Hub : Genes

LOC134481239

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	alternative polyA	XR_010056646.1	0.37	0.2	1.5e-03	0.17	0.16	0.14	0.18	1.5e-03	1.9e-03	3.5e-03	9.3e-04
2	Eye	alternative polyA	XR_010056647.1	0.38	0.2	1.0e-03	0.17	0.17	0.17	0.19	1.2e-03	1.3e-03	1.2e-03	7.5e-04
3	NAcc	alternative polyA	XR_010056647.1	0.03	0.03	5.2e-03	-0	0.01	0.01	0	4.1e-01	1.4e-02	5.0e-03	7.1e-02
4	NAcc	alternative polyA	XR_010056646.1	0.03	0.03	3.0e-03	0	0.01	0.01	0.01	1.0e-01	6.1e-03	1.9e-03	3.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	2.3	4.0	7.4	-2.7	2.7	0.8	-0.6
Area under the delay curve	1.3	1.5	1.7	1.2	-1.2	-1.3	1.3
BMI with tail	1.1	3.9	5.8	-2.4	2.4	-1.3	1.5
BMI without tail	1.5	4.6	8.9	-3.0	3.0	-0.4	0.6
Body weight	6.6	29.0	57.9	-7.6	7.6	0.5	-0.0
Weight adjusted by age	0.4	0.7	0.9	-0.9	0.9	0.7	-0.7
Bone surface	2.1	3.9	7.7	-2.8	2.8	0.3	-0.1
Bone volume	1.0	1.8	3.5	-1.9	1.9	-0.3	0.4
Breakpoint value in progressive ratio session	0.3	0.4	0.7	-0.3	0.3	-0.8	0.8
Number of licking bursts	0.1	0.1	0.2	0.0	-0.0	0.5	-0.5
Context. condit. distance diff. score	1.6	2.0	3.2	-1.8	1.8	0.9	-0.8
Locomotion velocity, session 1	0.2	0.3	0.5	0.7	-0.7	0.1	-0.2
Locomotion distance, session 1	1.2	1.5	3.1	1.8	-1.8	-0.1	-0.1
Locomotion velocity, session 2	0.2	0.3	0.5	0.7	-0.7	-0.1	-0.0
Locomotion distance, session 2	2.6	3.7	7.0	2.6	-2.6	0.5	-0.7
Locomotion velocity, session 3	0.3	0.4	0.5	-0.5	0.5	0.7	-0.7
Locomotion distance, session 3	0.1	0.1	0.3	0.1	-0.1	0.5	-0.5
Stereotopy head waving bouts, day 3	1.8	2.1	3.4	-1.8	1.8	0.9	-0.8
Stereotopy head waving duration, day 3	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1
Locomotion velocity, session 7	1.2	1.3	2.0	0.8	-0.8	-1.4	1.4
Locomotion distance, session 7	0.5	0.7	0.9	1.0	-1.0	-0.7	0.6
Stereotopy head waving bouts, day 7	1.0	1.1	2.0	0.6	-0.6	1.3	-1.4
Stereotopy head waving duration, day 7	0.5	0.6	0.8	0.6	-0.6	0.8	-0.9
Locomotion velocity, session 8	0.1	0.1	0.2	-0.4	0.4	0.2	-0.1
Locomotion distance, session 8	0.1	0.1	0.2	-0.4	0.4	0.2	-0.2
Degree of sensitization distance	1.6	1.6	1.9	1.2	-1.2	-1.4	1.3
Degree of sensitization stereotypy	0.5	0.5	0.7	0.8	-0.8	0.6	-0.7
Conditioned locomotion	0.1	0.1	0.2	-0.5	0.5	0.1	-0.0
Cocaine response after cond. corrected	1.7	2.1	2.5	-1.4	1.4	-1.5	1.6
Cocaine response after cond. not corrected	1.5	1.7	2.5	-1.1	1.1	-1.5	1.6
Cocaine response before conditioning	0.4	0.5	0.6	0.7	-0.7	0.7	-0.8
Saline control response	4.3	5.7	8.4	-1.8	1.8	2.9	-2.8
Bone: connectivity density	4.4	6.8	12.2	-3.5	3.5	1.3	-1.1
Bone: cortical apparent density	0.8	1.1	2.0	0.4	-0.4	-1.4	1.4
