Hub : Genes

LOC134479949

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression LOC134479949 0.16 0.09 0.0e+00 0.22 0.22 0.22 0.23 8.4e-20 2.2e-20 1.3e-20 4.2e-21
2 pVTA intron excision ratio chr7_116631499_116632673 0.07 0.05 2.0e-06 0.05 0.07 0.06 0.06 1.3e-04 3.5e-06 1.5e-05 3.3e-05
3 LHb mRNA stability LOC134479949 0.14 0.11 8.1e-03 0.05 0.04 0.02 0.04 2.2e-02 3.5e-02 1.1e-01 4.4e-02
4 pVTA intron excision ratio chr7_116632847_116639382 0.06 0.04 7.5e-06 0.05 0.06 0.05 0.04 1.1e-04 3.3e-05 4.0e-05 2.3e-04
5 PL gene expression LOC134479949 0.07 0.04 1.1e-10 0.09 0.09 0.09 0.09 4.2e-10 2.2e-10 4.8e-10 5.4e-10
6 pVTA gene expression LOC134479949 0.07 0.05 3.4e-07 0.06 0.07 0.07 0.07 5.7e-06 2.6e-06 4.0e-06 5.0e-06
7 NAcc intron excision ratio chr7_116632847_116639382 0.03 0.02 3.2e-05 0.02 0.03 0.02 0.02 3.0e-04 8.7e-05 2.5e-04 2.6e-04
8 Brain mRNA stability LOC134479949 0.04 0.03 5.6e-05 0.04 0.04 0.04 0.04 1.2e-04 4.3e-05 7.6e-05 5.8e-05
9 BLA gene expression LOC134479949 0.14 0.11 7.1e-05 0.07 0.07 0.06 0.06 2.2e-04 1.7e-04 2.5e-04 5.5e-04
10 OFC mRNA stability LOC134479949 0.2 0.15 1.0e-03 0.1 0.09 0.07 0.08 3.0e-03 4.5e-03 8.5e-03 6.2e-03
11 PL intron excision ratio chr7_116631499_116639382 0.02 0.02 5.5e-03 0.02 0.01 0.01 0.02 5.1e-03 1.5e-02 1.9e-02 4.6e-03
12 NAcc gene expression LOC134479949 0.27 0.15 0.0e+00 0.11 0.11 0.11 0.12 1.9e-16 1.6e-16 3.4e-16 5.0e-17
13 RMTg gene expression LOC134479949 0.71 0.2 2.4e-07 0.23 0.25 0.26 0.24 9.1e-07 2.8e-07 1.1e-07 5.8e-07
14 Adipose gene expression LOC134479949 0.27 0.18 3.8e-11 0.09 0.07 0.09 0.09 7.8e-10 3.2e-08 9.8e-10 9.6e-10
15 IC gene expression LOC134479949 0.06 0.05 9.3e-03 0.03 0.02 0.03 0.02 2.6e-02 4.7e-02 2.9e-02 6.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.40.71.30.90.81.1-0.80.80.8-0.8-0.80.70.91.00.7-1.2-0.7-0.8
Area under the delay curve1.21.81.91.41.41.1-1.41.31.4-1.3-1.41.41.31.21.3-1.3-1.4-1.4
BMI with tail1.44.96.9-2.4-2.2-1.72.3-2.2-2.32.22.3-2.2-1.9-1.8-2.42.02.42.6
BMI without tail0.31.52.4-1.5-1.1-0.91.2-1.2-1.21.01.1-1.0-1.2-1.1-1.51.31.51.2
Body weight1.67.08.6-2.9-2.5-2.72.5-2.6-2.52.52.5-2.5-2.7-2.7-2.92.92.92.5
Weight adjusted by age0.00.10.3-0.3-0.3-0.30.4-0.3-0.40.30.3-0.3-0.4-0.4-0.30.30.30.5
Bone surface0.00.10.10.30.20.4-0.30.30.2-0.2-0.30.00.10.10.2-0.2-0.2-0.3
Bone volume0.00.10.20.30.20.4-0.30.30.3-0.2-0.30.10.20.20.2-0.3-0.3-0.3
Breakpoint value in progressive ratio session0.10.30.8-0.6-0.3-0.50.3-0.4-0.30.30.3-0.3-0.8-0.6-0.70.90.70.2
Number of licking bursts0.00.10.30.40.40.4-0.40.40.4-0.4-0.40.50.00.10.4-0.2-0.3-0.6
Context. condit. distance diff. score5.56.67.6-2.5-2.7-2.72.7-2.7-2.72.72.7-2.7-2.5-2.0-2.52.02.52.6
Locomotion velocity, session 10.80.91.7-0.7-0.9-0.70.9-0.9-0.91.00.9-1.1-1.3-1.2-0.81.00.80.8
Locomotion distance, session 10.40.51.50.90.61.2-0.50.70.5-0.6-0.50.50.50.70.7-0.7-0.7-0.7
Locomotion velocity, session 20.91.11.5-0.9-1.1-0.71.1-1.0-1.11.11.1-1.2-1.0-1.0-1.10.81.11.2
Locomotion distance, session 21.21.63.01.41.21.7-1.21.31.2-1.3-1.21.21.21.11.2-1.2-1.2-1.3
