Hub : Genes

LOC134481241

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression LOC134481241 0.03 0.02 4.0e-03 0.02 0.02 0.01 0.02 4.4e-03 1.2e-02 1.8e-02 1.2e-02
2 BLA gene expression LOC134481241 0.14 0.09 5.9e-05 0.05 0.05 0.06 0.04 1.1e-03 7.9e-04 3.8e-04 5.6e-03
3 Adipose gene expression LOC134481241 0.17 0.05 4.1e-12 0.04 0.08 0.08 0.08 2.1e-05 2.1e-09 3.3e-09 2.4e-09
4 PL gene expression LOC134481241 0.05 0.03 2.2e-04 0.02 0.03 0.04 0.03 1.0e-03 1.3e-04 3.5e-05 7.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density1.32.56.42.51.7-0.70.5
Area under the delay curve0.40.62.0-1.4-0.2-0.2-0.4
BMI with tail0.20.71.01.00.50.8-1.0
BMI without tail0.52.56.52.51.9-0.2-0.0
Body weight3.816.839.96.34.9-1.61.0
Weight adjusted by age0.30.81.41.20.8-0.60.8
Bone surface1.32.77.62.71.7-0.50.2
Bone volume0.40.72.11.50.60.3-0.5
Breakpoint value in progressive ratio session0.10.10.20.30.4-0.40.2
Number of licking bursts0.10.20.20.20.5-0.40.4
Context. condit. distance diff. score2.42.94.72.22.0-1.31.2
Locomotion velocity, session 10.10.20.4-0.7-0.40.1-0.0
Locomotion distance, session 10.50.71.8-1.3-0.90.2-0.1
Locomotion velocity, session 20.20.20.7-0.9-0.3-0.00.0
Locomotion distance, session 20.50.71.7-1.3-0.3-0.70.8
Locomotion velocity, session 30.20.20.30.40.5-0.50.5
Locomotion distance, session 30.20.20.40.20.4-0.60.5
Stereotopy head waving bouts, day 31.21.43.21.81.2-0.70.6
Stereotopy head waving duration, day 30.10.20.2-0.2-0.50.5-0.4
Locomotion velocity, session 71.71.92.2-1.3-1.51.4-1.4
Locomotion distance, session 70.20.20.6-0.8-0.30.3-0.2
Stereotopy head waving bouts, day 70.20.30.7-0.20.1-0.60.8
Stereotopy head waving duration, day 70.10.10.2-0.4-0.4-0.10.3
Locomotion velocity, session 80.00.00.00.20.2-0.10.1
Locomotion distance, session 80.60.81.11.01.1-0.80.7
Degree of sensitization distance1.01.11.2-1.1-1.01.1-0.9
Degree of sensitization stereotypy0.10.10.3-0.6-0.2-0.20.4
Conditioned locomotion0.00.00.1-0.2-0.30.2-0.2
Cocaine response after cond. corrected1.21.83.3-0.2-1.11.6-1.8
Cocaine response after cond. not corrected0.81.22.1-0.2-0.91.3-1.5
Cocaine response before conditioning0.81.01.70.20.9-1.21.3
Saline control response7.510.311.63.03.4-3.33.2
Bone: connectivity density3.45.412.93.62.4-1.41.0
Bone: cortical apparent density0.91.41.8-0.9-1.21.3-1.2
Bone: cortical area0.30.50.90.80.9-0.50.7
Bone: cortical porosity0.20.20.30.10.4-0.50.4
Bone: cortical porosity0.10.10.2-0.20.1-0.50.4
Bone: cortical thickness0.30.61.41.20.8-0.40.4
Bone: cortical thickness1.11.42.71.71.2-0.90.8
Bone: cortical tissue density0.91.41.8-1.0-1.21.3-1.2
Condit. Reinf. active minus inactive responses0.70.71.1-1.0-0.90.7-0.7
Condit. Reinf. active-inactive response ratio0.40.50.6-0.4-0.80.7-0.8
Condit. Reinf. active responses0.20.20.7-0.9-0.2-0.30.3
Condit. Reinf. inactive responses0.50.71.0-0.90.2-0.91.0
Incentive salience index mean0.30.41.2-1.1-0.50.10.1
Condit. Reinf. lever presses0.40.62.1-1.4-0.4-0.20.6
Condit. Reinf. active minus inactive responses1.21.82.91.71.5-1.20.9
Condit. Reinf. active-inactive response ratio0.20.30.70.80.5-0.40.1
Condit. Reinf. active responses1.72.43.21.51.8-1.51.4
Condit. Reinf. inactive responses0.91.41.80.81.4-1.21.3
