LOC134480867

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	LOC134480867	0.1	0.07	3.1e-06	0.06	0.06	0.05	0.05	2.1e-05	1.3e-05	6.8e-05	9.1e-05
2	NAcc	gene expression	LOC134480867	0.05	0.03	2.5e-07	0.05	0.04	0.04	0.04	1.6e-07	2.2e-07	2.2e-06	5.2e-07
3	Adipose	gene expression	LOC134480867	0.06	0.04	9.4e-07	0.04	0.06	0.05	0.05	1.6e-05	9.9e-07	4.0e-06	2.8e-06
4	PL	gene expression	LOC134480867	0.04	0.03	5.0e-04	0.02	0.03	0.02	0.02	4.8e-03	7.7e-04	3.1e-03	6.7e-03
5	Brain	gene expression	LOC134480867	0.04	0.02	5.7e-03	0.02	0.02	-0	0.02	5.8e-03	2.3e-03	4.0e-01	9.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.3	4.3	5.0	1.8	-2.1	2.1	2.2	2.1
Area under the delay curve	0.2	0.3	0.8	0.4	-0.6	0.9	0.4	0.3
BMI with tail	1.9	6.5	10.4	-3.2	2.9	-2.5	-2.2	-1.6
BMI without tail	0.5	2.6	4.9	-2.2	1.7	-1.6	-1.3	-0.9
Body weight	5.0	21.9	34.1	-5.8	5.3	-4.4	-4.1	-3.3
Weight adjusted by age	0.1	0.2	0.5	-0.7	0.4	0.4	0.2	0.4
Bone surface	0.2	0.4	1.0	-0.0	-0.3	0.4	0.9	1.0
Bone volume	0.5	1.0	2.2	0.3	-0.7	0.7	1.3	1.5
Breakpoint value in progressive ratio session	0.0	0.0	0.0	-0.1	-0.1	0.2	0.1	0.1
Number of licking bursts	0.2	0.5	1.4	0.4	-0.4	0.3	1.0	1.2
Context. condit. distance diff. score	2.2	2.7	4.8	-1.3	1.3	-1.1	-2.0	-2.2
Locomotion velocity, session 1	0.3	0.3	0.8	-0.9	0.7	-0.5	-0.3	-0.2
Locomotion distance, session 1	1.4	1.9	3.7	-1.9	1.6	-1.3	-0.9	-0.6
Locomotion velocity, session 2	0.1	0.1	0.2	-0.5	0.5	-0.3	-0.3	-0.3
Locomotion distance, session 2	0.1	0.2	0.4	-0.5	0.3	-0.0	0.4	0.7
Locomotion velocity, session 3	0.0	0.0	0.0	0.1	-0.0	0.2	0.1	-0.1
Locomotion distance, session 3	0.2	0.2	0.4	-0.5	0.6	-0.5	-0.3	-0.2
Stereotopy head waving bouts, day 3	1.8	2.2	3.2	1.5	-1.8	1.8	1.2	0.9
Stereotopy head waving duration, day 3	0.1	0.2	0.4	0.1	-0.5	0.7	0.2	0.0
Locomotion velocity, session 7	0.7	0.8	1.4	-1.0	1.2	-1.0	-0.4	-0.2
Locomotion distance, session 7	0.3	0.4	1.2	-0.4	0.8	-1.1	-0.4	-0.2
Stereotopy head waving bouts, day 7	0.7	0.8	1.5	0.5	-0.8	1.2	0.9	0.8
Stereotopy head waving duration, day 7	0.3	0.4	1.2	0.1	-0.5	1.1	0.5	0.4
Locomotion velocity, session 8	7.8	9.4	10.1	-3.1	3.1	-2.9	-3.2	-3.0
Locomotion distance, session 8	1.2	1.7	2.7	-1.7	1.4	-1.1	-1.2	-1.1
Degree of sensitization distance	1.0	1.0	1.9	-0.7	0.9	-1.4	-1.0	-0.9
Degree of sensitization stereotypy	0.7	0.8	1.4	0.5	-0.9	1.2	0.9	0.9
Conditioned locomotion	0.2	0.2	0.4	0.4	-0.3	0.6	0.4	0.2
Cocaine response after cond. corrected	0.7	1.0	1.6	0.2	-0.7	1.3	1.1	1.3
