Hub : Genes

LOC134480862

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression LOC134480862 0.08 0.06 3.8e-03 0.03 0.02 0.03 0.03 3.1e-04 1.5e-03 4.1e-04 2.5e-04
2 Adipose gene expression LOC134480862 0.09 0.05 1.7e-12 0.1 0.11 0.11 0.1 2.7e-11 6.0e-12 7.7e-12 1.2e-11
3 Brain gene expression LOC134480862 0.05 0.04 5.4e-04 0.04 0.03 0.03 0.03 1.6e-04 5.1e-04 6.6e-04 6.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.42.54.21.3-2.01.3
Area under the delay curve1.01.11.9-1.40.2-1.2
BMI with tail4.214.317.13.9-3.34.1
BMI without tail0.10.30.4-0.60.6-0.3
Body weight1.98.49.9-3.13.0-2.5
Weight adjusted by age0.50.70.9-0.80.9-0.7
Bone surface0.10.20.30.3-0.50.5
Bone volume0.50.91.30.7-1.11.0
Breakpoint value in progressive ratio session3.54.24.8-2.02.2-2.0
Number of licking bursts0.10.10.10.3-0.30.3
Context. condit. distance diff. score0.10.10.30.3-0.10.5
Locomotion velocity, session 10.00.00.10.10.20.2
Locomotion distance, session 15.36.77.7-2.62.8-2.4
Locomotion velocity, session 22.22.52.8-1.71.5-1.5
Locomotion distance, session 25.37.48.1-2.82.6-2.7
Locomotion velocity, session 30.40.50.7-0.80.6-0.7
Locomotion distance, session 34.65.16.0-2.52.1-2.2
Stereotopy head waving bouts, day 34.35.07.32.0-2.72.0
Stereotopy head waving duration, day 32.42.83.51.6-1.91.6
Locomotion velocity, session 71.21.31.8-1.11.3-0.9
Locomotion distance, session 73.64.65.3-2.32.0-2.1
Stereotopy head waving bouts, day 71.01.11.31.0-1.21.0
Stereotopy head waving duration, day 70.60.70.80.9-0.80.9
Locomotion velocity, session 80.81.02.1-0.71.4-0.6
Locomotion distance, session 82.13.03.5-1.81.9-1.5
Degree of sensitization distance0.00.00.00.10.20.0
Degree of sensitization stereotypy0.50.50.60.7-0.80.7
Conditioned locomotion0.20.30.70.3-0.80.2
Cocaine response after cond. corrected2.53.05.01.3-2.21.6
Cocaine response after cond. not corrected1.21.43.30.4-1.80.8
Cocaine response before conditioning1.41.62.4-1.60.9-1.3
Saline control response0.30.40.5-0.70.5-0.5
Bone: connectivity density0.91.32.41.0-1.60.8
Bone: cortical apparent density0.10.20.2-0.40.3-0.5
Bone: cortical area0.10.10.2-0.4-0.2-0.4
Bone: cortical porosity0.80.81.20.8-1.10.7
Bone: cortical porosity0.60.61.20.7-1.10.5
Bone: cortical thickness0.50.81.2-1.10.1-1.0
Bone: cortical thickness0.70.81.4-1.2-0.3-1.0
Bone: cortical tissue density0.20.30.3-0.50.4-0.6
Condit. Reinf. active minus inactive responses0.10.10.10.3-0.30.3
Condit. Reinf. active-inactive response ratio0.90.91.11.0-1.00.9
Condit. Reinf. active responses0.40.50.60.8-0.60.7
Condit. Reinf. inactive responses0.10.10.10.4-0.30.3
Incentive salience index mean0.20.20.20.4-0.50.4
Condit. Reinf. lever presses0.10.10.20.4-0.30.4
Condit. Reinf. active minus inactive responses0.10.10.2-0.1-0.50.4
Condit. Reinf. active-inactive response ratio0.80.91.60.8-0.81.3
Condit. Reinf. active responses0.10.10.2-0.1-0.50.3
Condit. Reinf. inactive responses0.10.10.2-0.1-0.4-0.2
Condit. Reinf. lever presses0.20.30.3-0.60.6-0.4
Condit. Reinf. lever reinforcers received0.00.10.1-0.3-0.30.0
