Hub : Genes

LOC134481143

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression LOC134481143 0.75 0.12 1.3e-08 0.29 0.23 0.32 0.31 1.6e-07 3.2e-06 2.7e-08 3.7e-08
2 Eye gene expression LOC134481143 0.54 0.2 4.0e-03 0.26 0.19 0.2 0.2 7.2e-05 6.6e-04 6.1e-04 5.7e-04
3 Adipose gene expression LOC134481143 0.64 0.12 0.0e+00 0.25 0.26 0.3 0.28 3.7e-27 1.9e-28 1.6e-33 2.3e-31
4 Liver gene expression LOC134481143 0.67 0.12 0.0e+00 0.22 0.22 0.22 0.24 1.1e-23 2.6e-24 2.9e-24 3.7e-26
5 IL gene expression LOC134481143 0.72 0.13 9.7e-10 0.39 0.4 0.41 0.42 1.9e-10 1.2e-10 5.2e-11 3.1e-11
6 LHb gene expression LOC134481143 0.7 0.13 3.5e-08 0.32 0.29 0.31 0.32 2.9e-08 1.6e-07 4.9e-08 2.0e-08
7 PL gene expression LOC134481143 0.8 0.09 0.0e+00 0.43 0.52 0.54 0.54 1.8e-50 6.7e-67 2.2e-70 3.0e-70
8 BLA gene expression LOC134481143 0.58 0.14 3.6e-12 0.13 0.23 0.23 0.23 3.3e-07 1.5e-12 1.9e-12 2.8e-12
9 Brain gene expression LOC134481143 0.66 0.11 0.0e+00 0.36 0.42 0.42 0.43 7.8e-35 1.3e-41 1.3e-42 4.8e-43
10 pVTA gene expression LOC134481143 0.82 0.07 0.0e+00 0.44 0.59 0.62 0.61 2.0e-38 8.9e-59 8.2e-63 3.8e-61
11 IC gene expression LOC134481143 0.84 0.07 0.0e+00 0.39 0.5 0.5 0.53 2.1e-17 1.0e-23 9.0e-24 9.8e-26
12 NAcc gene expression LOC134481143 0.89 0.06 0.0e+00 0.49 0.53 0.55 0.54 4.0e-86 6.2e-95 1.3e-99 4.7e-99
13 RMTg gene expression LOC134481143 0.63 0.14 1.5e-05 0.23 0.23 0.2 0.2 7.2e-07 1.0e-06 6.5e-06 4.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density2.64.47.2-2.7-2.7-2.5-2.3-2.5-2.2-2.2-2.3-1.7-1.7-1.4-1.4-0.9
Area under the delay curve0.40.51.41.21.00.90.71.00.60.70.80.20.40.10.2-0.1
BMI with tail3.110.514.1-3.8-3.0-3.4-3.4-3.3-3.3-3.3-3.4-3.3-3.2-3.0-3.0-2.7
BMI without tail4.213.018.5-4.3-4.3-4.2-4.0-3.5-4.0-3.6-3.3-3.5-3.4-2.9-2.9-2.1
Body weight14.462.897.9-9.9-9.2-8.9-8.7-8.1-8.6-8.1-7.5-7.4-7.4-6.5-6.5-4.6
Weight adjusted by age0.71.11.9-1.1-1.1-1.2-1.1-1.2-0.8-1.3-1.4-0.6-1.1-1.0-1.1-0.6
Bone surface4.48.011.7-3.4-3.3-3.2-3.1-3.1-3.0-2.9-2.9-2.5-2.5-2.3-2.3-1.5
Bone volume2.74.86.6-2.6-2.4-2.4-2.4-2.5-2.3-2.3-2.4-2.0-2.0-1.8-1.8-1.3
Breakpoint value in progressive ratio session0.00.00.20.50.2-0.0-0.10.10.20.10.2-0.1-0.00.0-0.00.0
Number of licking bursts0.20.41.2-1.1-1.0-0.8-0.6-0.8-0.6-0.6-0.5-0.2-0.3-0.1-0.10.3
Context. condit. distance diff. score1.31.53.6-1.4-1.9-1.7-1.5-1.3-1.4-1.2-0.9-1.0-1.1-0.8-0.8-0.1
Locomotion velocity, session 10.60.60.90.90.90.60.90.80.90.80.90.80.60.70.60.5
Locomotion distance, session 12.02.63.61.91.81.61.71.71.71.61.61.51.51.51.41.1
Locomotion velocity, session 20.50.50.80.70.60.70.80.80.70.80.90.70.70.70.70.6
Locomotion distance, session 24.15.86.62.31.92.52.42.42.32.52.62.52.52.52.42.3
Locomotion velocity, session 30.00.00.1-0.4-0.3-0.2-0.2-0.2-0.2-0.2-0.1-0.2-0.2-0.1-0.2-0.0
Locomotion distance, session 30.40.40.60.70.40.50.60.40.60.60.50.70.70.80.70.8
Stereotopy head waving bouts, day 32.32.76.2-2.5-2.2-1.8-1.8-1.7-1.8-1.7-1.4-1.3-1.3-1.1-1.1-0.6
Stereotopy head waving duration, day 30.20.20.8-0.9-0.3-0.4-0.4-0.4-0.5-0.5-0.4-0.4-0.5-0.5-0.4-0.5
Locomotion velocity, session 70.20.20.70.80.80.30.40.60.50.40.50.10.0-0.0-0.0-0.2
Locomotion distance, session 70.91.11.80.90.81.01.01.21.01.11.41.01.01.01.01.0
