LOC134481727

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	LOC134481727	0.08	0.05	1.9e-09	0.1	0.09	0.09	0.1	5.4e-11	8.8e-10	9.9e-10	2.2e-11
2	BLA	gene expression	LOC134481727	0.08	0.05	1.1e-03	0.02	0.02	0.02	0.02	2.2e-02	4.4e-02	2.1e-02	4.2e-02
3	Brain	gene expression	LOC134481727	0.07	0.04	5.5e-07	0.06	0.07	0.07	0.06	5.8e-06	2.9e-07	6.6e-07	1.0e-06
4	Liver	gene expression	LOC134481727	0.07	0.04	1.7e-06	0.05	0.05	0.03	0.05	4.4e-06	5.8e-06	1.8e-04	3.0e-06
5	NAcc	gene expression	LOC134481727	0.03	0.02	7.4e-04	0.03	0.02	0.03	0.03	5.2e-05	3.2e-04	9.8e-05	4.1e-05
6	pVTA	gene expression	LOC134481727	0.33	0.1	0.0e+00	0.33	0.34	0.34	0.24	6.2e-27	2.6e-28	1.5e-28	1.5e-19

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.4	0.7	3.4	1.9	0.5	0.4	-0.0	-0.2	-0.4
Area under the delay curve	0.9	1.4	2.2	0.4	1.5	-1.4	1.4	-0.8	1.3
BMI with tail	1.4	4.9	22.5	4.7	2.2	-0.4	0.6	-1.3	0.3
BMI without tail	0.2	1.0	4.8	2.2	0.4	0.4	-0.6	0.1	-0.5
Body weight	0.2	0.9	1.7	0.1	-1.1	1.3	-1.3	0.5	-0.6
Weight adjusted by age	0.2	0.6	1.7	0.1	0.1	0.8	-0.6	1.3	-1.0
Bone surface	0.8	1.5	2.4	1.0	-0.8	1.6	-1.2	1.2	-1.4
Bone volume	0.2	0.5	1.4	1.2	0.0	0.8	-0.5	0.4	-0.7
Breakpoint value in progressive ratio session	0.1	0.1	0.2	-0.1	0.0	0.5	-0.4	0.3	-0.4
Number of licking bursts	0.0	0.1	0.5	-0.7	-0.0	0.1	-0.2	0.1	0.1
Context. condit. distance diff. score	3.0	3.6	5.0	1.8	2.2	-1.8	2.0	-1.9	1.7
Locomotion velocity, session 1	0.8	0.9	1.4	1.1	1.2	-0.8	0.8	-0.9	0.8
Locomotion distance, session 1	2.5	3.2	5.7	1.9	2.4	-1.5	1.6	-1.7	1.5
Locomotion velocity, session 2	0.2	0.2	0.5	0.7	0.4	-0.3	0.4	-0.4	0.4
Locomotion distance, session 2	1.4	2.0	2.5	1.1	1.6	-1.6	1.3	-1.4	1.5
Locomotion velocity, session 3	1.5	1.7	2.9	0.8	1.7	-1.2	1.4	-1.3	1.3
Locomotion distance, session 3	2.2	2.5	4.7	2.2	2.0	-1.3	1.4	-1.2	1.0
Stereotopy head waving bouts, day 3	0.5	0.5	0.8	-0.2	0.9	-0.9	0.8	-0.6	0.8
Stereotopy head waving duration, day 3	0.6	0.8	1.0	-0.2	0.8	-1.0	1.0	-0.9	0.9
Locomotion velocity, session 7	1.1	1.2	1.7	0.6	0.9	-1.2	1.3	-1.2	1.2
Locomotion distance, session 7	0.4	0.5	0.7	0.6	0.6	-0.8	0.9	-0.8	0.7
Stereotopy head waving bouts, day 7	0.1	0.2	0.5	0.6	0.7	0.1	-0.1	0.3	-0.3
Stereotopy head waving duration, day 7	0.1	0.1	0.4	0.1	0.7	-0.1	0.1	0.0	-0.0
Locomotion velocity, session 8	4.8	5.8	9.2	3.0	2.7	-2.0	2.2	-2.4	1.8
Locomotion distance, session 8	3.9	5.7	8.3	2.6	2.9	-2.2	2.3	-2.3	2.0
Degree of sensitization distance	0.9	1.0	2.5	-1.5	-1.6	0.6	-0.7	0.5	-0.5
Degree of sensitization stereotypy	0.0	0.0	0.1	0.1	0.4	0.2	-0.2	0.2	-0.2
Conditioned locomotion	0.1	0.1	0.5	-0.7	-0.1	-0.2	0.2	-0.5	-0.0
