Hub : Genes

LOC134480823

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	intron excision ratio	chr10_61181793_61202406	0.03	0.03	6.9e-04	0.01	0.02	0.01	0.01	4.3e-03	1.4e-03	4.2e-02	6.9e-03
2	Adipose	alternative TSS	XR_010055679.1	0.11	0.07	1.8e-05	0.01	0.03	0.03	0.04	8.5e-03	1.4e-04	2.2e-04	7.6e-05
3	Brain	gene expression	LOC134480823	0.08	0.06	9.3e-04	0.03	0.02	0.02	0.03	4.6e-04	1.2e-02	3.3e-03	2.0e-03
4	Adipose	alternative TSS	XR_010055676.1	0.14	0.08	5.1e-07	0.01	0.06	0.05	0.05	1.0e-02	7.6e-07	3.3e-06	7.1e-06
5	Adipose	gene expression	LOC134480823	0.27	0.11	0.0e+00	0.17	0.21	0.21	0.22	2.2e-18	2.9e-23	2.3e-23	3.3e-24
6	Adipose	alternative TSS	XR_010055677.1	0.06	0.04	5.2e-05	0.01	0.04	0.03	0.03	8.2e-03	5.0e-05	9.5e-05	2.1e-04
7	Adipose	alternative TSS	XR_010055678.1	0.03	0.02	8.7e-03	0	0.01	0	0.01	1.1e-01	2.7e-02	8.5e-02	6.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	1.1	2.0	9.5	-3.1	1.2	-0.5	0.7	1.0	0.8	-0.8
Area under the delay curve	0.4	0.6	2.1	1.5	-0.8	1.1	-0.2	-0.3	-0.2	0.2
BMI with tail	0.3	1.0	4.3	-2.1	1.1	-1.0	0.7	0.1	0.4	-0.4
BMI without tail	0.7	3.7	6.0	-1.8	-0.9	1.1	2.5	2.2	2.3	-2.2
Body weight	2.6	11.3	15.9	-2.3	-2.2	2.9	4.0	3.7	3.9	-3.9
Weight adjusted by age	0.1	0.4	0.9	-0.7	0.9	-0.9	-0.3	-0.4	-0.4	0.4
Bone surface	0.8	1.7	8.3	-2.9	1.5	-0.7	0.3	0.4	0.3	-0.3
Bone volume	0.8	1.7	8.4	-2.9	1.6	-0.7	0.3	0.4	0.3	-0.4
Breakpoint value in progressive ratio session	0.7	1.3	1.8	-1.1	-0.5	0.5	1.3	1.3	1.3	-1.3
Number of licking bursts	0.1	0.3	0.9	1.0	-0.4	0.9	-0.4	-0.3	-0.0	-0.0
Context. condit. distance diff. score	0.4	0.5	2.1	-1.5	0.3	-0.6	0.4	0.4	0.5	-0.5
Locomotion velocity, session 1	1.5	1.7	4.2	-2.0	-0.1	0.2	1.4	1.4	1.4	-1.4
Locomotion distance, session 1	0.2	0.2	0.9	-1.0	0.8	-0.0	-0.1	-0.0	-0.1	0.1
Locomotion velocity, session 2	0.2	0.2	1.2	-1.1	0.5	-0.0	0.2	0.3	0.2	-0.2
Locomotion distance, session 2	0.4	0.6	2.8	-1.7	1.1	-0.3	-0.0	0.3	-0.1	0.1
Locomotion velocity, session 3	1.8	2.0	6.8	2.6	-1.6	2.1	0.3	-0.1	0.2	-0.1
Locomotion distance, session 3	0.2	0.2	0.4	0.1	0.6	0.2	-0.3	-0.5	-0.5	0.6
Stereotopy head waving bouts, day 3	0.5	0.6	1.1	0.1	-0.7	1.0	0.8	0.8	0.9	-0.9
Stereotopy head waving duration, day 3	0.1	0.2	0.4	0.6	0.1	0.5	-0.4	-0.5	-0.2	0.2
Locomotion velocity, session 7	0.5	0.6	1.3	-1.1	1.1	-1.2	-0.1	-0.3	-0.4	0.4
Locomotion distance, session 7	0.7	0.8	2.4	-1.6	1.2	-1.3	-0.1	-0.1	-0.3	0.3
Stereotopy head waving bouts, day 7	0.5	0.6	0.9	-1.0	0.1	0.7	0.7	0.7	0.8	-0.8
Stereotopy head waving duration, day 7	0.3	0.4	1.5	-1.2	0.5	0.5	0.4	0.4	0.5	-0.6
Locomotion velocity, session 8	0.3	0.4	0.8	-0.8	0.7	-0.9	-0.3	-0.5	-0.4	0.4
Locomotion distance, session 8	0.7	1.1	4.2	-2.1	0.4	0.0	0.9	0.9	0.9	-0.9
Degree of sensitization distance	0.6	0.6	1.5	-1.2	-0.0	-0.7	0.6	0.9	0.7	-0.7
