LOC134481148

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	LOC134481148	0.08	0.05	1.6e-03	0.07	0.05	0.04	0.04	1.9e-04	1.9e-03	3.2e-03	3.0e-03
2	PL	gene expression	LOC134481148	0.14	0.06	1.0e-11	0.09	0.12	0.1	0.11	1.5e-09	1.3e-12	1.9e-11	2.3e-12
3	Adipose	gene expression	LOC134481148	0.13	0.07	7.8e-05	0.04	0.02	0.03	0.03	2.8e-05	1.7e-03	1.1e-04	1.6e-04
4	Brain	gene expression	LOC134481148	0.11	0.06	1.7e-03	0.05	0.03	0.03	0.01	3.0e-05	8.9e-04	3.8e-04	1.4e-02
5	NAcc	gene expression	LOC134481148	0.03	0.02	1.5e-03	0.01	0.01	0.01	0.01	2.9e-03	5.9e-03	2.2e-03	3.1e-03
6	IC	gene expression	LOC134481148	0.09	0.07	3.8e-03	0.02	0.03	-0	0.01	3.6e-02	1.4e-02	4.3e-01	9.2e-02
7	NAcc	intron excision ratio	chr12_11033285_11034241	0.01	0.01	3.9e-03	0.01	0.01	0.01	0	1.6e-02	7.0e-03	4.0e-02	6.7e-02
8	NAcc	intron excision ratio	chr12_11033285_11034497	0.02	0.01	5.4e-05	0.02	0.02	0.01	0.02	1.5e-03	2.0e-04	5.8e-03	1.5e-03
9	PL	intron excision ratio	chr12_11033285_11034497	0.04	0.03	6.9e-03	0.02	0.02	0.01	0.02	4.1e-03	5.3e-03	3.0e-02	5.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	5.2	8.9	16.1	4.0	3.6	3.2	2.9	3.3	2.5	-2.3	-2.5	-2.0
Area under the delay curve	1.1	1.2	2.2	-1.2	-1.1	-1.5	-1.5	-1.2	-0.9	0.8	0.6	0.9
BMI with tail	2.4	8.4	10.8	3.0	2.9	2.6	2.6	3.3	3.1	-3.0	-3.1	-2.5
BMI without tail	0.1	0.4	1.1	0.2	0.6	-0.3	-0.2	-0.4	-1.0	0.9	0.5	1.0
Body weight	4.0	17.6	44.1	6.2	6.6	4.7	4.6	4.2	2.3	-2.0	-2.4	-0.6
Weight adjusted by age	0.1	0.1	0.5	0.5	-0.1	0.3	0.0	0.1	0.0	0.1	0.3	0.7
Bone surface	2.5	4.5	10.6	3.3	3.0	2.0	1.9	2.2	1.6	-1.6	-1.8	-0.6
Bone volume	3.9	7.0	12.6	3.5	3.2	2.3	2.0	2.8	2.5	-2.5	-2.8	-1.6
Breakpoint value in progressive ratio session	0.6	0.8	1.7	-0.3	0.1	-0.8	-0.5	-0.8	-1.2	1.1	0.8	1.3
Number of licking bursts	0.4	0.6	1.3	1.2	1.0	1.0	1.1	0.8	-0.1	0.3	0.3	-0.2
Context. condit. distance diff. score	0.4	0.5	0.9	0.7	0.9	-0.4	-0.4	-0.1	0.6	-0.8	-0.9	0.9
Locomotion velocity, session 1	0.3	0.3	0.7	-0.3	-0.4	-0.1	-0.1	-0.5	-0.6	0.7	0.8	0.8
Locomotion distance, session 1	0.2	0.3	1.0	-0.2	-0.7	0.1	0.3	-0.1	-0.7	0.9	1.0	0.2
Locomotion velocity, session 2	0.4	0.5	1.3	0.7	0.3	1.1	1.1	0.7	-0.3	0.5	0.6	-0.2
Locomotion distance, session 2	1.1	1.5	4.3	-0.2	-0.4	0.2	0.1	-0.6	-1.8	2.0	2.1	1.0
Locomotion velocity, session 3	0.3	0.3	0.8	0.5	0.6	0.2	0.2	0.5	0.8	-0.9	-0.9	0.0
Locomotion distance, session 3	0.4	0.4	0.8	-0.5	-0.0	-0.2	-0.1	-0.6	-0.9	0.9	0.8	0.9
Stereotopy head waving bouts, day 3	0.3	0.3	2.0	0.6	0.2	-0.0	-0.1	-0.3	-0.3	0.3	0.5	1.4
Stereotopy head waving duration, day 3	0.4	0.5	1.0	-0.4	-0.8	-0.9	-0.9	-0.7	0.3	-0.4	-0.2	1.0
Locomotion velocity, session 7	2.4	2.6	5.9	-1.7	-1.5	-2.4	-2.4	-2.0	-0.7	0.4	0.2	1.7
Locomotion distance, session 7	3.2	4.0	7.5	-2.1	-1.7	-2.7	-2.7	-2.4	-1.4	1.0	0.8	2.1
Stereotopy head waving bouts, day 7	2.8	3.2	4.8	-1.6	-1.3	-1.2	-1.4	-2.0	-2.2	2.2	2.1	1.7
Stereotopy head waving duration, day 7	0.6	0.7	1.4	-0.8	-0.7	-0.3	-0.3	-0.8	-1.0	1.1	1.2	0.8
Locomotion velocity, session 8	0.5	0.6	1.5	-0.4	-0.6	-0.3	-0.2	-0.6	-1.0	1.1	1.2	0.9
Locomotion distance, session 8	0.3	0.4	1.3	0.7	0.7	0.2	0.1	-0.2	-0.6	0.6	0.6	1.1
