LOC134483093

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression LOC134483093 0.05 0.04 1.1e-05 0.06 0.05 0.05 0.05 2.0e-05 5.6e-05 3.8e-05 4.8e-05
2 IC gene expression LOC134483093 0.74 0.11 1.9e-03 -0.01 0 0.03 0 8.7e-01 2.3e-01 2.8e-02 3.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.40.70.8-0.80.9
Area under the delay curve1.11.21.9-0.71.4
BMI with tail0.72.65.00.52.2
BMI without tail1.13.35.6-1.02.4
Body weight1.87.714.5-3.81.0
Weight adjusted by age0.10.20.30.20.6
Bone surface1.12.02.4-1.51.3
Bone volume1.01.82.1-1.51.2
Breakpoint value in progressive ratio session1.41.73.1-1.80.5
Number of licking bursts2.33.85.92.41.3
Context. condit. distance diff. score0.40.51.00.11.0
Locomotion velocity, session 10.60.70.90.7-0.9
Locomotion distance, session 10.40.50.6-0.80.7
Locomotion velocity, session 20.50.60.80.7-0.9
Locomotion distance, session 20.91.21.71.30.9
Locomotion velocity, session 30.20.30.50.70.1
Locomotion distance, session 33.64.04.4-1.92.1
Stereotopy head waving bouts, day 32.42.95.30.7-2.3
Stereotopy head waving duration, day 32.63.14.81.2-2.2
Locomotion velocity, session 70.40.50.5-0.70.7
Locomotion distance, session 70.10.10.2-0.4-0.1
Stereotopy head waving bouts, day 71.01.22.21.50.4
Stereotopy head waving duration, day 71.11.42.71.6-0.2
Locomotion velocity, session 82.12.55.02.20.3
Locomotion distance, session 81.11.61.91.11.4
Degree of sensitization distance1.31.42.10.8-1.4
Degree of sensitization stereotypy1.11.21.71.30.9
Conditioned locomotion0.10.10.20.50.1
Cocaine response after cond. corrected1.11.32.50.2-1.6
Cocaine response after cond. not corrected1.51.73.50.1-1.9
Cocaine response before conditioning0.70.91.4-1.20.6
Saline control response0.20.30.60.2-0.8
Bone: connectivity density0.20.30.3-0.60.6
Bone: cortical apparent density1.01.42.31.50.7
Bone: cortical area0.71.12.1-1.4-0.5
Bone: cortical porosity0.70.81.01.00.8
Bone: cortical porosity1.01.11.61.30.8
Bone: cortical thickness0.30.50.6-0.8-0.6
Bone: cortical thickness0.50.60.70.9-0.7
Bone: cortical tissue density1.21.72.61.60.9
Condit. Reinf. active minus inactive responses0.30.40.60.40.8
Condit. Reinf. active-inactive response ratio0.10.10.10.4-0.3
Condit. Reinf. active responses1.01.22.11.40.6
Condit. Reinf. inactive responses0.91.12.01.40.4
Incentive salience index mean0.50.71.20.41.1
Condit. Reinf. lever presses0.50.71.4-0.11.2
Condit. Reinf. active minus inactive responses1.11.42.6-1.6-0.5
Condit. Reinf. active-inactive response ratio0.30.40.70.2-0.8
Condit. Reinf. active responses2.23.16.1-2.50.4
Condit. Reinf. inactive responses3.14.06.7-2.61.2
Condit. Reinf. lever presses4.56.212.4-3.50.1
Condit. Reinf. lever reinforcers received2.43.46.4-2.50.6
Conditioned reinforcement - actives0.40.61.11.1-0.3
Conditioned reinforcement - inactives0.40.71.0-0.61.0
Conditioned locomotion1.11.52.91.70.1
Patch foraging indifference point 0 sec0.10.10.2-0.50.2
Patch foraging indifference point AUC0.50.71.31.1-0.4
Delay disc. indifference point, 0s delay4.54.99.6-0.53.1
Delay disc. indifference point, 16s delay1.82.03.1-1.01.8
Delay disc. indifference point, 2s delay0.80.91.4-1.20.6
Delay disc. indifference point, 24s delay1.51.73.3-1.80.4
Delay disc. indifference point, 4s delay0.70.71.40.21.2
Delay disc. indifference point, 8s delay0.30.40.7-0.30.9
Indifference point function ln k0.30.50.9-0.9-0.0
Indifference point function log k0.30.50.9-0.9-0.0
Patch foraging total patch changes 0 sec0.10.20.3-0.50.3