Degree of sensitization stereotypy	0.5	0.6	1.5	-1.2	0.1	0.5	0.7	0.7	0.8	-0.9
Conditioned locomotion	0.3	0.4	0.6	0.6	0.3	-0.6	-0.8	-0.6	-0.7	0.6
Cocaine response after cond. corrected	0.2	0.3	0.5	-0.3	-0.6	0.1	0.6	0.7	0.7	-0.7
Cocaine response after cond. not corrected	0.4	0.5	0.8	-0.7	-0.5	0.2	0.8	0.8	0.9	-0.9
Cocaine response before conditioning	0.2	0.3	1.4	-1.2	0.5	0.1	0.5	0.2	0.4	-0.3
Saline control response	0.2	0.3	0.8	-0.6	0.9	0.0	-0.4	-0.5	-0.4	0.4
Bone: connectivity density	1.6	2.5	12.3	-3.5	1.7	-0.9	0.6	0.9	0.5	-0.5
Bone: cortical apparent density	0.7	1.2	1.7	0.6	0.8	-1.0	-1.3	-1.1	-1.2	1.2
Bone: cortical area	0.5	0.8	3.2	1.8	-1.1	0.9	0.1	-0.2	-0.1	0.2
Bone: cortical porosity	0.1	0.1	0.2	-0.4	-0.1	0.1	0.4	0.2	0.4	-0.4
Bone: cortical porosity	0.1	0.1	0.1	0.1	-0.3	0.2	0.3	0.0	0.3	-0.3
Bone: cortical thickness	1.9	3.2	10.9	3.3	-2.5	2.2	0.5	0.2	0.3	-0.2
Bone: cortical thickness	1.2	1.4	2.9	1.1	-1.7	1.6	1.0	0.8	0.9	-0.9
Bone: cortical tissue density	0.6	0.9	1.3	0.4	0.8	-1.0	-1.2	-1.0	-1.1	1.1
Condit. Reinf. active minus inactive responses	0.4	0.5	0.9	0.5	-0.7	1.0	0.7	0.5	0.6	-0.6
Condit. Reinf. active-inactive response ratio	2.8	3.0	5.4	1.5	-2.2	2.3	1.5	1.4	1.4	-1.4
Condit. Reinf. active responses	0.1	0.1	0.3	-0.5	0.5	-0.5	0.0	-0.0	0.0	-0.0
Condit. Reinf. inactive responses	3.6	4.6	9.5	-1.8	2.8	-3.1	-1.8	-1.7	-1.7	1.6
Incentive salience index mean	0.5	0.7	1.1	0.2	-0.8	1.0	1.1	0.7	0.9	-0.9
Condit. Reinf. lever presses	0.9	1.3	2.6	-0.8	-0.8	0.6	1.6	1.1	1.4	-1.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	-0.7	0.6	-0.3	0.0	0.1	-0.0	0.0
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.3	0.2	-0.6	0.5	0.6	0.5	0.6	-0.5
Condit. Reinf. active responses	0.5	0.8	2.2	-1.0	1.5	-0.7	-0.6	-0.7	-0.6	0.6
Condit. Reinf. inactive responses	2.1	3.1	6.8	-1.3	2.6	-1.6	-1.6	-1.8	-1.6	1.6
Condit. Reinf. lever presses	1.1	1.7	3.2	0.6	1.2	-0.8	-1.4	-1.8	-1.4	1.4
Condit. Reinf. lever reinforcers received	0.6	0.9	2.4	-0.9	1.5	-0.8	-0.7	-0.8	-0.8	0.8
Conditioned reinforcement - actives	0.3	1.2	2.5	-1.6	1.5	-1.6	-0.5	-0.4	-0.5	0.5
Conditioned reinforcement - inactives	0.0	0.1	0.4	-0.6	0.6	-0.4	-0.1	-0.2	-0.1	0.1
Conditioned locomotion	0.3	0.5	0.8	0.7	0.3	-0.1	-0.7	-0.8	-0.8	0.9
Patch foraging indifference point 0 sec	0.0	0.1	0.3	-0.6	0.5	-0.3	-0.0	-0.4	-0.2	0.3
Patch foraging indifference point AUC	0.3	0.8	1.2	0.4	1.0	-0.5	-1.1	-0.9	-1.0	1.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.2	0.2	0.3	0.1	0.3	0.2	-0.2
Delay disc. indifference point, 16s delay	0.4	0.6	2.0	1.4	-0.7	1.0	-0.4	-0.4	-0.3	0.2
Delay disc. indifference point, 2s delay	0.4	0.4	1.4	1.2	-0.7	1.0	-0.2	-0.3	-0.1	0.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.4	0.6	-0.2	0.1	-0.2	-0.3	-0.2	0.3
Delay disc. indifference point, 4s delay	0.6	0.7	1.9	1.1	-1.0	1.4	0.3	0.2	0.4	-0.4