Stereotopy head waving bouts, day 70.50.60.70.60.70.80.80.80.80.80.90.80.80.80.80.7
Stereotopy head waving duration, day 70.50.61.10.81.00.90.90.80.90.80.80.70.70.60.60.4
Locomotion velocity, session 80.10.10.3-0.2-0.3-0.5-0.4-0.2-0.4-0.4-0.2-0.4-0.5-0.4-0.4-0.4
Locomotion distance, session 80.30.41.0-0.8-1.0-0.8-0.8-0.6-0.7-0.6-0.4-0.5-0.5-0.4-0.4-0.0
Degree of sensitization distance1.01.01.70.91.11.21.11.31.01.11.20.90.90.80.80.6
Degree of sensitization stereotypy0.50.61.21.11.00.70.90.70.90.70.70.70.60.60.50.4
Conditioned locomotion0.10.10.1-0.2-0.1-0.4-0.2-0.3-0.2-0.3-0.3-0.1-0.3-0.2-0.2-0.2
Cocaine response after cond. corrected3.34.06.3-1.6-0.9-1.8-1.7-1.9-1.8-2.0-2.3-2.2-2.2-2.3-2.3-2.5
Cocaine response after cond. not corrected2.63.04.9-1.4-0.8-1.6-1.5-1.5-1.5-1.7-1.9-1.9-1.9-2.0-2.0-2.2
Cocaine response before conditioning0.70.81.50.70.40.70.71.20.80.91.21.00.91.00.91.2
Saline control response0.40.62.3-0.5-1.5-0.9-0.5-0.3-0.3-0.20.30.50.20.70.71.5
Bone: connectivity density3.96.111.4-3.1-3.4-3.1-2.8-2.8-2.7-2.6-2.4-2.0-2.0-1.6-1.6-0.9
Bone: cortical apparent density0.10.10.40.30.50.20.10.30.10.10.1-0.2-0.1-0.3-0.3-0.6
Bone: cortical area1.62.43.6-1.6-1.8-1.9-1.8-1.3-1.7-1.6-1.3-1.6-1.6-1.5-1.4-0.8
Bone: cortical porosity0.00.00.1-0.20.0-0.10.00.00.20.00.00.20.10.20.20.3
Bone: cortical porosity0.40.50.60.60.60.60.60.70.80.70.70.70.70.70.70.8
Bone: cortical thickness1.52.43.5-1.8-1.8-1.9-1.8-1.4-1.7-1.6-1.4-1.5-1.6-1.4-1.4-0.8
Bone: cortical thickness0.40.41.4-0.9-1.2-0.9-0.8-0.5-0.8-0.6-0.2-0.4-0.4-0.3-0.20.4
Bone: cortical tissue density0.10.10.30.40.60.30.20.30.20.20.1-0.1-0.0-0.2-0.2-0.6
Condit. Reinf. active minus inactive responses0.20.20.90.91.00.40.50.50.50.40.30.20.10.00.0-0.3
Condit. Reinf. active-inactive response ratio0.10.10.60.30.4-0.10.0-0.0-0.0-0.2-0.2-0.3-0.4-0.5-0.5-0.7
Condit. Reinf. active responses0.91.11.91.41.11.11.11.01.11.11.11.01.00.90.90.8
Condit. Reinf. inactive responses3.03.74.31.91.42.01.81.91.82.02.11.92.12.02.02.0
Incentive salience index mean0.80.91.91.41.21.01.01.01.11.01.00.80.80.70.80.6
Condit. Reinf. lever presses1.11.52.21.51.21.21.11.21.31.21.31.11.21.11.21.1
Condit. Reinf. active minus inactive responses0.10.20.7-0.2-0.8-0.7-0.5-0.2-0.4-0.30.2-0.1-0.3-0.1-0.00.3
Condit. Reinf. active-inactive response ratio0.10.10.30.1-0.2-0.10.00.30.10.20.50.20.10.30.30.5
Condit. Reinf. active responses0.10.20.8-0.1-0.9-0.9-0.5-0.1-0.4-0.30.2-0.1-0.30.00.00.4
Condit. Reinf. inactive responses0.10.10.4-0.1-0.5-0.6-0.3-0.2-0.2-0.20.0-0.0-0.20.00.00.3
Condit. Reinf. lever presses0.00.00.20.1-0.1-0.20.10.20.10.20.40.30.10.30.30.4
Condit. Reinf. lever reinforcers received0.10.10.50.3-0.5-0.4-0.10.30.00.10.60.30.10.40.40.7
Conditioned reinforcement - actives1.01.63.8-2.0-1.7-1.7-1.4-1.4-1.1-1.4-1.1-0.7-1.2-0.9-0.8-0.1
Conditioned reinforcement - inactives0.10.10.6-0.80.2-0.6-0.4-0.20.3-0.3-0.10.0-0.1-0.00.10.4
Conditioned locomotion0.81.14.5-2.1-1.8-1.4-1.1-0.8-1.2-0.7-0.2-0.5-0.4-0.10.00.6
Patch foraging indifference point 0 sec0.00.10.10.1-0.30.10.1-0.4-0.1-0.1-0.30.30.30.30.30.3
Patch foraging indifference point AUC0.40.51.5-0.4-0.8-1.2-1.0-0.8-0.4-0.9-0.9-0.4-0.8-0.5-0.6-0.2
Delay disc. indifference point, 0s delay4.14.57.8-1.6-1.3-2.1-2.0-1.6-2.3-2.0-1.7-2.8-2.4-2.4-2.4-2.4
