Hub : Genes

LOC134483298

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	LOC134483298	0.08	0.05	8.9e-08	0.1	0.08	0.09	0.1	1.6e-08	4.6e-07	8.0e-08	2.7e-08
2	LHb	gene expression	LOC134483298	0.15	0.1	5.3e-03	0.01	-0	0.01	0.01	1.5e-01	3.7e-01	1.6e-01	1.9e-01
3	Adipose	gene expression	LOC134483298	0.05	0.03	1.2e-06	0.05	0.02	0.05	-0	1.5e-06	2.9e-03	6.8e-06	9.7e-01
4	NAcc	gene expression	LOC134483298	0.03	0.02	4.9e-05	0.03	0.03	0.02	0.02	6.0e-05	7.8e-05	1.6e-04	1.4e-04
5	PL	gene expression	LOC134483298	0.02	0.01	9.5e-03	0.01	0.01	0.01	0.01	1.0e-02	1.0e-02	1.8e-02	1.7e-02
6	Brain	gene expression	LOC134483298	0.06	0.04	9.1e-08	0.08	0.07	0.07	0.08	9.7e-08	2.4e-07	3.2e-07	1.4e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	1.5	2.8	3.3	-1.6	-1.5	-1.8	-1.7	1.6	-1.8
Area under the delay curve	0.3	0.5	0.7	0.6	0.7	0.7	0.8	-0.7	0.5
BMI with tail	2.4	8.3	9.6	2.9	2.8	2.7	2.8	-2.8	3.1
BMI without tail	0.1	0.7	1.0	0.8	0.7	0.9	1.0	-0.9	0.6
Body weight	0.4	1.9	3.0	1.1	1.4	1.4	1.3	-1.3	1.7
Weight adjusted by age	1.6	4.8	6.8	2.1	2.3	1.8	2.0	-2.1	2.6
Bone surface	0.6	1.3	2.0	-1.4	-1.1	-1.1	-1.0	1.1	-1.1
Bone volume	1.8	3.6	4.7	-2.2	-1.8	-1.9	-1.9	1.9	-1.7
Breakpoint value in progressive ratio session	0.4	0.7	1.4	-0.8	-0.7	-0.8	-0.6	0.8	-1.2
Number of licking bursts	0.2	0.6	0.7	-0.8	-0.7	-0.8	-0.8	0.8	-0.8
Context. condit. distance diff. score	3.3	4.0	5.0	2.2	2.0	2.2	2.2	-2.0	0.9
Locomotion velocity, session 1	0.6	0.7	1.2	-0.9	-1.1	-0.4	-0.5	0.7	-1.1
Locomotion distance, session 1	0.1	0.1	0.4	0.0	-0.0	-0.1	-0.1	0.2	-0.6
Locomotion velocity, session 2	0.1	0.2	0.7	-0.2	-0.3	0.3	0.1	0.0	-0.9
Locomotion distance, session 2	0.1	0.1	0.3	0.5	0.5	0.4	0.3	-0.3	-0.0
Locomotion velocity, session 3	2.6	3.0	3.6	1.7	1.6	1.7	1.7	-1.7	1.9
Locomotion distance, session 3	0.4	0.4	0.5	0.7	0.7	0.6	0.6	-0.6	0.6
Stereotopy head waving bouts, day 3	0.8	1.0	1.3	1.0	0.8	1.1	1.1	-1.0	0.9
Stereotopy head waving duration, day 3	1.2	1.4	1.8	1.2	1.0	1.4	1.2	-1.2	1.1
Locomotion velocity, session 7	1.0	1.1	1.6	1.1	1.3	1.1	1.1	-1.1	0.5
Locomotion distance, session 7	0.3	0.3	1.3	-0.2	-0.2	-0.5	-0.5	0.4	-1.1
Stereotopy head waving bouts, day 7	1.3	1.5	2.7	1.0	1.0	1.2	1.2	-1.1	1.6
Stereotopy head waving duration, day 7	0.1	0.1	0.5	-0.2	-0.1	0.1	0.1	0.0	0.7
Locomotion velocity, session 8	0.7	0.9	1.2	1.0	0.9	1.1	1.1	-0.9	0.3
Locomotion distance, session 8	1.2	1.7	2.3	1.5	1.4	1.5	1.4	-1.3	0.3
Degree of sensitization distance	0.3	0.3	0.9	-0.3	-0.4	-0.4	-0.5	0.4	-1.0
Degree of sensitization stereotypy	1.1	1.2	2.1	0.8	1.0	1.1	1.1	-1.0	1.4
Conditioned locomotion	0.2	0.2	0.3	-0.3	-0.5	-0.5	-0.4	0.4	-0.5