Bone: cortical area	0.1	0.2	0.3	-0.5	0.5	0.3	-0.2
Bone: cortical porosity	0.2	0.2	0.4	0.0	-0.0	0.6	-0.6
Bone: cortical porosity	0.4	0.5	0.5	0.7	-0.7	0.7	-0.7
Bone: cortical thickness	0.2	0.4	0.8	-0.9	0.9	0.2	-0.2
Bone: cortical thickness	0.2	0.2	0.2	-0.4	0.4	0.5	-0.5
Bone: cortical tissue density	0.8	1.1	2.0	0.5	-0.5	-1.4	1.4
Condit. Reinf. active minus inactive responses	0.6	0.6	0.9	0.7	-0.7	-1.0	0.9
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.1	0.1	-0.6	0.6
Condit. Reinf. active responses	0.5	0.6	1.1	1.1	-1.1	-0.2	0.1
Condit. Reinf. inactive responses	1.5	1.8	3.3	1.8	-1.8	0.5	-0.6
Incentive salience index mean	0.7	0.8	1.6	1.3	-1.3	-0.3	0.2
Condit. Reinf. lever presses	1.1	1.6	3.1	1.8	-1.8	0.2	-0.4
Condit. Reinf. active minus inactive responses	0.8	1.0	1.6	-1.3	1.3	0.6	-0.6
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	-0.8	0.8	0.1	-0.1
Condit. Reinf. active responses	0.7	0.9	1.0	-1.0	1.0	0.9	-0.9
Condit. Reinf. inactive responses	0.4	0.5	0.9	-0.3	0.3	0.9	-0.9
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.1	0.1	-0.3	0.3
Condit. Reinf. lever reinforcers received	0.3	0.4	0.6	-0.4	0.4	0.8	-0.7
Conditioned reinforcement - actives	2.2	3.8	4.8	-2.2	2.2	1.7	-1.6
Conditioned reinforcement - inactives	0.8	1.1	2.0	-0.6	0.6	1.4	-1.4
Conditioned locomotion	1.7	2.2	2.8	-1.7	1.7	1.3	-1.2
Patch foraging indifference point 0 sec	0.1	0.2	0.4	-0.0	0.0	0.6	-0.6
Patch foraging indifference point AUC	0.4	0.6	1.0	-1.0	1.0	0.5	-0.4
Delay disc. indifference point, 0s delay	2.8	3.0	5.5	-0.9	0.9	-2.2	2.3
Delay disc. indifference point, 16s delay	0.3	0.4	0.6	0.8	-0.8	-0.4	0.4
Delay disc. indifference point, 2s delay	3.0	3.4	5.0	1.3	-1.3	-2.2	2.2
Delay disc. indifference point, 24s delay	0.5	0.6	1.0	1.0	-1.0	-0.5	0.4
Delay disc. indifference point, 4s delay	2.1	2.2	3.1	1.1	-1.1	-1.8	1.7
Delay disc. indifference point, 8s delay	0.4	0.5	1.0	1.0	-1.0	-0.1	0.0
Indifference point function ln k	0.8	1.5	3.0	0.2	-0.2	1.7	-1.7
Indifference point function log k	0.8	1.5	3.0	0.2	-0.2	1.7	-1.7
Patch foraging total patch changes 0 sec	0.2	0.3	0.6	0.2	-0.2	0.7	-0.8
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	-0.5	0.5	-0.0	0.1
Patch foraging total patch changes 18 sec	0.2	0.3	0.5	-0.2	0.2	0.7	-0.7
Patch foraging total patch changes 24 sec	0.5	0.9	1.9	0.1	-0.1	1.3	-1.4
Patch foraging total patch changes 6 sec	0.2	0.3	0.5	-0.4	0.4	0.7	-0.7
Patch foraging time to switch 0 sec	3.6	7.4	15.0	0.3	-0.2	-3.8	3.9
Patch foraging water rate 0 sec	3.9	8.2	14.7	-1.3	1.3	3.8	-3.8
Patch foraging water rate 12 sec	1.6	3.3	6.5	-0.3	0.3	2.5	-2.6
