Hub : Genes

LOC134480367

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	XR_010054783.1	0.54	0.2	6.5e-04	-0	0.01	0.01	-0	3.9e-01	3.6e-02	2.0e-02	4.0e-01
2	Liver	gene expression	LOC134480367	0.15	0.15	2.2e-05	0.02	0.01	0.01	0.01	1.5e-03	8.6e-03	2.1e-02	7.2e-03
3	Adipose	alternative TSS	XR_010054782.1	0.55	0.2	7.2e-04	-0	0.01	0.01	0	3.9e-01	3.2e-02	1.3e-02	3.7e-01
4	Adipose	gene expression	LOC134480367	0.61	0.17	1.3e-05	0.02	0.04	0.03	0.01	1.9e-03	1.8e-05	3.2e-04	9.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.2	2.1	4.7	-1.4	2.2	1.3	0.6
Area under the delay curve	0.0	0.0	0.1	0.0	0.2	-0.0	-0.3
BMI with tail	2.4	8.4	13.9	3.7	-2.5	-3.7	0.2
BMI without tail	1.9	5.7	10.4	3.2	0.2	-3.2	1.3
Body weight	0.0	0.1	0.2	-0.1	0.4	0.1	0.2
Weight adjusted by age	5.6	8.5	16.2	-2.9	-0.9	2.9	-4.0
Bone surface	1.3	2.4	4.2	-2.0	0.1	2.0	-1.1
Bone volume	1.6	2.8	4.8	-2.2	1.2	2.2	-0.6
Breakpoint value in progressive ratio session	0.5	0.6	1.3	-0.7	1.2	0.7	0.2
Number of licking bursts	2.1	3.4	4.7	1.9	1.3	-1.9	2.2
Context. condit. distance diff. score	2.6	3.1	5.3	2.3	0.5	-2.3	1.3
Locomotion velocity, session 1	0.1	0.1	0.2	-0.1	0.3	0.1	-0.4
Locomotion distance, session 1	0.6	0.8	2.3	-0.3	-0.7	0.3	-1.5
Locomotion velocity, session 2	0.8	0.9	1.8	0.2	-1.3	-0.1	-1.3
Locomotion distance, session 2	0.7	0.9	1.8	-0.2	-1.4	0.2	-1.3
Locomotion velocity, session 3	0.5	0.6	0.9	0.9	-0.2	-0.9	-0.9
Locomotion distance, session 3	0.8	0.8	1.5	1.2	0.2	-1.2	-0.4
Stereotopy head waving bouts, day 3	0.6	0.7	1.0	1.0	-0.8	-1.0	0.2
Stereotopy head waving duration, day 3	0.2	0.3	0.4	0.6	0.1	-0.6	0.5
Locomotion velocity, session 7	1.0	1.1	1.8	-0.9	-1.3	0.9	-0.9
Locomotion distance, session 7	0.6	0.8	1.3	-0.5	-1.1	0.6	-1.1
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	0.1	0.7	-0.1	-0.7
Stereotopy head waving duration, day 7	0.2	0.2	0.7	-0.1	0.8	0.1	-0.3
Locomotion velocity, session 8	0.3	0.4	0.7	0.9	-0.0	-0.9	-0.1
Locomotion distance, session 8	0.9	1.3	2.3	1.5	-0.6	-1.5	-0.5
Degree of sensitization distance	1.2	1.3	2.3	-1.5	-0.8	1.5	0.0
Degree of sensitization stereotypy	0.4	0.4	1.0	0.1	0.7	-0.1	-1.0
Conditioned locomotion	0.1	0.1	0.3	-0.1	0.1	0.1	-0.5
Cocaine response after cond. corrected	1.5	1.8	5.2	-0.6	-1.1	0.7	-2.3
Cocaine response after cond. not corrected	2.2	2.6	4.0	-1.6	-1.0	1.7	-2.0
Cocaine response before conditioning	1.0	1.3	2.5	-1.6	-0.2	1.6	-0.0
Saline control response	0.0	0.0	0.2	0.1	0.4	-0.1	-0.1
Bone: connectivity density	0.2	0.2	0.3	-0.6	0.5	0.6	-0.3
Bone: cortical apparent density	2.9	4.0	6.6	2.1	-2.6	-2.0	-0.9
Bone: cortical area	1.1	1.6	2.9	-1.1	-1.1	1.1	-1.7