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.4	-0.1	0.2	-0.2	0.4	-0.3
Cocaine response after cond. not corrected	0.3	0.5	0.8	0.3	-0.4	0.8	-0.6	0.8	-0.9
Cocaine response before conditioning	1.0	1.3	1.9	1.4	-0.7	1.3	-0.9	1.0	-1.3
Saline control response	0.0	0.1	0.1	0.4	0.3	0.0	0.1	0.1	-0.4
Bone: connectivity density	0.5	0.8	4.0	2.0	0.6	0.2	0.3	-0.3	-0.2
Bone: cortical apparent density	0.3	0.5	0.7	0.6	0.8	-0.8	0.8	-0.7	0.7
Bone: cortical area	0.4	0.7	2.1	1.5	0.5	0.9	-0.5	0.5	-0.8
Bone: cortical porosity	0.1	0.1	0.2	-0.1	0.3	-0.4	0.4	-0.4	0.3
Bone: cortical porosity	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2	0.1	-0.2
Bone: cortical thickness	1.0	1.7	7.9	2.8	1.2	0.4	-0.1	0.2	-0.8
Bone: cortical thickness	0.7	0.9	1.6	0.4	-0.7	1.1	-1.0	1.0	-1.3
Bone: cortical tissue density	0.3	0.5	0.7	0.5	0.7	-0.8	0.8	-0.6	0.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.9	-0.9	-0.5	0.2	-0.3	0.5	-0.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.1	-1.0	-0.6	0.2	-0.4	0.6	-0.2
Condit. Reinf. active responses	0.0	0.0	0.2	-0.4	0.0	-0.2	0.1	0.1	0.2
Condit. Reinf. inactive responses	0.0	0.1	0.2	0.5	0.2	-0.0	0.1	-0.2	0.1
Incentive salience index mean	0.1	0.1	0.1	-0.3	0.2	-0.3	0.3	-0.2	0.4
Condit. Reinf. lever presses	0.0	0.0	0.2	0.4	0.3	-0.0	0.1	-0.1	-0.1
Condit. Reinf. active minus inactive responses	0.1	0.2	0.8	0.9	0.5	-0.1	0.1	-0.1	0.2
Condit. Reinf. active-inactive response ratio	1.3	2.0	2.7	-0.5	-1.6	1.5	-1.5	1.6	-1.4
Condit. Reinf. active responses	0.5	0.6	1.0	0.6	1.0	-0.8	0.7	-0.7	0.9
Condit. Reinf. inactive responses	1.1	1.6	2.5	0.6	1.6	-1.3	1.2	-1.2	1.4
Condit. Reinf. lever presses	0.2	0.3	0.7	-0.9	-0.1	-0.3	0.4	-0.4	0.7
Condit. Reinf. lever reinforcers received	0.6	0.8	1.2	0.7	1.1	-0.9	0.8	-0.8	1.0
Conditioned reinforcement - actives	0.1	0.2	0.4	-0.1	0.4	-0.7	0.5	-0.5	0.6
Conditioned reinforcement - inactives	0.1	0.3	0.7	-0.4	-0.4	0.6	-0.8	0.1	-0.3
Conditioned locomotion	0.7	1.0	3.7	-1.9	0.0	-0.6	0.4	-0.9	1.1
Patch foraging indifference point 0 sec	0.3	0.8	1.4	0.3	0.8	-0.8	0.8	-1.2	1.0
Patch foraging indifference point AUC	0.1	0.2	0.3	-0.2	0.3	-0.2	0.5	-0.5	0.5
Delay disc. indifference point, 0s delay	0.3	0.3	0.6	0.3	0.8	-0.7	0.6	-0.4	0.7
Delay disc. indifference point, 16s delay	0.6	0.8	1.1	0.9	1.0	-1.1	0.9	-0.6	0.9
Delay disc. indifference point, 2s delay	0.8	0.9	1.2	-0.5	0.8	-1.1	1.1	-0.9	1.0
Delay disc. indifference point, 24s delay	0.9	1.4	2.2	-1.0	1.1	-1.3	1.3	-0.9	1.5
Delay disc. indifference point, 4s delay	3.1	3.3	4.8	0.7	2.2	-2.1	2.0	-1.6	1.9
Delay disc. indifference point, 8s delay	0.2	0.4	1.0	0.7	1.0	-0.6	0.6	0.1	0.3
