Hub : Genes

LOC134481501

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr13_52970420_52971211 0.06 0.04 7.4e-06 0.05 0.06 0.06 0.05 2.2e-05 6.3e-06 4.4e-06 9.8e-06
2 pVTA gene expression LOC134481501 0.24 0.03 0.0e+00 0.49 0.61 0.62 0.62 2.6e-44 3.5e-61 1.5e-63 2.7e-63
3 PL intron excision ratio chr13_52970420_52971211 0.04 0.03 5.2e-05 0.04 0.03 0.03 0.04 1.0e-04 1.6e-04 4.9e-04 7.5e-05
4 IC gene expression LOC134481501 0.63 0.11 0.0e+00 0.32 0.51 0.52 0.52 3.6e-14 2.2e-24 2.3e-25 3.5e-25
5 pVTA intron excision ratio chr13_52970420_52971211 0.03 0.02 2.4e-03 0.01 0.03 0.02 0.02 5.1e-02 2.2e-03 9.4e-03 1.1e-02
6 pVTA intron excision ratio chr13_52970581_52971211 0.03 0.02 6.9e-03 0 0.02 0.01 0.01 1.5e-01 7.9e-03 5.5e-02 4.7e-02
7 Brain gene expression LOC134481501 0.55 0.12 0.0e+00 0.56 0.63 0.64 0.64 6.4e-63 1.8e-75 2.9e-78 2.4e-78
8 OFC gene expression LOC134481501 0.61 0.16 2.4e-10 0.27 0.3 0.27 0.28 4.0e-07 8.3e-08 4.9e-07 2.4e-07
9 NAcc gene expression LOC134481501 0.19 0.03 0.0e+00 0.4 0.01 0.55 0.42 7.5e-66 2.5e-02 3.3e-100 1.5e-69
10 PL gene expression LOC134481501 0.44 0.1 0.0e+00 0.32 0.49 0.48 0.49 7.0e-36 3.0e-60 9.2e-59 4.2e-60
11 NAcc intron excision ratio chr13_52970420_52971211 0.05 0.04 2.1e-05 0.02 0.03 0.02 0.01 3.8e-04 8.1e-05 1.5e-04 1.1e-02
12 LHb gene expression LOC134481501 0.72 0.11 2.8e-16 0.36 0.41 0.4 0.41 2.3e-09 8.2e-11 1.5e-10 9.4e-11
13 BLA gene expression LOC134481501 0.7 0.11 0.0e+00 0.34 0.46 0.48 0.45 1.8e-18 5.3e-27 4.7e-28 2.3e-26
14 pVTA mRNA stability LOC134481501 0.1 0.05 4.4e-08 0.04 0.09 0.08 0.09 3.4e-04 1.3e-07 3.4e-07 1.9e-07
15 NAcc intron excision ratio chr13_52970581_52971211 0.05 0.06 1.2e-04 0.02 0.02 0.02 0 6.9e-04 4.5e-04 1.0e-03 8.2e-02
16 PL intron excision ratio chr13_52970581_52971211 0.04 0.03 7.7e-05 0.04 0.03 0.03 0.03 2.2e-05 1.9e-04 1.2e-04 6.0e-04
17 IL gene expression LOC134481501 0.52 0.15 3.1e-09 0.22 0.27 0.26 0.26 4.6e-06 3.2e-07 4.6e-07 4.4e-07
18 RMTg gene expression LOC134481501 0.29 0.18 4.9e-05 0.2 0.16 0.12 0.14 6.9e-06 5.2e-05 4.1e-04 1.4e-04
19 Liver gene expression LOC134481501 0.37 0.14 0.0e+00 0.24 0.26 0.25 0.26 3.3e-26 2.9e-28 2.9e-27 2.8e-28
20 Eye gene expression LOC134481501 0.44 0.23 1.6e-03 0.21 0.1 0.08 0.1 4.0e-04 1.3e-02 2.6e-02 1.3e-02
21 Adipose gene expression LOC134481501 0.25 0.12 0.0e+00 0.16 0.16 0.15 0.16 1.9e-17 1.8e-17 1.5e-16 1.9e-17

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density3.45.87.1-2.6-2.6-2.4-2.7-2.52.5-2.5-2.5-2.6-2.6-2.4-2.6-2.6-2.72.42.1-2.5-2.1-2.0-1.6-2.2
Area under the delay curve0.30.31.00.90.60.80.70.8-0.80.20.60.50.50.60.40.30.5-0.6-1.00.20.0-0.40.7-0.2
BMI with tail2.89.613.8-2.7-3.3-2.9-3.3-3.03.1-3.4-3.2-3.0-3.3-2.8-3.5-3.2-3.32.72.2-3.5-3.7-3.2-2.0-3.2
BMI without tail2.16.59.4-3.1-2.9-2.8-2.9-2.92.9-2.3-2.8-2.5-2.6-2.5-2.6-2.4-2.72.42.6-2.4-2.0-1.6-2.2-1.7
Body weight4.720.628.9-3.7-4.8-4.1-4.8-4.24.3-5.2-4.5-4.5-4.8-4.2-5.1-4.9-4.84.13.0-5.2-5.4-5.0-2.8-5.1
Weight adjusted by age0.20.21.1-0.6-0.1-0.40.1-0.30.20.4-0.00.10.0-0.20.30.40.10.20.80.61.01.1-0.20.9
Bone surface5.710.313.0-3.6-3.6-3.3-3.5-3.43.4-3.2-3.3-3.5-3.5-3.2-3.4-3.3-3.53.12.9-3.3-2.5-2.5-2.2-2.8
Bone volume4.37.79.6-3.0-3.1-2.8-3.1-2.92.9-2.8-2.9-3.0-3.0-2.7-2.9-2.9-3.12.62.5-2.9-2.3-2.2-1.8-2.5
Breakpoint value in progressive ratio session0.00.00.30.60.2-0.20.20.3-0.3-0.00.30.00.20.10.20.10.3-0.1-0.20.20.10.0-0.10.1
Number of licking bursts0.10.10.4-0.2-0.1-0.1-0.3-0.30.3-0.3-0.4-0.2-0.2-0.4-0.3-0.3-0.30.40.2-0.4-0.3-0.4-0.6-0.3
Context. condit. distance diff. score2.22.74.01.21.61.61.61.4-1.51.81.61.81.61.61.81.81.5-1.6-1.31.91.92.01.31.7
Locomotion velocity, session 10.40.40.6-0.6-0.6-0.5-0.7-0.60.6-0.8-0.7-0.7-0.7-0.8-0.7-0.7-0.70.80.4-0.7-0.7-0.7-0.4-0.7
Locomotion distance, session 10.20.20.5-0.6-0.4-0.2-0.5-0.50.5-0.4-0.5-0.5-0.4-0.6-0.4-0.5-0.40.60.3-0.5-0.2-0.3-0.7-0.3
Locomotion velocity, session 20.30.40.6-0.8-0.7-0.7-0.7-0.70.7-0.6-0.7-0.7-0.6-0.7-0.6-0.7-0.60.70.6-0.6-0.4-0.5-0.6-0.4
Locomotion distance, session 20.40.51.9-1.4-0.7-0.8-0.6-0.90.9-0.1-0.7-0.6-0.4-0.8-0.2-0.3-0.30.81.2-0.10.40.5-1.20.6
Locomotion velocity, session 30.00.00.2-0.3-0.0-0.00.0-0.10.10.2-0.00.10.1-0.10.10.10.10.10.10.20.40.4-0.40.4
Locomotion distance, session 30.40.51.8-1.3-0.5-0.7-0.5-0.80.70.2-0.5-0.3-0.2-0.60.10.0-0.20.61.10.30.81.1-1.01.0
Stereotopy head waving bouts, day 30.20.20.50.50.50.30.50.5-0.50.30.50.70.50.40.50.60.4-0.4-0.30.60.30.40.50.4