Patch foraging water rate 18 sec	1.0	1.5	2.3	0.9	-0.9	1.4	-1.5
Patch foraging water rate 24 sec	2.2	3.1	5.7	-0.8	0.8	2.4	-2.3
Patch foraging water rate 6 sec	1.5	2.1	4.1	-0.4	0.4	2.0	-2.0
Seeking ratio, delayed vs. immediate footshock	0.6	0.8	1.1	1.0	-1.0	-0.7	0.7
Distance traveled before self-admin	0.3	0.4	0.4	0.6	-0.6	-0.7	0.6
Distance traveled after self-admin	0.4	0.5	0.8	0.6	-0.6	0.8	-0.9
Extensor digitorum longus weight	2.1	8.4	13.1	-3.6	3.6	2.0	-1.8
Bone: elastic displacement	0.4	0.4	0.7	-0.4	0.4	0.9	-0.9
Bone: elastic work	2.0	2.6	3.6	-1.9	1.9	1.3	-1.2
Bone: endosteal estimation	0.3	0.8	0.9	-0.8	0.8	1.0	-0.9
Bone: endosteal perimeter	0.5	1.1	2.2	0.0	-0.0	1.5	-1.5
Epididymis fat weight	0.0	0.1	0.1	0.3	-0.3	-0.3	0.3
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	-0.7	0.7	0.2	-0.1
Delta time in open arm before/after self-admin	2.7	2.6	4.4	2.1	-2.1	-1.0	0.9
Diff in mean of infusions in LGA sessions	0.1	0.2	0.3	-0.3	0.3	0.5	-0.5
Delay discount exponential model param	1.8	2.0	2.6	-1.6	1.6	1.3	-1.2
Extinction: sum of active levers before priming	0.3	0.3	0.4	0.6	-0.6	-0.4	0.4
Active lever presses in extinction session 6	0.1	0.1	0.1	-0.2	0.2	0.3	-0.3
Bone: final force	0.8	1.2	2.4	-1.5	1.5	0.3	-0.2
Bone: final moment	0.6	0.9	1.7	-1.3	1.3	0.4	-0.3
Food consumed during 24 hour testing period	0.1	0.2	0.2	0.5	-0.5	0.2	-0.3
Glucose	1.7	2.6	2.8	1.7	-1.6	-1.7	1.5
Heart weight	1.3	2.0	3.9	0.0	-0.0	2.0	-2.0
Delay discount hyperbolic model param	1.7	1.9	2.2	-1.5	1.5	1.3	-1.2
Intermittent access intake day 1-15 change	1.1	2.2	3.0	-1.2	1.2	1.7	-1.7
Intermittent access intake escalation	1.0	2.0	2.5	-1.2	1.2	1.6	-1.5
Intermittent access intake escalation 2	0.3	0.3	0.7	0.0	-0.0	0.8	-0.8
Intermitt. access day 1 inactive lever presses	0.2	0.7	1.2	-0.4	0.4	1.1	-1.1
Intermitt. access day 15 inactive lever presses	0.5	1.1	2.0	-0.3	0.3	-1.4	1.4
Intermitt. access escalation Index	0.1	0.1	0.2	0.5	-0.5	-0.0	0.0
Intermittent access day 1 total infusions	0.2	0.3	0.6	0.8	-0.8	0.1	-0.2
Intermittent access day 15 total infusions	0.4	0.6	1.1	-0.1	0.1	1.1	-1.1
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.3	0.2	-0.2	0.5	-0.5
Intermittent access total infusions	0.1	0.1	0.1	0.2	-0.2	-0.4	0.4
Intermittent access day 1 locomotion	0.7	0.9	1.1	1.0	-1.0	-0.9	0.9
Intermittent access day 15 total locomotion	0.5	0.9	1.9	-0.1	0.1	1.4	-1.4
Intermittent access total locomotion	0.2	0.2	0.4	0.6	-0.6	-0.0	0.0
Intermittent access standard deviation	0.2	0.3	0.5	-0.7	0.7	-0.4	0.4
Left kidney weight	5.7	26.4	47.2	-6.9	6.9	2.6	-2.1
Right kidney weight	4.5	20.7	40.0	-6.3	6.3	1.4	-0.9