Locomotion velocity, session 30.50.61.0-0.6-0.8-0.30.9-0.7-0.80.90.9-1.0-0.5-0.7-0.90.30.90.9
Locomotion distance, session 31.21.42.51.31.01.3-1.01.11.0-1.0-1.01.01.51.61.0-1.6-1.0-0.8
Stereotopy head waving bouts, day 30.81.01.7-1.0-1.0-0.80.9-0.9-0.90.90.9-1.1-1.1-1.3-1.01.00.91.0
Stereotopy head waving duration, day 35.06.28.0-2.6-2.5-2.22.4-2.4-2.42.42.4-2.6-2.7-2.8-2.52.42.42.4
Locomotion velocity, session 70.00.00.1-0.0-0.10.30.10.0-0.10.10.1-0.2-0.00.1-0.1-0.20.10.2
Locomotion distance, session 71.01.32.11.21.11.5-1.01.21.1-1.1-1.01.01.31.41.1-1.3-1.0-0.9
Stereotopy head waving bouts, day 74.24.86.5-2.0-2.3-2.12.2-2.2-2.22.22.2-2.4-2.2-2.6-2.12.02.12.1
Stereotopy head waving duration, day 73.44.35.4-2.0-2.1-2.02.1-2.1-2.02.12.0-2.2-2.1-2.3-2.11.92.02.0
Locomotion velocity, session 86.98.39.5-2.7-3.0-2.83.0-2.9-3.02.93.0-2.9-3.1-2.9-2.92.72.92.6
Locomotion distance, session 81.11.62.3-1.1-1.4-1.11.4-1.3-1.41.41.4-1.4-1.5-1.1-1.21.01.21.1
Degree of sensitization distance0.91.01.4-1.1-0.9-1.00.9-1.0-0.91.00.9-1.0-1.2-1.1-0.91.10.90.9
Degree of sensitization stereotypy3.74.24.9-1.9-2.1-2.02.1-2.0-2.12.12.1-2.1-2.0-2.2-2.01.82.02.0
Conditioned locomotion0.10.10.2-0.4-0.2-0.40.2-0.3-0.20.20.2-0.2-0.5-0.3-0.20.40.20.1
Cocaine response after cond. corrected0.00.00.00.1-0.2-0.10.2-0.1-0.20.20.2-0.2-0.10.00.0-0.1-0.2-0.2
Cocaine response after cond. not corrected0.00.00.10.1-0.2-0.20.2-0.2-0.20.20.2-0.2-0.1-0.10.0-0.2-0.1-0.1
Cocaine response before conditioning0.10.10.10.30.30.2-0.30.30.3-0.3-0.30.30.20.10.3-0.1-0.3-0.2
Saline control response0.30.41.3-0.6-0.6-0.60.5-0.6-0.60.50.5-0.6-0.9-0.8-0.71.20.60.3
Bone: connectivity density0.10.20.50.40.40.6-0.40.40.4-0.4-0.40.30.40.60.1-0.7-0.2-0.2
Bone: cortical apparent density1.72.73.81.71.61.4-1.61.61.6-1.6-1.61.62.01.71.6-1.4-1.6-1.6
Bone: cortical area1.42.33.1-1.5-1.5-1.71.5-1.5-1.51.51.4-1.5-1.6-1.8-1.51.71.41.2
Bone: cortical porosity0.20.20.7-0.3-0.4-0.40.4-0.4-0.40.40.4-0.4-0.4-0.4-0.40.10.50.8
Bone: cortical porosity1.31.42.1-1.1-1.1-1.31.1-1.1-1.11.21.1-1.2-1.2-1.3-1.11.01.21.4
Bone: cortical thickness0.10.10.5-0.3-0.0-0.6-0.0-0.2-0.00.0-0.00.1-0.4-0.4-0.30.70.3-0.0
Bone: cortical thickness0.40.51.0-0.7-0.6-1.00.6-0.7-0.60.60.6-0.4-1.0-0.6-0.60.90.60.6
Bone: cortical tissue density1.52.43.51.61.51.3-1.51.51.5-1.5-1.51.51.91.61.6-1.4-1.6-1.5
Condit. Reinf. active minus inactive responses1.41.62.81.31.30.9-1.31.31.4-1.3-1.31.21.70.61.3-1.0-1.3-1.4
Condit. Reinf. active-inactive response ratio0.00.10.4-0.2-0.1-0.30.0-0.1-0.00.10.0-0.20.2-0.7-0.10.20.10.0
Condit. Reinf. active responses3.64.66.02.32.11.8-2.22.22.2-2.1-2.22.12.51.72.2-2.0-2.3-2.3
Condit. Reinf. inactive responses3.64.75.32.32.22.3-2.12.22.1-2.2-2.12.22.12.32.1-2.0-2.1-2.1
Incentive salience index mean2.22.94.11.81.81.4-1.81.81.8-1.7-1.81.62.01.11.7-1.4-1.7-1.8
Condit. Reinf. lever presses2.23.33.81.91.91.7-1.91.91.9-1.8-1.91.71.91.41.9-1.5-1.9-1.9
Condit. Reinf. active minus inactive responses0.10.10.5-0.2-0.1-0.30.1-0.1-0.10.10.1-0.2-0.6-0.7-0.10.50.2-0.1