Stereotopy head waving duration, day 30.50.51.21.10.80.80.80.9-0.90.30.80.90.60.80.50.60.6-0.8-1.00.50.1-0.11.1-0.0
Locomotion velocity, session 70.70.82.3-1.5-1.2-1.0-1.0-1.11.1-0.7-0.9-0.8-1.1-0.9-0.7-0.7-1.00.90.9-0.5-0.20.0-0.1-0.2
Locomotion distance, session 70.10.10.7-0.9-0.3-0.1-0.1-0.40.30.1-0.1-0.1-0.2-0.20.10.1-0.10.20.20.30.60.6-0.00.6
Stereotopy head waving bouts, day 72.42.74.02.01.81.91.71.9-1.81.51.81.71.61.81.51.41.6-1.8-2.01.51.21.01.90.9
Stereotopy head waving duration, day 71.51.82.11.51.41.41.41.4-1.41.31.41.41.41.41.31.31.3-1.4-1.41.31.11.01.40.9
Locomotion velocity, session 80.50.71.30.40.70.70.70.7-0.70.90.70.90.90.60.90.90.9-0.6-0.61.01.01.20.31.1
Locomotion distance, session 81.92.76.50.61.51.41.51.1-1.12.11.31.71.71.21.92.01.7-1.2-0.82.12.42.50.32.4
Degree of sensitization distance0.20.20.80.0-0.3-0.1-0.2-0.10.1-0.6-0.2-0.3-0.4-0.3-0.4-0.4-0.40.3-0.3-0.5-0.7-0.90.2-0.8
Degree of sensitization stereotypy2.62.84.32.11.81.91.71.9-1.91.51.81.71.71.91.61.51.6-1.8-2.01.51.21.01.90.9
Conditioned locomotion0.91.02.6-0.3-0.9-0.5-0.8-0.60.7-1.3-0.8-1.0-0.9-0.8-1.2-1.2-1.00.80.2-1.3-1.5-1.6-0.4-1.5
Cocaine response after cond. corrected0.10.20.8-0.10.20.10.30.1-0.10.50.20.30.30.30.40.40.4-0.40.00.40.90.60.20.7
Cocaine response after cond. not corrected0.30.31.1-0.9-0.4-0.8-0.3-0.70.70.2-0.5-0.3-0.2-0.4-0.00.1-0.10.41.10.20.70.7-0.90.8
Cocaine response before conditioning0.81.02.9-1.3-0.9-1.4-0.9-1.21.1-0.5-1.0-0.8-0.8-1.2-0.6-0.4-0.81.21.6-0.3-0.40.2-1.70.2
Saline control response0.30.41.5-0.7-0.4-1.0-0.4-0.70.6-0.3-0.6-0.4-0.4-0.8-0.2-0.2-0.30.81.20.0-0.10.3-1.20.4
Bone: connectivity density5.78.910.6-3.0-3.2-3.0-3.2-3.03.0-3.2-3.0-3.2-3.2-3.0-3.2-3.2-3.33.02.5-3.1-2.5-2.6-2.1-2.8
Bone: cortical apparent density0.60.81.50.60.90.80.90.7-0.71.10.81.01.00.81.11.11.0-0.7-0.51.11.11.20.31.2
Bone: cortical area3.65.57.2-2.5-2.7-2.3-2.5-2.42.4-2.3-2.4-2.4-2.5-2.2-2.6-2.4-2.52.11.9-2.5-2.3-2.1-1.5-2.2
Bone: cortical porosity3.74.08.3-2.3-2.1-2.2-1.9-2.32.2-1.6-2.2-2.2-1.8-2.2-1.8-1.8-1.72.22.4-1.8-1.2-1.1-2.9-0.9
Bone: cortical porosity2.62.97.2-2.0-1.8-2.0-1.5-2.01.9-1.3-1.9-1.8-1.4-1.9-1.5-1.4-1.31.92.2-1.4-0.7-0.9-2.7-0.6
Bone: cortical thickness1.42.33.2-1.4-1.7-1.4-1.6-1.41.4-1.6-1.5-1.6-1.6-1.4-1.7-1.6-1.61.31.0-1.8-1.7-1.7-0.9-1.7
Bone: cortical thickness1.51.73.3-1.8-1.5-1.6-1.4-1.61.6-1.0-1.5-1.3-1.3-1.4-1.2-1.1-1.21.31.7-1.0-0.7-0.4-1.5-0.5
Bone: cortical tissue density0.60.81.50.60.90.80.90.7-0.71.10.81.01.00.71.11.11.0-0.7-0.51.11.11.20.31.2
Condit. Reinf. active minus inactive responses0.50.61.0-0.9-0.8-0.8-0.8-0.80.8-0.7-0.7-1.0-0.8-0.7-0.8-0.9-0.80.70.8-0.8-0.5-0.6-0.3-0.6
Condit. Reinf. active-inactive response ratio0.20.20.80.2-0.20.0-0.20.1-0.0-0.5-0.0-0.3-0.40.1-0.4-0.5-0.4-0.1-0.3-0.6-0.6-0.80.8-0.9
Condit. Reinf. active responses0.70.92.3-1.5-1.1-1.2-1.0-1.21.2-0.5-1.0-1.2-0.9-1.0-0.7-0.8-0.81.01.5-0.50.00.1-0.90.1
Condit. Reinf. inactive responses0.70.93.0-1.6-0.9-1.3-0.8-1.21.1-0.1-0.9-0.9-0.6-1.0-0.3-0.4-0.51.01.7-0.00.50.8-1.50.8
Incentive salience index mean1.41.73.2-1.8-1.4-1.5-1.3-1.51.5-1.0-1.4-1.6-1.3-1.4-1.1-1.2-1.21.31.8-1.0-0.5-0.6-1.2-0.5
Condit. Reinf. lever presses0.40.62.2-1.3-0.8-1.0-0.6-1.01.0-0.3-0.8-0.9-0.6-0.8-0.4-0.5-0.50.81.5-0.30.30.1-0.90.3
Condit. Reinf. active minus inactive responses0.81.03.8-1.6-0.7-1.3-0.8-1.21.10.3-0.8-0.4-0.4-0.8-0.00.0-0.40.81.90.40.71.5-1.61.3
Condit. Reinf. active-inactive response ratio0.40.42.2-0.30.3-0.00.20.0-0.10.90.30.50.50.20.70.70.5-0.20.51.01.01.5-0.21.3
Condit. Reinf. active responses1.21.65.5-2.0-1.2-1.7-1.3-1.61.5-0.2-1.3-0.9-0.8-1.3-0.5-0.4-0.81.32.3-0.10.31.0-2.10.9
Condit. Reinf. inactive responses2.43.15.6-2.1-1.9-2.1-1.9-2.01.9-1.5-1.9-1.7-1.6-2.0-1.5-1.5-1.62.12.2-1.3-1.1-0.7-2.4-0.7
Condit. Reinf. lever presses1.31.74.7-2.2-1.3-1.6-1.4-1.71.6-0.4-1.4-1.1-1.0-1.5-0.7-0.6-1.01.52.1-0.30.00.8-2.00.6
Condit. Reinf. lever reinforcers received1.11.55.5-2.0-1.0-1.6-1.1-1.51.40.2-1.1-0.6-0.6-1.2-0.2-0.1-0.61.22.40.30.71.5-2.01.3
Conditioned reinforcement - actives1.22.03.4-1.8-1.6-1.4-1.6-1.71.6-1.4-1.5-1.7-1.5-1.6-1.4-1.4-1.51.51.3-1.2-1.0-0.9-1.1-0.8
Conditioned reinforcement - inactives4.16.17.8-2.2-2.6-2.5-2.7-2.42.5-2.8-2.5-2.4-2.6-2.6-2.5-2.6-2.62.72.2-2.3-2.7-2.1-1.7-2.1
Conditioned locomotion0.40.51.1-1.0-0.8-0.6-0.8-0.90.8-0.7-0.8-0.9-0.8-0.7-0.7-0.7-0.80.70.5-0.7-0.4-0.6-0.6-0.5