Delay disc. indifference point, 16s delay0.30.30.80.40.50.70.70.90.60.70.70.70.50.20.30.3
Delay disc. indifference point, 2s delay0.50.61.81.31.30.80.71.00.40.60.8-0.30.1-0.2-0.1-0.6
Delay disc. indifference point, 24s delay0.70.81.31.21.00.91.01.00.90.90.90.70.80.70.70.4
Delay disc. indifference point, 4s delay0.20.20.90.70.90.40.20.50.20.30.5-0.5-0.0-0.1-0.1-0.4
Delay disc. indifference point, 8s delay1.11.32.21.51.21.41.01.21.21.21.20.91.10.80.90.9
Indifference point function ln k0.50.91.50.5-0.10.90.90.70.50.91.11.11.11.11.21.2
Indifference point function log k0.50.91.50.5-0.10.90.90.70.50.91.11.11.11.11.21.2
Patch foraging total patch changes 0 sec0.10.20.40.0-0.20.30.3-0.20.10.1-0.10.60.50.60.60.6
Patch foraging total patch changes 12 sec0.60.81.7-0.4-0.6-1.0-0.9-1.1-0.5-1.1-1.3-0.5-0.9-0.8-0.9-0.8
Patch foraging total patch changes 18 sec0.10.10.50.2-0.2-0.4-0.3-0.7-0.0-0.4-0.70.0-0.00.10.00.1
Patch foraging total patch changes 24 sec0.91.63.61.00.20.91.00.91.01.11.11.51.51.71.71.9
Patch foraging total patch changes 6 sec0.10.10.4-0.0-0.5-0.3-0.3-0.6-0.1-0.3-0.50.20.00.10.10.3
Patch foraging time to switch 0 sec1.63.29.1-1.40.2-0.6-1.1-1.1-1.5-1.3-1.8-2.5-1.9-2.4-2.4-3.0
Patch foraging water rate 0 sec0.71.46.00.1-1.2-0.10.2-0.10.20.50.81.31.21.81.82.4
Patch foraging water rate 12 sec1.02.25.80.8-0.11.01.01.10.81.41.61.51.71.92.12.4
Patch foraging water rate 18 sec2.43.87.31.20.61.61.61.91.32.12.41.82.22.32.42.7
Patch foraging water rate 24 sec0.50.83.9-0.6-1.2-0.3-0.2-0.1-0.30.20.60.40.71.11.22.0
Patch foraging water rate 6 sec0.91.34.4-0.3-0.50.50.60.50.21.01.21.01.41.71.72.1
Seeking ratio, delayed vs. immediate footshock0.40.51.50.40.51.21.00.60.30.90.60.61.00.70.70.2
Distance traveled before self-admin0.70.91.60.51.31.31.11.10.91.01.20.60.90.70.80.5
Distance traveled after self-admin1.51.84.62.11.61.01.11.21.81.11.31.31.01.11.11.2
Extensor digitorum longus weight3.212.524.0-4.5-4.9-4.5-4.1-3.6-3.9-3.6-3.0-3.0-3.1-2.6-2.4-0.9
Bone: elastic displacement0.10.10.3-0.4-0.5-0.5-0.4-0.5-0.3-0.3-0.3-0.2-0.2-0.1-0.10.2
Bone: elastic work2.02.65.1-2.0-2.3-2.1-1.9-1.8-1.7-1.7-1.5-1.2-1.3-1.0-1.0-0.1
Bone: endosteal estimation0.30.51.8-1.0-1.3-0.9-0.8-1.0-0.8-0.7-0.6-0.2-0.3-0.00.00.6
Bone: endosteal perimeter0.10.21.1-0.4-1.0-0.6-0.4-0.4-0.4-0.3-0.10.1-0.00.20.20.7
Epididymis fat weight0.00.10.20.10.30.30.30.40.40.10.30.30.10.10.10.2
Delta time in closed arm before/after self-admin0.10.10.40.1-0.1-0.0-0.00.1-0.10.30.5-0.20.20.60.50.6
Delta time in open arm before/after self-admin1.51.56.22.51.51.31.31.41.41.00.71.20.70.10.3-0.3
Diff in mean of infusions in LGA sessions0.00.00.20.4-0.1-0.2-0.10.00.2-0.1-0.10.2-0.1-0.1-0.10.1
Delay discount exponential model param1.11.22.8-1.7-1.4-1.4-1.1-1.4-1.0-1.2-1.2-0.6-0.8-0.5-0.5-0.3
Extinction: sum of active levers before priming0.30.43.51.90.50.30.20.40.40.10.10.2-0.1-0.2-0.2-0.4
Active lever presses in extinction session 60.00.00.2-0.40.0-0.3-0.2-0.20.1-0.2-0.20.0-0.2-0.2-0.1-0.0
Bone: final force2.03.25.5-2.0-2.4-2.2-2.1-1.8-2.0-1.8-1.6-1.6-1.7-1.5-1.4-0.6
Bone: final moment1.62.64.5-1.8-2.1-2.0-1.9-1.6-1.8-1.7-1.5-1.5-1.5-1.3-1.2-0.5
Food consumed during 24 hour testing period0.10.10.4-0.2-0.5-0.2-0.4-0.6-0.3-0.3-0.5-0.1-0.1-0.1-0.10.1
