LOC134480887

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC134480887	0.17	0.08	4.1e-06	0.03	0.04	0.04	0.03	1.5e-04	2.2e-05	2.6e-05	1.1e-04
2	pVTA	gene expression	LOC134480887	0.17	0.08	3.1e-06	0.09	0.08	0.07	0.08	2.1e-07	1.1e-06	4.7e-06	6.6e-07
3	NAcc	gene expression	LOC134480887	0.05	0.03	1.7e-03	0.02	0.01	0.02	0.02	7.2e-04	4.1e-03	8.9e-04	6.2e-04
4	Adipose	gene expression	LOC134480887	0.11	0.05	4.5e-12	0.09	0.11	0.1	0.1	5.7e-10	2.5e-12	1.1e-11	1.4e-11
5	Brain	gene expression	LOC134480887	0.35	0.1	0.0e+00	0.23	0.24	0.24	0.24	1.7e-21	3.0e-22	5.1e-22	1.4e-22
6	Eye	intron excision ratio	chr10_89714132_89715351	0.31	0.15	2.6e-03	0.04	0.18	0.2	0.18	7.3e-02	1.2e-03	6.1e-04	1.1e-03
7	Eye	gene expression	LOC134480887	0.7	0.14	5.3e-07	0.24	0.14	0.16	0.22	1.5e-04	3.9e-03	2.0e-03	2.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	1.1	1.9	8.8	-0.6	-0.6	-0.0	-3.0	-0.9	-1.0	1.3
Area under the delay curve	0.5	0.5	1.0	1.0	0.9	0.7	-0.4	0.8	0.4	-0.7
BMI with tail	2.0	6.8	13.1	2.4	3.5	2.9	1.9	3.6	0.4	-2.1
BMI without tail	1.9	5.8	11.1	2.9	3.2	2.8	0.7	3.3	-1.3	-0.1
Body weight	3.0	13.0	24.0	4.5	4.9	4.6	-0.5	4.7	-1.9	-0.3
Weight adjusted by age	0.4	0.6	1.2	0.9	1.0	1.1	0.1	0.8	0.0	-0.6
Bone surface	1.9	3.5	13.1	1.1	1.4	1.8	-3.6	0.7	-1.8	1.2
Bone volume	1.6	2.9	12.6	0.7	0.9	1.3	-3.5	0.2	-1.8	1.3
Breakpoint value in progressive ratio session	0.0	0.0	0.1	0.2	-0.0	-0.3	0.0	0.1	-0.1	-0.3
Number of licking bursts	0.8	1.3	3.1	1.8	1.3	1.2	0.3	1.4	0.2	-0.8
Context. condit. distance diff. score	0.8	1.0	2.9	-0.2	0.2	0.1	1.5	0.3	1.2	-1.7
Locomotion velocity, session 1	0.7	0.7	2.6	0.7	-0.1	-0.1	-1.6	-0.3	-1.1	0.8
Locomotion distance, session 1	0.3	0.4	1.2	0.4	-0.3	-0.0	-1.1	-0.2	-1.0	0.8
Locomotion velocity, session 2	1.2	1.4	2.3	-0.9	-1.5	-1.3	-1.3	-1.5	-0.4	0.9
Locomotion distance, session 2	0.2	0.3	0.6	-0.0	-0.6	-0.7	-0.2	-0.5	-0.8	0.6
Locomotion velocity, session 3	0.4	0.4	1.1	-0.5	-0.6	-0.5	-1.0	-0.8	0.4	-0.4
Locomotion distance, session 3	0.3	0.3	0.9	0.1	0.0	0.1	-0.8	-0.2	0.8	-0.9
Stereotopy head waving bouts, day 3	1.3	1.5	3.1	-1.4	-1.4	-1.5	-1.1	-1.8	0.1	0.5
Stereotopy head waving duration, day 3	0.6	0.8	1.4	-0.9	-1.1	-1.2	-0.2	-1.2	-0.2	0.8
Locomotion velocity, session 7	0.5	0.5	1.1	-0.6	-0.7	-0.7	-0.4	-0.9	1.1	-0.5
Locomotion distance, session 7	0.2	0.2	0.7	-0.4	-0.3	-0.5	0.2	-0.4	0.8	-0.3
Stereotopy head waving bouts, day 7	1.3	1.4	2.5	-1.5	-1.5	-1.2	-0.8	-1.6	0.1	0.8
Stereotopy head waving duration, day 7	2.0	2.4	4.6	-1.7	-2.1	-1.9	-0.3	-2.0	0.2	1.1
Locomotion velocity, session 8	0.5	0.6	1.5	1.2	0.9	0.6	0.6	0.9	-0.5	-0.2
Locomotion distance, session 8	0.3	0.4	1.0	-0.3	-0.7	-0.7	1.0	-0.4	0.2	-0.6
Degree of sensitization distance	0.5	0.5	1.0	0.7	0.6	0.4	1.0	0.8	-0.5	0.6
Degree of sensitization stereotypy	1.0	1.0	2.2	-1.5	-1.4	-1.1	-0.1	-1.3	0.4	0.5
