LOC134483301

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC134483301	0.14	0.08	1.6e-14	0.14	0.15	0.14	0.14	1.5e-12	3.3e-14	4.3e-13	5.3e-13
2	NAcc	gene expression	LOC134483301	0.02	0.01	4.7e-03	0.01	0.01	0.01	0.01	3.8e-02	3.3e-02	8.0e-03	1.9e-02
3	Liver	gene expression	LOC134483301	0.46	0.12	0.0e+00	0.44	0.44	0.43	0.45	8.9e-53	2.9e-53	1.2e-51	4.0e-55
4	Liver	intron excision ratio	chr19_35582034_35587448	0.05	0.03	2.0e-08	0.07	0.06	0.06	0.06	5.0e-08	7.1e-07	4.2e-07	2.8e-07
5	PL	gene expression	LOC134483301	0.04	0.03	2.7e-04	0.02	0.03	0.02	0.02	1.4e-03	3.6e-04	5.4e-03	1.1e-03
6	Liver	intron excision ratio	chr19_35582023_35583017	0.02	0.01	8.3e-03	0.01	0	-0	0	4.7e-02	7.6e-02	4.8e-01	2.0e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	2.4	4.4	5.5	-2.2	2.1	2.0	-2.4	-1.9	1.9
Area under the delay curve	0.1	0.1	0.3	-0.2	-0.2	0.4	-0.5	0.1	-0.1
BMI with tail	1.5	5.2	7.1	2.1	-2.4	-2.0	1.8	2.7	-2.6
BMI without tail	0.0	0.1	0.1	-0.2	-0.1	0.4	-0.1	0.3	-0.2
Body weight	0.5	2.4	3.4	1.6	-1.2	-1.6	1.8	1.4	-1.6
Weight adjusted by age	1.0	2.8	4.7	1.5	-1.5	-1.5	1.3	2.2	-1.9
Bone surface	2.0	3.9	6.2	-2.1	2.0	1.9	-2.5	-1.7	1.7
Bone volume	3.5	6.9	9.3	-2.8	2.8	2.4	-3.0	-2.3	2.4
Breakpoint value in progressive ratio session	0.5	1.0	2.2	1.3	-0.5	-1.3	1.5	0.0	-0.2
Number of licking bursts	0.1	0.3	0.6	-0.3	0.3	0.5	-0.4	-0.8	0.6
Context. condit. distance diff. score	3.6	4.4	8.1	2.4	-2.9	-1.9	1.6	1.7	-1.9
Locomotion velocity, session 1	0.2	0.2	0.4	-0.2	0.6	0.0	-0.1	-0.7	0.6
Locomotion distance, session 1	0.4	0.5	0.9	0.9	-0.9	-0.9	0.4	0.1	-0.5
Locomotion velocity, session 2	0.0	0.1	0.1	0.3	-0.3	-0.2	0.1	-0.1	-0.2
Locomotion distance, session 2	0.8	1.2	2.0	1.4	-1.2	-1.3	0.7	0.6	-1.0
Locomotion velocity, session 3	1.0	1.2	1.7	1.2	-1.1	-1.1	0.5	1.3	-1.2
Locomotion distance, session 3	0.2	0.2	0.5	-0.3	-0.2	0.7	-0.7	-0.2	0.1
Stereotopy head waving bouts, day 3	0.2	0.2	0.6	0.1	-0.6	0.0	-0.7	0.5	-0.5
Stereotopy head waving duration, day 3	0.4	0.5	0.9	0.7	-1.0	-0.6	0.0	0.9	-0.9
Locomotion velocity, session 7	0.7	0.7	2.0	1.0	-1.4	-0.6	0.2	0.6	-0.8
Locomotion distance, session 7	0.1	0.1	0.3	0.4	-0.4	-0.2	-0.0	-0.5	0.3
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	-0.3	-0.2	0.6	-0.7	0.3	-0.2
Stereotopy head waving duration, day 7	1.2	1.5	2.3	-1.4	1.0	1.5	-1.5	-0.7	0.9
Locomotion velocity, session 8	2.2	2.7	4.4	2.1	-1.9	-1.9	1.3	1.0	-1.2
Locomotion distance, session 8	2.2	3.2	6.6	2.3	-2.6	-1.8	1.0	1.0	-1.5
Degree of sensitization distance	0.3	0.3	0.8	0.7	-0.3	-0.9	0.8	-0.0	-0.1
Degree of sensitization stereotypy	0.1	0.1	0.3	-0.4	0.0	0.5	-0.5	0.3	-0.0
