Hub : Genes

LOC134482135

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression LOC134482135 0.26 0.11 3.5e-12 0.16 0.16 0.18 0.19 5.2e-09 5.0e-09 9.4e-10 2.5e-10
2 IC gene expression LOC134482135 0.41 0.13 6.1e-16 0.27 0.28 0.29 0.28 1.1e-11 2.3e-12 9.1e-13 5.1e-12
3 NAcc gene expression LOC134482135 0.11 0.05 0.0e+00 0.15 0.1 0.15 0.06 8.9e-22 2.6e-14 1.6e-21 2.8e-09
4 PL gene expression LOC134482135 0.36 0.12 0.0e+00 0.36 0.42 0.42 0.42 4.9e-41 5.9e-49 1.2e-49 4.7e-49
5 pVTA gene expression LOC134482135 0.15 0.06 3.9e-16 0.19 0.16 0.19 0.19 6.3e-15 9.2e-13 2.3e-15 3.4e-15
6 IL gene expression LOC134482135 0.29 0.16 1.9e-04 0.21 0.1 0.17 0.2 8.0e-06 1.8e-03 7.0e-05 1.2e-05
7 OFC gene expression LOC134482135 0.41 0.17 9.7e-06 0.13 0.13 0.06 0.12 5.4e-04 5.7e-04 1.2e-02 1.1e-03
8 Brain gene expression LOC134482135 0.16 0.08 1.2e-14 0.17 0.16 0.15 0.16 2.7e-15 7.4e-15 8.0e-14 8.2e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.52.72.9-1.71.61.61.71.71.71.71.6
Area under the delay curve0.20.40.50.5-0.6-0.4-0.7-0.6-0.6-0.6-0.7
BMI with tail0.10.50.90.9-0.8-0.9-0.7-0.7-0.5-0.5-0.4
BMI without tail0.10.41.50.7-0.6-1.2-0.5-0.3-0.5-0.50.2
Body weight0.20.81.60.8-0.8-0.4-0.9-1.0-1.0-1.0-1.2
Weight adjusted by age0.30.81.60.5-0.70.2-0.8-1.3-0.9-0.9-1.3
Bone surface1.02.02.8-1.51.51.71.41.31.41.41.0
Bone volume1.12.22.8-1.61.61.71.41.41.51.51.1
Breakpoint value in progressive ratio session0.00.00.0-0.2-0.10.10.00.00.10.10.0
Number of licking bursts0.00.10.20.00.2-0.40.10.30.30.30.5
Context. condit. distance diff. score0.50.62.00.1-0.1-1.40.30.60.40.41.4
Locomotion velocity, session 10.40.51.1-0.90.61.00.70.40.70.70.5
Locomotion distance, session 10.91.23.6-1.40.81.91.10.50.90.90.4
Locomotion velocity, session 20.30.41.5-0.80.51.20.60.30.50.50.0
Locomotion distance, session 21.42.05.6-1.71.22.41.40.81.21.20.5
Locomotion velocity, session 31.82.02.51.4-1.6-1.5-1.5-1.4-1.4-1.4-1.1
Locomotion distance, session 30.30.30.70.6-0.7-0.8-0.6-0.5-0.5-0.5-0.1
Stereotopy head waving bouts, day 30.10.10.20.2-0.5-0.1-0.3-0.5-0.3-0.3-0.5
Stereotopy head waving duration, day 31.41.72.31.2-1.4-0.9-1.3-1.5-1.3-1.3-1.5
Locomotion velocity, session 71.01.13.5-0.10.7-1.00.71.31.01.01.9
Locomotion distance, session 72.53.26.4-1.01.70.11.62.22.02.02.5
Stereotopy head waving bouts, day 71.01.21.90.7-1.2-0.4-1.0-1.3-1.2-1.2-1.4
Stereotopy head waving duration, day 72.53.14.31.5-1.9-1.1-1.7-2.1-1.9-1.9-1.9
Locomotion velocity, session 80.20.20.50.4-0.7-0.7-0.3-0.4-0.5-0.5-0.1
Locomotion distance, session 80.60.81.5-1.00.60.51.00.80.90.91.2
