Hub : Genes

LOC134481246

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression LOC134481246 0.06 0.04 6.8e-03 0.03 0.04 0.03 0.03 1.8e-02 1.3e-02 1.6e-02 2.0e-02
2 Brain gene expression LOC134481246 0.15 0.08 1.7e-11 0.14 0.12 0.13 0.13 9.6e-13 2.6e-11 2.6e-12 4.5e-12
3 NAcc gene expression LOC134481246 0.24 0.11 0.0e+00 0.2 0.21 0.22 0.22 3.1e-29 9.3e-32 1.1e-32 2.0e-33
4 pVTA gene expression LOC134481246 0.03 0.02 8.1e-03 0.01 0.02 0 0.01 2.4e-02 1.2e-02 1.6e-01 3.1e-02
5 PL gene expression LOC134481246 0.13 0.07 5.2e-10 0.09 0.09 0.09 0.09 3.4e-10 7.0e-10 7.5e-10 3.6e-10
6 RMTg gene expression LOC134481246 0.33 0.16 9.1e-04 0.12 0.11 0.13 0.1 4.0e-04 7.7e-04 2.5e-04 1.4e-03
7 BLA gene expression LOC134481246 0.05 0.03 8.5e-03 0.02 0.02 0.02 0.02 4.5e-02 2.7e-02 2.3e-02 4.3e-02
8 IL gene expression LOC134481246 0.36 0.17 6.0e-03 0.01 0.05 0.03 0.04 1.6e-01 2.2e-02 6.5e-02 4.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.52.76.8-2.62.1-2.0-2.00.90.41.00.3
Area under the delay curve0.50.81.20.9-1.11.00.00.90.30.9-1.1
BMI with tail1.24.39.0-3.01.7-1.6-3.02.31.32.0-0.0
BMI without tail1.89.616.0-4.03.1-2.9-3.93.22.53.0-1.3
Body weight11.550.581.6-9.07.2-7.1-8.67.45.96.9-2.9
Weight adjusted by age0.10.41.2-1.11.0-0.7-0.70.10.00.20.4
Bone surface2.24.49.0-3.02.3-2.2-2.71.81.21.9-0.4
Bone volume0.81.54.3-2.11.3-1.3-1.70.80.20.80.5
Breakpoint value in progressive ratio session0.30.51.1-0.10.0-0.0-0.40.90.90.9-1.0
Number of licking bursts0.20.51.3-1.11.2-1.1-0.60.20.50.3-0.0
Context. condit. distance diff. score4.04.96.3-2.02.2-2.3-1.92.32.52.2-2.2
Locomotion velocity, session 10.30.30.90.9-0.60.70.8-0.4-0.2-0.3-0.2
Locomotion distance, session 11.52.03.71.9-1.21.31.9-1.4-0.9-1.50.3
Locomotion velocity, session 20.10.20.40.6-0.50.50.5-0.2-0.1-0.2-0.2
Locomotion distance, session 21.52.05.32.1-0.90.92.3-1.5-0.6-1.5-0.4
Locomotion velocity, session 30.50.51.1-0.50.5-0.5-0.60.81.10.8-0.7
Locomotion distance, session 30.10.10.20.10.3-0.40.4-0.40.2-0.4-0.0
Stereotopy head waving bouts, day 31.11.33.1-1.81.6-1.4-1.40.70.30.80.1
Stereotopy head waving duration, day 30.30.41.4-0.0-0.30.5-0.1-0.5-1.2-0.41.1
Locomotion velocity, session 70.80.81.50.8-1.21.0-0.21.00.41.0-1.2
Locomotion distance, session 70.40.51.80.9-0.40.40.50.40.50.4-1.3
Stereotopy head waving bouts, day 70.20.20.60.7-0.40.20.7-0.4-0.1-0.4-0.3
Stereotopy head waving duration, day 70.20.20.40.7-0.60.50.5-0.3-0.2-0.2-0.2
Locomotion velocity, session 80.20.20.4-0.30.1-0.2-0.40.60.40.6-0.6
Locomotion distance, session 81.01.42.1-0.81.1-1.2-0.81.21.41.2-1.4