Patch foraging indifference point 0 sec0.81.52.51.31.41.61.51.3-1.31.11.21.31.31.21.21.21.3-1.2-1.51.11.10.60.80.9
Patch foraging indifference point AUC0.10.10.50.60.50.70.20.5-0.40.20.30.50.30.30.20.10.2-0.2-0.70.20.00.10.3-0.1
Delay disc. indifference point, 0s delay1.41.63.61.81.41.81.21.5-1.50.71.41.11.01.50.80.71.0-1.5-1.90.50.4-0.21.9-0.2
Delay disc. indifference point, 16s delay0.50.51.21.00.70.70.80.9-0.90.40.80.70.60.80.50.50.7-0.8-1.00.40.2-0.11.10.0
Delay disc. indifference point, 2s delay0.30.31.70.60.10.7-0.00.3-0.2-0.6-0.0-0.1-0.2-0.0-0.5-0.5-0.20.1-0.9-0.7-1.0-1.30.1-1.2
Delay disc. indifference point, 24s delay0.40.51.30.50.61.00.80.7-0.70.60.70.60.60.80.60.60.6-0.8-0.90.50.60.21.10.3
Delay disc. indifference point, 4s delay0.70.81.41.11.11.21.11.1-1.00.70.90.81.00.80.80.81.1-0.7-1.10.70.70.20.10.5
Delay disc. indifference point, 8s delay0.00.00.0-0.1-0.1-0.1-0.1-0.00.0-0.10.0-0.0-0.10.0-0.0-0.1-0.1-0.00.0-0.1-0.1-0.10.2-0.1
Indifference point function ln k0.20.31.70.2-0.3-0.1-0.20.00.0-0.8-0.1-0.4-0.4-0.1-0.6-0.6-0.40.0-0.3-0.8-0.9-1.30.6-1.1
Indifference point function log k0.20.31.70.2-0.3-0.1-0.20.00.0-0.8-0.1-0.4-0.4-0.1-0.6-0.6-0.40.0-0.3-0.8-0.9-1.30.6-1.1
Patch foraging total patch changes 0 sec0.61.21.81.01.21.31.31.1-1.11.11.11.11.21.01.11.11.2-1.0-1.11.11.10.80.51.0
Patch foraging total patch changes 12 sec0.81.11.51.01.21.21.00.9-1.01.20.91.21.20.71.11.11.2-0.7-0.81.21.11.2-0.31.2
Patch foraging total patch changes 18 sec1.62.43.11.31.71.61.61.4-1.51.71.51.81.61.51.61.61.5-1.5-1.41.71.71.60.91.5
Patch foraging total patch changes 24 sec0.50.91.30.81.00.90.90.8-0.81.10.91.21.00.91.01.10.9-0.9-0.71.01.11.10.61.0
Patch foraging total patch changes 6 sec1.32.02.81.61.61.71.51.6-1.61.31.51.51.41.51.31.31.4-1.5-1.61.31.10.81.30.8
Patch foraging time to switch 0 sec0.71.42.51.01.10.81.30.9-1.01.51.11.01.31.11.41.41.3-1.2-0.41.41.51.50.61.6
Patch foraging water rate 0 sec0.00.00.20.1-0.00.2-0.00.2-0.1-0.20.10.1-0.10.1-0.1-0.2-0.1-0.1-0.5-0.2-0.2-0.30.4-0.4
Patch foraging water rate 12 sec0.10.20.7-0.8-0.6-0.6-0.5-0.50.5-0.3-0.4-0.5-0.6-0.2-0.4-0.4-0.60.20.5-0.4-0.2-0.20.3-0.3
Patch foraging water rate 18 sec0.50.81.41.00.91.00.91.0-1.00.81.00.80.91.00.90.80.9-1.0-1.20.80.70.51.00.5
Patch foraging water rate 24 sec0.00.00.2-0.4-0.3-0.2-0.1-0.30.2-0.1-0.2-0.2-0.2-0.1-0.2-0.1-0.10.10.2-0.30.1-0.2-0.0-0.1
Patch foraging water rate 6 sec0.40.60.9-0.9-0.8-0.6-0.9-0.70.7-0.8-0.8-0.8-0.8-0.7-0.8-0.9-0.80.70.4-0.9-0.9-0.7-0.5-0.8
Seeking ratio, delayed vs. immediate footshock3.13.84.71.72.11.82.11.9-2.02.12.01.92.02.02.12.22.0-2.0-1.52.02.01.81.71.8
Distance traveled before self-admin0.40.51.71.30.70.60.71.0-1.00.20.90.70.60.80.60.30.6-0.7-0.90.50.1-0.11.3-0.1
Distance traveled after self-admin1.61.94.3-1.3-1.6-2.1-1.3-1.31.3-1.5-1.4-1.5-1.3-1.3-1.3-1.4-1.21.31.5-1.3-1.3-1.3-1.1-1.0
Extensor digitorum longus weight1.35.06.7-2.2-2.3-2.1-2.4-2.32.3-2.2-2.4-2.3-2.2-2.4-2.3-2.2-2.32.41.9-2.2-2.1-1.9-2.6-1.8
Bone: elastic displacement0.50.60.90.70.80.70.80.7-0.70.80.70.80.80.60.90.90.8-0.6-0.60.90.80.90.10.9
Bone: elastic work0.70.91.20.70.91.00.90.8-0.91.10.91.11.00.91.01.11.0-0.9-0.81.11.11.10.61.1
Bone: endosteal estimation0.10.30.6-0.8-0.7-0.2-0.6-0.50.5-0.4-0.4-0.6-0.6-0.2-0.6-0.6-0.60.10.2-0.6-0.3-0.40.6-0.6
Bone: endosteal perimeter1.94.06.5-1.7-2.1-1.7-2.0-1.71.8-2.3-1.8-2.1-2.2-1.7-2.3-2.2-2.31.71.1-2.4-2.3-2.4-0.5-2.5
Epididymis fat weight1.65.49.0-1.6-2.3-2.1-2.2-2.02.1-2.7-2.3-2.3-2.4-2.2-2.6-2.5-2.42.21.5-2.6-3.0-2.8-1.7-2.7
Delta time in closed arm before/after self-admin0.30.20.90.80.20.3-0.10.4-0.3-0.50.10.2-0.10.2-0.3-0.3-0.1-0.2-0.5-0.5-0.8-1.00.7-0.9
Delta time in open arm before/after self-admin0.80.81.10.90.91.00.90.9-0.91.00.90.91.00.81.00.90.9-0.8-1.01.00.80.90.60.9
Diff in mean of infusions in LGA sessions0.50.71.2-0.4-0.7-0.6-1.0-0.70.7-0.9-0.8-1.0-0.9-0.9-0.8-0.9-0.91.00.6-0.7-1.1-0.7-0.8-0.8
Delay discount exponential model param0.40.51.1-1.0-0.8-1.0-0.8-0.90.9-0.4-0.8-0.6-0.7-0.7-0.5-0.5-0.70.71.1-0.4-0.20.2-0.8-0.0
Extinction: sum of active levers before priming0.91.01.31.11.00.71.11.1-1.10.81.11.11.01.01.01.10.9-1.0-1.01.00.90.91.10.7
Active lever presses in extinction session 60.20.20.60.40.40.20.40.4-0.40.50.40.60.40.40.40.70.3-0.4-0.30.50.20.80.10.4
Bone: final force0.30.51.6-1.3-1.0-0.7-0.9-0.90.9-0.4-0.8-0.7-0.8-0.6-0.7-0.6-0.80.60.7-0.6-0.6-0.1-0.5-0.3
Bone: final moment0.30.51.5-1.2-1.0-0.6-0.8-0.90.9-0.4-0.8-0.7-0.7-0.6-0.7-0.6-0.70.60.7-0.6-0.5-0.1-0.5-0.3