Condit. Reinf. active-inactive response ratio0.10.10.6-0.2-0.2-0.30.1-0.2-0.20.20.1-0.3-0.7-0.8-0.10.50.1-0.1
Condit. Reinf. active responses0.81.12.7-0.9-0.9-1.10.9-0.9-0.90.90.9-1.0-1.4-1.6-0.81.30.90.8
Condit. Reinf. inactive responses0.71.11.6-1.0-1.0-1.01.0-1.0-1.01.01.0-1.1-1.2-1.3-0.91.11.01.1
Condit. Reinf. lever presses0.10.20.50.60.40.3-0.40.40.4-0.4-0.40.30.2-0.10.7-0.4-0.7-0.7
Condit. Reinf. lever reinforcers received0.20.31.2-0.3-0.4-0.60.3-0.4-0.30.40.3-0.5-0.9-1.1-0.30.80.30.2
Conditioned reinforcement - actives0.00.10.30.30.1-0.5-0.20.20.2-0.1-0.20.10.50.20.2-0.6-0.3-0.4
Conditioned reinforcement - inactives0.00.10.2-0.3-0.4-0.40.4-0.3-0.30.30.3-0.3-0.1-0.3-0.40.00.40.2
Conditioned locomotion0.30.40.7-0.6-0.7-0.90.6-0.6-0.60.70.6-0.7-0.4-0.9-0.60.30.60.4
Patch foraging indifference point 0 sec0.10.10.30.20.40.3-0.40.40.4-0.4-0.40.40.40.50.2-0.5-0.2-0.5
Patch foraging indifference point AUC0.20.50.80.80.70.6-0.70.70.7-0.6-0.70.60.90.90.6-0.8-0.8-0.6
Delay disc. indifference point, 0s delay0.30.30.5-0.6-0.6-0.60.6-0.6-0.60.60.6-0.6-0.5-0.4-0.70.30.60.7
Delay disc. indifference point, 16s delay2.33.23.91.91.81.4-1.91.81.9-1.8-1.91.81.71.41.8-1.7-1.9-2.0
Delay disc. indifference point, 2s delay0.50.60.80.70.80.8-0.70.80.7-0.8-0.70.80.70.90.5-0.9-0.7-0.6
Delay disc. indifference point, 24s delay0.40.70.80.80.90.7-0.90.80.9-0.8-0.90.80.80.70.8-0.7-0.9-0.9
Delay disc. indifference point, 4s delay0.10.10.40.40.30.4-0.30.30.3-0.3-0.30.30.40.30.4-0.6-0.5-0.4
Delay disc. indifference point, 8s delay1.72.93.11.81.71.5-1.81.71.7-1.7-1.71.71.81.71.7-1.6-1.7-1.7
Indifference point function ln k0.61.92.5-1.6-1.3-1.11.3-1.3-1.31.21.3-1.2-1.5-1.4-1.51.61.61.3
Indifference point function log k0.61.92.5-1.6-1.3-1.11.3-1.3-1.31.21.3-1.2-1.5-1.4-1.51.61.61.3
Patch foraging total patch changes 0 sec0.10.20.40.30.50.5-0.50.50.5-0.5-0.50.50.50.70.3-0.6-0.3-0.6
Patch foraging total patch changes 12 sec0.00.00.2-0.1-0.2-0.10.2-0.1-0.20.30.2-0.4-0.0-0.1-0.2-0.00.10.0
Patch foraging total patch changes 18 sec0.00.00.10.00.30.1-0.30.20.3-0.3-0.30.2-0.0-0.00.00.1-0.0-0.1
Patch foraging total patch changes 24 sec0.10.30.90.50.50.5-0.50.50.5-0.4-0.50.40.70.90.3-0.8-0.4-0.4
Patch foraging total patch changes 6 sec0.00.00.1-0.0-0.0-0.3-0.00.00.00.0-0.0-0.0-0.00.1-0.1-0.10.1-0.1
Patch foraging time to switch 0 sec0.10.50.90.90.70.7-0.70.70.7-0.6-0.70.50.50.41.0-0.8-0.9-0.8
Patch foraging water rate 0 sec0.31.01.5-1.2-1.0-1.01.1-1.1-1.11.01.1-0.9-0.8-0.7-1.20.61.10.9
Patch foraging water rate 12 sec0.10.61.0-0.9-0.70.10.8-0.7-0.80.70.8-0.7-0.7-0.7-1.00.41.01.0
Patch foraging water rate 18 sec0.00.00.50.10.00.2-0.00.10.1-0.1-0.10.00.20.20.2-0.2-0.2-0.7
Patch foraging water rate 24 sec2.13.04.3-2.0-1.6-1.41.6-1.6-1.61.51.6-1.6-1.9-2.0-1.92.11.81.4
Patch foraging water rate 6 sec0.20.20.60.30.50.8-0.50.50.5-0.5-0.50.40.60.40.3-0.3-0.3-0.6
Seeking ratio, delayed vs. immediate footshock2.33.35.21.71.82.3-1.81.91.8-1.9-1.81.81.62.11.5-2.0-1.4-1.7
Distance traveled before self-admin0.20.40.70.60.60.8-0.60.60.6-0.6-0.60.60.50.60.6-0.7-0.60.2
