LOC134482886

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	LOC134482886	0.38	0.2	2.2e-06	0.24	0.16	0.22	0.21	1.5e-06	9.6e-05	4.4e-06	9.4e-06
2	RMTg	gene expression	LOC134482886	0.18	0.12	1.3e-03	0.07	0.04	0.03	0.04	5.5e-03	4.2e-02	5.5e-02	3.7e-02
3	BLA	gene expression	LOC134482886	0.3	0.15	1.5e-10	0.14	0.16	0.17	0.16	5.1e-08	6.1e-09	3.0e-09	5.5e-09
4	OFC	gene expression	LOC134482886	0.32	0.17	2.5e-05	0.08	0.17	0.16	0.16	6.2e-03	7.2e-05	1.6e-04	1.4e-04
5	pVTA	gene expression	LOC134482886	0.67	0.22	0.0e+00	0.17	0.17	0.18	0.17	1.6e-13	1.0e-13	1.6e-14	1.1e-13
6	NAcc	gene expression	LOC134482886	0.51	0.18	0.0e+00	0.32	0.37	0.38	0.38	1.8e-49	1.1e-59	1.9e-60	8.7e-62
7	Brain	gene expression	LOC134482886	0.26	0.13	0.0e+00	0.15	0.21	0.2	0.22	9.2e-14	6.3e-19	6.9e-19	3.6e-20
8	IC	gene expression	LOC134482886	0.62	0.17	0.0e+00	0.23	0.32	0.32	0.33	3.8e-10	4.6e-14	6.9e-14	1.9e-14
9	PL	gene expression	LOC134482886	0.42	0.17	0.0e+00	0.18	0.29	0.28	0.3	5.4e-19	9.8e-32	3.8e-30	2.9e-33

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.0	0.0	0.1	0.4	0.3	0.3	-0.1	0.1	-0.2	-0.1	-0.1	-0.1
Area under the delay curve	0.1	0.2	0.3	-0.4	-0.6	-0.5	0.5	0.3	0.5	0.3	0.3	0.3
BMI with tail	0.2	0.6	1.8	-1.3	-1.3	-1.1	0.8	-0.1	0.5	-0.2	-0.2	-0.1
BMI without tail	0.1	0.6	1.1	0.4	0.5	0.6	-0.9	0.7	-0.7	-1.0	-1.0	-0.8
Body weight	1.4	6.1	8.4	2.5	2.6	2.7	-2.9	1.8	-2.7	-2.2	-2.2	-2.2
Weight adjusted by age	0.1	0.3	1.1	1.0	0.9	0.6	-0.4	-0.4	-0.1	0.4	0.4	0.4
Bone surface	2.0	3.9	7.2	2.7	2.5	2.5	-2.3	1.2	-2.0	-1.3	-1.3	-1.2
Bone volume	1.6	3.1	5.4	2.3	2.2	2.2	-2.1	1.1	-1.8	-1.2	-1.2	-1.2
Breakpoint value in progressive ratio session	0.2	0.3	0.5	-0.7	-0.7	-0.7	0.6	-0.5	0.5	0.3	0.3	0.3
Number of licking bursts	0.0	0.1	0.2	-0.3	-0.3	-0.4	0.3	-0.5	-0.1	0.2	0.2	-0.0
Context. condit. distance diff. score	0.4	0.5	1.1	-0.4	-0.4	-0.5	0.6	-1.0	0.7	0.7	0.7	0.8
Locomotion velocity, session 1	3.9	4.4	8.5	-0.6	-0.4	-1.3	1.6	-2.9	2.3	2.6	2.6	2.7
Locomotion distance, session 1	1.0	1.3	2.5	1.5	1.4	0.8	-0.4	-1.6	0.3	1.1	1.1	1.2
Locomotion velocity, session 2	1.4	1.7	2.7	-0.4	-0.5	-0.9	1.2	-1.6	1.5	1.6	1.6	1.6
Locomotion distance, session 2	0.5	0.7	2.0	1.4	1.4	1.0	-0.8	-0.3	-0.3	0.5	0.5	0.4
Locomotion velocity, session 3	0.3	0.3	0.7	-0.1	-0.3	-0.4	0.5	-0.9	0.6	0.6	0.6	0.7
Locomotion distance, session 3	0.4	0.4	1.1	0.4	0.3	-0.0	0.2	-1.1	0.5	0.8	0.8	0.8
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	-0.5	-0.3	-0.3	0.1	-0.6	-0.0	-0.2	-0.2	-0.2
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.5	-0.3	-0.3	0.0	-0.4	-0.1	-0.4	-0.4	-0.3
Locomotion velocity, session 7	0.3	0.3	1.1	0.3	-0.0	-0.2	0.3	-1.1	0.2	0.7	0.7	0.6
Locomotion distance, session 7	0.4	0.5	1.1	0.0	-0.2	-0.5	0.5	-0.9	0.5	1.0	1.0	0.9
Stereotopy head waving bouts, day 7	0.3	0.3	0.5	0.3	0.5	0.6	-0.6	0.0	-0.6	-0.7	-0.7	-0.7
Stereotopy head waving duration, day 7	0.3	0.4	0.5	0.4	0.6	0.6	-0.6	0.2	-0.6	-0.7	-0.7	-0.7
Locomotion velocity, session 8	1.1	1.3	3.2	-0.3	-0.4	-0.7	0.9	-1.8	1.1	1.4	1.4	1.4
Locomotion distance, session 8	0.4	0.5	1.4	0.2	0.2	-0.2	0.2	-1.2	0.6	1.0	1.0	1.0
Degree of sensitization distance	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.0	-0.0	-0.1	0.1	0.1	-0.0