Degree of sensitization distance	1.5	1.5	3.6	-1.2	-1.4	-1.8	-1.9	-1.4	-0.6	0.4	0.3	0.9
Degree of sensitization stereotypy	0.5	0.6	1.0	-0.8	-0.6	-0.4	-0.5	-0.8	-1.0	1.0	1.0	0.4
Conditioned locomotion	0.3	0.3	1.0	-0.7	-1.0	-0.4	-0.3	-0.6	-0.4	0.4	0.6	0.5
Cocaine response after cond. corrected	0.4	0.5	2.1	-0.0	-0.0	-0.0	0.0	0.6	0.7	-0.8	-0.9	-1.4
Cocaine response after cond. not corrected	0.5	0.6	2.2	0.1	0.2	0.1	0.0	0.7	0.8	-0.9	-1.0	-1.5
Cocaine response before conditioning	0.1	0.1	0.2	0.0	0.3	-0.3	-0.4	-0.3	-0.2	0.2	0.0	0.4
Saline control response	2.4	3.2	6.2	-1.1	-0.8	-0.7	-0.8	-1.8	-2.3	2.4	2.5	2.3
Bone: connectivity density	1.9	3.0	7.9	2.8	2.7	1.9	1.9	1.7	0.9	-0.8	-0.9	0.1
Bone: cortical apparent density	0.8	1.1	1.7	0.6	0.5	1.3	1.2	1.2	1.2	-1.1	-0.9	-1.2
Bone: cortical area	0.9	1.4	3.5	1.9	1.9	0.8	0.7	1.1	0.9	-1.0	-1.2	-0.2
Bone: cortical porosity	0.5	0.5	1.2	-0.5	-1.1	-0.7	-0.7	-0.7	-0.7	0.7	0.8	0.4
Bone: cortical porosity	1.0	1.1	2.1	-0.9	-1.5	-1.1	-1.2	-1.1	-0.9	0.8	0.9	0.8
Bone: cortical thickness	1.1	1.7	3.1	1.8	1.7	1.3	1.2	1.3	1.2	-1.2	-1.3	-0.7
Bone: cortical thickness	1.5	1.8	2.8	-1.7	-1.2	-1.0	-1.1	-1.6	-1.4	1.4	1.3	1.3
Bone: cortical tissue density	0.8	1.1	1.7	0.6	0.4	1.3	1.2	1.2	1.2	-1.1	-0.8	-1.2
Condit. Reinf. active minus inactive responses	1.2	1.4	2.1	1.3	1.0	1.1	1.1	1.3	1.5	-1.4	-1.2	-0.5
Condit. Reinf. active-inactive response ratio	1.3	1.4	3.4	0.8	0.4	0.6	0.6	1.0	1.8	-1.9	-1.6	-0.9
Condit. Reinf. active responses	0.6	0.7	1.1	1.0	0.7	0.9	0.9	1.0	0.9	-0.8	-0.6	-0.5
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.2	-0.4	-0.3	-0.3	-0.3	-0.5	0.6	0.5	0.2
Incentive salience index mean	0.2	0.2	0.3	0.6	0.6	0.3	0.4	0.5	0.5	-0.5	-0.5	-0.3
Condit. Reinf. lever presses	0.1	0.2	0.5	-0.3	-0.5	-0.7	-0.6	-0.2	-0.0	-0.1	-0.2	-0.3
Condit. Reinf. active minus inactive responses	1.4	1.8	3.2	-1.3	-0.9	-0.9	-0.8	-1.5	-1.5	1.5	1.5	1.8
Condit. Reinf. active-inactive response ratio	1.8	2.1	3.3	-1.4	-1.1	-1.0	-1.1	-1.6	-1.6	1.6	1.6	1.8
Condit. Reinf. active responses	0.9	1.3	2.3	-0.8	-0.4	-0.4	-0.5	-1.1	-1.5	1.5	1.5	1.5
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.2	0.4	0.3	0.2	-0.1	-0.5	0.6	0.6	0.1
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.2	0.3	-0.4	-0.5	-0.4	-0.4	0.3	0.1	0.4
Condit. Reinf. lever reinforcers received	0.8	1.1	2.1	-0.7	-0.3	-0.4	-0.4	-1.0	-1.4	1.5	1.4	1.4
Conditioned reinforcement - actives	0.8	1.4	3.1	1.6	1.7	1.8	1.6	1.1	-0.0	0.2	0.2	0.1
Conditioned reinforcement - inactives	1.0	1.5	3.1	1.4	1.6	1.8	1.5	1.3	0.5	-0.4	-0.4	-0.8
Conditioned locomotion	0.2	0.2	0.5	0.6	0.7	0.5	0.7	0.3	-0.3	0.4	0.3	-0.2
Patch foraging indifference point 0 sec	0.8	1.5	2.3	1.5	1.5	1.4	1.2	1.3	1.1	-1.0	-1.0	-0.9
Patch foraging indifference point AUC	0.0	0.1	0.1	0.2	0.2	0.2	0.3	0.3	0.3	-0.3	-0.3	-0.1
Delay disc. indifference point, 0s delay	0.0	0.0	0.2	0.0	0.2	-0.1	-0.1	-0.1	-0.0	-0.1	-0.2	0.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.5	-0.3	-0.3	-0.7	-0.5	-0.2	0.2	-0.3	-0.5	0.1
Delay disc. indifference point, 2s delay	2.4	2.7	4.1	-1.9	-1.4	-1.9	-2.0	-1.8	-1.6	1.5	1.2	1.1
Delay disc. indifference point, 24s delay	0.4	0.4	1.0	-0.7	-0.8	-1.0	-1.0	-0.6	-0.1	-0.0	-0.2	0.6