Degree of sensitization distance0.60.61.51.2-1.11.10.8-0.2-0.5-0.2-0.4
Degree of sensitization stereotypy0.20.20.40.6-0.60.40.6-0.20.1-0.2-0.3
Conditioned locomotion0.20.20.80.0-0.1-0.00.2-0.6-0.5-0.70.9
Cocaine response after cond. corrected0.60.82.2-1.0-0.50.5-1.50.5-0.70.61.4
Cocaine response after cond. not corrected0.40.62.0-0.9-0.30.4-1.40.8-0.20.90.6
Cocaine response before conditioning0.50.62.80.30.5-0.50.30.51.10.5-1.7
Saline control response2.33.27.4-1.62.6-2.7-0.70.91.90.9-1.6
Bone: connectivity density3.55.610.5-3.22.9-2.8-2.71.91.42.0-0.8
Bone: cortical apparent density0.20.30.80.2-0.90.6-0.30.60.20.5-0.2
Bone: cortical area2.54.16.9-1.51.3-1.3-1.82.42.62.4-2.2
Bone: cortical porosity0.00.10.10.00.4-0.30.2-0.10.1-0.1-0.3
Bone: cortical porosity0.20.20.60.6-0.10.20.8-0.4-0.0-0.3-0.5
Bone: cortical thickness2.54.16.0-1.81.4-1.4-2.12.42.42.4-1.9
Bone: cortical thickness2.73.35.7-1.61.5-1.4-1.72.02.42.0-1.8
Bone: cortical tissue density0.10.20.90.3-0.90.7-0.20.40.10.3-0.0
Condit. Reinf. active minus inactive responses0.30.40.80.8-0.90.90.5-0.2-0.4-0.30.1
Condit. Reinf. active-inactive response ratio0.10.10.40.3-0.60.6-0.10.2-0.20.2-0.0
Condit. Reinf. active responses0.30.41.21.1-0.40.51.0-0.30.2-0.3-0.7
Condit. Reinf. inactive responses0.70.92.51.5-0.40.41.6-0.60.4-0.6-1.1
Incentive salience index mean0.30.41.01.0-0.70.60.9-0.3-0.1-0.4-0.4
Condit. Reinf. lever presses0.40.51.41.2-0.70.51.1-0.30.1-0.4-0.8
Condit. Reinf. active minus inactive responses1.72.65.0-0.91.1-1.2-1.01.82.21.8-2.2
Condit. Reinf. active-inactive response ratio1.21.94.2-0.50.5-0.5-0.91.72.11.7-1.9
Condit. Reinf. active responses1.82.65.7-0.81.3-1.4-0.81.72.21.7-2.4
Condit. Reinf. inactive responses0.20.30.8-0.30.8-0.90.00.20.40.2-0.7
Condit. Reinf. lever presses0.10.10.60.3-0.1-0.10.30.20.50.2-0.8
Condit. Reinf. lever reinforcers received1.31.85.3-0.30.8-1.0-0.41.31.91.3-2.3
Conditioned reinforcement - actives1.14.26.2-2.12.5-2.4-1.71.82.11.9-1.7
Conditioned reinforcement - inactives0.10.30.9-0.51.0-0.90.1-0.30.0-0.20.1
Conditioned locomotion2.63.95.4-1.92.2-2.3-1.61.92.21.9-1.8
Patch foraging indifference point 0 sec0.20.61.30.2-0.1-0.10.7-1.1-0.9-1.11.0
Patch foraging indifference point AUC0.51.22.2-1.41.5-1.4-1.00.60.90.8-0.5
Delay disc. indifference point, 0s delay2.02.35.3-1.1-0.30.4-2.32.31.02.3-0.5
Delay disc. indifference point, 16s delay0.20.30.80.6-0.50.40.30.40.20.4-0.9
Delay disc. indifference point, 2s delay1.21.33.71.3-1.91.8-0.00.80.00.8-0.6
Delay disc. indifference point, 24s delay0.20.40.90.9-0.90.90.5-0.0-0.3-0.0-0.3