Conditioned locomotion	0.0	0.1	0.2	-0.2	0.2	-0.0	-0.4	-0.0	0.2
Cocaine response after cond. corrected	3.7	5.5	6.7	2.6	-2.3	-2.5	2.6	1.8	-2.1
Cocaine response after cond. not corrected	3.2	4.7	7.1	2.4	-1.9	-2.4	2.7	1.6	-1.9
Cocaine response before conditioning	2.1	2.6	3.6	-1.7	1.9	1.7	-1.0	-1.6	1.6
Saline control response	0.6	0.8	2.9	0.0	0.2	0.5	-0.8	-1.7	1.1
Bone: connectivity density	2.7	4.3	6.5	-2.2	1.7	2.2	-2.6	-1.9	1.8
Bone: cortical apparent density	0.2	0.3	1.0	-0.5	-0.2	1.0	-0.8	-0.2	0.2
Bone: cortical area	0.2	0.3	0.5	-0.3	0.6	0.3	-0.5	-0.7	0.6
Bone: cortical porosity	0.1	0.1	0.3	0.5	-0.2	-0.5	0.1	0.1	-0.3
Bone: cortical porosity	0.1	0.1	0.3	-0.1	0.3	0.2	-0.5	-0.5	0.3
Bone: cortical thickness	0.0	0.1	0.2	-0.2	0.3	0.2	-0.4	-0.2	0.2
Bone: cortical thickness	0.4	0.5	1.1	0.9	-0.6	-0.6	1.0	-0.0	-0.2
Bone: cortical tissue density	0.2	0.3	0.9	-0.5	-0.3	0.9	-0.8	-0.2	0.1
Condit. Reinf. active minus inactive responses	0.4	0.5	1.2	0.2	-1.1	0.5	-1.0	0.0	-0.4
Condit. Reinf. active-inactive response ratio	1.2	1.3	3.3	1.4	-1.8	-0.8	0.5	0.7	-1.2
Condit. Reinf. active responses	1.4	1.7	3.7	-1.1	0.5	1.8	-1.9	-1.1	0.9
Condit. Reinf. inactive responses	6.6	8.6	9.8	-3.0	3.1	3.1	-2.8	-2.6	2.9
Incentive salience index mean	1.7	2.2	4.9	-1.2	0.4	1.9	-2.2	-1.4	1.0
Condit. Reinf. lever presses	3.5	5.2	7.2	-2.2	1.8	2.6	-2.7	-2.2	2.1
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	0.6	-0.5	-0.7	0.4	0.6	-0.5
Condit. Reinf. active-inactive response ratio	0.4	0.6	1.1	0.5	0.0	-0.9	0.8	1.0	-0.8
Condit. Reinf. active responses	0.1	0.2	0.4	0.6	-0.3	-0.6	0.5	0.3	-0.2
Condit. Reinf. inactive responses	0.3	0.5	1.0	1.0	-0.9	-0.8	0.6	0.2	-0.3
Condit. Reinf. lever presses	0.4	0.6	0.8	0.9	-0.9	-0.8	0.5	0.7	-0.8
Condit. Reinf. lever reinforcers received	0.4	0.5	0.8	0.8	-0.5	-0.9	0.7	0.6	-0.5
Conditioned reinforcement - actives	0.0	0.1	0.4	0.6	-0.4	-0.4	0.3	-0.1	0.1
Conditioned reinforcement - inactives	0.2	0.4	1.1	1.0	-1.0	-0.5	0.4	0.2	-0.4
Conditioned locomotion	0.0	0.0	0.1	-0.1	0.3	0.1	0.0	-0.3	0.3
Patch foraging indifference point 0 sec	0.2	0.5	1.2	0.6	-1.1	-0.3	-0.6	0.6	-0.7
Patch foraging indifference point AUC	0.2	0.5	0.8	-0.6	0.9	0.3	-0.8	-0.8	0.9
Delay disc. indifference point, 0s delay	0.7	0.8	1.4	-0.8	1.1	0.6	-0.3	-1.2	1.2
Delay disc. indifference point, 16s delay	0.4	0.5	0.8	0.6	-0.6	-0.5	0.7	0.9	-0.9
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	-0.6	0.3	0.5	-0.6	0.3	-0.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.2	0.2	0.5	-0.4	-0.2	0.3
Delay disc. indifference point, 4s delay	0.3	0.3	1.0	-0.4	-0.2	0.8	-1.0	-0.2	0.2
Delay disc. indifference point, 8s delay	0.1	0.2	0.5	0.4	-0.7	-0.0	-0.3	0.5	-0.6