Delay disc. indifference point, 4s delay	0.3	0.3	1.1	-0.5	-0.7	-0.9	-1.1	-0.4	-0.1	-0.1	-0.2	0.1
Delay disc. indifference point, 8s delay	0.6	0.7	1.1	-1.1	-1.0	-1.0	-1.0	-0.9	-0.8	0.7	0.7	0.5
Indifference point function ln k	0.3	0.5	1.1	0.8	0.8	1.1	1.0	0.5	-0.1	0.3	0.4	0.0
Indifference point function log k	0.3	0.5	1.1	0.8	0.8	1.1	1.0	0.5	-0.1	0.3	0.4	0.0
Patch foraging total patch changes 0 sec	0.5	1.0	1.6	1.3	1.2	1.1	0.9	1.0	0.9	-0.9	-0.8	-0.5
Patch foraging total patch changes 12 sec	1.7	2.2	2.6	1.3	1.4	1.4	1.4	1.6	1.6	-1.6	-1.6	-1.3
Patch foraging total patch changes 18 sec	0.5	0.8	1.9	0.5	0.0	0.5	0.5	0.8	1.4	-1.4	-1.2	-0.7
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.2	0.3	0.3	0.3	0.3	0.4	-0.4	-0.4	-0.3
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	0.1	0.3	0.2	-0.1	-0.1	-0.0	0.0	-0.0	0.2
Patch foraging time to switch 0 sec	0.2	0.5	1.1	-1.0	-0.8	-1.0	-1.0	-0.5	0.2	-0.3	-0.5	-0.3
Patch foraging water rate 0 sec	0.4	0.9	2.7	1.7	1.4	1.2	1.1	0.9	0.4	-0.3	-0.2	0.2
Patch foraging water rate 12 sec	0.2	0.4	0.9	0.8	0.8	0.5	0.7	0.1	-0.3	0.4	0.4	1.0
Patch foraging water rate 18 sec	1.1	1.6	2.4	-1.0	-1.2	-1.4	-1.3	-1.5	-1.2	1.1	1.2	1.5
Patch foraging water rate 24 sec	0.5	0.7	1.9	0.5	0.4	0.5	0.6	-0.2	-1.0	1.2	1.4	1.1
Patch foraging water rate 6 sec	0.4	0.5	0.9	1.0	0.8	0.3	0.7	0.5	0.9	-0.9	-0.8	0.4
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.7	-1.3	-0.4	-0.4	-0.2	-0.7	-0.8	0.9	0.9	-0.3
Distance traveled before self-admin	0.8	1.0	2.3	0.4	-0.0	0.4	0.6	1.0	1.5	-1.5	-1.3	-1.2
Distance traveled after self-admin	0.4	0.5	1.5	-0.8	-1.2	-0.8	-0.8	-0.7	-0.0	-0.0	0.1	0.4
Extensor digitorum longus weight	0.5	2.0	5.2	2.3	2.2	1.0	0.8	1.3	1.2	-1.2	-1.3	0.2
Bone: elastic displacement	0.2	0.2	0.6	0.1	-0.4	0.6	0.6	0.2	-0.3	0.5	0.8	-0.0
Bone: elastic work	0.8	1.1	2.4	1.3	1.3	1.6	1.4	0.7	-0.4	0.7	0.8	-0.2
Bone: endosteal estimation	0.3	0.6	1.2	0.8	1.0	0.4	0.3	-0.1	-1.0	1.1	1.0	0.8
Bone: endosteal perimeter	0.3	0.6	2.4	1.4	1.5	0.4	0.3	0.4	-0.1	0.1	-0.1	0.4
Epididymis fat weight	1.8	6.2	10.3	2.6	2.5	1.9	1.7	2.4	3.0	-3.1	-3.2	-1.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.6	0.8	0.4	0.1	-0.1	0.2	-0.0	-0.0	-0.0	0.2
Delta time in open arm before/after self-admin	1.8	1.8	3.7	-1.9	-1.8	-1.6	-1.4	-1.5	-1.0	0.9	0.8	0.2
Diff in mean of infusions in LGA sessions	0.5	0.6	1.6	-0.8	-0.7	-1.3	-1.2	-0.8	-0.2	-0.0	-0.2	0.5
Delay discount exponential model param	1.3	1.5	2.7	1.3	1.3	1.6	1.6	1.3	0.9	-0.8	-0.6	-0.9
Extinction: sum of active levers before priming	1.4	1.5	2.2	1.4	1.1	1.0	1.1	1.5	1.2	-1.1	-1.3	-1.2
Active lever presses in extinction session 6	0.8	0.8	1.3	1.2	1.1	0.7	1.0	0.8	0.8	-0.9	-1.0	-0.3
Bone: final force	0.1	0.1	0.3	0.5	0.5	0.4	0.1	0.1	-0.4	0.5	0.5	0.1
Bone: final moment	0.1	0.1	0.3	0.6	0.5	0.5	0.2	0.3	-0.2	0.3	0.3	-0.2
Food consumed during 24 hour testing period	0.8	1.1	1.5	-1.1	-1.2	-1.0	-1.0	-1.0	-1.2	1.2	1.2	-0.1
Glucose	0.9	1.4	2.1	0.7	1.0	1.3	1.4	1.4	1.2	-1.1	-1.0	-1.4
Heart weight	0.8	1.2	3.2	1.4	1.8	1.6	1.4	0.9	-0.1	0.3	0.2	-0.6
Delay discount hyperbolic model param	1.5	1.6	3.1	1.4	1.3	1.7	1.8	1.4	1.0	-0.8	-0.7	-1.0