Degree of sensitization stereotypy	0.2	0.2	0.4	0.1	0.3	0.3	-0.4	0.2	-0.3	-0.6	-0.6	-0.5
Conditioned locomotion	0.4	0.4	1.0	0.1	-0.0	-0.2	0.3	-1.0	0.7	0.8	0.8	0.9
Cocaine response after cond. corrected	0.7	1.0	2.9	-1.1	-1.2	-0.5	0.2	1.7	-0.5	-1.0	-1.0	-1.1
Cocaine response after cond. not corrected	0.9	1.3	2.8	0.4	0.4	0.7	-0.9	1.7	-1.4	-1.2	-1.2	-1.4
Cocaine response before conditioning	2.8	3.4	8.7	2.8	3.0	2.4	-2.2	-0.2	-1.8	-0.3	-0.3	-0.5
Saline control response	0.9	1.3	3.9	0.3	-0.0	-0.3	0.7	-2.0	0.9	1.5	1.5	1.4
Bone: connectivity density	0.0	0.0	0.1	0.1	-0.3	-0.1	0.3	0.0	0.1	0.1	0.1	0.1
Bone: cortical apparent density	0.2	0.4	0.8	0.2	-0.1	-0.2	0.6	0.2	0.6	0.9	0.9	0.9
Bone: cortical area	0.6	1.0	1.9	1.4	1.4	1.2	-1.3	0.1	-0.9	-0.7	-0.7	-0.6
Bone: cortical porosity	0.2	0.2	0.6	-0.5	-0.8	-0.5	0.5	-0.2	0.3	-0.3	-0.3	-0.1
Bone: cortical porosity	0.2	0.2	0.6	-0.1	-0.3	0.1	-0.1	0.3	-0.3	-0.8	-0.8	-0.6
Bone: cortical thickness	0.5	0.8	1.6	-0.7	-0.7	-0.9	1.0	-1.3	0.9	0.8	0.8	0.8
Bone: cortical thickness	0.1	0.1	0.2	0.2	0.2	-0.0	0.1	-0.1	0.3	0.5	0.5	0.4
Bone: cortical tissue density	0.2	0.3	0.7	0.2	-0.2	-0.2	0.6	0.3	0.5	0.9	0.9	0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.3	-0.5	-0.3	0.4	-0.2	0.2	0.1	0.1	0.1
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.8	-1.1	-1.3	-1.0	1.0	-0.1	0.7	0.2	0.2	0.2
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	0.3	0.4	-0.3	-0.1	-0.3	-0.1	-0.1	-0.2
Condit. Reinf. inactive responses	1.1	1.5	3.8	1.8	1.9	1.6	-1.5	-0.3	-1.1	-0.3	-0.3	-0.3
Incentive salience index mean	0.0	0.0	0.1	0.4	0.2	0.4	-0.2	0.1	-0.2	-0.0	-0.0	-0.1
Condit. Reinf. lever presses	0.4	0.5	1.1	1.0	1.0	1.0	-0.8	0.7	-0.6	-0.2	-0.2	-0.2
Condit. Reinf. active minus inactive responses	1.6	2.5	6.0	2.4	2.4	2.1	-2.0	0.4	-1.1	-0.6	-0.6	-0.4
Condit. Reinf. active-inactive response ratio	2.9	4.7	8.1	2.8	2.7	2.7	-2.6	1.7	-1.9	-1.5	-1.5	-1.3
Condit. Reinf. active responses	1.1	1.5	4.4	2.1	2.1	1.5	-1.4	-0.7	-0.5	0.2	0.2	0.3
Condit. Reinf. inactive responses	0.5	0.8	3.2	-0.1	-0.0	-0.5	0.5	-1.8	0.8	1.0	1.0	1.0
Condit. Reinf. lever presses	1.0	1.4	2.0	1.0	1.0	1.1	-1.4	0.7	-1.2	-1.4	-1.4	-1.2
Condit. Reinf. lever reinforcers received	1.4	2.0	5.7	2.4	2.3	1.8	-1.6	-0.6	-0.7	0.1	0.1	0.2
Conditioned reinforcement - actives	0.2	0.9	1.8	0.7	0.7	1.0	-1.0	1.4	-0.6	-1.0	-1.0	-0.8
Conditioned reinforcement - inactives	0.5	1.5	2.9	1.6	1.7	1.7	-1.5	1.1	-0.7	-0.5	-0.5	-0.3
Conditioned locomotion	0.3	0.4	1.4	0.5	0.5	0.6	-0.7	1.2	-0.3	-0.7	-0.7	-0.5
Patch foraging indifference point 0 sec	0.5	1.4	3.0	-0.6	-0.9	-1.0	1.1	-1.7	1.4	1.1	1.1	1.2
Patch foraging indifference point AUC	0.2	0.5	1.3	-1.2	-1.1	-1.0	0.9	-0.3	0.6	0.3	0.3	0.2
Delay disc. indifference point, 0s delay	0.7	0.8	1.5	-0.2	-0.3	-0.6	0.7	-1.2	1.0	1.1	1.1	1.1
Delay disc. indifference point, 16s delay	0.3	0.5	1.8	-0.6	-0.6	-0.2	0.0	1.3	-0.3	-0.8	-0.8	-0.8
Delay disc. indifference point, 2s delay	0.5	0.6	1.0	-0.6	-0.8	-0.8	0.9	-0.1	1.0	0.8	0.8	0.8
Delay disc. indifference point, 24s delay	0.2	0.3	1.1	-0.5	-0.7	-0.4	0.4	1.1	0.1	-0.3	-0.3	-0.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	0.5	0.4	0.5	-0.4	0.7	-0.3	-0.3	-0.3	-0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.4	-0.0	0.4	0.3	0.3	0.3
