Hub : Genes

LOC134481222

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression LOC134481222 0.02 0.01 6.9e-03 0.01 0 -0 0 2.6e-02 1.3e-01 3.8e-01 1.5e-01
2 NAcc isoform ratio XR_010056637.1 0.02 0.01 4.7e-03 0.01 0 0.01 0 2.8e-02 5.1e-02 4.2e-02 1.0e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density4.06.86.8-2.62.6
Area under the delay curve1.01.21.41.0-1.2
BMI with tail0.72.42.8-1.41.7
BMI without tail2.06.06.1-2.42.5
Body weight9.039.239.5-6.36.2
Weight adjusted by age0.50.81.1-0.71.1
Bone surface3.86.97.2-2.62.7
Bone volume1.12.12.2-1.41.5
Breakpoint value in progressive ratio session0.00.10.1-0.20.3
Number of licking bursts0.00.00.0-0.10.0
Context. condit. distance diff. score3.74.54.9-2.02.2
Locomotion velocity, session 10.30.30.40.4-0.6
Locomotion distance, session 11.21.51.61.2-1.3
Locomotion velocity, session 20.40.40.60.5-0.8
Locomotion distance, session 21.31.81.81.3-1.3
Locomotion velocity, session 30.40.40.7-0.80.4
Locomotion distance, session 30.10.10.2-0.50.2
Stereotopy head waving bouts, day 32.63.03.2-1.71.8
Stereotopy head waving duration, day 30.10.10.10.4-0.2
Locomotion velocity, session 71.31.41.61.1-1.3
Locomotion distance, session 70.40.50.60.7-0.8
Stereotopy head waving bouts, day 70.00.00.0-0.1-0.2
Stereotopy head waving duration, day 70.10.10.20.2-0.4
Locomotion velocity, session 80.20.20.4-0.60.2
Locomotion distance, session 80.60.91.1-0.81.1
Degree of sensitization distance1.41.41.71.3-1.1
Degree of sensitization stereotypy0.20.20.30.3-0.6
Conditioned locomotion0.00.00.10.3-0.1
Cocaine response after cond. corrected0.00.00.10.1-0.2
Cocaine response after cond. not corrected0.00.10.10.2-0.3
Cocaine response before conditioning0.00.00.1-0.20.2
Saline control response5.77.67.8-2.82.7
Bone: connectivity density7.311.411.7-3.33.4
Bone: cortical apparent density0.91.21.21.1-1.1
Bone: cortical area0.30.40.4-0.60.6
Bone: cortical porosity0.10.10.2-0.30.4
Bone: cortical porosity0.00.00.00.1-0.0
Bone: cortical thickness0.50.91.0-0.91.0
Bone: cortical thickness1.61.92.3-1.21.5
Bone: cortical tissue density0.91.21.21.1-1.1
Condit. Reinf. active minus inactive responses0.70.80.80.9-0.9
Condit. Reinf. active-inactive response ratio0.10.10.10.3-0.3
Condit. Reinf. active responses0.40.50.50.7-0.7
Condit. Reinf. inactive responses0.70.80.80.9-0.9
Incentive salience index mean0.81.01.11.0-1.0
Condit. Reinf. lever presses1.31.82.31.2-1.5
Condit. Reinf. active minus inactive responses1.62.02.1-1.41.5
Condit. Reinf. active-inactive response ratio0.40.40.5-0.70.6
Condit. Reinf. active responses1.52.12.4-1.41.5
Condit. Reinf. inactive responses0.60.81.0-0.71.0
Condit. Reinf. lever presses0.00.00.0-0.1-0.0
Condit. Reinf. lever reinforcers received0.60.80.9-0.81.0
Conditioned reinforcement - actives4.06.97.1-2.62.7
Conditioned reinforcement - inactives0.50.80.8-0.90.9
Conditioned locomotion4.25.46.6-2.12.6
Patch foraging indifference point 0 sec0.00.00.0-0.20.1
Patch foraging indifference point AUC1.01.51.6-1.21.2
Delay disc. indifference point, 0s delay0.20.20.30.3-0.6
Delay disc. indifference point, 16s delay0.10.10.10.3-0.2
Delay disc. indifference point, 2s delay2.52.83.31.8-1.5
Delay disc. indifference point, 24s delay0.80.91.00.9-1.0
Delay disc. indifference point, 4s delay1.81.92.31.2-1.5
Delay disc. indifference point, 8s delay0.40.40.60.5-0.8
Indifference point function ln k0.30.50.6-0.80.7
Indifference point function log k0.30.50.6-0.80.7
Patch foraging total patch changes 0 sec0.00.00.0-0.10.2