Cocaine response after cond. corrected	1.0	1.5	2.4	1.5	1.4	1.2	1.3	-1.2	0.7
Cocaine response after cond. not corrected	0.8	1.1	1.6	1.3	1.3	1.0	1.0	-1.0	0.8
Cocaine response before conditioning	1.3	1.6	2.4	-1.6	-1.2	-1.3	-1.4	1.3	-0.6
Saline control response	2.2	3.0	5.6	-1.5	-1.6	-1.6	-1.5	1.7	-2.4
Bone: connectivity density	1.3	2.1	3.0	-1.3	-1.2	-1.5	-1.4	1.4	-1.7
Bone: cortical apparent density	0.1	0.1	0.5	0.7	0.4	0.3	0.3	-0.4	-0.1
Bone: cortical area	0.2	0.3	0.5	-0.7	-0.6	-0.6	-0.5	0.6	-0.5
Bone: cortical porosity	0.2	0.2	0.8	0.2	0.6	-0.0	0.1	-0.1	0.9
Bone: cortical porosity	0.1	0.1	0.3	-0.1	0.3	-0.4	-0.3	0.2	0.5
Bone: cortical thickness	0.1	0.1	0.2	-0.1	-0.3	-0.4	-0.4	0.3	-0.2
Bone: cortical thickness	0.1	0.1	0.3	0.3	0.5	0.3	0.3	-0.3	0.0
Bone: cortical tissue density	0.1	0.2	0.6	0.8	0.5	0.4	0.4	-0.5	0.0
Condit. Reinf. active minus inactive responses	0.6	0.7	1.1	1.0	1.0	0.8	0.8	-0.8	0.5
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.5	1.1	1.2	1.2	1.1	-1.0	0.5
Condit. Reinf. active responses	0.0	0.0	0.0	-0.1	-0.0	-0.2	-0.2	0.2	0.0
Condit. Reinf. inactive responses	2.8	3.7	4.3	-2.1	-2.0	-2.1	-2.0	2.0	-1.2
Incentive salience index mean	0.2	0.3	0.4	-0.5	-0.4	-0.5	-0.6	0.6	-0.6
Condit. Reinf. lever presses	1.5	2.3	3.2	-1.8	-1.5	-1.4	-1.5	1.6	-1.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.5	0.4	0.3	0.3	-0.3	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.5	0.4	0.3	0.2	0.2	-0.4	0.7
Condit. Reinf. active responses	0.1	0.1	0.1	0.3	0.1	0.3	0.3	-0.3	0.1
Condit. Reinf. inactive responses	0.2	0.4	0.7	0.6	0.5	0.8	0.8	-0.6	0.2
Condit. Reinf. lever presses	0.6	0.9	1.0	0.9	0.9	1.0	1.0	-0.9	0.8
Condit. Reinf. lever reinforcers received	0.3	0.4	0.5	0.7	0.5	0.7	0.7	-0.7	0.6
Conditioned reinforcement - actives	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.1	0.3	-0.2
Conditioned reinforcement - inactives	0.1	0.3	0.5	0.4	0.4	0.7	0.6	-0.4	0.5
Conditioned locomotion	0.0	0.1	0.1	-0.3	-0.2	-0.1	-0.1	0.2	-0.3
Patch foraging indifference point 0 sec	0.5	1.4	2.3	1.1	1.2	1.5	1.3	-1.2	0.6
Patch foraging indifference point AUC	0.9	2.0	2.6	-1.2	-1.4	-1.6	-1.4	1.4	-1.5
Delay disc. indifference point, 0s delay	1.2	1.4	1.8	-1.1	-1.3	-1.2	-1.1	1.3	-1.0
Delay disc. indifference point, 16s delay	0.9	1.2	1.5	0.9	1.1	1.1	1.1	-1.1	1.2
Delay disc. indifference point, 2s delay	0.7	0.8	1.2	0.8	0.7	0.8	0.9	-0.9	1.1
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	-0.0	0.0	0.1	0.1	-0.1	0.0
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	0.3	0.2	0.3	0.3	-0.2	-0.2
Delay disc. indifference point, 8s delay	0.7	1.1	1.4	1.0	1.1	1.2	1.2	-1.1	0.7