Indifference point function ln k	1.1	3.3	9.2	3.0	3.0	2.4	-2.2	-0.0	-1.1	-0.2	-0.2	-0.0
Indifference point function log k	1.1	3.3	9.2	3.0	3.0	2.4	-2.2	-0.0	-1.1	-0.2	-0.2	-0.0
Patch foraging total patch changes 0 sec	0.4	1.2	2.5	-0.6	-0.8	-1.0	1.0	-1.6	1.3	1.0	1.0	1.2
Patch foraging total patch changes 12 sec	0.1	0.1	0.5	-0.5	-0.7	-0.5	0.4	-0.1	0.3	-0.0	-0.0	0.0
Patch foraging total patch changes 18 sec	0.3	0.6	1.5	-0.8	-0.9	-0.9	0.9	-1.2	0.7	0.5	0.5	0.5
Patch foraging total patch changes 24 sec	0.1	0.3	1.0	0.2	-0.1	0.2	-0.3	1.0	-0.5	-0.8	-0.8	-0.7
Patch foraging total patch changes 6 sec	0.5	0.8	1.6	-1.2	-1.3	-1.1	1.0	-0.7	1.0	0.3	0.3	0.4
Patch foraging time to switch 0 sec	0.7	2.7	5.5	-1.5	-1.5	-0.4	0.1	2.3	-1.2	-2.0	-2.0	-2.1
Patch foraging water rate 0 sec	0.2	0.8	1.5	0.7	0.7	0.1	0.0	-1.2	0.7	1.1	1.1	1.2
Patch foraging water rate 12 sec	0.4	1.6	2.7	1.6	1.7	0.8	-0.5	-1.6	0.3	1.4	1.4	1.3
Patch foraging water rate 18 sec	0.4	0.9	1.6	1.0	0.9	0.3	-0.2	-1.3	0.6	1.1	1.1	1.2
Patch foraging water rate 24 sec	0.4	0.6	1.3	1.0	0.9	0.5	-0.3	-1.1	0.4	0.7	0.7	0.9
Patch foraging water rate 6 sec	3.1	4.6	10.2	3.2	3.1	2.8	-2.6	0.7	-1.8	-0.9	-0.9	-0.9
Seeking ratio, delayed vs. immediate footshock	0.8	1.1	2.9	-0.2	-0.1	-0.5	0.7	-1.7	1.0	1.3	1.3	1.3
Distance traveled before self-admin	0.7	1.4	2.9	1.3	1.1	0.4	-0.1	-1.7	0.6	1.4	1.4	1.4
Distance traveled after self-admin	1.3	2.3	4.3	-0.6	-0.8	-1.2	1.4	-2.1	1.6	1.8	1.8	1.8
Extensor digitorum longus weight	0.4	1.7	2.3	1.2	1.2	1.2	-1.5	1.1	-1.5	-1.3	-1.3	-1.3
Bone: elastic displacement	1.1	1.4	3.8	-1.1	-1.0	-1.2	1.1	-2.0	1.2	0.9	0.9	1.0
Bone: elastic work	0.2	0.2	0.9	0.4	0.7	0.3	-0.3	-1.0	0.1	0.2	0.2	0.3
Bone: endosteal estimation	2.5	6.2	9.3	2.8	2.9	2.9	-3.1	2.0	-2.5	-2.0	-2.0	-1.9
Bone: endosteal perimeter	1.3	3.2	5.3	2.3	2.3	2.1	-2.3	0.9	-1.7	-1.3	-1.3	-1.2
Epididymis fat weight	0.4	1.8	3.5	-0.0	0.3	0.7	-1.0	1.9	-1.4	-1.8	-1.8	-1.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.5	-0.3	-0.3	0.3	0.1	0.3	0.2	0.2	0.2
Delta time in open arm before/after self-admin	0.5	0.6	1.5	1.2	1.2	1.0	-0.8	-0.7	-0.5	0.0	0.0	0.0
Diff in mean of infusions in LGA sessions	0.3	0.5	1.3	0.1	0.0	-0.2	0.4	-1.1	0.7	0.9	0.9	0.9
Delay discount exponential model param	0.1	0.1	0.2	0.3	0.4	0.3	-0.4	-0.4	-0.4	-0.2	-0.2	-0.2
Extinction: sum of active levers before priming	0.3	0.4	0.5	-0.4	-0.5	-0.6	0.7	-0.6	0.7	0.7	0.7	0.7
Active lever presses in extinction session 6	1.2	1.2	3.4	0.0	0.1	0.5	-0.7	1.8	-1.0	-1.3	-1.3	-1.3
Bone: final force	1.5	2.4	4.4	2.0	2.1	1.9	-1.9	1.2	-1.4	-0.9	-0.9	-0.9
Bone: final moment	1.7	2.7	5.5	2.3	2.3	2.1	-2.1	1.0	-1.4	-0.9	-0.9	-0.8
Food consumed during 24 hour testing period	0.7	1.5	2.7	1.7	1.6	1.4	-1.5	0.4	-1.3	-0.7	-0.7	-0.8
Glucose	1.7	2.7	3.5	-1.8	-1.7	-1.9	1.9	-1.4	1.7	1.4	1.4	1.4
Heart weight	1.9	3.0	4.2	1.9	1.7	1.9	-1.9	1.5	-2.1	-1.5	-1.5	-1.6
Delay discount hyperbolic model param	0.1	0.2	0.3	0.3	0.5	0.4	-0.5	-0.3	-0.5	-0.3	-0.3	-0.3
Intermittent access intake day 1-15 change	0.1	0.8	1.1	1.0	1.0	1.1	-1.0	0.8	-1.0	-0.5	-0.5	-0.6