Delay disc. indifference point, 4s delay0.50.61.50.6-1.21.2-0.30.80.10.7-0.4
Delay disc. indifference point, 8s delay0.20.41.20.8-0.50.40.50.40.50.4-1.1
Indifference point function ln k0.10.30.70.40.4-0.60.9-0.30.2-0.5-0.5
Indifference point function log k0.10.30.70.40.4-0.60.9-0.30.2-0.5-0.5
Patch foraging total patch changes 0 sec0.30.91.90.20.0-0.20.9-1.4-1.1-1.41.2
Patch foraging total patch changes 12 sec0.20.30.6-0.80.4-0.4-0.5-0.5-0.3-0.10.7
Patch foraging total patch changes 18 sec0.30.61.6-0.40.5-0.70.2-1.0-0.9-1.01.3
Patch foraging total patch changes 24 sec0.10.51.40.20.7-0.60.8-1.2-0.2-0.80.0
Patch foraging total patch changes 6 sec0.20.40.8-0.60.6-0.70.1-0.7-0.6-0.70.9
Patch foraging time to switch 0 sec0.72.87.40.6-2.62.7-0.70.3-1.7-0.02.2
Patch foraging water rate 0 sec0.83.08.7-1.42.8-2.9-0.10.11.60.3-1.6
Patch foraging water rate 12 sec0.20.92.3-0.21.1-1.20.30.41.20.3-1.5
Patch foraging water rate 18 sec0.40.83.80.60.3-0.50.70.21.20.4-1.9
Patch foraging water rate 24 sec2.13.06.4-1.52.3-2.5-0.71.11.91.0-1.8
Patch foraging water rate 6 sec0.60.82.1-0.51.3-1.50.00.31.00.3-1.1
Seeking ratio, delayed vs. immediate footshock2.53.55.61.4-1.41.41.5-2.2-2.4-2.22.2
Distance traveled before self-admin0.10.31.00.8-1.00.90.30.0-0.3-0.0-0.2
Distance traveled after self-admin0.10.20.60.7-0.00.00.8-0.3-0.2-0.3-0.8
Extensor digitorum longus weight4.216.821.5-4.54.6-4.5-4.03.94.13.9-3.0
Bone: elastic displacement0.20.30.6-0.30.7-0.6-0.20.40.70.4-0.8
Bone: elastic work3.24.25.7-2.12.4-2.3-1.71.82.31.8-1.7
Bone: endosteal estimation0.20.62.0-0.81.4-1.3-0.0-0.20.3-0.2-0.2
Bone: endosteal perimeter0.40.91.9-0.41.3-1.10.00.41.20.4-1.4
Epididymis fat weight0.00.00.10.2-0.00.10.20.20.20.1-0.2
Delta time in closed arm before/after self-admin0.70.71.4-0.50.5-0.5-0.71.00.61.2-1.2
Delta time in open arm before/after self-admin3.13.75.22.3-2.22.12.1-2.0-0.9-2.11.2
Diff in mean of infusions in LGA sessions0.10.10.3-0.20.4-0.5-0.00.20.40.2-0.5
Delay discount exponential model param0.70.91.7-1.21.3-1.2-0.3-0.7-0.3-0.71.2
Extinction: sum of active levers before priming0.10.20.50.7-0.70.60.5-0.2-0.1-0.2-0.3
Active lever presses in extinction session 60.00.00.1-0.10.2-0.30.10.00.2-0.1-0.1
Bone: final force1.83.04.1-1.91.7-1.6-1.71.82.01.7-1.3
Bone: final moment1.32.23.0-1.61.5-1.4-1.41.51.71.5-1.1
Food consumed during 24 hour testing period0.20.51.4-0.70.6-0.7-0.2-0.7-0.5-0.61.2
Glucose1.32.16.01.8-2.12.41.2-0.4-0.9-0.70.4
Heart weight0.61.02.6-0.21.0-1.10.00.91.40.6-1.6
Delay discount hyperbolic model param0.60.81.6-1.11.3-1.2-0.2-0.8-0.3-0.81.1