Cocaine response after cond. not corrected	0.8	1.2	2.0	0.3	-0.8	1.4	1.2	1.4
Cocaine response before conditioning	0.0	0.0	0.1	0.3	-0.1	0.0	0.1	0.1
Saline control response	0.4	0.6	1.3	-1.1	0.9	-0.5	-0.6	-0.5
Bone: connectivity density	3.4	5.4	6.3	2.2	-2.3	2.3	2.5	2.3
Bone: cortical apparent density	3.5	5.5	9.7	3.1	-2.8	2.2	1.9	1.4
Bone: cortical area	0.1	0.2	0.3	0.3	-0.3	0.4	0.5	0.5
Bone: cortical porosity	0.6	0.6	1.0	0.2	-0.6	1.0	0.9	1.0
Bone: cortical porosity	0.3	0.3	0.5	-0.3	-0.2	0.7	0.6	0.7
Bone: cortical thickness	0.7	1.2	2.0	1.2	-1.1	1.4	0.9	0.7
Bone: cortical thickness	4.1	5.0	8.2	2.1	-2.4	2.9	2.0	1.6
Bone: cortical tissue density	3.5	5.6	9.8	3.1	-2.8	2.2	1.9	1.4
Condit. Reinf. active minus inactive responses	0.8	0.9	1.5	1.2	-1.0	1.1	0.7	0.5
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.0	1.4	-1.0	1.1	0.8	0.4
Condit. Reinf. active responses	0.7	0.9	1.5	1.2	-1.0	1.0	0.7	0.6
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.2	-0.3	0.3	0.3	0.4
Incentive salience index mean	1.8	2.3	3.4	1.8	-1.6	1.4	1.4	1.3
Condit. Reinf. lever presses	1.4	2.2	2.6	1.6	-1.4	1.1	1.6	1.5
Condit. Reinf. active minus inactive responses	1.2	1.8	2.2	1.4	-1.4	1.0	1.4	1.5
Condit. Reinf. active-inactive response ratio	1.0	1.6	2.2	1.2	-1.3	0.9	1.4	1.5
Condit. Reinf. active responses	2.1	3.0	3.8	1.6	-1.7	1.4	1.9	2.0
Condit. Reinf. inactive responses	1.5	2.2	2.7	1.3	-1.4	1.4	1.6	1.6
Condit. Reinf. lever presses	0.1	0.1	0.2	0.3	-0.2	0.4	0.3	0.3
Condit. Reinf. lever reinforcers received	2.2	3.1	3.5	1.7	-1.7	1.5	1.9	1.9
Conditioned reinforcement - actives	0.0	0.1	0.3	0.5	-0.3	-0.1	0.2	0.2
Conditioned reinforcement - inactives	0.1	0.2	0.6	0.8	-0.6	-0.1	0.1	0.1
Conditioned locomotion	0.6	0.9	1.3	1.1	-0.8	0.4	1.1	1.2
Patch foraging indifference point 0 sec	0.9	2.4	4.6	2.2	-1.4	1.0	1.6	1.3
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.4	0.2	0.2	0.1	0.0
Delay disc. indifference point, 0s delay	1.8	2.0	2.2	1.4	-1.5	1.4	1.4	1.3
Delay disc. indifference point, 16s delay	0.2	0.3	0.8	0.1	-0.4	0.9	-0.3	-0.7
Delay disc. indifference point, 2s delay	1.3	1.4	2.0	1.0	-1.1	1.1	1.3	1.4
Delay disc. indifference point, 24s delay	0.1	0.2	0.4	-0.3	0.4	-0.4	-0.6	-0.6
Delay disc. indifference point, 4s delay	1.1	1.1	2.4	0.7	-1.0	1.6	0.9	0.9
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	0.3	-0.2	0.2	0.4	0.4
Indifference point function ln k	0.0	0.1	0.4	-0.0	0.1	-0.1	-0.4	-0.6