Intermittent access intake escalation	0.3	1.4	2.1	1.3	1.3	1.4	-1.4	1.2	-1.4	-0.9	-0.9	-0.9
Intermittent access intake escalation 2	0.1	0.1	0.3	0.2	0.2	0.1	0.1	-0.4	-0.1	0.6	0.6	0.4
Intermitt. access day 1 inactive lever presses	0.1	1.9	2.6	1.4	1.5	1.6	-1.6	1.4	-1.3	-1.2	-1.2	-1.1
Intermitt. access day 15 inactive lever presses	0.7	3.5	4.9	1.9	2.0	2.2	-2.2	2.0	-1.6	-1.7	-1.7	-1.4
Intermitt. access escalation Index	0.1	0.3	0.6	-0.8	-0.8	-0.6	0.6	0.4	0.5	0.2	0.2	0.2
Intermittent access day 1 total infusions	0.3	0.8	1.4	0.9	1.0	1.0	-1.1	1.2	-0.4	-0.9	-0.9	-0.5
Intermittent access day 15 total infusions	0.8	1.9	3.5	1.3	1.3	1.5	-1.6	1.9	-1.0	-1.3	-1.3	-1.0
Intermittent access terminal intake (last 3 days)	0.8	1.4	2.6	1.2	1.2	1.3	-1.3	1.6	-0.8	-1.0	-1.0	-0.7
Intermittent access total infusions	1.6	1.9	3.0	1.5	1.5	1.6	-1.6	1.7	-0.9	-1.2	-1.2	-0.9
Intermittent access day 1 locomotion	0.8	1.4	2.8	1.3	1.3	1.4	-1.4	1.7	-0.7	-1.0	-1.0	-0.6
Intermittent access day 15 total locomotion	0.2	0.7	1.9	1.3	1.4	1.1	-1.0	0.2	-0.1	-0.0	-0.0	0.3
Intermittent access total locomotion	2.4	2.8	4.7	2.1	2.2	2.1	-2.0	1.8	-1.3	-1.1	-1.1	-0.8
Intermittent access standard deviation	0.0	0.2	0.3	-0.4	-0.5	-0.6	0.5	-0.1	0.4	0.4	0.4	0.4
Left kidney weight	2.2	17.8	30.4	5.5	5.5	5.3	-5.1	2.2	-4.2	-2.8	-2.8	-2.7
Right kidney weight	2.9	19.9	30.2	5.3	5.5	5.4	-5.4	2.7	-4.6	-3.4	-3.4	-3.3
Cocaine induced anxiety	0.3	0.9	1.6	1.3	1.2	1.2	-1.1	0.2	-1.0	-0.5	-0.5	-0.6
Post-drug Anxiety	0.7	0.8	1.1	0.9	0.8	1.0	-1.0	0.6	-1.1	-0.9	-0.9	-0.9
Baseline Anxiety	0.2	0.4	1.1	-1.0	-0.9	-0.9	0.7	-0.1	0.4	0.2	0.2	0.2
Tail length	1.6	8.8	15.4	3.9	3.9	3.8	-3.6	1.7	-2.9	-1.8	-1.8	-1.8
Length with tail	2.8	12.6	18.2	4.2	4.2	4.3	-4.2	2.6	-3.8	-2.7	-2.7	-2.7
Length without tail	1.7	8.8	12.5	2.7	2.7	3.1	-3.2	2.8	-3.5	-2.8	-2.8	-3.0
Times rat made contact with spout	0.0	0.0	0.1	-0.0	-0.2	-0.1	-0.0	0.0	-0.1	-0.4	-0.4	-0.3
Lifetime Intake	1.1	1.3	2.3	1.2	1.2	1.3	-1.4	1.5	-0.7	-1.0	-1.0	-0.7
Liver weight, left	1.0	1.7	2.6	1.4	1.6	1.5	-1.5	0.8	-1.5	-1.0	-1.0	-1.1
Liver weight, right	0.0	0.1	0.1	0.1	0.2	0.2	-0.3	0.1	-0.3	-0.3	-0.3	-0.3
Locomotor activity	0.1	0.1	0.1	-0.4	-0.2	-0.1	-0.0	0.4	-0.1	-0.4	-0.4	-0.3
Locomotor testing distance	0.4	0.9	2.0	0.2	0.4	0.7	-0.8	1.4	-1.0	-1.1	-1.1	-1.1
Locomotor testing rearing	0.4	1.3	1.6	1.0	1.1	1.3	-1.2	1.3	-1.1	-1.2	-1.2	-1.1
Locomotion in novel chamber	0.5	0.6	1.2	-1.0	-1.1	-1.1	1.0	-0.4	0.7	0.5	0.5	0.4
Locomotion in novel chamber post-restriction	0.1	0.2	0.6	-0.8	-0.8	-0.6	0.5	0.4	0.3	-0.0	-0.0	-0.0
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	0.6	0.5	0.5	-0.4	0.2	-0.5	-0.0	-0.0	-0.1
Change in fecal boli incidents, locomotor task	2.2	2.3	3.8	-1.9	-1.9	-1.9	1.8	-0.8	1.6	1.1	1.1	1.1
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.2	-0.2	-0.0	0.0	0.3	-0.3	-0.2	-0.2	-0.3
Bouts of movement, locomotor time 1	0.8	1.0	3.3	0.1	0.1	-0.3	0.5	-1.8	0.8	1.3	1.3	1.3
Total resting periods, locomotor time 1	0.7	0.8	2.0	-0.2	-0.4	-0.6	0.7	-1.4	0.9	1.1	1.1	1.1
Rest time, locomotor task time 1	0.6	1.0	1.6	1.3	1.0	1.3	-1.2	1.0	-1.2	-0.6	-0.6	-0.7