Indifference point function ln k	0.1	0.2	0.4	0.5	-0.5	0.4	-0.6	0.5	-0.4
Indifference point function log k	0.1	0.2	0.4	0.5	-0.5	0.4	-0.6	0.5	-0.4
Patch foraging total patch changes 0 sec	0.3	0.8	1.4	0.2	0.8	-0.9	0.9	-1.2	1.1
Patch foraging total patch changes 12 sec	1.5	2.0	2.6	0.6	1.6	-1.5	1.6	-1.4	1.4
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	-0.2	0.0	0.3	-0.1	-0.0	0.0
Patch foraging total patch changes 24 sec	1.0	3.5	5.7	0.2	1.8	-1.9	1.8	-2.4	2.2
Patch foraging total patch changes 6 sec	1.5	2.6	3.9	0.3	1.6	-1.7	1.7	-2.0	1.8
Patch foraging time to switch 0 sec	0.1	0.4	0.9	0.2	-0.3	0.7	-0.5	1.0	-0.9
Patch foraging water rate 0 sec	0.1	0.3	0.5	-0.7	-0.5	-0.3	0.2	-0.7	0.5
Patch foraging water rate 12 sec	0.2	1.0	1.9	0.1	0.7	-1.1	1.0	-1.4	1.1
Patch foraging water rate 18 sec	0.2	0.5	1.1	-0.0	0.2	-0.6	0.5	-1.0	1.0
Patch foraging water rate 24 sec	0.4	0.6	1.7	-1.3	-1.1	0.4	-0.6	0.2	-0.2
Patch foraging water rate 6 sec	0.8	1.2	1.9	-0.7	0.5	-1.2	1.1	-1.4	1.4
Seeking ratio, delayed vs. immediate footshock	0.5	0.7	1.2	-0.2	0.5	-1.1	0.6	-1.1	1.0
Distance traveled before self-admin	0.1	0.3	0.7	-0.8	0.3	-0.6	0.5	-0.2	0.5
Distance traveled after self-admin	1.1	2.0	2.8	-1.4	1.1	-1.6	1.2	-1.2	1.7
Extensor digitorum longus weight	2.1	8.6	35.2	5.9	0.9	2.0	-1.3	1.4	-2.7
Bone: elastic displacement	0.5	0.7	1.8	1.3	-0.0	0.9	-0.7	0.5	-0.9
Bone: elastic work	1.1	1.4	3.1	1.8	-0.1	1.3	-1.1	0.9	-1.3
Bone: endosteal estimation	0.5	1.2	3.1	-1.8	-1.3	0.8	-0.9	0.8	-0.4
Bone: endosteal perimeter	0.5	1.3	1.8	-1.1	-1.0	1.3	-1.1	1.3	-0.9
Epididymis fat weight	0.1	0.6	1.3	-0.4	0.4	-1.1	0.8	-0.6	1.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	0.3	0.2	-0.3	0.5	-0.2	0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.1	-0.4	-0.3	-0.3	0.3	0.1	0.0
Diff in mean of infusions in LGA sessions	1.2	2.2	2.8	-0.8	-1.5	1.7	-1.6	1.6	-1.6
Delay discount exponential model param	1.2	1.6	2.4	-0.3	-1.6	1.5	-1.5	0.9	-1.4
Extinction: sum of active levers before priming	0.5	0.8	1.7	-1.0	-0.7	-0.5	0.4	-1.3	0.9
Active lever presses in extinction session 6	0.6	0.6	2.5	-1.6	-0.8	0.1	-0.3	-0.1	0.3
Bone: final force	0.3	0.5	0.7	-0.0	-0.7	0.8	-0.8	0.8	-0.8
Bone: final moment	0.3	0.5	0.6	-0.3	-0.7	0.7	-0.7	0.8	-0.7
Food consumed during 24 hour testing period	0.1	0.3	0.9	0.8	1.0	-0.0	0.2	-0.1	0.1
Glucose	0.3	0.5	1.6	-1.3	-0.0	-0.8	0.5	-0.4	0.9
Heart weight	0.6	0.9	1.5	0.7	-1.0	1.1	-1.2	0.8	-0.9
Delay discount hyperbolic model param	1.5	1.9	2.9	-0.3	-1.7	1.6	-1.6	1.0	-1.5
Intermittent access intake day 1-15 change	0.0	0.1	0.3	-0.4	-0.6	-0.2	-0.5	-0.1	0.2
Intermittent access intake escalation	0.0	0.1	0.3	-0.1	-0.5	-0.1	-0.6	-0.1	0.1