Delay disc. indifference point, 8s delay	0.2	0.3	1.1	1.1	-0.8	0.8	0.0	-0.2	0.1	-0.0
Indifference point function ln k	0.1	0.3	1.2	-1.1	0.2	-0.3	0.4	0.2	0.3	-0.3
Indifference point function log k	0.1	0.3	1.2	-1.1	0.2	-0.3	0.4	0.2	0.3	-0.3
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.6	0.6	-0.5	-0.1	-0.4	-0.3	0.4
Patch foraging total patch changes 12 sec	0.1	0.2	0.5	0.7	-0.5	0.7	0.3	0.1	0.1	-0.1
Patch foraging total patch changes 18 sec	0.3	0.7	2.6	1.0	-0.8	1.6	0.4	0.2	0.4	-0.4
Patch foraging total patch changes 24 sec	0.1	0.2	0.8	0.9	-0.2	0.6	-0.2	-0.3	-0.3	0.3
Patch foraging total patch changes 6 sec	0.6	0.9	1.9	0.3	1.0	-0.6	-1.0	-1.4	-1.1	1.1
Patch foraging time to switch 0 sec	0.6	2.3	4.7	1.1	-2.2	1.7	1.4	1.2	1.5	-1.5
Patch foraging water rate 0 sec	0.4	1.6	2.7	-0.4	1.6	-1.2	-1.3	-1.2	-1.4	1.4
Patch foraging water rate 12 sec	0.0	0.0	0.2	-0.1	-0.2	0.4	0.1	0.0	0.1	-0.1
Patch foraging water rate 18 sec	0.4	1.0	3.9	-2.0	1.4	-1.0	-0.3	-0.2	-0.2	0.1
Patch foraging water rate 24 sec	0.3	0.4	0.8	-0.3	0.9	-0.5	-0.6	-0.9	-0.7	0.7
Patch foraging water rate 6 sec	0.4	0.5	0.9	0.6	0.5	-0.2	-0.8	-0.8	-0.9	1.0
Seeking ratio, delayed vs. immediate footshock	0.7	1.0	1.7	1.3	0.3	-0.0	-1.2	-1.2	-1.1	1.1
Distance traveled before self-admin	0.7	1.4	5.8	2.4	-0.7	0.9	-1.0	-0.8	-0.8	0.8
Distance traveled after self-admin	0.1	0.2	0.7	0.8	-0.4	0.4	-0.1	-0.0	-0.1	0.1
Extensor digitorum longus weight	1.8	7.0	23.3	-4.8	4.0	-2.9	-0.7	-0.2	-0.7	0.7
Bone: elastic displacement	0.5	0.7	1.2	0.8	0.4	-0.4	-0.9	-1.1	-0.9	0.9
Bone: elastic work	1.4	1.9	7.3	2.7	-1.6	1.7	0.2	-0.4	-0.1	0.2
Bone: endosteal estimation	0.1	0.2	0.3	-0.6	0.6	-0.2	-0.3	-0.3	-0.3	0.3
Bone: endosteal perimeter	0.7	1.7	3.1	-1.3	1.8	-1.7	-1.1	-0.9	-1.1	1.0
Epididymis fat weight	1.8	9.2	31.3	-5.6	1.0	-0.3	2.6	2.9	2.8	-2.9
Delta time in closed arm before/after self-admin	1.1	1.0	2.2	0.9	0.6	-0.4	-1.5	-1.0	-1.2	1.1
Delta time in open arm before/after self-admin	0.5	0.6	1.2	-1.1	-0.1	0.2	1.1	0.6	0.8	-0.8
Diff in mean of infusions in LGA sessions	0.5	0.9	1.7	-1.3	-0.2	-0.2	1.1	1.1	1.0	-1.0
Delay discount exponential model param	0.4	0.5	1.8	-1.3	0.8	-1.0	0.1	0.2	0.1	-0.1
Extinction: sum of active levers before priming	0.7	1.0	3.0	-1.7	1.5	-1.3	-0.3	-0.3	-0.4	0.4
Active lever presses in extinction session 6	0.7	0.7	2.8	-1.7	1.0	-1.0	0.1	0.1	0.1	-0.1
Bone: final force	1.6	2.6	5.2	1.0	-2.0	2.3	1.8	1.1	1.3	-1.2
Bone: final moment	1.1	1.8	3.7	1.0	-1.7	1.9	1.5	0.8	1.1	-0.9
Food consumed during 24 hour testing period	0.1	0.1	0.4	-0.6	0.2	-0.4	0.4	0.1	0.2	-0.1
Glucose	1.1	1.8	7.8	2.8	-1.0	1.1	-0.8	-0.7	-0.8	0.8
Heart weight	1.3	2.1	3.9	-1.5	-0.5	0.9	1.6	2.0	1.5	-1.5
Delay discount hyperbolic model param	0.5	0.7	2.1	-1.5	1.0	-1.2	0.0	0.2	-0.0	-0.0
Intermittent access intake day 1-15 change	0.3	1.7	2.3	0.4	1.3	-1.2	-1.5	-1.4	-1.5	1.5