Intermittent access intake day 1-15 change0.10.72.2-1.11.5-1.3-0.40.00.30.00.0
Intermittent access intake escalation0.10.72.0-1.11.4-1.3-0.50.10.30.10.1
Intermittent access intake escalation 20.20.30.60.10.2-0.10.5-0.8-0.6-0.80.6
Intermitt. access day 1 inactive lever presses0.00.20.6-0.40.8-0.50.0-0.5-0.3-0.30.4
Intermitt. access day 15 inactive lever presses0.20.93.5-0.3-0.80.8-0.5-0.3-1.3-0.41.9
Intermitt. access escalation Index0.00.10.30.5-0.20.30.5-0.00.20.0-0.6
Intermittent access day 1 total infusions0.10.40.90.9-0.40.50.7-0.10.4-0.1-0.9
Intermittent access day 15 total infusions0.10.20.80.10.6-0.50.30.10.70.1-0.9
Intermittent access terminal intake (last 3 days)0.00.10.30.20.2-0.00.3-0.10.3-0.0-0.5
Intermittent access total infusions0.20.20.70.3-0.20.3-0.00.40.60.4-0.8
Intermittent access day 1 locomotion0.20.30.80.9-0.70.60.50.10.30.1-0.8
Intermittent access day 15 total locomotion0.20.82.1-0.21.1-1.00.10.41.20.4-1.4
Intermittent access total locomotion0.20.31.20.5-0.10.10.30.20.70.2-1.1
Intermittent access standard deviation0.10.52.2-0.70.00.1-0.6-0.3-0.9-0.41.5
Left kidney weight4.233.957.6-7.66.9-7.0-6.55.34.54.8-2.0
Right kidney weight4.028.048.7-7.06.0-6.1-6.25.14.04.5-1.6
Cocaine induced anxiety0.10.20.50.3-0.40.4-0.10.50.50.4-0.7
Post-drug Anxiety1.71.96.51.3-2.62.6-0.10.5-0.40.40.1
Baseline Anxiety1.22.06.31.1-2.52.50.0-0.2-1.3-0.11.1
Tail length5.730.443.2-6.66.1-6.1-5.95.35.05.1-3.3
Length with tail15.568.999.2-10.09.0-9.0-9.18.37.58.0-4.5
Length without tail5.529.048.8-7.05.9-5.9-6.25.34.45.0-1.9
Times rat made contact with spout0.50.61.0-0.90.9-0.8-0.70.71.00.7-0.5
Lifetime Intake0.10.20.50.5-0.60.70.10.10.20.2-0.4
Liver weight, left1.62.76.8-2.42.6-2.6-1.2-0.2-0.1-0.31.0
Liver weight, right2.03.57.4-2.72.4-2.1-2.21.41.11.4-0.1
Locomotor activity2.84.39.8-1.12.3-2.3-0.51.42.91.6-3.1
Locomotor testing distance0.40.92.4-0.51.4-1.60.20.11.10.1-1.2
Locomotor testing rearing0.10.51.20.30.2-0.30.9-1.0-0.7-1.10.6
Locomotion in novel chamber1.11.42.9-1.01.6-1.7-0.60.81.30.8-1.2
Locomotion in novel chamber post-restriction1.03.15.0-1.22.1-2.1-0.81.42.21.5-2.2
Fecal boli incidents, locomotor time 10.92.32.8-1.41.6-1.6-1.11.41.61.5-1.7
Change in fecal boli incidents, locomotor task0.20.30.90.1-0.60.6-0.2-0.2-0.5-0.41.0
Time >=10cm from walls, locomotor time 10.81.03.01.2-1.71.70.4-0.0-0.7-0.10.2
Bouts of movement, locomotor time 11.21.62.5-1.41.6-1.5-1.01.11.21.2-1.1
Total resting periods, locomotor time 11.41.62.3-1.31.5-1.4-1.01.01.21.3-1.2