Bone: cortical porosity	0.5	0.5	1.0	-0.7	1.0	0.6	-0.3
Bone: cortical porosity	1.2	1.3	1.9	-1.4	1.0	1.3	-0.6
Bone: cortical thickness	0.6	1.1	2.1	0.9	-1.4	-0.8	-0.9
Bone: cortical thickness	0.8	0.9	1.2	-1.0	-0.6	1.0	-1.1
Bone: cortical tissue density	2.8	3.9	6.4	2.1	-2.5	-2.0	-0.9
Condit. Reinf. active minus inactive responses	3.4	3.8	4.9	-2.2	2.2	2.2	-1.0
Condit. Reinf. active-inactive response ratio	2.0	2.1	3.0	-1.6	1.7	1.5	-0.8
Condit. Reinf. active responses	3.1	3.9	6.0	-2.5	1.7	2.4	-0.9
Condit. Reinf. inactive responses	0.4	0.5	1.0	-1.0	-0.2	1.0	-0.4
Incentive salience index mean	2.8	3.5	4.6	-2.0	2.1	1.9	-1.2
Condit. Reinf. lever presses	0.5	0.6	2.1	-0.5	1.4	0.4	-0.2
Condit. Reinf. active minus inactive responses	2.7	3.5	5.0	-2.2	1.1	2.2	-1.7
Condit. Reinf. active-inactive response ratio	1.4	1.7	1.9	-1.3	1.4	1.3	-1.1
Condit. Reinf. active responses	1.4	2.0	3.3	-1.5	0.2	1.5	-1.8
Condit. Reinf. inactive responses	0.8	1.1	2.5	-0.7	-0.9	0.8	-1.6
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.5	0.1	0.5	-0.3
Condit. Reinf. lever reinforcers received	1.5	2.1	3.1	-1.6	0.0	1.6	-1.8
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.2	-0.3	0.2	-0.4
Conditioned reinforcement - inactives	2.2	3.3	7.2	-1.7	-0.6	1.7	-2.7
Conditioned locomotion	1.9	2.4	5.3	-0.1	-2.3	0.2	-2.1
Patch foraging indifference point 0 sec	0.9	1.7	2.3	1.5	-1.5	-1.4	0.5
Patch foraging indifference point AUC	0.3	0.4	1.2	-0.2	-0.7	0.2	1.1
Delay disc. indifference point, 0s delay	0.2	0.2	0.9	0.1	-0.1	-0.1	-0.9
Delay disc. indifference point, 16s delay	0.4	0.5	1.3	-0.5	1.1	0.5	0.3
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.1	-0.2	0.2	-0.2
Delay disc. indifference point, 24s delay	0.4	0.4	0.5	0.7	0.7	-0.7	0.6
Delay disc. indifference point, 4s delay	0.4	0.4	0.5	0.7	-0.7	-0.7	0.3
Delay disc. indifference point, 8s delay	0.4	0.4	0.6	-0.6	0.6	0.6	-0.8
Indifference point function ln k	0.3	0.5	0.8	0.8	0.3	-0.8	-0.9
Indifference point function log k	0.3	0.5	0.8	0.8	0.3	-0.8	-0.9
Patch foraging total patch changes 0 sec	0.8	1.6	2.5	1.4	-1.6	-1.3	0.1
Patch foraging total patch changes 12 sec	0.2	0.2	0.5	-0.1	-0.7	0.2	0.5
Patch foraging total patch changes 18 sec	0.8	1.2	2.2	0.9	-1.0	-0.9	1.5
Patch foraging total patch changes 24 sec	0.2	0.4	1.2	-0.1	-1.1	0.1	0.7
Patch foraging total patch changes 6 sec	2.0	3.0	3.2	1.7	-1.7	-1.7	1.8
Patch foraging time to switch 0 sec	0.2	0.3	0.7	-0.4	0.9	0.4	-0.6
Patch foraging water rate 0 sec	0.3	0.6	0.6	0.8	-0.7	-0.8	0.8
Patch foraging water rate 12 sec	0.1	0.3	0.5	0.6	0.2	-0.6	-0.7