Intermittent access intake escalation 2	0.3	0.5	0.9	-0.9	-0.3	-0.7	0.1	-0.9	0.9
Intermitt. access day 1 inactive lever presses	0.2	2.4	4.0	2.0	2.0	-1.0	1.1	-1.6	1.3
Intermitt. access day 15 inactive lever presses	0.2	0.9	1.5	-0.4	-1.1	1.2	-1.2	0.7	-0.9
Intermitt. access escalation Index	0.6	2.0	3.7	-0.9	-1.9	1.3	-1.5	1.3	-1.4
Intermittent access day 1 total infusions	0.0	0.1	0.5	-0.7	-0.4	0.2	-0.0	-0.2	0.1
Intermittent access day 15 total infusions	0.1	0.3	0.6	-0.8	-0.2	-0.6	0.2	-0.8	0.7
Intermittent access terminal intake (last 3 days)	0.5	0.9	1.7	-1.3	-0.4	-0.8	0.4	-1.2	1.1
Intermittent access total infusions	0.2	0.3	0.6	-0.8	-0.5	-0.3	0.0	-0.7	0.5
Intermittent access day 1 locomotion	0.1	0.1	0.5	-0.7	0.1	0.3	-0.2	-0.1	0.0
Intermittent access day 15 total locomotion	0.7	2.7	4.3	-0.5	1.7	-1.8	1.6	-1.6	2.1
Intermittent access total locomotion	0.3	0.4	1.7	-1.3	-0.4	-0.3	-0.0	-0.4	0.5
Intermittent access standard deviation	0.1	0.5	1.1	0.3	0.4	-0.9	0.5	-1.0	1.0
Left kidney weight	0.2	1.4	2.3	0.1	-1.4	1.5	-1.5	0.8	-1.0
Right kidney weight	0.5	3.6	7.0	-1.5	-2.7	2.1	-2.0	1.5	-1.3
Cocaine induced anxiety	2.0	5.4	6.5	-1.3	-2.4	2.4	-2.6	2.5	-2.5
Post-drug Anxiety	2.3	2.6	4.2	-0.3	-1.5	1.6	-1.7	2.0	-2.0
Baseline Anxiety	1.6	2.6	3.8	1.2	1.9	-1.9	1.9	-1.2	1.5
Tail length	0.9	5.1	21.4	-4.6	-2.6	0.5	-1.1	0.9	-0.0
Length with tail	2.4	10.7	33.0	-5.7	-4.2	1.8	-2.2	2.0	-1.0
Length without tail	0.4	1.9	3.7	-1.9	-1.9	1.2	-1.2	1.0	-0.6
Times rat made contact with spout	0.1	0.1	0.2	0.1	-0.5	0.2	-0.1	0.1	-0.5
Lifetime Intake	0.2	0.2	0.6	-0.8	-0.5	-0.1	-0.1	-0.5	0.3
Liver weight, left	0.7	1.2	2.0	-0.9	0.4	-1.2	1.0	-1.4	1.3
Liver weight, right	1.8	3.2	4.7	-0.1	1.6	-2.1	1.9	-2.2	1.9
Locomotor activity	0.2	0.3	0.5	0.2	0.3	-0.7	0.6	-0.6	0.7
Locomotor testing distance	0.3	0.8	0.9	0.9	1.0	-1.0	0.8	-0.8	0.9
Locomotor testing rearing	0.2	0.7	1.0	0.6	1.0	-0.8	0.7	-0.8	0.9
Locomotion in novel chamber	0.7	0.9	1.6	-0.6	0.6	-1.3	1.0	-0.8	1.2
Locomotion in novel chamber post-restriction	0.1	0.3	0.7	-0.6	0.1	-0.5	0.6	-0.5	0.9
Fecal boli incidents, locomotor time 1	0.2	0.6	1.4	-0.5	-0.5	0.6	-0.6	1.2	-1.0
Change in fecal boli incidents, locomotor task	0.8	0.9	1.2	-1.1	-1.0	0.9	-0.9	0.9	-0.7
Time >=10cm from walls, locomotor time 1	1.3	1.6	2.3	-1.0	-0.7	1.4	-1.3	1.5	-1.3
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.6	-0.1	-0.4	0.2	-0.2	0.3
Total resting periods, locomotor time 1	0.2	0.2	0.7	-0.8	-0.3	-0.4	0.2	-0.1	0.3
Rest time, locomotor task time 1	0.3	0.5	1.9	-1.4	-0.9	0.2	-0.4	0.3	-0.4
Distance moved, locomotor task time 1	0.0	0.1	0.4	0.6	-0.0	0.2	-0.3	-0.1	-0.2