Patch foraging total patch changes 12 sec0.10.20.2-0.50.4
Patch foraging total patch changes 18 sec0.20.30.3-0.60.5
Patch foraging total patch changes 24 sec0.30.40.5-0.70.6
Patch foraging total patch changes 6 sec0.10.20.3-0.40.5
Patch foraging time to switch 0 sec2.65.35.62.4-2.2
Patch foraging water rate 0 sec4.49.49.7-3.03.1
Patch foraging water rate 12 sec0.81.72.1-1.51.1
Patch foraging water rate 18 sec0.00.00.1-0.00.3
Patch foraging water rate 24 sec3.24.55.2-2.32.0
Patch foraging water rate 6 sec1.31.92.2-1.51.2
Seeking ratio, delayed vs. immediate footshock1.21.41.81.0-1.3
Distance traveled before self-admin0.30.40.90.9-0.0
Distance traveled after self-admin0.10.10.2-0.10.5
Extensor digitorum longus weight4.718.619.9-4.24.5
Bone: elastic displacement0.60.70.8-0.90.8
Bone: elastic work4.35.65.8-2.42.3
Bone: endosteal estimation0.51.11.3-1.11.0
Bone: endosteal perimeter0.20.40.5-0.70.5
Epididymis fat weight0.00.10.20.1-0.5
Delta time in closed arm before/after self-admin0.10.10.1-0.40.3
Delta time in open arm before/after self-admin3.33.23.92.0-1.6
Diff in mean of infusions in LGA sessions0.30.40.6-0.80.4
Delay discount exponential model param1.61.81.9-1.31.4
Extinction: sum of active levers before priming0.30.40.50.5-0.7
Active lever presses in extinction session 60.20.20.2-0.40.4
Bone: final force0.91.41.4-1.21.2
Bone: final moment0.61.01.0-1.01.0
Food consumed during 24 hour testing period0.00.00.00.2-0.2
Glucose2.13.43.61.9-1.8
Heart weight0.81.21.8-0.81.3
Delay discount hyperbolic model param1.51.71.9-1.21.4
Intermittent access intake day 1-15 change1.22.62.6-1.61.6
Intermittent access intake escalation1.02.12.4-1.51.4
Intermittent access intake escalation 20.10.10.1-0.30.2
Intermitt. access day 1 inactive lever presses0.00.10.3-0.50.0
Intermitt. access day 15 inactive lever presses0.50.90.91.0-1.0
Intermitt. access escalation Index0.00.10.10.20.3
Intermittent access day 1 total infusions0.00.10.10.30.1
Intermittent access day 15 total infusions0.50.70.8-0.70.9
Intermittent access terminal intake (last 3 days)0.10.20.3-0.30.5
Intermittent access total infusions0.00.00.10.10.3
Intermittent access day 1 locomotion0.20.30.50.7-0.2
Intermittent access day 15 total locomotion0.81.42.0-0.91.4
Intermittent access total locomotion0.10.10.10.20.3
Intermittent access standard deviation0.10.10.2-0.10.5
Left kidney weight9.142.442.6-6.56.5
Right kidney weight5.926.827.0-5.15.2
Cocaine induced anxiety0.10.20.30.2-0.6
Post-drug Anxiety6.36.77.72.4-2.8
Baseline Anxiety5.15.96.12.5-2.4
Tail length6.625.826.6-5.25.0
Length with tail14.763.865.3-8.17.9
Length without tail8.527.527.9-5.35.2
Times rat made contact with spout0.20.20.3-0.50.4
Lifetime Intake0.10.10.20.5-0.1
Liver weight, left3.25.35.3-2.32.3
Liver weight, right2.03.53.8-2.01.8
Locomotor activity3.55.46.0-2.22.4
Locomotor testing distance1.93.54.1-1.72.0
Locomotor testing rearing0.51.11.3-1.01.1
Locomotion in novel chamber2.73.44.2-1.62.0
Locomotion in novel chamber post-restriction2.33.84.4-2.11.8
Fecal boli incidents, locomotor time 11.42.03.0-1.71.0
Change in fecal boli incidents, locomotor task0.40.40.50.7-0.5
Time >=10cm from walls, locomotor time 12.83.03.41.8-1.6
Bouts of movement, locomotor time 11.21.42.0-1.40.9
Total resting periods, locomotor time 11.11.31.7-1.30.9
Rest time, locomotor task time 10.91.11.3-1.11.0
Distance moved, locomotor task time 10.30.40.60.8-0.5
Vertical activity count, locomotor time 10.20.40.5-0.50.7