Patch foraging water rate 18 sec	0.1	0.2	0.7	0.2	0.9	-0.3	-0.1
Patch foraging water rate 24 sec	0.2	0.3	1.0	-0.4	0.1	0.4	1.0
Patch foraging water rate 6 sec	0.4	0.6	1.0	1.0	-0.2	-1.0	-0.5
Seeking ratio, delayed vs. immediate footshock	2.4	2.9	5.2	-2.3	0.9	2.2	-0.8
Distance traveled before self-admin	2.8	3.7	6.7	-2.6	1.3	2.6	-0.2
Distance traveled after self-admin	1.2	1.4	2.7	-1.6	0.5	1.6	0.4
Extensor digitorum longus weight	4.1	16.1	41.3	1.0	-6.4	-0.8	-4.6
Bone: elastic displacement	1.5	1.7	2.8	1.2	1.7	-1.2	1.1
Bone: elastic work	1.0	1.3	1.7	-1.3	1.2	1.3	-0.6
Bone: endosteal estimation	3.0	6.5	12.4	-3.5	0.7	3.5	-0.9
Bone: endosteal perimeter	1.1	2.4	4.5	-2.1	0.5	2.1	-0.5
Epididymis fat weight	0.9	3.0	4.6	-2.1	-0.7	2.1	-1.6
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	0.3	-0.5	-0.3	-0.5
Delta time in open arm before/after self-admin	1.9	1.9	2.4	-1.6	1.1	1.5	-1.3
Diff in mean of infusions in LGA sessions	0.7	0.9	1.2	-1.1	0.8	1.0	0.8
Delay discount exponential model param	0.0	0.0	0.1	-0.2	-0.2	0.2	0.3
Extinction: sum of active levers before priming	0.4	0.5	1.5	-0.4	1.2	0.4	-0.0
Active lever presses in extinction session 6	0.5	0.5	1.4	-0.3	0.7	0.3	-1.2
Bone: final force	1.5	2.5	3.8	-1.9	-0.6	1.9	-1.4
Bone: final moment	0.9	1.4	2.2	-1.5	-0.6	1.5	-1.0
Food consumed during 24 hour testing period	0.4	0.5	0.7	-0.8	-0.4	0.8	0.8
Glucose	0.8	1.3	2.8	0.8	1.0	-0.9	1.7
Heart weight	0.1	0.1	0.1	-0.3	0.3	0.3	-0.4
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.2	-0.1	0.2	0.3
Intermittent access intake day 1-15 change	0.3	0.6	1.5	0.7	0.0	-0.7	1.2
Intermittent access intake escalation	0.9	1.8	3.8	1.3	0.0	-1.3	1.9
Intermittent access intake escalation 2	1.7	1.9	3.1	1.5	0.5	-1.5	1.8
Intermitt. access day 1 inactive lever presses	0.9	3.3	4.3	2.1	-0.6	-2.1	2.0
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.4	0.3	-0.6	-0.2	-0.4
Intermitt. access escalation Index	1.6	2.3	3.6	1.6	0.7	-1.6	1.9
Intermittent access day 1 total infusions	0.3	0.4	1.1	-0.3	1.0	0.2	0.7
Intermittent access day 15 total infusions	1.8	2.7	5.6	1.6	0.5	-1.6	2.4
Intermittent access terminal intake (last 3 days)	1.2	1.6	2.5	1.5	0.2	-1.6	1.3
Intermittent access total infusions	0.4	0.5	0.9	0.7	0.5	-0.7	0.9
Intermittent access day 1 locomotion	0.1	0.2	0.6	0.1	0.2	-0.1	0.8
Intermittent access day 15 total locomotion	0.2	0.4	0.9	0.2	-0.9	-0.2	1.0
Intermittent access total locomotion	0.6	0.8	1.0	1.0	-0.4	-1.0	1.0
Intermittent access standard deviation	0.1	0.2	0.3	-0.4	-0.5	0.4	-0.1
Left kidney weight	0.1	0.5	0.7	0.7	0.6	-0.7	0.9
Right kidney weight	0.1	0.3	0.8	0.4	-0.9	-0.4	0.5