Food consumed during 24 hour testing period1.21.62.3-1.1-1.2-1.3-1.2-1.21.2-1.5-1.3-1.3-1.3-1.4-1.3-1.3-1.31.41.1-1.4-1.2-1.3-1.5-1.3
Glucose0.50.72.4-1.4-0.7-1.1-0.7-1.11.00.2-0.8-0.3-0.4-0.8-0.10.2-0.40.81.50.30.21.2-1.51.0
Heart weight1.01.52.81.51.31.21.31.4-1.41.11.41.21.21.51.11.01.2-1.5-1.31.00.90.61.70.6
Delay discount hyperbolic model param0.30.30.9-0.9-0.6-0.8-0.6-0.80.7-0.2-0.6-0.5-0.5-0.5-0.3-0.3-0.50.51.0-0.2-0.00.4-0.50.2
Intermittent access intake day 1-15 change0.00.10.40.20.10.1-0.10.2-0.1-0.40.1-0.1-0.10.0-0.1-0.3-0.10.0-0.1-0.2-0.5-0.60.6-0.5
Intermittent access intake escalation0.10.20.6-0.3-0.3-0.3-0.4-0.20.2-0.6-0.3-0.4-0.4-0.3-0.4-0.5-0.40.30.4-0.4-0.6-0.80.0-0.5
Intermittent access intake escalation 20.70.82.21.01.01.30.71.1-1.10.51.00.60.70.80.80.50.6-0.7-1.20.90.20.21.50.2
Intermitt. access day 1 inactive lever presses2.07.79.8-2.9-3.0-3.1-3.1-3.03.0-2.8-2.9-2.8-3.0-3.0-2.7-2.9-3.03.03.0-2.4-2.3-1.7-2.2-1.9
Intermitt. access day 15 inactive lever presses1.53.04.5-1.6-1.7-1.7-2.1-1.81.8-1.8-1.8-1.9-2.0-1.9-1.7-2.0-2.01.91.7-1.5-1.6-1.2-0.9-1.5
Intermitt. access escalation Index1.11.53.4-1.6-1.3-1.7-1.4-1.51.5-0.9-1.2-1.2-1.4-1.3-0.9-0.9-1.41.31.8-0.6-0.60.1-0.8-0.3
Intermittent access day 1 total infusions1.42.33.1-1.6-1.5-1.6-1.7-1.71.7-1.5-1.6-1.7-1.5-1.7-1.4-1.4-1.61.81.5-1.2-1.2-0.9-1.7-0.9
Intermittent access day 15 total infusions1.21.82.1-1.4-1.3-1.4-1.4-1.41.4-1.4-1.4-1.4-1.3-1.4-1.3-1.3-1.31.41.4-1.3-1.1-1.2-1.2-1.0
Intermittent access terminal intake (last 3 days)0.81.01.9-0.6-0.9-0.6-1.2-0.80.9-1.3-0.9-1.2-1.1-1.0-1.0-1.2-1.21.00.4-1.0-1.4-1.3-0.3-1.2
Intermittent access total infusions2.32.73.2-1.7-1.7-1.6-1.8-1.81.8-1.7-1.7-1.8-1.7-1.8-1.6-1.6-1.71.81.5-1.5-1.6-1.3-1.6-1.2
Intermittent access day 1 locomotion3.13.95.0-2.2-2.1-2.2-2.2-2.22.2-2.0-2.2-2.0-2.0-2.1-1.9-1.9-2.02.11.9-1.8-1.4-1.3-2.1-1.2
Intermittent access day 15 total locomotion0.20.40.8-0.4-0.4-0.4-0.7-0.60.6-0.8-0.7-0.6-0.6-0.7-0.7-0.6-0.60.70.4-0.7-0.8-0.9-0.9-0.7
Intermittent access total locomotion2.12.53.7-1.5-1.4-1.4-1.6-1.71.7-1.6-1.7-1.7-1.5-1.8-1.6-1.5-1.51.81.4-1.5-1.4-1.4-1.9-1.1
Intermittent access standard deviation1.32.84.5-1.4-1.7-1.3-1.9-1.51.6-2.0-1.6-1.8-1.8-1.8-1.7-1.9-1.81.81.0-1.6-2.1-1.8-1.1-1.6
Left kidney weight0.62.63.5-1.1-1.7-1.5-1.7-1.51.5-1.8-1.6-1.7-1.6-1.6-1.8-1.9-1.61.51.1-1.9-1.8-1.8-1.4-1.7
Right kidney weight1.46.57.8-2.7-2.7-2.5-2.8-2.62.6-2.7-2.6-2.8-2.6-2.6-2.6-2.6-2.62.62.2-2.6-2.5-2.1-2.1-2.2
Cocaine induced anxiety0.10.20.4-0.6-0.5-0.6-0.4-0.50.5-0.2-0.4-0.3-0.4-0.4-0.2-0.2-0.40.40.7-0.0-0.00.3-0.30.1
Post-drug Anxiety0.10.10.6-0.5-0.3-0.6-0.1-0.30.30.2-0.2-0.1-0.1-0.30.20.1-0.00.30.80.30.30.6-0.40.6
Baseline Anxiety0.30.30.70.80.70.70.60.8-0.70.30.70.60.60.60.50.50.6-0.6-0.80.40.20.00.70.1
Tail length1.24.77.8-2.8-2.4-2.7-2.4-2.62.5-1.8-2.4-2.2-2.1-2.3-2.0-1.9-2.12.22.7-1.8-1.1-0.9-2.3-0.9
Length with tail1.35.67.3-1.9-2.4-2.2-2.5-2.12.1-2.7-2.3-2.5-2.4-2.3-2.6-2.7-2.42.21.6-2.7-2.7-2.6-1.6-2.6
Length without tail1.44.514.1-0.3-1.7-0.9-1.8-1.01.1-2.8-1.5-2.0-2.0-1.4-2.4-2.7-2.01.4-0.2-2.8-3.4-3.8-0.2-3.6
Times rat made contact with spout0.40.40.60.50.70.50.60.6-0.60.60.70.70.50.60.70.70.5-0.6-0.30.80.70.70.80.6
Lifetime Intake2.42.93.4-1.7-1.7-1.7-1.8-1.81.8-1.8-1.8-1.8-1.7-1.8-1.7-1.7-1.71.81.6-1.6-1.6-1.5-1.8-1.2
Liver weight, left6.410.712.5-3.2-3.5-3.5-3.4-3.33.4-3.4-3.4-3.5-3.5-3.3-3.4-3.3-3.43.33.1-3.3-2.9-2.8-2.5-2.8
Liver weight, right6.110.712.7-3.1-3.4-3.2-3.6-3.23.3-3.4-3.4-3.5-3.4-3.4-3.4-3.4-3.43.42.8-3.3-3.4-2.8-2.8-2.9
Locomotor activity0.40.61.6-0.9-0.7-0.8-0.8-0.80.8-0.7-0.8-0.7-0.7-1.0-0.6-0.7-0.71.10.8-0.4-0.5-0.3-1.2-0.2
Locomotor testing distance0.40.81.7-0.3-0.7-0.7-0.8-0.60.6-1.1-0.8-0.9-0.8-1.0-0.9-1.0-0.91.10.3-0.9-1.3-1.2-0.9-1.1
Locomotor testing rearing0.20.41.1-0.7-0.5-0.9-0.6-0.70.7-0.3-0.6-0.5-0.5-0.8-0.3-0.3-0.50.91.1-0.0-0.20.3-1.00.2
Locomotion in novel chamber0.40.51.1-0.4-0.5-0.3-0.8-0.50.5-0.8-0.6-0.9-0.7-0.7-0.7-1.0-0.70.80.5-0.7-1.1-1.0-0.5-0.8
Locomotion in novel chamber post-restriction1.11.93.11.01.51.81.51.3-1.31.61.31.41.41.41.41.51.4-1.4-1.21.41.51.20.91.3
Fecal boli incidents, locomotor time 10.10.10.8-0.10.2-0.10.1-0.10.00.50.0-0.00.30.10.30.20.3-0.10.50.20.90.6-0.40.6
Change in fecal boli incidents, locomotor task2.12.12.71.11.51.61.61.4-1.41.51.51.51.51.41.51.61.5-1.4-1.31.51.31.31.01.4