Degree of sensitization distance4.64.96.8-1.62.40.82.12.62.52.52.6
Degree of sensitization stereotypy1.41.62.01.0-1.3-0.8-1.2-1.4-1.4-1.4-1.4
Conditioned locomotion0.20.20.7-0.20.2-0.20.30.40.50.50.8
Cocaine response after cond. corrected0.30.51.80.9-0.8-1.4-0.6-0.3-0.4-0.40.3
Cocaine response after cond. not corrected0.10.20.70.5-0.5-0.8-0.2-0.1-0.1-0.10.4
Cocaine response before conditioning1.01.22.5-1.31.11.61.10.91.01.00.5
Saline control response0.30.41.2-0.70.71.10.50.40.40.4-0.1
Bone: connectivity density3.35.36.0-2.32.31.92.42.32.32.32.5
Bone: cortical apparent density0.50.72.21.2-0.5-1.5-0.9-0.5-0.7-0.7-0.3
Bone: cortical area0.10.10.50.1-0.10.3-0.3-0.3-0.3-0.3-0.7
Bone: cortical porosity0.40.51.00.3-0.70.1-0.6-0.8-0.7-0.7-1.0
Bone: cortical porosity0.50.61.40.4-0.70.2-0.6-0.9-0.8-0.8-1.2
Bone: cortical thickness0.30.40.80.6-0.5-0.4-0.7-0.6-0.7-0.7-0.9
Bone: cortical thickness0.30.40.80.7-0.6-0.9-0.7-0.4-0.6-0.6-0.3
Bone: cortical tissue density0.50.92.51.2-0.6-1.6-0.9-0.6-0.8-0.8-0.4
Condit. Reinf. active minus inactive responses0.10.10.3-0.1-0.00.4-0.1-0.2-0.3-0.3-0.5
Condit. Reinf. active-inactive response ratio0.40.40.60.6-0.8-0.5-0.6-0.7-0.6-0.6-0.5
Condit. Reinf. active responses0.40.51.5-0.90.81.20.70.50.40.40.0
Condit. Reinf. inactive responses2.33.05.0-2.02.02.21.71.61.51.50.9
Incentive salience index mean0.20.20.8-0.1-0.00.6-0.2-0.4-0.5-0.5-0.9
Condit. Reinf. lever presses0.20.31.2-0.50.41.10.2-0.1-0.2-0.2-0.7
Condit. Reinf. active minus inactive responses0.50.71.0-1.00.70.90.90.70.90.90.7
Condit. Reinf. active-inactive response ratio0.10.10.20.3-0.4-0.4-0.3-0.3-0.2-0.2-0.1
Condit. Reinf. active responses0.91.31.8-1.31.01.11.11.11.21.21.1
Condit. Reinf. inactive responses2.23.23.9-2.01.81.61.81.81.81.81.7
Condit. Reinf. lever presses0.10.10.6-0.40.40.80.20.10.10.1-0.3
Condit. Reinf. lever reinforcers received0.50.71.1-1.10.80.90.90.80.90.90.7
Conditioned reinforcement - actives0.20.71.1-0.70.70.20.81.00.90.91.0
Conditioned reinforcement - inactives0.71.82.5-1.31.41.11.61.51.31.31.3
Conditioned locomotion0.20.30.80.6-0.7-0.9-0.4-0.1-0.4-0.4-0.1
Patch foraging indifference point 0 sec1.64.610.9-2.42.33.32.01.81.91.90.9
Patch foraging indifference point AUC1.12.75.01.9-1.8-2.2-1.7-1.5-1.2-1.2-1.0
Delay disc. indifference point, 0s delay1.31.52.7-1.51.21.61.31.21.01.00.6
Delay disc. indifference point, 16s delay0.20.20.30.5-0.5-0.5-0.6-0.5-0.4-0.4-0.1
Delay disc. indifference point, 2s delay0.20.21.0-0.60.21.00.40.2-0.0-0.0-0.4
Delay disc. indifference point, 24s delay0.30.50.60.7-0.7-0.8-0.7-0.6-0.7-0.7-0.5