Intermittent access intake day 1-15 change	0.1	0.2	0.9	1.0	0.3	0.4	-0.3	0.1	0.1	-0.1	0.0	0.7
Intermittent access intake escalation	0.1	0.3	1.1	1.1	0.4	0.7	0.1	0.5	0.4	-0.4	-0.2	0.3
Intermittent access intake escalation 2	0.2	0.2	0.5	0.7	-0.1	0.4	-0.1	0.4	0.7	-0.7	-0.5	0.0
Intermitt. access day 1 inactive lever presses	0.4	1.5	3.4	1.8	1.5	1.4	1.3	1.4	0.8	-0.7	-0.7	-0.8
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.4	-0.6	-0.3	-0.4	-0.6	-0.2	0.3	-0.4	-0.6	-0.6
Intermitt. access escalation Index	0.0	0.0	0.1	-0.3	-0.3	-0.3	-0.1	-0.1	-0.0	-0.0	-0.0	-0.2
Intermittent access day 1 total infusions	0.9	1.5	3.2	-1.0	-0.7	-0.5	-0.3	-1.2	-1.7	1.8	1.7	1.1
Intermittent access day 15 total infusions	0.4	0.6	1.3	0.1	0.1	0.3	-0.1	-0.5	-1.0	1.1	1.1	1.0
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.6	-0.1	-0.3	0.2	-0.2	-0.3	-0.7	0.8	0.8	0.6
Intermittent access total infusions	0.4	0.4	1.2	-0.2	-0.1	0.1	-0.1	-0.4	-1.1	1.1	1.0	0.4
Intermittent access day 1 locomotion	0.3	0.4	0.9	-0.6	-0.3	-0.1	0.1	-0.5	-0.9	0.9	0.9	-0.0
Intermittent access day 15 total locomotion	1.4	2.5	4.2	-1.3	-1.2	-1.2	-1.3	-1.7	-2.1	2.1	2.0	1.2
Intermittent access total locomotion	0.8	1.0	2.5	-0.8	-0.7	-0.4	-0.4	-0.8	-1.5	1.6	1.5	-0.0
Intermittent access standard deviation	0.4	0.9	2.1	1.4	1.0	1.0	0.4	1.0	0.9	-0.9	-0.9	-0.3
Left kidney weight	2.7	12.6	35.6	5.3	6.0	4.0	3.7	3.3	1.7	-1.5	-1.8	-0.7
Right kidney weight	3.8	17.1	42.7	6.0	6.5	4.7	4.4	4.2	2.3	-2.0	-2.4	-1.2
Cocaine induced anxiety	0.5	0.7	1.4	-1.1	-1.0	-1.2	-1.0	-0.9	-0.6	0.5	0.4	0.6
Post-drug Anxiety	1.0	1.0	2.5	-1.5	-1.1	-1.6	-1.4	-1.0	-0.6	0.3	0.1	0.1
Baseline Anxiety	0.2	0.3	1.0	0.1	0.6	0.1	0.2	0.4	0.3	-0.4	-0.8	-1.0
Tail length	1.4	5.5	11.9	1.5	2.3	0.6	0.5	-1.1	-3.1	3.2	2.9	3.4
Length with tail	1.9	8.3	27.7	4.6	5.3	2.9	2.6	1.3	-0.9	1.2	0.8	2.5
Length without tail	5.0	16.0	35.4	5.9	6.0	4.4	4.1	4.1	2.7	-2.4	-2.5	-1.1
Times rat made contact with spout	0.4	0.5	1.4	-0.2	-0.5	-0.2	-0.3	-0.5	-0.9	1.0	1.2	0.4
Lifetime Intake	0.2	0.3	0.9	-0.2	-0.0	0.3	0.1	-0.2	-0.9	1.0	0.8	0.1
Liver weight, left	0.9	1.4	5.1	2.0	2.3	1.1	1.1	0.8	0.3	-0.3	-0.4	0.8
Liver weight, right	1.0	1.7	5.6	2.3	2.4	1.2	1.2	1.1	-0.1	0.2	-0.1	0.1
Locomotor activity	0.2	0.4	1.5	1.2	0.9	0.3	0.0	0.3	0.0	-0.0	-0.1	0.9
Locomotor testing distance	0.6	1.0	2.1	1.4	1.0	1.0	0.8	1.2	1.1	-1.0	-0.9	-0.3
Locomotor testing rearing	0.1	0.1	0.4	0.0	-0.5	-0.5	-0.6	-0.2	0.2	-0.4	-0.3	0.4
Locomotion in novel chamber	3.2	4.2	10.2	-1.1	-1.1	-0.6	-0.8	-1.7	-2.9	3.1	3.2	1.6
Locomotion in novel chamber post-restriction	0.8	1.4	4.0	0.6	0.3	0.3	0.3	-0.3	-1.8	2.0	1.8	0.8
Fecal boli incidents, locomotor time 1	0.6	0.9	2.1	1.1	1.4	1.1	1.1	0.9	0.7	-0.6	-0.5	0.4
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	-0.3	-0.4	-0.2	-0.7	-0.1	-0.4	0.4	0.3	-0.5
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.7	0.2	0.7	0.7	0.8	0.4	-0.4	0.5	0.4	-0.8
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.2	-0.1	0.0	0.1	-0.0	0.3	-0.3	-0.2	0.3
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.2	-0.0	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.0
Rest time, locomotor task time 1	0.2	0.2	0.5	-0.2	-0.6	-0.1	-0.3	-0.3	-0.5	0.6	0.7	-0.1