Indifference point function log k	0.0	0.1	0.4	-0.0	0.1	-0.1	-0.4	-0.6
Patch foraging total patch changes 0 sec	0.5	1.6	3.3	1.8	-1.1	0.6	1.3	1.1
Patch foraging total patch changes 12 sec	5.2	7.0	8.9	2.7	-2.4	2.2	3.0	2.8
Patch foraging total patch changes 18 sec	0.2	0.5	0.8	0.9	-0.3	0.2	0.9	0.8
Patch foraging total patch changes 24 sec	0.4	1.3	1.8	1.0	-0.8	1.2	1.3	1.2
Patch foraging total patch changes 6 sec	1.3	2.2	3.1	1.8	-1.4	1.2	1.6	1.4
Patch foraging time to switch 0 sec	0.0	0.2	0.3	0.3	-0.3	0.4	0.5	0.5
Patch foraging water rate 0 sec	0.0	0.1	0.3	0.5	-0.3	0.2	0.2	0.2
Patch foraging water rate 12 sec	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.1	-0.2
Patch foraging water rate 18 sec	0.5	1.2	1.7	0.7	-0.9	1.2	1.3	1.3
Patch foraging water rate 24 sec	0.6	0.9	1.4	1.0	-1.2	0.7	1.0	0.8
Patch foraging water rate 6 sec	1.8	2.6	2.9	1.6	-1.6	1.7	1.6	1.5
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	1.0	0.3	-0.2	-0.1	-0.8	-1.0
Distance traveled before self-admin	0.1	0.2	0.5	0.1	-0.3	0.7	0.4	0.5
Distance traveled after self-admin	0.3	0.4	0.8	-0.9	0.6	-0.4	-0.7	-0.6
Extensor digitorum longus weight	9.2	36.5	40.7	-5.9	6.4	-6.2	-6.0	-5.6
Bone: elastic displacement	0.1	0.1	0.3	0.2	-0.0	-0.5	-0.1	-0.1
Bone: elastic work	0.1	0.2	0.3	0.1	-0.4	0.6	0.4	0.5
Bone: endosteal estimation	1.2	2.9	5.2	-2.3	2.0	-1.9	-1.1	-0.8
Bone: endosteal perimeter	0.7	1.8	3.2	-1.5	1.4	-1.8	-1.0	-0.8
Epididymis fat weight	0.1	0.3	0.8	-0.9	0.6	-0.2	-0.2	0.0
Delta time in closed arm before/after self-admin	4.2	4.0	5.6	-2.4	1.9	-1.7	-2.0	-1.9
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.2	-0.1	0.1	-0.5	-0.5
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	0.1	-0.3	0.4	0.3	0.4
Delay discount exponential model param	0.1	0.1	0.5	-0.2	0.4	-0.7	-0.2	-0.1
Extinction: sum of active levers before priming	1.0	1.5	2.5	-1.6	1.4	-1.1	-1.1	-0.9
Active lever presses in extinction session 6	1.4	1.5	2.6	-0.2	-0.4	1.6	1.4	1.6
Bone: final force	0.8	1.4	2.4	0.5	-0.9	1.2	1.5	1.5
Bone: final moment	0.6	1.0	1.8	0.3	-0.7	1.0	1.3	1.4
Food consumed during 24 hour testing period	0.4	0.8	1.0	-1.0	0.8	-0.9	-0.9	-0.7
Glucose	0.1	0.1	0.2	-0.4	0.0	0.2	0.3	0.5
Heart weight	2.7	4.4	5.1	-2.2	2.0	-2.3	-2.1	-1.9
Delay discount hyperbolic model param	0.1	0.1	0.5	-0.2	0.4	-0.7	-0.2	-0.1
Intermittent access intake day 1-15 change	0.0	0.2	0.4	0.2	-0.6	0.7	0.1	0.1
Intermittent access intake escalation	0.0	0.1	0.4	0.1	-0.6	0.6	-0.0	-0.0