Intermittent access intake escalation	0.4	1.9	2.6	0.4	1.4	-1.3	-1.5	-1.5	-1.6	1.6
Intermittent access intake escalation 2	1.1	1.9	2.7	0.6	1.2	-1.2	-1.6	-1.5	-1.6	1.6
Intermitt. access day 1 inactive lever presses	0.2	2.0	2.9	1.6	0.6	-0.6	-1.5	-1.6	-1.7	1.7
Intermitt. access day 15 inactive lever presses	0.6	3.3	5.1	1.5	1.0	-1.4	-2.3	-2.1	-2.1	2.0
Intermitt. access escalation Index	0.9	3.0	5.0	-0.5	-1.6	1.4	1.8	2.2	1.9	-2.0
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.2	0.0	0.2	-0.1	-0.4	-0.1	0.1
Intermittent access day 15 total infusions	0.5	1.2	1.8	-0.2	1.3	-1.1	-1.1	-1.2	-1.1	1.1
Intermittent access terminal intake (last 3 days)	0.4	0.7	1.5	-0.8	1.2	-1.1	-0.7	-0.7	-0.6	0.6
Intermittent access total infusions	0.5	0.6	0.9	-0.1	0.9	-0.7	-0.8	-1.0	-0.8	0.8
Intermittent access day 1 locomotion	0.2	0.3	1.2	0.8	-0.6	1.1	0.3	-0.1	0.2	-0.1
Intermittent access day 15 total locomotion	0.1	0.3	0.5	0.6	0.3	0.0	-0.6	-0.7	-0.7	0.7
Intermittent access total locomotion	0.2	0.2	0.3	0.3	0.4	0.1	-0.4	-0.6	-0.5	0.6
Intermittent access standard deviation	0.9	4.6	5.5	0.0	2.3	-2.2	-2.3	-2.3	-2.3	2.3
Left kidney weight	1.0	8.3	18.1	2.7	-3.8	4.3	2.2	2.0	2.2	-2.1
Right kidney weight	1.4	9.5	19.1	2.2	-4.0	4.4	2.7	2.5	2.7	-2.6
Cocaine induced anxiety	0.1	0.3	0.5	0.3	0.4	-0.2	-0.7	-0.7	-0.6	0.6
Post-drug Anxiety	0.5	0.6	0.9	-0.7	-0.4	0.7	0.7	0.8	0.9	-0.9
Baseline Anxiety	0.7	1.1	1.6	-1.2	-0.5	0.4	1.2	1.2	1.2	-1.3
Tail length	2.5	13.2	17.8	-0.9	-3.3	3.9	3.9	4.2	4.0	-4.0
Length with tail	3.6	16.0	20.4	-0.5	-3.9	4.5	4.2	4.5	4.4	-4.4
Length without tail	0.8	3.9	5.5	-0.8	-1.6	2.2	2.1	2.0	2.3	-2.4
Times rat made contact with spout	1.4	1.6	2.9	1.2	-1.7	1.7	1.2	0.9	1.0	-0.9
Lifetime Intake	0.4	0.5	0.9	-0.1	0.8	-0.6	-0.7	-0.9	-0.8	0.8
Liver weight, left	6.8	11.7	16.5	-2.0	-2.7	2.6	3.9	4.0	4.0	-4.1
Liver weight, right	4.7	8.2	11.8	-2.0	-2.0	2.1	3.3	3.3	3.4	-3.4
Locomotor activity	0.0	0.0	0.1	-0.3	0.2	0.1	0.1	0.1	0.2	-0.2
Locomotor testing distance	0.0	0.0	0.0	-0.2	0.2	0.2	-0.0	0.1	0.1	-0.1
Locomotor testing rearing	0.1	0.5	1.2	-0.6	1.1	-0.6	-0.8	-0.6	-0.7	0.6
Locomotion in novel chamber	4.2	5.7	8.3	1.3	1.9	-1.8	-2.7	-2.9	-2.8	2.8
Locomotion in novel chamber post-restriction	0.2	0.7	1.2	-0.5	1.1	-0.9	-0.7	-0.8	-0.8	0.8
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	-0.1	-0.3	0.6	0.4	0.4	0.4	-0.4
Change in fecal boli incidents, locomotor task	0.2	0.3	0.8	0.6	-0.9	0.2	0.4	0.4	0.4	-0.4
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.7	-0.5	0.6	-0.8	0.1	-0.3	-0.3	0.4
Bouts of movement, locomotor time 1	0.1	0.1	0.5	-0.3	0.2	-0.7	0.0	-0.2	-0.1	0.1
Total resting periods, locomotor time 1	0.2	0.3	1.2	-0.3	0.4	-1.1	-0.2	-0.5	-0.3	0.3
Rest time, locomotor task time 1	0.5	0.7	1.5	0.5	0.4	-1.2	-0.9	-1.1	-0.9	0.8