Delay disc. indifference point, 4s delay1.81.92.11.4-1.3-1.1-1.4-1.4-1.5-1.5-1.5
Delay disc. indifference point, 8s delay0.30.40.70.7-0.5-0.7-0.8-0.7-0.6-0.6-0.7
Indifference point function ln k0.30.92.2-1.21.11.51.00.80.50.50.4
Indifference point function log k0.30.92.2-1.21.11.51.00.80.50.50.4
Patch foraging total patch changes 0 sec1.13.39.2-2.02.03.01.71.41.51.50.6
Patch foraging total patch changes 12 sec0.20.30.9-0.50.51.00.40.40.60.6-0.0
Patch foraging total patch changes 18 sec0.00.10.2-0.30.40.40.30.30.30.30.2
Patch foraging total patch changes 24 sec0.10.21.4-0.40.21.20.2-0.10.20.2-0.4
Patch foraging total patch changes 6 sec0.10.20.3-0.30.50.60.30.40.40.40.1
Patch foraging time to switch 0 sec0.51.72.2-1.31.51.11.31.41.41.41.2
Patch foraging water rate 0 sec0.10.50.80.4-0.8-0.1-0.6-0.8-0.8-0.8-0.9
Patch foraging water rate 12 sec0.10.20.60.0-0.30.2-0.3-0.5-0.6-0.6-0.8
Patch foraging water rate 18 sec2.55.66.62.3-2.3-1.9-2.4-2.5-2.6-2.6-2.4
Patch foraging water rate 24 sec0.60.81.30.9-0.9-1.0-0.9-0.8-1.1-1.1-0.5
Patch foraging water rate 6 sec1.52.23.51.1-1.4-0.6-1.4-1.7-1.7-1.7-1.9
Seeking ratio, delayed vs. immediate footshock1.31.83.3-1.71.31.81.61.21.11.10.8
Distance traveled before self-admin0.40.91.40.7-0.9-0.2-0.9-1.0-1.1-1.1-1.2
Distance traveled after self-admin1.01.82.31.2-1.5-0.8-1.3-1.5-1.5-1.5-1.4
Extensor digitorum longus weight9.136.444.06.0-6.3-4.6-6.2-6.6-6.1-6.1-6.2
Bone: elastic displacement0.60.82.3-1.00.81.50.90.60.70.70.3
Bone: elastic work0.60.83.5-1.20.71.90.70.30.50.5-0.2
Bone: endosteal estimation0.10.30.7-0.50.60.80.30.40.50.50.1
Bone: endosteal perimeter0.51.22.8-1.21.01.71.00.81.01.00.4
Epididymis fat weight0.20.81.2-0.81.10.70.80.90.90.90.9
Delta time in closed arm before/after self-admin1.71.62.1-1.41.11.01.41.31.21.21.5
Delta time in open arm before/after self-admin0.10.10.20.3-0.3-0.3-0.4-0.4-0.2-0.2-0.5
Diff in mean of infusions in LGA sessions0.00.10.3-0.10.00.3-0.1-0.3-0.3-0.3-0.5
Delay discount exponential model param0.81.11.3-1.01.00.81.11.11.11.11.1
Extinction: sum of active levers before priming0.40.70.8-0.90.90.80.90.80.70.70.8
Active lever presses in extinction session 60.10.10.70.4-0.2-0.8-0.30.1-0.1-0.10.2
Bone: final force0.10.10.40.2-0.10.2-0.4-0.2-0.2-0.2-0.6
Bone: final moment0.10.10.5-0.00.10.4-0.3-0.2-0.2-0.2-0.7
Food consumed during 24 hour testing period0.30.51.20.4-0.4-0.2-0.6-0.7-0.9-0.9-1.1
Glucose1.11.82.91.6-1.3-1.7-1.4-1.2-1.3-1.3-0.9
Heart weight0.60.91.2-1.01.10.60.91.01.01.00.9
Delay discount hyperbolic model param0.70.91.2-0.80.90.61.01.01.01.01.1