Indifference point function ln k	0.7	2.3	2.7	1.5	1.6	1.7	1.6	-1.6	1.1
Indifference point function log k	0.7	2.3	2.7	1.5	1.6	1.7	1.6	-1.6	1.1
Patch foraging total patch changes 0 sec	0.6	1.9	3.0	1.3	1.4	1.7	1.5	-1.4	0.8
Patch foraging total patch changes 12 sec	1.0	1.3	3.6	-0.7	-1.1	-0.9	-0.9	1.0	-1.9
Patch foraging total patch changes 18 sec	1.1	2.6	4.3	-1.4	-1.6	-1.5	-1.5	1.5	-2.1
Patch foraging total patch changes 24 sec	0.2	0.8	2.0	-0.8	-0.9	-0.6	-0.6	0.8	-1.4
Patch foraging total patch changes 6 sec	0.1	0.2	0.6	-0.3	-0.2	-0.1	-0.3	0.3	-0.8
Patch foraging time to switch 0 sec	0.0	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.2
Patch foraging water rate 0 sec	0.0	0.1	0.2	-0.2	-0.5	-0.3	-0.3	0.3	-0.4
Patch foraging water rate 12 sec	0.1	0.6	1.0	-0.9	-1.0	-0.6	-0.7	0.7	-0.6
Patch foraging water rate 18 sec	1.3	2.9	4.6	-2.0	-2.1	-1.6	-1.6	1.7	-0.9
Patch foraging water rate 24 sec	0.0	0.0	0.1	-0.2	-0.3	-0.2	-0.2	0.2	-0.1
Patch foraging water rate 6 sec	3.3	4.8	6.2	-2.3	-2.5	-1.9	-2.0	2.1	-2.2
Seeking ratio, delayed vs. immediate footshock	4.3	6.2	7.2	2.7	2.5	2.7	2.5	-2.5	2.1
Distance traveled before self-admin	1.5	3.2	3.7	1.7	1.8	1.9	1.8	-1.8	1.7
Distance traveled after self-admin	0.1	0.2	0.7	0.2	0.2	0.2	0.2	-0.3	0.9
Extensor digitorum longus weight	0.1	0.3	0.5	-0.3	-0.6	-0.7	-0.7	0.4	0.0
Bone: elastic displacement	0.0	0.0	0.1	0.2	0.0	-0.3	-0.3	0.1	-0.1
Bone: elastic work	0.0	0.0	0.1	-0.0	-0.0	-0.2	-0.3	0.1	0.1
Bone: endosteal estimation	0.0	0.1	0.1	-0.0	0.2	0.4	0.3	-0.2	0.0
Bone: endosteal perimeter	0.1	0.4	0.8	0.2	0.6	0.9	0.8	-0.6	0.1
Epididymis fat weight	0.1	0.8	0.9	0.9	0.9	0.9	0.9	-0.8	0.8
Delta time in closed arm before/after self-admin	0.5	0.4	0.5	0.7	0.6	0.7	0.6	-0.7	0.6
Delta time in open arm before/after self-admin	0.7	0.9	1.0	-1.0	-0.9	-0.9	-0.9	0.9	-1.0
Diff in mean of infusions in LGA sessions	0.0	0.1	0.2	0.1	0.2	0.1	0.1	-0.0	-0.5
Delay discount exponential model param	0.3	0.4	0.6	-0.6	-0.7	-0.7	-0.8	0.7	-0.5
Extinction: sum of active levers before priming	3.2	4.9	5.4	2.2	2.2	2.0	2.3	-2.2	2.3
Active lever presses in extinction session 6	0.0	0.0	0.2	0.1	0.1	0.1	-0.0	-0.2	0.4
Bone: final force	1.3	2.1	2.8	-1.7	-1.4	-1.6	-1.5	1.5	-0.8
Bone: final moment	0.8	1.3	1.8	-1.3	-1.1	-1.3	-1.2	1.2	-0.5
Food consumed during 24 hour testing period	4.4	8.7	9.2	-3.0	-3.0	-2.9	-2.9	3.0	-2.9
Glucose	0.2	0.3	1.0	-1.0	-0.5	-0.5	-0.4	0.6	0.0
Heart weight	1.3	2.1	3.0	1.2	1.5	1.7	1.7	-1.5	0.9
Delay discount hyperbolic model param	0.3	0.4	0.6	-0.6	-0.6	-0.7	-0.8	0.6	-0.4
Intermittent access intake day 1-15 change	1.3	7.0	7.4	-2.7	-2.7	-2.5	-2.7	2.7	-2.6