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.3	0.2	0.3	0.0	0.2	-0.0	0.0
Vertical activity count, locomotor time 1	0.0	0.2	0.9	-0.9	0.6	-0.3	0.1	0.2	0.0	-0.0
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.7	0.8	-0.5	0.2	0.5	-0.1	-0.0	0.1
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.3	-0.3	-0.0	-0.0	-0.1	0.1	-0.1
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.0	-0.1	0.1	-0.1
Rest time, locomotor task time 2	0.2	0.4	1.4	-0.5	0.5	-1.2	-0.6	-0.5	-0.3	0.3
Distance moved, locomotor task time 2	0.3	0.4	0.8	0.6	0.5	0.0	-0.7	-0.9	-0.7	0.7
Vertical activity count, locomotor time 2	0.1	0.2	0.5	0.7	-0.5	0.6	0.0	0.0	0.1	-0.1
Light reinforcement 1	0.0	0.0	0.3	-0.0	0.1	0.5	-0.0	-0.1	0.1	-0.1
Light reinforcement 2	0.7	1.6	3.7	1.9	-1.8	1.9	0.5	0.5	0.6	-0.5
Bone: marrow area	0.1	0.1	0.3	-0.6	0.5	-0.2	-0.3	-0.3	-0.3	0.3
Bone: maximum diameter	0.4	0.8	1.3	-0.0	0.8	-1.1	-0.8	-0.9	-1.0	1.1
Bone: maximum force	1.0	2.1	4.4	1.3	-1.9	2.1	1.4	0.9	1.1	-0.9
Bone: maximum moment	0.7	1.3	2.9	1.2	-1.5	1.7	1.1	0.6	0.7	-0.6
Mean time between licks in bursts	0.2	1.4	2.0	-0.3	-1.0	1.4	1.2	1.3	1.3	-1.3
Mean num. licks in bursts	0.2	0.6	1.5	-0.1	-0.8	0.2	1.2	0.9	0.8	-0.6
Cd content in liver	1.3	1.4	2.4	-0.8	1.5	-1.5	-1.5	-0.7	-1.1	1.0
Co content in liver	0.0	0.0	0.1	0.3	-0.1	-0.0	0.1	-0.1	-0.1	0.1
Cu content in liver	0.2	0.2	1.2	1.1	-0.6	0.1	-0.1	-0.2	-0.2	0.2
Fe content in liver	0.8	1.0	1.5	-0.3	-1.0	0.8	1.1	1.1	1.2	-1.2
K content in liver	2.0	2.0	2.7	0.3	-1.5	1.5	1.6	1.6	1.5	-1.4
Mg content in liver	0.1	0.1	0.3	-0.3	0.5	-0.5	-0.1	-0.0	-0.2	0.3
Mn content in liver	0.7	0.8	1.8	-0.7	1.2	-1.3	-0.7	-0.7	-0.8	0.8
Na content in liver	1.2	1.3	3.4	1.8	-1.5	1.7	0.5	0.1	0.5	-0.5
Rb content in liver	1.7	1.9	4.6	-2.1	1.9	-2.1	-0.5	-0.1	-0.6	0.6
Se content in liver	0.2	0.2	0.7	0.8	-0.5	0.5	0.1	-0.1	0.0	-0.0
Sr content in liver	1.2	1.0	2.4	-1.2	1.3	-1.6	-0.6	-0.7	-0.6	0.6
Zn content in liver	0.3	0.4	0.6	-0.6	-0.4	0.0	0.8	0.7	0.7	-0.7
Bone: minimum diameter	0.5	1.0	2.1	1.2	-1.5	1.3	0.6	0.6	0.6	-0.6
Time in familiar zone, hab. session 1	2.1	2.3	4.5	-1.0	1.8	-2.1	-1.3	-1.3	-1.4	1.4
Time in novel zone, hab. session 1	1.7	1.9	4.1	1.0	-1.6	2.0	1.1	1.1	1.2	-1.2
Total zone transitions, hab. session 1	1.1	1.6	4.3	-1.2	2.1	-0.7	-1.3	-0.9	-1.1	1.1
Total locomotion distance, hab. session 1	0.2	0.3	1.0	-0.8	1.0	0.3	-0.5	-0.1	-0.3	0.2
Locomotion velocity, hab. session 1	0.3	0.4	1.4	-0.9	1.2	-0.1	-0.7	-0.4	-0.5	0.4
Time in familiar zone, hab. session 2	0.6	0.7	1.9	-1.4	1.3	-0.4	-0.7	-0.5	-0.5	0.4
Time in novel zone, hab. session 2	1.6	1.7	4.8	2.2	-2.1	1.0	0.8	0.7	0.6	-0.5
Total zone transitions, hab. session 2	0.2	0.3	1.1	-1.1	0.8	0.4	0.1	0.2	0.2	-0.2
Total locomotion distance, hab. session 2	0.2	0.2	1.0	-0.3	-0.0	1.0	0.3	0.4	0.4	-0.4