Cocaine induced anxiety	0.2	0.2	0.3	0.3	-0.3	-0.6	0.6
Post-drug Anxiety	5.8	6.2	11.3	1.1	-1.1	-3.4	3.3
Baseline Anxiety	4.1	4.7	9.0	0.7	-0.7	-3.0	3.0
Tail length	4.3	16.9	31.2	-5.6	5.6	1.8	-1.4
Length with tail	9.5	41.3	75.7	-8.7	8.7	2.9	-2.4
Length without tail	6.0	19.3	36.6	-6.1	6.0	1.6	-1.2
Times rat made contact with spout	0.3	0.3	0.5	-0.4	0.4	0.7	-0.7
Lifetime Intake	0.3	0.3	0.6	0.3	-0.3	-0.7	0.7
Liver weight, left	2.5	4.2	5.1	-2.3	2.3	1.9	-1.8
Liver weight, right	1.3	2.3	4.4	-2.1	2.1	0.4	-0.3
Locomotor activity	4.4	6.9	11.2	-1.7	1.6	3.3	-3.3
Locomotor testing distance	2.4	4.4	7.5	-1.2	1.2	2.7	-2.7
Locomotor testing rearing	0.4	0.7	1.4	-0.3	0.3	1.2	-1.2
Locomotion in novel chamber	1.7	2.1	2.8	-1.2	1.2	1.7	-1.6
Locomotion in novel chamber post-restriction	2.9	4.7	7.5	-1.4	1.4	2.7	-2.7
Fecal boli incidents, locomotor time 1	1.0	1.4	1.6	-1.3	1.3	1.2	-1.1
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	0.3	-0.3	-0.8	0.8
Time >=10cm from walls, locomotor time 1	1.8	1.9	2.9	1.0	-1.0	-1.7	1.7
Bouts of movement, locomotor time 1	1.2	1.3	1.4	-1.2	1.2	1.1	-1.1
Total resting periods, locomotor time 1	1.2	1.3	1.4	-1.2	1.2	1.1	-1.0
Rest time, locomotor task time 1	1.2	1.5	2.5	-1.6	1.6	0.7	-0.6
Distance moved, locomotor task time 1	0.5	0.8	1.1	1.0	-1.0	-0.7	0.7
Vertical activity count, locomotor time 1	0.1	0.2	0.4	0.2	-0.2	0.6	-0.6
Time >=10cm from walls, locomotor time 2	0.7	1.1	1.2	-1.1	1.1	-1.0	1.1
Bouts of movement, locomotor time 2	0.6	1.0	1.2	-0.9	0.9	1.1	-1.0
Total resting periods, locomotor time 2	0.5	0.9	0.9	-0.9	0.9	1.0	-0.9
Rest time, locomotor task time 2	0.2	0.2	0.4	0.6	-0.6	-0.3	0.2
Distance moved, locomotor task time 2	0.2	0.3	0.4	-0.6	0.6	0.3	-0.3
Vertical activity count, locomotor time 2	2.4	3.3	3.5	-1.8	1.8	1.9	-1.8
Light reinforcement 1	0.8	1.9	3.3	1.8	-1.8	-0.7	0.6
Light reinforcement 2	0.1	0.2	0.3	0.3	-0.3	-0.5	0.5
Bone: marrow area	0.3	0.7	0.9	-0.8	0.8	1.0	-0.9
Bone: maximum diameter	0.1	0.3	0.3	-0.5	0.5	0.5	-0.5
Bone: maximum force	0.4	0.7	1.2	-1.1	1.1	0.4	-0.3
Bone: maximum moment	0.3	0.5	0.8	-0.9	0.9	0.4	-0.4
Mean time between licks in bursts	0.3	0.7	1.5	1.2	-1.2	-0.1	0.1
Mean num. licks in bursts	0.1	0.1	0.2	-0.5	0.5	0.1	-0.0
Cd content in liver	2.7	3.0	5.2	1.0	-1.0	2.2	-2.3
Co content in liver	1.6	1.8	2.1	-1.3	1.3	1.5	-1.4
Cu content in liver	0.0	0.0	0.0	0.1	-0.1	-0.2	0.2
Fe content in liver	0.1	0.1	0.2	0.1	-0.1	0.5	-0.5
K content in liver	0.4	0.4	0.7	-0.5	0.5	-0.8	0.8
Mg content in liver	0.2	0.2	0.3	-0.5	0.5	-0.3	0.3
Mn content in liver	0.2	0.2	0.4	0.6	-0.6	-0.1	0.0
Na content in liver	0.6	0.6	0.9	-0.9	0.9	-0.5	0.6