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.4	0.1	-0.3	-0.4	-0.3
Intermitt. access day 1 inactive lever presses	0.2	2.1	4.2	1.2	-1.6	2.1	1.2	1.0
Intermitt. access day 15 inactive lever presses	0.3	1.7	3.1	1.8	-1.5	1.2	1.0	0.8
Intermitt. access escalation Index	0.7	2.1	4.3	-2.1	1.6	-0.7	-1.3	-1.2
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	-0.1	0.0	-0.1	-0.2
Intermittent access day 15 total infusions	0.1	0.2	0.3	-0.1	-0.3	0.5	-0.4	-0.5
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.4	0.3	-0.6	0.6	-0.0	-0.2
Intermittent access total infusions	0.1	0.1	0.2	-0.0	-0.2	0.3	-0.4	-0.5
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.3	-0.1	-0.2	0.1	0.0
Intermittent access day 15 total locomotion	0.1	0.4	0.5	0.7	-0.6	0.2	0.7	0.7
Intermittent access total locomotion	0.6	0.7	1.2	1.1	-1.0	0.7	0.7	0.6
Intermittent access standard deviation	0.4	1.8	3.1	1.6	-1.8	1.4	1.0	0.8
Left kidney weight	0.2	1.5	2.9	-1.7	1.3	-0.5	-1.1	-1.2
Right kidney weight	0.0	0.2	0.4	-0.6	0.1	0.6	0.5	0.5
Cocaine induced anxiety	1.2	3.2	5.4	-2.3	2.0	-1.2	-1.7	-1.5
Post-drug Anxiety	0.9	1.0	1.3	-1.1	1.0	-0.6	-1.1	-1.0
Baseline Anxiety	0.9	1.5	2.9	1.7	-1.3	0.8	1.1	1.0
Tail length	0.3	1.5	1.9	-1.4	1.3	-0.9	-1.2	-1.2
Length with tail	1.7	7.5	11.1	-3.3	3.2	-2.4	-2.5	-2.2
Length without tail	1.3	6.9	9.5	-3.1	3.1	-2.7	-2.2	-1.8
Times rat made contact with spout	0.8	1.0	1.3	1.1	-1.1	0.5	1.0	1.1
Lifetime Intake	0.1	0.2	0.3	0.2	-0.5	0.6	-0.2	-0.3
Liver weight, left	0.1	0.2	0.5	-0.7	0.6	-0.6	-0.1	0.0
Liver weight, right	0.3	0.5	1.9	-0.0	-0.6	1.4	0.5	0.2
Locomotor activity	0.9	1.4	2.6	0.7	-0.8	1.1	1.5	1.6
Locomotor testing distance	1.4	3.4	4.0	1.8	-1.6	1.9	2.0	1.9
Locomotor testing rearing	2.1	7.6	9.4	3.1	-2.7	2.9	2.8	2.3
Locomotion in novel chamber	4.0	5.4	6.5	2.3	-2.5	2.5	2.2	2.0
Locomotion in novel chamber post-restriction	0.3	0.8	1.5	0.7	-0.9	0.7	0.9	1.2
Fecal boli incidents, locomotor time 1	0.1	0.3	0.9	-0.3	0.4	-0.9	-0.5	-0.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.0	-0.2	0.5	0.4	0.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.5	-0.2	0.1	0.1	-0.1
Bouts of movement, locomotor time 1	0.4	0.5	1.1	-0.8	1.1	-0.4	-0.4	-0.3
Total resting periods, locomotor time 1	0.8	0.9	2.0	-1.1	1.4	-0.9	-0.7	-0.5
Rest time, locomotor task time 1	0.1	0.1	0.3	0.2	-0.1	-0.3	0.5	0.6
Distance moved, locomotor task time 1	0.1	0.2	0.3	-0.3	-0.2	0.5	-0.4	-0.5