Distance moved, locomotor task time 1	0.4	1.2	1.8	-1.3	-1.2	-1.3	1.2	-1.1	1.3	0.7	0.7	0.8
Vertical activity count, locomotor time 1	0.7	4.6	6.5	-2.0	-1.9	-2.3	2.3	-2.5	2.5	1.9	1.9	2.0
Time >=10cm from walls, locomotor time 2	0.1	0.4	1.1	-1.0	-1.0	-0.8	0.8	0.1	0.3	0.1	0.1	0.0
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.1	0.2	0.1	-0.1	0.2	-0.2	-0.1	-0.1	-0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	0.1	0.2	0.1	-0.1	0.1	-0.0	0.1	0.1	0.0
Rest time, locomotor task time 2	0.1	0.2	0.4	-0.0	-0.0	-0.2	0.3	-0.5	0.4	0.6	0.6	0.5
Distance moved, locomotor task time 2	0.1	0.2	0.4	-0.5	-0.4	-0.5	0.4	-0.5	0.6	0.2	0.2	0.4
Vertical activity count, locomotor time 2	0.1	0.3	0.7	-0.4	-0.3	-0.6	0.5	-0.8	0.8	0.5	0.5	0.6
Light reinforcement 1	0.5	2.1	4.3	-0.2	-0.5	-0.9	1.2	-2.1	1.3	1.9	1.9	1.7
Light reinforcement 2	1.1	2.6	3.3	-1.6	-1.7	-1.8	1.8	-1.5	1.6	1.5	1.5	1.4
Bone: marrow area	2.6	6.4	9.5	2.8	3.0	2.9	-3.1	2.0	-2.6	-2.0	-2.0	-1.9
Bone: maximum diameter	1.2	2.4	3.7	1.7	1.7	1.7	-1.9	0.8	-1.7	-1.4	-1.4	-1.4
Bone: maximum force	2.2	4.4	7.1	2.6	2.7	2.5	-2.6	1.3	-2.0	-1.5	-1.5	-1.5
Bone: maximum moment	2.4	4.6	8.1	2.8	2.9	2.6	-2.7	1.1	-2.0	-1.4	-1.4	-1.3
Mean time between licks in bursts	0.2	1.3	1.6	-1.2	-1.0	-1.3	1.2	-1.1	1.3	1.1	1.1	1.1
Mean num. licks in bursts	0.1	0.4	0.7	0.6	0.4	0.6	-0.7	0.8	-0.4	-0.7	-0.7	-0.5
Cd content in liver	1.0	1.1	2.9	1.7	1.6	1.4	-1.3	0.6	-0.9	-0.2	-0.2	-0.3
Co content in liver	0.4	0.5	1.0	1.0	0.7	0.5	0.0	-0.4	0.4	0.9	0.9	1.0
Cu content in liver	0.7	0.9	1.9	1.4	1.0	1.2	-0.9	0.8	-1.0	-0.6	-0.6	-0.6
Fe content in liver	0.2	0.2	0.6	0.8	0.6	0.6	-0.5	0.3	-0.3	-0.3	-0.3	-0.2
K content in liver	0.0	0.0	0.1	-0.0	-0.1	-0.0	0.1	-0.3	-0.2	0.1	0.1	-0.0
Mg content in liver	0.2	0.2	0.4	-0.1	-0.2	0.1	-0.1	0.5	-0.5	-0.7	-0.7	-0.7
Mn content in liver	0.2	0.2	0.5	0.1	-0.0	0.4	-0.2	0.3	-0.6	-0.7	-0.7	-0.7
Na content in liver	1.9	2.1	4.0	-1.7	-2.0	-1.8	1.9	-1.4	1.4	0.8	0.8	0.8
Rb content in liver	2.2	2.6	3.7	1.9	1.8	1.9	-1.9	0.8	-1.7	-1.4	-1.4	-1.3
Se content in liver	0.6	0.8	2.2	-1.4	-1.5	-1.2	0.9	-0.2	0.4	-0.3	-0.3	-0.3
Sr content in liver	7.6	6.6	8.3	-2.5	-2.6	-2.9	2.8	-2.6	2.8	2.2	2.2	2.2
Zn content in liver	0.5	0.6	1.8	-0.4	-0.6	-0.2	0.0	1.3	-0.5	-0.9	-0.9	-0.9
Bone: minimum diameter	2.3	4.4	7.9	2.7	2.8	2.6	-2.6	0.7	-2.1	-1.4	-1.4	-1.3
Time in familiar zone, hab. session 1	1.0	1.1	3.7	1.9	1.8	1.2	-1.0	-0.1	-0.5	0.5	0.5	0.4
Time in novel zone, hab. session 1	1.3	1.4	3.2	-1.8	-1.7	-1.6	1.4	-1.0	1.0	0.3	0.3	0.3
Total zone transitions, hab. session 1	1.3	1.8	3.5	0.7	0.6	-0.1	0.5	-1.9	1.3	1.8	1.8	1.9
Total locomotion distance, hab. session 1	1.0	1.4	2.7	0.3	0.2	-0.4	0.7	-1.6	1.2	1.6	1.6	1.6
Locomotion velocity, hab. session 1	0.7	0.9	1.8	0.2	0.1	-0.3	0.6	-1.2	1.0	1.3	1.3	1.4
Time in familiar zone, hab. session 2	3.8	4.4	5.4	2.0	2.0	2.3	-2.3	2.2	-2.3	-1.8	-1.8	-1.9
Time in novel zone, hab. session 2	2.0	2.1	3.0	-1.6	-1.6	-1.7	1.7	-1.5	1.5	1.1	1.1	1.1
Total zone transitions, hab. session 2	0.8	1.0	2.5	1.6	1.6	1.0	-0.8	-1.0	-0.1	0.6	0.6	0.6
Total locomotion distance, hab. session 2	0.6	0.8	1.8	0.0	-0.0	-0.5	0.6	-1.3	0.9	1.2	1.2	1.2