Distance traveled after self-admin0.00.00.2-0.2-0.0-0.10.0-0.1-0.00.00.00.0-0.30.0-0.20.30.20.4
Extensor digitorum longus weight0.00.10.2-0.2-0.2-0.10.3-0.2-0.30.20.3-0.10.40.2-0.2-0.30.30.5
Bone: elastic displacement1.31.71.9-1.3-1.3-1.31.3-1.3-1.31.31.3-1.3-1.3-1.1-1.31.01.31.4
Bone: elastic work4.66.06.7-2.4-2.6-2.42.6-2.5-2.52.62.5-2.6-2.4-2.3-2.32.02.32.4
Bone: endosteal estimation1.64.06.1-1.7-2.2-1.62.3-2.0-2.22.32.2-2.5-1.7-2.0-1.71.31.72.0
Bone: endosteal perimeter1.43.54.9-1.8-2.0-1.72.0-1.9-2.02.12.0-2.2-1.8-2.1-1.61.61.61.7
Epididymis fat weight0.63.14.0-1.9-1.7-2.01.6-1.7-1.61.71.6-1.8-1.7-1.9-1.92.01.91.5
Delta time in closed arm before/after self-admin0.30.30.70.60.50.1-0.50.50.5-0.4-0.50.50.80.40.7-0.9-0.6-0.4
Delta time in open arm before/after self-admin0.40.51.2-0.6-0.8-0.20.9-0.7-0.90.80.9-0.8-0.5-0.5-0.50.30.51.1
Diff in mean of infusions in LGA sessions0.00.10.4-0.1-0.2-0.50.1-0.2-0.10.20.1-0.1-0.2-0.6-0.20.40.3-0.3
Delay discount exponential model param1.31.71.9-1.3-1.3-1.11.4-1.3-1.41.31.4-1.3-1.3-1.2-1.31.31.31.4
Extinction: sum of active levers before priming0.10.20.8-0.2-0.4-0.90.4-0.4-0.40.50.4-0.5-0.3-0.4-0.10.20.20.3
Active lever presses in extinction session 60.70.70.9-0.8-0.8-0.60.8-0.8-0.80.80.8-0.8-1.0-0.6-0.91.00.90.7
Bone: final force0.71.21.5-1.0-1.2-1.21.1-1.1-1.11.21.1-1.2-1.0-1.2-1.01.10.90.8
Bone: final moment1.21.92.2-1.3-1.5-1.51.5-1.4-1.51.51.4-1.5-1.3-1.5-1.31.31.21.1
Food consumed during 24 hour testing period1.53.03.5-1.9-1.8-1.61.8-1.8-1.81.81.8-1.8-1.3-1.7-1.71.91.71.5
Glucose0.30.50.60.50.80.7-0.80.70.7-0.8-0.70.80.70.60.4-0.8-0.4-0.5
Heart weight9.415.119.2-4.0-3.9-4.43.9-4.0-3.93.93.9-3.8-3.6-3.9-3.74.03.73.8
Delay discount hyperbolic model param1.11.41.5-1.2-1.2-1.01.2-1.2-1.21.21.2-1.2-1.2-1.1-1.11.21.21.2
Intermittent access intake day 1-15 change0.20.81.10.81.00.8-1.01.01.0-1.0-1.01.01.00.50.9-1.1-0.8-0.7
Intermittent access intake escalation0.21.11.41.01.10.8-1.11.11.1-1.1-1.11.11.10.71.0-1.2-1.0-0.8
Intermittent access intake escalation 20.91.62.11.31.31.1-1.31.31.3-1.3-1.31.31.41.11.2-1.4-1.2-1.0
Intermitt. access day 1 inactive lever presses0.00.40.8-0.5-0.6-0.90.6-0.6-0.60.60.6-0.6-0.5-0.3-0.70.70.70.6
Intermitt. access day 15 inactive lever presses0.00.00.4-0.1-0.2-0.60.2-0.2-0.10.20.1-0.2-0.2-0.10.1-0.0-0.2-0.2
Intermitt. access escalation Index0.10.40.60.50.70.6-0.70.60.7-0.7-0.70.70.60.80.7-0.4-0.7-0.5
Intermittent access day 1 total infusions0.20.50.6-0.7-0.8-0.60.8-0.7-0.80.80.8-0.8-0.6-0.6-0.60.30.70.7
Intermittent access day 15 total infusions0.10.30.80.40.40.5-0.40.50.4-0.4-0.40.40.60.40.5-0.9-0.4-0.3
Intermittent access terminal intake (last 3 days)0.30.52.20.70.50.6-0.50.60.5-0.5-0.50.41.00.80.6-1.5-0.5-0.4
Intermittent access total infusions0.00.10.5-0.0-0.20.20.2-0.1-0.20.20.2-0.20.30.00.1-0.7-0.00.2
Intermittent access day 1 locomotion0.00.00.10.00.10.1-0.10.10.1-0.1-0.10.10.2-0.00.0-0.20.0-0.3
Intermittent access day 15 total locomotion0.00.10.3-0.2-0.30.10.3-0.2-0.30.30.3-0.3-0.1-0.6-0.1-0.20.20.3