Rest time, locomotor task time 10.91.52.2-1.51.3-1.2-1.41.11.01.3-0.8
Distance moved, locomotor task time 10.10.41.01.0-0.70.70.9-0.20.0-0.5-0.3
Vertical activity count, locomotor time 10.00.21.00.20.4-0.40.50.20.5-0.0-1.0
Time >=10cm from walls, locomotor time 20.41.02.5-0.9-0.00.1-1.61.60.41.5-0.3
Bouts of movement, locomotor time 20.41.32.0-1.21.4-1.4-0.91.01.21.1-1.0
Total resting periods, locomotor time 20.31.11.8-1.21.3-1.3-0.90.90.91.0-0.7
Rest time, locomotor task time 20.10.10.30.5-0.50.50.4-0.4-0.1-0.20.1
Distance moved, locomotor task time 20.10.10.2-0.30.5-0.4-0.10.1-0.1-0.2-0.0
Vertical activity count, locomotor time 20.61.53.5-1.51.9-1.8-0.90.90.60.6-0.8
Light reinforcement 10.31.32.91.7-1.71.60.8-0.10.30.2-1.0
Light reinforcement 20.20.30.50.6-0.60.70.5-0.6-0.6-0.50.5
Bone: marrow area0.20.51.9-0.81.4-1.20.0-0.30.3-0.3-0.1
Bone: maximum diameter1.12.33.0-1.61.5-1.5-1.41.51.71.5-1.3
Bone: maximum force1.42.74.2-1.71.8-1.6-1.41.52.11.5-1.5
Bone: maximum moment1.12.13.2-1.51.7-1.5-1.21.31.81.3-1.3
Mean time between licks in bursts0.52.83.91.7-1.21.31.9-2.0-1.7-2.01.3
Mean num. licks in bursts0.00.10.20.3-0.50.50.2-0.1-0.1-0.10.1
Cd content in liver0.70.82.41.10.2-0.41.2-0.20.9-0.2-1.5
Co content in liver0.81.01.9-0.81.1-1.30.0-0.9-0.8-1.01.4
Cu content in liver0.30.30.70.8-0.60.20.8-0.6-0.1-0.70.2
Fe content in liver0.60.82.3-0.10.6-0.6-0.10.71.50.7-1.4
K content in liver0.30.30.7-0.4-0.10.1-0.80.70.40.7-0.1
Mg content in liver0.70.81.5-1.20.7-0.9-1.20.80.70.8-0.0
Mn content in liver0.30.30.50.3-0.40.40.5-0.7-0.5-0.70.7
Na content in liver1.61.82.7-1.31.0-1.0-1.61.61.41.6-1.0
Rb content in liver2.42.85.02.1-2.22.21.7-1.3-1.2-1.30.6
Se content in liver1.82.14.3-1.30.1-0.3-2.12.11.32.0-0.7
Sr content in liver0.30.30.6-0.80.7-0.7-0.4-0.1-0.2-0.10.6
Zn content in liver2.42.86.3-2.42.3-2.5-1.70.90.80.90.1
Bone: minimum diameter0.10.20.50.6-0.30.30.7-0.30.2-0.3-0.4
Time in familiar zone, hab. session 10.80.92.90.1-0.60.70.1-0.9-1.3-0.91.7
Time in novel zone, hab. session 10.70.81.2-0.70.6-0.7-0.81.00.91.0-1.1
Total zone transitions, hab. session 10.81.23.21.8-1.00.91.7-0.8-0.2-0.8-0.7
Total locomotion distance, hab. session 10.30.51.31.1-0.91.00.7-0.1-0.0-0.1-0.4
Locomotion velocity, hab. session 10.91.23.21.8-1.41.51.3-0.5-0.1-0.6-0.4
Time in familiar zone, hab. session 20.20.30.8-0.2-0.50.6-0.50.0-0.70.00.9
Time in novel zone, hab. session 20.30.30.80.7-0.1-0.10.9-0.30.3-0.3-0.8
Total zone transitions, hab. session 20.30.30.8-0.20.6-0.90.10.30.80.2-0.8
Total locomotion distance, hab. session 20.10.20.40.6-0.00.10.7-0.20.3-0.3-0.4