Condit. Reinf. lever presses0.00.10.2-0.10.4-0.20.2
Condit. Reinf. lever reinforcers received1.21.62.21.01.5-1.31.2
Conditioned reinforcement - actives0.93.74.72.22.1-1.71.7
Conditioned reinforcement - inactives0.20.61.00.80.7-0.61.0
Conditioned locomotion3.04.45.82.22.4-1.81.8
Patch foraging indifference point 0 sec0.00.00.10.10.2-0.20.3
Patch foraging indifference point AUC0.51.21.71.11.3-1.00.9
Delay disc. indifference point, 0s delay2.02.24.8-0.0-1.11.7-2.2
Delay disc. indifference point, 16s delay0.40.61.3-0.80.5-1.10.6
Delay disc. indifference point, 2s delay1.51.72.4-1.5-1.01.0-1.5
Delay disc. indifference point, 24s delay0.20.31.0-1.0-0.3-0.1-0.2
Delay disc. indifference point, 4s delay1.71.92.6-1.5-1.11.2-1.6
Delay disc. indifference point, 8s delay0.40.71.2-1.00.4-1.10.7
Indifference point function ln k0.41.31.90.90.9-1.21.4
Indifference point function log k0.41.31.90.90.9-1.21.4
Patch foraging total patch changes 0 sec0.00.10.20.10.3-0.50.5
Patch foraging total patch changes 12 sec0.00.00.10.00.3-0.0-0.0
Patch foraging total patch changes 18 sec0.10.20.40.00.5-0.60.5
Patch foraging total patch changes 24 sec0.41.52.60.11.2-1.51.6
Patch foraging total patch changes 6 sec0.30.40.70.30.8-0.70.7
Patch foraging time to switch 0 sec3.613.718.0-2.4-3.64.2-4.2
Patch foraging water rate 0 sec3.412.914.53.23.6-3.83.7
Patch foraging water rate 12 sec0.73.04.01.21.6-2.02.0
Patch foraging water rate 18 sec0.51.12.30.10.8-1.21.5
Patch foraging water rate 24 sec3.85.45.92.22.4-2.32.4
Patch foraging water rate 6 sec1.82.73.01.31.7-1.71.7
Seeking ratio, delayed vs. immediate footshock1.82.53.2-1.8-1.71.5-1.2
Distance traveled before self-admin0.10.20.3-0.1-0.60.4-0.6
Distance traveled after self-admin0.20.40.70.10.3-0.80.8
Extensor digitorum longus weight3.011.818.94.34.0-2.62.4
Bone: elastic displacement0.81.11.30.81.0-1.11.1
Bone: elastic work3.44.45.72.32.4-1.91.8
Bone: endosteal estimation0.71.72.41.01.6-1.31.3
Bone: endosteal perimeter0.92.23.40.51.6-1.61.8
Epididymis fat weight0.00.10.3-0.5-0.00.2-0.2
Delta time in closed arm before/after self-admin0.30.30.60.40.8-0.70.3
Delta time in open arm before/after self-admin1.61.93.3-1.4-1.81.1-1.2
Diff in mean of infusions in LGA sessions0.40.60.80.70.8-0.90.8
Delay discount exponential model param0.50.72.71.60.20.40.2
Extinction: sum of active levers before priming0.10.10.4-0.6-0.2-0.3-0.0
Active lever presses in extinction session 60.30.30.40.70.6-0.30.4
Bone: final force0.60.91.51.21.2-0.60.6
Bone: final moment0.40.71.21.01.1-0.50.6
Food consumed during 24 hour testing period0.10.10.2-0.20.4-0.50.3
Glucose1.93.03.7-1.7-1.91.7-1.6
Heart weight1.52.53.01.41.4-1.71.7
Delay discount hyperbolic model param0.50.72.41.60.20.20.4
Intermittent access intake day 1-15 change0.21.22.01.41.0-0.71.2
Intermittent access intake escalation0.20.91.41.20.9-0.61.0
Intermittent access intake escalation 20.00.00.10.3-0.10.10.2
Intermitt. access day 1 inactive lever presses0.00.30.60.50.3-0.60.8
Intermitt. access day 15 inactive lever presses0.52.94.8-0.8-1.62.2-1.9
Intermitt. access escalation Index0.10.30.7-0.10.5-0.80.5
Intermittent access day 1 total infusions0.10.30.6-0.70.3-0.60.4
Intermittent access day 15 total infusions0.30.71.20.10.9-0.91.1
