. change in total contacts	0.2	0.5	1.2	-0.3	0.8	1.1	0.5
Pavlov. Cond. index score	0.3	0.5	1.3	-0.2	0.8	1.1	0.3
Pavlov. Cond. latency score	0.4	0.6	1.6	-0.2	0.7	1.3	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.1	0.3	0.6	0.2
Pavlov. Cond. magazine entry number	0.3	0.4	0.9	0.1	-0.7	-0.9	0.4
Pavlov. Cond. intertrial magazine entries	0.5	1.1	2.0	0.5	-1.4	-1.4	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	2.0	-0.4	1.0	1.4	0.4
Pavlov. Cond. response bias	0.1	0.1	0.4	0.6	0.1	0.2	-0.3
Time in closed arm before self-admin	0.0	0.1	0.2	0.3	0.1	0.1	0.5
Time in closed arm after self-admin	0.1	0.2	0.6	-0.3	-0.1	0.1	0.7
Time in open arm before self-admin	0.9	1.0	1.8	-0.9	1.1	1.3	0.7
Time in open arm after self-admin	0.6	0.6	1.1	-0.8	1.1	0.8	0.2
Bone: periosteal estimation	4.7	11.1	16.1	4.0	-3.3	-3.2	-2.7
Bone: periosteal perimeter	5.5	10.8	15.8	4.0	-3.6	-3.0	-2.4
Bone: post-yield work	0.5	0.8	1.7	1.3	-0.5	-0.9	-0.7
Progressive ratio test 1 active lever presses	0.2	0.4	0.8	-0.9	0.8	-0.2	0.2
Progressive ratio test 1 breakpoint	0.3	0.5	1.0	-1.0	0.9	-0.1	0.2
Progressive ratio test 1 inactive lever presses	0.2	0.6	2.0	0.2	-0.6	-1.4	-0.1
Progressive ratio test 2 active lever presses	1.1	1.5	4.0	-2.0	1.2	0.3	0.7
Progressive ratio test 2 breakpoint	0.8	1.1	3.0	-1.7	1.0	0.1	0.5
Progressive ratio test 2 inactive lever presses	0.6	2.0	5.1	-2.3	1.1	0.9	0.9
Incentive Sensitization - Responses	1.2	3.4	6.1	-2.5	1.7	1.9	0.9
Incentive Sensitization - Breakpoint	1.4	3.1	5.9	-2.4	1.6	1.7	0.9
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.4	-0.3	-0.4	0.3
Progressive ratio	2.0	5.8	7.9	2.8	-2.0	-2.0	-2.7
Food seeking constrained by brief footshock	3.8	4.8	5.9	2.4	-1.6	-2.2	-2.4
Seeking ratio, punishment vs. effort	0.4	0.8	1.3	-1.0	1.2	0.6	0.7
Retroperitoneal fat weight	1.1	4.7	6.6	2.1	-2.6	-2.5	-1.2
Reaction time number correct	0.2	0.9	1.8	-1.3	0.8	0.4	1.0
Reaction time mean minus median	0.1	0.7	1.0	0.9	-0.7	-0.8	-1.0
Reaction time mean minus median AUC	0.0	0.3	0.5	0.3	-0.5	-0.7	-0.6
Reaction time num false alarms	0.0	0.0	0.1	-0.2	0.2	0.1	-0.1
Reaction time num false alarms AUC	0.2	0.5	0.8	-0.8	0.9	0.5	0.1
Reaction time trials correct on left	0.2	0.9	1.8	-1.3	0.8	0.4	1.0
Reaction time trials on left	0.3	1.0	2.0	-1.4	0.8	0.4	1.0
Reaction time mean	0.3	0.7	1.2	1.0	-0.8	-1.1	-0.5
Reaction time mean AUC	0.2	0.4	0.8	0.7	-0.5	-0.9	-0.4
Median of all reaction times	0.3	0.4	0.9	0.7	-0.5	-1.0	-0.1
Reaction time omissions	0.3	0.5	1.1	0.1	-0.9	-1.0	-0.1
Reaction time false alarm rate	0.1	0.2	0.3	-0.4	0.6	0.5	-0.0
Reaction time premature initiation rate	2.5	3.9	7.8	2.8	-1.7	-1.1	-1.9
Reaction time premature initiations	0.7	2.1	3.9	2.0	-1.3	-0.8	-1.4
Std. dev. reaction times	0.2	0.6	0.9	0.8	-0.8	-0.9	-0.6