Intermittent access intake day 1-15 change0.10.60.9-0.70.70.70.90.80.80.80.9
Intermittent access intake escalation0.10.40.7-0.50.60.60.70.70.70.70.8
Intermittent access intake escalation 20.00.10.1-0.10.20.20.20.20.20.20.4
Intermitt. access day 1 inactive lever presses0.11.11.7-0.71.10.51.11.31.21.21.2
Intermitt. access day 15 inactive lever presses0.10.71.21.0-0.8-1.1-0.8-0.8-0.8-0.8-0.6
Intermitt. access escalation Index0.20.71.0-1.00.80.90.90.80.80.80.7
Intermittent access day 1 total infusions0.10.30.50.5-0.7-0.6-0.5-0.4-0.6-0.6-0.6
Intermittent access day 15 total infusions0.10.10.3-0.20.2-0.00.40.50.40.40.6
Intermittent access terminal intake (last 3 days)0.20.31.00.7-0.6-1.0-0.5-0.3-0.4-0.4-0.2
Intermittent access total infusions0.10.10.4-0.10.1-0.40.30.60.30.30.6
Intermittent access day 1 locomotion0.10.20.4-0.60.40.50.50.60.40.40.2
Intermittent access day 15 total locomotion0.20.71.31.1-0.8-1.1-0.8-0.5-0.9-0.9-0.5
Intermittent access total locomotion0.00.00.10.1-0.1-0.3-0.00.2-0.1-0.1-0.0
Intermittent access standard deviation0.62.93.21.7-1.8-1.6-1.7-1.6-1.8-1.8-1.6
Left kidney weight0.10.41.30.4-0.2-0.1-0.6-0.6-0.7-0.7-1.2
Right kidney weight0.00.31.0-0.60.61.00.30.10.10.1-0.7
Cocaine induced anxiety0.10.41.3-0.80.61.10.40.10.40.4-0.3
Post-drug Anxiety3.54.06.3-2.32.12.51.91.52.02.01.2
Baseline Anxiety0.71.11.6-1.01.00.81.01.01.21.21.3
Tail length0.20.91.4-1.11.11.20.90.90.80.80.5
Length with tail0.10.72.2-1.01.01.50.70.40.50.5-0.2
Length without tail0.31.64.31.0-0.90.1-1.2-1.5-1.2-1.2-2.1
Times rat made contact with spout0.00.00.10.2-0.1-0.4-0.1-0.0-0.2-0.20.0
Lifetime Intake0.10.10.30.1-0.1-0.60.00.30.00.00.3
Liver weight, left1.01.73.70.9-1.0-0.1-1.2-1.5-1.5-1.5-1.9
Liver weight, right2.54.45.02.2-2.1-1.9-2.2-2.2-2.1-2.1-1.9
Locomotor activity0.40.62.2-0.40.11.2-0.1-0.6-0.4-0.4-1.5
Locomotor testing distance2.15.211.2-2.82.43.32.31.81.91.90.8
Locomotor testing rearing1.96.915.7-3.22.74.02.62.12.32.30.8
Locomotion in novel chamber0.10.10.2-0.30.30.20.30.40.20.20.5
Locomotion in novel chamber post-restriction0.31.02.00.9-1.4-0.6-1.0-1.1-0.9-0.9-0.8
Fecal boli incidents, locomotor time 11.12.83.91.8-1.2-1.6-2.0-1.6-1.6-1.6-1.9
Change in fecal boli incidents, locomotor task0.20.30.6-0.30.40.30.60.50.50.50.8
Time >=10cm from walls, locomotor time 10.91.11.6-1.11.31.31.10.91.01.00.7
Bouts of movement, locomotor time 10.60.81.50.8-1.2-0.9-0.9-0.9-0.8-0.8-0.7
Total resting periods, locomotor time 11.11.22.31.1-1.5-1.3-1.1-1.0-1.0-1.0-0.6
Rest time, locomotor task time 10.50.82.01.0-1.4-1.1-0.9-0.8-0.7-0.7-0.2