Time >=10cm from walls, locomotor time 20.00.00.00.1-0.1
Bouts of movement, locomotor time 20.91.42.2-1.50.8
Total resting periods, locomotor time 20.81.42.0-1.40.8
Rest time, locomotor task time 20.10.10.10.4-0.2
Distance moved, locomotor task time 20.10.10.1-0.20.3
Vertical activity count, locomotor time 21.52.12.5-1.61.3
Light reinforcement 10.82.12.71.6-1.2
Light reinforcement 20.00.10.10.1-0.3
Bone: marrow area0.51.01.2-1.10.9
Bone: maximum diameter0.30.50.6-0.80.7
Bone: maximum force0.71.21.2-1.11.1
Bone: maximum moment0.51.01.0-1.00.9
Mean time between licks in bursts0.41.11.11.0-1.0
Mean num. licks in bursts0.10.10.1-0.30.3
Cd content in liver0.20.20.3-0.50.4
Co content in liver4.04.64.9-2.22.1
Cu content in liver0.00.00.00.1-0.2
Fe content in liver0.00.10.1-0.30.2
K content in liver0.20.20.30.6-0.2
Mg content in liver0.10.10.2-0.10.4
Mn content in liver0.50.50.50.7-0.7
Na content in liver0.10.10.2-0.20.4
Rb content in liver5.05.86.12.3-2.5
Se content in liver0.10.20.2-0.50.3
Sr content in liver0.00.00.0-0.20.2
Zn content in liver6.26.96.9-2.62.6
Bone: minimum diameter0.61.01.11.0-1.0
Time in familiar zone, hab. session 10.60.50.70.8-0.6
Time in novel zone, hab. session 10.30.30.6-0.30.8
Total zone transitions, hab. session 12.23.03.31.8-1.7
Total locomotion distance, hab. session 11.42.02.81.7-1.1
Locomotion velocity, hab. session 12.02.93.01.7-1.7
Time in familiar zone, hab. session 20.00.00.10.1-0.2
Time in novel zone, hab. session 20.20.20.30.5-0.4
Total zone transitions, hab. session 20.00.00.00.20.0
Total locomotion distance, hab. session 20.40.60.80.9-0.5
Locomotion velocity, hab. session 20.50.71.01.0-0.5
Novel to familiar place preference ratio0.00.00.00.00.1
Novelty place preference0.10.10.20.4-0.3
Time in novel zone, NPP test0.00.00.00.2-0.1
Total zone transitions, NPP test0.10.10.20.5-0.3
Total locomotion distance, NPP test0.50.70.90.9-0.7
Locomotion velocity, NPP test0.30.40.60.7-0.5
Intraocular pressure1.11.61.7-1.31.2
Delta distance traveled before/after self-admin0.50.50.8-0.90.5
Delta ambulatory time before/after self-admin0.00.00.0-0.1-0.2
Parametrial fat weight0.10.10.20.10.5
Pavlov. Cond. lever latency4.35.55.9-2.22.4
Pavlov. Cond. magazine entry latency0.20.20.3-0.60.3
Pavlov. Cond. change in total contacts1.92.12.61.2-1.6
Pavlov. Cond. index score0.40.50.70.5-0.9
Pavlov. Cond. latency score1.01.31.70.9-1.3
Pavlov. Cond. lever contacts4.14.95.42.1-2.3
Pavlov. Cond. magazine entry number0.10.20.30.5-0.2
Pavlov. Cond. intertrial magazine entries0.30.40.60.8-0.5
Pavlov. Cond. lever-magazine prob. diff.0.40.50.80.4-0.9
Pavlov. Cond. response bias0.00.00.10.1-0.3
Pavlov. Cond. lever latency0.40.60.7-0.70.9
Pavlov. Cond. magazine entry latency2.02.42.91.4-1.7
Pavlov. Cond. change in total contacts0.10.10.20.2-0.4
Pavlov. Cond. index score1.31.82.21.2-1.5
Pavlov. Cond. latency score1.11.51.81.1-1.4
Pavlov. Cond. lever contacts0.60.81.00.8-1.0
Pavlov. Cond. magazine entry number1.01.31.6-0.91.3
Pavlov. Cond. intertrial magazine entries0.30.40.5-0.50.7
Pavlov. Cond. lever-magazine prob. diff.1.41.82.21.2-1.5
Pavlov. Cond. response bias1.01.31.61.0-1.3
Time in closed arm before self-admin3.24.14.3-2.02.1
Time in closed arm after self-admin3.63.83.9-1.92.0
Time in open arm before self-admin0.00.10.10.1-0.3
Time in open arm after self-admin2.22.52.71.6-1.5
Bone: periosteal estimation0.51.01.1-1.00.9
Bone: periosteal perimeter0.00.00.0-0.20.1
Bone: post-yield work0.20.40.4-0.60.6
Progressive ratio test 1 active lever presses2.02.52.8-1.51.7