Vertical activity count, locomotor time 1	0.0	0.3	0.4	-0.6	0.4	-0.3	-0.6	-0.5
Time >=10cm from walls, locomotor time 2	0.5	1.3	2.0	1.1	-0.9	1.0	1.4	1.3
Bouts of movement, locomotor time 2	0.1	0.4	0.7	0.7	-0.2	0.7	0.9	0.6
Total resting periods, locomotor time 2	0.0	0.2	0.3	0.5	-0.0	0.5	0.6	0.3
Rest time, locomotor task time 2	0.4	0.6	0.8	-0.8	0.9	-0.9	-0.6	-0.5
Distance moved, locomotor task time 2	0.2	0.2	0.7	-0.8	0.2	0.0	-0.4	-0.4
Vertical activity count, locomotor time 2	0.2	0.6	0.8	-0.8	0.6	-0.6	-0.9	-0.8
Light reinforcement 1	1.1	4.8	5.4	2.2	-2.1	2.2	2.3	2.2
Light reinforcement 2	0.4	0.9	1.4	0.4	-0.8	1.1	1.1	1.2
Bone: marrow area	1.1	2.8	4.9	-2.2	1.9	-1.9	-1.1	-0.8
Bone: maximum diameter	0.1	0.2	0.4	0.2	-0.2	0.3	0.6	0.6
Bone: maximum force	0.1	0.1	0.3	-0.5	0.2	0.1	0.4	0.5
Bone: maximum moment	0.1	0.1	0.5	-0.7	0.4	-0.1	0.2	0.2
Mean time between licks in bursts	0.3	1.7	3.8	-1.1	1.4	-2.0	-1.0	-0.8
Mean num. licks in bursts	0.0	0.1	0.2	0.3	-0.4	0.2	-0.3	-0.4
Cd content in liver	1.5	1.6	2.2	-1.2	0.9	-1.5	-1.5	-1.3
Co content in liver	2.3	2.7	3.7	-1.2	1.3	-1.7	-1.9	-1.9
Cu content in liver	0.1	0.1	0.2	0.2	-0.1	0.3	-0.3	-0.5
Fe content in liver	1.3	1.6	2.9	-1.7	1.4	-1.1	-1.1	-0.8
K content in liver	1.0	1.0	2.9	0.6	-0.8	1.7	0.9	0.6
Mg content in liver	0.4	0.5	1.6	0.7	-0.6	1.2	0.2	-0.2
Mn content in liver	0.9	1.1	1.9	1.4	-0.9	1.1	1.0	0.6
Na content in liver	0.7	0.8	1.6	-0.1	-0.5	1.3	1.0	1.2
Rb content in liver	1.1	1.3	2.1	1.5	-1.3	0.9	1.0	0.8
Se content in liver	6.7	7.9	10.7	2.9	-3.0	3.3	2.6	2.1
Sr content in liver	0.2	0.2	0.6	0.1	0.2	-0.4	-0.5	-0.8
Zn content in liver	2.8	3.3	5.0	1.9	-2.1	2.2	1.5	1.2
Bone: minimum diameter	0.3	0.6	1.4	-1.2	0.9	-0.7	-0.5	-0.4
Time in familiar zone, hab. session 1	0.5	0.6	1.1	-0.1	-0.6	0.8	0.8	1.0
Time in novel zone, hab. session 1	0.3	0.3	1.2	1.1	-0.6	0.1	-0.1	-0.4
Total zone transitions, hab. session 1	1.8	2.5	3.0	-1.6	1.4	-1.4	-1.7	-1.7
Total locomotion distance, hab. session 1	0.1	0.1	0.3	-0.1	-0.1	0.1	-0.5	-0.5
Locomotion velocity, hab. session 1	0.3	0.4	0.6	-0.6	0.4	-0.2	-0.8	-0.8
Time in familiar zone, hab. session 2	0.6	0.7	1.5	0.3	-0.9	1.2	0.7	0.7
Time in novel zone, hab. session 2	0.2	0.2	0.6	0.8	-0.3	-0.1	0.3	0.2
Total zone transitions, hab. session 2	0.9	1.2	1.6	-1.2	1.1	-1.3	-1.0	-0.8
Total locomotion distance, hab. session 2	0.2	0.2	0.4	-0.6	0.3	-0.6	-0.5	-0.2
Locomotion velocity, hab. session 2	0.3	0.5	0.6	-0.8	0.6	-0.8	-0.7	-0.4
Novel to familiar place preference ratio	0.9	1.2	1.7	-1.1	1.2	-0.6	-1.1	-1.3