Locomotion velocity, hab. session 2	0.9	1.2	2.5	-0.1	-0.2	-0.7	0.8	-1.6	1.2	1.4	1.4	1.4
Novel to familiar place preference ratio	0.1	0.1	0.2	0.2	0.2	0.3	-0.3	0.3	-0.3	-0.4	-0.4	-0.4
Novelty place preference	0.1	0.2	0.2	0.4	0.4	0.4	-0.5	0.2	-0.4	-0.4	-0.4	-0.4
Time in novel zone, NPP test	0.2	0.2	0.3	0.5	0.5	0.5	-0.5	0.4	-0.5	-0.5	-0.5	-0.5
Total zone transitions, NPP test	0.2	0.3	0.7	0.5	0.5	0.1	0.0	-0.8	0.4	0.7	0.7	0.8
Total locomotion distance, NPP test	0.1	0.2	0.4	0.6	0.6	0.5	-0.5	-0.3	-0.3	-0.1	-0.1	-0.0
Locomotion velocity, NPP test	0.1	0.2	0.5	0.6	0.6	0.4	-0.3	-0.7	-0.0	0.3	0.3	0.3
Intraocular pressure	0.1	0.2	0.4	-0.3	-0.3	-0.4	0.5	-0.7	0.5	0.6	0.6	0.5
Delta distance traveled before/after self-admin	1.0	1.1	2.4	-1.4	-1.6	-1.3	1.3	-0.6	0.9	0.4	0.4	0.4
Delta ambulatory time before/after self-admin	0.6	1.0	2.0	-1.3	-1.4	-1.3	1.2	-0.7	0.9	0.5	0.5	0.5
Parametrial fat weight	0.8	1.9	5.0	-2.2	-2.0	-1.8	1.5	-0.3	1.4	0.2	0.2	0.4
Pavlov. Cond. lever latency	0.2	0.3	0.6	-0.2	-0.5	-0.6	0.5	-0.8	0.4	0.5	0.5	0.5
Pavlov. Cond. magazine entry latency	0.3	0.4	1.0	-1.0	-0.9	-0.6	0.4	0.7	-0.2	-0.3	-0.3	-0.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	-0.5	-0.5	-0.4	0.5	0.1	0.4	0.3	0.3	0.2
Pavlov. Cond. index score	0.1	0.1	0.4	-0.6	-0.5	-0.4	0.4	0.5	0.1	0.0	0.0	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.5	-0.5	-0.4	-0.2	0.3	0.7	0.0	-0.1	-0.1	-0.2
Pavlov. Cond. lever contacts	0.6	0.7	1.3	0.3	0.5	0.8	-0.8	1.2	-0.8	-0.9	-0.9	-0.9
Pavlov. Cond. magazine entry number	0.1	0.2	0.5	0.5	0.5	0.3	-0.2	-0.7	0.2	0.3	0.3	0.4
Pavlov. Cond. intertrial magazine entries	2.0	2.5	6.9	-0.3	-0.3	-0.9	1.2	-2.6	1.7	1.8	1.8	1.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	-0.6	-0.5	-0.4	0.4	0.5	0.0	-0.0	-0.0	-0.1
Pavlov. Cond. response bias	0.4	0.5	1.5	-0.0	0.0	0.3	-0.4	1.2	-0.7	-0.8	-0.8	-0.9
Pavlov. Cond. lever latency	0.3	0.4	0.9	0.8	0.7	0.8	-0.5	1.0	-0.9	-0.2	-0.2	-0.4
Pavlov. Cond. magazine entry latency	0.3	0.5	1.6	-1.3	-1.1	-0.8	0.5	-0.2	0.4	-0.2	-0.2	-0.1
Pavlov. Cond. change in total contacts	0.1	0.2	1.1	0.3	0.4	0.1	-0.2	-1.1	0.5	0.2	0.2	0.4
Pavlov. Cond. index score	0.1	0.1	0.2	-0.4	-0.3	-0.3	-0.0	-0.4	0.3	-0.3	-0.3	-0.1
Pavlov. Cond. latency score	0.2	0.3	0.8	-0.9	-0.7	-0.7	0.3	-0.5	0.5	-0.2	-0.2	-0.0
Pavlov. Cond. lever contacts	0.1	0.2	0.6	-0.5	-0.3	-0.5	0.2	-0.8	0.5	-0.0	-0.0	0.2
Pavlov. Cond. magazine entry number	0.2	0.3	0.8	0.9	0.8	0.7	-0.4	0.1	-0.5	0.1	0.1	-0.1
Pavlov. Cond. intertrial magazine entries	0.9	2.0	5.0	2.2	2.2	1.8	-1.7	0.4	-1.3	-0.3	-0.3	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	-0.6	-0.4	-0.5	0.1	-0.4	0.5	-0.1	-0.1	0.1
Pavlov. Cond. response bias	0.1	0.1	0.3	0.1	0.3	0.1	-0.4	-0.5	0.1	-0.3	-0.3	-0.0
Time in closed arm before self-admin	0.4	0.6	1.5	1.2	1.0	1.0	-0.9	0.0	-0.8	-0.4	-0.4	-0.4
Time in closed arm after self-admin	0.2	0.3	0.3	0.4	0.3	0.5	-0.5	0.5	-0.6	-0.6	-0.6	-0.6
Time in open arm before self-admin	1.1	1.3	3.0	-1.7	-1.6	-1.5	1.4	-0.3	1.1	0.5	0.5	0.5
Time in open arm after self-admin	0.4	0.5	0.7	-0.7	-0.5	-0.7	0.7	-0.9	0.8	0.7	0.7	0.7
Bone: periosteal estimation	1.7	4.1	6.6	2.5	2.6	2.4	-2.6	1.1	-2.0	-1.5	-1.5	-1.4