Intermittent access intake escalation	1.0	5.3	5.7	-2.4	-2.4	-2.1	-2.3	2.3	-2.3
Intermittent access intake escalation 2	2.3	3.9	5.2	-2.0	-2.0	-1.6	-1.9	2.0	-2.3
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.2	0.2	0.2	0.2	-0.1	0.3
Intermitt. access day 15 inactive lever presses	0.2	1.0	1.4	1.0	1.0	1.2	1.0	-1.0	0.6
Intermitt. access escalation Index	0.1	0.3	0.6	0.5	0.5	0.7	0.5	-0.6	0.3
Intermittent access day 1 total infusions	0.8	2.4	2.7	1.6	1.6	1.3	1.6	-1.5	1.7
Intermittent access day 15 total infusions	0.0	0.0	0.0	-0.0	0.0	-0.0	0.0	-0.0	0.1
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.1	0.3	0.3	0.3	0.3	-0.3	0.1
Intermittent access total infusions	0.0	0.0	0.0	0.1	0.1	-0.0	0.1	-0.1	0.1
Intermittent access day 1 locomotion	0.1	0.2	0.7	0.3	0.3	0.1	0.3	-0.3	0.8
Intermittent access day 15 total locomotion	0.0	0.1	0.6	0.2	0.2	0.2	0.2	-0.3	0.8
Intermittent access total locomotion	0.0	0.1	0.3	0.1	0.1	0.0	0.2	-0.1	0.5
Intermittent access standard deviation	0.3	1.8	1.9	-1.4	-1.3	-1.2	-1.3	1.4	-1.4
Left kidney weight	0.6	4.6	5.9	-2.0	-2.2	-2.4	-2.3	2.2	-1.7
Right kidney weight	0.1	0.9	1.2	-0.9	-0.9	-1.1	-1.1	1.1	-0.7
Cocaine induced anxiety	0.3	0.8	1.2	0.9	1.0	1.1	1.0	-0.9	0.2
Post-drug Anxiety	0.4	0.5	0.7	0.7	0.8	0.8	0.8	-0.7	0.2
Baseline Anxiety	0.2	0.3	0.6	-0.6	-0.6	-0.8	-0.6	0.5	-0.3
Tail length	0.8	4.2	5.2	-2.3	-2.1	-1.9	-2.0	2.0	-1.9
Length with tail	0.2	0.8	1.4	-1.2	-0.8	-0.9	-1.0	1.0	-0.3
Length without tail	0.1	0.5	1.7	0.5	0.7	0.6	0.4	-0.5	1.3
Times rat made contact with spout	0.1	0.1	0.2	-0.4	-0.5	-0.3	-0.3	0.3	-0.1
Lifetime Intake	0.0	0.0	0.0	-0.0	-0.0	-0.2	0.0	0.1	-0.2
Liver weight, left	0.1	0.1	0.2	-0.5	-0.2	-0.3	-0.3	0.4	-0.3
Liver weight, right	0.0	0.1	0.1	-0.1	-0.2	-0.3	-0.4	0.3	0.3
Locomotor activity	0.3	0.5	1.2	0.4	0.7	0.7	0.6	-0.7	1.1
Locomotor testing distance	0.2	0.5	0.7	0.5	0.8	0.9	0.6	-0.7	0.8
Locomotor testing rearing	0.2	0.7	1.3	-0.9	-0.7	-0.5	-0.7	0.8	-1.2
Locomotion in novel chamber	0.3	0.4	0.6	0.6	0.6	0.6	0.5	-0.6	0.8
Locomotion in novel chamber post-restriction	0.3	0.8	1.4	-1.2	-0.9	-1.1	-0.8	0.9	-0.2
Fecal boli incidents, locomotor time 1	0.5	1.3	2.6	-1.0	-0.9	-1.0	-1.0	1.1	-1.6
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.2	0.0	0.1	0.1	-0.1	0.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.5	-0.3	-0.4	-0.3	0.4	0.2
Bouts of movement, locomotor time 1	0.7	0.9	1.2	-0.9	-1.0	-1.0	-0.9	0.9	-1.1
Total resting periods, locomotor time 1	0.3	0.4	0.7	-0.6	-0.6	-0.6	-0.5	0.5	-0.8
Rest time, locomotor task time 1	0.4	0.6	0.8	-0.6	-0.9	-0.8	-0.7	0.7	-0.9
Distance moved, locomotor task time 1	0.3	0.8	1.0	0.9	1.0	0.8	0.8	-0.8	1.0
