Hub : Genes

LOC134481222

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression LOC134481222 0.02 0.01 6.9e-03 0.01 0 -0 0 2.6e-02 1.3e-01 3.8e-01 1.6e-01
2 NAcc isoform ratio XR_010056637.1 0.02 0.01 4.7e-03 0.01 0 0 0 2.8e-02 5.1e-02 4.3e-02 9.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density3.76.86.82.6-2.6
Area under the delay curve0.81.21.4-1.01.2
BMI with tail0.72.42.81.4-1.7
BMI without tail1.16.06.12.4-2.5
Body weight9.039.239.56.3-6.2
Weight adjusted by age0.30.81.10.7-1.1
Bone surface3.56.97.22.6-2.7
Bone volume1.02.12.21.4-1.5
Breakpoint value in progressive ratio session0.00.10.10.2-0.3
Number of licking bursts0.00.00.00.1-0.0
Context. condit. distance diff. score3.74.54.92.0-2.2
Locomotion velocity, session 10.20.30.4-0.40.6
Locomotion distance, session 11.21.51.6-1.21.3
Locomotion velocity, session 20.30.40.6-0.50.8
Locomotion distance, session 21.31.81.8-1.31.3
Locomotion velocity, session 30.40.40.70.8-0.4
Locomotion distance, session 30.10.10.20.5-0.2
Stereotopy head waving bouts, day 32.53.03.21.7-1.8
Stereotopy head waving duration, day 30.10.10.1-0.40.2
Locomotion velocity, session 71.31.41.6-1.11.3
Locomotion distance, session 70.40.50.6-0.70.8
Stereotopy head waving bouts, day 70.00.00.00.10.2
Stereotopy head waving duration, day 70.10.10.2-0.20.4
Locomotion velocity, session 80.20.20.40.6-0.2
Locomotion distance, session 80.60.91.10.8-1.1
Degree of sensitization distance1.31.41.7-1.31.1
Degree of sensitization stereotypy0.20.20.3-0.30.6
Conditioned locomotion0.00.00.1-0.30.1
Cocaine response after cond. corrected0.00.00.1-0.10.2
Cocaine response after cond. not corrected0.00.10.1-0.20.3
Cocaine response before conditioning0.00.00.10.2-0.2
Saline control response5.57.67.82.8-2.7
Bone: connectivity density7.111.411.73.3-3.4
Bone: cortical apparent density0.81.21.2-1.11.1
Bone: cortical area0.20.40.40.6-0.6
Bone: cortical porosity0.10.10.20.3-0.4
Bone: cortical porosity0.00.00.0-0.10.0
Bone: cortical thickness0.50.91.00.9-1.0
Bone: cortical thickness1.61.92.31.2-1.5
Bone: cortical tissue density0.81.21.2-1.11.1
Condit. Reinf. active minus inactive responses0.70.80.8-0.90.9
Condit. Reinf. active-inactive response ratio0.10.10.1-0.30.3
Condit. Reinf. active responses0.40.50.5-0.70.7
Condit. Reinf. inactive responses0.60.80.8-0.90.9
Incentive salience index mean0.81.01.1-1.01.0
Condit. Reinf. lever presses1.21.82.3-1.21.5
Condit. Reinf. active minus inactive responses1.32.02.11.4-1.5
Condit. Reinf. active-inactive response ratio0.30.40.50.7-0.6
Condit. Reinf. active responses1.52.12.41.4-1.5
Condit. Reinf. inactive responses0.50.81.00.7-1.0
Condit. Reinf. lever presses0.00.00.00.10.0
Condit. Reinf. lever reinforcers received0.60.80.90.8-1.0
Conditioned reinforcement - actives1.76.97.12.6-2.7
Conditioned reinforcement - inactives0.30.80.80.9-0.9
Conditioned locomotion3.75.46.62.1-2.6
Patch foraging indifference point 0 sec0.00.00.00.2-0.1
Patch foraging indifference point AUC0.61.51.61.2-1.2
Delay disc. indifference point, 0s delay0.20.20.3-0.30.6
Delay disc. indifference point, 16s delay0.00.10.1-0.30.2
Delay disc. indifference point, 2s delay2.52.83.3-1.81.5
Delay disc. indifference point, 24s delay0.50.91.0-0.91.0
Delay disc. indifference point, 4s delay1.81.92.3-1.21.5
Delay disc. indifference point, 8s delay0.20.40.6-0.50.8
Indifference point function ln k0.20.50.60.8-0.7
Indifference point function log k0.20.50.60.8-0.7
Patch foraging total patch changes 0 sec0.00.00.00.1-0.2