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.1	0.1	0.0	0.4	0.1	0.4	-0.5	-0.5	-0.1
Vertical activity count, locomotor time 1	0.5	1.1	1.3	1.1	1.1	0.8	1.1	1.1	1.1	-1.1	-1.1	-0.6
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	0.2	0.5	0.1	0.2	-0.0	-0.3	0.3	0.2	0.4
Bouts of movement, locomotor time 2	0.7	1.2	2.8	1.5	1.7	1.3	1.3	1.1	0.5	-0.5	-0.6	0.2
Total resting periods, locomotor time 2	1.1	1.9	3.7	1.8	1.9	1.6	1.6	1.5	0.9	-0.8	-0.9	-0.4
Rest time, locomotor task time 2	0.1	0.2	0.3	-0.4	-0.3	-0.2	-0.4	-0.4	-0.5	0.5	0.5	-0.5
Distance moved, locomotor task time 2	0.1	0.2	0.2	0.5	0.1	0.3	0.5	0.3	0.5	-0.4	-0.4	0.4
Vertical activity count, locomotor time 2	1.7	2.3	3.7	1.9	1.5	1.6	1.9	1.6	1.5	-1.4	-1.3	-0.6
Light reinforcement 1	0.1	0.3	1.3	-0.6	-1.1	-0.5	-0.3	0.0	0.2	-0.3	-0.2	-0.8
Light reinforcement 2	1.2	1.8	3.2	1.0	0.1	0.9	1.1	1.5	1.8	-1.7	-1.4	-1.7
Bone: marrow area	0.3	0.6	1.3	0.7	0.9	0.4	0.3	-0.1	-1.0	1.1	1.0	0.8
Bone: maximum diameter	0.8	1.4	4.4	2.1	2.0	0.9	0.9	1.1	0.6	-0.6	-0.8	0.1
Bone: maximum force	0.1	0.2	0.5	0.6	0.7	0.3	0.0	0.0	-0.4	0.5	0.3	0.2
Bone: maximum moment	0.1	0.2	0.5	0.7	0.7	0.4	0.2	0.2	-0.3	0.3	0.2	-0.1
Mean time between licks in bursts	0.1	0.2	0.5	-0.5	-0.6	-0.4	-0.5	-0.6	-0.3	0.3	0.4	0.7
Mean num. licks in bursts	0.6	1.0	2.2	-1.3	-1.5	-1.1	-1.2	-1.1	-0.5	0.4	0.6	0.6
Cd content in liver	0.1	0.2	0.6	0.1	-0.2	0.1	0.0	-0.1	-0.5	0.6	0.8	0.2
Co content in liver	0.5	0.6	2.1	-0.9	-1.5	-0.5	-0.5	-0.6	-0.6	0.7	0.8	0.3
Cu content in liver	1.3	1.5	3.1	1.3	0.8	0.4	0.6	1.1	1.7	-1.8	-1.7	-0.5
Fe content in liver	5.0	6.1	9.7	2.9	2.4	1.6	1.6	2.4	3.1	-3.1	-3.1	-1.1
K content in liver	0.1	0.0	0.1	-0.0	-0.2	-0.4	-0.1	-0.1	-0.3	0.3	0.1	0.2
Mg content in liver	1.1	1.1	2.1	-1.1	-1.2	-1.4	-1.2	-1.3	-0.7	0.6	0.6	1.1
Mn content in liver	0.1	0.1	0.4	-0.0	-0.3	-0.2	0.1	-0.3	-0.4	0.5	0.6	0.5
Na content in liver	0.3	0.3	0.8	0.3	0.8	0.7	0.9	0.5	-0.5	0.5	0.3	-0.3
Rb content in liver	2.4	2.8	5.9	-2.1	-2.2	-2.4	-2.4	-1.7	0.1	-0.5	-0.5	0.8
Se content in liver	3.0	3.5	6.3	1.7	1.3	1.0	1.1	2.1	2.2	-2.3	-2.5	-1.9
Sr content in liver	0.6	0.5	1.8	1.3	1.0	0.7	0.7	0.6	-0.1	0.2	0.1	0.5
Zn content in liver	2.0	2.2	5.1	2.3	2.0	1.7	1.7	1.7	1.0	-0.8	-0.8	-0.5
Bone: minimum diameter	0.1	0.3	0.9	0.0	-0.1	-0.8	-1.0	-0.5	-0.3	0.2	-0.0	0.6
Time in familiar zone, hab. session 1	0.9	0.9	1.4	1.1	0.7	0.9	0.9	1.2	0.8	-0.7	-0.6	-1.1
Time in novel zone, hab. session 1	0.2	0.2	1.0	-0.1	0.2	-0.3	-0.4	-0.5	-0.2	0.1	-0.0	1.0
Total zone transitions, hab. session 1	4.4	6.2	11.7	-1.5	-1.1	-1.7	-1.7	-2.5	-3.4	3.4	3.2	2.5
Total locomotion distance, hab. session 1	2.6	3.7	5.3	-1.7	-1.4	-2.0	-2.1	-2.3	-2.1	2.0	1.8	1.8
Locomotion velocity, hab. session 1	3.1	4.4	6.1	-2.2	-1.9	-2.2	-2.3	-2.5	-2.2	2.0	1.8	1.6
Time in familiar zone, hab. session 2	0.7	0.7	2.0	0.3	0.1	-0.6	-0.7	0.1	1.2	-1.4	-1.4	0.2
Time in novel zone, hab. session 2	0.3	0.3	0.7	-0.4	-0.2	0.5	0.5	-0.0	-0.7	0.8	0.8	-0.2
Total zone transitions, hab. session 2	1.0	1.3	4.0	-0.1	-0.4	0.3	0.3	-0.4	-1.7	2.0	2.0	0.7
Total locomotion distance, hab. session 2	1.0	1.3	3.1	-0.9	-1.0	-0.4	-0.4	-0.8	-1.6	1.7	1.8	0.5