Reaction time trials completed	0.3	1.0	2.0	-1.4	0.8	0.4	1.0
Reaction time trials AUC	0.4	1.4	2.6	-1.6	1.0	0.7	1.2
Run reversals in cocaine runway, females	0.6	0.7	1.0	-0.9	0.7	0.6	1.0
Run reversals in cocaine runway, males	0.4	0.5	0.9	0.3	-0.9	-1.0	-0.0
Latency to leave start box in cocaine runway	2.1	2.9	5.1	1.6	-2.3	-1.7	-1.1
Latency to leave start box in cocaine runway, F	2.0	2.5	5.5	0.8	-2.3	-2.0	-0.1
Latency to leave start box in cocaine runway, M	1.9	1.8	3.6	1.7	-0.8	-0.3	-1.9
Std. dev. time between licks in bursts	0.1	0.2	0.4	0.0	-0.4	0.7	0.3
Total sessions with >9 infusions	0.3	0.4	1.3	-0.2	-0.0	-1.1	-0.6
Short access day 1 total inactive lever presses	0.0	0.1	0.1	-0.3	-0.3	-0.0	-0.1
Short access day 10 total inactive lever presses	0.0	0.2	0.7	0.4	-0.8	-0.4	-0.1
Short access day 1 total infusions	0.1	0.3	0.6	-0.6	-0.2	-0.8	0.3
Short access day 10 total infusions	0.4	0.7	1.5	-1.2	-0.3	-1.0	0.5
Short access total infusions	0.4	0.5	1.2	-0.9	0.0	-1.1	0.3
Short access day 1 locomotion	0.3	0.5	1.9	0.0	0.2	-0.2	-1.4
Short access day 10 total locomotion	0.1	0.5	1.3	-0.8	0.4	-0.1	1.2
Short access total locomotion	0.6	0.9	2.3	0.3	-0.7	-1.5	-0.9
One hour access (0.3 mA shock)	0.0	0.1	0.1	-0.4	-0.2	-0.1	0.3
Compulsive drug intake	0.3	0.5	1.1	1.1	-0.2	0.4	-0.8
One hour access (shock baseline)	0.3	0.8	1.9	-1.4	0.4	-0.3	1.0
Social response proportion	2.6	3.3	5.8	1.6	-2.4	-2.0	-1.0
Social responses	7.3	9.6	13.9	2.8	-3.7	-3.6	-1.7
Social time	1.6	2.5	3.5	1.3	-1.9	-1.7	-1.4
Soleus weight	0.3	0.9	1.7	0.9	-1.3	-1.1	-0.2
Bone: stiffness	3.2	5.8	9.2	3.0	-2.1	-2.3	-2.1
Tibialis anterior weight	0.4	1.3	3.2	1.8	0.1	-0.3	-1.4
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.7	-0.2	0.8	0.1	0.2
Time to tail flick, vehicle, after self-admin	0.4	0.9	2.2	0.1	-0.9	-1.5	-0.7
Time to tail flick, test, before self-admin	0.2	0.2	0.5	-0.1	-0.7	-0.5	-0.1
Time to tail flick, test, after self-admin	0.8	0.9	2.8	0.6	-1.7	-0.6	-0.0
Delta time to tail flick, vehicle, before/after SA	3.6	3.9	5.8	1.3	-2.3	-2.4	-1.7
Delta time to tail flick, test, before/after SA	0.9	1.1	1.7	1.3	-1.2	-0.9	-0.7
Tibia length	0.2	0.6	1.2	1.1	-0.5	-0.3	-0.8
Ambulatory time before self-admin	0.1	0.2	0.4	0.4	-0.0	-0.6	0.3
Ambulatory time after self-admin	0.1	0.1	0.2	0.1	0.5	0.3	0.3
Bone: tissue strength	0.2	0.2	0.4	-0.3	0.1	0.4	0.6
Total heroin consumption	0.3	0.4	0.6	-0.8	0.5	0.1	0.7
Bone: trabecular number	0.2	0.4	0.6	0.2	-0.7	-0.7	0.6
Bone: trabecular spacing	0.3	0.5	0.7	0.5	-0.8	-0.5	-0.8
Bone: trabecular thickness	0.1	0.1	0.3	0.5	-0.3	-0.3	0.3
Bone: trabecular tissue density	2.2	3.8	7.1	2.7	-1.2	-1.9	-1.8
Water consumed over 24 hours	0.7	1.4	3.4	0.6	-1.9	-1.2	-0.3
Number of responses in last shaping day	1.1	1.4	1.8	1.3	-0.7	-1.3	-1.3