Distance moved, locomotor task time 10.51.32.2-1.11.51.21.11.01.21.20.8
Vertical activity count, locomotor time 10.00.21.1-0.40.41.10.2-0.1-0.0-0.0-0.5
Time >=10cm from walls, locomotor time 20.00.10.20.5-0.2-0.3-0.4-0.4-0.4-0.4-0.4
Bouts of movement, locomotor time 20.61.92.61.3-1.6-1.6-1.3-1.3-1.4-1.4-1.0
Total resting periods, locomotor time 20.83.34.71.8-2.1-2.2-1.8-1.7-1.8-1.8-1.3
Rest time, locomotor task time 24.88.210.53.1-3.2-3.2-2.9-2.7-2.7-2.7-2.0
Distance moved, locomotor task time 22.53.35.0-2.02.12.21.81.71.61.61.2
Vertical activity count, locomotor time 20.30.72.5-1.10.91.60.80.50.40.4-0.0
Light reinforcement 10.10.71.0-0.71.00.40.80.90.80.80.9
Light reinforcement 20.20.42.10.6-0.3-1.5-0.4-0.1-0.3-0.30.4
Bone: marrow area0.10.30.8-0.60.70.90.40.50.60.60.2
Bone: maximum diameter0.40.71.00.7-0.9-0.4-0.9-1.0-0.8-0.8-1.0
Bone: maximum force0.20.41.40.4-0.40.2-0.8-0.7-0.6-0.6-1.2
Bone: maximum moment0.20.41.50.2-0.10.5-0.6-0.6-0.5-0.5-1.2
Mean time between licks in bursts1.05.76.5-2.52.42.22.52.42.42.42.4
Mean num. licks in bursts0.00.10.20.2-0.30.0-0.3-0.3-0.4-0.4-0.4
Cd content in liver0.80.92.40.6-0.8-0.2-0.9-1.2-1.0-1.0-1.5
Co content in liver3.23.84.42.1-2.1-1.9-2.1-2.0-1.8-1.8-1.7
Cu content in liver1.01.21.41.1-1.2-1.2-1.1-1.1-1.1-1.1-1.0
Fe content in liver2.22.73.0-1.61.71.31.71.71.71.71.5
K content in liver0.90.91.9-0.90.80.31.01.10.90.91.4
Mg content in liver1.21.32.0-1.21.00.81.31.21.11.11.4
Mn content in liver2.12.42.5-1.61.51.41.61.51.61.61.6
Na content in liver1.31.43.00.7-1.10.1-1.0-1.4-1.4-1.4-1.7
Rb content in liver0.00.10.2-0.10.3-0.10.30.30.20.20.4
Se content in liver3.33.86.4-2.51.92.52.21.71.71.71.1
Sr content in liver0.70.61.0-1.00.60.90.90.60.80.80.7
Zn content in liver0.60.71.2-1.10.71.11.00.80.70.70.5
Bone: minimum diameter0.10.21.00.1-0.10.5-0.4-0.4-0.3-0.3-1.0
Time in familiar zone, hab. session 10.20.20.3-0.50.50.20.50.50.40.40.5
Time in novel zone, hab. session 12.52.83.51.9-1.8-1.6-1.8-1.7-1.6-1.6-1.4
Total zone transitions, hab. session 10.10.10.3-0.10.00.5-0.0-0.2-0.1-0.1-0.5
Total locomotion distance, hab. session 10.50.71.8-1.10.91.30.90.60.70.70.2
Locomotion velocity, hab. session 11.52.14.6-1.81.52.11.51.11.21.20.6
Time in familiar zone, hab. session 20.10.10.60.5-0.3-0.8-0.3-0.0-0.0-0.00.3
Time in novel zone, hab. session 20.10.10.3-0.40.10.60.20.0-0.1-0.1-0.2
Total zone transitions, hab. session 20.30.30.80.0-0.50.5-0.3-0.7-0.6-0.6-0.9
Total locomotion distance, hab. session 20.10.10.6-0.60.10.70.30.00.00.0-0.2