Rb content in liver	2.3	2.7	4.5	2.1	-2.1	-1.0	0.9
Se content in liver	0.7	0.9	1.5	-1.2	1.2	-0.5	0.6
Sr content in liver	0.4	0.3	0.6	-0.1	0.1	0.8	-0.8
Zn content in liver	3.7	4.1	5.9	-2.4	2.4	1.6	-1.4
Bone: minimum diameter	0.4	0.7	1.4	1.2	-1.2	0.1	-0.2
Time in familiar zone, hab. session 1	0.4	0.4	0.8	0.2	-0.2	-0.8	0.9
Time in novel zone, hab. session 1	0.0	0.0	0.1	-0.3	0.3	-0.0	0.0
Total zone transitions, hab. session 1	2.2	3.1	6.2	2.5	-2.5	-0.2	-0.0
Total locomotion distance, hab. session 1	1.4	1.9	3.0	1.7	-1.7	-1.0	0.9
Locomotion velocity, hab. session 1	1.5	2.1	3.9	2.0	-2.0	-0.6	0.5
Time in familiar zone, hab. session 2	0.4	0.5	0.5	-0.6	0.6	-0.7	0.7
Time in novel zone, hab. session 2	0.9	0.9	1.5	1.2	-1.2	0.4	-0.5
Total zone transitions, hab. session 2	0.2	0.2	0.3	0.5	-0.5	0.3	-0.3
Total locomotion distance, hab. session 2	0.6	0.8	1.7	1.3	-1.3	-0.2	0.2
Locomotion velocity, hab. session 2	0.7	0.9	1.8	1.3	-1.3	-0.4	0.3
Novel to familiar place preference ratio	0.0	0.0	0.0	0.2	-0.2	-0.0	-0.0
Novelty place preference	0.2	0.2	0.3	0.6	-0.6	-0.1	0.1
Time in novel zone, NPP test	0.0	0.0	0.1	0.3	-0.3	-0.1	0.0
Total zone transitions, NPP test	0.3	0.4	0.9	0.9	-0.9	0.1	-0.2
Total locomotion distance, NPP test	0.7	1.0	1.4	1.2	-1.2	-0.8	0.7
Locomotion velocity, NPP test	0.6	0.9	1.8	1.3	-1.3	-0.2	0.1
Intraocular pressure	0.7	1.0	1.5	-1.2	1.2	0.8	-0.7
Delta distance traveled before/after self-admin	1.3	1.3	2.7	-0.1	0.1	1.6	-1.7
Delta ambulatory time before/after self-admin	0.5	0.6	1.0	0.6	-0.6	0.9	-1.0
Parametrial fat weight	0.8	1.9	2.7	-1.1	1.1	-1.5	1.6
Pavlov. Cond. lever latency	2.4	3.0	5.7	-2.4	2.4	0.7	-0.5
Pavlov. Cond. magazine entry latency	0.2	0.3	0.4	-0.5	0.5	0.6	-0.6
Pavlov. Cond. change in total contacts	0.8	0.8	1.2	0.7	-0.7	-1.1	1.1
Pavlov. Cond. index score	0.1	0.1	0.2	0.5	-0.5	-0.0	-0.0
Pavlov. Cond. latency score	0.4	0.5	0.9	1.0	-1.0	-0.2	0.2
Pavlov. Cond. lever contacts	2.1	2.5	4.3	2.1	-2.1	-0.8	0.7
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	0.2	-0.2	-0.8	0.8
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.5	1.2	-1.2	0.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	0.3	-0.3	-0.3	0.2
Pavlov. Cond. response bias	0.0	0.0	0.1	0.1	-0.1	0.2	-0.2
Pavlov. Cond. lever latency	0.3	0.4	0.4	-0.7	0.7	0.6	-0.5
Pavlov. Cond. magazine entry latency	1.6	1.9	2.5	1.6	-1.6	-1.2	1.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.5	-0.5	-0.2	0.1
Pavlov. Cond. index score	0.9	1.2	1.8	1.4	-1.4	-0.7	0.7
Pavlov. Cond. latency score	0.7	0.9	1.2	1.1	-1.1	-0.9	0.8
Pavlov. Cond. lever contacts	0.4	0.6	0.9	0.9	-0.9	-0.6	0.5
Pavlov. Cond. magazine entry number	0.9	1.1	1.7	-1.3	1.3	0.8	-0.7