Bone: periosteal perimeter	1.1	2.1	4.2	2.0	2.0	1.8	-1.9	0.3	-1.3	-0.9	-0.9	-0.8
Bone: post-yield work	3.4	5.8	7.5	2.7	2.5	2.7	-2.7	2.0	-2.5	-2.1	-2.1	-2.0
Progressive ratio test 1 active lever presses	0.1	0.3	0.7	0.8	0.8	0.6	-0.5	-0.4	0.2	0.2	0.2	0.4
Progressive ratio test 1 breakpoint	0.1	0.3	0.7	0.8	0.8	0.6	-0.5	-0.4	0.2	0.2	0.2	0.4
Progressive ratio test 1 inactive lever presses	0.6	1.7	3.6	1.8	1.9	1.8	-1.6	0.8	-0.7	-0.6	-0.6	-0.4
Progressive ratio test 2 active lever presses	0.9	1.2	1.7	0.9	1.0	1.2	-1.2	1.3	-0.9	-1.2	-1.2	-1.0
Progressive ratio test 2 breakpoint	1.1	1.4	1.8	1.0	1.1	1.3	-1.4	1.4	-1.0	-1.3	-1.3	-1.0
Progressive ratio test 2 inactive lever presses	0.9	2.8	5.1	2.2	2.3	2.2	-2.1	1.2	-1.2	-1.1	-1.1	-0.8
Incentive Sensitization - Responses	1.2	3.2	4.1	1.6	1.6	2.0	-2.0	1.9	-1.7	-1.8	-1.8	-1.6
Incentive Sensitization - Breakpoint	1.2	2.7	3.5	1.3	1.4	1.8	-1.8	1.9	-1.6	-1.7	-1.7	-1.6
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	-0.1	-0.3	-0.4	0.5	-0.7	0.6	0.7	0.7	0.7
Progressive ratio	0.2	0.5	1.6	-0.2	-0.2	-0.5	0.5	-1.3	0.5	0.8	0.8	0.7
Food seeking constrained by brief footshock	6.0	7.5	19.5	-0.6	-0.5	-1.6	2.0	-4.4	2.6	3.4	3.4	3.3
Seeking ratio, punishment vs. effort	0.1	0.2	0.5	0.7	0.7	0.4	-0.2	-0.5	0.1	0.5	0.5	0.5
Retroperitoneal fat weight	1.4	6.1	18.4	-4.3	-4.0	-3.3	2.6	0.7	1.6	-0.3	-0.3	-0.2
Reaction time number correct	0.1	0.5	1.5	-0.7	-0.5	-0.7	0.6	-0.4	1.2	0.6	0.6	0.9
Reaction time mean minus median	0.0	0.3	1.3	0.1	0.2	0.3	-0.3	1.2	-0.6	-0.3	-0.3	-0.5
Reaction time mean minus median AUC	0.0	0.3	1.3	-0.1	0.1	0.3	-0.3	1.2	-0.7	-0.5	-0.5	-0.6
Reaction time num false alarms	0.0	0.0	0.1	0.4	0.1	0.1	-0.1	0.2	-0.0	-0.1	-0.1	-0.0
Reaction time num false alarms AUC	0.1	0.3	0.5	-0.2	-0.4	-0.5	0.7	-0.6	0.6	0.7	0.7	0.7
Reaction time trials correct on left	0.1	0.5	1.5	-0.7	-0.5	-0.7	0.6	-0.4	1.2	0.6	0.6	0.9
Reaction time trials on left	0.2	0.5	1.5	-0.7	-0.5	-0.7	0.6	-0.4	1.2	0.6	0.6	0.9
Reaction time mean	0.9	2.1	3.7	1.2	1.2	1.5	-1.5	1.9	-1.7	-1.2	-1.2	-1.4
Reaction time mean AUC	0.8	1.8	4.3	0.8	0.9	1.2	-1.2	2.1	-1.6	-1.3	-1.3	-1.4
Median of all reaction times	1.2	1.9	3.0	1.2	1.2	1.4	-1.4	1.7	-1.6	-1.2	-1.2	-1.3
Reaction time omissions	0.2	0.3	0.6	-0.1	-0.2	-0.4	0.5	-0.6	0.5	0.8	0.8	0.7
Reaction time false alarm rate	0.1	0.1	0.3	0.2	-0.1	-0.2	0.4	-0.5	0.1	0.4	0.4	0.3
Reaction time premature initiation rate	0.3	0.4	0.9	0.7	0.2	0.4	-0.3	0.9	-0.9	-0.7	-0.7	-0.8
Reaction time premature initiations	0.1	0.2	0.6	0.2	-0.1	0.0	-0.0	0.8	-0.4	-0.5	-0.5	-0.5
Std. dev. reaction times	0.5	1.7	3.8	1.0	1.0	1.3	-1.2	2.0	-1.5	-1.1	-1.1	-1.2
Reaction time trials completed	0.2	0.5	1.5	-0.7	-0.5	-0.7	0.6	-0.4	1.2	0.6	0.6	0.9
Reaction time trials AUC	0.1	0.3	1.0	-0.5	-0.4	-0.6	0.4	-0.1	1.0	0.3	0.3	0.6
Run reversals in cocaine runway, females	0.7	0.7	0.8	0.8	0.7	0.9	-0.9	0.9	-0.9	-0.9	-0.9	-0.8
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.1	0.2	0.3	-0.3	0.4	-0.1	-0.4	-0.4	-0.2
Latency to leave start box in cocaine runway	0.2	0.3	0.6	0.5	0.8	0.5	-0.6	0.7	-0.6	-0.2	-0.2	-0.3
Latency to leave start box in cocaine runway, F	0.0	0.1	0.3	-0.0	0.2	0.0	-0.1	0.6	-0.3	-0.0	-0.0	-0.2