Intermittent access total locomotion0.10.10.2-0.2-0.30.20.3-0.2-0.30.30.3-0.30.1-0.3-0.1-0.40.20.3
Intermittent access standard deviation0.00.00.3-0.0-0.1-0.10.1-0.0-0.10.10.1-0.10.1-0.4-0.1-0.50.1-0.0
Left kidney weight8.669.275.1-8.4-8.4-8.58.3-8.4-8.38.38.3-8.4-8.6-8.7-8.28.38.17.7
Right kidney weight10.473.077.9-8.7-8.6-8.58.6-8.6-8.68.68.5-8.6-8.8-8.8-8.48.48.38.1
Cocaine induced anxiety0.71.92.9-1.4-1.4-1.11.4-1.4-1.41.41.4-1.4-1.5-1.7-1.31.51.31.2
Post-drug Anxiety0.20.20.5-0.6-0.3-0.20.3-0.4-0.40.30.4-0.3-0.5-0.7-0.70.60.60.0
Baseline Anxiety1.42.32.71.41.61.5-1.61.61.6-1.6-1.61.61.51.61.2-1.3-1.1-1.6
Tail length0.00.20.70.20.60.3-0.60.50.6-0.7-0.60.70.20.10.1-0.0-0.2-0.8
Length with tail0.31.52.5-1.4-1.1-1.61.1-1.2-1.11.11.1-1.1-1.2-1.4-1.31.41.30.7
Length without tail0.63.45.4-1.8-1.8-2.31.7-1.8-1.71.91.7-2.0-1.6-1.9-1.81.91.81.6
Times rat made contact with spout1.71.92.7-1.6-1.3-1.01.4-1.4-1.41.31.4-1.2-1.0-1.3-1.61.61.61.5
Lifetime Intake0.20.20.4-0.4-0.5-0.30.6-0.4-0.50.50.5-0.6-0.2-0.4-0.2-0.30.30.6
Liver weight, left0.10.21.1-0.5-0.2-0.50.2-0.3-0.20.20.2-0.2-0.6-0.7-0.31.00.2-0.1
Liver weight, right0.71.22.3-1.1-1.0-1.50.9-1.0-0.90.90.9-0.9-1.2-1.4-0.91.51.00.5
Locomotor activity2.94.57.1-2.0-2.1-2.32.1-2.1-2.02.12.0-2.2-2.2-2.7-2.02.02.01.8
Locomotor testing distance0.10.20.40.50.30.4-0.30.30.3-0.3-0.30.20.4-0.10.5-0.5-0.6-0.6
Locomotor testing rearing0.10.51.0-0.6-0.8-0.90.8-0.8-0.80.80.8-0.8-0.8-1.0-0.40.60.40.5
Locomotion in novel chamber0.10.20.30.50.50.0-0.50.40.5-0.5-0.50.50.40.50.2-0.3-0.2-0.1
Locomotion in novel chamber post-restriction0.51.42.21.21.11.5-1.11.21.1-1.1-1.11.11.11.31.2-1.3-1.2-1.2
Fecal boli incidents, locomotor time 10.00.10.20.40.20.4-0.20.20.2-0.2-0.20.10.10.30.4-0.4-0.4-0.3
Change in fecal boli incidents, locomotor task1.01.12.0-1.1-1.0-1.00.9-1.0-0.91.00.9-0.9-1.0-1.2-1.11.41.10.8
Time >=10cm from walls, locomotor time 10.00.00.10.2-0.1-0.00.1-0.0-0.10.20.1-0.30.10.00.3-0.1-0.1-0.2
Bouts of movement, locomotor time 10.10.10.10.20.30.3-0.30.30.3-0.3-0.30.30.10.00.3-0.4-0.4-0.3
Total resting periods, locomotor time 10.20.30.40.40.50.6-0.50.50.5-0.5-0.50.50.40.30.5-0.6-0.6-0.6
Rest time, locomotor task time 10.00.00.1-0.2-0.10.10.1-0.1-0.10.10.1-0.1-0.00.2-0.10.00.10.4
Distance moved, locomotor task time 10.10.20.4-0.3-0.3-0.50.3-0.3-0.30.30.3-0.4-0.5-0.6-0.40.60.50.1
Vertical activity count, locomotor time 10.00.00.1-0.1-0.1-0.20.1-0.1-0.10.10.1-0.2-0.1-0.3-0.20.30.1-0.2
Time >=10cm from walls, locomotor time 20.20.50.60.70.70.7-0.70.70.7-0.7-0.70.70.70.70.7-0.7-0.6-0.8
Bouts of movement, locomotor time 20.10.30.40.50.50.3-0.60.50.6-0.5-0.60.60.40.30.5-0.5-0.5-0.5
Total resting periods, locomotor time 20.10.20.30.50.50.3-0.60.50.6-0.5-0.60.60.40.20.4-0.4-0.4-0.5
Rest time, locomotor task time 20.10.10.20.20.40.3-0.40.40.4-0.4-0.40.40.20.40.2-0.1-0.3-0.1
Distance moved, locomotor task time 20.50.71.1-0.8-0.9-0.80.9-0.9-0.90.90.9-0.9-0.8-0.8-0.90.81.10.7
Vertical activity count, locomotor time 20.20.50.7-0.6-0.7-0.70.7-0.7-0.70.70.7-0.7-0.6-0.8-0.80.80.80.3