Vertical activity count, locomotor time 1	0.0	0.3	0.7	-0.2	0.4	-0.6	0.5	-0.7	0.8
Time >=10cm from walls, locomotor time 2	0.4	1.0	1.6	-0.2	-0.5	1.2	-1.1	1.3	-1.2
Bouts of movement, locomotor time 2	0.5	1.6	2.6	-0.4	0.9	-1.5	1.5	-1.3	1.6
Total resting periods, locomotor time 2	0.3	1.2	2.0	-0.4	0.5	-1.3	1.3	-1.2	1.4
Rest time, locomotor task time 2	0.3	0.6	1.2	-1.1	-0.1	-0.8	0.8	-0.7	0.6
Distance moved, locomotor task time 2	0.6	0.8	1.6	1.2	-0.6	0.8	-1.0	0.5	-0.9
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.3	0.0	0.0	-0.3	-0.0	0.1
Light reinforcement 1	0.1	0.4	0.7	-0.1	0.6	-0.5	0.6	-0.8	0.7
Light reinforcement 2	0.3	0.8	1.2	0.4	1.0	-0.8	1.1	-0.9	0.8
Bone: marrow area	0.4	1.0	2.6	-1.6	-1.2	0.8	-0.9	0.8	-0.4
Bone: maximum diameter	0.8	1.5	2.7	-0.1	-0.8	1.6	-1.4	1.4	-1.4
Bone: maximum force	0.2	0.4	0.6	0.2	-0.5	0.8	-0.6	0.6	-0.7
Bone: maximum moment	0.2	0.3	0.5	-0.1	-0.6	0.7	-0.6	0.6	-0.6
Mean time between licks in bursts	0.2	1.1	2.6	-1.6	-1.6	0.5	-0.8	0.7	-0.4
Mean num. licks in bursts	0.0	0.1	0.3	0.5	0.0	-0.3	0.3	-0.3	-0.2
Cd content in liver	3.5	3.9	5.9	0.6	-1.4	2.2	-2.3	2.3	-2.4
Co content in liver	0.5	0.5	1.2	-0.6	-0.6	0.8	-0.7	1.1	-0.5
Cu content in liver	0.1	0.1	0.2	0.1	0.3	-0.3	0.4	-0.3	0.3
Fe content in liver	1.0	1.3	2.1	-0.5	-1.5	1.3	-1.1	1.1	-1.1
K content in liver	2.4	2.4	3.8	0.7	1.8	-1.8	1.9	-1.3	1.4
Mg content in liver	0.2	0.2	0.7	0.0	0.5	-0.6	0.8	-0.2	0.3
Mn content in liver	0.6	0.7	2.3	1.5	1.1	-0.1	0.3	0.5	-0.4
Na content in liver	3.8	4.2	6.9	0.5	1.9	-2.3	2.6	-2.2	2.0
Rb content in liver	0.7	0.9	1.2	-0.8	-1.0	0.9	-1.0	1.1	-0.9
Se content in liver	0.8	1.0	1.7	0.0	0.7	-1.2	1.3	-0.8	1.1
Sr content in liver	1.7	1.5	2.2	0.5	-1.2	1.4	-1.3	1.1	-1.5
Zn content in liver	0.2	0.3	0.5	0.6	0.7	-0.6	0.6	-0.1	0.2
Bone: minimum diameter	0.7	1.4	6.6	-2.6	-1.1	0.5	-0.6	0.5	0.1
Time in familiar zone, hab. session 1	1.6	1.8	2.7	1.4	1.6	-1.2	1.5	-1.3	1.0
Time in novel zone, hab. session 1	2.8	3.1	7.1	-2.7	-2.3	1.1	-1.6	1.3	-0.9
Total zone transitions, hab. session 1	3.5	4.9	6.5	0.9	2.2	-2.4	2.4	-2.5	2.5
Total locomotion distance, hab. session 1	4.0	5.6	7.4	0.6	2.2	-2.7	2.7	-2.7	2.5
Locomotion velocity, hab. session 1	4.1	5.8	7.4	1.3	2.5	-2.6	2.7	-2.7	2.5
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.3	-0.1	-0.0	0.2	-0.0	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.2	-0.3	0.2	-0.6	0.4	-0.1
Total zone transitions, hab. session 2	0.2	0.2	0.3	0.6	0.4	-0.6	0.4	-0.5	0.5
Total locomotion distance, hab. session 2	0.4	0.6	0.9	0.3	0.7	-0.9	0.8	-0.8	0.8
Locomotion velocity, hab. session 2	1.1	1.4	2.0	0.6	1.2	-1.4	1.3	-1.3	1.2