Novelty place preference	0.9	1.1	1.8	-1.0	1.1	-0.6	-1.2	-1.4
Time in novel zone, NPP test	0.4	0.5	1.0	-0.6	0.7	-0.2	-0.8	-1.0
Total zone transitions, NPP test	0.3	0.5	1.0	-0.8	0.7	-1.0	-0.3	0.0
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.2	-0.1	-0.3	0.2	0.4
Locomotion velocity, NPP test	0.2	0.3	0.8	-0.6	0.5	-0.9	-0.4	-0.2
Intraocular pressure	3.2	5.2	7.1	-1.9	2.1	-2.7	-2.4	-2.2
Delta distance traveled before/after self-admin	1.6	1.8	2.2	-1.3	1.2	-1.2	-1.5	-1.5
Delta ambulatory time before/after self-admin	1.0	1.8	2.5	-1.6	1.4	-1.2	-1.3	-1.2
Parametrial fat weight	0.7	1.7	2.7	0.8	-1.1	1.3	1.5	1.6
Pavlov. Cond. lever latency	2.8	3.5	5.0	-1.5	1.7	-1.6	-2.1	-2.2
Pavlov. Cond. magazine entry latency	10.1	13.0	14.1	3.4	-3.7	3.6	3.7	3.6
Pavlov. Cond. change in total contacts	8.0	8.7	11.0	3.2	-3.3	3.1	2.7	2.3
Pavlov. Cond. index score	8.7	11.1	12.1	3.2	-3.4	3.1	3.5	3.4
Pavlov. Cond. latency score	6.8	8.7	9.9	2.7	-3.0	2.7	3.1	3.2
Pavlov. Cond. lever contacts	3.7	4.4	6.2	1.8	-2.0	1.7	2.4	2.5
Pavlov. Cond. magazine entry number	11.8	14.9	17.6	-3.9	4.2	-3.8	-3.8	-3.6
Pavlov. Cond. intertrial magazine entries	1.6	1.9	2.2	-1.1	1.5	-1.3	-1.5	-1.5
Pavlov. Cond. lever-magazine prob. diff.	10.3	12.8	13.8	3.5	-3.7	3.3	3.7	3.6
Pavlov. Cond. response bias	10.1	12.6	13.7	3.5	-3.7	3.5	3.6	3.4
Pavlov. Cond. lever latency	0.6	0.8	1.1	-0.8	0.8	-0.8	-1.0	-1.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.2	-0.0
Pavlov. Cond. change in total contacts	0.4	0.9	1.7	1.3	-1.0	0.5	0.9	0.8
Pavlov. Cond. index score	0.2	0.3	0.4	0.5	-0.5	0.3	0.5	0.7
Pavlov. Cond. latency score	0.1	0.2	0.3	0.4	-0.3	0.1	0.4	0.6
Pavlov. Cond. lever contacts	0.6	0.9	1.3	0.8	-0.8	0.8	1.0	1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.2	0.2	-0.3	-0.3	-0.3
Pavlov. Cond. intertrial magazine entries	1.0	2.2	3.2	-1.1	1.5	-1.5	-1.6	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.3	-0.3	0.1	0.4	0.5
Pavlov. Cond. response bias	1.1	1.5	2.0	1.1	-1.2	1.2	1.3	1.4
Time in closed arm before self-admin	0.9	1.5	2.7	1.6	-1.2	1.2	1.2	0.8
Time in closed arm after self-admin	0.3	0.3	1.0	-0.3	0.3	-0.3	-0.6	-1.0
Time in open arm before self-admin	0.8	0.9	1.8	-1.3	1.2	-0.8	-0.8	-0.6
Time in open arm after self-admin	0.2	0.2	0.3	-0.5	0.3	-0.4	-0.6	-0.4
Bone: periosteal estimation	0.1	0.3	0.8	-0.9	0.6	-0.5	-0.0	0.2
Bone: periosteal perimeter	0.3	0.6	1.2	-1.1	0.9	-1.0	-0.4	-0.1