Conditioned locomotion	0.2	0.2	0.4	-0.4	-0.6	-0.6	0.5	-0.4	-0.1	0.3
Cocaine response after cond. corrected	0.5	0.6	1.6	-0.4	0.6	0.7	-0.7	0.2	1.1	-1.3
Cocaine response after cond. not corrected	0.7	0.8	2.3	-0.8	0.3	0.4	-1.5	-0.3	1.1	-1.2
Cocaine response before conditioning	0.6	0.8	2.4	-0.5	-0.7	-0.6	-1.5	-0.8	-0.7	0.9
Saline control response	1.2	1.7	2.2	1.5	1.1	0.6	1.5	1.2	-1.5	1.4
Bone: connectivity density	1.2	1.9	7.8	-0.4	-0.4	0.1	-2.8	-0.7	-1.3	1.7
Bone: cortical apparent density	4.9	6.7	11.6	-3.2	-3.4	-3.4	-0.1	-3.4	1.6	0.3
Bone: cortical area	0.8	1.2	5.8	0.1	1.0	1.2	-2.4	0.3	-0.4	0.1
Bone: cortical porosity	6.6	7.1	11.6	2.4	3.4	3.4	-3.3	2.4	-2.0	0.2
Bone: cortical porosity	6.7	7.2	13.1	2.7	3.6	3.6	-2.7	2.7	-1.7	-0.4
Bone: cortical thickness	2.4	3.9	8.9	-3.0	-1.9	-1.4	-1.6	-2.3	2.2	-0.9
Bone: cortical thickness	2.9	3.4	7.2	-2.7	-1.9	-1.7	-1.1	-2.3	1.8	-0.6
Bone: cortical tissue density	4.8	6.5	11.4	-3.1	-3.4	-3.3	-0.1	-3.3	1.5	0.4
Condit. Reinf. active minus inactive responses	0.8	0.8	1.7	1.1	0.8	0.8	-0.8	0.7	-1.3	0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.3	0.4	0.4	-0.1	0.4	-0.4	0.4
Condit. Reinf. active responses	0.8	1.0	2.7	1.1	0.6	0.6	-1.1	0.5	-1.6	0.9
Condit. Reinf. inactive responses	0.4	0.5	1.4	0.3	-0.1	-0.2	-1.2	-0.3	-1.1	0.7
Incentive salience index mean	0.7	0.9	2.2	0.8	0.5	0.7	-1.5	0.4	-1.4	0.8
Condit. Reinf. lever presses	0.4	0.6	2.6	-0.0	-0.3	-0.0	-1.6	-0.4	-1.0	0.6
Condit. Reinf. active minus inactive responses	1.2	1.6	6.2	0.6	0.7	0.8	-2.5	0.3	-1.6	0.9
Condit. Reinf. active-inactive response ratio	1.1	1.2	4.0	0.9	0.9	1.0	-2.0	0.7	-1.2	0.4
Condit. Reinf. active responses	1.6	2.2	5.7	0.9	0.6	0.6	-2.3	0.3	-2.4	1.7
Condit. Reinf. inactive responses	1.4	1.8	5.8	0.0	-0.7	-0.7	-0.9	-0.7	-2.2	2.4
Condit. Reinf. lever presses	0.4	0.6	1.7	-0.1	-0.2	-0.0	-1.3	-0.2	-1.1	1.1
Condit. Reinf. lever reinforcers received	1.2	1.7	5.3	0.6	0.4	0.4	-2.3	0.1	-2.0	1.4
Conditioned reinforcement - actives	0.2	0.4	1.2	1.1	0.2	0.5	0.7	0.7	-0.5	0.3
Conditioned reinforcement - inactives	0.8	1.1	2.2	0.9	1.5	1.5	-0.4	1.4	-0.7	0.2
Conditioned locomotion	1.4	1.8	4.3	2.1	1.5	1.7	-0.2	1.5	-1.0	0.1
Patch foraging indifference point 0 sec	1.0	1.8	5.7	0.2	-0.2	-0.3	-1.1	-0.5	-2.3	2.4
Patch foraging indifference point AUC	0.5	0.8	1.3	1.1	1.0	0.8	0.5	1.1	-0.6	0.7
Delay disc. indifference point, 0s delay	0.2	0.2	0.5	0.1	-0.4	-0.6	-0.0	-0.2	-0.3	0.7
Delay disc. indifference point, 16s delay	1.5	1.6	3.0	1.3	1.7	1.4	-0.2	1.3	1.0	-1.4
Delay disc. indifference point, 2s delay	0.8	0.9	3.0	0.6	-0.1	0.1	-1.7	-0.1	-1.2	1.1
Delay disc. indifference point, 24s delay	1.4	1.6	3.3	1.8	1.8	1.4	-0.3	1.5	-0.5	-0.3
Delay disc. indifference point, 4s delay	0.4	0.4	1.0	0.6	0.8	0.6	-0.7	0.4	0.4	-1.0