Light reinforcement 10.10.61.4-0.8-0.8-0.30.8-0.8-0.80.80.8-1.0-0.8-1.2-0.50.80.50.5
Light reinforcement 20.30.82.0-1.0-0.7-0.10.8-0.8-0.80.70.7-0.9-1.1-1.4-0.71.20.70.7
Bone: marrow area1.84.46.8-1.8-2.3-1.72.4-2.1-2.32.42.3-2.6-1.8-2.1-1.81.41.82.1
Bone: maximum diameter4.99.911.5-3.1-3.2-3.13.2-3.2-3.23.23.2-3.3-3.1-3.4-3.03.13.02.9
Bone: maximum force1.63.13.5-1.7-1.9-1.81.9-1.8-1.91.91.9-1.9-1.6-1.8-1.71.61.71.6
Bone: maximum moment2.34.44.9-2.0-2.2-2.22.2-2.2-2.22.22.2-2.2-2.0-2.1-2.11.92.01.9
Mean time between licks in bursts0.21.22.01.11.10.9-1.11.01.0-1.1-1.11.21.01.01.2-1.4-1.3-1.0
Mean num. licks in bursts0.82.22.9-1.6-1.5-1.31.6-1.5-1.51.51.6-1.5-0.9-1.0-1.71.51.61.7
Cd content in liver1.01.21.8-1.1-1.1-1.41.2-1.2-1.21.11.2-1.0-1.0-0.7-1.11.01.00.9
Co content in liver0.20.30.7-0.6-0.5-0.70.5-0.5-0.50.40.5-0.1-0.9-0.5-0.50.60.40.4
Cu content in liver7.28.69.73.03.02.8-3.13.03.1-3.0-3.12.92.72.53.0-2.6-3.0-3.1
Fe content in liver2.02.53.4-1.5-1.6-1.41.6-1.6-1.61.71.6-1.8-1.5-1.7-1.61.51.51.5
K content in liver1.31.31.71.31.21.1-1.31.21.3-1.2-1.31.10.70.71.2-0.8-1.2-1.2
Mg content in liver1.71.92.41.51.41.4-1.51.51.5-1.4-1.51.20.90.91.5-1.1-1.4-1.5
Mn content in liver0.00.00.10.20.10.1-0.10.10.2-0.2-0.20.1-0.2-0.40.30.3-0.1-0.2
Na content in liver1.51.72.71.31.31.7-1.31.41.3-1.4-1.31.31.21.21.2-1.4-1.2-1.1
Rb content in liver0.20.30.8-0.3-0.5-0.90.4-0.5-0.40.50.4-0.5-0.7-0.7-0.30.50.40.3
Se content in liver1.01.21.81.21.01.0-1.11.11.1-1.0-1.10.91.00.91.3-1.0-1.2-1.2
Sr content in liver2.52.23.21.31.51.3-1.51.41.5-1.6-1.51.81.51.61.4-1.5-1.5-1.3
Zn content in liver0.00.00.10.10.10.1-0.10.10.1-0.1-0.10.10.10.30.2-0.1-0.2-0.1
Bone: minimum diameter0.40.81.3-0.8-0.9-1.00.9-0.9-0.91.00.9-1.0-0.9-1.1-0.61.00.50.7
Time in familiar zone, hab. session 10.20.20.3-0.4-0.5-0.10.5-0.4-0.50.50.5-0.5-0.4-0.2-0.40.40.40.4
Time in novel zone, hab. session 11.01.12.2-1.0-0.9-1.50.9-1.0-0.91.00.9-0.8-1.0-1.3-1.00.91.01.1
Total zone transitions, hab. session 12.02.83.71.71.71.9-1.71.71.7-1.7-1.71.71.51.51.7-1.3-1.7-1.6
Total locomotion distance, hab. session 10.40.61.10.70.81.1-0.80.80.8-0.8-0.80.70.70.60.8-0.5-0.8-0.8
Locomotion velocity, hab. session 10.71.01.90.91.01.4-1.01.01.0-1.0-1.00.80.90.90.9-0.7-1.0-1.0
Time in familiar zone, hab. session 20.10.10.20.20.30.2-0.30.30.3-0.4-0.30.4-0.10.00.4-0.1-0.3-0.3
Time in novel zone, hab. session 20.70.81.2-0.9-0.9-1.00.9-0.9-0.90.90.9-0.9-0.4-0.6-1.10.71.01.0
Total zone transitions, hab. session 20.00.10.40.30.20.6-0.20.30.2-0.2-0.20.00.10.20.2-0.2-0.1-0.1
Total locomotion distance, hab. session 20.10.20.40.40.40.7-0.40.40.4-0.4-0.40.30.30.50.4-0.3-0.4-0.4
Locomotion velocity, hab. session 20.40.51.10.70.71.1-0.70.80.7-0.7-0.70.60.60.80.7-0.6-0.7-0.8
Novel to familiar place preference ratio2.73.55.7-2.0-1.8-2.41.8-1.9-1.81.81.8-1.6-1.9-1.9-1.82.01.81.7
Novelty place preference3.54.57.0-2.2-2.1-2.72.0-2.2-2.12.12.1-1.8-2.2-2.2-2.12.32.02.0
Time in novel zone, NPP test5.06.19.0-2.6-2.4-3.02.4-2.5-2.42.42.4-2.2-2.5-2.5-2.42.62.42.4
Total zone transitions, NPP test0.60.91.51.10.91.2-0.81.00.9-0.9-0.90.81.01.01.1-1.0-1.1-1.0