Conditioned reinforcement - actives0.40.71.40.5-1.20.8
Conditioned reinforcement - inactives0.00.00.0-0.10.10.0
Conditioned locomotion3.03.95.61.6-2.41.9
Patch foraging indifference point 0 sec0.61.12.30.7-1.50.7
Patch foraging indifference point AUC0.00.10.10.20.40.2
Delay disc. indifference point, 0s delay0.50.51.1-0.70.1-1.0
Delay disc. indifference point, 16s delay0.20.20.3-0.6-0.5-0.2
Delay disc. indifference point, 2s delay0.80.91.4-1.1-0.2-1.2
Delay disc. indifference point, 24s delay0.70.81.2-1.00.5-1.1
Delay disc. indifference point, 4s delay5.86.18.3-2.91.6-2.7
Delay disc. indifference point, 8s delay0.10.20.2-0.5-0.4-0.4
Indifference point function ln k0.20.30.7-0.4-0.1-0.8
Indifference point function log k0.20.30.7-0.4-0.1-0.8
Patch foraging total patch changes 0 sec0.30.61.50.4-1.20.4
Patch foraging total patch changes 12 sec1.41.92.81.1-1.71.3
Patch foraging total patch changes 18 sec1.21.92.21.4-1.21.5
Patch foraging total patch changes 24 sec0.81.41.91.1-1.41.1
Patch foraging total patch changes 6 sec0.91.41.81.0-1.31.3
Patch foraging time to switch 0 sec0.30.61.00.7-0.61.0
Patch foraging water rate 0 sec0.10.10.1-0.2-0.4-0.4
Patch foraging water rate 12 sec1.02.12.7-1.61.2-1.5
Patch foraging water rate 18 sec0.91.42.6-1.60.5-1.2
Patch foraging water rate 24 sec0.10.20.50.0-0.70.0
Patch foraging water rate 6 sec0.10.10.30.1-0.3-0.5
Seeking ratio, delayed vs. immediate footshock0.20.30.60.8-0.40.4
Distance traveled before self-admin0.10.20.3-0.50.3-0.4
Distance traveled after self-admin0.00.00.00.0-0.1-0.2
Extensor digitorum longus weight1.87.011.9-2.43.5-1.8
Bone: elastic displacement0.30.40.70.4-0.50.8
Bone: elastic work0.10.20.5-0.70.2-0.3
Bone: endosteal estimation0.00.10.2-0.10.5-0.1
Bone: endosteal perimeter0.10.20.40.60.10.4
Epididymis fat weight0.00.00.1-0.3-0.20.1
Delta time in closed arm before/after self-admin0.80.81.4-0.71.2-0.7
Delta time in open arm before/after self-admin0.30.30.5-0.50.7-0.2
Diff in mean of infusions in LGA sessions0.00.10.10.20.4-0.1
Delay discount exponential model param1.51.62.61.6-0.41.4
Extinction: sum of active levers before priming1.31.41.7-1.31.0-1.2
Active lever presses in extinction session 60.10.10.30.1-0.40.5
Bone: final force0.20.31.00.0-1.00.2
Bone: final moment0.20.30.8-0.1-0.9-0.1
Food consumed during 24 hour testing period1.31.82.4-1.21.6-1.3
Glucose0.40.60.8-0.9-0.5-0.8
Heart weight0.10.10.30.10.40.5
Delay discount hyperbolic model param1.71.92.91.7-0.51.5
Intermittent access intake day 1-15 change0.40.81.30.9-0.61.1
Intermittent access intake escalation0.51.01.51.0-0.61.2
Intermittent access intake escalation 21.21.32.21.2-0.71.5
Intermitt. access day 1 inactive lever presses0.00.00.1-0.1-0.00.3
Intermitt. access day 15 inactive lever presses1.22.53.31.5-1.41.8
Intermitt. access escalation Index0.20.30.6-0.80.4-0.3
Intermittent access day 1 total infusions0.10.10.2-0.30.2-0.5
Intermittent access day 15 total infusions0.00.10.10.2-0.10.4
Intermittent access terminal intake (last 3 days)0.70.91.40.8-0.71.2
