Hub : Genes

LOC134482148

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression LOC134482148 0.16 0.09 2.2e-10 0.08 0.08 0.08 0.09 4.5e-09 3.0e-09 4.8e-09 8.1e-10
2 Liver gene expression LOC134482148 0.05 0.04 9.9e-04 0.03 0.02 0.01 0.02 4.3e-04 4.1e-03 1.4e-02 2.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.00.00.00.1-0.1
Area under the delay curve0.00.00.0-0.10.1
BMI with tail0.10.30.30.5-0.5
BMI without tail0.10.40.40.7-0.7
Body weight0.10.30.30.5-0.5
Weight adjusted by age0.41.11.1-1.01.0
Bone surface0.00.00.0-0.00.0
Bone volume0.00.00.0-0.20.2
Breakpoint value in progressive ratio session1.22.22.2-1.51.5
Number of licking bursts0.20.70.70.8-0.8
Context. condit. distance diff. score1.62.02.01.4-1.4
Locomotion velocity, session 11.82.02.0-1.41.4
Locomotion distance, session 10.20.20.2-0.50.5
Locomotion velocity, session 20.10.10.1-0.30.3
Locomotion distance, session 20.71.01.0-1.01.0
Locomotion velocity, session 30.10.10.10.3-0.3
Locomotion distance, session 30.50.60.60.8-0.8
Stereotopy head waving bouts, day 30.91.11.1-1.11.0
Stereotopy head waving duration, day 31.72.12.1-1.41.4
Locomotion velocity, session 76.26.86.82.6-2.6
Locomotion distance, session 73.14.04.02.0-2.0
Stereotopy head waving bouts, day 70.10.20.2-0.40.4
Stereotopy head waving duration, day 70.40.50.5-0.70.7
Locomotion velocity, session 80.10.10.10.4-0.4
Locomotion distance, session 80.60.90.90.9-0.9
Degree of sensitization distance1.01.11.11.1-1.0
Degree of sensitization stereotypy0.00.00.0-0.10.1
Conditioned locomotion0.00.00.00.2-0.2
Cocaine response after cond. corrected0.50.80.8-0.90.9
Cocaine response after cond. not corrected0.10.10.1-0.30.3
Cocaine response before conditioning1.72.02.01.4-1.4
Saline control response0.00.00.00.2-0.2
Bone: connectivity density0.50.90.90.9-0.9
Bone: cortical apparent density0.00.00.00.2-0.2
Bone: cortical area0.00.00.00.1-0.1
Bone: cortical porosity0.30.30.30.5-0.6
Bone: cortical porosity0.10.10.10.3-0.3
Bone: cortical thickness0.20.40.40.6-0.6
Bone: cortical thickness0.10.10.10.3-0.3
Bone: cortical tissue density0.00.10.10.2-0.2
Condit. Reinf. active minus inactive responses0.10.10.10.2-0.2
Condit. Reinf. active-inactive response ratio0.30.30.3-0.60.5
Condit. Reinf. active responses0.70.90.91.0-1.0
Condit. Reinf. inactive responses1.62.12.21.5-1.4
Incentive salience index mean1.41.71.81.3-1.3
Condit. Reinf. lever presses3.24.84.82.2-2.2
Condit. Reinf. active minus inactive responses0.40.70.70.8-0.8
Condit. Reinf. active-inactive response ratio0.10.20.20.4-0.4
Condit. Reinf. active responses0.91.31.31.1-1.1
Condit. Reinf. inactive responses0.91.41.41.2-1.2
Condit. Reinf. lever presses0.91.31.31.1-1.1
Condit. Reinf. lever reinforcers received1.21.61.61.3-1.3
Conditioned reinforcement - actives0.00.10.10.3-0.2
Conditioned reinforcement - inactives1.13.13.11.8-1.8
Conditioned locomotion0.10.20.2-0.50.5
Patch foraging indifference point 0 sec1.74.95.02.2-2.2
Patch foraging indifference point AUC0.20.60.6-0.80.7
Delay disc. indifference point, 0s delay0.10.10.1-0.20.3
Delay disc. indifference point, 16s delay0.10.10.1-0.30.4
Delay disc. indifference point, 2s delay1.01.11.1-1.01.0
Delay disc. indifference point, 24s delay0.00.00.0-0.20.2
Delay disc. indifference point, 4s delay0.40.50.5-0.70.7
Delay disc. indifference point, 8s delay0.20.30.30.6-0.6
Indifference point function ln k0.61.71.81.3-1.3
Indifference point function log k0.61.71.81.3-1.3
Patch foraging total patch changes 0 sec1.44.04.02.0-2.0