Locomotion velocity, hab. session 2	1.0	1.3	3.4	-0.8	-0.9	-0.2	-0.2	-0.7	-1.6	1.8	1.9	0.4
Novel to familiar place preference ratio	0.2	0.2	0.7	0.1	0.3	0.6	0.8	0.5	0.0	0.1	0.1	-0.3
Novelty place preference	0.2	0.2	0.8	0.2	0.4	0.8	0.9	0.6	0.2	-0.1	-0.0	-0.5
Time in novel zone, NPP test	0.3	0.3	1.1	0.4	0.5	0.9	1.0	0.7	0.3	-0.1	-0.0	-0.5
Total zone transitions, NPP test	0.7	1.0	2.6	0.1	-0.0	0.1	0.0	-0.5	-1.4	1.6	1.6	1.2
Total locomotion distance, NPP test	1.4	1.9	3.0	-1.1	-1.0	-1.3	-1.4	-1.4	-1.7	1.7	1.5	1.0
Locomotion velocity, NPP test	2.1	3.0	4.6	-1.4	-1.3	-1.5	-1.6	-1.8	-2.1	2.1	2.0	1.5
Intraocular pressure	0.1	0.2	0.4	0.3	0.6	-0.0	-0.3	-0.0	0.4	-0.5	-0.5	0.4
Delta distance traveled before/after self-admin	2.7	2.9	3.7	-1.5	-1.5	-1.4	-1.8	-1.8	-1.7	1.7	1.7	1.9
Delta ambulatory time before/after self-admin	1.6	2.0	2.9	-1.5	-1.6	-1.4	-1.7	-1.6	-1.2	1.1	1.1	1.4
Parametrial fat weight	0.8	2.0	4.6	1.6	2.2	1.5	1.8	1.5	0.9	-0.9	-1.0	-0.8
Pavlov. Cond. lever latency	4.0	5.0	7.7	2.6	2.6	2.7	2.8	2.5	1.8	-1.6	-1.4	-1.5
Pavlov. Cond. magazine entry latency	3.6	4.7	6.9	-1.7	-1.3	-2.0	-2.0	-2.3	-2.6	2.5	2.3	2.3
Pavlov. Cond. change in total contacts	1.9	2.0	4.0	-1.4	-1.3	-2.0	-2.0	-1.6	-1.0	0.8	0.6	1.2
Pavlov. Cond. index score	3.8	4.8	6.1	-2.1	-1.9	-2.4	-2.4	-2.5	-2.3	2.1	1.8	2.1
Pavlov. Cond. latency score	4.0	5.0	6.2	-2.3	-2.1	-2.4	-2.4	-2.5	-2.4	2.2	2.0	2.0
Pavlov. Cond. lever contacts	5.4	6.4	10.1	-2.9	-2.8	-3.1	-3.2	-2.9	-2.1	1.8	1.6	1.8
Pavlov. Cond. magazine entry number	4.5	5.7	7.5	2.0	1.5	2.5	2.4	2.7	2.7	-2.5	-2.2	-2.7
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.4	0.7	0.4	1.2	1.1	1.1	1.0	-0.9	-0.7	-1.2
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.0	5.5	-2.0	-1.7	-2.3	-2.3	-2.3	-2.0	1.8	1.5	1.8
Pavlov. Cond. response bias	4.4	5.5	7.2	-2.2	-1.8	-2.7	-2.6	-2.7	-2.4	2.2	1.9	2.5
Pavlov. Cond. lever latency	0.5	0.7	1.4	0.9	0.8	1.0	1.2	1.0	0.6	-0.5	-0.4	-0.7
Pavlov. Cond. magazine entry latency	0.0	0.0	0.2	0.1	0.2	-0.3	-0.4	-0.1	-0.1	0.0	-0.0	0.4
Pavlov. Cond. change in total contacts	0.2	0.3	0.9	-0.2	0.0	-0.4	-0.7	-0.7	-0.6	0.5	0.4	0.9
Pavlov. Cond. index score	0.4	0.5	0.7	-0.5	-0.3	-0.6	-0.8	-0.8	-0.8	0.7	0.6	0.8
Pavlov. Cond. latency score	0.3	0.4	0.6	-0.5	-0.3	-0.6	-0.8	-0.7	-0.7	0.7	0.6	0.8
Pavlov. Cond. lever contacts	0.4	0.6	1.6	-0.9	-0.8	-1.1	-1.3	-0.9	-0.5	0.3	0.2	0.5
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.0	-0.1	0.2	0.3	0.2	0.2	-0.2	-0.1	-0.3
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.3	-0.7	-0.5	-0.3	-0.2	-0.7	-1.1	1.2	1.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	-0.4	-0.2	-0.6	-0.8	-0.7	-0.8	0.7	0.6	0.9
Pavlov. Cond. response bias	0.7	0.9	2.1	-1.1	-0.8	-1.3	-1.5	-1.1	-0.7	0.5	0.3	0.7
Time in closed arm before self-admin	0.8	1.0	3.2	0.9	1.1	1.6	1.8	0.9	0.5	-0.3	-0.0	0.1
Time in closed arm after self-admin	0.8	0.8	1.9	1.1	1.2	1.4	1.1	0.7	-0.1	0.3	0.5	0.8
Time in open arm before self-admin	0.1	0.1	0.1	0.1	0.3	-0.1	-0.2	-0.2	-0.3	0.3	0.3	0.3
Time in open arm after self-admin	1.3	1.4	2.7	-1.6	-1.6	-1.6	-1.5	-1.3	-0.8	0.6	0.4	0.2
Bone: periosteal estimation	0.3	0.5	2.1	1.4	1.5	0.5	0.4	0.4	-0.2	0.2	0.0	0.4