Patch foraging total patch changes 12 sec0.00.00.00.0-0.1
Patch foraging total patch changes 18 sec0.40.60.90.61.0
Patch foraging total patch changes 24 sec0.61.01.8-0.51.3
Patch foraging total patch changes 6 sec0.40.61.2-0.1-1.1
Patch foraging time to switch 0 sec0.20.50.90.90.3
Patch foraging water rate 0 sec0.51.01.60.6-1.3
Patch foraging water rate 12 sec0.10.30.6-0.8-0.1
Patch foraging water rate 18 sec1.52.34.60.1-2.1
Patch foraging water rate 24 sec0.10.10.20.10.4
Patch foraging water rate 6 sec0.60.81.5-1.20.3
Seeking ratio, delayed vs. immediate footshock3.84.68.7-0.73.0
Distance traveled before self-admin0.81.11.8-0.7-1.3
Distance traveled after self-admin3.13.83.8-1.9-1.9
Extensor digitorum longus weight0.20.70.91.0-0.6
Bone: elastic displacement0.50.61.10.0-1.1
Bone: elastic work0.91.22.1-1.50.5
Bone: endosteal estimation0.92.04.0-2.0-0.3
Bone: endosteal perimeter0.81.83.5-1.90.2
Epididymis fat weight0.10.30.60.20.8
Delta time in closed arm before/after self-admin0.80.81.2-1.1-0.6
Delta time in open arm before/after self-admin0.90.91.40.7-1.2
Diff in mean of infusions in LGA sessions0.10.10.10.20.3
Delay discount exponential model param0.70.81.00.8-1.0
Extinction: sum of active levers before priming2.83.14.5-2.11.3
Active lever presses in extinction session 64.64.66.1-1.8-2.5
Bone: final force0.91.52.5-1.60.7
Bone: final moment1.21.93.4-1.80.6
Food consumed during 24 hour testing period0.81.11.2-1.01.1
Glucose0.91.52.60.6-1.6
Heart weight0.30.50.5-0.6-0.7
Delay discount hyperbolic model param0.60.70.90.7-1.0
Intermittent access intake day 1-15 change0.71.42.8-1.70.0
Intermittent access intake escalation0.40.91.8-1.3-0.1
Intermittent access intake escalation 20.80.91.6-1.3-0.5
Intermitt. access day 1 inactive lever presses1.55.76.9-2.62.1
Intermitt. access day 15 inactive lever presses1.22.53.1-1.41.8
Intermitt. access escalation Index0.10.10.20.50.2
Intermittent access day 1 total infusions2.64.14.81.92.2
Intermittent access day 15 total infusions1.21.83.40.41.9
Intermittent access terminal intake (last 3 days)0.81.11.80.61.3
Intermittent access total infusions1.72.03.00.91.7
Intermittent access day 1 locomotion3.34.27.41.02.7
Intermittent access day 15 total locomotion1.01.93.7-0.21.9
Intermittent access total locomotion2.02.43.71.11.9
Intermittent access standard deviation1.94.05.0-2.21.8
Left kidney weight0.94.37.3-2.71.1
Right kidney weight1.25.49.7-3.11.0
Cocaine induced anxiety0.00.00.0-0.00.0
Post-drug Anxiety0.00.00.10.1-0.2
Baseline Anxiety0.00.00.1-0.00.2
Tail length2.610.320.5-4.50.3
Length with tail3.917.133.7-5.8-0.8
Length without tail2.16.911.6-3.4-1.5
Times rat made contact with spout0.70.81.51.2-0.3
Lifetime Intake1.61.92.41.21.6
Liver weight, left0.50.81.11.1-0.7
Liver weight, right1.01.73.20.5-1.8
Locomotor activity0.81.32.30.5-1.5
Locomotor testing distance0.30.61.01.0-0.4
Locomotor testing rearing1.22.34.32.1-0.6
Locomotion in novel chamber0.30.40.7-0.3-0.8
Locomotion in novel chamber post-restriction0.00.10.1-0.2-0.3
Fecal boli incidents, locomotor time 11.52.23.31.1-1.8
Change in fecal boli incidents, locomotor task0.80.81.70.0-1.3
Time >=10cm from walls, locomotor time 10.20.20.40.30.6
Bouts of movement, locomotor time 10.50.61.1-1.00.3
Total resting periods, locomotor time 10.50.61.0-1.00.4
Rest time, locomotor task time 10.70.91.40.6-1.2
Distance moved, locomotor task time 10.50.71.20.41.1
Vertical activity count, locomotor time 10.41.01.7-1.30.6
Time >=10cm from walls, locomotor time 20.50.71.31.1-0.5