Patch foraging total patch changes 12 sec0.30.40.40.6-0.6
Patch foraging total patch changes 18 sec0.20.50.50.7-0.7
Patch foraging total patch changes 24 sec0.10.50.50.7-0.7
Patch foraging total patch changes 6 sec1.83.13.11.7-1.7
Patch foraging time to switch 0 sec0.00.00.0-0.20.2
Patch foraging water rate 0 sec0.10.40.40.6-0.6
Patch foraging water rate 12 sec0.00.00.00.1-0.1
Patch foraging water rate 18 sec0.00.00.00.1-0.1
Patch foraging water rate 24 sec0.20.30.30.6-0.6
Patch foraging water rate 6 sec0.71.01.0-1.01.0
Seeking ratio, delayed vs. immediate footshock0.20.20.20.5-0.5
Distance traveled before self-admin1.53.23.2-1.81.8
Distance traveled after self-admin2.03.63.6-1.91.9
Extensor digitorum longus weight7.630.530.8-5.65.5
Bone: elastic displacement0.30.40.4-0.60.6
Bone: elastic work0.50.60.6-0.80.8
Bone: endosteal estimation0.00.10.1-0.30.3
Bone: endosteal perimeter0.10.20.2-0.40.4
Epididymis fat weight0.41.91.91.4-1.4
Delta time in closed arm before/after self-admin1.41.31.31.2-1.1
Delta time in open arm before/after self-admin0.00.00.0-0.20.2
Diff in mean of infusions in LGA sessions0.50.91.0-1.01.0
Delay discount exponential model param0.00.00.00.2-0.2
Extinction: sum of active levers before priming0.10.10.10.3-0.3
Active lever presses in extinction session 60.40.40.40.6-0.6
Bone: final force0.91.51.51.2-1.2
Bone: final moment0.71.11.11.0-1.0
Food consumed during 24 hour testing period0.00.10.10.3-0.3
Glucose0.00.00.0-0.20.1
Heart weight0.10.20.20.5-0.5
Delay discount hyperbolic model param0.10.10.10.3-0.3
Intermittent access intake day 1-15 change0.63.23.21.8-1.8
Intermittent access intake escalation0.74.04.02.0-2.0
Intermittent access intake escalation 21.32.12.21.5-1.5
Intermitt. access day 1 inactive lever presses0.11.21.21.1-1.1
Intermitt. access day 15 inactive lever presses0.21.31.31.1-1.1
Intermitt. access escalation Index0.10.20.2-0.40.4
Intermittent access day 1 total infusions0.10.20.20.4-0.4
Intermittent access day 15 total infusions1.33.23.21.8-1.8
Intermittent access terminal intake (last 3 days)1.22.02.01.4-1.4
Intermittent access total infusions1.82.12.11.5-1.5
Intermittent access day 1 locomotion0.91.61.61.3-1.3
Intermittent access day 15 total locomotion0.10.50.50.7-0.7
Intermittent access total locomotion1.01.11.21.1-1.1
Intermittent access standard deviation0.10.50.5-0.70.7
Left kidney weight0.53.83.82.0-2.0
Right kidney weight0.21.61.61.3-1.3
Cocaine induced anxiety0.10.30.3-0.50.5
Post-drug Anxiety0.20.20.20.5-0.5
Baseline Anxiety1.32.12.21.5-1.5
Tail length0.10.70.70.8-0.9
Length with tail0.00.00.00.0-0.1
Length without tail0.31.61.6-1.31.2
Times rat made contact with spout2.63.03.01.7-1.7
Lifetime Intake1.11.31.41.2-1.2
Liver weight, left0.50.91.0-1.01.0
Liver weight, right1.11.91.9-1.41.4
Locomotor activity3.35.15.2-2.32.2
Locomotor testing distance0.61.41.4-1.21.2
Locomotor testing rearing0.20.70.7-0.80.8
Locomotion in novel chamber0.00.10.10.2-0.2
Locomotion in novel chamber post-restriction0.20.50.5-0.70.7
Fecal boli incidents, locomotor time 10.40.91.0-1.01.0
Change in fecal boli incidents, locomotor task0.10.10.1-0.30.3
Time >=10cm from walls, locomotor time 10.60.80.80.9-0.9
Bouts of movement, locomotor time 10.50.60.7-0.80.8
Total resting periods, locomotor time 10.70.90.9-0.90.9
Rest time, locomotor task time 11.11.81.8-1.31.3
Distance moved, locomotor task time 11.02.72.81.7-1.6
Vertical activity count, locomotor time 10.00.20.2-0.40.5