Intermittent access total infusions0.00.00.1-0.20.1-0.1
Intermittent access day 1 locomotion0.10.10.1-0.30.0-0.3
Intermittent access day 15 total locomotion0.30.61.00.7-1.00.6
Intermittent access total locomotion0.81.01.60.8-1.30.9
Intermittent access standard deviation0.61.31.61.0-1.21.3
Left kidney weight1.56.98.8-3.02.2-2.7
Right kidney weight0.31.32.3-1.50.5-1.1
Cocaine induced anxiety0.20.30.9-0.41.0-0.0
Post-drug Anxiety0.20.20.20.50.20.4
Baseline Anxiety0.40.40.60.8-0.80.2
Tail length16.464.171.6-8.57.4-8.1
Length with tail12.052.357.8-7.67.0-7.1
Length without tail1.23.84.4-2.12.1-1.6
Times rat made contact with spout0.00.00.10.1-0.3-0.1
Lifetime Intake0.00.00.1-0.20.10.0
Liver weight, left0.10.20.3-0.50.6-0.2
Liver weight, right0.50.81.8-1.30.2-0.7
Locomotor activity1.11.82.01.4-1.41.2
Locomotor testing distance3.25.87.32.5-2.72.0
Locomotor testing rearing1.12.13.41.4-1.81.1
Locomotion in novel chamber0.40.50.8-0.9-0.1-0.8
Locomotion in novel chamber post-restriction1.52.43.21.6-1.31.8
Fecal boli incidents, locomotor time 11.31.92.41.5-1.11.5
Change in fecal boli incidents, locomotor task1.11.11.6-1.10.7-1.3
Time >=10cm from walls, locomotor time 10.10.20.20.4-0.30.5
Bouts of movement, locomotor time 10.10.10.1-0.30.3-0.3
Total resting periods, locomotor time 10.10.10.2-0.50.3-0.3
Rest time, locomotor task time 10.10.10.2-0.0-0.20.4
Distance moved, locomotor task time 10.50.71.1-0.80.5-1.0
Vertical activity count, locomotor time 10.10.20.4-0.20.3-0.6
Time >=10cm from walls, locomotor time 20.10.10.3-0.1-0.2-0.5
Bouts of movement, locomotor time 20.20.30.50.7-0.60.3
Total resting periods, locomotor time 20.20.30.60.8-0.50.5
Rest time, locomotor task time 20.30.41.1-0.11.00.2
Distance moved, locomotor task time 21.31.62.1-1.50.7-1.5
Vertical activity count, locomotor time 20.91.22.1-1.20.4-1.4
Light reinforcement 11.02.53.11.6-1.71.3
Light reinforcement 20.10.20.40.3-0.70.3
Bone: marrow area0.00.10.2-0.20.5-0.1
Bone: maximum diameter0.30.60.80.9-0.90.6
Bone: maximum force0.10.10.2-0.3-0.4-0.3
Bone: maximum moment0.10.20.3-0.5-0.4-0.5
Mean time between licks in bursts0.00.10.3-0.00.60.1
Mean num. licks in bursts0.10.20.3-0.50.3-0.6
Cd content in liver0.20.20.30.30.30.6
Co content in liver0.70.91.3-0.91.1-0.7
Cu content in liver0.60.71.7-0.41.3-0.4
Fe content in liver1.72.02.6-1.31.6-1.4
K content in liver0.20.20.4-0.50.3-0.6
Mg content in liver1.91.92.2-1.51.2-1.5
Mn content in liver0.70.71.2-0.71.1-0.7
Na content in liver1.51.61.91.4-1.21.3
Rb content in liver0.50.61.00.7-0.61.0
Se content in liver1.61.92.71.2-1.61.2
Sr content in liver3.53.03.6-1.91.7-1.6
Zn content in liver0.30.30.80.4-0.90.1
Bone: minimum diameter0.40.71.2-0.80.5-1.1
Time in familiar zone, hab. session 10.60.60.80.9-0.40.9
Time in novel zone, hab. session 11.31.32.21.0-1.50.9
Total zone transitions, hab. session 16.38.710.6-2.83.3-2.8
Total locomotion distance, hab. session 11.21.82.0-1.31.4-1.2
Locomotion velocity, hab. session 13.14.44.7-2.12.2-2.0