Locomotion velocity, hab. session 20.10.10.40.60.00.00.6-0.20.3-0.2-0.4
Novel to familiar place preference ratio0.10.10.30.2-0.1-0.10.10.20.50.2-0.6
Novelty place preference0.10.10.20.5-0.40.20.4-0.10.3-0.1-0.4
Time in novel zone, NPP test0.00.00.10.3-0.30.10.20.00.20.0-0.3
Total zone transitions, NPP test0.00.10.20.30.2-0.30.4-0.20.1-0.2-0.4
Total locomotion distance, NPP test0.10.10.40.6-0.10.30.30.10.40.1-0.6
Locomotion velocity, NPP test0.20.31.10.50.2-0.10.50.20.70.2-1.0
Intraocular pressure1.21.93.1-1.41.7-1.8-1.11.11.41.2-1.2
Delta distance traveled before/after self-admin0.30.30.60.00.8-0.80.6-0.6-0.1-0.6-0.1
Delta ambulatory time before/after self-admin0.40.71.50.8-0.00.11.2-1.2-0.8-1.20.4
Parametrial fat weight0.20.62.0-0.9-0.30.4-1.40.5-0.30.60.9
Pavlov. Cond. lever latency1.01.32.8-1.71.6-1.4-1.30.70.70.8-0.0
Pavlov. Cond. magazine entry latency1.21.53.1-0.60.9-0.8-0.71.31.81.4-1.7
Pavlov. Cond. change in total contacts0.50.61.40.7-1.21.0-0.00.70.40.6-0.7
Pavlov. Cond. index score0.20.20.60.2-0.20.2-0.10.60.60.6-0.8
Pavlov. Cond. latency score0.20.30.70.5-0.50.40.10.50.60.5-0.8
Pavlov. Cond. lever contacts0.91.12.51.5-1.61.41.0-0.6-0.6-0.60.1
Pavlov. Cond. magazine entry number1.01.33.00.4-0.80.70.6-1.2-1.6-1.21.7
Pavlov. Cond. intertrial magazine entries2.22.64.01.7-0.90.92.0-2.0-1.8-2.01.1
Pavlov. Cond. lever-magazine prob. diff.0.20.20.40.1-0.20.2-0.30.60.60.6-0.7
Pavlov. Cond. response bias0.60.71.8-0.20.4-0.4-0.41.01.31.0-1.3
Pavlov. Cond. lever latency0.30.51.1-1.10.9-0.7-0.80.1-0.20.20.7
Pavlov. Cond. magazine entry latency1.21.63.92.0-2.01.81.3-0.40.0-0.4-0.6
Pavlov. Cond. change in total contacts0.20.61.51.2-0.50.41.2-0.30.3-0.4-1.0
Pavlov. Cond. index score0.91.53.71.9-1.51.21.6-0.60.0-0.6-0.8
Pavlov. Cond. latency score0.81.23.21.8-1.51.21.4-0.5-0.0-0.5-0.7
Pavlov. Cond. lever contacts0.40.71.51.2-1.10.90.9-0.10.4-0.1-0.9
Pavlov. Cond. magazine entry number1.51.94.7-2.21.8-1.6-1.80.80.20.80.5
Pavlov. Cond. intertrial magazine entries0.20.51.2-0.61.1-0.9-0.30.40.60.4-0.7
Pavlov. Cond. lever-magazine prob. diff.1.01.53.92.0-1.61.31.7-0.60.1-0.6-0.8
Pavlov. Cond. response bias0.91.33.21.8-1.41.21.4-0.30.4-0.3-1.1
Time in closed arm before self-admin0.91.63.8-1.31.9-1.9-0.60.71.10.7-1.0
Time in closed arm after self-admin2.12.44.3-1.32.1-2.1-0.81.11.41.3-1.8
Time in open arm before self-admin0.20.30.8-0.00.0-0.0-0.30.80.30.7-0.9
Time in open arm after self-admin1.41.53.21.4-1.81.61.1-1.0-0.7-1.10.8
Bone: periosteal estimation0.92.23.5-1.41.7-1.5-1.11.41.91.4-1.5