Time >=10cm from walls, locomotor time 20.71.91.9-1.41.4
Bouts of movement, locomotor time 20.62.12.2-1.51.4
Total resting periods, locomotor time 20.52.02.0-1.41.4
Rest time, locomotor task time 20.61.01.0-1.01.0
Distance moved, locomotor task time 21.11.41.51.2-1.2
Vertical activity count, locomotor time 20.51.21.2-1.11.1
Light reinforcement 10.94.24.32.1-2.0
Light reinforcement 20.71.51.61.2-1.2
Bone: marrow area0.00.10.1-0.20.2
Bone: maximum diameter0.10.20.2-0.50.5
Bone: maximum force0.10.20.20.4-0.4
Bone: maximum moment0.00.10.10.2-0.3
Mean time between licks in bursts0.10.40.40.6-0.6
Mean num. licks in bursts0.00.00.00.2-0.2
Cd content in liver2.62.92.9-1.71.7
Co content in liver4.65.45.5-2.32.3
Cu content in liver0.20.30.3-0.50.5
Fe content in liver0.70.90.91.0-1.0
K content in liver3.33.23.21.8-1.8
Mg content in liver0.80.90.91.0-1.0
Mn content in liver0.10.10.1-0.30.3
Na content in liver0.10.10.1-0.30.3
Rb content in liver0.00.00.00.1-0.1
Se content in liver1.21.41.4-1.21.2
Sr content in liver1.21.11.1-1.01.0
Zn content in liver0.40.40.4-0.70.7
Bone: minimum diameter0.00.00.0-0.20.2
Time in familiar zone, hab. session 11.01.11.11.1-1.1
Time in novel zone, hab. session 14.04.44.5-2.12.1
Total zone transitions, hab. session 10.50.70.7-0.80.8
Total locomotion distance, hab. session 10.10.10.1-0.40.4
Locomotion velocity, hab. session 10.00.00.0-0.20.2
Time in familiar zone, hab. session 20.80.90.9-0.90.9
Time in novel zone, hab. session 20.00.00.0-0.0-0.0
Total zone transitions, hab. session 21.72.12.1-1.51.4
Total locomotion distance, hab. session 20.81.01.0-1.01.0
Locomotion velocity, hab. session 21.21.61.6-1.31.2
Novel to familiar place preference ratio0.40.50.50.7-0.7
Novelty place preference0.50.60.60.8-0.8
Time in novel zone, NPP test0.30.30.30.6-0.6
Total zone transitions, NPP test0.00.00.0-0.20.2
Total locomotion distance, NPP test0.10.20.20.4-0.4
Locomotion velocity, NPP test0.30.40.50.7-0.7
Intraocular pressure0.40.60.60.8-0.8
Delta distance traveled before/after self-admin0.30.30.3-0.60.5
Delta ambulatory time before/after self-admin0.20.40.4-0.70.6
Parametrial fat weight1.33.03.01.7-1.7
Pavlov. Cond. lever latency2.12.62.7-1.61.6
Pavlov. Cond. magazine entry latency1.01.31.31.2-1.1
Pavlov. Cond. change in total contacts0.50.50.50.7-0.7
Pavlov. Cond. index score2.22.72.81.7-1.6
Pavlov. Cond. latency score3.03.83.82.0-1.9
Pavlov. Cond. lever contacts3.23.83.82.0-1.9
Pavlov. Cond. magazine entry number0.30.40.4-0.70.7
Pavlov. Cond. intertrial magazine entries0.50.60.60.8-0.8
Pavlov. Cond. lever-magazine prob. diff.1.72.12.11.5-1.4
Pavlov. Cond. response bias0.81.01.01.0-1.0
Pavlov. Cond. lever latency0.00.00.0-0.00.0
Pavlov. Cond. magazine entry latency0.10.10.10.3-0.3
Pavlov. Cond. change in total contacts0.61.51.5-1.21.2
Pavlov. Cond. index score0.10.10.1-0.30.3
Pavlov. Cond. latency score0.00.00.0-0.20.2
Pavlov. Cond. lever contacts0.00.00.00.00.0
Pavlov. Cond. magazine entry number0.10.10.1-0.30.3
Pavlov. Cond. intertrial magazine entries2.96.36.32.5-2.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.30.3
Pavlov. Cond. response bias0.00.00.0-0.20.2
Time in closed arm before self-admin0.00.00.00.2-0.2
Time in closed arm after self-admin0.20.20.20.4-0.4
Time in open arm before self-admin0.40.50.5-0.70.7
Time in open arm after self-admin0.20.20.3-0.50.5
Bone: periosteal estimation0.00.10.1-0.20.2
Bone: periosteal perimeter0.00.10.1-0.30.3
Bone: post-yield work0.30.50.50.7-0.7
Progressive ratio test 1 active lever presses0.10.10.10.3-0.3