Novel to familiar place preference ratio	0.2	0.3	0.5	-0.1	0.4	-0.5	0.7	-0.7	0.6
Novelty place preference	0.2	0.3	0.5	-0.3	0.3	-0.5	0.7	-0.7	0.6
Time in novel zone, NPP test	0.4	0.5	0.7	-0.4	0.4	-0.7	0.8	-0.8	0.8
Total zone transitions, NPP test	0.4	0.6	2.5	1.6	1.0	-0.1	0.2	-0.2	0.0
Total locomotion distance, NPP test	0.8	1.1	1.6	1.1	1.3	-0.9	1.1	-1.0	0.8
Locomotion velocity, NPP test	0.7	1.0	2.0	1.4	1.3	-0.7	1.0	-0.8	0.6
Intraocular pressure	0.5	0.8	2.1	-1.3	-1.5	0.6	-0.9	0.1	-0.1
Delta distance traveled before/after self-admin	0.7	0.8	1.1	-0.5	0.9	-1.0	0.8	-0.8	1.0
Delta ambulatory time before/after self-admin	0.2	0.3	0.6	-0.2	0.6	-0.8	0.4	-0.5	0.7
Parametrial fat weight	0.2	0.5	2.3	-1.5	-0.6	0.3	-0.4	0.3	0.1
Pavlov. Cond. lever latency	1.0	1.2	1.6	-0.5	-1.2	1.3	-1.1	1.2	-1.2
Pavlov. Cond. magazine entry latency	0.7	0.9	1.3	0.9	1.1	-1.0	0.9	-0.9	0.9
Pavlov. Cond. change in total contacts	0.4	0.4	0.6	0.4	0.8	-0.8	0.6	-0.6	0.7
Pavlov. Cond. index score	1.8	2.2	2.9	1.2	1.7	-1.6	1.4	-1.5	1.5
Pavlov. Cond. latency score	1.2	1.6	2.1	1.1	1.4	-1.3	1.1	-1.2	1.2
Pavlov. Cond. lever contacts	1.0	1.2	1.5	0.8	1.2	-1.2	1.0	-1.1	1.1
Pavlov. Cond. magazine entry number	0.9	1.1	1.6	-0.8	-1.3	1.2	-1.0	1.0	-1.1
Pavlov. Cond. intertrial magazine entries	0.9	1.0	1.4	0.2	0.9	-1.2	1.2	-1.2	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.3	3.1	1.2	1.7	-1.6	1.4	-1.6	1.5
Pavlov. Cond. response bias	1.4	1.7	2.2	0.5	1.4	-1.4	1.3	-1.4	1.5
Pavlov. Cond. lever latency	0.1	0.1	0.4	0.6	0.5	-0.2	-0.1	-0.0	-0.0
Pavlov. Cond. magazine entry latency	1.0	1.4	3.0	-1.2	-1.7	1.1	-1.1	0.9	-0.8
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.0	0.0	-0.2	0.3	-0.3	0.2
Pavlov. Cond. index score	0.6	1.0	2.2	-1.1	-1.5	0.9	-0.8	0.7	-0.7
Pavlov. Cond. latency score	0.7	1.1	2.2	-0.8	-1.5	1.1	-1.0	0.9	-0.9
Pavlov. Cond. lever contacts	0.2	0.3	1.1	-1.0	-0.7	0.2	0.1	0.0	0.1
Pavlov. Cond. magazine entry number	1.0	1.3	2.6	0.8	1.6	-1.1	1.2	-1.0	1.0
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.3	-0.1	0.5	-0.3	0.3	-0.1	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	2.2	-1.1	-1.5	0.9	-0.8	0.7	-0.6
Pavlov. Cond. response bias	0.3	0.4	1.3	-1.2	-0.9	0.2	-0.0	0.1	0.1
Time in closed arm before self-admin	0.5	0.8	1.8	-0.0	-0.6	1.2	-1.4	0.7	-0.7
Time in closed arm after self-admin	0.4	0.5	1.4	1.2	1.2	0.1	0.3	-0.1	0.2
Time in open arm before self-admin	0.2	0.2	1.1	-1.1	-0.2	-0.1	0.3	0.1	0.0
Time in open arm after self-admin	0.8	0.8	2.6	-1.6	-0.4	-1.0	0.9	-0.4	0.7
Bone: periosteal estimation	0.3	0.7	1.3	-0.3	-0.6	1.2	-1.0	0.9	-0.8
Bone: periosteal perimeter	0.1	0.2	0.5	0.5	0.2	0.7	-0.3	0.5	-0.5