Patch foraging total patch changes 12 sec0.10.20.20.5-0.4
Patch foraging total patch changes 18 sec0.10.30.30.6-0.5
Patch foraging total patch changes 24 sec0.10.40.50.7-0.6
Patch foraging total patch changes 6 sec0.10.20.30.4-0.5
Patch foraging time to switch 0 sec1.45.35.6-2.42.2
Patch foraging water rate 0 sec2.59.49.73.0-3.1
Patch foraging water rate 12 sec0.41.72.11.5-1.1
Patch foraging water rate 18 sec0.00.00.10.0-0.3
Patch foraging water rate 24 sec3.24.55.22.3-2.0
Patch foraging water rate 6 sec1.31.92.21.5-1.2
Seeking ratio, delayed vs. immediate footshock1.01.41.8-1.01.3
Distance traveled before self-admin0.20.40.9-0.90.0
Distance traveled after self-admin0.10.10.20.1-0.5
Extensor digitorum longus weight4.718.619.94.2-4.5
Bone: elastic displacement0.50.70.80.9-0.8
Bone: elastic work4.35.65.82.4-2.3
Bone: endosteal estimation0.51.11.31.1-1.0
Bone: endosteal perimeter0.20.40.50.7-0.5
Epididymis fat weight0.00.10.2-0.10.5
Delta time in closed arm before/after self-admin0.10.10.10.4-0.3
Delta time in open arm before/after self-admin2.73.23.9-2.01.6
Diff in mean of infusions in LGA sessions0.20.40.60.8-0.4
Delay discount exponential model param1.31.81.91.3-1.4
Extinction: sum of active levers before priming0.20.40.5-0.50.7
Active lever presses in extinction session 60.20.20.20.4-0.4
Bone: final force0.91.41.41.2-1.2
Bone: final moment0.61.01.01.0-1.0
Food consumed during 24 hour testing period0.00.00.0-0.20.2
Glucose2.13.43.6-1.91.8
Heart weight0.81.21.80.8-1.3
Delay discount hyperbolic model param1.31.71.91.2-1.4
Intermittent access intake day 1-15 change0.52.62.61.6-1.6
Intermittent access intake escalation0.42.12.41.5-1.4
Intermittent access intake escalation 20.00.10.10.3-0.2
Intermitt. access day 1 inactive lever presses0.00.10.30.5-0.0
Intermitt. access day 15 inactive lever presses0.20.90.9-1.01.0
Intermitt. access escalation Index0.00.10.1-0.2-0.3
Intermittent access day 1 total infusions0.00.10.1-0.3-0.1
Intermittent access day 15 total infusions0.30.70.80.7-0.9
Intermittent access terminal intake (last 3 days)0.10.20.30.3-0.5
Intermittent access total infusions0.00.00.1-0.1-0.3
Intermittent access day 1 locomotion0.20.30.5-0.70.2
Intermittent access day 15 total locomotion0.41.42.00.9-1.4
Intermittent access total locomotion0.10.10.1-0.2-0.3
Intermittent access standard deviation0.00.10.20.1-0.5
Left kidney weight5.342.442.66.5-6.5
Right kidney weight3.826.827.05.1-5.2
Cocaine induced anxiety0.10.20.3-0.20.6
Post-drug Anxiety5.96.77.7-2.42.8
Baseline Anxiety3.55.96.1-2.52.4
Tail length4.825.826.65.2-5.0
Length with tail14.463.865.38.1-7.9
Length without tail5.227.527.95.3-5.2
Times rat made contact with spout0.20.20.30.5-0.4
Lifetime Intake0.10.10.2-0.50.1
Liver weight, left3.05.35.32.3-2.3
Liver weight, right2.03.53.82.0-1.8
Locomotor activity3.55.46.02.2-2.4
Locomotor testing distance1.43.54.11.7-2.0
Locomotor testing rearing0.31.11.31.0-1.1
Locomotion in novel chamber2.63.44.21.6-2.0
Locomotion in novel chamber post-restriction1.33.84.42.1-1.8
Fecal boli incidents, locomotor time 10.82.03.01.7-1.0
Change in fecal boli incidents, locomotor task0.40.40.5-0.70.5
Time >=10cm from walls, locomotor time 12.43.03.4-1.81.6
Bouts of movement, locomotor time 11.11.42.01.4-0.9
Total resting periods, locomotor time 11.11.31.71.3-0.9
Rest time, locomotor task time 10.71.11.31.1-1.0
Distance moved, locomotor task time 10.10.40.6-0.80.5
Vertical activity count, locomotor time 10.10.40.50.5-0.7