Cocaine induced anxiety	1.1	1.6	2.2	1.1	-1.5	-1.0	-1.4
Post-drug Anxiety	1.2	1.3	1.8	1.2	-1.4	-1.1	0.7
Baseline Anxiety	0.9	1.1	1.4	-1.2	0.9	1.2	0.9
Tail length	1.3	5.1	13.5	-1.8	3.7	1.7	0.8
Length with tail	2.4	10.3	15.6	-4.0	3.2	3.9	-0.4
Length without tail	2.7	8.6	16.5	-4.0	0.5	4.1	-1.2
Times rat made contact with spout	1.5	1.7	2.3	1.2	1.2	-1.2	1.5
Lifetime Intake	0.3	0.4	0.5	0.7	-0.0	-0.7	0.7
Liver weight, left	0.8	1.3	2.3	-1.5	0.3	1.5	0.6
Liver weight, right	1.0	1.7	3.1	-1.8	0.7	1.8	-0.2
Locomotor activity	0.6	0.9	1.5	-1.0	-0.5	1.0	-1.2
Locomotor testing distance	0.2	0.3	0.7	-0.2	0.9	0.1	0.8
Locomotor testing rearing	1.2	2.3	4.2	1.4	1.0	-1.4	2.1
Locomotion in novel chamber	2.0	2.5	5.1	0.3	-2.2	-0.3	-2.2
Locomotion in novel chamber post-restriction	1.3	2.2	5.5	-0.7	-2.3	0.7	-1.5
Fecal boli incidents, locomotor time 1	1.1	1.6	6.3	0.2	0.3	-0.2	2.5
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.2
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.2	-0.4	-1.1	0.4	0.2
Bouts of movement, locomotor time 1	1.1	1.3	1.6	1.2	-1.3	-1.2	-0.7
Total resting periods, locomotor time 1	1.3	1.5	2.6	1.3	-1.6	-1.2	-0.4
Rest time, locomotor task time 1	1.6	2.0	4.0	1.4	0.1	-1.4	2.0
Distance moved, locomotor task time 1	0.4	0.6	0.8	-0.9	0.8	0.8	-0.5
Vertical activity count, locomotor time 1	0.1	0.2	0.5	-0.5	-0.0	0.5	-0.7
Time >=10cm from walls, locomotor time 2	0.7	1.0	1.4	-1.1	1.2	1.0	-0.6
Bouts of movement, locomotor time 2	1.3	2.1	4.4	1.1	-2.1	-1.0	-1.4
Total resting periods, locomotor time 2	1.2	2.1	4.2	1.1	-2.1	-1.1	-1.2
Rest time, locomotor task time 2	0.7	0.9	1.7	1.3	-0.4	-1.3	0.2
Distance moved, locomotor task time 2	0.8	0.9	1.5	-1.2	0.7	1.2	-0.5
Vertical activity count, locomotor time 2	0.1	0.1	0.3	-0.1	-0.0	0.0	-0.6
Light reinforcement 1	1.3	3.1	10.2	1.0	-3.2	-0.9	-0.5
Light reinforcement 2	0.5	0.8	1.7	0.9	-1.3	-0.8	-0.2
Bone: marrow area	2.8	6.0	11.5	-3.4	0.6	3.4	-0.9
Bone: maximum diameter	0.2	0.4	0.5	-0.6	-0.4	0.6	-0.7
Bone: maximum force	2.4	4.2	7.2	-2.7	-0.5	2.7	-1.5
Bone: maximum moment	1.5	2.7	4.6	-2.1	-0.5	2.1	-1.1
Mean time between licks in bursts	1.6	4.0	11.0	-0.1	-2.2	0.2	-3.3
Mean num. licks in bursts	0.4	0.6	0.7	-0.8	-0.6	0.8	-0.9
Cd content in liver	5.7	6.3	16.7	1.0	2.6	-1.1	4.1
Co content in liver	1.9	2.2	3.7	0.9	1.9	-0.9	1.8
Cu content in liver	0.4	0.5	1.8	-0.4	1.3	0.4	-0.0
Fe content in liver	1.0	1.2	4.6	-0.1	2.1	0.0	0.5
K content in liver	1.9	1.8	4.3	-0.3	-2.1	0.4	-1.7
Mg content in liver	0.3	0.3	0.7	0.1	-0.8	-0.1	-0.6
Mn content in liver	1.7	1.9	5.8	0.8	-0.7	-0.7	-2.4
Na content in liver	1.4	1.5	5.4	-0.6	-0.2	0.6	-2.3