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	-0.1	-0.2	-0.4	-0.6	-0.3	0.7	-0.5
Indifference point function ln k	0.5	0.9	3.4	-1.0	-0.7	-0.4	-1.8	-1.0	-0.4	0.3
Indifference point function log k	0.5	0.9	3.4	-1.0	-0.7	-0.4	-1.8	-1.0	-0.4	0.3
Patch foraging total patch changes 0 sec	0.9	1.7	5.7	0.4	0.1	0.1	-1.3	-0.2	-2.4	2.2
Patch foraging total patch changes 12 sec	1.6	2.1	7.8	0.7	-0.4	-0.6	0.2	-0.3	-2.5	2.8
Patch foraging total patch changes 18 sec	0.4	0.6	1.1	0.9	1.1	0.9	0.1	0.8	-0.7	0.4
Patch foraging total patch changes 24 sec	0.8	1.4	4.0	0.6	0.3	0.1	-1.2	-0.2	-1.9	2.0
Patch foraging total patch changes 6 sec	0.5	0.7	2.1	0.6	0.4	0.4	-0.6	0.2	-1.3	1.4
Patch foraging time to switch 0 sec	0.1	0.2	0.5	0.4	0.2	0.1	0.2	0.2	0.7	-0.7
Patch foraging water rate 0 sec	0.2	0.5	1.4	0.4	0.3	0.6	-0.8	0.2	-1.2	0.8
Patch foraging water rate 12 sec	0.4	0.8	2.2	-0.6	0.4	0.6	-0.9	-0.1	1.4	-1.5
Patch foraging water rate 18 sec	0.8	1.3	2.2	-1.4	-1.2	-1.0	-1.4	-1.5	-0.3	0.7
Patch foraging water rate 24 sec	1.2	1.7	3.9	-2.0	-1.6	-1.3	-0.2	-1.7	0.9	-0.4
Patch foraging water rate 6 sec	0.3	0.5	2.4	-0.5	-0.1	0.2	-1.5	-0.3	-0.7	0.4
Seeking ratio, delayed vs. immediate footshock	2.4	3.0	5.1	2.2	1.9	1.7	1.5	2.3	0.8	-1.1
Distance traveled before self-admin	0.3	0.3	1.1	0.0	0.4	0.4	-0.9	0.2	0.5	-1.0
Distance traveled after self-admin	0.6	0.7	2.2	-0.5	-0.5	-0.3	1.0	0.2	1.1	-1.5
Extensor digitorum longus weight	1.5	5.9	22.0	1.6	1.3	0.7	4.7	2.1	2.2	-2.4
Bone: elastic displacement	1.1	1.2	2.3	-1.5	-0.9	-0.5	-0.8	-1.0	1.3	-1.3
Bone: elastic work	0.4	0.5	2.8	-0.6	-0.1	0.3	-1.7	-0.2	0.2	-0.7
Bone: endosteal estimation	4.9	10.8	16.8	4.1	4.0	3.8	-2.2	3.4	-3.3	1.2
Bone: endosteal perimeter	7.6	16.1	27.2	5.0	5.2	4.9	-1.9	4.5	-3.4	0.8
Epididymis fat weight	0.2	0.7	1.5	1.0	1.1	0.8	0.2	1.2	-0.5	0.4
Delta time in closed arm before/after self-admin	0.8	0.7	2.4	-0.6	0.4	-0.0	-0.3	-0.1	1.5	-1.5
Delta time in open arm before/after self-admin	1.3	1.3	3.7	0.2	-1.0	-1.0	1.0	-0.3	-1.4	1.9
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.2	0.0	-0.3	0.4	0.1	-0.6	0.4
Delay discount exponential model param	0.7	0.7	1.5	-1.2	-1.1	-0.8	0.4	-1.0	-0.3	0.7
Extinction: sum of active levers before priming	0.2	0.2	0.7	0.1	-0.7	-0.5	0.9	-0.2	-0.0	-0.3
Active lever presses in extinction session 6	2.1	2.1	4.3	2.1	1.7	1.6	-0.4	1.8	-1.2	0.1
Bone: final force	0.6	0.9	4.1	-1.0	0.1	0.1	-2.0	-0.6	-0.2	0.9
Bone: final moment	0.8	1.2	5.5	-1.2	-0.0	0.0	-2.4	-0.8	-0.3	0.9
Food consumed during 24 hour testing period	2.0	2.8	4.9	2.2	2.1	1.8	0.4	1.9	-1.4	1.0
Glucose	0.8	1.2	4.2	-0.6	-0.1	-0.2	0.9	-0.2	2.0	-1.7
Heart weight	1.5	2.3	4.0	1.2	1.9	2.0	0.4	1.9	0.8	-1.8
Delay discount hyperbolic model param	0.6	0.7	1.6	-1.3	-1.0	-0.8	0.6	-0.9	-0.0	0.5