Indifference point function ln k	0.2	0.5	1.0	0.3	-1.0	0.0	0.1	0.9	-1.0
Indifference point function log k	0.2	0.5	1.0	0.3	-1.0	0.0	0.1	0.9	-1.0
Patch foraging total patch changes 0 sec	0.2	0.7	1.8	0.8	-1.3	-0.6	-0.3	0.8	-0.9
Patch foraging total patch changes 12 sec	0.4	0.5	1.1	-0.2	-0.0	0.6	-1.0	-1.1	0.6
Patch foraging total patch changes 18 sec	0.6	1.4	2.9	-0.7	0.7	0.8	-1.7	-1.5	1.2
Patch foraging total patch changes 24 sec	0.4	1.3	3.0	-0.5	0.5	1.0	-1.7	-1.5	1.0
Patch foraging total patch changes 6 sec	0.1	0.2	0.6	-0.2	0.1	0.5	-0.8	-0.6	0.4
Patch foraging time to switch 0 sec	0.0	0.1	0.2	0.1	-0.2	0.1	0.4	-0.3	0.1
Patch foraging water rate 0 sec	0.0	0.1	0.2	0.1	0.3	-0.4	-0.1	0.1	0.0
Patch foraging water rate 12 sec	0.6	2.5	3.7	-1.7	1.3	1.9	-1.8	-1.3	1.3
Patch foraging water rate 18 sec	3.2	7.2	10.1	-3.2	2.9	3.2	-2.5	-2.2	2.1
Patch foraging water rate 24 sec	0.7	0.9	2.0	-1.1	0.6	1.2	-1.4	-0.5	0.4
Patch foraging water rate 6 sec	3.1	4.5	6.1	-1.9	2.3	1.9	-2.0	-2.5	2.2
Seeking ratio, delayed vs. immediate footshock	2.7	3.8	6.2	1.9	-2.5	-1.6	0.9	2.1	-2.3
Distance traveled before self-admin	1.1	2.3	3.7	1.4	-1.2	-1.6	1.3	1.9	-1.6
Distance traveled after self-admin	0.1	0.1	0.3	-0.4	0.6	0.2	-0.2	0.4	-0.2
Extensor digitorum longus weight	0.1	0.5	1.9	-0.0	0.8	-0.3	1.4	0.4	-0.1
Bone: elastic displacement	0.1	0.1	0.3	-0.3	0.1	0.3	-0.6	-0.1	0.1
Bone: elastic work	0.0	0.0	0.1	-0.2	0.4	0.1	-0.1	-0.1	0.1
Bone: endosteal estimation	0.3	0.7	1.0	1.0	-0.7	-1.0	1.0	0.4	-0.7
Bone: endosteal perimeter	0.3	0.8	1.4	1.2	-1.0	-1.1	0.8	0.4	-0.7
Epididymis fat weight	0.3	1.7	2.1	1.4	-1.3	-1.4	1.2	1.1	-1.3
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	0.2	-0.5	-0.1	0.2	0.5	-0.4
Delta time in open arm before/after self-admin	0.3	0.3	0.8	0.4	0.6	-0.5	0.9	-0.4	0.5
Diff in mean of infusions in LGA sessions	0.3	0.5	1.0	1.0	-1.0	-0.8	0.7	0.3	-0.5
Delay discount exponential model param	0.1	0.2	0.6	0.4	0.1	-0.6	0.8	-0.0	0.0
Extinction: sum of active levers before priming	2.3	3.5	4.8	1.6	-2.1	-1.4	1.5	2.2	-2.2
Active lever presses in extinction session 6	0.3	0.3	0.6	-0.8	0.2	0.7	-0.7	0.1	-0.1
Bone: final force	0.9	1.5	3.3	-1.1	1.8	0.9	-0.6	-1.2	1.3
Bone: final moment	0.6	0.9	2.2	-0.9	1.5	0.7	-0.4	-1.0	1.0
Food consumed during 24 hour testing period	1.8	3.6	7.2	-1.4	2.1	1.5	-1.0	-2.7	2.3
Glucose	0.3	0.5	1.0	-0.4	1.0	0.2	-0.5	-1.0	0.9
Heart weight	0.3	0.5	1.5	0.4	-1.2	-0.1	-0.5	0.5	-0.8
Delay discount hyperbolic model param	0.2	0.3	0.8	0.4	0.1	-0.8	0.9	0.1	-0.0
Intermittent access intake day 1-15 change	0.8	4.2	6.7	-1.6	2.0	1.6	-1.7	-2.6	2.5