Bone: post-yield work	0.8	1.4	1.8	-1.3	1.3	-1.3	-1.0	-1.0
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.0	0.0	0.4	0.0	-0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.1	0.1	0.2	-0.1	-0.2
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.5	0.4	-0.5	0.7	0.2	0.1
Progressive ratio test 2 active lever presses	0.7	0.9	1.4	1.2	-1.1	0.8	0.9	0.8
Progressive ratio test 2 breakpoint	0.8	1.0	1.5	1.2	-1.1	0.9	0.9	0.9
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	0.6	-0.6	0.3	0.2	0.2
Incentive Sensitization - Responses	0.8	2.3	3.7	1.9	-1.6	0.8	1.5	1.5
Incentive Sensitization - Breakpoint	0.9	2.1	3.3	1.8	-1.5	0.8	1.4	1.4
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.6	-0.3	-0.2	0.8	0.3	0.3
Progressive ratio	0.1	0.2	0.4	0.1	-0.0	0.6	0.6	0.7
Food seeking constrained by brief footshock	0.6	0.7	1.0	0.5	-0.6	0.9	1.0	1.0
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	-0.1	-0.0	-0.2	-0.3	-0.3
Retroperitoneal fat weight	0.1	0.3	0.4	0.4	-0.5	0.4	0.6	0.6
Reaction time number correct	0.2	0.6	0.9	-0.9	0.8	-1.0	-0.7	-0.5
Reaction time mean minus median	0.1	0.6	1.3	-0.4	0.6	-1.2	-0.8	-0.7
Reaction time mean minus median AUC	0.0	0.1	0.3	0.1	0.1	-0.6	-0.3	-0.2
Reaction time num false alarms	0.6	1.1	2.0	0.8	-0.7	0.7	1.3	1.4
Reaction time num false alarms AUC	0.5	1.1	2.2	0.8	-0.6	0.4	1.4	1.5
Reaction time trials correct on left	0.2	0.6	0.9	-0.9	0.8	-1.0	-0.7	-0.5
Reaction time trials on left	0.2	0.6	0.9	-0.9	0.8	-0.9	-0.6	-0.5
Reaction time mean	0.1	0.2	0.5	0.7	-0.6	0.5	0.0	-0.1
Reaction time mean AUC	0.1	0.2	0.4	0.6	-0.6	0.6	-0.0	-0.2
Median of all reaction times	0.7	1.0	1.6	1.3	-1.2	1.3	0.6	0.4
Reaction time omissions	0.3	0.5	0.8	0.9	-0.9	0.7	0.6	0.6
Reaction time false alarm rate	1.2	1.6	2.5	1.2	-0.9	0.9	1.5	1.6
Reaction time premature initiation rate	0.5	0.7	2.4	0.2	-0.8	1.6	0.5	0.5
Reaction time premature initiations	0.0	0.2	0.4	-0.6	-0.0	0.6	-0.2	-0.1
Std. dev. reaction times	0.0	0.0	0.1	0.2	-0.1	-0.3	-0.2	-0.2
Reaction time trials completed	0.2	0.6	0.9	-0.9	0.8	-0.9	-0.6	-0.5
Reaction time trials AUC	0.2	0.6	1.0	-0.8	0.8	-1.0	-0.7	-0.5
Run reversals in cocaine runway, females	2.3	2.5	4.6	-1.6	1.1	-0.8	-2.0	-2.1
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.3	-0.5	0.4	0.1	0.1
Latency to leave start box in cocaine runway	1.0	1.4	1.6	-1.0	1.0	-1.3	-1.3	-1.3
Latency to leave start box in cocaine runway, F	1.7	2.1	2.7	-1.5	1.3	-1.2	-1.6	-1.5