Latency to leave start box in cocaine runway, M	1.0	1.0	1.7	1.3	1.3	1.3	-1.2	0.7	-1.0	-0.6	-0.6	-0.6
Std. dev. time between licks in bursts	1.4	2.6	5.3	-0.7	-0.5	-1.2	1.4	-2.3	1.5	2.0	2.0	1.9
Total sessions with >9 infusions	0.5	0.6	1.3	1.1	1.1	1.1	-0.9	0.5	-0.4	-0.3	-0.3	-0.2
Short access day 1 total inactive lever presses	0.9	1.7	2.3	1.2	1.2	1.4	-1.4	1.5	-1.2	-1.3	-1.3	-1.2
Short access day 10 total inactive lever presses	0.0	0.2	0.4	0.5	0.5	0.5	-0.5	0.6	-0.3	-0.3	-0.3	-0.3
Short access day 1 total infusions	0.0	0.0	0.1	0.0	0.0	0.1	-0.1	0.2	0.4	-0.0	-0.0	0.2
Short access day 10 total infusions	0.0	0.1	0.4	-0.1	-0.1	-0.2	0.1	0.1	0.6	0.1	0.1	0.4
Short access total infusions	0.1	0.1	0.2	-0.3	-0.2	-0.2	0.2	0.5	0.5	0.0	0.0	0.2
Short access day 1 locomotion	0.6	1.0	2.1	0.8	0.8	1.1	-1.0	1.4	-1.1	-0.9	-0.9	-0.9
Short access day 10 total locomotion	0.1	0.4	0.7	0.8	0.8	0.4	-0.3	-0.5	0.5	0.7	0.7	0.8
Short access total locomotion	0.2	0.3	0.8	0.3	0.4	0.1	0.1	-0.4	0.6	0.8	0.8	0.9
One hour access (0.3 mA shock)	3.2	3.8	6.2	2.4	2.4	2.5	-2.4	1.7	-1.6	-1.5	-1.5	-1.2
Compulsive drug intake	0.8	1.2	2.4	1.5	1.6	1.5	-1.5	0.3	-0.4	-0.8	-0.8	-0.4
One hour access (shock baseline)	0.4	1.1	3.1	0.7	0.7	0.9	-1.0	1.8	-0.9	-1.1	-1.1	-1.0
Social response proportion	1.5	1.9	3.4	1.3	1.1	1.4	-1.4	1.8	-1.2	-1.4	-1.4	-1.2
Social responses	2.0	2.6	4.9	2.2	2.0	2.0	-1.9	0.9	-1.6	-1.0	-1.0	-1.0
Social time	0.9	1.5	4.6	2.2	2.0	1.4	-1.0	-0.8	-0.2	0.5	0.5	0.6
Soleus weight	0.1	0.3	0.4	0.5	0.3	0.5	-0.5	0.6	-0.6	-0.4	-0.4	-0.5
Bone: stiffness	1.8	3.4	5.4	2.3	2.3	2.2	-2.2	1.3	-1.8	-1.3	-1.3	-1.2
Tibialis anterior weight	0.2	0.7	1.6	-1.3	-1.3	-1.0	0.4	0.6	0.0	-0.7	-0.7	-0.7
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.7	0.4	0.5	0.2	-0.1	-0.8	0.2	0.5	0.5	0.5
Time to tail flick, vehicle, after self-admin	0.6	1.2	3.2	1.0	0.7	1.0	-1.0	1.8	-1.1	-0.9	-0.9	-0.9
Time to tail flick, test, before self-admin	1.2	1.4	2.7	-0.3	-0.4	-0.8	1.0	-1.7	1.3	1.5	1.5	1.5
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.4	-0.5	-0.4	0.3	0.1	0.1	-0.1	-0.1	-0.1
Delta time to tail flick, vehicle, before/after SA	0.7	0.8	3.6	0.2	0.1	0.4	-0.5	1.9	-0.7	-0.9	-0.9	-0.9
Delta time to tail flick, test, before/after SA	0.6	0.7	1.1	0.3	0.3	0.6	-0.7	1.0	-0.9	-1.0	-1.0	-1.0
Tibia length	3.0	8.3	12.0	3.5	3.5	3.4	-3.5	1.8	-2.9	-2.3	-2.3	-2.2
Ambulatory time before self-admin	0.3	1.0	1.9	1.4	1.1	0.6	-0.3	-1.3	0.3	1.0	1.0	1.0
Ambulatory time after self-admin	1.0	1.5	4.2	0.1	-0.1	-0.6	0.8	-2.0	1.2	1.5	1.5	1.5
Bone: tissue strength	0.5	0.6	1.3	0.3	0.3	-0.1	0.3	-0.7	0.7	1.1	1.1	1.1
Total heroin consumption	0.1	0.2	0.2	-0.3	-0.3	-0.4	0.4	-0.5	0.4	0.4	0.4	0.4
Bone: trabecular number	0.1	0.2	0.4	-0.4	-0.5	-0.5	0.7	-0.2	0.5	0.4	0.4	0.4
Bone: trabecular spacing	0.0	0.1	0.1	-0.2	0.1	0.1	-0.3	0.0	-0.3	-0.3	-0.3	-0.3
Bone: trabecular thickness	0.0	0.1	0.2	0.1	0.0	0.1	-0.1	0.5	-0.1	-0.3	-0.3	-0.2
Bone: trabecular tissue density	0.3	0.5	1.1	-1.0	-1.0	-0.6	0.4	0.6	-0.2	-0.6	-0.6	-0.7
Water consumed over 24 hours	0.2	0.4	1.5	1.2	1.1	0.7	-0.7	-0.3	-0.4	0.1	0.1	0.0
Number of responses in last shaping day	0.4	0.5	2.1	0.1	0.1	0.3	-0.4	1.4	-0.9	-0.6	-0.6	-0.8