Time >=10cm from walls, locomotor time 15.76.17.02.22.52.62.62.5-2.52.62.52.42.62.52.62.62.6-2.5-2.32.52.52.21.82.2
Bouts of movement, locomotor time 11.21.42.3-1.0-1.2-0.9-1.4-1.11.1-1.3-1.2-1.2-1.3-1.1-1.3-1.5-1.31.10.7-1.4-1.2-1.2-0.6-1.4
Total resting periods, locomotor time 10.20.30.5-0.4-0.5-0.2-0.6-0.50.5-0.5-0.5-0.5-0.5-0.4-0.6-0.7-0.50.40.2-0.7-0.4-0.6-0.3-0.6
Rest time, locomotor task time 10.60.81.40.80.91.20.90.8-0.91.00.90.80.91.00.80.81.0-1.0-1.00.71.00.60.60.7
Distance moved, locomotor task time 10.20.21.3-0.6-0.4-0.9-0.2-0.50.5-0.2-0.4-0.4-0.4-0.5-0.20.1-0.40.61.10.0-0.30.2-0.50.2
Vertical activity count, locomotor time 10.51.21.7-1.1-1.1-1.1-1.1-1.21.2-1.0-1.2-1.1-1.2-1.3-1.0-1.0-1.21.31.3-0.9-1.1-0.6-1.0-0.7
Time >=10cm from walls, locomotor time 21.21.82.41.51.51.41.51.5-1.51.31.41.21.41.31.41.41.5-1.3-1.21.31.20.90.91.0
Bouts of movement, locomotor time 22.84.56.2-1.4-2.1-2.2-2.2-1.91.9-2.5-2.1-2.0-2.1-2.1-2.3-2.5-2.12.11.7-2.4-2.4-2.4-1.7-2.2
Total resting periods, locomotor time 22.03.55.1-1.1-1.9-1.8-2.0-1.61.6-2.2-1.8-1.7-1.9-1.8-2.0-2.2-1.91.81.3-2.1-2.3-2.2-1.4-2.1
Rest time, locomotor task time 20.50.60.90.90.70.70.90.8-0.80.70.80.90.90.80.80.70.9-0.8-0.80.70.70.50.40.6
Distance moved, locomotor task time 20.40.50.9-0.8-0.6-0.7-0.7-0.70.7-0.6-0.7-0.9-0.8-0.7-0.7-0.6-0.70.71.0-0.6-0.6-0.4-0.5-0.5
Vertical activity count, locomotor time 22.12.93.9-1.4-1.5-1.1-1.8-1.51.6-1.9-1.7-1.8-1.8-1.7-1.9-1.9-1.81.71.1-1.9-2.0-1.9-1.2-1.9
Light reinforcement 12.45.88.72.02.52.32.42.1-2.22.82.32.42.62.12.72.62.5-2.1-1.82.83.02.91.12.8
Light reinforcement 22.33.65.21.51.91.81.91.7-1.72.31.82.02.01.92.02.01.9-1.9-1.32.02.12.11.42.0
Bone: marrow area0.10.20.5-0.7-0.6-0.2-0.5-0.40.4-0.3-0.3-0.5-0.6-0.2-0.5-0.6-0.60.10.2-0.5-0.3-0.30.6-0.6
Bone: maximum diameter2.85.38.1-1.8-2.4-2.0-2.3-2.02.0-2.6-2.2-2.4-2.5-2.0-2.6-2.6-2.52.01.3-2.7-2.7-2.8-0.9-2.8
Bone: maximum force1.52.65.9-2.4-2.0-1.8-1.8-2.01.9-1.2-1.8-1.7-1.7-1.6-1.5-1.4-1.71.51.8-1.3-1.0-0.5-1.4-0.7
Bone: maximum moment1.32.35.3-2.3-1.8-1.7-1.7-1.81.8-1.1-1.6-1.6-1.5-1.5-1.4-1.3-1.51.41.7-1.2-0.8-0.4-1.4-0.6
Mean time between licks in bursts0.10.20.5-0.6-0.5-0.5-0.5-0.60.6-0.3-0.5-0.5-0.4-0.5-0.4-0.4-0.40.40.6-0.40.0-0.0-0.7-0.0
Mean num. licks in bursts0.20.40.90.40.50.30.60.5-0.60.70.70.60.50.60.70.70.5-0.6-0.30.80.70.80.90.7
Cd content in liver1.71.95.42.21.51.81.31.8-1.70.51.51.21.11.60.70.71.1-1.6-2.30.30.0-0.72.0-0.6
Co content in liver3.33.87.62.72.12.42.02.4-2.31.32.12.01.82.11.61.61.8-2.1-2.81.40.90.32.40.5
Cu content in liver2.42.86.61.91.72.21.71.9-1.91.31.81.61.52.01.31.21.4-2.1-2.31.11.00.42.60.4
Fe content in liver0.20.30.80.20.40.30.40.2-0.30.70.40.50.50.50.50.60.5-0.5-0.10.60.80.90.30.8
K content in liver0.30.31.40.0-0.4-0.1-0.3-0.10.2-0.7-0.3-0.6-0.5-0.2-0.6-0.7-0.50.2-0.2-0.8-0.9-1.20.3-1.1
Mg content in liver0.60.61.6-0.3-0.7-0.4-0.6-0.50.5-1.0-0.6-0.8-0.8-0.6-0.9-0.9-0.70.60.1-1.0-1.0-1.3-0.2-1.1
Mn content in liver0.00.00.20.1-0.0-0.10.00.1-0.1-0.20.1-0.1-0.10.1-0.1-0.2-0.1-0.1-0.0-0.2-0.1-0.40.4-0.4
Na content in liver0.10.10.30.10.10.20.20.1-0.20.50.20.10.20.40.20.10.3-0.4-0.10.20.50.40.50.3
Rb content in liver1.01.23.6-0.4-0.9-0.4-1.0-0.50.6-1.5-0.8-1.0-1.1-0.7-1.3-1.4-1.20.7-0.1-1.5-1.6-1.90.1-1.9
Se content in liver0.20.31.20.3-0.00.2-0.10.2-0.1-0.50.0-0.3-0.30.1-0.5-0.4-0.4-0.1-0.5-0.6-0.7-1.10.8-1.1
Sr content in liver2.21.94.32.11.61.61.61.8-1.70.81.51.41.31.51.11.11.2-1.5-1.90.80.3-0.11.70.1
Zn content in liver0.70.72.71.30.51.20.50.9-0.8-0.40.50.20.10.6-0.2-0.30.2-0.6-1.6-0.5-0.8-1.51.2-1.3
Bone: minimum diameter0.51.01.6-1.3-1.2-0.9-1.0-1.01.0-0.9-1.0-1.0-1.1-0.7-1.2-1.0-1.10.60.7-1.2-0.8-0.9-0.2-1.1
Time in familiar zone, hab. session 10.10.10.40.50.30.50.20.4-0.40.20.30.20.30.30.20.00.3-0.3-0.60.0-0.0-0.10.3-0.1
Time in novel zone, hab. session 10.10.10.4-0.10.2-0.10.30.0-0.10.40.10.30.20.10.40.40.2-0.10.30.50.60.6-0.20.6
Total zone transitions, hab. session 10.10.10.6-0.5-0.1-0.1-0.2-0.30.30.1-0.2-0.10.0-0.30.00.00.00.30.30.10.40.4-0.80.5
Total locomotion distance, hab. session 10.10.20.9-0.7-0.4-0.4-0.5-0.60.5-0.1-0.5-0.4-0.2-0.5-0.2-0.3-0.30.60.5-0.20.10.2-0.90.2
Locomotion velocity, hab. session 10.30.51.5-1.0-0.7-0.7-0.8-0.90.8-0.4-0.8-0.6-0.5-0.9-0.4-0.5-0.50.90.9-0.3-0.00.2-1.20.1
Time in familiar zone, hab. session 20.20.20.9-0.5-0.5-0.8-0.4-0.60.6-0.1-0.6-0.4-0.3-0.5-0.4-0.1-0.30.50.9-0.3-0.30.1-1.00.1