Bone: periosteal perimeter	0.4	0.8	2.6	1.5	1.6	0.4	0.2	0.6	0.5	-0.6	-0.8	0.0
Bone: post-yield work	0.3	0.4	0.9	0.6	0.2	0.3	0.0	0.7	0.9	-0.9	-0.9	-0.7
Progressive ratio test 1 active lever presses	0.4	0.5	1.2	0.0	0.4	0.3	0.3	-0.4	-1.0	1.1	1.0	0.8
Progressive ratio test 1 breakpoint	0.4	0.5	1.2	0.0	0.4	0.3	0.3	-0.4	-1.1	1.1	1.0	0.8
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.6	0.6	0.8	0.7	0.6	0.2	-0.3	0.4	0.3	0.1
Progressive ratio test 2 active lever presses	1.3	1.5	2.4	1.2	1.5	1.5	1.4	0.5	-1.1	1.4	1.3	0.0
Progressive ratio test 2 breakpoint	1.3	1.4	2.3	1.2	1.5	1.5	1.4	0.6	-1.1	1.4	1.2	0.0
Progressive ratio test 2 inactive lever presses	0.6	0.9	2.3	0.9	1.5	1.0	0.5	0.2	-1.1	1.2	0.9	0.5
Incentive Sensitization - Responses	1.2	1.7	3.4	1.5	1.9	1.7	1.6	1.1	-0.6	0.9	0.7	-0.7
Incentive Sensitization - Breakpoint	1.2	1.6	3.1	1.5	1.8	1.7	1.6	1.1	-0.7	0.9	0.8	-0.8
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.3	0.9	1.2	0.7	0.7	0.5	-0.1	0.1	0.0	0.1
Progressive ratio	0.4	0.6	1.5	-0.6	-0.0	-0.3	-0.2	-0.6	-1.2	1.2	1.1	0.1
Food seeking constrained by brief footshock	1.4	1.7	2.7	1.2	0.6	1.5	1.5	1.6	1.5	-1.3	-0.9	-1.1
Seeking ratio, punishment vs. effort	0.8	1.1	1.8	1.2	0.5	1.2	1.1	1.2	1.3	-1.1	-0.8	-0.4
Retroperitoneal fat weight	1.5	6.4	10.8	2.9	3.3	1.9	2.1	2.6	2.6	-2.6	-3.0	-1.1
Reaction time number correct	0.5	0.9	2.0	1.4	1.3	1.2	1.3	0.9	-0.1	0.3	0.4	-0.3
Reaction time mean minus median	4.6	11.4	16.2	-3.4	-2.7	-3.9	-3.8	-4.0	-3.3	2.9	2.6	3.5
Reaction time mean minus median AUC	4.6	11.6	16.5	-3.6	-2.7	-3.8	-3.6	-4.1	-3.4	3.0	2.8	3.3
Reaction time num false alarms	0.1	0.1	0.3	0.2	0.1	0.5	0.3	0.3	-0.2	0.3	0.4	-0.6
Reaction time num false alarms AUC	0.1	0.1	0.4	0.4	0.3	0.4	0.2	0.4	0.2	-0.1	-0.1	-0.7
Reaction time trials correct on left	0.5	0.9	2.0	1.4	1.3	1.2	1.3	0.9	-0.1	0.3	0.4	-0.3
Reaction time trials on left	0.4	0.8	1.8	1.3	1.2	1.1	1.2	0.8	-0.2	0.4	0.4	-0.2
Reaction time mean	3.1	4.9	9.1	-3.0	-2.9	-3.0	-3.0	-2.4	-1.1	0.8	0.7	1.0
Reaction time mean AUC	3.1	4.9	9.2	-2.9	-2.8	-3.0	-3.0	-2.4	-1.0	0.7	0.7	1.2
Median of all reaction times	1.7	2.4	5.7	-2.3	-2.4	-2.1	-2.1	-1.3	0.0	-0.3	-0.3	-0.1
Reaction time omissions	1.7	2.5	4.2	-1.8	-1.8	-2.0	-1.9	-1.9	-1.2	1.0	1.0	1.2
Reaction time false alarm rate	0.1	0.1	0.2	-0.1	-0.1	0.0	-0.2	0.1	0.4	-0.4	-0.4	-0.5
Reaction time premature initiation rate	7.0	9.7	13.1	-3.6	-3.2	-2.9	-2.9	-3.3	-3.4	3.3	3.3	1.9
Reaction time premature initiations	4.0	7.2	10.8	-2.7	-2.4	-2.1	-2.1	-2.7	-3.3	3.3	3.3	1.8
Std. dev. reaction times	5.1	9.4	14.2	-3.4	-2.7	-3.8	-3.8	-3.6	-2.7	2.3	2.0	2.7
Reaction time trials completed	0.4	0.8	1.8	1.3	1.2	1.1	1.2	0.8	-0.2	0.4	0.4	-0.2
Reaction time trials AUC	0.5	0.9	2.0	1.4	1.3	1.2	1.3	1.0	0.0	0.2	0.2	-0.4
Run reversals in cocaine runway, females	0.2	0.2	0.9	-0.7	-0.9	-0.5	-0.2	-0.2	0.0	-0.1	0.0	-0.0
Run reversals in cocaine runway, males	0.9	0.9	1.5	1.2	0.7	1.0	0.9	1.0	1.1	-1.0	-0.8	-0.3
Latency to leave start box in cocaine runway	0.4	0.4	1.4	0.0	0.2	-0.4	-0.2	0.1	0.9	-1.1	-1.2	-0.1
Latency to leave start box in cocaine runway, F	1.0	1.2	3.0	0.8	1.0	0.3	0.4	0.7	1.5	-1.6	-1.7	-0.2