Time >=10cm from walls, locomotor time 20.00.00.0-0.10.1
Bouts of movement, locomotor time 20.41.42.21.5-0.8
Total resting periods, locomotor time 20.31.42.01.4-0.8
Rest time, locomotor task time 20.10.10.1-0.40.2
Distance moved, locomotor task time 20.10.10.10.2-0.3
Vertical activity count, locomotor time 20.92.12.51.6-1.3
Light reinforcement 10.52.12.7-1.61.2
Light reinforcement 20.00.10.1-0.10.3
Bone: marrow area0.41.01.21.1-0.9
Bone: maximum diameter0.30.50.60.8-0.7
Bone: maximum force0.61.21.21.1-1.1
Bone: maximum moment0.51.01.01.0-0.9
Mean time between licks in bursts0.21.11.1-1.01.0
Mean num. licks in bursts0.00.10.10.3-0.3
Cd content in liver0.20.20.30.5-0.4
Co content in liver3.94.64.92.2-2.1
Cu content in liver0.00.00.0-0.10.2
Fe content in liver0.00.10.10.3-0.2
K content in liver0.20.20.3-0.60.2
Mg content in liver0.10.10.20.1-0.4
Mn content in liver0.50.50.5-0.70.7
Na content in liver0.10.10.20.2-0.4
Rb content in liver5.05.86.1-2.32.5
Se content in liver0.10.20.20.5-0.3
Sr content in liver0.00.00.00.2-0.2
Zn content in liver5.96.96.92.6-2.6
Bone: minimum diameter0.51.01.1-1.01.0
Time in familiar zone, hab. session 10.50.50.7-0.80.6
Time in novel zone, hab. session 10.30.30.60.3-0.8
Total zone transitions, hab. session 12.23.03.3-1.81.7
Total locomotion distance, hab. session 11.42.02.8-1.71.1
Locomotion velocity, hab. session 12.02.93.0-1.71.7
Time in familiar zone, hab. session 20.00.00.1-0.10.2
Time in novel zone, hab. session 20.20.20.3-0.50.4
Total zone transitions, hab. session 20.00.00.0-0.2-0.0
Total locomotion distance, hab. session 20.40.60.8-0.90.5
Locomotion velocity, hab. session 20.50.71.0-1.00.5
Novel to familiar place preference ratio0.00.00.0-0.0-0.1
Novelty place preference0.10.10.2-0.40.3
Time in novel zone, NPP test0.00.00.0-0.20.1
Total zone transitions, NPP test0.10.10.2-0.50.3
Total locomotion distance, NPP test0.50.70.9-0.90.7
Locomotion velocity, NPP test0.30.40.6-0.70.5
Intraocular pressure1.01.61.71.3-1.2
Delta distance traveled before/after self-admin0.50.50.80.9-0.5
Delta ambulatory time before/after self-admin0.00.00.00.10.2
Parametrial fat weight0.10.10.2-0.1-0.5
Pavlov. Cond. lever latency4.35.55.92.2-2.4
Pavlov. Cond. magazine entry latency0.20.20.30.6-0.3
Pavlov. Cond. change in total contacts1.92.12.6-1.21.6
Pavlov. Cond. index score0.40.50.7-0.50.9
Pavlov. Cond. latency score1.01.31.7-0.91.3
Pavlov. Cond. lever contacts4.04.95.4-2.12.3
Pavlov. Cond. magazine entry number0.10.20.3-0.50.2
Pavlov. Cond. intertrial magazine entries0.30.40.6-0.80.5
Pavlov. Cond. lever-magazine prob. diff.0.40.50.8-0.40.9
Pavlov. Cond. response bias0.00.00.1-0.10.3
Pavlov. Cond. lever latency0.40.60.70.7-0.9
Pavlov. Cond. magazine entry latency1.72.42.9-1.41.7
Pavlov. Cond. change in total contacts0.00.10.2-0.20.4
Pavlov. Cond. index score1.11.82.2-1.21.5
Pavlov. Cond. latency score0.91.51.8-1.11.4
Pavlov. Cond. lever contacts0.50.81.0-0.81.0
Pavlov. Cond. magazine entry number1.01.31.60.9-1.3
Pavlov. Cond. intertrial magazine entries0.20.40.50.5-0.7
Pavlov. Cond. lever-magazine prob. diff.1.21.82.2-1.21.5
Pavlov. Cond. response bias1.01.31.6-1.01.3
Time in closed arm before self-admin2.44.14.32.0-2.1
Time in closed arm after self-admin3.43.83.91.9-2.0
Time in open arm before self-admin0.00.10.1-0.10.3
Time in open arm after self-admin2.22.52.7-1.61.5
Bone: periosteal estimation0.41.01.11.0-0.9
Bone: periosteal perimeter0.00.00.00.2-0.1
Bone: post-yield work0.20.40.40.6-0.6
Progressive ratio test 1 active lever presses1.42.52.81.5-1.7