Time in novel zone, hab. session 20.40.41.70.90.50.90.30.8-0.7-0.20.60.40.20.60.1-0.10.1-0.6-1.3-0.1-0.2-0.61.3-0.7
Total zone transitions, hab. session 20.50.62.8-0.50.40.10.3-0.10.00.90.20.30.60.00.80.80.60.00.51.01.61.6-0.81.7
Total locomotion distance, hab. session 20.40.52.1-0.80.0-0.3-0.0-0.40.30.6-0.2-0.10.3-0.30.50.30.40.40.80.71.31.3-1.31.4
Locomotion velocity, hab. session 20.40.62.0-1.0-0.1-0.4-0.2-0.60.50.5-0.4-0.30.2-0.50.40.20.30.51.00.61.31.3-1.41.4
Novel to familiar place preference ratio2.42.63.71.31.71.61.61.4-1.51.81.61.81.71.51.81.81.6-1.4-1.21.91.71.91.01.8
Novelty place preference2.22.33.41.31.61.61.41.4-1.41.71.51.71.61.41.71.71.5-1.4-1.21.81.61.81.01.7
Time in novel zone, NPP test2.32.53.21.41.71.71.51.5-1.51.71.61.71.61.51.71.71.5-1.5-1.41.81.51.71.31.6
Total zone transitions, NPP test0.30.41.6-0.70.20.20.1-0.20.10.60.00.10.4-0.10.60.40.40.20.50.81.21.2-0.81.3
Total locomotion distance, NPP test0.30.51.7-1.0-0.1-0.3-0.2-0.50.50.5-0.3-0.20.2-0.50.40.30.20.50.90.61.11.2-1.31.3
Locomotion velocity, NPP test0.40.52.1-1.00.0-0.2-0.1-0.50.40.6-0.3-0.10.3-0.40.50.40.30.50.90.71.21.3-1.41.5
Intraocular pressure0.10.10.3-0.3-0.3-0.5-0.3-0.40.4-0.4-0.4-0.4-0.5-0.4-0.4-0.3-0.50.40.4-0.3-0.1-0.1-0.1-0.3
Delta distance traveled before/after self-admin2.93.17.3-2.7-2.1-2.4-1.7-2.22.1-1.1-1.9-1.8-1.6-1.8-1.4-1.2-1.51.72.5-1.2-0.7-0.5-2.1-0.3
Delta ambulatory time before/after self-admin2.53.16.0-2.4-2.0-2.4-1.6-2.12.0-1.2-2.0-1.8-1.6-1.8-1.5-1.3-1.51.82.4-1.4-0.9-0.8-2.2-0.5
Parametrial fat weight5.112.017.9-2.4-3.5-3.0-3.5-3.03.1-4.1-3.4-3.2-3.5-3.3-3.9-3.8-3.53.22.0-4.1-4.2-4.2-2.7-4.0
Pavlov. Cond. lever latency0.30.31.60.4-0.20.2-0.30.2-0.1-0.7-0.0-0.0-0.4-0.0-0.5-0.4-0.50.0-0.9-0.6-1.3-1.00.7-1.2
Pavlov. Cond. magazine entry latency0.10.10.8-0.00.20.20.40.2-0.20.40.30.20.20.50.20.30.2-0.6-0.10.20.60.10.90.2
Pavlov. Cond. change in total contacts0.10.10.5-0.40.10.00.2-0.0-0.00.50.1-0.00.20.20.30.20.3-0.30.40.40.70.60.30.6
Pavlov. Cond. index score0.30.41.9-0.30.40.00.50.0-0.10.80.30.30.50.40.60.70.5-0.50.50.71.41.00.21.2
Pavlov. Cond. latency score0.30.41.7-0.20.40.10.50.0-0.10.80.30.30.50.40.60.60.5-0.40.50.71.31.00.01.1
Pavlov. Cond. lever contacts0.40.52.10.00.50.20.60.2-0.31.00.40.50.70.50.80.80.7-0.50.40.81.41.2-0.01.3
Pavlov. Cond. magazine entry number0.10.10.50.60.00.2-0.10.2-0.1-0.4-0.10.0-0.0-0.2-0.2-0.2-0.10.3-0.5-0.2-0.7-0.5-0.5-0.5
Pavlov. Cond. intertrial magazine entries0.60.71.2-0.9-0.9-1.1-0.9-0.90.9-0.9-0.8-0.9-0.9-1.0-0.7-0.9-0.81.00.9-0.6-0.5-0.4-0.7-0.5
Pavlov. Cond. lever-magazine prob. diff.0.30.41.9-0.40.30.00.5-0.0-0.10.80.30.30.50.40.60.60.5-0.50.50.71.41.00.21.2
Pavlov. Cond. response bias0.10.10.6-0.8-0.2-0.30.0-0.40.30.3-0.2-0.3-0.0-0.00.10.10.0-0.00.80.10.80.4-0.00.6
Pavlov. Cond. lever latency0.50.72.31.40.60.80.81.0-0.9-0.10.70.40.40.80.10.10.4-0.9-1.3-0.3-0.2-1.11.5-0.9
Pavlov. Cond. magazine entry latency0.20.21.0-0.8-0.3-0.5-0.3-0.40.40.3-0.2-0.1-0.1-0.20.10.1-0.10.10.90.30.41.0-0.30.7
Pavlov. Cond. change in total contacts0.20.41.4-0.9-0.2-0.5-0.4-0.60.50.3-0.4-0.1-0.1-0.50.20.2-0.10.51.00.50.41.2-1.01.0
Pavlov. Cond. index score0.40.61.8-1.3-0.6-0.8-0.7-0.90.80.1-0.7-0.4-0.4-0.7-0.1-0.0-0.40.71.30.20.21.1-1.20.8
Pavlov. Cond. latency score0.50.72.2-1.4-0.7-0.9-0.7-1.00.90.1-0.7-0.4-0.4-0.7-0.1-0.1-0.40.71.50.20.31.2-1.30.8
Pavlov. Cond. lever contacts0.60.93.3-1.5-0.6-0.8-0.8-1.11.00.2-0.8-0.4-0.3-0.9-0.00.0-0.41.01.50.40.31.4-1.81.1
Pavlov. Cond. magazine entry number0.20.31.90.80.10.40.20.4-0.3-0.60.1-0.1-0.10.0-0.3-0.4-0.00.0-0.9-0.6-0.8-1.40.2-1.0
Pavlov. Cond. intertrial magazine entries0.30.51.01.00.80.80.80.8-0.80.50.70.80.70.70.60.70.6-0.6-1.00.50.2-0.00.60.2
Pavlov. Cond. lever-magazine prob. diff.0.30.41.2-1.1-0.4-0.6-0.6-0.70.70.2-0.5-0.2-0.2-0.50.00.1-0.30.51.10.30.21.1-1.00.8
Pavlov. Cond. response bias0.30.52.4-0.9-0.1-0.3-0.3-0.50.40.6-0.30.10.1-0.40.40.40.10.41.00.70.61.5-1.11.3
Time in closed arm before self-admin1.31.72.31.21.41.11.31.4-1.41.31.41.21.41.51.31.31.4-1.5-1.11.21.31.11.31.0
Time in closed arm after self-admin1.01.02.81.61.21.20.81.3-1.30.41.21.10.91.20.70.50.8-1.2-1.40.40.1-0.21.7-0.3
Time in open arm before self-admin3.64.05.1-2.2-2.2-2.2-1.9-2.32.2-1.9-2.2-1.9-2.0-2.1-2.0-1.7-2.02.12.0-1.9-1.6-1.3-2.3-1.3
Time in open arm after self-admin0.40.51.9-1.1-0.8-0.9-0.5-0.90.9-0.1-0.8-0.6-0.4-0.8-0.3-0.2-0.40.80.9-0.10.20.6-1.40.5
Bone: periosteal estimation1.42.94.1-1.9-2.0-1.5-1.8-1.71.7-1.7-1.7-1.9-1.9-1.4-1.9-1.9-1.91.31.1-2.0-1.6-1.6-0.5-1.8