Locomotion velocity, hab. session 20.10.10.5-0.4-0.10.70.1-0.2-0.2-0.2-0.5
Novel to familiar place preference ratio0.20.30.5-0.50.70.70.40.50.40.40.1
Novelty place preference0.30.40.8-0.70.80.90.60.60.60.60.2
Time in novel zone, NPP test0.30.30.8-0.60.70.90.50.50.50.50.1
Total zone transitions, NPP test1.11.63.2-1.61.11.81.30.91.11.10.8
Total locomotion distance, NPP test5.57.69.7-3.12.83.02.92.62.62.62.2
Locomotion velocity, NPP test4.46.37.6-2.82.62.72.72.42.42.42.0
Intraocular pressure1.42.32.6-1.61.51.61.61.41.51.51.5
Delta distance traveled before/after self-admin0.70.71.01.0-0.9-0.8-0.9-0.9-0.8-0.8-0.7
Delta ambulatory time before/after self-admin0.50.91.31.1-1.0-0.8-1.0-1.0-0.9-0.9-0.8
Parametrial fat weight2.66.27.4-2.42.52.12.42.52.72.72.5
Pavlov. Cond. lever latency0.10.20.6-0.10.0-0.20.30.30.50.50.8
Pavlov. Cond. magazine entry latency0.00.00.10.10.00.0-0.1-0.1-0.3-0.3-0.3
Pavlov. Cond. change in total contacts1.51.63.40.9-1.0-0.2-1.2-1.4-1.4-1.4-1.8
Pavlov. Cond. index score0.40.51.20.5-0.5-0.1-0.7-0.7-0.9-0.9-1.1
Pavlov. Cond. latency score0.20.30.80.2-0.20.0-0.5-0.5-0.7-0.7-0.9
Pavlov. Cond. lever contacts0.10.20.50.1-0.00.2-0.3-0.3-0.6-0.6-0.7
Pavlov. Cond. magazine entry number0.81.11.5-0.90.90.61.01.11.21.21.2
Pavlov. Cond. intertrial magazine entries0.70.81.8-1.01.01.40.90.80.80.80.4
Pavlov. Cond. lever-magazine prob. diff.0.60.81.50.6-0.7-0.3-0.8-0.9-1.1-1.1-1.2
Pavlov. Cond. response bias0.81.01.40.9-0.8-0.6-1.0-1.0-1.2-1.2-1.2
Pavlov. Cond. lever latency0.81.12.4-0.70.80.11.01.21.11.11.5
Pavlov. Cond. magazine entry latency0.10.20.60.2-0.10.2-0.4-0.4-0.5-0.5-0.8
Pavlov. Cond. change in total contacts1.33.14.81.5-1.6-0.8-1.8-2.0-1.9-1.9-2.2
Pavlov. Cond. index score0.71.12.30.7-0.8-0.1-1.0-1.2-1.2-1.2-1.5
Pavlov. Cond. latency score0.40.71.70.5-0.60.1-0.7-1.0-0.9-0.9-1.3
Pavlov. Cond. lever contacts0.71.12.50.7-0.8-0.1-1.0-1.2-1.2-1.2-1.6
Pavlov. Cond. magazine entry number0.00.10.20.1-0.1-0.50.00.10.10.10.4
Pavlov. Cond. intertrial magazine entries5.111.212.6-3.53.42.73.43.53.53.53.3
Pavlov. Cond. lever-magazine prob. diff.0.81.32.50.9-1.0-0.3-1.1-1.3-1.3-1.3-1.6
Pavlov. Cond. response bias0.81.12.50.7-0.8-0.0-1.0-1.2-1.2-1.2-1.6
Time in closed arm before self-admin0.20.30.40.7-0.5-0.6-0.6-0.6-0.6-0.6-0.7
Time in closed arm after self-admin0.50.60.8-0.80.80.60.90.80.60.60.8
Time in open arm before self-admin0.70.81.1-1.00.81.11.00.90.80.81.0
Time in open arm after self-admin0.00.00.1-0.30.10.10.20.10.20.20.3
Bone: periosteal estimation0.00.10.4-0.20.30.6-0.00.10.20.2-0.3
Bone: periosteal perimeter0.20.41.4-0.80.61.20.50.40.60.60.1