Pavlov. Cond. intertrial magazine entries	0.7	1.1	2.2	-0.0	0.0	1.5	-1.5
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	2.2	1.5	-1.5	-0.7	0.6
Pavlov. Cond. response bias	0.8	1.1	1.9	1.4	-1.4	-0.6	0.5
Time in closed arm before self-admin	1.5	2.0	3.3	-0.8	0.8	1.8	-1.8
Time in closed arm after self-admin	2.5	2.6	4.4	-1.0	1.0	2.1	-2.0
Time in open arm before self-admin	0.0	0.0	0.0	-0.0	0.0	-0.0	0.0
Time in open arm after self-admin	1.9	2.1	2.2	1.4	-1.4	-1.5	1.4
Bone: periosteal estimation	0.3	0.6	0.6	-0.8	0.8	0.8	-0.7
Bone: periosteal perimeter	0.5	0.9	1.7	0.4	-0.4	1.3	-1.3
Bone: post-yield work	0.1	0.1	0.2	0.1	-0.1	0.5	-0.5
Progressive ratio test 1 active lever presses	0.8	1.0	1.8	-1.4	1.4	0.4	-0.4
Progressive ratio test 1 breakpoint	0.8	1.0	1.8	-1.3	1.3	0.4	-0.3
Progressive ratio test 1 inactive lever presses	1.4	2.1	3.2	-0.9	0.9	1.8	-1.8
Progressive ratio test 2 active lever presses	1.7	2.0	2.6	-1.2	1.2	1.6	-1.5
Progressive ratio test 2 breakpoint	1.6	1.9	2.6	-1.1	1.1	1.6	-1.5
Progressive ratio test 2 inactive lever presses	2.8	4.5	5.9	-1.8	1.8	2.4	-2.4
Incentive Sensitization - Responses	0.2	0.3	0.7	0.0	-0.0	0.8	-0.8
Incentive Sensitization - Breakpoint	0.3	0.4	0.7	0.2	-0.2	0.8	-0.9
Sum of active levers in priming session hrs 5-6	1.1	1.0	1.9	-0.5	0.5	-1.3	1.4
Progressive ratio	0.6	0.9	1.5	0.6	-0.6	-1.2	1.2
Food seeking constrained by brief footshock	0.3	0.4	0.8	0.9	-0.9	0.1	-0.2
Seeking ratio, punishment vs. effort	1.0	1.4	2.2	-0.8	0.8	1.5	-1.5
Retroperitoneal fat weight	0.5	2.1	4.3	-0.3	0.3	-2.0	2.1
Reaction time number correct	1.2	2.2	4.3	-0.4	0.4	2.1	-2.1
Reaction time mean minus median	0.1	0.3	0.6	0.8	-0.7	-0.1	0.0
Reaction time mean minus median AUC	0.4	1.0	1.8	1.4	-1.4	0.2	-0.3
Reaction time num false alarms	0.4	0.6	1.0	0.5	-0.5	1.0	-1.0
Reaction time num false alarms AUC	0.3	0.4	0.8	0.1	-0.1	0.9	-0.9
Reaction time trials correct on left	1.2	2.2	4.3	-0.4	0.4	2.1	-2.1
Reaction time trials on left	1.1	2.1	4.1	-0.4	0.4	2.0	-2.0
Reaction time mean	1.2	2.0	2.9	1.7	-1.7	-1.1	1.0
Reaction time mean AUC	1.0	1.7	2.8	1.7	-1.7	-0.8	0.7
Median of all reaction times	1.8	2.5	3.1	1.8	-1.8	-1.4	1.3
Reaction time omissions	0.6	0.9	1.1	0.8	-0.8	-1.1	1.0
Reaction time false alarm rate	0.0	0.0	0.1	0.3	-0.3	-0.0	0.0
Reaction time premature initiation rate	0.2	0.2	0.3	0.5	-0.5	-0.5	0.5
Reaction time premature initiations	0.1	0.2	0.2	0.3	-0.3	0.4	-0.5
Std. dev. reaction times	0.5	1.0	1.6	1.3	-1.2	-0.7	0.6
Reaction time trials completed	1.1	2.1	4.1	-0.4	0.4	2.0	-2.0
Reaction time trials AUC	1.2	2.2	4.6	-0.1	0.1	2.1	-2.1