Glucose0.71.12.91.71.71.31.21.21.21.00.90.60.70.50.4-0.2
Heart weight0.71.13.5-0.0-0.10.60.60.80.51.01.40.81.11.41.51.9
Delay discount hyperbolic model param0.80.92.6-1.6-1.3-1.2-0.9-1.2-0.9-1.0-1.1-0.4-0.6-0.4-0.4-0.1
Intermittent access intake day 1-15 change0.30.71.3-0.7-0.7-1.1-1.0-1.0-0.3-1.1-1.1-0.4-0.8-0.7-0.7-0.3
Intermittent access intake escalation0.30.71.4-0.6-0.6-1.2-1.0-1.1-0.4-1.1-1.1-0.5-0.8-0.8-0.6-0.3
Intermittent access intake escalation 20.10.11.01.00.4-0.2-0.0-0.20.5-0.3-0.40.3-0.2-0.3-0.2-0.1
Intermitt. access day 1 inactive lever presses0.00.11.0-1.0-0.4-0.5-0.4-0.3-0.2-0.2-0.2-0.0-0.00.20.10.2
Intermitt. access day 15 inactive lever presses1.02.03.1-1.3-0.6-1.2-1.3-1.5-1.3-1.3-1.8-1.7-1.3-1.5-1.5-1.7
Intermitt. access escalation Index0.71.02.0-0.1-0.11.21.10.80.11.11.30.71.21.41.21.1
Intermittent access day 1 total infusions1.11.93.6-0.40.91.41.41.41.01.51.91.31.51.51.51.4
Intermittent access day 15 total infusions0.30.40.9-0.60.40.30.40.50.70.50.90.70.60.60.81.0
Intermittent access terminal intake (last 3 days)0.10.20.4-0.00.50.40.40.30.60.40.50.50.40.40.40.4
Intermittent access total infusions0.20.20.5-0.50.70.40.40.50.60.50.70.40.40.30.40.4
Intermittent access day 1 locomotion1.11.53.2-0.90.61.21.21.40.61.41.80.91.31.31.41.2
Intermittent access day 15 total locomotion1.12.14.4-1.80.10.81.01.10.61.31.91.21.51.81.92.1
Intermittent access total locomotion1.21.43.0-0.90.90.91.01.20.91.31.71.01.31.31.41.4
Intermittent access standard deviation0.81.62.9-1.7-0.7-1.3-1.3-1.5-1.0-1.3-1.6-1.3-1.2-1.3-1.2-1.2
Left kidney weight8.238.374.0-8.6-7.5-7.1-6.7-6.6-6.7-6.3-5.9-5.5-5.5-4.6-4.6-2.7
Right kidney weight7.734.962.0-7.9-6.8-6.8-6.5-6.4-6.3-6.1-5.7-5.5-5.3-4.7-4.5-2.8
Cocaine induced anxiety0.10.10.30.30.60.30.20.50.40.30.40.10.10.10.1-0.0
Post-drug Anxiety0.40.42.40.10.80.60.30.5-0.20.1-0.1-0.7-0.4-0.7-0.9-1.5
Baseline Anxiety0.50.63.0-0.7-0.10.30.0-0.1-0.9-0.1-0.7-0.9-0.6-0.9-1.1-1.7
Tail length6.224.344.8-6.0-6.7-6.1-5.6-5.0-5.5-5.0-4.3-4.2-4.5-3.6-3.6-1.9
Length with tail13.458.3101.1-10.1-9.8-9.0-8.4-7.9-8.4-7.8-6.9-6.6-6.9-5.7-5.7-3.3
Length without tail11.035.361.5-7.8-6.9-6.6-6.3-6.4-6.2-6.2-5.9-5.2-5.5-4.8-4.8-3.3
Times rat made contact with spout0.40.51.2-1.0-1.0-1.1-0.7-0.6-0.7-0.7-0.4-0.5-0.6-0.4-0.4-0.0
Lifetime Intake0.10.20.5-0.50.70.40.40.40.50.40.50.20.30.10.20.1
Liver weight, left2.54.27.5-2.7-2.7-2.4-2.3-2.5-2.1-2.2-2.3-1.4-1.6-1.2-1.2-0.6
Liver weight, right3.15.414.7-3.8-2.7-2.5-2.4-2.4-2.5-2.2-2.1-2.1-1.9-1.6-1.6-1.1
Locomotor activity0.30.52.5-0.6-0.9-0.4-0.10.20.10.20.80.70.40.80.91.6
Locomotor testing distance0.10.20.8-0.7-0.7-0.2-0.0-0.20.1-0.10.20.50.20.40.50.9
Locomotor testing rearing0.10.10.30.50.30.50.40.00.50.10.10.60.20.30.30.3
Locomotion in novel chamber1.01.33.6-1.9-1.4-0.10.00.1-0.70.71.00.31.11.41.51.9
Locomotion in novel chamber post-restriction0.40.73.5-0.2-0.9-0.20.00.30.10.50.80.60.81.31.21.9
Fecal boli incidents, locomotor time 10.30.41.4-0.1-1.1-1.2-1.0-0.6-0.6-0.4-0.2-0.3-0.10.00.10.7
Change in fecal boli incidents, locomotor task0.90.92.7-0.6-0.4-0.3-0.5-0.7-0.8-0.9-1.0-0.9-1.1-1.1-1.3-1.6
Time >=10cm from walls, locomotor time 10.91.07.72.81.60.20.40.70.80.20.2-0.1-0.3-0.4-0.4-0.9