Latency to leave start box in cocaine runway, M	0.4	0.4	0.6	-0.7	-0.7	-0.6	-0.4	-0.7	-0.6	0.6	0.7	0.5
Std. dev. time between licks in bursts	0.1	0.1	0.3	-0.0	0.3	0.3	0.2	0.0	-0.5	0.5	0.5	-0.1
Total sessions with >9 infusions	1.0	1.2	2.9	1.2	1.1	1.7	1.6	1.3	0.7	-0.6	-0.4	-0.6
Short access day 1 total inactive lever presses	0.6	0.8	2.9	1.3	1.7	1.1	1.0	0.5	-0.3	0.4	0.2	0.4
Short access day 10 total inactive lever presses	0.1	0.2	0.6	0.7	0.8	0.1	-0.1	0.4	0.3	-0.4	-0.6	-0.4
Short access day 1 total infusions	0.6	0.8	2.0	0.8	0.9	1.4	1.4	1.0	0.5	-0.4	-0.3	-0.5
Short access day 10 total infusions	0.1	0.2	0.4	0.0	0.1	0.5	0.3	0.0	-0.6	0.6	0.6	0.1
Short access total infusions	0.2	0.2	0.7	0.1	0.4	0.8	0.8	0.4	-0.2	0.3	0.3	-0.5
Short access day 1 locomotion	0.5	0.6	1.5	0.8	0.6	1.2	1.1	0.9	0.5	-0.3	-0.2	-0.4
Short access day 10 total locomotion	0.4	0.8	1.3	1.1	1.2	1.1	1.1	1.0	0.6	-0.5	-0.5	-0.4
Short access total locomotion	0.1	0.1	0.3	0.2	0.2	0.5	0.5	0.3	-0.1	0.1	0.2	-0.2
One hour access (0.3 mA shock)	1.0	1.1	2.8	-0.4	-0.3	-0.1	-0.3	-0.9	-1.5	1.7	1.6	1.0
Compulsive drug intake	1.3	1.6	4.2	-1.7	-2.0	-1.6	-1.4	-1.4	-0.5	0.5	0.6	0.4
One hour access (shock baseline)	0.3	0.4	1.1	0.4	0.7	0.5	0.0	-0.1	-1.0	1.0	0.8	0.5
Social response proportion	1.3	1.4	4.6	-0.4	-0.3	-0.8	-1.0	-1.3	-1.3	1.2	1.2	2.1
Social responses	4.9	6.3	10.9	-2.1	-1.6	-2.4	-2.4	-2.9	-2.7	2.5	2.3	3.3
Social time	0.9	1.3	2.9	-1.4	-1.2	-1.6	-1.7	-1.3	-0.3	-0.0	-0.2	0.8
Soleus weight	0.2	0.7	2.0	1.4	1.4	0.2	0.3	0.5	0.7	-0.8	-0.9	0.5
Bone: stiffness	0.2	0.4	0.9	-0.3	0.2	-0.3	-0.6	-0.6	-1.0	0.9	0.7	0.3
Tibialis anterior weight	0.5	1.6	4.8	2.2	2.2	1.3	1.2	1.0	0.3	-0.2	-0.2	0.8
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.5	0.1	-0.2	-0.4	-0.1	-0.0	0.6	-0.6	-0.7	0.0
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.7	0.2	0.9	0.5	0.3	0.3	0.2	-0.2	-0.3	-0.2
Time to tail flick, test, before self-admin	1.0	1.1	2.9	1.5	1.7	1.4	1.3	0.9	-0.1	0.2	0.1	-0.0
Time to tail flick, test, after self-admin	0.3	0.3	0.5	-0.6	-0.5	-0.5	-0.6	-0.1	0.4	-0.4	-0.5	-0.7
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.6	0.4	0.9	0.9	0.4	1.0	0.8	-0.8	-0.8	-1.3
Delta time to tail flick, test, before/after SA	0.9	1.0	2.6	-1.3	-1.6	-1.3	-1.3	-0.8	-0.1	-0.0	0.1	-0.4
Tibia length	0.7	1.9	7.2	2.1	2.7	1.7	1.3	0.9	-0.2	0.3	0.0	0.4
Ambulatory time before self-admin	0.4	0.7	1.5	0.3	-0.1	0.4	0.5	0.7	1.2	-1.2	-1.0	-1.0
Ambulatory time after self-admin	0.4	0.5	1.6	-0.9	-1.3	-0.8	-0.8	-0.6	0.2	-0.2	-0.1	0.5
Bone: tissue strength	2.5	2.5	3.8	1.9	1.5	1.7	1.9	1.9	1.2	-1.0	-0.8	-1.8
Total heroin consumption	0.6	0.7	1.9	-0.9	-1.0	-1.4	-1.1	-0.9	-0.6	0.4	0.2	0.4
Bone: trabecular number	2.2	3.6	8.0	2.8	2.6	1.9	1.8	2.0	1.5	-1.4	-1.5	-0.5
Bone: trabecular spacing	0.2	0.3	1.0	-1.0	-0.6	-0.6	-0.7	-0.4	-0.1	-0.0	-0.1	-0.5
Bone: trabecular thickness	4.9	6.2	9.6	3.1	2.9	2.6	2.6	2.8	2.0	-1.9	-2.0	-2.1
Bone: trabecular tissue density	0.1	0.1	0.7	0.1	0.9	0.2	0.0	0.1	-0.0	-0.1	-0.3	-0.5
Water consumed over 24 hours	0.4	0.6	1.8	0.4	0.2	0.2	0.2	-0.1	-1.2	1.3	1.3	0.3
Number of responses in last shaping day	0.6	0.6	1.0	0.9	0.4	0.7	0.6	0.9	1.0	-1.0	-0.9	-0.4