Intermittent access terminal intake (last 3 days)0.10.20.3-0.20.5-0.40.6
Intermittent access total infusions0.10.10.3-0.50.1-0.1-0.0
Intermittent access day 1 locomotion0.10.20.7-0.80.0-0.30.1
Intermittent access day 15 total locomotion0.52.02.70.81.5-1.51.7
Intermittent access total locomotion0.20.30.4-0.50.5-0.60.5
Intermittent access standard deviation0.10.71.50.4-0.81.2-0.7
Left kidney weight2.620.940.96.45.4-2.92.4
Right kidney weight1.812.729.75.54.1-1.71.2
Cocaine induced anxiety0.10.10.3-0.6-0.00.3-0.4
Post-drug Anxiety6.67.59.8-2.6-2.32.9-3.1
Baseline Anxiety4.88.010.2-2.3-2.73.0-3.2
Tail length3.217.033.05.74.9-2.62.1
Length with tail8.738.572.58.57.4-4.13.3
Length without tail2.915.030.15.54.6-2.41.8
Times rat made contact with spout0.10.10.20.30.4-0.50.3
Lifetime Intake0.20.20.5-0.7-0.30.2-0.4
Liver weight, left2.13.55.02.22.1-1.61.5
Liver weight, right1.01.83.11.81.7-0.90.7
Locomotor activity5.68.810.72.23.0-3.23.3
Locomotor testing distance2.25.36.71.82.3-2.62.5
Locomotor testing rearing0.31.11.60.70.8-1.31.2
Locomotion in novel chamber2.63.54.51.52.1-1.91.9
Locomotion in novel chamber post-restriction1.95.87.81.82.8-2.52.5
Fecal boli incidents, locomotor time 10.82.03.21.81.5-1.11.1
Change in fecal boli incidents, locomotor task0.40.40.5-0.6-0.60.7-0.7
Time >=10cm from walls, locomotor time 12.32.83.3-1.8-1.81.4-1.6
Bouts of movement, locomotor time 11.72.13.40.51.9-1.61.6
Total resting periods, locomotor time 11.71.93.30.41.8-1.51.5
Rest time, locomotor task time 10.60.92.00.91.4-0.70.7
Distance moved, locomotor task time 10.00.10.4-0.6-0.40.1-0.0
Vertical activity count, locomotor time 10.10.91.5-0.00.9-1.21.2
Time >=10cm from walls, locomotor time 20.51.42.8-0.1-0.91.5-1.7
Bouts of movement, locomotor time 20.51.62.31.11.5-1.31.2
Total resting periods, locomotor time 20.31.21.71.01.3-1.01.0
Rest time, locomotor task time 20.00.00.1-0.0-0.20.2-0.3
Distance moved, locomotor task time 20.00.00.10.10.00.10.2
Vertical activity count, locomotor time 21.02.43.11.51.5-1.41.8
Light reinforcement 10.41.73.2-1.8-1.41.1-0.7
Light reinforcement 20.20.40.5-0.6-0.60.7-0.5
Bone: marrow area0.71.62.30.91.5-1.31.3
Bone: maximum diameter0.40.91.40.71.2-0.71.0
Bone: maximum force0.61.21.91.21.4-0.90.9
Bone: maximum moment0.61.11.71.11.3-0.90.9
Mean time between licks in bursts0.10.41.2-1.1-0.3-0.10.3
Mean num. licks in bursts0.00.00.00.1-0.10.1-0.2
Cd content in liver2.52.84.70.51.2-2.22.2
Co content in liver2.73.23.71.91.7-1.81.6
Cu content in liver0.30.30.4-0.3-0.60.6-0.6
Fe content in liver0.60.70.90.60.9-0.91.0
K content in liver0.30.30.5-0.2-0.50.7-0.7
Mg content in liver0.00.10.10.30.30.0-0.1
Mn content in liver0.20.20.4-0.6-0.50.4-0.3
Na content in liver0.10.10.20.50.40.2-0.0
Rb content in liver2.32.65.9-2.4-1.61.1-0.9
Se content in liver0.30.30.60.5-0.00.7-0.8
Sr content in liver0.50.50.80.10.8-0.70.9
Zn content in liver3.84.46.02.42.4-1.71.6
Bone: minimum diameter0.20.31.1-1.1-0.2-0.20.4
Time in familiar zone, hab. session 11.01.11.4-0.7-1.11.2-1.1
Time in novel zone, hab. session 10.30.30.70.80.6-0.40.3
Total zone transitions, hab. session 10.60.82.6-1.6-0.80.00.2
Total locomotion distance, hab. session 10.50.71.0-1.0-1.00.6-0.7