Time in familiar zone, hab. session 22.12.32.61.6-1.21.6
Time in novel zone, hab. session 20.80.81.1-1.00.4-1.0
Total zone transitions, hab. session 21.21.52.1-1.21.4-1.1
Total locomotion distance, hab. session 20.00.00.0-0.20.20.0
Locomotion velocity, hab. session 20.20.20.3-0.50.5-0.4
Novel to familiar place preference ratio3.03.33.7-1.81.7-1.9
Novelty place preference2.83.13.6-1.81.5-1.9
Time in novel zone, NPP test1.92.12.7-1.51.1-1.6
Total zone transitions, NPP test3.34.85.2-2.32.2-2.1
Total locomotion distance, NPP test0.60.91.0-1.00.9-0.9
Locomotion velocity, NPP test1.62.22.4-1.51.5-1.4
Intraocular pressure1.31.82.3-1.41.5-1.2
Delta distance traveled before/after self-admin0.10.10.30.5-0.20.3
Delta ambulatory time before/after self-admin0.10.10.10.4-0.30.1
Parametrial fat weight0.10.20.6-0.1-0.8-0.3
Pavlov. Cond. lever latency0.10.10.1-0.30.3-0.3
Pavlov. Cond. magazine entry latency2.83.65.31.7-2.31.6
Pavlov. Cond. change in total contacts0.50.51.00.6-1.00.5
Pavlov. Cond. index score1.72.13.01.3-1.71.2
Pavlov. Cond. latency score1.01.21.91.0-1.40.9
Pavlov. Cond. lever contacts0.20.20.30.5-0.40.5
Pavlov. Cond. magazine entry number3.44.36.0-1.92.5-1.8
Pavlov. Cond. intertrial magazine entries1.61.92.0-1.31.4-1.3
Pavlov. Cond. lever-magazine prob. diff.1.92.33.61.4-1.91.2
Pavlov. Cond. response bias2.22.73.61.6-1.91.5
Pavlov. Cond. lever latency0.30.40.6-0.50.8-0.5
Pavlov. Cond. magazine entry latency0.80.91.3-1.10.8-0.9
Pavlov. Cond. change in total contacts0.30.50.60.6-0.80.7
Pavlov. Cond. index score0.00.00.1-0.0-0.40.1
Pavlov. Cond. latency score0.00.10.1-0.3-0.1-0.2
Pavlov. Cond. lever contacts0.50.60.80.7-0.90.7
Pavlov. Cond. magazine entry number0.10.20.30.60.00.4
Pavlov. Cond. intertrial magazine entries1.32.03.3-1.11.8-1.2
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.1-0.30.1
Pavlov. Cond. response bias0.50.71.20.7-1.10.7
Time in closed arm before self-admin1.92.53.21.5-1.81.5
Time in closed arm after self-admin0.10.10.10.2-0.30.4
Time in open arm before self-admin0.40.41.1-0.31.0-0.3
Time in open arm after self-admin0.70.71.6-0.61.3-0.5
Bone: periosteal estimation0.00.00.10.1-0.30.0
Bone: periosteal perimeter0.00.10.10.3-0.10.1
Bone: post-yield work0.10.10.3-0.30.2-0.6
Progressive ratio test 1 active lever presses0.30.40.6-0.80.1-0.8
Progressive ratio test 1 breakpoint0.20.30.4-0.60.0-0.7
Progressive ratio test 1 inactive lever presses0.00.00.1-0.2-0.20.3
Progressive ratio test 2 active lever presses0.00.00.1-0.0-0.30.2
Progressive ratio test 2 breakpoint0.00.00.1-0.1-0.30.1
Progressive ratio test 2 inactive lever presses0.10.10.2-0.40.4-0.2
Incentive Sensitization - Responses0.20.30.50.3-0.50.7
Incentive Sensitization - Breakpoint0.20.30.50.2-0.50.7
Sum of active levers in priming session hrs 5-61.51.41.6-1.21.0-1.3
Progressive ratio0.10.20.4-0.20.6-0.1
Food seeking constrained by brief footshock0.50.61.10.8-1.00.6
Seeking ratio, punishment vs. effort0.20.20.60.3-0.7-0.0
Retroperitoneal fat weight0.10.51.30.0-1.10.3