Intermittent access intake day 1-15 change	0.3	0.6	1.4	0.6	0.3	0.6	1.0	0.4	0.7	-1.2
Intermittent access intake escalation	0.3	0.6	1.7	0.5	0.4	0.8	1.0	0.4	0.7	-1.3
Intermittent access intake escalation 2	0.5	0.6	1.3	0.6	0.6	0.8	0.8	0.6	0.4	-1.2
Intermitt. access day 1 inactive lever presses	0.6	2.5	4.1	2.0	1.6	1.6	-1.3	1.6	-1.5	1.0
Intermitt. access day 15 inactive lever presses	1.4	2.8	7.2	1.1	0.7	1.1	-1.8	0.6	-2.7	2.5
Intermitt. access escalation Index	0.6	0.9	2.2	-0.2	0.7	0.2	1.1	0.5	1.4	-1.5
Intermittent access day 1 total infusions	0.4	0.7	1.9	1.1	0.7	0.5	-0.3	0.5	-0.9	1.4
Intermittent access day 15 total infusions	1.2	1.8	3.8	1.9	1.6	1.5	1.1	1.5	-0.4	0.0
Intermittent access terminal intake (last 3 days)	2.0	2.6	5.5	2.3	2.0	1.8	0.7	1.7	-1.2	0.8
Intermittent access total infusions	1.8	2.1	5.1	2.3	1.6	1.3	0.7	1.5	-1.1	1.2
Intermittent access day 1 locomotion	2.6	3.3	6.9	2.6	2.2	2.1	-0.6	1.9	-1.5	0.8
Intermittent access day 15 total locomotion	1.5	2.7	6.5	2.5	1.7	1.7	0.8	1.8	-1.4	0.7
Intermittent access total locomotion	3.6	4.3	10.0	3.2	2.2	2.2	-0.3	2.1	-2.0	1.2
Intermittent access standard deviation	0.2	0.3	1.1	1.1	0.0	0.4	0.2	0.5	-0.7	0.5
Left kidney weight	0.1	0.5	1.3	-0.7	0.2	0.3	-1.1	-0.1	0.6	-0.9
Right kidney weight	0.2	0.8	1.3	0.1	0.9	1.0	-1.1	0.6	0.8	-1.1
Cocaine induced anxiety	1.0	1.5	5.2	-0.9	-0.1	-0.2	-0.2	-0.5	2.0	-2.3
Post-drug Anxiety	0.8	0.8	3.8	-0.1	0.7	0.7	-0.3	0.5	0.8	-2.0
Baseline Anxiety	1.5	1.8	2.8	1.5	1.4	1.4	-0.1	1.7	-1.7	0.7
Tail length	1.1	4.5	9.0	1.9	1.1	1.2	-3.0	0.6	-2.9	2.8
Length with tail	1.1	4.9	8.1	2.9	2.1	2.3	-2.0	1.9	-2.4	1.7
Length without tail	0.5	1.7	3.2	1.7	1.7	1.8	-0.1	1.6	-0.1	-0.6
Times rat made contact with spout	0.3	0.3	0.7	0.6	0.8	0.6	-0.1	0.6	0.0	-0.5
Lifetime Intake	1.4	1.7	4.5	2.1	1.3	1.3	0.3	1.3	-1.1	1.1
Liver weight, left	1.3	2.1	2.9	1.5	1.7	1.7	-1.7	1.3	-1.4	0.7
Liver weight, right	0.7	1.1	2.9	-1.2	-0.6	-0.5	-1.7	-1.0	1.2	-0.8
Locomotor activity	0.5	0.8	2.4	1.1	0.4	0.6	0.0	0.8	-1.6	0.8
Locomotor testing distance	0.5	0.9	3.3	1.0	0.6	0.7	-0.0	0.8	-1.8	0.9
Locomotor testing rearing	0.4	0.7	1.8	0.8	0.6	0.4	1.3	0.8	-1.3	0.2
Locomotion in novel chamber	1.8	2.3	4.8	1.6	2.2	2.0	-0.8	1.4	-0.9	-0.9
Locomotion in novel chamber post-restriction	0.5	0.8	1.6	1.0	1.0	0.5	-0.7	0.8	-1.3	0.8
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	-0.1	0.1	-0.1	0.4	-0.0	0.5	-0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.2	0.2	0.3	0.0	0.3	0.6	-0.4
Time >=10cm from walls, locomotor time 1	1.5	1.6	4.5	-1.7	-0.4	-0.6	0.8	-0.5	1.5	-2.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	-0.3	-0.5	0.0	-0.4	0.5	0.3
Total resting periods, locomotor time 1	0.0	0.1	0.2	-0.2	-0.1	-0.1	-0.2	-0.2	0.4	0.2
Rest time, locomotor task time 1	0.7	0.8	1.6	-1.0	-1.3	-1.0	-0.6	-1.3	0.4	0.0