Total locomotion distance, NPP test0.30.40.70.70.50.8-0.50.60.5-0.5-0.50.50.80.70.7-0.8-0.7-0.7
Locomotion velocity, NPP test1.31.92.41.41.31.5-1.31.31.3-1.3-1.31.21.61.41.5-1.4-1.4-1.5
Intraocular pressure0.30.50.8-0.7-0.7-0.30.7-0.7-0.70.70.7-0.6-0.5-0.4-0.90.60.80.9
Delta distance traveled before/after self-admin1.71.92.7-1.5-1.3-1.41.3-1.4-1.31.31.3-1.3-1.4-1.2-1.51.61.51.0
Delta ambulatory time before/after self-admin1.83.15.4-1.9-1.7-1.81.6-1.7-1.61.61.6-1.6-1.9-1.7-1.92.31.91.4
Parametrial fat weight0.51.21.80.91.20.8-1.31.21.3-1.2-1.31.31.21.00.9-0.6-0.8-1.3
Pavlov. Cond. lever latency2.02.52.9-1.7-1.7-1.41.7-1.6-1.71.61.7-1.5-1.5-1.3-1.71.21.61.7
Pavlov. Cond. magazine entry latency2.12.73.41.71.81.4-1.81.71.8-1.8-1.81.81.61.41.5-1.2-1.5-1.5
Pavlov. Cond. change in total contacts2.42.63.21.71.71.4-1.81.71.8-1.7-1.81.71.61.31.6-1.1-1.5-1.4
Pavlov. Cond. index score1.82.32.91.61.71.3-1.71.61.7-1.6-1.71.61.51.31.5-1.2-1.4-1.4
Pavlov. Cond. latency score1.51.92.31.51.51.1-1.51.41.5-1.5-1.51.51.31.11.4-1.0-1.4-1.4
Pavlov. Cond. lever contacts4.14.95.52.32.32.1-2.32.32.3-2.3-2.32.22.11.92.3-1.8-2.2-2.2
Pavlov. Cond. magazine entry number2.53.14.0-1.9-1.9-1.51.9-1.9-1.91.91.9-2.0-1.8-1.6-1.71.41.61.6
Pavlov. Cond. intertrial magazine entries0.50.61.30.80.70.6-0.70.70.7-0.7-0.70.71.11.00.7-1.0-0.8-0.7
Pavlov. Cond. lever-magazine prob. diff.2.42.93.61.81.91.5-1.91.81.9-1.8-1.91.81.71.51.6-1.4-1.6-1.6
Pavlov. Cond. response bias3.94.95.82.32.42.0-2.42.32.4-2.4-2.42.32.21.82.1-1.8-2.0-2.0
Pavlov. Cond. lever latency0.10.20.3-0.6-0.5-0.40.5-0.5-0.50.40.5-0.3-0.30.1-0.60.40.50.6
Pavlov. Cond. magazine entry latency2.43.44.11.91.81.9-1.91.91.8-1.8-1.81.72.01.61.8-2.0-1.9-1.8
Pavlov. Cond. change in total contacts0.10.10.30.50.40.3-0.40.40.4-0.3-0.40.10.1-0.10.5-0.4-0.5-0.6
Pavlov. Cond. index score1.01.61.91.31.31.2-1.31.31.3-1.2-1.31.11.20.81.4-1.3-1.4-1.3
Pavlov. Cond. latency score1.22.02.31.51.41.4-1.51.51.5-1.4-1.51.31.41.01.5-1.4-1.5-1.5
Pavlov. Cond. lever contacts0.20.30.50.70.60.6-0.70.60.6-0.6-0.60.40.40.00.7-0.5-0.6-0.7
Pavlov. Cond. magazine entry number1.82.32.8-1.7-1.5-1.51.6-1.6-1.61.51.6-1.3-1.6-1.1-1.61.61.61.6
Pavlov. Cond. intertrial magazine entries1.63.44.0-1.9-1.8-2.01.9-1.9-1.91.81.9-1.6-2.0-1.6-1.91.82.01.8
Pavlov. Cond. lever-magazine prob. diff.1.21.82.21.41.41.4-1.41.41.4-1.3-1.41.21.20.81.5-1.4-1.5-1.4
Pavlov. Cond. response bias0.50.71.01.00.90.8-1.00.90.9-0.8-1.00.70.80.21.0-0.8-0.9-0.9
Time in closed arm before self-admin2.54.36.62.02.12.6-2.12.12.1-2.1-2.12.11.82.22.0-1.9-2.0-1.9
Time in closed arm after self-admin1.21.41.71.11.21.0-1.31.21.3-1.2-1.31.31.01.11.2-0.9-1.2-1.2
Time in open arm before self-admin0.10.10.40.20.30.4-0.30.30.3-0.3-0.30.30.50.10.1-0.3-0.0-0.6
Time in open arm after self-admin0.30.30.5-0.4-0.60.00.7-0.6-0.70.70.7-0.7-0.3-0.5-0.5-0.10.50.6
Bone: periosteal estimation1.94.55.9-1.9-2.3-2.12.2-2.1-2.22.32.2-2.4-2.1-2.4-1.82.01.81.9
Bone: periosteal perimeter2.95.67.5-2.4-2.4-2.42.4-2.4-2.42.42.4-2.5-2.5-2.7-2.12.42.12.1