Bone: periosteal perimeter2.33.95.4-1.8-2.2-1.8-2.0-1.81.9-2.2-1.9-2.1-2.2-1.8-2.3-2.2-2.21.71.2-2.3-2.2-2.2-0.9-2.3
Bone: post-yield work0.71.11.6-1.2-1.1-1.1-1.1-1.11.1-0.9-1.1-1.2-1.1-1.0-1.0-1.1-1.01.01.0-1.0-0.6-0.7-0.9-0.8
Progressive ratio test 1 active lever presses7.99.712.3-3.1-3.2-3.3-3.4-3.43.4-3.1-3.3-3.3-3.2-3.5-3.0-3.0-3.23.53.1-2.8-2.7-2.2-3.3-2.1
Progressive ratio test 1 breakpoint8.19.912.5-3.1-3.2-3.3-3.4-3.43.4-3.2-3.4-3.3-3.3-3.5-3.1-3.0-3.23.53.1-2.8-2.8-2.2-3.3-2.1
Progressive ratio test 1 inactive lever presses2.94.25.1-1.9-2.1-1.9-2.2-2.12.2-2.2-2.2-2.2-2.2-2.1-2.2-2.1-2.32.11.7-2.0-2.0-1.8-1.5-1.8
Progressive ratio test 2 active lever presses2.52.93.6-1.9-1.9-1.7-1.9-1.91.8-1.7-1.8-1.7-1.7-1.8-1.7-1.6-1.71.71.5-1.6-1.7-1.4-1.7-1.2
Progressive ratio test 2 breakpoint2.62.93.8-2.0-1.9-1.8-1.9-1.91.9-1.7-1.8-1.7-1.7-1.8-1.7-1.6-1.71.71.6-1.6-1.6-1.3-1.7-1.1
Progressive ratio test 2 inactive lever presses1.72.73.6-1.9-1.8-1.6-1.9-1.81.8-1.7-1.8-1.6-1.8-1.6-1.8-1.7-1.81.61.5-1.7-1.6-1.3-1.0-1.4
Incentive Sensitization - Responses0.00.00.4-0.6-0.2-0.1-0.2-0.20.20.0-0.1-0.00.0-0.1-0.00.00.00.00.2-0.10.00.1-0.20.2
Incentive Sensitization - Breakpoint0.00.00.5-0.7-0.3-0.1-0.3-0.20.2-0.0-0.2-0.1-0.0-0.1-0.00.0-0.00.10.2-0.10.00.1-0.20.2
Sum of active levers in priming session hrs 5-60.10.10.50.0-0.1-0.40.10.0-0.00.20.10.10.1-0.00.30.30.10.00.20.50.30.70.00.6
Progressive ratio0.10.20.5-0.5-0.4-0.3-0.2-0.40.4-0.2-0.4-0.5-0.3-0.4-0.4-0.4-0.30.30.2-0.5-0.3-0.5-0.7-0.3
Food seeking constrained by brief footshock0.70.82.91.40.31.0-0.00.8-0.7-0.60.40.2-0.00.5-0.4-0.6-0.1-0.5-1.7-0.7-1.4-1.51.4-1.6
Seeking ratio, punishment vs. effort0.10.10.60.50.10.3-0.20.3-0.2-0.20.20.2-0.00.2-0.1-0.2-0.1-0.3-0.5-0.2-0.3-0.20.8-0.5
Retroperitoneal fat weight4.318.220.7-3.9-4.5-4.5-4.4-4.24.2-4.5-4.4-4.3-4.3-4.2-4.5-4.3-4.34.13.7-4.5-4.6-4.1-3.7-4.0
Reaction time number correct0.20.31.6-1.3-0.5-0.5-0.5-0.80.70.2-0.5-0.3-0.3-0.4-0.20.0-0.40.30.80.10.50.9-0.50.6
Reaction time mean minus median0.51.43.6-1.6-1.2-1.6-1.0-1.51.4-0.6-1.3-1.1-1.0-1.3-0.9-0.7-0.91.21.9-0.6-0.30.1-1.80.0
Reaction time mean minus median AUC0.71.83.9-1.7-1.4-1.8-1.2-1.61.6-0.8-1.5-1.3-1.2-1.4-1.1-0.9-1.11.42.0-0.8-0.5-0.1-2.0-0.2
Reaction time num false alarms0.60.81.7-1.2-1.0-1.2-0.9-1.11.1-0.6-1.0-0.8-0.8-1.1-0.7-0.6-0.81.11.3-0.5-0.5-0.1-1.2-0.0
Reaction time num false alarms AUC0.81.32.8-1.6-1.2-1.5-1.2-1.41.4-0.7-1.2-1.0-1.0-1.4-0.8-0.8-0.91.41.7-0.6-0.50.0-1.70.0
Reaction time trials correct on left0.20.31.6-1.3-0.5-0.5-0.5-0.80.70.2-0.5-0.3-0.3-0.4-0.20.0-0.40.30.80.10.50.9-0.50.6
Reaction time trials on left0.20.41.9-1.4-0.6-0.6-0.6-0.90.80.2-0.6-0.3-0.4-0.4-0.2-0.0-0.50.40.80.00.50.9-0.60.6
Reaction time mean0.50.71.9-0.2-0.7-0.6-0.6-0.50.6-1.1-0.7-0.7-0.8-0.7-1.0-0.9-0.80.80.3-1.1-1.3-1.4-0.5-1.3
Reaction time mean AUC0.40.61.7-0.2-0.6-0.6-0.5-0.50.5-1.1-0.7-0.7-0.8-0.7-0.9-0.8-0.70.70.4-1.0-1.2-1.3-0.5-1.2
Median of all reaction times0.50.72.90.3-0.4-0.2-0.3-0.10.2-1.1-0.4-0.6-0.7-0.5-0.9-0.9-0.70.5-0.2-1.1-1.5-1.7-0.1-1.5
Reaction time omissions2.33.46.7-2.2-2.0-2.0-1.9-2.32.2-1.4-2.1-1.8-1.8-2.1-1.6-1.5-1.82.12.1-1.4-1.1-0.6-2.6-0.6
Reaction time false alarm rate0.40.51.3-0.7-0.7-1.0-0.7-0.80.7-0.7-0.8-0.7-0.6-0.9-0.5-0.6-0.61.01.0-0.4-0.6-0.3-1.1-0.2
Reaction time premature initiation rate0.40.52.5-0.3-0.5-0.9-0.5-0.70.7-0.6-0.8-0.6-0.4-0.9-0.5-0.5-0.40.90.9-0.6-0.3-0.4-1.6-0.2
Reaction time premature initiations0.40.72.7-1.0-0.8-1.1-0.8-1.11.0-0.5-1.0-0.7-0.6-1.0-0.6-0.5-0.61.01.2-0.6-0.1-0.0-1.60.0
Std. dev. reaction times1.22.14.3-1.7-1.5-1.9-1.3-1.71.7-1.1-1.6-1.4-1.3-1.6-1.3-1.1-1.31.62.1-1.2-0.8-0.6-2.1-0.5
Reaction time trials completed0.20.41.9-1.4-0.6-0.6-0.6-0.90.80.2-0.6-0.3-0.4-0.4-0.2-0.0-0.50.40.80.00.50.9-0.60.6
Reaction time trials AUC0.30.52.2-1.5-0.7-0.7-0.7-1.00.90.1-0.7-0.5-0.5-0.6-0.3-0.1-0.60.51.0-0.00.40.8-0.70.5
Run reversals in cocaine runway, females0.70.71.3-0.4-0.9-0.6-0.9-0.60.7-0.9-0.7-0.9-0.9-0.8-0.9-1.1-0.80.80.2-1.0-1.2-1.0-0.5-1.1
Run reversals in cocaine runway, males1.31.32.8-1.4-1.2-1.3-1.3-1.41.3-0.9-1.3-1.2-1.1-1.2-1.1-1.1-1.11.21.7-1.0-0.6-0.4-1.3-0.5
Latency to leave start box in cocaine runway0.60.71.11.10.80.80.70.9-0.90.80.80.70.90.80.80.70.9-0.8-1.00.70.80.70.30.6
Latency to leave start box in cocaine runway, F0.50.60.90.90.80.70.80.7-0.80.90.80.70.90.80.80.90.9-0.9-0.60.70.90.80.30.7