Locomotion velocity, hab. session 2	0.1	0.2	0.9	-0.2	-0.0	0.9	0.2	0.3	0.3	-0.3
Novel to familiar place preference ratio	0.6	0.8	1.9	0.2	0.6	-1.4	-0.7	-0.8	-0.9	1.0
Novelty place preference	0.2	0.3	1.1	0.1	0.2	-1.0	-0.3	-0.4	-0.5	0.5
Time in novel zone, NPP test	0.1	0.2	0.9	-0.2	0.3	-0.9	-0.2	-0.2	-0.3	0.3
Total zone transitions, NPP test	0.4	0.6	2.2	-1.1	1.5	0.1	-0.7	-0.3	-0.5	0.5
Total locomotion distance, NPP test	0.4	0.6	1.3	-0.2	1.1	0.4	-1.0	-0.8	-0.8	0.7
Locomotion velocity, NPP test	0.7	1.1	1.8	0.2	1.2	-0.0	-1.4	-1.2	-1.2	1.1
Intraocular pressure	2.0	3.3	4.8	0.1	1.9	-1.9	-2.2	-1.9	-2.0	1.9
Delta distance traveled before/after self-admin	0.8	0.9	3.0	-1.7	0.2	-0.5	1.0	0.9	0.8	-0.8
Delta ambulatory time before/after self-admin	0.5	0.8	2.9	-1.7	0.4	-0.8	0.8	0.8	0.7	-0.7
Parametrial fat weight	3.1	7.2	21.5	-4.6	0.4	-0.1	2.6	2.6	2.7	-2.8
Pavlov. Cond. lever latency	0.6	0.8	1.3	-0.3	1.1	-0.7	-1.1	-0.7	-1.0	0.9
Pavlov. Cond. magazine entry latency	0.7	0.9	1.5	-0.5	-0.9	0.2	1.2	1.1	1.1	-1.1
Pavlov. Cond. change in total contacts	0.2	0.3	1.0	1.0	-0.8	0.4	0.2	0.1	0.2	-0.2
Pavlov. Cond. index score	0.9	1.1	2.1	-0.3	-1.1	0.5	1.5	1.1	1.3	-1.2
Pavlov. Cond. latency score	1.4	1.8	3.1	-0.2	-1.4	0.9	1.8	1.3	1.6	-1.5
Pavlov. Cond. lever contacts	0.5	0.6	1.1	0.3	-1.1	0.6	1.0	0.6	0.9	-0.8
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	0.3	0.3	0.3	-0.5	-0.5	-0.4	0.4
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.9	-0.2	1.4	-0.6	-1.3	-1.2	-1.1	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.5	-0.3	-0.9	0.2	1.2	0.9	1.1	-1.0
Pavlov. Cond. response bias	0.4	0.5	0.9	-0.4	-0.7	-0.0	0.9	0.8	0.8	-0.8
Pavlov. Cond. lever latency	0.6	0.8	2.7	-1.6	0.3	-0.5	0.8	1.0	0.7	-0.8
Pavlov. Cond. magazine entry latency	1.0	1.4	3.8	1.4	-1.5	1.9	0.6	0.7	0.7	-0.6
Pavlov. Cond. change in total contacts	0.2	0.5	2.1	1.4	-0.7	1.1	-0.1	-0.2	-0.2	0.2
Pavlov. Cond. index score	0.6	1.0	3.7	1.9	-0.6	1.0	-0.7	-0.7	-0.6	0.6
Pavlov. Cond. latency score	0.7	1.1	4.2	2.0	-0.5	1.0	-0.8	-0.9	-0.7	0.8
Pavlov. Cond. lever contacts	0.3	0.4	1.6	1.3	-0.6	0.8	-0.2	-0.5	-0.2	0.2
Pavlov. Cond. magazine entry number	0.9	1.2	3.2	-1.5	1.4	-1.8	-0.4	-0.5	-0.4	0.4
Pavlov. Cond. intertrial magazine entries	0.5	1.2	3.6	-1.9	1.6	-1.3	-0.3	-0.4	-0.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	3.4	1.8	-0.6	0.9	-0.7	-0.7	-0.6	0.6
Pavlov. Cond. response bias	0.5	0.7	2.5	1.6	-1.0	1.2	-0.1	-0.2	0.0	0.0
Time in closed arm before self-admin	1.0	1.8	2.5	-1.5	-0.5	0.9	1.6	1.5	1.5	-1.5
Time in closed arm after self-admin	0.1	0.2	0.6	0.7	-0.5	0.5	-0.1	0.1	0.1	-0.1
Time in open arm before self-admin	1.2	1.5	5.2	2.3	-0.5	0.4	-1.1	-1.3	-1.0	1.0
Time in open arm after self-admin	0.4	0.5	0.9	0.9	0.1	-0.4	-0.5	-0.9	-0.7	0.8
Bone: periosteal estimation	0.1	0.3	0.7	0.8	-0.7	0.9	0.2	0.0	0.1	-0.0