Distance moved, locomotor task time 1	1.0	1.5	2.6	1.5	1.5	1.6	0.3	1.6	-0.2	-0.6
Vertical activity count, locomotor time 1	0.4	0.9	1.7	1.0	1.3	1.3	-0.4	1.2	-0.3	-0.5
Time >=10cm from walls, locomotor time 2	0.4	0.6	1.9	0.1	0.9	0.9	-0.5	0.6	0.1	-1.4
Bouts of movement, locomotor time 2	0.2	0.4	1.3	-1.1	-0.6	-0.5	-0.4	-0.8	0.1	-0.0
Total resting periods, locomotor time 2	0.4	0.6	2.0	-1.4	-0.8	-0.7	-0.2	-1.0	0.5	-0.3
Rest time, locomotor task time 2	0.5	0.7	1.6	-0.8	-0.4	-0.6	0.7	-0.5	1.3	-1.1
Distance moved, locomotor task time 2	0.2	0.3	0.5	0.7	0.4	0.7	-0.3	0.5	-0.5	-0.1
Vertical activity count, locomotor time 2	0.5	0.7	2.2	0.4	-0.0	0.3	-1.1	0.1	-1.5	1.0
Light reinforcement 1	0.9	2.1	6.5	-0.0	-1.2	-0.9	-1.0	-1.1	-2.0	2.5
Light reinforcement 2	1.3	2.1	4.0	-0.7	-1.3	-1.1	-1.9	-1.3	-1.3	2.0
Bone: marrow area	4.9	10.6	16.4	4.0	4.0	3.8	-2.2	3.3	-3.3	1.3
Bone: maximum diameter	2.0	3.7	6.0	1.8	2.3	2.3	-2.4	1.6	-1.7	0.7
Bone: maximum force	0.7	1.3	3.9	0.3	1.3	1.4	-2.0	0.7	-0.6	0.7
Bone: maximum moment	0.7	1.3	5.5	0.1	1.1	1.2	-2.3	0.4	-0.6	0.7
Mean time between licks in bursts	1.0	2.5	3.9	1.7	1.9	1.9	0.9	2.0	0.9	-1.2
Mean num. licks in bursts	0.3	0.5	1.4	-1.2	-0.7	-0.7	-0.3	-0.9	-0.1	0.4
Cd content in liver	1.9	2.1	5.1	-1.2	-1.4	-1.7	2.3	-1.0	1.4	-0.9
Co content in liver	0.3	0.3	1.3	0.1	-0.3	-0.5	1.1	0.2	0.1	-0.7
Cu content in liver	0.3	0.4	0.9	1.0	0.5	0.5	-0.8	0.5	-0.7	0.3
Fe content in liver	0.8	0.9	1.7	-1.1	-1.2	-1.3	-0.5	-1.3	0.2	0.6
K content in liver	1.2	1.2	1.8	-1.0	-1.3	-1.0	-1.2	-1.3	-0.4	1.1
Mg content in liver	3.8	3.9	7.4	-2.2	-2.7	-2.6	-0.3	-2.6	0.2	1.3
Mn content in liver	5.4	6.0	9.7	-2.6	-3.1	-2.6	-2.0	-3.1	-0.6	2.2
Na content in liver	0.4	0.4	0.8	-0.1	-0.7	-0.6	-0.4	-0.5	-0.9	0.9
Rb content in liver	1.9	2.2	4.2	-1.7	-2.0	-2.0	0.4	-1.8	0.5	0.8
Se content in liver	0.8	1.0	2.1	-0.7	-0.9	-0.9	1.2	-0.6	1.4	-0.9
Sr content in liver	0.8	0.7	1.4	0.6	0.9	1.0	-0.6	0.6	0.7	-1.2
Zn content in liver	0.5	0.5	0.9	-0.9	-0.5	-0.6	0.2	-0.6	0.9	-1.0
Bone: minimum diameter	6.2	11.2	17.9	4.0	4.2	4.2	-2.7	3.5	-2.6	0.6
Time in familiar zone, hab. session 1	0.7	0.7	1.7	1.2	0.8	0.5	1.3	0.9	-0.1	-0.2
Time in novel zone, hab. session 1	0.8	0.8	2.2	-1.5	-0.8	-0.4	-1.1	-0.9	0.5	-0.1
Total zone transitions, hab. session 1	0.3	0.5	0.9	0.9	0.5	0.5	0.7	0.7	0.4	-0.8
Total locomotion distance, hab. session 1	0.6	0.8	2.4	0.8	0.5	0.8	-1.5	0.4	-1.1	0.7
Locomotion velocity, hab. session 1	0.9	1.3	2.5	1.3	0.7	0.9	-1.5	0.6	-1.6	1.1
Time in familiar zone, hab. session 2	0.8	0.8	2.7	1.0	0.8	0.4	1.7	1.0	-0.3	0.1
Time in novel zone, hab. session 2	1.8	1.8	4.8	-1.8	-1.3	-0.7	-2.2	-1.6	0.5	-0.1
Total zone transitions, hab. session 2	0.2	0.3	1.2	0.5	-0.1	-0.2	1.1	0.2	0.3	-0.6
Total locomotion distance, hab. session 2	0.2	0.2	0.6	0.6	-0.2	-0.3	0.1	-0.1	-0.6	0.7