Reaction time number correct0.30.60.9-0.61.0-0.7
Reaction time mean minus median0.00.10.10.20.10.4
Reaction time mean minus median AUC0.20.50.60.8-0.40.8
Reaction time num false alarms0.10.10.30.0-0.2-0.5
Reaction time num false alarms AUC0.10.20.5-0.2-0.0-0.7
Reaction time trials correct on left0.30.60.9-0.61.0-0.7
Reaction time trials on left0.30.60.9-0.60.9-0.7
Reaction time mean0.81.21.71.2-0.71.3
Reaction time mean AUC0.81.21.81.2-0.61.3
Median of all reaction times1.62.32.81.7-1.11.7
Reaction time omissions0.00.00.1-0.2-0.2-0.1
Reaction time false alarm rate0.10.20.40.3-0.6-0.2
Reaction time premature initiation rate0.20.30.9-1.00.2-0.2
Reaction time premature initiations0.61.11.8-1.30.9-0.8
Std. dev. reaction times0.10.10.20.3-0.20.5
Reaction time trials completed0.30.60.9-0.60.9-0.7
Reaction time trials AUC0.30.50.8-0.50.9-0.6
Run reversals in cocaine runway, females1.31.31.7-1.11.0-1.3
Run reversals in cocaine runway, males3.53.54.32.1-1.42.1
Latency to leave start box in cocaine runway0.40.50.80.8-0.20.9
Latency to leave start box in cocaine runway, F0.30.30.60.6-0.10.8
Latency to leave start box in cocaine runway, M0.10.10.20.4-0.10.4
Std. dev. time between licks in bursts0.60.81.21.0-0.61.1
Total sessions with >9 infusions0.00.10.1-0.4-0.1-0.0
Short access day 1 total inactive lever presses0.50.70.9-0.90.8-0.7
Short access day 10 total inactive lever presses0.61.52.11.5-0.31.5
Short access day 1 total infusions0.00.00.1-0.2-0.10.2
Short access day 10 total infusions0.20.30.50.3-0.70.5
Short access total infusions0.00.00.0-0.2-0.10.2
Short access day 1 locomotion0.80.91.30.4-1.21.1
Short access day 10 total locomotion1.83.34.61.8-2.11.4
Short access total locomotion0.60.81.00.7-1.00.9
One hour access (0.3 mA shock)0.00.00.1-0.20.3-0.1
Compulsive drug intake1.72.12.7-1.61.4-1.3
One hour access (shock baseline)0.61.01.11.1-0.90.9
Social response proportion2.02.33.3-1.60.9-1.8
Social responses0.20.20.5-0.40.0-0.7
Social time0.40.61.01.0-0.50.7
Soleus weight0.41.12.40.6-1.50.8
Bone: stiffness0.10.10.2-0.4-0.1-0.4
Tibialis anterior weight0.93.24.5-1.92.1-1.2
Time to tail flick, vehicle, before self-admin0.80.81.0-0.81.0-0.9
Time to tail flick, vehicle, after self-admin0.81.12.40.8-0.61.5
Time to tail flick, test, before self-admin0.10.10.20.4-0.00.4
Time to tail flick, test, after self-admin0.10.10.20.3-0.50.3
Delta time to tail flick, vehicle, before/after SA3.13.04.11.4-1.72.0
Delta time to tail flick, test, before/after SA0.20.20.4-0.6-0.2-0.4
Tibia length0.41.21.6-1.30.8-1.2
Ambulatory time before self-admin0.10.20.3-0.50.4-0.4
Ambulatory time after self-admin0.30.30.7-0.50.3-0.8
Bone: tissue strength0.10.10.10.00.3-0.3
Total heroin consumption0.00.00.10.00.2-0.3
Bone: trabecular number2.54.16.61.7-2.61.7
Bone: trabecular spacing0.10.10.40.10.60.1
Bone: trabecular thickness0.20.30.70.1-0.80.5
Bone: trabecular tissue density0.10.10.2-0.40.4-0.1
Water consumed over 24 hours0.00.00.1-0.10.3-0.1
Number of responses in last shaping day0.20.20.60.4-0.00.7