Bone: periosteal perimeter	0.1	0.2	0.4	0.3	0.3	-0.3	-0.4	-0.5	-0.6	0.6
Bone: post-yield work	0.4	0.7	1.4	-0.8	-0.5	0.4	1.0	1.2	0.9	-0.9
Progressive ratio test 1 active lever presses	0.2	0.3	0.7	0.3	0.4	-0.4	-0.6	-0.8	-0.6	0.6
Progressive ratio test 1 breakpoint	0.2	0.4	0.7	0.2	0.5	-0.5	-0.7	-0.9	-0.7	0.7
Progressive ratio test 1 inactive lever presses	0.5	1.4	2.4	1.6	0.3	-0.3	-1.2	-1.4	-1.3	1.3
Progressive ratio test 2 active lever presses	1.2	1.7	2.7	-0.5	1.6	-1.6	-1.2	-1.4	-1.2	1.2
Progressive ratio test 2 breakpoint	1.3	1.7	2.7	-0.6	1.6	-1.6	-1.1	-1.3	-1.2	1.2
Progressive ratio test 2 inactive lever presses	0.5	1.6	2.2	0.3	1.3	-1.2	-1.4	-1.5	-1.5	1.5
Incentive Sensitization - Responses	0.6	1.5	3.1	-0.9	1.8	-1.6	-1.0	-1.0	-1.0	1.0
Incentive Sensitization - Breakpoint	0.6	1.3	2.7	-0.9	1.6	-1.5	-0.9	-0.8	-0.9	0.9
Sum of active levers in priming session hrs 5-6	1.6	1.5	2.8	-1.7	-0.3	-0.0	1.5	1.4	1.3	-1.3
Progressive ratio	0.3	0.8	1.3	0.2	0.8	-1.0	-0.8	-1.1	-1.0	1.0
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.2	0.1	0.2	-0.3	-0.2	-0.2	0.2
Seeking ratio, punishment vs. effort	0.5	1.0	2.6	0.8	-1.2	1.6	0.5	0.9	0.8	-0.8
Retroperitoneal fat weight	0.1	0.4	0.8	-0.8	-0.0	0.6	0.4	0.4	0.8	-0.9
Reaction time number correct	0.0	0.1	0.1	-0.3	0.0	0.3	0.4	0.1	0.3	-0.3
Reaction time mean minus median	0.1	0.8	1.5	0.1	0.9	-1.2	-1.1	-0.7	-1.0	0.9
Reaction time mean minus median AUC	0.2	1.6	3.1	-0.9	1.8	-1.7	-1.3	-0.9	-1.1	1.0
Reaction time num false alarms	1.3	2.1	3.1	-0.0	1.8	-1.1	-1.8	-1.5	-1.6	1.6
Reaction time num false alarms AUC	0.9	2.0	2.9	-0.0	1.7	-1.1	-1.6	-1.4	-1.6	1.6
Reaction time trials correct on left	0.0	0.1	0.1	-0.3	0.0	0.3	0.4	0.1	0.3	-0.3
Reaction time trials on left	0.0	0.1	0.1	-0.3	0.1	0.2	0.3	0.0	0.3	-0.3
Reaction time mean	0.1	0.1	0.3	0.2	0.0	-0.6	-0.5	0.1	-0.3	0.3
Reaction time mean AUC	0.2	0.4	0.7	0.5	0.3	-0.8	-0.9	-0.3	-0.7	0.7
Median of all reaction times	0.0	0.1	0.1	0.4	-0.3	-0.1	-0.2	0.3	-0.0	0.0
Reaction time omissions	0.0	0.0	0.1	-0.3	0.2	-0.2	0.0	0.2	-0.0	0.0
Reaction time false alarm rate	1.2	1.7	2.4	-0.0	1.5	-1.1	-1.5	-1.2	-1.5	1.5
Reaction time premature initiation rate	0.2	0.4	0.8	-0.9	0.9	-0.8	-0.2	-0.2	-0.3	0.3
Reaction time premature initiations	0.1	0.4	1.0	-1.0	1.0	-0.7	-0.2	-0.4	-0.3	0.3
Std. dev. reaction times	0.3	0.9	1.7	0.0	0.9	-1.3	-1.0	-0.7	-1.0	1.0
Reaction time trials completed	0.0	0.1	0.1	-0.3	0.1	0.2	0.3	0.0	0.3	-0.3
Reaction time trials AUC	0.0	0.0	0.1	-0.3	0.1	0.2	0.3	0.0	0.2	-0.2
Run reversals in cocaine runway, females	1.1	1.3	1.9	0.1	1.1	-1.0	-1.4	-1.3	-1.2	1.2
Run reversals in cocaine runway, males	0.9	1.0	1.9	-0.6	1.4	-1.1	-1.0	-0.8	-0.9	0.9
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.4	-0.6	0.5	0.3	0.2	0.3	-0.2
Latency to leave start box in cocaine runway, F	0.5	0.6	0.9	0.1	-1.0	0.9	0.9	0.6	0.8	-0.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	0.1	-0.2	-0.3	-0.1	-0.3	0.3