Locomotion velocity, hab. session 2	0.1	0.2	0.5	0.7	-0.1	-0.3	0.2	0.0	-0.6	0.6
Novel to familiar place preference ratio	0.4	0.4	0.9	0.4	0.8	0.9	-0.6	0.7	-0.5	-0.2
Novelty place preference	0.2	0.2	0.5	0.2	0.6	0.7	-0.6	0.5	-0.4	-0.3
Time in novel zone, NPP test	0.2	0.2	0.5	-0.2	0.4	0.6	-0.7	0.2	-0.3	-0.3
Total zone transitions, NPP test	0.1	0.2	0.5	0.0	-0.6	-0.7	-0.0	-0.6	-0.3	0.3
Total locomotion distance, NPP test	0.4	0.5	1.8	0.1	-0.3	-0.2	-1.3	-0.5	-1.0	0.7
Locomotion velocity, NPP test	0.2	0.3	0.9	0.7	0.1	0.1	-0.8	0.0	-1.0	0.5
Intraocular pressure	1.1	1.6	3.3	1.4	1.8	1.4	0.6	1.7	-0.0	-0.5
Delta distance traveled before/after self-admin	0.5	0.5	1.9	-0.6	-0.7	-0.7	1.4	-0.0	0.4	-0.1
Delta ambulatory time before/after self-admin	0.3	0.3	1.6	-0.2	-0.4	-0.4	1.3	0.3	0.3	-0.1
Parametrial fat weight	0.4	0.8	4.7	0.0	0.1	0.0	-2.2	-0.2	-1.0	0.3
Pavlov. Cond. lever latency	1.4	1.8	3.8	-1.4	-1.4	-1.7	1.9	-1.2	1.0	0.1
Pavlov. Cond. magazine entry latency	1.6	2.0	6.4	0.1	-0.0	0.3	-2.5	-0.4	-2.1	1.8
Pavlov. Cond. change in total contacts	1.7	1.8	4.6	0.9	0.5	0.7	-2.1	0.3	-2.1	1.4
Pavlov. Cond. index score	1.2	1.5	5.2	0.5	0.5	0.9	-2.3	0.3	-1.7	1.0
Pavlov. Cond. latency score	1.0	1.3	3.7	0.7	0.7	1.1	-1.9	0.5	-1.5	0.6
Pavlov. Cond. lever contacts	1.4	1.7	3.6	1.3	1.2	1.5	-1.9	1.0	-1.2	-0.1
Pavlov. Cond. magazine entry number	1.9	2.3	5.5	0.5	0.7	0.5	2.4	1.0	2.1	-2.1
Pavlov. Cond. intertrial magazine entries	1.2	1.4	3.4	1.9	1.1	0.9	0.9	1.4	-1.2	0.3
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.8	6.8	0.5	0.5	1.0	-2.6	0.3	-1.8	1.1
Pavlov. Cond. response bias	2.3	2.9	12.4	0.1	0.0	0.4	-3.5	-0.4	-2.2	1.6
Pavlov. Cond. lever latency	0.3	0.5	1.9	0.3	0.3	0.1	0.6	0.3	0.8	-1.4
Pavlov. Cond. magazine entry latency	0.4	0.5	1.0	-0.7	-0.6	-0.5	0.9	-0.4	1.0	-0.8
Pavlov. Cond. change in total contacts	0.2	0.4	1.1	0.4	-0.2	-0.3	0.5	0.1	-1.0	1.0
Pavlov. Cond. index score	0.0	0.0	0.2	-0.2	-0.2	-0.1	-0.0	-0.1	-0.2	0.4
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.2	-0.1	-0.1	0.3
Pavlov. Cond. lever contacts	0.3	0.5	1.7	-0.4	-0.5	-0.3	-0.5	-0.5	-0.8	1.3
Pavlov. Cond. magazine entry number	1.2	1.4	2.4	1.5	1.2	1.1	-0.8	1.0	-1.5	1.1
Pavlov. Cond. intertrial magazine entries	4.5	6.8	10.7	3.0	2.5	2.5	-2.4	2.1	-3.3	2.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.0	-0.2	-0.0	0.4
Pavlov. Cond. response bias	0.3	0.3	0.5	-0.7	-0.7	-0.7	-0.1	-0.7	-0.2	0.6
Time in closed arm before self-admin	0.4	0.6	1.1	-0.7	-0.9	-1.0	0.4	-0.7	0.0	1.1
Time in closed arm after self-admin	1.0	1.1	4.2	-1.2	-0.3	-0.8	0.7	-0.5	2.1	-0.7
Time in open arm before self-admin	2.2	2.4	8.7	0.0	1.3	1.4	0.1	0.9	2.0	-3.0
Time in open arm after self-admin	1.0	1.1	2.1	1.4	1.0	1.1	0.6	1.5	-1.0	-0.4
Bone: periosteal estimation	3.3	7.0	9.9	2.7	3.1	3.1	-3.1	2.3	-2.5	1.1