Bone: periosteal perimeter0.91.74.8-0.30.9-0.7-0.41.32.01.3-2.2
Bone: post-yield work0.10.20.7-0.50.8-0.5-0.10.00.50.1-0.3
Progressive ratio test 1 active lever presses1.01.82.1-1.41.4-1.3-1.31.41.41.4-1.1
Progressive ratio test 1 breakpoint1.01.72.0-1.31.3-1.3-1.31.41.41.4-1.1
Progressive ratio test 1 inactive lever presses0.30.82.5-1.01.5-1.6-0.40.20.60.3-0.4
Progressive ratio test 2 active lever presses1.01.42.5-1.01.6-1.4-0.70.81.41.0-1.3
Progressive ratio test 2 breakpoint1.01.32.3-0.91.5-1.4-0.60.81.40.9-1.3
Progressive ratio test 2 inactive lever presses0.82.56.6-1.92.6-2.4-1.00.81.20.8-0.8
Incentive Sensitization - Responses0.00.10.20.20.20.00.4-0.40.0-0.3-0.1
Incentive Sensitization - Breakpoint0.00.10.30.40.10.10.5-0.5-0.1-0.4-0.1
Sum of active levers in priming session hrs 5-60.20.20.5-0.3-0.40.4-0.70.50.30.50.4
Progressive ratio0.20.60.90.6-1.00.90.3-0.6-1.0-0.60.9
Food seeking constrained by brief footshock3.03.76.31.1-1.11.01.5-2.4-2.5-2.42.5
Seeking ratio, punishment vs. effort0.10.30.9-0.81.0-0.9-0.30.00.3-0.0-0.1
Retroperitoneal fat weight0.20.71.5-0.1-1.11.2-1.10.9-0.00.90.5
Reaction time number correct0.20.61.7-0.51.3-1.20.20.20.80.0-0.8
Reaction time mean minus median0.42.46.40.1-0.30.2-0.81.92.12.0-2.5
Reaction time mean minus median AUC0.10.72.11.1-0.90.70.60.30.70.4-1.4
Reaction time num false alarms0.20.41.70.60.10.00.5-0.00.80.3-1.3
Reaction time num false alarms AUC0.10.31.20.20.4-0.20.20.10.70.4-1.1
Reaction time trials correct on left0.20.61.7-0.51.3-1.20.20.20.80.0-0.8
Reaction time trials on left0.20.61.6-0.41.3-1.20.20.20.80.1-0.8
Reaction time mean0.91.95.61.8-2.42.30.8-0.1-0.5-0.2-0.1
Reaction time mean AUC0.92.15.62.0-2.42.31.1-0.3-0.6-0.4-0.0
Median of all reaction times2.03.27.62.2-2.82.71.3-0.9-1.4-1.00.8
Reaction time omissions0.30.41.30.8-1.21.10.20.20.00.2-0.3
Reaction time false alarm rate0.10.20.70.4-0.20.30.10.10.50.5-0.8
Reaction time premature initiation rate0.40.61.50.3-0.40.1-0.21.10.90.9-1.2
Reaction time premature initiations0.20.72.00.10.2-0.3-0.11.11.10.8-1.4
Std. dev. reaction times0.41.22.10.8-1.21.2-0.21.21.01.1-1.4
Reaction time trials completed0.20.61.6-0.41.3-1.20.20.20.80.1-0.8
Reaction time trials AUC0.10.51.2-0.21.1-1.00.40.10.7-0.1-0.9
Run reversals in cocaine runway, females1.11.21.51.0-1.11.20.9-1.2-1.2-1.01.0
Run reversals in cocaine runway, males0.40.41.40.60.4-0.41.2-0.70.1-0.9-0.4
Latency to leave start box in cocaine runway0.10.10.2-0.1-0.50.4-0.40.3-0.10.30.2
Latency to leave start box in cocaine runway, F0.30.41.2-0.9-0.0-0.0-1.10.5-0.00.70.5