Bone: post-yield work	0.5	0.9	2.5	-1.6	-1.2	0.6	-0.6	0.7	-0.5
Progressive ratio test 1 active lever presses	0.5	0.8	3.7	-1.9	-0.8	-0.2	0.2	-0.6	0.5
Progressive ratio test 1 breakpoint	0.4	0.8	3.4	-1.8	-0.7	-0.2	0.2	-0.6	0.5
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.5	0.3	0.4	-0.1	0.0	-0.7	0.4
Progressive ratio test 2 active lever presses	0.4	0.6	2.3	-1.5	-0.2	-0.3	0.2	-0.7	0.6
Progressive ratio test 2 breakpoint	0.4	0.5	2.2	-1.5	-0.1	-0.4	0.2	-0.7	0.6
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.8	-0.9	-0.2	-0.2	-0.1	-0.5	0.3
Incentive Sensitization - Responses	0.1	0.3	1.4	-1.2	-0.3	0.2	-0.5	0.0	0.0
Incentive Sensitization - Breakpoint	0.1	0.3	1.4	-1.2	-0.3	0.2	-0.5	0.1	0.0
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.1	0.6	-0.4	0.4	-0.4	0.3
Progressive ratio	0.0	0.0	0.1	0.2	-0.3	0.2	-0.1	-0.2	-0.2
Food seeking constrained by brief footshock	0.2	0.3	0.5	0.7	-0.4	0.6	-0.7	-0.2	-0.2
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.0	0.4	-0.2	0.0	-0.2	0.2
Retroperitoneal fat weight	0.2	1.0	2.6	-1.6	-1.3	0.5	-0.9	0.7	-0.2
Reaction time number correct	0.1	0.5	0.8	-0.5	-0.9	0.7	-0.7	0.8	-0.6
Reaction time mean minus median	0.2	1.1	2.3	-1.3	-1.5	1.0	-1.0	0.5	-0.6
Reaction time mean minus median AUC	0.2	1.4	3.0	-1.2	-1.7	1.1	-1.2	0.5	-0.8
Reaction time num false alarms	1.6	2.7	3.8	1.0	1.9	-1.9	1.6	-1.6	1.6
Reaction time num false alarms AUC	1.2	2.8	3.7	1.1	1.9	-1.9	1.6	-1.7	1.7
Reaction time trials correct on left	0.1	0.5	0.8	-0.5	-0.9	0.7	-0.7	0.8	-0.6
Reaction time trials on left	0.2	0.6	0.9	-0.5	-1.0	0.8	-0.8	0.9	-0.7
Reaction time mean	0.9	1.9	2.8	-1.4	-1.7	1.3	-1.4	1.3	-1.2
Reaction time mean AUC	0.6	1.4	2.2	-1.5	-1.5	1.0	-1.2	1.0	-0.9
Median of all reaction times	1.1	1.8	2.3	-1.2	-1.5	1.2	-1.4	1.4	-1.2
Reaction time omissions	1.1	1.8	2.7	-0.2	-1.4	1.6	-1.5	1.3	-1.4
Reaction time false alarm rate	2.5	3.4	4.5	1.0	2.1	-2.1	1.8	-1.9	1.9
Reaction time premature initiation rate	0.3	0.5	0.9	0.2	0.9	-0.8	0.7	-0.6	0.7
Reaction time premature initiations	0.0	0.1	0.2	-0.1	0.4	-0.4	0.3	-0.3	0.5
Std. dev. reaction times	0.3	0.9	1.9	-1.1	-1.4	0.9	-1.0	0.5	-0.6
Reaction time trials completed	0.2	0.6	0.9	-0.5	-1.0	0.8	-0.8	0.9	-0.7
Reaction time trials AUC	0.2	0.9	1.4	-0.7	-1.2	1.0	-0.9	1.0	-0.8
Run reversals in cocaine runway, females	0.2	0.2	0.6	0.5	0.4	-0.3	0.2	-0.8	0.5
Run reversals in cocaine runway, males	1.3	1.4	2.3	0.2	-0.7	1.5	-1.5	1.1	-1.4
Latency to leave start box in cocaine runway	0.2	0.3	1.2	-1.1	-0.1	-0.2	0.5	-0.2	0.7
Latency to leave start box in cocaine runway, F	0.8	1.0	1.8	-0.7	0.8	-0.8	1.1	-1.0	1.4