Bone: periosteal perimeter	3.6	6.1	11.5	2.6	3.4	3.3	-2.3	2.6	-1.2	-0.2
Bone: post-yield work	3.1	4.5	9.2	2.3	2.8	3.0	-0.4	2.7	-0.1	-1.2
Progressive ratio test 1 active lever presses	0.9	1.1	1.6	1.3	0.9	1.0	-0.7	0.9	-1.2	1.1
Progressive ratio test 1 breakpoint	1.0	1.2	1.9	1.4	0.9	1.0	-0.8	0.9	-1.4	1.2
Progressive ratio test 1 inactive lever presses	1.4	2.0	4.2	1.5	1.3	1.3	-1.0	1.1	-2.0	1.3
Progressive ratio test 2 active lever presses	1.9	2.2	4.0	2.0	1.5	1.6	-0.8	1.5	-1.5	1.1
Progressive ratio test 2 breakpoint	2.0	2.3	4.2	2.1	1.6	1.7	-0.7	1.6	-1.4	1.0
Progressive ratio test 2 inactive lever presses	1.8	2.9	5.4	2.3	1.5	1.6	-0.5	1.6	-2.0	1.7
Incentive Sensitization - Responses	1.5	2.1	3.7	1.9	1.7	1.9	-0.4	1.6	-1.4	0.4
Incentive Sensitization - Breakpoint	1.6	2.1	3.7	1.9	1.7	1.9	-0.3	1.6	-1.3	0.4
Sum of active levers in priming session hrs 5-6	1.1	1.0	2.1	-0.8	-1.1	-1.1	1.4	-0.8	0.8	-0.9
Progressive ratio	0.1	0.2	0.5	0.7	0.1	0.2	0.4	0.2	-0.5	0.4
Food seeking constrained by brief footshock	1.2	1.5	2.6	1.2	0.9	0.6	1.3	1.2	-1.4	1.6
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	0.3	0.6	0.3	0.2	0.7	-0.6	0.8
Retroperitoneal fat weight	0.2	0.7	1.8	0.8	0.6	0.1	-0.9	0.4	-1.3	1.2
Reaction time number correct	0.1	0.2	0.7	0.2	0.1	0.5	-0.3	0.1	0.4	-0.8
Reaction time mean minus median	0.0	0.1	0.1	0.1	0.3	0.1	-0.4	0.3	-0.2	-0.2
Reaction time mean minus median AUC	0.3	0.6	1.3	-1.1	-0.9	-1.0	-0.5	-1.0	0.3	-0.1
Reaction time num false alarms	1.2	1.7	3.3	1.5	1.6	1.8	-0.8	1.6	-1.0	0.2
Reaction time num false alarms AUC	1.1	1.8	2.7	1.4	1.4	1.6	-1.1	1.4	-1.3	0.7
Reaction time trials correct on left	0.1	0.2	0.7	0.2	0.1	0.5	-0.3	0.1	0.4	-0.8
Reaction time trials on left	0.1	0.2	0.6	0.2	0.1	0.5	-0.4	0.1	0.3	-0.8
Reaction time mean	0.5	0.8	1.3	-1.1	-1.1	-1.0	-0.7	-1.0	-0.3	0.5
Reaction time mean AUC	0.7	1.2	2.5	-1.4	-1.6	-1.3	-0.6	-1.3	-0.2	0.5
Median of all reaction times	0.7	1.0	1.7	-1.2	-1.3	-1.1	-0.8	-1.1	-0.4	0.7
Reaction time omissions	1.1	1.6	5.3	-0.3	-0.3	-0.1	-2.3	-0.5	-1.8	1.5
Reaction time false alarm rate	0.9	1.2	1.7	1.1	1.2	1.2	-0.8	1.1	-1.3	0.9
Reaction time premature initiation rate	0.5	0.7	1.4	1.2	1.0	0.8	-0.4	0.9	-0.9	0.3
Reaction time premature initiations	0.4	0.7	1.6	1.3	0.9	1.0	-0.4	0.9	-0.9	-0.0
Std. dev. reaction times	0.4	0.8	1.2	-1.1	-1.0	-1.0	-0.8	-1.0	-0.3	0.6
Reaction time trials completed	0.1	0.2	0.6	0.2	0.1	0.5	-0.4	0.1	0.3	-0.8
Reaction time trials AUC	0.1	0.1	0.5	0.3	0.1	0.5	-0.2	0.1	0.3	-0.7
Run reversals in cocaine runway, females	2.3	2.3	4.8	1.1	2.2	1.8	-0.5	1.4	1.0	-1.8
Run reversals in cocaine runway, males	1.0	1.0	1.8	0.7	1.4	1.3	-0.5	0.9	0.3	-1.4
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.2	0.2	-0.0	0.0	0.3	0.1	-0.3
Latency to leave start box in cocaine runway, F	0.7	0.8	2.4	-0.0	1.0	0.9	-0.2	0.9	0.9	-1.6