Rb content in liver	3.1	3.6	7.2	-0.5	-2.7	0.6	-2.6
Se content in liver	0.5	0.6	1.9	-0.2	-0.6	0.2	-1.4
Sr content in liver	0.5	0.5	0.8	0.9	-0.1	-0.9	0.6
Zn content in liver	0.4	0.4	1.4	0.4	0.0	-0.4	1.2
Bone: minimum diameter	1.3	2.3	3.9	-1.9	-0.7	2.0	-1.1
Time in familiar zone, hab. session 1	1.6	1.6	3.3	1.2	0.3	-1.2	1.8
Time in novel zone, hab. session 1	1.7	1.7	3.6	-1.3	1.9	1.2	0.3
Total zone transitions, hab. session 1	1.3	1.9	3.1	-1.7	-0.8	1.8	-0.8
Total locomotion distance, hab. session 1	3.1	4.3	7.4	-2.7	-0.9	2.7	-1.5
Locomotion velocity, hab. session 1	2.5	3.5	4.8	-2.1	-1.5	2.2	-1.6
Time in familiar zone, hab. session 2	0.3	0.4	1.0	0.4	0.2	-0.4	1.0
Time in novel zone, hab. session 2	0.1	0.1	0.5	-0.1	0.7	0.1	0.1
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.4	0.1	0.4	-0.3
Total locomotion distance, hab. session 2	1.5	1.9	3.3	-1.8	-0.0	1.8	-1.0
Locomotion velocity, hab. session 2	1.2	1.7	2.7	-1.6	-0.3	1.7	-1.0
Novel to familiar place preference ratio	3.6	3.9	7.2	-1.9	1.2	1.9	-2.7
Novelty place preference	2.5	2.7	5.2	-1.4	1.2	1.4	-2.3
Time in novel zone, NPP test	2.3	2.4	4.3	-1.4	1.4	1.3	-2.1
Total zone transitions, NPP test	0.1	0.1	0.4	0.3	-0.6	-0.3	-0.1
Total locomotion distance, NPP test	0.2	0.3	0.5	-0.7	-0.3	0.7	-0.5
Locomotion velocity, NPP test	0.3	0.4	0.6	-0.5	-0.7	0.5	-0.8
Intraocular pressure	0.7	0.9	2.9	0.6	0.3	-0.6	1.7
Delta distance traveled before/after self-admin	0.3	0.3	0.3	0.6	-0.6	-0.6	0.4
Delta ambulatory time before/after self-admin	0.3	0.4	0.7	0.6	-0.9	-0.6	-0.2
Parametrial fat weight	0.9	2.2	5.4	1.3	-0.5	-1.2	2.3
Pavlov. Cond. lever latency	0.8	1.0	3.5	0.6	-1.9	-0.5	0.1
Pavlov. Cond. magazine entry latency	1.7	2.2	3.8	-1.6	1.9	1.5	0.5
Pavlov. Cond. change in total contacts	2.0	2.1	2.7	-1.6	1.6	1.5	-0.9
Pavlov. Cond. index score	1.3	1.7	4.8	-0.9	2.2	0.8	0.5
Pavlov. Cond. latency score	1.4	1.8	4.6	-1.1	2.1	1.1	0.2
Pavlov. Cond. lever contacts	0.8	1.0	3.6	-0.4	1.9	0.4	0.0
Pavlov. Cond. magazine entry number	2.2	2.8	5.6	1.7	-2.4	-1.6	-0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.6	-0.2	-0.2	0.2	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	3.9	-1.0	2.0	0.9	0.3
Pavlov. Cond. response bias	1.6	2.0	5.1	-1.2	2.3	1.2	0.1
Pavlov. Cond. lever latency	0.4	0.6	0.9	1.0	-0.4	-0.9	0.6
Pavlov. Cond. magazine entry latency	0.8	1.0	2.0	-0.8	0.8	0.8	1.4
Pavlov. Cond. change in total contacts	0.7	1.0	1.4	-1.2	1.2	1.2	0.1
Pavlov. Cond. index score	0.8	1.0	1.7	-1.3	0.7	1.3	0.5
Pavlov. Cond. latency score	0.9	1.2	2.1	-1.4	0.5	1.4	0.6
Pavlov. Cond. lever contacts	0.5	0.7	1.1	-1.0	0.8	1.0	-0.4