Run reversals in cocaine runway, females	0.7	0.7	1.1	1.0	-1.0	-0.6	0.5
Run reversals in cocaine runway, males	1.7	1.7	3.2	0.5	-0.5	1.7	-1.8
Latency to leave start box in cocaine runway	0.6	0.6	1.3	-0.1	0.1	-1.1	1.1
Latency to leave start box in cocaine runway, F	0.7	0.8	0.9	-0.9	0.9	-0.8	0.8
Latency to leave start box in cocaine runway, M	0.6	0.5	0.8	0.9	-0.9	-0.5	0.4
Std. dev. time between licks in bursts	0.5	0.7	1.2	-0.4	0.4	1.1	-1.1
Total sessions with >9 infusions	0.3	0.4	0.8	0.1	-0.1	-0.9	0.9
Short access day 1 total inactive lever presses	0.2	0.2	0.5	-0.7	0.7	0.1	-0.1
Short access day 10 total inactive lever presses	0.8	2.0	4.0	-2.0	2.0	0.3	-0.2
Short access day 1 total infusions	0.9	1.1	1.7	0.8	-0.8	-1.3	1.3
Short access day 10 total infusions	0.3	0.3	0.6	0.8	-0.8	-0.3	0.2
Short access total infusions	1.3	1.6	2.9	0.6	-0.6	-1.7	1.7
Short access day 1 locomotion	0.3	0.4	0.5	0.5	-0.5	-0.7	0.7
Short access day 10 total locomotion	0.0	0.0	0.0	-0.0	0.0	0.1	-0.1
Short access total locomotion	0.8	1.0	1.5	0.7	-0.7	-1.2	1.2
One hour access (0.3 mA shock)	4.2	4.9	9.6	-0.4	0.4	3.1	-3.1
Compulsive drug intake	1.3	1.5	3.0	1.7	-1.7	-0.2	0.1
One hour access (shock baseline)	1.7	2.6	3.6	-1.3	1.3	1.9	-1.8
Social response proportion	3.5	4.0	7.4	-2.7	2.7	0.8	-0.7
Social responses	2.0	2.6	2.9	-1.6	1.6	1.7	-1.6
Social time	1.8	2.5	4.8	2.2	-2.2	-0.4	0.2
Soleus weight	0.7	2.0	2.2	-1.5	1.5	1.4	-1.3
Bone: stiffness	0.1	0.1	0.2	-0.4	0.4	0.1	-0.1
Tibialis anterior weight	3.0	10.1	19.0	-4.4	4.4	1.3	-1.0
Time to tail flick, vehicle, before self-admin	1.6	1.6	3.2	0.4	-0.4	-1.7	1.8
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.1	0.1	0.0	-0.0
Time to tail flick, test, before self-admin	1.3	1.3	1.4	-1.1	1.1	1.2	-1.1
Time to tail flick, test, after self-admin	0.3	0.3	0.3	-0.5	0.5	-0.5	0.6
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.9	0.5	-0.5	0.9	-0.9
Delta time to tail flick, test, before/after SA	0.3	0.3	0.5	0.3	-0.4	-0.7	0.7
Tibia length	3.6	9.9	19.8	-4.4	4.4	-0.2	0.5
Ambulatory time before self-admin	0.1	0.1	0.2	0.4	-0.4	-0.3	0.3
Ambulatory time after self-admin	0.4	0.4	0.5	0.7	-0.7	0.6	-0.7
Bone: tissue strength	0.2	0.2	0.4	-0.6	0.6	0.1	-0.1
Total heroin consumption	1.7	2.0	3.3	1.8	-1.8	-0.9	0.8
Bone: trabecular number	2.8	4.6	8.7	-3.0	3.0	0.7	-0.5
Bone: trabecular spacing	2.4	3.2	5.4	2.3	-2.3	-1.1	0.9
Bone: trabecular thickness	1.9	2.4	4.5	-2.1	2.1	0.6	-0.4
Bone: trabecular tissue density	0.3	0.4	0.8	-0.1	0.1	-0.9	0.9
Water consumed over 24 hours	1.3	1.8	2.3	-1.2	1.2	1.5	-1.4
Number of responses in last shaping day	0.3	0.4	0.6	0.4	-0.4	-0.8	0.8