Vertical activity count, locomotor time 1	0.1	0.5	0.7	-0.7	-0.6	-0.7	-0.8	0.8	-0.4
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.6	0.6	0.3	0.4	0.4	-0.5	0.8
Bouts of movement, locomotor time 2	0.0	0.1	0.2	0.3	0.2	0.3	0.2	-0.3	0.5
Total resting periods, locomotor time 2	0.0	0.0	0.0	0.0	-0.0	0.1	0.1	-0.1	0.1
Rest time, locomotor task time 2	0.2	0.3	1.2	-0.2	-0.3	-0.4	-0.3	0.3	-1.1
Distance moved, locomotor task time 2	1.5	2.0	3.9	1.3	1.3	1.2	1.2	-1.3	2.0
Vertical activity count, locomotor time 2	0.1	0.3	0.4	-0.4	-0.5	-0.5	-0.7	0.6	-0.2
Light reinforcement 1	6.2	28.3	29.0	-5.3	-5.4	-5.3	-5.3	5.4	-5.2
Light reinforcement 2	6.7	15.0	16.8	-4.1	-4.0	-3.7	-3.7	3.8	-3.9
Bone: marrow area	0.0	0.1	0.2	0.0	0.2	0.5	0.4	-0.3	0.1
Bone: maximum diameter	0.2	0.5	0.8	0.4	0.7	0.9	0.9	-0.7	0.6
Bone: maximum force	0.2	0.4	0.7	-0.8	-0.4	-0.7	-0.6	0.7	-0.2
Bone: maximum moment	0.1	0.1	0.3	-0.5	-0.2	-0.4	-0.3	0.4	0.0
Mean time between licks in bursts	0.1	0.3	0.4	0.5	0.7	0.6	0.6	-0.5	0.5
Mean num. licks in bursts	0.1	0.2	0.4	0.5	0.3	0.5	0.5	-0.6	0.6
Cd content in liver	1.2	1.4	2.4	1.6	1.2	1.2	1.2	-1.2	0.3
Co content in liver	1.3	1.6	2.1	1.4	1.4	1.3	1.3	-1.3	0.7
Cu content in liver	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.2	0.1	0.1
Fe content in liver	2.0	2.5	3.2	-1.7	-1.7	-1.8	-1.8	1.5	-0.6
K content in liver	0.8	0.8	1.9	0.9	0.9	0.5	0.5	-0.7	1.4
Mg content in liver	0.6	0.7	1.0	1.0	0.9	0.6	0.6	-0.8	1.0
Mn content in liver	0.8	0.9	2.0	1.4	1.1	0.8	0.8	-0.9	0.3
Na content in liver	0.1	0.1	0.3	-0.4	-0.2	-0.3	-0.2	0.2	0.5
Rb content in liver	0.8	0.9	1.3	-0.8	-0.8	-1.1	-1.2	1.0	-0.8
Se content in liver	2.0	2.4	3.2	-1.6	-1.6	-1.7	-1.8	1.5	-0.7
Sr content in liver	0.4	0.3	0.4	0.5	0.5	0.5	0.6	-0.5	0.7
Zn content in liver	2.0	2.4	3.0	1.7	1.4	1.6	1.7	-1.6	1.2
Bone: minimum diameter	1.1	2.0	2.3	-1.5	-1.5	-1.4	-1.4	1.4	-1.4
Time in familiar zone, hab. session 1	0.8	0.9	1.4	-0.9	-1.2	-0.8	-0.9	1.0	-0.9
Time in novel zone, hab. session 1	0.7	0.8	1.1	0.9	1.0	0.7	0.7	-0.9	1.1
Total zone transitions, hab. session 1	0.2	0.3	0.4	0.4	0.6	0.6	0.6	-0.5	0.1
Total locomotion distance, hab. session 1	0.4	0.6	0.8	0.9	0.9	0.8	0.8	-0.8	0.4
Locomotion velocity, hab. session 1	0.4	0.5	0.7	0.8	0.8	0.8	0.8	-0.8	0.2
Time in familiar zone, hab. session 2	1.6	1.8	3.3	-1.2	-1.4	-1.0	-1.1	1.2	-1.8
Time in novel zone, hab. session 2	3.1	3.4	4.1	2.0	2.0	1.6	1.7	-1.9	1.9
Total zone transitions, hab. session 2	0.0	0.0	0.1	-0.2	0.1	0.0	-0.0	0.1	-0.3
Total locomotion distance, hab. session 2	0.0	0.1	0.1	0.3	0.2	0.2	0.2	-0.2	-0.4