Std. dev. time between licks in bursts	0.1	0.1	0.3	-0.5	0.5	-0.4	-0.1	-0.3	-0.1	0.1
Total sessions with >9 infusions	0.6	0.8	1.3	-0.0	0.9	-0.8	-0.9	-1.1	-0.9	0.9
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.3	0.2	-0.3	0.3	-0.0	0.0	-0.0
Short access day 10 total inactive lever presses	0.1	0.4	1.1	1.0	-0.1	-0.1	-0.4	-0.7	-0.6	0.7
Short access day 1 total infusions	0.7	1.5	2.9	0.6	0.9	-0.9	-1.2	-1.7	-1.4	1.4
Short access day 10 total infusions	0.6	1.0	1.6	0.3	1.0	-0.8	-1.2	-1.3	-1.1	1.1
Short access total infusions	0.8	1.1	2.3	0.6	0.7	-0.6	-1.1	-1.5	-1.2	1.2
Short access day 1 locomotion	0.7	1.1	2.0	1.4	0.1	-0.2	-1.0	-1.3	-1.1	1.2
Short access day 10 total locomotion	0.2	0.7	1.3	1.2	0.3	-0.1	-0.8	-0.9	-1.0	1.1
Short access total locomotion	1.1	1.7	2.7	1.6	0.4	-0.1	-1.3	-1.6	-1.5	1.5
One hour access (0.3 mA shock)	0.9	1.1	2.3	-1.0	1.4	-1.5	-0.7	-0.9	-0.7	0.7
Compulsive drug intake	0.8	1.1	1.8	-0.8	-0.8	0.4	1.3	1.2	1.2	-1.2
One hour access (shock baseline)	0.2	0.6	1.0	0.1	0.8	-0.7	-0.9	-1.0	-0.8	0.8
Social response proportion	2.5	3.2	5.4	-1.4	-1.2	0.7	2.2	2.3	2.0	-2.0
Social responses	1.1	1.5	2.8	-1.5	-0.1	0.2	1.5	1.7	1.3	-1.3
Social time	0.9	1.4	3.8	-2.0	0.3	-0.3	1.1	1.4	1.1	-1.2
Soleus weight	2.2	6.3	11.5	-3.4	-0.3	1.3	2.7	3.0	2.7	-2.8
Bone: stiffness	1.3	2.4	3.7	-1.0	-1.1	1.3	1.9	1.9	1.7	-1.6
Tibialis anterior weight	2.5	8.6	35.8	-6.0	3.8	-3.1	0.3	0.3	0.1	-0.1
Time to tail flick, vehicle, before self-admin	1.6	1.9	8.8	-3.0	1.4	-1.1	0.6	0.7	0.6	-0.6
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.5	-0.7	0.4	-0.6	0.1	0.1	0.1	-0.1
Time to tail flick, test, before self-admin	0.4	0.5	1.0	-1.0	-0.1	0.3	0.8	0.8	0.8	-0.7
Time to tail flick, test, after self-admin	0.2	0.2	0.5	0.3	-0.7	0.4	0.4	0.3	0.5	-0.5
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.4	1.2	0.0	-0.3	-0.8	-0.9	-0.8	0.8
Delta time to tail flick, test, before/after SA	0.5	0.6	0.9	0.6	0.5	-0.7	-0.9	-1.0	-0.9	0.9
Tibia length	1.7	4.7	7.1	0.4	-2.7	2.2	2.4	2.3	2.3	-2.2
Ambulatory time before self-admin	0.6	1.8	7.2	2.7	-1.5	1.8	-0.4	-0.3	-0.2	0.2
Ambulatory time after self-admin	0.6	1.0	1.8	0.6	-1.3	1.2	0.9	0.9	1.0	-1.0
Bone: tissue strength	0.8	0.8	2.8	1.7	-1.2	1.0	0.4	0.3	0.2	-0.2
Total heroin consumption	1.8	2.1	6.3	-2.5	0.3	-0.5	1.5	1.5	1.3	-1.3
Bone: trabecular number	1.1	2.0	9.8	-3.1	1.4	-0.7	0.5	0.8	0.6	-0.7
Bone: trabecular spacing	0.2	0.3	1.1	1.1	-0.2	-0.1	-0.3	-0.5	-0.5	0.6
Bone: trabecular thickness	0.1	0.2	0.7	-0.8	0.4	0.2	0.3	0.4	0.3	-0.3
Bone: trabecular tissue density	0.5	0.8	4.0	2.0	-0.8	0.5	-0.6	-0.5	-0.5	0.5
Water consumed over 24 hours	0.8	1.5	2.6	0.7	-1.6	1.5	1.3	1.0	1.2	-1.2
Number of responses in last shaping day	1.1	1.4	2.7	1.4	0.5	-0.4	-1.2	-1.6	-1.3	1.4