Latency to leave start box in cocaine runway, M	1.0	0.9	2.0	-0.4	-0.8	-1.3	0.4	-0.8	-1.1	1.4
Std. dev. time between licks in bursts	0.3	0.4	0.9	1.0	0.5	0.6	0.7	0.8	0.0	-0.4
Total sessions with >9 infusions	0.5	0.7	1.7	1.3	0.7	1.0	0.6	1.0	0.0	0.1
Short access day 1 total inactive lever presses	1.1	1.4	3.2	1.2	1.7	1.8	-1.1	1.1	-0.3	-0.5
Short access day 10 total inactive lever presses	0.4	1.0	1.7	1.2	0.7	1.2	-1.2	0.7	-1.3	0.5
Short access day 1 total infusions	0.2	0.3	0.6	0.7	0.2	0.3	-0.4	0.1	-0.7	0.8
Short access day 10 total infusions	0.9	1.2	2.6	1.6	1.0	0.9	-0.2	0.9	-1.2	1.2
Short access total infusions	0.5	0.7	1.5	1.2	0.6	0.8	-0.4	0.5	-1.0	0.8
Short access day 1 locomotion	1.0	1.3	2.7	1.5	1.3	1.6	-0.4	1.3	-0.5	0.1
Short access day 10 total locomotion	2.4	4.5	11.1	3.3	2.2	2.3	-0.3	2.4	-1.9	0.9
Short access total locomotion	3.2	3.9	8.6	2.9	2.3	2.4	-0.3	2.4	-1.2	0.2
One hour access (0.3 mA shock)	0.3	0.4	1.0	1.0	0.6	0.9	0.0	0.7	0.0	-0.3
Compulsive drug intake	0.5	0.5	1.4	-1.0	-0.2	-0.1	-0.6	-0.3	1.2	-1.0
One hour access (shock baseline)	1.2	1.9	5.3	2.3	1.4	1.4	0.4	1.5	-1.1	0.4
Social response proportion	2.0	2.2	3.8	1.6	1.9	1.9	0.8	2.0	0.2	-1.1
Social responses	0.4	0.5	0.9	0.9	0.7	1.0	0.3	0.7	-0.9	0.3
Social time	1.8	2.4	5.2	1.5	2.0	2.3	0.4	2.0	0.1	-1.1
Soleus weight	0.5	1.5	2.8	1.3	1.7	1.5	0.4	1.5	0.5	-1.2
Bone: stiffness	0.1	0.2	0.6	0.2	0.6	0.4	-0.2	0.4	-0.5	0.8
Tibialis anterior weight	0.8	2.7	5.0	2.0	1.8	1.4	2.2	2.1	-0.1	-0.6
Time to tail flick, vehicle, before self-admin	1.0	1.1	2.4	-1.4	-0.5	-0.7	-1.5	-1.2	0.8	-0.7
Time to tail flick, vehicle, after self-admin	0.3	0.4	1.1	0.6	0.6	0.4	-1.1	0.6	-0.8	0.1
Time to tail flick, test, before self-admin	0.5	0.5	1.7	-0.2	-0.3	-0.1	1.0	0.1	1.3	-0.6
Time to tail flick, test, after self-admin	0.3	0.4	1.0	0.8	0.4	0.2	-0.2	0.3	-1.0	0.8
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	2.8	1.4	0.6	0.9	-0.2	1.0	-1.7	1.0
Delta time to tail flick, test, before/after SA	1.3	1.3	5.1	1.2	0.5	0.3	-0.7	0.1	-2.3	1.3
Tibia length	0.1	0.3	0.7	0.1	0.6	0.3	-0.6	0.2	0.7	-0.9
Ambulatory time before self-admin	0.2	0.4	1.3	-0.1	0.3	0.3	-0.8	0.1	0.7	-1.2
Ambulatory time after self-admin	0.3	0.4	2.0	-0.3	-0.2	-0.2	0.2	0.1	0.8	-1.4
Bone: tissue strength	0.7	0.7	1.8	-1.3	-1.0	-0.8	0.5	-0.7	0.9	-0.3
Total heroin consumption	0.1	0.1	0.6	0.3	0.1	-0.1	-0.4	-0.1	-0.8	0.2
Bone: trabecular number	1.3	2.2	10.0	-0.1	-0.2	0.3	-3.2	-0.6	-1.6	1.6
Bone: trabecular spacing	1.0	1.4	7.0	0.5	0.7	0.3	2.7	1.0	0.4	-0.7
Bone: trabecular thickness	1.7	2.2	9.4	1.1	1.0	1.4	-3.1	0.5	-1.0	0.6
Bone: trabecular tissue density	0.6	0.9	1.9	-1.1	-1.0	-0.9	-1.4	-1.2	0.2	0.3
Water consumed over 24 hours	0.1	0.1	0.2	0.3	0.4	0.2	-0.4	0.0	0.3	-0.3
Number of responses in last shaping day	1.9	2.1	3.6	1.7	1.6	1.9	-1.5	1.5	-0.6	-0.4