Locomotion velocity, hab. session 2	0.0	0.0	0.3	-0.0	-0.1	-0.1	-0.1	0.1	-0.5
Novel to familiar place preference ratio	1.2	1.6	2.2	1.2	1.5	1.0	1.2	-1.2	1.4
Novelty place preference	0.9	1.2	1.7	1.0	1.3	0.9	1.0	-1.0	1.3
Time in novel zone, NPP test	1.0	1.2	2.0	0.9	1.3	0.9	1.0	-1.1	1.4
Total zone transitions, NPP test	0.0	0.0	0.2	0.2	0.0	-0.0	0.0	0.0	-0.4
Total locomotion distance, NPP test	0.1	0.1	0.3	0.5	0.2	0.3	0.3	-0.4	0.1
Locomotion velocity, NPP test	0.0	0.0	0.1	0.3	-0.1	-0.0	-0.0	-0.0	-0.3
Intraocular pressure	4.0	6.5	7.6	2.7	2.4	2.8	2.7	-2.7	1.9
Delta distance traveled before/after self-admin	2.4	2.7	3.5	-1.6	-1.7	-1.9	-1.7	1.7	-1.1
Delta ambulatory time before/after self-admin	2.8	4.8	5.6	-2.1	-2.1	-2.4	-2.3	2.3	-1.9
Parametrial fat weight	0.0	0.1	0.3	-0.2	0.0	-0.2	-0.0	0.2	-0.6
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.1	0.0	0.0	0.2	-0.1	-0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.2	0.2	0.1	-0.0	-0.1	0.0
Pavlov. Cond. change in total contacts	0.9	0.9	1.3	-1.2	-1.0	-0.8	-1.0	0.9	-0.8
Pavlov. Cond. index score	0.1	0.1	0.2	0.3	0.5	0.3	0.1	-0.3	0.4
Pavlov. Cond. latency score	0.1	0.1	0.2	0.3	0.4	0.3	0.1	-0.2	0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.0	0.2	0.2	-0.0	-0.1	0.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.2	-0.3	-0.3	-0.1	0.3	-0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.5	0.2	0.2	0.3	-0.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	0.5	0.6	0.5	0.3	-0.4	0.5
Pavlov. Cond. response bias	0.0	0.1	0.3	0.1	0.1	0.2	-0.0	-0.1	0.5
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.7	0.7	0.4	0.4	-0.6	0.4
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.3	-0.3	-0.0	-0.1	0.2	-0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.2	-0.3	-0.0	-0.0	0.1	0.1
Pavlov. Cond. index score	0.0	0.0	0.1	-0.3	-0.3	-0.0	-0.1	0.2	0.0
Pavlov. Cond. latency score	0.0	0.1	0.2	-0.3	-0.4	-0.1	-0.2	0.3	-0.1
Pavlov. Cond. lever contacts	0.5	0.7	1.0	-1.0	-1.0	-0.7	-0.7	0.9	-0.7
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	0.0	-0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.9	1.1	-0.8	-0.9	-1.0	-1.1	1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.3	-0.3	-0.0	-0.0	0.2	0.1
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.6	-0.5	-0.2	-0.2	0.4	-0.1
Time in closed arm before self-admin	2.3	4.1	4.9	-2.2	-2.0	-2.1	-2.0	2.0	-1.8
Time in closed arm after self-admin	1.3	1.4	1.5	-1.2	-1.2	-1.1	-1.2	1.1	-1.2
Time in open arm before self-admin	1.6	1.9	2.3	1.5	1.4	1.4	1.4	-1.3	1.3
Time in open arm after self-admin	1.1	1.2	1.6	1.1	1.0	1.1	1.1	-1.0	1.3
Bone: periosteal estimation	0.1	0.1	0.3	-0.5	-0.3	-0.2	-0.2	0.3	-0.4