Intermittent access intake escalation	0.6	3.1	5.0	-1.4	1.7	1.4	-1.5	-2.2	2.1
Intermittent access intake escalation 2	1.5	2.5	4.7	-1.1	1.1	1.4	-1.5	-2.2	1.9
Intermitt. access day 1 inactive lever presses	0.0	0.3	1.0	-0.3	-0.5	0.8	-1.0	-0.2	0.1
Intermitt. access day 15 inactive lever presses	0.2	1.3	2.4	1.3	-1.6	-1.0	0.6	1.0	-1.2
Intermitt. access escalation Index	0.0	0.1	0.1	-0.2	0.0	0.3	-0.4	0.2	0.1
Intermittent access day 1 total infusions	1.0	3.0	3.7	1.9	-1.3	-1.9	1.7	1.8	-1.6
Intermittent access day 15 total infusions	0.1	0.2	0.6	0.6	-0.1	-0.8	0.6	0.3	-0.2
Intermittent access terminal intake (last 3 days)	0.3	0.6	1.1	1.1	-0.5	-1.0	0.8	0.5	-0.4
Intermittent access total infusions	0.5	0.6	1.3	1.0	-0.4	-1.1	1.1	0.5	-0.4
Intermittent access day 1 locomotion	0.1	0.1	0.4	-0.3	0.6	0.0	0.2	0.4	-0.0
Intermittent access day 15 total locomotion	0.2	0.6	1.5	0.5	0.2	-1.0	1.2	0.9	-0.5
Intermittent access total locomotion	0.8	0.9	2.5	0.9	0.1	-1.3	1.6	0.7	-0.4
Intermittent access standard deviation	0.2	1.2	2.2	-0.9	0.8	1.0	-1.2	-1.5	1.1
Left kidney weight	0.4	3.1	4.1	-1.7	2.0	1.8	-1.2	-2.0	1.8
Right kidney weight	0.0	0.3	1.0	-0.1	0.6	0.3	0.2	-1.0	0.6
Cocaine induced anxiety	0.2	0.7	2.5	1.0	-1.6	-0.3	0.1	0.3	-0.6
Post-drug Anxiety	0.6	0.7	1.7	1.0	-1.3	-0.5	0.3	0.5	-0.9
Baseline Anxiety	0.1	0.1	0.7	-0.2	0.9	-0.2	0.2	0.0	0.0
Tail length	0.6	3.5	5.2	-1.8	2.3	1.6	-1.1	-2.2	2.0
Length with tail	0.1	0.3	0.7	0.0	0.8	-0.1	0.7	-0.7	0.3
Length without tail	0.5	2.6	4.0	1.8	-1.1	-1.9	2.0	1.1	-1.4
Times rat made contact with spout	0.5	0.6	0.8	-0.8	0.8	0.9	-0.8	-0.6	0.6
Lifetime Intake	0.5	0.6	1.1	1.0	-0.4	-1.0	1.0	0.3	-0.2
Liver weight, left	0.1	0.1	0.3	0.4	0.0	-0.2	0.4	-0.5	0.2
Liver weight, right	0.0	0.0	0.1	0.3	0.1	-0.2	0.4	0.0	-0.2
Locomotor activity	0.2	0.2	0.5	0.6	0.0	-0.7	0.5	0.4	-0.4
Locomotor testing distance	0.1	0.4	0.6	0.7	-0.3	-0.8	0.8	0.5	-0.4
Locomotor testing rearing	0.1	0.3	1.2	0.1	-0.0	0.4	-0.5	-1.1	0.6
Locomotion in novel chamber	0.7	1.0	1.4	1.2	-1.0	-1.1	1.0	0.6	-1.0
Locomotion in novel chamber post-restriction	0.3	1.0	1.5	-1.2	1.0	1.0	-1.0	-0.9	0.9
Fecal boli incidents, locomotor time 1	0.1	0.2	0.9	0.1	0.3	-0.0	0.1	-0.9	0.7
Change in fecal boli incidents, locomotor task	1.3	1.4	3.5	-1.0	0.4	1.5	-1.9	-0.6	0.8
Time >=10cm from walls, locomotor time 1	0.4	0.5	1.0	-0.6	1.0	0.8	-0.5	-0.6	0.8
Bouts of movement, locomotor time 1	0.6	0.8	1.4	-1.2	0.5	0.9	-0.9	-0.8	0.8
Total resting periods, locomotor time 1	0.5	0.6	1.2	-1.1	0.2	0.9	-1.1	-0.6	0.5
Rest time, locomotor task time 1	0.4	0.7	1.7	-1.0	0.4	0.8	-1.3	-0.5	0.5
Distance moved, locomotor task time 1	0.5	1.5	4.3	1.2	-0.7	-1.1	2.1	0.9	-0.6