Latency to leave start box in cocaine runway, M	1.1	1.1	1.9	-1.0	-1.4	0.9	-1.0	1.1	-0.7
Std. dev. time between licks in bursts	0.1	0.2	0.9	-0.9	-0.0	-0.4	0.3	-0.2	0.5
Total sessions with >9 infusions	0.2	0.2	1.0	-1.0	-0.4	0.3	-0.2	-0.3	-0.0
Short access day 1 total inactive lever presses	0.3	0.6	0.8	-0.3	0.7	-0.9	0.8	-0.8	0.9
Short access day 10 total inactive lever presses	0.1	0.8	4.1	2.0	0.8	0.0	-0.2	-0.2	0.0
Short access day 1 total infusions	0.8	1.7	2.5	-0.3	1.3	-1.2	1.4	-1.6	1.5
Short access day 10 total infusions	0.7	1.1	2.3	-0.1	1.0	-1.1	1.0	-1.5	1.2
Short access total infusions	0.1	0.1	0.3	-0.4	-0.0	0.1	-0.1	-0.5	0.1
Short access day 1 locomotion	0.9	1.5	2.3	-1.4	0.5	-1.2	1.0	-1.5	1.5
Short access day 10 total locomotion	0.1	0.6	1.0	-0.1	1.0	-0.8	0.8	-0.8	0.7
Short access total locomotion	0.3	0.5	1.2	-1.1	0.4	-0.4	0.4	-1.0	0.6
One hour access (0.3 mA shock)	0.8	0.9	4.4	-2.1	-0.8	-0.3	-0.1	-0.4	0.5
Compulsive drug intake	0.4	0.6	3.3	1.8	0.2	0.3	-0.1	0.1	-0.4
One hour access (shock baseline)	0.6	1.4	4.8	-2.2	0.1	-1.0	0.6	-1.0	1.2
Social response proportion	0.2	0.3	0.8	-0.9	-0.8	0.2	-0.1	0.3	-0.4
Social responses	0.6	0.7	1.1	-0.8	0.3	-0.9	0.9	-0.9	1.1
Social time	0.1	0.2	0.6	-0.6	-0.8	0.2	-0.3	0.2	-0.3
Soleus weight	2.4	7.2	22.6	4.8	3.6	-1.3	1.6	-1.6	0.8
Bone: stiffness	0.7	1.3	1.9	0.1	1.0	-1.2	1.4	-1.3	1.3
Tibialis anterior weight	0.9	3.1	15.2	3.9	1.6	-0.2	0.6	-0.6	-0.3
Time to tail flick, vehicle, before self-admin	0.4	0.5	2.4	-1.5	-0.8	0.1	-0.1	0.2	0.2
Time to tail flick, vehicle, after self-admin	0.4	0.8	1.6	0.1	0.8	-0.9	1.3	-1.0	1.0
Time to tail flick, test, before self-admin	0.5	0.6	1.3	0.1	-0.9	0.8	-1.1	0.7	-0.7
Time to tail flick, test, after self-admin	0.5	0.5	2.0	-1.4	-1.0	0.3	-0.2	-0.1	0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.5	1.1	1.0	0.6	-0.4	0.5	-0.8	0.4
Delta time to tail flick, test, before/after SA	0.4	0.5	1.0	-0.8	0.3	-0.6	1.0	-0.7	0.8
Tibia length	1.3	3.5	4.5	-1.8	-2.1	1.7	-2.0	2.0	-1.6
Ambulatory time before self-admin	0.2	0.6	0.8	-0.4	0.9	-0.9	0.8	-0.6	0.9
Ambulatory time after self-admin	1.3	2.0	3.1	-0.9	1.3	-1.7	1.3	-1.3	1.8
Bone: tissue strength	0.3	0.3	0.5	-0.5	0.4	-0.5	0.7	-0.6	0.7
Total heroin consumption	0.7	0.8	3.9	-2.0	-0.9	-0.1	-0.1	0.0	0.3
Bone: trabecular number	0.4	0.8	2.6	1.6	0.9	-0.3	0.6	-0.8	0.3
Bone: trabecular spacing	0.1	0.2	0.5	0.1	0.4	-0.7	0.5	-0.2	0.3
Bone: trabecular thickness	0.2	0.2	0.7	0.8	0.7	0.4	0.0	-0.3	0.1
Bone: trabecular tissue density	0.0	0.0	0.1	0.1	0.1	-0.0	0.1	-0.3	0.2
Water consumed over 24 hours	0.0	0.0	0.1	0.0	0.0	0.3	-0.1	0.1	-0.2
Number of responses in last shaping day	2.9	3.7	5.8	0.9	2.4	-2.1	1.9	-1.8	2.0