Bouts of movement, locomotor time 10.40.41.9-0.5-1.4-0.4-0.9-0.8-0.9-0.4-0.5-0.6-0.2-0.0-0.10.3
Total resting periods, locomotor time 10.30.31.3-0.5-1.1-0.5-0.8-0.7-0.7-0.4-0.4-0.4-0.2-0.1-0.10.4
Rest time, locomotor task time 11.51.95.1-2.3-1.4-1.4-1.6-1.4-1.3-1.3-1.3-1.2-1.1-1.2-1.1-0.7
Distance moved, locomotor task time 11.11.72.91.71.41.11.41.51.51.21.31.41.01.11.10.9
Vertical activity count, locomotor time 10.61.56.72.60.70.90.91.21.21.01.11.30.91.11.01.2
Time >=10cm from walls, locomotor time 21.82.64.0-0.1-0.5-1.9-1.7-1.4-1.3-1.7-1.5-2.0-2.0-1.9-1.9-1.9
Bouts of movement, locomotor time 20.30.41.9-0.9-1.4-0.4-0.7-0.7-0.9-0.4-0.4-0.4-0.1-0.1-0.10.4
Total resting periods, locomotor time 20.40.62.4-1.1-1.6-0.5-0.8-0.8-1.1-0.6-0.6-0.6-0.3-0.4-0.30.1
Rest time, locomotor task time 20.10.10.6-0.20.10.80.40.20.10.30.10.20.30.20.1-0.1
Distance moved, locomotor task time 20.10.10.50.20.7-0.4-0.1-0.00.7-0.2-0.00.2-0.2-0.00.00.2
Vertical activity count, locomotor time 20.30.41.50.3-0.7-1.2-1.0-0.7-0.2-0.5-0.4-0.2-0.4-0.00.10.7
Light reinforcement 10.51.24.02.01.31.11.11.41.11.11.20.80.70.50.50.3
Light reinforcement 20.10.10.20.30.30.30.30.40.20.40.30.20.40.50.30.4
Bone: marrow area0.20.51.7-0.9-1.3-0.9-0.7-0.9-0.7-0.6-0.6-0.1-0.20.00.10.7
Bone: maximum diameter1.22.33.5-1.7-1.9-1.8-1.7-1.6-1.6-1.6-1.5-1.4-1.4-1.3-1.2-0.7
Bone: maximum force1.12.04.1-1.7-2.0-1.9-1.7-1.4-1.5-1.4-1.2-1.1-1.2-1.0-0.9-0.2
Bone: maximum moment0.91.53.3-1.5-1.8-1.7-1.5-1.2-1.4-1.3-1.1-1.0-1.0-0.8-0.8-0.1
Mean time between licks in bursts1.02.53.31.51.81.51.81.71.71.61.61.61.51.51.51.3
Mean num. licks in bursts0.00.00.10.30.20.0-0.00.1-0.0-0.00.0-0.1-0.1-0.2-0.2-0.3
Cd content in liver2.83.14.51.61.11.41.51.81.71.82.11.91.82.01.92.1
Co content in liver0.10.10.70.0-0.4-0.2-0.1-0.40.0-0.0-0.20.30.30.50.50.8
Cu content in liver0.30.40.60.70.80.60.60.30.80.50.40.60.50.70.50.4
Fe content in liver0.20.20.60.2-0.20.10.20.30.20.30.70.50.40.60.60.8
K content in liver0.50.50.7-0.4-0.3-0.5-0.6-0.7-0.6-0.7-0.8-0.8-0.8-0.8-0.9-0.8
Mg content in liver1.31.32.0-1.4-0.9-1.1-1.1-1.3-1.1-1.2-1.3-1.1-1.2-1.1-1.1-1.0
Mn content in liver0.00.00.10.20.20.10.1-0.10.0-0.0-0.2-0.1-0.0-0.1-0.1-0.1
Na content in liver1.31.41.8-1.3-1.3-1.2-1.2-1.1-1.3-1.2-1.2-1.2-1.2-1.1-1.1-1.1
Rb content in liver2.63.15.62.12.42.12.01.92.01.81.61.51.51.31.20.5
Se content in liver2.73.24.6-1.2-1.2-1.7-1.8-1.5-1.8-1.8-1.7-2.1-2.0-2.1-2.1-2.1
Sr content in liver0.20.20.3-0.6-0.6-0.5-0.4-0.6-0.4-0.4-0.6-0.2-0.2-0.1-0.10.1
Zn content in liver2.42.76.4-2.5-2.0-1.9-1.8-2.1-1.5-1.8-1.7-1.2-1.3-0.9-1.0-0.4
Bone: minimum diameter0.10.10.20.50.20.20.30.30.30.30.30.40.30.30.30.5
Time in familiar zone, hab. session 10.30.30.8-0.80.1-0.1-0.2-0.5-0.3-0.5-0.7-0.5-0.5-0.6-0.6-0.9
Time in novel zone, hab. session 10.10.10.60.1-0.5-0.8-0.5-0.3-0.4-0.4-0.2-0.3-0.4-0.2-0.20.0
Total zone transitions, hab. session 12.94.05.02.02.02.02.12.22.12.12.21.91.91.91.91.6
Total locomotion distance, hab. session 10.60.91.51.11.21.01.01.21.01.01.00.70.70.70.70.4
Locomotion velocity, hab. session 11.72.43.81.81.81.71.71.91.61.71.71.31.41.21.20.9
Time in familiar zone, hab. session 20.80.91.8-1.1-0.3-0.4-0.7-0.8-0.8-0.8-0.9-1.0-1.0-1.1-1.1-1.3