Bone: post-yield work0.71.22.91.4-1.0-1.7-1.3-0.7-0.9-0.9-0.5
Progressive ratio test 1 active lever presses0.50.92.01.0-1.0-1.4-0.9-0.6-0.9-0.9-0.5
Progressive ratio test 1 breakpoint0.61.02.11.1-1.1-1.4-1.0-0.7-1.0-1.0-0.7
Progressive ratio test 1 inactive lever presses0.41.01.5-0.91.10.41.11.21.01.01.2
Progressive ratio test 2 active lever presses0.81.21.71.2-1.0-1.3-1.0-0.8-1.2-1.2-0.8
Progressive ratio test 2 breakpoint0.91.21.51.2-1.0-1.2-1.0-0.8-1.2-1.2-0.9
Progressive ratio test 2 inactive lever presses0.00.10.60.4-0.1-0.8-0.10.1-0.2-0.20.2
Incentive Sensitization - Responses0.30.71.20.7-0.7-0.4-0.7-0.8-1.1-1.1-1.0
Incentive Sensitization - Breakpoint0.30.61.00.6-0.6-0.3-0.6-0.7-1.0-1.0-0.9
Sum of active levers in priming session hrs 5-60.30.30.9-0.20.5-0.30.40.70.50.50.9
Progressive ratio0.51.31.91.0-1.3-0.6-0.9-1.3-1.4-1.4-1.2
Food seeking constrained by brief footshock1.01.33.11.1-1.6-1.8-0.8-0.8-1.0-1.00.1
Seeking ratio, punishment vs. effort0.10.10.60.2-0.4-0.8-0.10.10.10.10.6
Retroperitoneal fat weight0.52.42.9-1.51.71.11.61.71.61.61.6
Reaction time number correct0.00.00.10.10.1-0.3-0.00.10.10.10.1
Reaction time mean minus median0.00.00.2-0.20.00.40.1-0.10.10.1-0.1
Reaction time mean minus median AUC0.00.00.0-0.10.10.20.1-0.10.00.0-0.0
Reaction time num false alarms0.10.30.8-0.50.50.90.40.30.50.50.1
Reaction time num false alarms AUC0.00.00.20.00.00.4-0.1-0.2-0.1-0.1-0.4
Reaction time trials correct on left0.00.00.10.10.1-0.3-0.00.10.10.10.1
Reaction time trials on left0.00.00.1-0.00.1-0.20.10.20.20.20.2
Reaction time mean0.10.10.30.2-0.4-0.4-0.3-0.5-0.4-0.4-0.3
Reaction time mean AUC0.10.20.40.3-0.4-0.3-0.3-0.6-0.4-0.4-0.4
Median of all reaction times0.20.30.40.5-0.5-0.7-0.5-0.6-0.6-0.6-0.4
Reaction time omissions1.52.42.8-1.61.51.21.71.51.61.61.7
Reaction time false alarm rate0.00.00.1-0.10.10.4-0.0-0.10.00.0-0.2
Reaction time premature initiation rate0.60.91.50.8-1.2-0.8-0.9-1.1-1.0-1.0-0.8
Reaction time premature initiations0.30.91.30.9-1.2-1.0-0.9-1.1-0.9-0.9-0.7
Std. dev. reaction times0.00.00.10.0-0.2-0.1-0.1-0.3-0.1-0.1-0.1
Reaction time trials completed0.00.00.1-0.00.1-0.20.10.20.20.20.2
Reaction time trials AUC0.00.00.00.00.2-0.20.00.20.20.20.2
Run reversals in cocaine runway, females0.40.40.9-0.80.30.40.70.70.60.60.9
Run reversals in cocaine runway, males7.38.09.82.8-2.9-2.1-3.0-3.1-2.8-2.8-3.0
Latency to leave start box in cocaine runway0.81.01.50.9-1.2-0.7-0.9-1.0-1.2-1.2-1.0
Latency to leave start box in cocaine runway, F2.53.23.71.8-1.8-1.4-1.7-1.8-1.9-1.9-1.8