Pavlov. Cond. magazine entry number	0.9	1.1	2.7	0.7	-1.0	-0.6	-1.6
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.1	0.5	-1.1	-0.5	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.2	-1.1	0.5	1.1	0.6
Pavlov. Cond. response bias	1.1	1.6	2.4	-1.5	0.9	1.5	-0.9
Time in closed arm before self-admin	1.9	2.5	5.3	-1.2	1.4	1.2	2.3
Time in closed arm after self-admin	0.3	0.3	0.9	-0.4	0.4	0.4	0.9
Time in open arm before self-admin	0.9	1.0	1.4	1.2	-0.9	-1.2	-0.7
Time in open arm after self-admin	1.7	1.8	2.6	-1.6	1.0	1.6	-1.1
Bone: periosteal estimation	2.3	4.7	8.7	-2.9	0.1	3.0	-1.3
Bone: periosteal perimeter	0.8	1.3	2.3	-1.5	0.4	1.5	-0.7
Bone: post-yield work	0.9	1.3	2.6	-1.6	0.1	1.6	-0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.3	-0.2	-0.3	-0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.0	-0.2	0.0	-0.1
Progressive ratio test 1 inactive lever presses	0.7	1.0	2.0	1.0	-1.4	-1.0	-0.3
Progressive ratio test 2 active lever presses	0.3	0.4	1.5	0.2	-0.0	-0.2	-1.2
Progressive ratio test 2 breakpoint	0.3	0.3	0.9	0.5	0.0	-0.5	-1.0
Progressive ratio test 2 inactive lever presses	0.2	0.4	0.7	0.8	-0.0	-0.8	0.4
Incentive Sensitization - Responses	0.2	0.2	0.4	-0.4	0.6	0.3	-0.6
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	-0.1	0.5	0.0	-0.4
Sum of active levers in priming session hrs 5-6	2.5	2.3	3.9	-2.0	1.1	1.9	-0.7
Progressive ratio	0.2	0.3	0.8	0.0	-0.9	0.0	-0.5
Food seeking constrained by brief footshock	0.2	0.2	0.6	-0.0	-0.8	0.1	0.6
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.2
Retroperitoneal fat weight	0.5	2.1	4.7	-0.6	-1.7	0.6	-2.2
Reaction time number correct	0.7	1.3	3.5	0.4	-1.2	-0.3	-1.9
Reaction time mean minus median	0.4	0.9	2.2	-0.7	1.5	0.7	0.6
Reaction time mean minus median AUC	0.3	0.8	2.0	-0.4	1.4	0.4	0.9
Reaction time num false alarms	2.3	3.3	6.0	1.7	-2.5	-1.7	1.1
Reaction time num false alarms AUC	1.9	2.9	8.1	1.4	-2.8	-1.3	0.3
Reaction time trials correct on left	0.7	1.3	3.5	0.4	-1.2	-0.3	-1.9
Reaction time trials on left	0.6	1.2	3.2	0.4	-1.2	-0.3	-1.8
Reaction time mean	2.7	4.3	6.4	-2.3	2.5	2.2	-1.0
Reaction time mean AUC	2.5	4.0	5.5	-2.1	2.4	2.0	-1.2
Median of all reaction times	3.3	4.7	6.5	-2.3	2.6	2.2	-1.4
Reaction time omissions	1.1	1.6	4.4	0.5	1.3	-0.5	2.1
Reaction time false alarm rate	1.2	1.7	3.5	1.0	-1.9	-1.0	1.2
Reaction time premature initiation rate	0.1	0.2	0.6	-0.2	0.4	0.1	0.7
Reaction time premature initiations	0.1	0.1	0.5	-0.2	-0.2	0.2	-0.7
Std. dev. reaction times	1.7	3.1	6.1	-1.8	2.5	1.7	0.3
Reaction time trials completed	0.6	1.2	3.2	0.4	-1.2	-0.3	-1.8
Reaction time trials AUC	0.6	1.2	3.0	0.5	-1.1	-0.4	-1.7