Bone: periosteal perimeter	0.1	0.2	0.5	0.2	0.5	0.7	0.7	-0.5	0.1
Bone: post-yield work	0.2	0.3	0.7	-0.2	0.5	0.7	0.8	-0.5	0.2
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.0	0.0	-0.2	0.1	0.0	0.4
Progressive ratio test 1 breakpoint	0.0	0.0	0.2	0.0	0.0	-0.1	0.1	0.0	0.4
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.3	0.2	0.3	0.2	0.3	-0.2	0.6
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.2	0.2	-0.1	0.2	-0.1	0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.3	0.3	0.0	0.3	-0.2	0.4
Progressive ratio test 2 inactive lever presses	0.5	1.5	1.7	1.2	1.2	1.3	1.3	-1.2	1.0
Incentive Sensitization - Responses	0.0	0.0	0.0	0.2	0.1	-0.1	0.0	-0.0	-0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0	0.1	-0.1
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.2	0.4	0.4	0.4	0.4	-0.4	0.4
Progressive ratio	0.1	0.4	0.9	-0.5	-0.7	-0.4	-0.4	0.4	-1.0
Food seeking constrained by brief footshock	2.3	2.9	3.5	-1.9	-1.8	-1.6	-1.6	1.7	-1.7
Seeking ratio, punishment vs. effort	0.5	1.1	1.5	-1.2	-1.0	-1.2	-1.2	1.2	-0.5
Retroperitoneal fat weight	0.2	0.8	1.3	1.1	1.1	0.8	0.9	-0.8	0.0
Reaction time number correct	0.3	1.1	1.5	1.2	1.0	1.0	0.9	-1.1	0.9
Reaction time mean minus median	0.3	2.0	5.2	1.2	1.1	1.2	1.2	-1.2	2.3
Reaction time mean minus median AUC	0.3	1.7	3.2	1.3	1.1	1.2	1.2	-1.2	1.8
Reaction time num false alarms	3.6	6.2	7.8	2.6	2.6	2.8	2.7	-2.5	1.6
Reaction time num false alarms AUC	2.4	5.5	6.7	2.4	2.4	2.6	2.5	-2.4	1.6
Reaction time trials correct on left	0.3	1.1	1.5	1.2	1.0	1.0	0.9	-1.1	0.9
Reaction time trials on left	0.4	1.3	1.7	1.3	1.1	1.1	1.0	-1.2	1.0
Reaction time mean	1.7	3.8	5.9	2.1	1.7	1.7	1.8	-1.9	2.4
Reaction time mean AUC	1.6	3.8	5.9	2.0	1.7	1.7	1.8	-1.9	2.4
Median of all reaction times	2.0	3.1	4.2	2.0	1.6	1.5	1.7	-1.7	2.0
Reaction time omissions	2.3	3.7	5.1	1.9	1.9	1.7	1.8	-1.8	2.3
Reaction time false alarm rate	1.5	2.1	2.9	1.4	1.5	1.7	1.6	-1.4	0.8
Reaction time premature initiation rate	3.9	6.0	8.6	-2.3	-2.3	-2.4	-2.2	2.4	-2.9
Reaction time premature initiations	0.8	2.5	4.2	-1.4	-1.4	-1.5	-1.4	1.6	-2.0
Std. dev. reaction times	0.6	2.1	4.0	1.3	1.2	1.3	1.3	-1.4	2.0
Reaction time trials completed	0.4	1.3	1.7	1.3	1.1	1.1	1.0	-1.2	1.0
Reaction time trials AUC	0.4	1.4	1.9	1.4	1.1	1.2	1.1	-1.2	1.0
Run reversals in cocaine runway, females	0.4	0.4	0.7	0.6	0.6	0.6	0.6	-0.6	0.8
Run reversals in cocaine runway, males	0.2	0.2	0.5	0.4	0.6	0.2	0.2	-0.4	0.7
Latency to leave start box in cocaine runway	0.2	0.3	0.7	0.5	0.5	0.8	0.6	-0.6	0.4
Latency to leave start box in cocaine runway, F	0.8	1.0	1.4	0.9	0.9	1.0	0.9	-1.1	1.2