Bouts of movement, locomotor time 20.20.20.50.0-0.7
Total resting periods, locomotor time 20.40.81.50.0-1.2
Rest time, locomotor task time 22.02.55.0-0.1-2.2
Distance moved, locomotor task time 22.12.53.71.11.9
Vertical activity count, locomotor time 20.81.12.0-0.51.4
Light reinforcement 10.10.10.20.50.2
Light reinforcement 21.21.82.51.6-1.0
Bone: marrow area1.02.14.1-2.0-0.4
Bone: maximum diameter0.71.32.5-1.60.1
Bone: maximum force1.52.74.6-2.10.9
Bone: maximum moment1.83.15.5-2.40.8
Mean time between licks in bursts0.00.00.0-0.10.2
Mean num. licks in bursts0.91.51.8-1.4-1.1
Cd content in liver0.10.10.20.5-0.2
Co content in liver0.30.40.40.6-0.7
Cu content in liver0.60.71.1-1.0-0.6
Fe content in liver0.10.20.30.50.0
K content in liver0.10.10.1-0.3-0.2
Mg content in liver1.81.93.50.5-1.9
Mn content in liver3.43.77.20.5-2.7
Na content in liver0.40.50.7-0.80.5
Rb content in liver0.40.40.70.30.8
Se content in liver5.05.96.32.5-2.4
Sr content in liver0.80.71.40.2-1.2
Zn content in liver2.12.42.71.6-1.4
Bone: minimum diameter2.13.86.8-2.60.9
Time in familiar zone, hab. session 12.32.34.2-0.5-2.1
Time in novel zone, hab. session 11.41.41.61.11.2
Total zone transitions, hab. session 10.30.40.80.00.9
Total locomotion distance, hab. session 10.91.32.6-1.60.0
Locomotion velocity, hab. session 10.60.91.8-1.3-0.0
Time in familiar zone, hab. session 23.23.33.4-1.8-1.8
Time in novel zone, hab. session 21.41.42.01.40.9
Total zone transitions, hab. session 21.82.34.32.10.5
Total locomotion distance, hab. session 20.10.20.40.10.6
Locomotion velocity, hab. session 20.10.10.20.30.4
Novel to familiar place preference ratio0.00.00.0-0.20.2
Novelty place preference0.00.00.1-0.10.3
Time in novel zone, NPP test0.00.00.10.20.3
Total zone transitions, NPP test0.10.10.20.2-0.4
Total locomotion distance, NPP test1.62.14.0-2.0-0.5
Locomotion velocity, NPP test1.72.44.5-2.1-0.5
Intraocular pressure0.00.00.0-0.00.1
Delta distance traveled before/after self-admin0.91.01.8-1.4-0.4
Delta ambulatory time before/after self-admin1.01.32.3-1.5-0.5
Parametrial fat weight3.07.013.80.4-3.7
Pavlov. Cond. lever latency0.00.00.0-0.20.2
Pavlov. Cond. magazine entry latency0.81.01.11.0-1.1
Pavlov. Cond. change in total contacts0.40.40.50.60.7
Pavlov. Cond. index score0.40.50.60.8-0.6
Pavlov. Cond. latency score0.10.10.30.5-0.2
Pavlov. Cond. lever contacts0.00.00.0-0.2-0.2
Pavlov. Cond. magazine entry number0.40.40.8-0.90.3
Pavlov. Cond. intertrial magazine entries0.20.30.60.80.0
Pavlov. Cond. lever-magazine prob. diff.0.60.81.11.0-0.7
Pavlov. Cond. response bias0.81.01.70.6-1.3
Pavlov. Cond. lever latency3.24.47.42.7-1.2
Pavlov. Cond. magazine entry latency2.53.05.3-2.30.9
Pavlov. Cond. change in total contacts5.18.211.9-3.42.1
Pavlov. Cond. index score3.95.28.5-2.91.4
Pavlov. Cond. latency score3.64.87.6-2.81.4
Pavlov. Cond. lever contacts3.64.97.9-2.81.4
Pavlov. Cond. magazine entry number3.03.65.32.3-1.4
Pavlov. Cond. intertrial magazine entries0.91.32.01.4-0.8
Pavlov. Cond. lever-magazine prob. diff.3.54.67.7-2.81.2
Pavlov. Cond. response bias4.56.19.0-3.01.8
Time in closed arm before self-admin2.63.34.02.01.6
Time in closed arm after self-admin1.41.42.9-0.11.7
Time in open arm before self-admin2.93.25.8-2.4-0.8
Time in open arm after self-admin1.51.62.1-1.1-1.5
Bone: periosteal estimation1.22.64.9-2.2-0.6
Bone: periosteal perimeter1.01.73.0-1.7-0.5
Bone: post-yield work1.92.83.2-1.81.6
Progressive ratio test 1 active lever presses1.31.63.20.11.8