Vertical activity count, locomotor time 1	0.1	0.6	1.9	0.6	0.6	-0.5	1.4	-0.5	0.7
Time >=10cm from walls, locomotor time 2	0.2	0.5	1.0	0.6	-0.1	-0.8	0.9	1.0	-0.6
Bouts of movement, locomotor time 2	0.1	0.3	0.7	-0.8	0.1	0.8	-0.7	0.1	0.2
Total resting periods, locomotor time 2	0.1	0.4	0.8	-0.8	0.2	0.9	-0.9	-0.2	0.4
Rest time, locomotor task time 2	0.2	0.3	1.1	-0.4	-0.2	0.4	-1.0	-0.4	0.2
Distance moved, locomotor task time 2	2.2	2.9	6.2	1.6	-1.1	-1.6	2.5	1.7	-1.4
Vertical activity count, locomotor time 2	0.3	0.7	2.0	1.1	0.1	-0.7	1.4	-0.4	0.2
Light reinforcement 1	4.3	19.4	27.8	-3.8	4.7	3.9	-3.6	-5.3	4.9
Light reinforcement 2	4.1	9.4	13.8	-2.8	3.7	2.6	-1.6	-3.6	3.5
Bone: marrow area	0.3	0.7	1.1	1.1	-0.7	-1.0	1.0	0.4	-0.7
Bone: maximum diameter	0.1	0.2	0.4	0.6	-0.7	-0.5	0.2	0.4	-0.5
Bone: maximum force	0.1	0.1	0.4	-0.1	0.7	-0.1	0.1	-0.3	0.2
Bone: maximum moment	0.0	0.1	0.1	0.1	0.3	-0.3	0.3	-0.1	-0.0
Mean time between licks in bursts	0.0	0.3	0.8	-0.2	-0.3	0.9	-0.6	-0.5	0.2
Mean num. licks in bursts	0.1	0.1	0.3	-0.5	0.3	0.4	-0.5	0.3	-0.1
Cd content in liver	3.4	3.8	6.5	2.2	-2.6	-1.7	1.5	1.5	-2.0
Co content in liver	0.8	0.9	2.1	0.7	-1.5	-0.4	0.2	1.1	-1.2
Cu content in liver	0.0	0.0	0.1	0.2	0.0	-0.1	0.3	0.1	-0.1
Fe content in liver	3.3	4.0	7.0	-2.6	2.6	1.9	-1.8	-1.1	1.6
K content in liver	0.6	0.6	1.2	0.6	-0.3	-0.7	0.5	1.1	-1.0
Mg content in liver	0.4	0.4	0.9	0.6	-0.6	-0.6	0.1	0.9	-0.8
Mn content in liver	1.4	1.6	2.3	1.5	-1.5	-1.4	0.9	1.1	-1.1
Na content in liver	0.2	0.2	0.7	-0.5	0.9	0.1	0.0	0.1	0.1
Rb content in liver	1.3	1.5	2.7	-1.2	1.1	1.3	-1.7	-1.0	1.0
Se content in liver	2.0	2.3	4.7	-1.8	2.2	1.3	-1.2	-1.1	1.4
Sr content in liver	0.6	0.5	0.5	0.7	-0.7	-0.7	0.7	0.7	-0.7
Zn content in liver	2.1	2.4	2.7	1.7	-1.5	-1.4	1.5	1.6	-1.6
Bone: minimum diameter	0.4	0.7	1.2	-0.7	1.1	0.5	-0.5	-1.1	1.0
Time in familiar zone, hab. session 1	1.2	1.3	2.4	-1.1	0.7	1.3	-1.5	-1.1	1.0
Time in novel zone, hab. session 1	0.4	0.5	1.0	0.4	-0.3	-0.6	0.8	1.0	-0.8
Total zone transitions, hab. session 1	0.3	0.5	0.7	0.8	-0.7	-0.8	0.4	0.7	-0.6
Total locomotion distance, hab. session 1	0.9	1.2	1.9	1.2	-1.1	-1.4	0.7	1.1	-1.0
Locomotion velocity, hab. session 1	0.9	1.2	2.1	1.3	-1.1	-1.4	0.8	1.0	-0.9
Time in familiar zone, hab. session 2	1.5	1.7	2.8	-1.0	0.9	1.3	-1.4	-1.7	1.4
Time in novel zone, hab. session 2	4.2	4.5	6.2	1.9	-1.7	-2.1	2.3	2.5	-2.2
Total zone transitions, hab. session 2	0.2	0.3	1.2	-0.1	-0.1	0.3	-1.1	-0.5	0.3
Total locomotion distance, hab. session 2	0.2	0.3	0.7	0.8	-0.5	-0.9	0.2	0.3	-0.3
Locomotion velocity, hab. session 2	0.1	0.2	0.5	0.6	-0.2	-0.7	0.1	0.1	-0.1