Latency to leave start box in cocaine runway, M	0.5	0.5	1.5	-0.6	-0.6	-0.2	-0.4	0.6	-1.2
Std. dev. time between licks in bursts	0.2	0.3	0.4	-0.3	-0.4	-0.7	-0.7	0.6	-0.5
Total sessions with >9 infusions	0.0	0.0	0.1	0.1	0.1	-0.2	0.1	-0.0	0.4
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.1	-0.2	-0.4	-0.2	0.3	0.0
Short access day 10 total inactive lever presses	0.1	0.4	0.5	-0.6	-0.6	-0.6	-0.6	0.7	-0.5
Short access day 1 total infusions	0.4	0.8	0.9	1.0	0.9	0.8	0.9	-0.9	0.9
Short access day 10 total infusions	0.0	0.0	0.1	0.0	-0.0	-0.3	-0.1	0.1	0.0
Short access total infusions	0.0	0.0	0.1	0.2	0.2	0.0	0.3	-0.1	0.1
Short access day 1 locomotion	1.6	2.6	2.8	1.7	1.6	1.5	1.6	-1.6	1.7
Short access day 10 total locomotion	0.0	0.1	0.2	0.4	0.3	0.2	0.4	-0.3	0.4
Short access total locomotion	0.4	0.6	0.7	0.8	0.7	0.6	0.8	-0.8	0.8
One hour access (0.3 mA shock)	0.2	0.3	0.4	0.5	0.5	0.6	0.6	-0.5	-0.0
Compulsive drug intake	0.0	0.1	0.1	0.1	0.1	0.4	0.2	-0.3	-0.3
One hour access (shock baseline)	0.1	0.2	0.2	0.4	0.4	0.4	0.5	-0.4	0.2
Social response proportion	0.0	0.0	0.1	0.3	0.1	-0.2	-0.3	0.1	0.2
Social responses	0.1	0.1	0.2	0.3	0.4	0.3	0.2	-0.2	-0.2
Social time	0.9	1.4	2.0	-1.0	-1.1	-1.4	-1.4	1.2	-0.9
Soleus weight	0.0	0.1	0.3	0.1	0.6	0.4	0.5	-0.3	-0.1
Bone: stiffness	0.1	0.1	0.4	-0.6	-0.1	-0.2	-0.1	0.3	0.1
Tibialis anterior weight	0.4	1.5	1.7	1.3	1.1	1.1	1.2	-1.2	1.3
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.2	0.1	0.1	0.2	-0.2	-0.2
Time to tail flick, vehicle, after self-admin	0.3	0.6	1.5	-0.6	-0.7	-0.6	-0.6	0.7	-1.2
Time to tail flick, test, before self-admin	1.0	1.2	1.6	1.2	1.0	1.2	1.3	-1.2	0.4
Time to tail flick, test, after self-admin	0.7	0.7	1.0	-1.0	-1.0	-0.9	-0.8	0.8	-0.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.4	0.7	-0.5	-0.6	-0.5	-0.5	0.6	-0.8
Delta time to tail flick, test, before/after SA	1.0	1.2	1.6	-1.3	-1.2	-1.3	-1.2	1.1	0.3
Tibia length	0.3	0.8	3.6	-0.1	0.4	0.6	0.6	-0.5	1.9
Ambulatory time before self-admin	1.3	3.9	4.4	1.9	2.0	2.1	2.0	-2.1	1.9
Ambulatory time after self-admin	0.1	0.2	0.4	-0.5	-0.4	-0.5	-0.6	0.5	-0.1
Bone: tissue strength	0.1	0.1	0.2	0.0	-0.0	-0.5	-0.4	0.3	0.1
Total heroin consumption	0.2	0.2	0.3	0.5	0.4	0.5	0.5	-0.4	0.0
Bone: trabecular number	1.3	2.4	3.0	-1.5	-1.3	-1.7	-1.7	1.5	-1.6
Bone: trabecular spacing	0.8	1.1	2.0	1.4	1.0	1.0	0.9	-1.0	1.0
Bone: trabecular thickness	2.7	3.7	4.4	-2.0	-1.9	-2.1	-2.0	1.9	-1.6
Bone: trabecular tissue density	0.4	0.6	0.8	0.9	0.6	0.8	0.9	-0.8	0.8
Water consumed over 24 hours	1.8	3.4	3.9	-2.0	-1.9	-1.8	-1.8	1.9	-1.6
Number of responses in last shaping day	1.5	1.9	2.2	1.4	1.4	1.5	1.5	-1.4	1.1