Run reversals in cocaine runway, females	2.2	2.2	4.7	-1.3	-1.0	1.3	-2.2
Run reversals in cocaine runway, males	0.6	0.6	1.2	0.8	-1.1	-0.8	-0.0
Latency to leave start box in cocaine runway	4.0	4.6	6.9	2.6	-2.2	-2.5	0.2
Latency to leave start box in cocaine runway, F	4.2	4.8	7.8	2.8	-1.4	-2.8	1.4
Latency to leave start box in cocaine runway, M	1.9	1.8	3.8	0.6	-2.0	-0.5	-1.7
Std. dev. time between licks in bursts	2.9	3.9	5.5	2.1	-2.3	-2.0	-1.4
Total sessions with >9 infusions	1.1	1.3	3.5	0.1	-1.9	-0.0	-1.3
Short access day 1 total inactive lever presses	1.7	2.2	4.7	0.6	-1.9	-0.5	2.2
Short access day 10 total inactive lever presses	0.3	0.7	2.5	0.2	-0.5	-0.2	1.6
Short access day 1 total infusions	1.7	2.3	4.7	-0.5	-2.0	0.6	-2.2
Short access day 10 total infusions	1.3	1.6	3.1	1.7	0.2	-1.8	-0.4
Short access total infusions	0.3	0.3	0.4	0.5	-0.6	-0.5	-0.6
Short access day 1 locomotion	2.2	2.7	4.7	-0.8	-2.2	0.9	-2.2
Short access day 10 total locomotion	0.4	0.7	1.8	0.6	-0.4	-0.6	1.4
Short access total locomotion	0.8	0.9	3.2	0.3	-1.8	-0.3	-0.6
One hour access (0.3 mA shock)	0.2	0.2	0.4	-0.4	0.7	0.3	0.3
Compulsive drug intake	0.9	1.1	1.2	1.1	-1.1	-1.0	0.9
One hour access (shock baseline)	0.4	0.6	1.2	-0.4	1.0	0.3	1.1
Social response proportion	0.3	0.4	0.9	-0.3	0.7	0.3	-1.0
Social responses	0.5	0.6	1.0	1.0	-0.0	-1.0	0.7
Social time	0.4	0.6	2.1	0.3	1.5	-0.3	0.3
Soleus weight	0.5	1.4	4.7	0.2	-2.2	-0.1	-0.8
Bone: stiffness	2.4	3.9	6.7	-2.5	-0.9	2.6	-1.3
Tibialis anterior weight	2.0	6.9	17.1	1.6	-4.1	-1.5	-2.5
Time to tail flick, vehicle, before self-admin	0.9	0.9	2.9	0.6	0.3	-0.7	1.7
Time to tail flick, vehicle, after self-admin	0.7	1.0	2.8	-0.4	1.0	0.3	1.7
Time to tail flick, test, before self-admin	1.1	1.2	3.6	0.8	-1.9	-0.7	0.0
Time to tail flick, test, after self-admin	1.2	1.3	3.9	0.8	-2.0	-0.7	-0.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	-0.5	0.4	0.5	-0.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.1	0.5	-0.1	0.4
Tibia length	4.2	11.6	21.8	-4.7	1.0	4.7	-1.4
Ambulatory time before self-admin	2.2	3.3	5.4	-2.3	1.6	2.3	0.2
Ambulatory time after self-admin	0.6	0.6	1.0	-1.0	0.4	1.0	0.7
Bone: tissue strength	0.2	0.2	0.3	0.6	0.2	-0.5	0.6
Total heroin consumption	0.4	0.5	1.2	-0.0	1.1	-0.0	0.8
Bone: trabecular number	0.5	0.9	2.0	-0.9	1.4	0.8	0.3
Bone: trabecular spacing	0.5	0.7	1.7	-0.2	-1.3	0.2	-0.9
Bone: trabecular thickness	2.8	3.5	9.2	-0.9	3.0	0.8	1.8
Bone: trabecular tissue density	0.7	1.0	1.4	-1.2	0.0	1.2	-1.1
Water consumed over 24 hours	1.4	1.9	4.2	1.3	0.1	-1.3	2.0
Number of responses in last shaping day	0.5	0.6	1.0	-1.0	-0.1	1.0	-0.6