Novel to familiar place preference ratio	0.8	1.1	2.0	0.8	-1.0	-0.9	0.6	1.3	-1.4
Novelty place preference	0.8	1.1	1.9	0.8	-0.9	-1.0	0.8	1.3	-1.4
Time in novel zone, NPP test	0.6	0.7	1.4	0.5	-0.6	-0.7	0.5	1.2	-1.2
Total zone transitions, NPP test	0.1	0.2	0.5	0.7	-0.5	-0.6	0.1	-0.1	-0.1
Total locomotion distance, NPP test	0.1	0.1	0.2	0.4	-0.2	-0.5	0.0	0.3	-0.2
Locomotion velocity, NPP test	0.1	0.2	0.5	0.6	-0.3	-0.7	0.1	0.2	-0.2
Intraocular pressure	3.0	4.8	7.0	2.0	-2.6	-1.9	1.5	2.5	-2.4
Delta distance traveled before/after self-admin	2.5	2.8	3.6	-1.7	1.9	1.7	-1.4	-1.7	1.6
Delta ambulatory time before/after self-admin	2.7	4.6	5.5	-2.1	2.2	2.3	-1.9	-2.3	2.1
Parametrial fat weight	0.3	0.7	1.2	1.1	-1.0	-0.9	0.8	-0.1	-0.6
Pavlov. Cond. lever latency	0.2	0.3	0.4	0.6	-0.6	-0.6	0.6	0.2	-0.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	-0.6	0.2	0.4	-0.8	0.2	0.0
Pavlov. Cond. change in total contacts	1.8	1.9	2.6	-1.6	1.6	1.5	-1.4	-1.1	1.1
Pavlov. Cond. index score	0.1	0.1	0.3	-0.4	0.1	0.4	-0.5	0.2	-0.1
Pavlov. Cond. latency score	0.0	0.1	0.2	-0.2	-0.1	0.2	-0.5	0.2	-0.2
Pavlov. Cond. lever contacts	0.2	0.2	0.4	-0.7	0.6	0.5	-0.5	-0.1	0.2
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.6	-0.4	-0.5	0.5	-0.2	0.0
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.1	-0.2	0.1	-0.2	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.2	-0.1	0.1	-0.3	0.5	-0.3
Pavlov. Cond. response bias	0.6	0.8	1.5	-1.2	1.0	1.1	-0.9	-0.1	0.4
Pavlov. Cond. lever latency	0.4	0.6	0.8	0.7	-0.6	-0.9	0.8	0.9	-0.9
Pavlov. Cond. magazine entry latency	0.0	0.0	0.2	0.1	-0.2	0.1	-0.0	-0.4	0.1
Pavlov. Cond. change in total contacts	0.1	0.3	0.8	-0.6	0.2	0.7	-0.9	-0.4	0.4
Pavlov. Cond. index score	0.1	0.1	0.2	-0.3	0.1	0.5	-0.4	-0.5	0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.3	0.1	0.4	-0.3	-0.4	0.3
Pavlov. Cond. lever contacts	0.8	1.2	1.6	-0.9	0.9	1.2	-1.1	-1.3	1.2
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.2	0.2	0.2	-0.2	0.0	0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.9	1.3	-0.7	1.0	0.8	-0.8	-1.2	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.3	0.1	0.5	-0.3	-0.5	0.3
Pavlov. Cond. response bias	0.3	0.4	0.6	-0.5	0.5	0.6	-0.6	-0.7	0.7
Time in closed arm before self-admin	3.6	6.3	7.7	-2.8	2.2	2.6	-2.7	-2.4	2.3
Time in closed arm after self-admin	2.7	3.0	4.6	-2.2	1.4	2.0	-1.9	-1.4	1.4
Time in open arm before self-admin	1.7	2.1	2.9	1.6	-1.7	-1.3	0.8	1.3	-1.6
Time in open arm after self-admin	2.2	2.4	3.5	1.9	-1.0	-1.8	1.8	1.4	-1.3
Bone: periosteal estimation	0.0	0.1	0.1	0.4	0.1	-0.3	0.3	-0.3	0.0
Bone: periosteal perimeter	0.1	0.2	0.5	0.7	-0.6	-0.4	0.1	-0.1	-0.2