Latency to leave start box in cocaine runway, M	0.1	0.1	0.4	0.7	-0.4	-0.0	0.3	0.1
Std. dev. time between licks in bursts	0.0	0.1	0.2	-0.1	0.1	-0.4	0.3	0.4
Total sessions with >9 infusions	0.1	0.2	0.3	0.3	-0.5	0.5	-0.3	-0.5
Short access day 1 total inactive lever presses	0.9	1.7	2.9	1.5	-1.7	1.4	1.0	0.8
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.4	-0.2	-0.1	-0.1	0.0
Short access day 1 total infusions	0.2	0.4	1.2	0.2	-0.7	1.1	-0.1	-0.5
Short access day 10 total infusions	0.2	0.3	0.5	0.5	-0.7	0.7	0.4	0.2
Short access total infusions	0.2	0.3	1.0	0.3	-0.8	1.0	0.1	-0.1
Short access day 1 locomotion	0.6	1.0	1.7	0.9	-1.2	1.3	0.8	0.5
Short access day 10 total locomotion	0.5	2.1	2.9	1.7	-1.5	0.9	1.5	1.5
Short access total locomotion	0.2	0.3	0.5	0.7	-0.7	0.3	0.5	0.3
One hour access (0.3 mA shock)	0.3	0.3	0.5	-0.5	0.6	-0.5	-0.7	-0.7
Compulsive drug intake	0.6	0.9	2.2	-0.3	0.5	-0.8	-1.3	-1.5
One hour access (shock baseline)	0.0	0.0	0.2	-0.2	-0.0	0.4	0.1	0.1
Social response proportion	0.4	0.4	0.9	-0.9	0.7	-0.4	-0.6	-0.6
Social responses	0.1	0.2	0.3	-0.2	-0.2	0.3	0.5	0.6
Social time	0.1	0.1	0.5	-0.3	-0.0	-0.2	0.3	0.7
Soleus weight	0.1	0.4	1.0	-0.5	0.3	-0.1	0.7	1.0
Bone: stiffness	0.1	0.2	0.3	-0.5	0.1	0.6	0.3	0.3
Tibialis anterior weight	1.4	4.8	7.4	-2.7	2.4	-1.9	-2.0	-1.8
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.5	-0.2	-0.6	0.3	0.5
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.7	0.3	0.0	0.1	0.6	0.9
Time to tail flick, test, before self-admin	0.8	1.0	1.4	-1.2	1.2	-0.9	-0.9	-0.7
Time to tail flick, test, after self-admin	0.3	0.3	0.7	0.4	-0.3	-0.3	0.6	0.8
Delta time to tail flick, vehicle, before/after SA	0.8	0.9	1.9	0.4	-0.4	0.8	1.2	1.4
Delta time to tail flick, test, before/after SA	2.0	2.5	3.4	1.9	-1.7	1.1	1.6	1.5
Tibia length	1.4	3.8	7.4	-2.7	2.1	-1.6	-1.7	-1.3
Ambulatory time before self-admin	0.0	0.0	0.1	0.1	-0.3	0.3	0.1	0.1
Ambulatory time after self-admin	0.9	1.5	2.7	-1.6	1.2	-0.9	-1.2	-1.0
Bone: tissue strength	1.3	1.4	2.6	-0.9	1.3	-1.6	-1.0	-1.0
Total heroin consumption	4.2	4.9	6.9	1.8	-2.1	2.0	2.5	2.6
Bone: trabecular number	5.2	9.7	11.2	2.7	-3.1	3.2	3.3	3.3
Bone: trabecular spacing	1.4	2.1	3.3	-1.8	1.5	-1.4	-1.4	-1.0
Bone: trabecular thickness	0.2	0.2	0.3	0.5	-0.5	0.1	0.6	0.6
Bone: trabecular tissue density	0.2	0.4	1.2	0.1	0.4	-0.4	-0.7	-1.1
Water consumed over 24 hours	0.1	0.1	0.4	-0.2	0.2	-0.6	-0.1	0.1
Number of responses in last shaping day	0.2	0.2	0.4	0.7	-0.6	0.1	-0.2	-0.4