Latency to leave start box in cocaine runway, M0.20.20.6-0.80.10.50.60.30.20.20.4
Std. dev. time between licks in bursts4.68.712.7-3.33.03.63.12.72.82.82.3
Total sessions with >9 infusions0.00.00.20.1-0.2-0.4-0.00.1-0.1-0.10.1
Short access day 1 total inactive lever presses1.52.93.71.7-1.9-1.8-1.8-1.6-1.7-1.7-1.5
Short access day 10 total inactive lever presses0.00.10.1-0.20.30.30.30.30.40.40.3
Short access day 1 total infusions0.20.51.40.8-0.8-1.2-0.6-0.4-0.6-0.6-0.3
Short access day 10 total infusions0.61.01.60.8-1.0-0.6-0.9-1.0-1.1-1.1-1.2
Short access total infusions0.40.60.80.7-0.9-0.8-0.7-0.7-0.8-0.8-0.8
Short access day 1 locomotion0.50.81.50.7-0.8-0.5-0.9-0.8-1.1-1.1-1.2
Short access day 10 total locomotion0.00.10.1-0.30.20.20.30.30.10.10.0
Short access total locomotion0.10.20.40.1-0.4-0.1-0.3-0.3-0.5-0.5-0.7
One hour access (0.3 mA shock)0.00.00.1-0.0-0.1-0.10.10.4-0.1-0.10.1
Compulsive drug intake1.72.53.0-1.71.51.51.71.71.51.51.4
One hour access (shock baseline)0.10.30.50.6-0.7-0.7-0.5-0.4-0.5-0.5-0.3
Social response proportion0.10.20.7-0.1-0.0-0.60.30.40.30.30.8
Social responses4.55.96.9-2.52.42.02.62.52.42.42.6
Social time0.50.81.5-1.01.11.20.90.80.90.90.3
Soleus weight0.72.02.51.6-1.6-1.4-1.5-1.5-1.2-1.2-1.2
Bone: stiffness0.40.81.20.9-0.8-0.6-1.0-1.0-0.8-0.8-1.1
Tibialis anterior weight6.221.326.54.5-4.7-3.3-4.8-5.1-4.6-4.6-5.0
Time to tail flick, vehicle, before self-admin0.20.20.3-0.40.60.30.30.50.50.50.3
Time to tail flick, vehicle, after self-admin1.12.23.11.7-1.8-1.7-1.5-1.5-1.3-1.3-1.0
Time to tail flick, test, before self-admin2.32.63.1-1.81.61.51.61.51.61.61.6
Time to tail flick, test, after self-admin3.63.86.7-1.71.90.81.92.22.02.02.6
Delta time to tail flick, vehicle, before/after SA0.91.02.11.2-1.1-1.5-1.0-0.9-0.8-0.8-0.3
Delta time to tail flick, test, before/after SA0.20.31.10.20.2-0.70.30.60.40.41.1
Tibia length1.23.37.7-2.22.12.81.71.51.41.40.4
Ambulatory time before self-admin0.20.61.20.6-0.7-0.3-0.8-0.8-0.9-0.9-1.1
Ambulatory time after self-admin2.33.74.51.8-2.0-1.2-2.0-2.1-2.0-2.0-2.1
Bone: tissue strength0.10.10.2-0.30.40.40.20.20.40.40.0
Total heroin consumption3.13.65.01.9-1.7-1.6-1.9-1.8-2.0-2.0-2.2
Bone: trabecular number2.03.84.2-2.01.91.82.02.01.91.92.0
Bone: trabecular spacing1.92.83.31.7-1.8-1.4-1.7-1.8-1.7-1.7-1.7
Bone: trabecular thickness0.30.40.7-0.70.80.90.60.70.60.60.3
Bone: trabecular tissue density0.91.62.21.3-1.1-1.0-1.4-1.3-1.2-1.2-1.5
Water consumed over 24 hours0.71.41.80.9-1.2-0.7-1.1-1.3-1.3-1.3-1.3
Number of responses in last shaping day1.41.82.31.2-1.3-1.0-1.4-1.5-1.4-1.4-1.4