Bone: post-yield work	0.3	0.5	0.8	0.8	-0.5	-0.9	0.9	0.4	-0.6
Progressive ratio test 1 active lever presses	0.4	0.7	1.7	0.8	0.2	-1.1	1.3	0.6	-0.2
Progressive ratio test 1 breakpoint	0.3	0.6	1.4	0.7	0.2	-1.0	1.2	0.6	-0.2
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.5	-0.1	-0.5	0.4	0.3	0.0
Progressive ratio test 2 active lever presses	0.7	1.0	2.2	1.1	-0.5	-1.3	1.5	0.7	-0.5
Progressive ratio test 2 breakpoint	0.9	1.1	2.3	1.1	-0.6	-1.3	1.5	0.8	-0.6
Progressive ratio test 2 inactive lever presses	0.8	2.6	3.4	1.8	-1.6	-1.8	1.7	1.4	-1.3
Incentive Sensitization - Responses	0.2	0.7	1.3	1.0	-0.8	-0.9	1.2	0.4	-0.3
Incentive Sensitization - Breakpoint	0.2	0.6	1.2	0.9	-0.7	-0.9	1.1	0.3	-0.2
Sum of active levers in priming session hrs 5-6	1.0	0.9	1.3	1.1	-0.8	-1.0	1.2	0.8	-0.8
Progressive ratio	0.0	0.1	0.3	-0.3	0.6	0.1	0.1	-0.3	0.6
Food seeking constrained by brief footshock	2.0	2.5	3.1	-1.6	1.5	1.5	-1.5	-1.8	1.7
Seeking ratio, punishment vs. effort	0.4	0.9	1.4	-0.9	0.9	0.8	-0.9	-1.2	0.9
Retroperitoneal fat weight	1.0	4.5	7.0	2.6	-2.5	-2.4	2.1	1.1	-1.7
Reaction time number correct	0.1	0.2	0.5	0.3	-0.6	-0.1	-0.1	0.7	-0.5
Reaction time mean minus median	0.2	1.3	1.9	1.0	-0.6	-1.1	1.4	1.3	-1.3
Reaction time mean minus median AUC	0.3	2.0	2.6	1.3	-1.0	-1.4	1.4	1.6	-1.6
Reaction time num false alarms	3.6	6.1	9.6	2.7	-3.1	-2.2	1.7	2.2	-2.6
Reaction time num false alarms AUC	1.8	4.1	7.4	2.2	-2.7	-1.7	1.2	1.9	-2.2
Reaction time trials correct on left	0.1	0.2	0.5	0.3	-0.6	-0.1	-0.1	0.7	-0.5
Reaction time trials on left	0.1	0.3	0.7	0.4	-0.7	-0.2	0.0	0.8	-0.6
Reaction time mean	2.3	5.1	7.6	1.9	-1.9	-2.0	2.2	2.5	-2.8
Reaction time mean AUC	2.1	5.2	7.9	2.0	-2.0	-2.1	2.2	2.5	-2.8
Median of all reaction times	2.8	4.3	7.2	1.7	-1.9	-1.8	1.8	2.4	-2.7
Reaction time omissions	3.1	5.1	7.6	2.2	-2.0	-2.2	2.7	2.1	-2.2
Reaction time false alarm rate	1.6	2.2	3.9	1.6	-2.0	-1.3	1.0	1.2	-1.6
Reaction time premature initiation rate	2.2	3.4	7.4	-1.3	1.3	1.8	-1.5	-2.7	2.1
Reaction time premature initiations	0.6	1.7	3.9	-0.8	0.7	1.4	-1.2	-2.0	1.5
Std. dev. reaction times	0.8	2.6	3.6	1.5	-1.2	-1.6	1.9	1.8	-1.8
Reaction time trials completed	0.1	0.3	0.7	0.4	-0.7	-0.2	0.0	0.8	-0.6
Reaction time trials AUC	0.1	0.3	0.8	0.5	-0.7	-0.3	0.1	0.9	-0.6
Run reversals in cocaine runway, females	2.4	2.7	5.4	1.7	-0.7	-2.1	2.3	1.4	-1.1
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.0	-0.2	-0.1	0.2	0.6	-0.3
Latency to leave start box in cocaine runway	1.3	1.8	2.5	1.5	-1.1	-1.6	1.6	1.3	-1.0
Latency to leave start box in cocaine runway, F	1.7	2.1	3.2	1.2	-0.9	-1.6	1.6	1.8	-1.5