Latency to leave start box in cocaine runway, M0.20.20.50.7-0.40.40.6-0.20.0-0.3-0.3
Std. dev. time between licks in bursts0.10.30.6-0.30.8-0.7-0.10.30.40.3-0.7
Total sessions with >9 infusions0.10.20.4-0.0-0.60.4-0.3-0.1-0.50.00.7
Short access day 1 total inactive lever presses0.20.31.0-0.80.4-0.1-0.7-0.2-0.5-0.11.0
Short access day 10 total inactive lever presses0.21.64.3-2.11.3-1.1-1.60.2-0.60.31.7
Short access day 1 total infusions0.71.32.00.8-1.41.40.5-1.1-1.4-0.91.4
Short access day 10 total infusions0.20.40.60.7-0.70.80.5-0.6-0.6-0.60.5
Short access total infusions0.50.81.90.6-1.41.40.1-0.4-0.9-0.30.9
Short access day 1 locomotion0.20.40.90.6-0.70.70.10.40.60.5-0.9
Short access day 10 total locomotion0.00.20.6-0.30.1-0.1-0.0-0.4-0.5-0.40.8
Short access total locomotion0.20.31.00.6-1.00.90.1-0.1-0.3-0.10.1
One hour access (0.3 mA shock)1.01.23.3-0.21.8-1.80.7-0.40.9-0.3-1.2
Compulsive drug intake1.82.73.51.9-1.51.61.9-1.8-1.6-1.80.9
One hour access (shock baseline)1.12.94.6-1.22.0-2.0-0.81.42.11.4-2.0
Social response proportion5.06.37.8-2.52.3-2.4-2.52.82.82.7-2.2
Social responses1.92.53.8-1.31.9-1.9-0.81.11.91.3-1.9
Social time1.32.04.72.2-1.61.51.9-1.3-0.6-1.1-0.3
Soleus weight0.82.34.7-1.82.2-2.1-1.31.01.21.0-0.7
Bone: stiffness0.71.32.6-0.71.0-0.9-0.71.11.61.1-1.5
Tibialis anterior weight6.321.826.7-5.24.7-4.5-5.04.84.74.9-3.4
Time to tail flick, vehicle, before self-admin0.50.62.00.6-1.41.3-0.30.5-0.30.6-0.3
Time to tail flick, vehicle, after self-admin0.10.20.70.10.2-0.10.10.40.70.3-0.8
Time to tail flick, test, before self-admin1.01.22.2-1.31.5-1.4-1.11.00.41.0-0.6
Time to tail flick, test, after self-admin0.10.10.40.1-0.40.6-0.40.4-0.10.30.1
Delta time to tail flick, vehicle, before/after SA0.30.30.80.50.4-0.30.9-0.60.1-0.7-0.3
Delta time to tail flick, test, before/after SA0.81.01.81.1-1.31.40.8-1.0-0.6-1.00.9
Tibia length3.08.416.9-4.13.0-3.0-3.82.61.92.6-0.4
Ambulatory time before self-admin0.10.20.50.4-0.40.30.10.40.30.3-0.7
Ambulatory time after self-admin0.20.41.00.9-0.30.31.0-0.5-0.3-0.6-0.4
Bone: tissue strength0.50.51.6-0.40.5-0.30.1-0.8-0.8-0.81.3
Total heroin consumption1.92.25.32.3-1.81.81.8-1.0-0.2-1.0-0.5
Bone: trabecular number1.83.57.5-2.72.1-2.1-2.31.51.01.6-0.3
Bone: trabecular spacing2.33.35.32.3-2.02.02.1-1.7-1.4-1.80.9
Bone: trabecular thickness2.43.45.8-2.42.0-2.0-2.21.71.31.8-0.8
Bone: trabecular tissue density1.42.55.4-0.2-0.1-0.1-1.12.22.02.1-2.3
Water consumed over 24 hours1.12.14.1-2.02.0-2.0-1.40.91.10.9-0.4
Number of responses in last shaping day0.20.20.60.4-0.80.60.2-0.4-0.4-0.30.4