Progressive ratio test 1 breakpoint1.41.83.5-0.01.9
Progressive ratio test 1 inactive lever presses1.82.54.7-0.62.2
Progressive ratio test 2 active lever presses1.82.23.80.72.0
Progressive ratio test 2 breakpoint2.12.44.00.92.0
Progressive ratio test 2 inactive lever presses3.55.810.8-0.83.3
Incentive Sensitization - Responses1.42.03.10.91.8
Incentive Sensitization - Breakpoint1.52.03.10.91.8
Sum of active levers in priming session hrs 5-60.10.00.10.00.3
Progressive ratio0.00.00.1-0.1-0.3
Food seeking constrained by brief footshock2.12.65.0-2.2-0.4
Seeking ratio, punishment vs. effort0.20.30.4-0.70.5
Retroperitoneal fat weight3.012.623.41.4-4.8
Reaction time number correct0.71.42.8-0.2-1.7
Reaction time mean minus median0.10.20.2-0.3-0.5
Reaction time mean minus median AUC0.30.71.0-0.6-1.0
Reaction time num false alarms1.01.41.61.31.1
Reaction time num false alarms AUC0.91.31.81.30.9
Reaction time trials correct on left0.71.42.8-0.2-1.7
Reaction time trials on left0.81.63.1-0.2-1.8
Reaction time mean0.20.40.7-0.00.9
Reaction time mean AUC0.30.40.90.10.9
Median of all reaction times0.50.71.40.21.2
Reaction time omissions0.50.81.50.3-1.2
Reaction time false alarm rate1.82.53.61.21.9
Reaction time premature initiation rate0.20.20.3-0.40.5
Reaction time premature initiations0.20.30.4-0.5-0.6
Std. dev. reaction times0.10.20.3-0.40.6
Reaction time trials completed0.81.63.1-0.2-1.8
Reaction time trials AUC0.91.73.4-0.1-1.8
Run reversals in cocaine runway, females0.40.40.4-0.70.6
Run reversals in cocaine runway, males1.71.73.40.2-1.8
Latency to leave start box in cocaine runway0.20.30.4-0.30.7
Latency to leave start box in cocaine runway, F0.00.00.00.10.2
Latency to leave start box in cocaine runway, M0.50.50.9-0.11.0
Std. dev. time between licks in bursts0.30.40.6-0.80.4
Total sessions with >9 infusions1.11.42.61.60.4
Short access day 1 total inactive lever presses3.74.99.1-0.83.0
Short access day 10 total inactive lever presses2.15.15.6-2.42.1
Short access day 1 total infusions0.20.30.50.40.7
Short access day 10 total infusions1.31.72.21.11.5
Short access total infusions0.91.11.71.30.8
Short access day 1 locomotion1.11.41.71.31.0
Short access day 10 total locomotion3.25.911.3-0.83.4
Short access total locomotion1.92.32.91.31.7
One hour access (0.3 mA shock)1.82.13.7-0.71.9
Compulsive drug intake0.40.50.9-0.3-1.0
One hour access (shock baseline)1.52.24.40.22.1
Social response proportion1.51.73.4-1.8-0.2
Social responses1.82.32.4-1.5-1.6
Social time2.02.74.3-2.11.1
Soleus weight0.20.61.00.3-1.0
Bone: stiffness0.91.52.1-1.50.9
Tibialis anterior weight0.20.81.20.6-1.1
Time to tail flick, vehicle, before self-admin0.40.40.70.80.3
Time to tail flick, vehicle, after self-admin0.30.40.8-0.9-0.2
Time to tail flick, test, before self-admin3.33.56.60.62.6
Time to tail flick, test, after self-admin0.10.10.20.1-0.4
Delta time to tail flick, vehicle, before/after SA0.80.71.5-1.2-0.2
Delta time to tail flick, test, before/after SA6.97.114.1-0.0-3.8
Tibia length1.95.25.8-2.42.2
Ambulatory time before self-admin0.71.01.4-0.8-1.2
Ambulatory time after self-admin4.35.07.2-2.7-1.7
Bone: tissue strength2.52.52.7-1.61.6
Total heroin consumption1.92.23.8-0.82.0
Bone: trabecular number1.42.32.9-1.31.7
Bone: trabecular spacing1.31.72.7-0.8-1.6
Bone: trabecular thickness1.31.62.70.61.6
Bone: trabecular tissue density2.43.64.41.7-2.1
Water consumed over 24 hours0.30.40.4-0.70.5
Number of responses in last shaping day2.02.24.4-0.02.1