Progressive ratio test 1 breakpoint1.92.42.7-1.41.6
Progressive ratio test 1 inactive lever presses1.82.62.9-1.51.7
Progressive ratio test 2 active lever presses2.22.62.7-1.61.6
Progressive ratio test 2 breakpoint2.02.32.3-1.51.5
Progressive ratio test 2 inactive lever presses4.06.46.9-2.42.6
Incentive Sensitization - Responses0.00.00.0-0.10.1
Incentive Sensitization - Breakpoint0.00.00.0-0.00.1
Sum of active levers in priming session hrs 5-60.20.20.20.4-0.5
Progressive ratio0.71.11.40.9-1.2
Food seeking constrained by brief footshock1.01.21.51.0-1.2
Seeking ratio, punishment vs. effort0.50.80.8-0.90.9
Retroperitoneal fat weight0.31.21.31.2-1.0
Reaction time number correct1.01.92.5-1.61.2
Reaction time mean minus median0.00.00.00.0-0.1
Reaction time mean minus median AUC0.00.10.10.4-0.3
Reaction time num false alarms0.00.00.0-0.0-0.1
Reaction time num false alarms AUC0.00.00.1-0.20.2
Reaction time trials correct on left1.01.92.5-1.61.2
Reaction time trials on left1.01.82.4-1.61.1
Reaction time mean1.62.52.51.6-1.6
Reaction time mean AUC1.32.02.01.4-1.4
Median of all reaction times2.73.83.81.9-2.0
Reaction time omissions0.30.50.50.7-0.7
Reaction time false alarm rate0.10.10.20.5-0.2
Reaction time premature initiation rate0.30.40.60.8-0.4
Reaction time premature initiations0.00.00.00.00.1
Std. dev. reaction times0.51.01.01.0-0.9
Reaction time trials completed1.01.82.4-1.61.1
Reaction time trials AUC0.71.41.9-1.41.0
Run reversals in cocaine runway, females0.80.81.00.8-1.0
Run reversals in cocaine runway, males0.10.10.2-0.40.1
Latency to leave start box in cocaine runway0.40.40.50.6-0.7
Latency to leave start box in cocaine runway, F0.00.00.1-0.0-0.2
Latency to leave start box in cocaine runway, M0.30.30.40.6-0.5
Std. dev. time between licks in bursts0.50.70.8-0.90.8
Total sessions with >9 infusions0.10.10.20.50.1
Short access day 1 total inactive lever presses0.10.20.2-0.40.3
Short access day 10 total inactive lever presses0.51.31.6-1.21.0
Short access day 1 total infusions0.81.01.41.2-0.8
Short access day 10 total infusions0.10.20.30.6-0.1
Short access total infusions0.81.01.61.3-0.7
Short access day 1 locomotion0.00.00.10.3-0.1
Short access day 10 total locomotion0.00.00.1-0.10.3
Short access total locomotion0.40.50.80.9-0.5
One hour access (0.3 mA shock)2.83.23.4-1.81.8
Compulsive drug intake3.13.74.61.6-2.2
One hour access (shock baseline)3.55.46.2-2.12.5
Social response proportion4.85.45.6-2.42.3
Social responses3.74.74.8-2.22.2
Social time2.53.44.31.6-2.1
Soleus weight1.64.84.9-2.22.2
Bone: stiffness0.10.10.1-0.40.4
Tibialis anterior weight5.016.917.5-4.24.0
Time to tail flick, vehicle, before self-admin2.02.12.51.3-1.6
Time to tail flick, vehicle, after self-admin0.00.00.0-0.2-0.2
Time to tail flick, test, before self-admin2.32.42.8-1.41.7
Time to tail flick, test, after self-admin0.40.40.70.9-0.4
Delta time to tail flick, vehicle, before/after SA0.20.20.3-0.30.5
Delta time to tail flick, test, before/after SA2.12.22.31.5-1.4
Tibia length2.77.37.5-2.72.7
Ambulatory time before self-admin0.10.20.20.40.5
Ambulatory time after self-admin0.10.10.10.20.3
Bone: tissue strength0.20.20.2-0.40.4
Total heroin consumption2.22.62.81.7-1.5
Bone: trabecular number4.27.07.1-2.72.6
Bone: trabecular spacing4.56.06.02.4-2.4
Bone: trabecular thickness3.34.14.3-2.12.0
Bone: trabecular tissue density0.20.30.30.4-0.6
Water consumed over 24 hours1.72.22.5-1.61.4
Number of responses in last shaping day0.30.30.40.6-0.5