Progressive ratio test 1 breakpoint1.42.42.71.4-1.6
Progressive ratio test 1 inactive lever presses1.02.62.91.5-1.7
Progressive ratio test 2 active lever presses1.82.62.71.6-1.6
Progressive ratio test 2 breakpoint1.82.32.31.5-1.5
Progressive ratio test 2 inactive lever presses2.06.46.92.4-2.6
Incentive Sensitization - Responses0.00.00.00.1-0.1
Incentive Sensitization - Breakpoint0.00.00.00.0-0.1
Sum of active levers in priming session hrs 5-60.20.20.2-0.40.5
Progressive ratio0.41.11.4-0.91.2
Food seeking constrained by brief footshock1.01.21.5-1.01.2
Seeking ratio, punishment vs. effort0.40.80.80.9-0.9
Retroperitoneal fat weight0.31.21.3-1.21.0
Reaction time number correct0.51.92.51.6-1.2
Reaction time mean minus median0.00.00.0-0.00.1
Reaction time mean minus median AUC0.00.10.1-0.40.3
Reaction time num false alarms0.00.00.00.00.1
Reaction time num false alarms AUC0.00.00.10.2-0.2
Reaction time trials correct on left0.51.92.51.6-1.2
Reaction time trials on left0.51.82.41.6-1.1
Reaction time mean1.12.52.5-1.61.6
Reaction time mean AUC0.82.02.0-1.41.4
Median of all reaction times2.43.83.8-1.92.0
Reaction time omissions0.30.50.5-0.70.7
Reaction time false alarm rate0.10.10.2-0.50.2
Reaction time premature initiation rate0.20.40.6-0.80.4
Reaction time premature initiations0.00.00.0-0.0-0.1
Std. dev. reaction times0.31.01.0-1.00.9
Reaction time trials completed0.51.82.41.6-1.1
Reaction time trials AUC0.41.41.91.4-1.0
Run reversals in cocaine runway, females0.70.81.0-0.81.0
Run reversals in cocaine runway, males0.10.10.20.4-0.1
Latency to leave start box in cocaine runway0.30.40.5-0.60.7
Latency to leave start box in cocaine runway, F0.00.00.10.00.2
Latency to leave start box in cocaine runway, M0.30.30.4-0.60.5
Std. dev. time between licks in bursts0.40.70.80.9-0.8
Total sessions with >9 infusions0.10.10.2-0.5-0.1
Short access day 1 total inactive lever presses0.10.20.20.4-0.3
Short access day 10 total inactive lever presses0.21.31.61.2-1.0
Short access day 1 total infusions0.51.01.4-1.20.8
Short access day 10 total infusions0.10.20.3-0.60.1
Short access total infusions0.71.01.6-1.30.7
Short access day 1 locomotion0.00.00.1-0.30.1
Short access day 10 total locomotion0.00.00.10.1-0.3
Short access total locomotion0.30.50.8-0.90.5
One hour access (0.3 mA shock)2.73.23.41.8-1.8
Compulsive drug intake2.53.74.6-1.62.2
One hour access (shock baseline)2.15.46.22.1-2.5
Social response proportion4.35.45.62.4-2.3
Social responses3.64.74.82.2-2.2
Social time2.23.44.3-1.62.1
Soleus weight1.64.84.92.2-2.2
Bone: stiffness0.10.10.10.4-0.4
Tibialis anterior weight4.916.917.54.2-4.0
Time to tail flick, vehicle, before self-admin1.72.12.5-1.31.6
Time to tail flick, vehicle, after self-admin0.00.00.00.20.2
Time to tail flick, test, before self-admin2.02.42.81.4-1.7
Time to tail flick, test, after self-admin0.40.40.7-0.90.4
Delta time to tail flick, vehicle, before/after SA0.20.20.30.3-0.5
Delta time to tail flick, test, before/after SA1.82.22.3-1.51.4
Tibia length2.67.37.52.7-2.7
Ambulatory time before self-admin0.10.20.2-0.4-0.5
Ambulatory time after self-admin0.00.10.1-0.2-0.3
Bone: tissue strength0.20.20.20.4-0.4
Total heroin consumption2.22.62.8-1.71.5
Bone: trabecular number3.77.07.12.7-2.6
Bone: trabecular spacing4.16.06.0-2.42.4
Bone: trabecular thickness2.94.14.32.1-2.0
Bone: trabecular tissue density0.20.30.3-0.40.6
Water consumed over 24 hours1.22.22.51.6-1.4
Number of responses in last shaping day0.30.30.4-0.60.5