Time in novel zone, hab. session 21.51.53.11.70.90.81.11.11.21.11.21.31.21.31.31.3
Total zone transitions, hab. session 20.10.10.4-0.2-0.2-0.00.20.20.20.20.50.40.30.50.50.6
Total locomotion distance, hab. session 20.50.71.00.70.70.70.90.90.80.91.00.90.80.90.80.8
Locomotion velocity, hab. session 20.60.81.10.70.70.80.91.00.90.91.10.90.90.90.90.9
Novel to familiar place preference ratio0.20.20.40.70.30.30.40.40.40.40.50.40.40.40.40.5
Novelty place preference0.40.50.80.90.60.60.70.70.70.70.80.70.70.60.60.6
Time in novel zone, NPP test0.20.20.50.70.40.40.50.50.50.50.50.50.40.50.50.5
Total zone transitions, NPP test0.10.20.50.20.20.00.40.40.40.40.60.60.40.60.50.7
Total locomotion distance, NPP test0.30.40.70.70.60.40.70.80.60.60.90.60.40.50.50.5
Locomotion velocity, NPP test0.60.91.60.90.60.60.91.10.91.01.31.00.91.01.01.1
Intraocular pressure0.40.62.5-1.6-1.1-1.0-0.9-0.9-0.7-0.7-0.4-0.3-0.4-0.0-0.00.5
Delta distance traveled before/after self-admin0.20.32.21.50.1-0.20.10.00.6-0.0-0.10.60.10.20.20.4
Delta ambulatory time before/after self-admin0.50.74.42.10.70.50.60.51.00.40.30.90.50.50.40.4
Parametrial fat weight1.43.35.1-1.7-0.9-1.5-1.7-1.7-1.7-1.7-2.0-2.2-1.9-2.0-2.0-2.2
Pavlov. Cond. lever latency2.53.15.3-2.3-2.3-1.9-1.9-1.9-2.0-1.8-1.8-1.5-1.5-1.3-1.4-0.9
Pavlov. Cond. magazine entry latency0.00.00.2-0.2-0.40.1-0.30.0-0.20.10.1-0.10.1-0.00.10.3
Pavlov. Cond. change in total contacts0.20.20.50.60.70.60.10.50.20.30.1-0.3-0.0-0.4-0.3-0.6
Pavlov. Cond. index score0.20.20.40.60.60.60.40.50.40.50.50.20.40.20.20.2
Pavlov. Cond. latency score0.40.51.01.00.90.90.70.80.70.70.70.40.60.40.40.2
Pavlov. Cond. lever contacts1.51.83.81.82.01.51.51.51.51.41.31.01.10.90.90.4
Pavlov. Cond. magazine entry number0.10.10.20.10.2-0.30.0-0.2-0.0-0.3-0.4-0.1-0.3-0.3-0.3-0.5
Pavlov. Cond. intertrial magazine entries1.51.84.22.01.41.31.41.21.41.31.21.31.31.21.21.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.40.40.50.20.30.20.30.2-0.00.2-0.1-0.0-0.1
Pavlov. Cond. response bias0.10.10.20.20.20.50.20.40.30.40.50.20.40.30.30.5
Pavlov. Cond. lever latency0.50.71.2-1.0-0.7-0.8-0.8-1.1-0.9-0.9-1.1-0.8-0.8-0.7-0.7-0.7
Pavlov. Cond. magazine entry latency1.11.32.41.31.61.41.21.51.21.31.30.80.90.60.60.2
Pavlov. Cond. change in total contacts1.11.82.61.31.01.21.21.41.31.41.61.31.41.41.41.4
Pavlov. Cond. index score1.72.33.31.51.51.51.51.81.61.71.81.41.41.31.31.1
Pavlov. Cond. latency score1.31.72.61.41.41.31.41.61.41.41.61.21.21.11.10.9
Pavlov. Cond. lever contacts0.60.91.51.10.90.90.91.21.01.01.20.90.90.80.80.7
Pavlov. Cond. magazine entry number2.12.53.5-1.7-1.8-1.9-1.7-1.9-1.6-1.8-1.8-1.4-1.5-1.3-1.2-0.9
Pavlov. Cond. intertrial magazine entries0.10.20.9-0.5-0.9-0.7-0.5-0.5-0.5-0.4-0.2-0.1-0.20.00.10.5
Pavlov. Cond. lever-magazine prob. diff.2.02.63.71.61.61.71.61.91.61.81.91.51.51.41.41.2
Pavlov. Cond. response bias1.92.63.91.71.51.61.62.01.61.81.91.51.51.41.41.2
Time in closed arm before self-admin0.30.42.4-1.6-0.6-0.9-0.6-0.50.0-0.6-0.30.2-0.3-0.10.00.5
Time in closed arm after self-admin0.60.62.9-1.1-0.4-0.3-0.10.10.20.20.90.40.51.01.11.7
Time in open arm before self-admin0.20.30.70.2-0.00.60.40.4-0.00.60.80.10.40.80.60.6
Time in open arm after self-admin0.60.75.82.40.70.80.60.50.50.3-0.10.3-0.0-0.4-0.5-0.9