Progressive ratio test 1 breakpoint0.00.00.00.2-0.2
Progressive ratio test 1 inactive lever presses1.02.52.51.6-1.6
Progressive ratio test 2 active lever presses0.40.60.70.8-0.8
Progressive ratio test 2 breakpoint0.50.60.60.8-0.8
Progressive ratio test 2 inactive lever presses0.51.71.71.3-1.3
Incentive Sensitization - Responses0.30.70.70.8-0.8
Incentive Sensitization - Breakpoint0.40.90.90.9-1.0
Sum of active levers in priming session hrs 5-60.40.40.4-0.60.6
Progressive ratio0.20.70.7-0.80.8
Food seeking constrained by brief footshock5.67.17.2-2.62.7
Seeking ratio, punishment vs. effort0.10.30.3-0.50.5
Retroperitoneal fat weight0.83.73.82.0-1.9
Reaction time number correct0.41.41.4-1.21.2
Reaction time mean minus median0.10.60.6-0.80.8
Reaction time mean minus median AUC0.00.10.1-0.30.3
Reaction time num false alarms0.00.10.10.3-0.3
Reaction time num false alarms AUC0.10.30.30.5-0.5
Reaction time trials correct on left0.41.41.4-1.21.2
Reaction time trials on left0.41.21.2-1.11.1
Reaction time mean0.10.20.2-0.50.5
Reaction time mean AUC0.30.60.6-0.80.8
Median of all reaction times0.10.10.1-0.30.3
Reaction time omissions0.10.20.20.5-0.4
Reaction time false alarm rate0.81.21.21.1-1.1
Reaction time premature initiation rate0.00.10.1-0.30.2
Reaction time premature initiations0.20.70.7-0.80.8
Std. dev. reaction times0.20.60.6-0.80.8
Reaction time trials completed0.41.21.2-1.11.1
Reaction time trials AUC0.41.31.3-1.21.1
Run reversals in cocaine runway, females0.10.10.10.3-0.3
Run reversals in cocaine runway, males1.01.21.2-1.11.1
Latency to leave start box in cocaine runway1.52.02.0-1.41.4
Latency to leave start box in cocaine runway, F1.51.81.9-1.41.3
Latency to leave start box in cocaine runway, M1.01.01.0-1.01.0
Std. dev. time between licks in bursts0.71.31.31.1-1.2
Total sessions with >9 infusions0.10.20.20.4-0.4
Short access day 1 total inactive lever presses0.20.40.40.7-0.7
Short access day 10 total inactive lever presses0.10.40.40.6-0.6
Short access day 1 total infusions0.10.10.10.3-0.3
Short access day 10 total infusions0.20.30.3-0.60.6
Short access total infusions0.00.00.00.1-0.1
Short access day 1 locomotion0.30.50.5-0.70.7
Short access day 10 total locomotion0.00.10.20.4-0.4
Short access total locomotion0.00.00.00.2-0.2
One hour access (0.3 mA shock)0.10.10.10.3-0.3
Compulsive drug intake1.21.81.81.3-1.3
One hour access (shock baseline)0.20.50.6-0.70.8
Social response proportion0.10.10.1-0.40.4
Social responses0.30.40.40.7-0.7
Social time0.10.20.20.5-0.5
Soleus weight5.315.515.5-3.93.9
Bone: stiffness0.50.90.90.9-0.9
Tibialis anterior weight5.117.517.6-4.24.2
Time to tail flick, vehicle, before self-admin1.72.22.21.5-1.5
Time to tail flick, vehicle, after self-admin0.30.70.7-0.80.8
Time to tail flick, test, before self-admin1.51.71.81.3-1.3
Time to tail flick, test, after self-admin3.03.13.11.8-1.8
Delta time to tail flick, vehicle, before/after SA0.60.70.7-0.80.8
Delta time to tail flick, test, before/after SA0.40.50.50.7-0.7
Tibia length4.111.511.53.4-3.4
Ambulatory time before self-admin0.61.81.8-1.31.4
Ambulatory time after self-admin3.86.16.1-2.52.5
Bone: tissue strength0.20.20.20.4-0.4
Total heroin consumption2.12.42.4-1.61.5
Bone: trabecular number0.30.50.60.7-0.7
Bone: trabecular spacing0.50.80.8-0.90.9
Bone: trabecular thickness0.30.40.40.6-0.6
Bone: trabecular tissue density0.71.21.2-1.11.1
Water consumed over 24 hours0.10.20.2-0.40.4
Number of responses in last shaping day0.40.60.6-0.70.7