Locomotion velocity, hab. session 10.91.32.6-1.6-1.30.6-0.6
Time in familiar zone, hab. session 20.60.61.1-0.2-0.61.0-1.1
Time in novel zone, hab. session 20.30.30.6-0.40.2-0.60.8
Total zone transitions, hab. session 20.30.40.7-0.00.5-0.70.8
Total locomotion distance, hab. session 20.10.10.3-0.5-0.2-0.10.2
Locomotion velocity, hab. session 20.10.10.3-0.5-0.2-0.10.2
Novel to familiar place preference ratio0.00.00.00.1-0.1-0.1-0.0
Novelty place preference0.10.10.2-0.3-0.50.1-0.2
Time in novel zone, NPP test0.00.10.2-0.1-0.40.1-0.2
Total zone transitions, NPP test0.10.10.2-0.30.1-0.20.5
Total locomotion distance, NPP test0.10.20.5-0.7-0.40.3-0.2
Locomotion velocity, NPP test0.10.10.2-0.40.1-0.40.5
Intraocular pressure1.01.72.61.41.6-1.01.0
Delta distance traveled before/after self-admin0.90.91.70.10.8-1.21.3
Delta ambulatory time before/after self-admin0.10.20.4-0.5-0.1-0.50.7
Parametrial fat weight0.71.73.30.4-1.01.5-1.8
Pavlov. Cond. lever latency2.02.66.02.51.6-1.00.8
Pavlov. Cond. magazine entry latency0.30.40.60.40.8-0.60.8
Pavlov. Cond. change in total contacts1.82.02.5-1.6-1.41.3-1.3
Pavlov. Cond. index score0.20.20.6-0.8-0.40.3-0.1
Pavlov. Cond. latency score0.50.61.5-1.2-0.70.5-0.3
Pavlov. Cond. lever contacts2.02.55.3-2.3-1.61.1-0.9
Pavlov. Cond. magazine entry number0.40.50.7-0.3-0.70.7-0.9
Pavlov. Cond. intertrial magazine entries0.10.10.4-0.6-0.3-0.30.2
Pavlov. Cond. lever-magazine prob. diff.0.30.30.7-0.8-0.50.5-0.4
Pavlov. Cond. response bias0.10.10.1-0.20.3-0.20.4
Pavlov. Cond. lever latency0.20.30.90.90.5-0.40.3
Pavlov. Cond. magazine entry latency1.62.33.5-1.9-1.71.2-1.2
Pavlov. Cond. change in total contacts0.00.10.2-0.50.2-0.30.2
Pavlov. Cond. index score0.61.02.6-1.6-0.90.5-0.4
Pavlov. Cond. latency score0.60.92.2-1.5-0.90.6-0.6
Pavlov. Cond. lever contacts0.30.41.1-1.1-0.50.4-0.3
Pavlov. Cond. magazine entry number0.81.02.01.41.1-0.60.7
Pavlov. Cond. intertrial magazine entries0.81.72.40.81.3-1.41.6
Pavlov. Cond. lever-magazine prob. diff.0.61.02.7-1.6-0.90.5-0.4
Pavlov. Cond. response bias0.50.71.8-1.4-0.80.5-0.4
Time in closed arm before self-admin2.23.84.31.92.0-1.82.1
Time in closed arm after self-admin4.95.56.52.02.6-2.42.3
Time in open arm before self-admin0.10.10.2-0.10.4-0.40.1
Time in open arm after self-admin1.41.62.2-1.1-1.51.2-1.3
Bone: periosteal estimation0.61.52.21.01.5-1.11.2
Bone: periosteal perimeter0.61.22.20.11.1-1.31.5
Bone: post-yield work0.40.70.90.80.9-0.80.8
Progressive ratio test 1 active lever presses0.71.21.61.31.3-1.00.8
Progressive ratio test 1 breakpoint0.71.21.61.21.3-1.00.8
Progressive ratio test 1 inactive lever presses0.82.02.31.31.4-1.51.5
Progressive ratio test 2 active lever presses1.82.63.41.21.9-1.61.7
Progressive ratio test 2 breakpoint2.02.53.31.11.8-1.71.7
Progressive ratio test 2 inactive lever presses1.85.76.52.62.4-2.22.4
Incentive Sensitization - Responses0.10.20.3-0.20.5-0.40.6
Incentive Sensitization - Breakpoint0.10.20.4-0.20.5-0.40.6
Sum of active levers in priming session hrs 5-60.50.51.0-0.2-0.50.7-1.0
Progressive ratio0.82.43.1-1.0-1.51.7-1.8
Food seeking constrained by brief footshock1.51.92.6-1.6-1.61.4-0.8
Seeking ratio, punishment vs. effort0.61.42.30.61.2-1.31.5
Retroperitoneal fat weight0.83.45.1-1.1-1.72.1-2.3