Bone: periosteal estimation0.91.84.0-1.6-2.0-1.7-1.6-1.4-1.5-1.4-1.2-1.1-1.1-0.9-0.8-0.0
Bone: periosteal perimeter0.10.10.6-0.2-0.8-0.6-0.4-0.1-0.4-0.20.1-0.1-0.2-0.0-0.00.4
Bone: post-yield work0.00.00.1-0.3-0.3-0.2-0.1-0.0-0.0-0.00.10.20.10.20.20.4
Progressive ratio test 1 active lever presses0.91.16.7-2.6-1.2-1.1-0.9-0.8-1.0-0.7-0.5-0.7-0.6-0.4-0.4-0.0
Progressive ratio test 1 breakpoint0.81.06.1-2.5-1.2-1.1-0.9-0.9-1.0-0.8-0.5-0.7-0.6-0.5-0.4-0.1
Progressive ratio test 1 inactive lever presses0.40.54.2-2.1-0.9-0.5-0.3-0.3-0.4-0.10.20.10.30.50.60.9
Progressive ratio test 2 active lever presses0.20.21.9-1.4-0.3-0.4-0.2-0.10.1-0.10.30.20.10.30.40.7
Progressive ratio test 2 breakpoint0.20.21.6-1.3-0.2-0.3-0.10.00.2-0.00.40.30.10.30.40.8
Progressive ratio test 2 inactive lever presses0.60.95.6-2.4-1.2-1.3-0.9-0.8-0.5-0.6-0.3-0.2-0.20.30.41.0
Incentive Sensitization - Responses0.20.30.90.60.90.40.50.60.90.40.40.60.30.30.30.3
Incentive Sensitization - Breakpoint0.30.41.10.71.00.60.60.81.10.50.60.80.40.40.50.4
Sum of active levers in priming session hrs 5-61.41.31.9-1.0-0.5-1.0-1.1-1.0-1.0-1.1-1.2-1.3-1.2-1.4-1.3-1.4
Progressive ratio0.10.20.50.20.30.60.40.3-0.10.70.5-0.10.70.70.60.2
Food seeking constrained by brief footshock0.30.41.10.81.00.80.70.30.80.50.10.60.60.50.4-0.0
Seeking ratio, punishment vs. effort0.20.40.7-0.5-0.5-0.7-0.6-0.6-0.1-0.8-0.8-0.1-0.8-0.7-0.7-0.4
Retroperitoneal fat weight0.62.66.1-0.9-0.3-0.9-1.1-1.2-1.3-1.5-1.8-1.9-1.8-2.1-2.2-2.5
Reaction time number correct0.20.31.2-0.0-0.50.00.30.00.30.20.30.90.60.80.81.1
Reaction time mean minus median0.10.21.21.10.00.10.20.80.10.40.70.1-0.00.0-0.00.2
Reaction time mean minus median AUC0.71.73.01.40.91.21.31.71.21.41.71.31.11.21.11.2
Reaction time num false alarms1.31.83.11.20.71.11.21.61.21.41.81.41.31.41.41.3
Reaction time num false alarms AUC0.71.12.10.70.50.81.01.20.91.11.51.11.11.21.21.2
Reaction time trials correct on left0.20.31.2-0.0-0.50.00.30.00.30.20.30.90.60.80.81.1
Reaction time trials on left0.20.31.2-0.0-0.50.00.30.10.30.30.30.90.60.80.81.1
Reaction time mean0.91.53.61.91.71.71.41.61.11.21.20.60.60.30.2-0.3
Reaction time mean AUC1.21.94.52.11.91.81.61.81.31.31.40.80.80.50.4-0.1
Median of all reaction times1.21.74.31.92.12.01.61.61.31.21.10.60.70.30.2-0.5
Reaction time omissions0.40.51.00.60.90.90.81.00.60.91.00.40.50.50.50.4
Reaction time false alarm rate0.50.61.60.50.60.70.71.10.60.91.30.60.70.80.80.6
Reaction time premature initiation rate0.10.20.50.7-0.40.40.20.5-0.30.50.6-0.00.30.30.40.4
Reaction time premature initiations0.20.30.60.5-0.60.40.30.4-0.20.50.70.40.60.60.70.8
Std. dev. reaction times0.20.41.30.90.70.90.71.10.50.71.00.30.20.20.1-0.0
Reaction time trials completed0.20.31.2-0.0-0.50.00.30.10.30.30.30.90.60.80.81.1
Reaction time trials AUC0.30.51.60.3-0.20.30.50.30.60.50.51.10.91.01.01.3
Run reversals in cocaine runway, females0.30.30.80.90.90.70.60.50.60.50.20.30.30.10.2-0.1
Run reversals in cocaine runway, males2.32.34.31.20.81.11.21.31.51.51.51.71.71.91.92.1
Latency to leave start box in cocaine runway0.40.41.1-0.4-0.3-0.3-0.5-0.4-0.6-0.6-0.7-0.8-0.6-0.8-0.9-1.1
Latency to leave start box in cocaine runway, F1.72.03.1-0.5-0.6-1.2-1.4-1.4-1.1-1.5-1.7-1.6-1.5-1.6-1.7-1.8