Latency to leave start box in cocaine runway, M	0.2	0.2	0.6	0.8	-0.5	-0.4	0.4	-0.4	0.3
Std. dev. time between licks in bursts	0.4	0.7	1.3	-0.7	0.6	1.2	-0.9	-1.0	0.8
Total sessions with >9 infusions	0.1	0.1	0.4	0.2	0.2	-0.3	0.6	0.3	0.2
Short access day 1 total inactive lever presses	0.2	0.3	0.9	0.6	0.3	-0.8	1.0	0.2	0.2
Short access day 10 total inactive lever presses	0.1	0.9	1.6	-0.8	0.1	1.3	-1.1	-1.1	0.5
Short access day 1 total infusions	0.3	0.6	1.0	0.8	-0.6	-0.9	0.8	1.0	-0.5
Short access day 10 total infusions	0.1	0.2	0.4	0.6	-0.1	-0.6	0.6	0.2	0.1
Short access total infusions	0.3	0.4	0.8	0.9	-0.3	-0.8	0.9	0.4	-0.1
Short access day 1 locomotion	1.9	3.2	4.8	1.7	-1.4	-2.0	2.2	2.0	-1.4
Short access day 10 total locomotion	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.1	0.2	-0.2
Short access total locomotion	0.5	0.7	1.3	0.7	-0.7	-0.9	1.1	0.9	-0.6
One hour access (0.3 mA shock)	1.8	2.2	3.6	1.9	-1.7	-1.6	1.5	0.8	-1.0
Compulsive drug intake	0.5	0.7	1.6	-0.9	-0.1	1.2	-1.3	-0.4	0.3
One hour access (shock baseline)	0.9	2.3	3.6	1.9	-1.3	-1.9	1.7	0.9	-1.0
Social response proportion	0.5	0.6	1.1	0.4	-0.4	-0.7	1.1	0.8	-0.9
Social responses	0.4	0.5	1.5	0.8	-1.2	-0.4	0.3	0.2	-0.8
Social time	0.8	1.3	2.1	-1.3	1.0	1.4	-1.5	-1.0	0.6
Soleus weight	0.0	0.0	0.1	0.1	-0.3	0.0	-0.1	-0.2	0.1
Bone: stiffness	0.2	0.3	0.7	0.4	0.4	-0.8	0.8	0.1	-0.2
Tibialis anterior weight	0.3	1.2	1.7	0.9	-1.0	-0.7	1.3	1.2	-1.3
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.1	-0.3	-0.2	0.1	0.2	-0.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.5	0.0	0.1	-0.2	-0.0	-0.5	0.7
Time to tail flick, test, before self-admin	2.4	2.8	3.9	1.7	-1.4	-1.9	2.0	1.6	-1.4
Time to tail flick, test, after self-admin	1.4	1.5	2.3	-1.5	1.5	1.0	-0.9	-0.8	1.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.1	0.2	-0.1	-0.1	-0.5	0.5
Delta time to tail flick, test, before/after SA	3.7	4.5	6.6	-2.6	2.3	2.2	-2.3	-1.5	1.8
Tibia length	0.1	0.2	0.6	-0.1	0.8	-0.3	0.5	0.5	-0.1
Ambulatory time before self-admin	1.2	3.7	5.2	1.8	-1.6	-2.1	1.7	2.3	-2.0
Ambulatory time after self-admin	0.2	0.4	1.0	-0.7	1.0	0.5	-0.4	-0.2	0.4
Bone: tissue strength	0.0	0.0	0.1	0.1	-0.1	-0.2	0.1	0.3	-0.2
Total heroin consumption	1.0	1.2	2.1	1.4	-1.0	-1.2	1.1	0.7	-0.9
Bone: trabecular number	3.0	5.7	7.1	-2.7	2.3	2.6	-2.7	-1.9	2.1
Bone: trabecular spacing	2.6	3.7	4.4	2.1	-1.9	-2.0	2.0	1.8	-1.8
Bone: trabecular thickness	3.4	4.7	7.7	-2.3	2.8	2.0	-1.8	-1.9	2.2
Bone: trabecular tissue density	1.3	2.2	3.0	1.6	-1.1	-1.7	1.4	1.4	-1.6
Water consumed over 24 hours	1.1	2.1	2.7	-1.4	1.6	1.4	-1.1	-1.6	1.5
Number of responses in last shaping day	0.8	1.1	2.1	0.9	-1.4	-0.8	0.5	1.1	-1.1