Latency to leave start box in cocaine runway, M0.00.00.20.20.10.1-0.10.2-0.20.10.20.00.30.10.20.00.2-0.1-0.40.20.30.4-0.20.2
Std. dev. time between licks in bursts1.11.52.4-1.0-1.2-1.1-1.2-1.31.3-1.1-1.4-1.3-1.2-1.3-1.3-1.3-1.11.31.2-1.3-1.1-1.0-1.6-0.9
Total sessions with >9 infusions1.21.42.5-1.5-1.2-1.5-1.1-1.41.4-1.0-1.3-1.3-1.1-1.3-1.0-0.9-1.11.31.5-0.9-0.7-0.7-1.6-0.4
Short access day 1 total inactive lever presses2.83.65.2-1.7-1.9-2.3-1.9-1.91.9-2.1-2.0-1.9-2.0-1.9-2.0-2.0-1.91.92.2-1.9-1.5-1.8-1.5-1.6
Short access day 10 total inactive lever presses0.51.22.3-1.3-1.2-1.4-1.3-1.31.3-0.9-1.2-1.2-1.1-1.3-0.9-1.0-1.11.41.5-0.7-0.5-0.1-1.4-0.3
Short access day 1 total infusions2.12.83.7-1.3-1.5-1.7-1.7-1.61.6-1.9-1.7-1.8-1.7-1.8-1.6-1.8-1.71.91.6-1.6-1.7-1.6-1.5-1.5
Short access day 10 total infusions0.70.91.9-0.9-0.8-1.1-1.0-1.11.1-0.9-1.1-1.2-0.9-1.1-0.9-0.8-0.91.21.1-0.8-0.7-0.6-1.4-0.5
Short access total infusions1.62.02.5-1.4-1.4-1.4-1.4-1.51.5-1.5-1.5-1.6-1.4-1.6-1.4-1.4-1.41.61.4-1.3-1.2-1.3-1.6-1.0
Short access day 1 locomotion0.50.60.9-0.9-0.8-0.8-0.8-0.80.8-0.8-0.8-0.9-0.9-0.9-0.7-0.8-0.80.90.6-0.6-0.6-0.5-0.5-0.5
Short access day 10 total locomotion0.20.31.0-0.7-0.5-0.8-0.5-0.70.7-0.4-0.6-0.6-0.4-0.6-0.4-0.3-0.40.60.8-0.40.1-0.3-1.00.0
Short access total locomotion0.70.91.9-1.2-0.9-1.0-0.9-1.11.1-0.8-1.1-1.0-0.8-1.0-0.8-0.7-0.81.01.1-0.8-0.3-0.5-1.4-0.3
One hour access (0.3 mA shock)1.21.42.5-1.6-1.3-1.4-1.2-1.41.4-1.0-1.3-1.4-1.2-1.3-1.0-0.9-1.21.31.3-0.8-0.7-0.4-1.2-0.4
Compulsive drug intake0.10.10.6-0.8-0.4-0.6-0.3-0.50.5-0.1-0.4-0.3-0.4-0.3-0.3-0.2-0.30.20.7-0.20.10.1-0.1-0.0
One hour access (shock baseline)0.30.50.8-0.6-0.7-0.5-0.8-0.60.7-0.9-0.7-0.8-0.7-0.7-0.7-0.7-0.70.70.3-0.7-0.9-0.8-0.5-0.7
Social response proportion0.20.21.10.3-0.4-0.1-0.10.00.0-0.7-0.1-0.2-0.4-0.1-0.5-0.5-0.30.0-0.3-0.7-0.4-1.00.6-1.0
Social responses0.60.71.3-0.5-0.9-0.7-0.7-0.60.6-1.2-0.7-0.9-0.8-0.9-0.9-1.1-0.81.00.4-1.0-0.7-1.1-0.6-1.1
Social time2.22.95.9-0.7-1.6-1.5-1.5-1.21.3-2.3-1.6-1.7-1.7-1.7-1.8-2.0-1.61.80.9-2.0-2.1-2.4-1.4-2.2
Soleus weight0.61.82.91.71.61.71.51.5-1.51.31.41.41.41.51.21.31.3-1.5-1.61.00.90.51.20.6
Bone: stiffness3.25.28.8-3.0-2.6-2.5-2.5-2.62.6-1.9-2.4-2.4-2.4-2.3-2.3-2.1-2.42.22.4-2.1-1.8-1.2-1.9-1.4
Tibialis anterior weight0.41.22.9-1.5-1.1-1.2-1.2-1.31.3-0.7-1.2-1.0-1.0-1.3-0.9-0.7-1.01.31.4-0.7-0.8-0.2-1.7-0.2
Time to tail flick, vehicle, before self-admin0.80.83.10.3-0.50.1-0.8-0.10.2-1.3-0.4-0.7-0.8-0.7-0.8-1.2-0.80.8-0.7-0.9-1.8-1.60.1-1.6
Time to tail flick, vehicle, after self-admin0.20.20.80.90.50.9-0.00.5-0.50.00.40.30.20.30.2-0.10.1-0.2-0.90.2-0.3-0.10.7-0.3
Time to tail flick, test, before self-admin4.24.37.32.32.22.72.12.3-2.31.92.22.22.02.31.81.81.9-2.4-2.61.61.51.22.71.0
Time to tail flick, test, after self-admin0.30.30.8-0.9-0.7-0.7-0.7-0.80.7-0.3-0.7-0.4-0.5-0.4-0.6-0.4-0.50.30.7-0.6-0.2-0.0-0.6-0.2
Delta time to tail flick, vehicle, before/after SA0.70.71.70.60.80.60.70.6-0.61.20.70.80.90.80.91.00.9-0.9-0.10.91.11.30.31.1
Delta time to tail flick, test, before/after SA4.44.56.3-2.1-2.2-2.5-2.2-2.22.2-2.2-2.2-2.2-2.1-2.1-2.2-2.1-2.12.02.2-2.2-1.9-1.8-2.0-1.7
Tibia length3.28.911.4-2.8-3.2-2.8-3.0-2.92.9-3.2-3.0-3.4-3.1-3.0-3.2-3.3-3.03.02.3-3.2-2.8-2.9-2.5-2.8
Ambulatory time before self-admin0.81.22.81.41.11.01.11.3-1.30.71.31.11.01.21.00.81.0-1.2-1.10.90.70.51.70.4
Ambulatory time after self-admin1.11.33.1-0.9-1.3-1.8-1.0-1.01.0-1.3-1.1-1.1-1.1-1.0-1.1-1.2-1.01.01.2-1.2-1.2-1.3-0.8-1.0
Bone: tissue strength0.00.00.1-0.1-0.10.1-0.00.0-0.0-0.1-0.0-0.2-0.00.1-0.1-0.2-0.0-0.1-0.1-0.20.1-0.30.1-0.2
Total heroin consumption0.10.10.60.40.3-0.00.20.2-0.20.30.3-0.10.2-0.00.50.30.20.10.10.60.30.80.00.6
Bone: trabecular number2.13.44.4-2.1-2.0-1.9-2.1-2.02.0-1.9-1.9-2.0-2.0-1.8-1.9-2.0-2.01.81.7-1.9-1.4-1.3-1.3-1.6
Bone: trabecular spacing1.31.72.81.31.41.01.61.2-1.21.41.21.51.51.01.51.71.5-1.0-0.81.51.21.30.21.6
Bone: trabecular thickness0.60.82.3-0.6-0.8-0.5-0.9-0.50.5-1.1-0.6-0.9-1.0-0.5-1.0-1.2-1.00.40.1-1.2-1.0-1.40.5-1.5
Bone: trabecular tissue density2.63.96.11.31.91.81.91.6-1.72.41.92.12.01.82.22.32.0-1.8-1.22.42.22.51.32.5
Water consumed over 24 hours0.20.20.5-0.4-0.4-0.2-0.4-0.30.4-0.6-0.4-0.5-0.5-0.5-0.5-0.5-0.50.50.3-0.5-0.6-0.7-0.5-0.6
Number of responses in last shaping day2.52.73.8-1.2-1.5-1.6-1.7-1.51.6-1.9-1.6-2.0-1.8-1.8-1.6-1.8-1.71.91.4-1.5-1.7-1.7-1.3-1.5