Latency to leave start box in cocaine runway, M0.70.61.0-0.3-0.00.90.90.90.30.91.00.81.00.90.90.8
Std. dev. time between licks in bursts0.50.62.00.40.10.30.50.80.60.71.00.90.81.01.01.4
Total sessions with >9 infusions0.30.42.7-1.6-0.2-0.2-0.3-0.3-0.5-0.3-0.4-0.6-0.2-0.4-0.4-0.6
Short access day 1 total inactive lever presses0.70.93.2-1.8-1.1-0.8-0.8-1.0-1.2-0.8-1.0-0.9-0.6-0.6-0.6-0.6
Short access day 10 total inactive lever presses2.15.18.0-2.8-2.0-2.4-2.3-2.6-2.2-2.3-2.8-2.1-2.1-1.9-1.9-1.7
Short access day 1 total infusions0.10.10.5-0.60.40.40.20.0-0.10.1-0.2-0.2-0.0-0.2-0.3-0.7
Short access day 10 total infusions0.10.10.70.30.80.40.40.30.60.30.10.20.20.10.0-0.2
Short access total infusions0.20.31.0-0.90.20.0-0.1-0.2-0.3-0.2-0.4-0.6-0.3-0.7-0.6-1.0
Short access day 1 locomotion0.50.61.4-0.60.20.90.80.90.20.91.20.40.80.90.80.6
Short access day 10 total locomotion0.20.44.5-2.1-0.6-0.00.0-0.1-0.50.10.10.00.40.50.40.4
Short access total locomotion0.10.20.7-0.80.20.40.40.5-0.10.50.5-0.00.40.30.2-0.1
One hour access (0.3 mA shock)1.21.43.40.60.50.40.80.91.50.71.21.81.01.31.41.8
Compulsive drug intake2.42.98.02.81.91.91.81.71.81.61.51.61.41.31.20.8
One hour access (shock baseline)0.20.42.0-1.4-0.7-0.7-0.3-0.10.1-0.10.40.40.10.40.51.1
Social response proportion2.73.16.6-2.4-2.6-2.1-2.1-1.6-2.2-1.6-1.1-1.7-1.4-1.2-1.1-0.4
Social responses0.40.51.8-1.3-1.4-0.8-0.6-0.2-0.6-0.10.30.00.20.50.51.1
Social time2.94.05.62.12.02.22.12.42.12.12.31.91.91.61.71.2
Soleus weight0.61.64.5-1.3-2.1-1.8-1.6-1.4-1.5-1.3-1.1-0.9-0.9-0.7-0.50.4
Bone: stiffness0.10.10.4-0.2-0.7-0.5-0.30.1-0.2-0.10.30.0-0.10.10.10.6
Tibialis anterior weight5.317.929.0-5.2-5.4-5.2-4.9-4.2-4.6-4.3-3.8-3.8-3.9-3.4-3.3-1.8
Time to tail flick, vehicle, before self-admin0.30.31.51.20.60.2-0.00.30.0-0.0-0.0-0.5-0.4-0.6-0.6-0.9
Time to tail flick, vehicle, after self-admin0.10.20.40.00.60.40.40.40.70.30.50.40.20.30.30.4
Time to tail flick, test, before self-admin0.80.81.5-0.9-1.1-1.2-1.0-1.2-0.8-1.0-1.1-0.7-0.9-0.6-0.7-0.3
Time to tail flick, test, after self-admin0.20.20.7-0.8-0.40.2-0.0-0.1-0.7-0.2-0.3-0.5-0.3-0.4-0.5-0.7
Delta time to tail flick, vehicle, before/after SA0.70.71.40.50.90.70.80.71.20.70.81.10.70.80.80.9
Delta time to tail flick, test, before/after SA0.40.41.20.50.81.10.80.80.40.60.60.40.50.30.3-0.1
Tibia length6.217.228.0-5.3-4.4-4.5-4.4-4.2-4.2-4.3-4.1-3.9-4.0-3.7-3.6-2.8
Ambulatory time before self-admin0.40.61.20.30.90.90.80.90.70.81.10.60.70.60.70.7
Ambulatory time after self-admin1.51.75.42.31.71.11.11.21.81.01.11.30.90.90.90.9
Bone: tissue strength0.10.10.4-0.5-0.1-0.2-0.2-0.5-0.1-0.3-0.6-0.1-0.2-0.2-0.2-0.2
Total heroin consumption3.74.39.52.53.12.22.12.22.62.02.11.61.61.51.41.0
Bone: trabecular number2.54.26.7-2.5-2.6-2.4-2.3-2.3-2.2-2.1-2.1-1.7-1.7-1.5-1.4-1.1
Bone: trabecular spacing1.82.44.62.12.11.91.81.61.71.61.41.31.41.11.10.6
Bone: trabecular thickness3.03.86.3-2.3-2.5-2.4-2.2-2.1-2.1-2.0-1.9-1.7-1.7-1.5-1.4-0.7
Bone: trabecular tissue density0.10.10.30.2-0.0-0.3-0.30.4-0.2-0.10.3-0.5-0.5-0.5-0.5-0.4
Water consumed over 24 hours1.21.64.0-1.7-2.0-1.6-1.5-1.5-1.4-1.3-1.2-0.8-0.9-0.6-0.6-0.0
Number of responses in last shaping day0.10.10.4-0.60.50.30.10.20.10.20.2-0.30.10.10.1-0.1