Reaction time number correct0.82.83.61.31.7-1.81.9
Reaction time mean minus median0.00.10.3-0.5-0.30.00.1
Reaction time mean minus median AUC0.00.20.5-0.7-0.4-0.00.1
Reaction time num false alarms0.20.40.70.30.5-0.80.7
Reaction time num false alarms AUC0.20.50.70.60.6-0.90.7
Reaction time trials correct on left0.82.83.61.31.7-1.81.9
Reaction time trials on left0.82.73.41.21.7-1.71.8
Reaction time mean1.32.93.9-1.9-2.01.5-1.4
Reaction time mean AUC1.02.43.5-1.7-1.91.3-1.2
Median of all reaction times2.84.45.6-2.2-2.41.9-1.8
Reaction time omissions0.91.51.8-1.1-1.31.3-1.1
Reaction time false alarm rate0.00.00.00.0-0.2-0.1-0.1
Reaction time premature initiation rate0.10.10.2-0.2-0.30.4-0.4
Reaction time premature initiations0.10.20.20.30.5-0.40.4
Std. dev. reaction times0.31.11.8-1.3-1.20.9-0.7
Reaction time trials completed0.82.73.41.21.7-1.71.8
Reaction time trials AUC0.72.53.51.11.6-1.71.9
Run reversals in cocaine runway, females1.11.21.7-1.1-1.31.1-0.9
Run reversals in cocaine runway, males1.51.72.90.31.1-1.61.7
Latency to leave start box in cocaine runway0.60.81.4-0.3-0.81.0-1.2
Latency to leave start box in cocaine runway, F0.70.91.70.2-0.71.2-1.3
Latency to leave start box in cocaine runway, M0.10.10.2-0.4-0.2-0.10.0
Std. dev. time between licks in bursts0.50.91.00.81.0-1.01.0
Total sessions with >9 infusions0.70.91.2-0.4-1.01.1-1.1
Short access day 1 total inactive lever presses0.10.20.5-0.1-0.50.7-0.5
Short access day 10 total inactive lever presses0.10.51.61.30.10.6-0.3
Short access day 1 total infusions0.91.82.3-1.3-1.51.2-1.3
Short access day 10 total infusions0.30.40.7-0.8-0.70.4-0.5
Short access total infusions1.52.22.6-1.3-1.51.4-1.6
Short access day 1 locomotion0.10.20.6-0.8-0.2-0.1-0.2
Short access day 10 total locomotion0.00.00.0-0.0-0.20.10.1
Short access total locomotion0.71.01.2-1.1-1.10.9-1.0
One hour access (0.3 mA shock)5.16.09.61.32.3-2.73.1
Compulsive drug intake0.71.01.9-1.4-1.20.6-0.5
One hour access (shock baseline)1.74.45.41.72.3-2.22.2
Social response proportion2.43.15.12.22.0-1.41.1
Social responses3.64.75.32.02.3-2.22.1
Social time0.60.92.7-1.6-1.00.3-0.1
Soleus weight1.03.14.32.12.1-1.51.3
Bone: stiffness0.10.20.40.40.6-0.40.4
Tibialis anterior weight2.48.116.04.03.3-1.81.5
Time to tail flick, vehicle, before self-admin1.51.82.2-1.5-1.11.3-1.5
Time to tail flick, vehicle, after self-admin0.10.20.2-0.20.5-0.50.4
Time to tail flick, test, before self-admin1.01.21.61.31.1-1.00.9
Time to tail flick, test, after self-admin1.01.11.6-0.7-1.01.2-1.3
Delta time to tail flick, vehicle, before/after SA0.60.61.00.30.6-1.01.0
Delta time to tail flick, test, before/after SA1.62.02.4-1.6-1.41.4-1.2
Tibia length1.13.07.72.82.0-0.40.0
Ambulatory time before self-admin0.00.00.10.30.2-0.20.0
Ambulatory time after self-admin0.10.20.3-0.20.0-0.60.6
Bone: tissue strength0.20.20.30.50.4-0.30.2
Total heroin consumption0.70.82.9-1.7-0.6-0.2-0.0
Bone: trabecular number1.32.57.02.61.6-0.50.3
Bone: trabecular spacing1.92.86.4-2.5-1.71.0-0.8
Bone: trabecular thickness1.52.14.42.11.7-0.80.7
Bone: trabecular tissue density0.20.30.3-0.5-0.50.6-0.6
Water consumed over 24 hours0.91.82.31.31.5-1.31.1
Number of responses in last shaping day0.81.01.3-0.9-1.10.9-1.0