Bone: post-yield work0.30.60.8-0.8-0.8-0.60.9-0.8-0.90.80.9-0.8-0.5-0.5-0.80.60.80.9
Progressive ratio test 1 active lever presses0.00.00.2-0.3-0.2-0.20.2-0.2-0.20.20.2-0.2-0.1-0.4-0.2-0.00.20.1
Progressive ratio test 1 breakpoint0.00.00.0-0.1-0.00.00.0-0.0-0.00.00.1-0.00.1-0.2-0.0-0.2-0.0-0.1
Progressive ratio test 1 inactive lever presses0.10.20.3-0.5-0.5-0.50.5-0.5-0.50.50.5-0.5-0.3-0.5-0.40.00.40.5
Progressive ratio test 2 active lever presses0.10.20.6-0.3-0.5-0.20.5-0.4-0.50.50.5-0.5-0.0-0.4-0.3-0.30.40.8
Progressive ratio test 2 breakpoint0.10.10.5-0.2-0.4-0.10.4-0.3-0.40.40.4-0.40.1-0.3-0.2-0.40.30.7
Progressive ratio test 2 inactive lever presses0.10.30.60.50.50.6-0.40.50.4-0.5-0.40.50.70.40.5-0.8-0.5-0.5
Incentive Sensitization - Responses0.10.30.9-0.4-0.6-0.10.7-0.5-0.70.60.7-0.6-0.2-0.4-0.5-0.20.61.0
Incentive Sensitization - Breakpoint0.20.41.1-0.5-0.7-0.20.8-0.6-0.70.70.7-0.7-0.2-0.5-0.5-0.20.61.0
Sum of active levers in priming session hrs 5-60.00.00.10.1-0.2-0.20.2-0.2-0.20.30.2-0.3-0.10.10.10.2-0.0-0.1
Progressive ratio0.00.10.20.50.40.0-0.40.40.4-0.4-0.40.40.50.50.2-0.4-0.2-0.3
Food seeking constrained by brief footshock0.81.02.1-0.9-0.9-1.10.8-0.9-0.80.90.8-0.9-1.1-1.2-0.91.41.00.8
Seeking ratio, punishment vs. effort0.20.40.7-0.7-0.6-0.40.6-0.6-0.60.60.6-0.6-0.7-0.8-0.50.90.50.4
Retroperitoneal fat weight2.09.012.7-3.1-2.9-3.52.7-2.9-2.72.82.7-2.9-3.0-3.3-3.03.63.22.4
Reaction time number correct0.51.92.81.21.41.5-1.41.41.4-1.4-1.41.41.11.11.4-1.1-1.4-1.7
Reaction time mean minus median0.10.41.0-0.7-0.6-1.00.6-0.7-0.70.60.7-0.4-0.6-0.3-0.80.50.70.7
Reaction time mean minus median AUC0.11.01.3-1.0-1.0-1.11.1-1.1-1.11.01.1-0.8-0.8-0.7-1.10.61.01.1
Reaction time num false alarms0.00.10.1-0.2-0.3-0.30.3-0.2-0.30.30.3-0.3-0.2-0.2-0.20.30.1-0.1
Reaction time num false alarms AUC0.00.10.1-0.2-0.3-0.40.3-0.3-0.30.30.3-0.4-0.2-0.2-0.20.30.1-0.2
Reaction time trials correct on left0.51.92.81.21.41.5-1.41.41.4-1.4-1.41.41.11.11.4-1.1-1.4-1.7
Reaction time trials on left0.61.93.01.21.41.5-1.41.51.4-1.5-1.51.41.11.11.5-1.1-1.4-1.7
Reaction time mean0.00.00.10.10.2-0.0-0.20.10.2-0.2-0.20.3-0.0-0.00.1-0.1-0.2-0.0
Reaction time mean AUC0.00.00.10.10.20.1-0.20.10.2-0.2-0.20.3-0.1-0.10.1-0.0-0.3-0.0
Median of all reaction times0.10.20.30.40.50.4-0.50.40.5-0.5-0.50.50.20.10.4-0.3-0.5-0.3
Reaction time omissions0.00.00.20.20.1-0.3-0.10.10.1-0.1-0.10.20.2-0.10.4-0.0-0.4-0.3
Reaction time false alarm rate0.50.61.0-0.7-0.9-1.00.9-0.9-0.90.90.9-0.8-0.6-0.6-0.80.70.70.6
Reaction time premature initiation rate0.00.00.10.2-0.00.10.00.10.00.1-0.0-0.20.20.00.2-0.1-0.1-0.1
Reaction time premature initiations0.10.40.60.60.50.8-0.60.60.6-0.6-0.60.40.60.50.7-0.6-0.6-0.8
Std. dev. reaction times0.10.41.3-0.6-0.5-1.20.5-0.7-0.50.50.5-0.4-0.8-0.6-0.60.70.40.6
Reaction time trials completed0.61.93.01.21.41.5-1.41.51.4-1.5-1.51.41.11.11.5-1.1-1.4-1.7
Reaction time trials AUC0.41.52.41.01.21.3-1.21.31.3-1.3-1.31.20.90.91.3-0.9-1.3-1.5
Run reversals in cocaine runway, females1.31.52.21.21.41.1-1.51.31.4-1.4-1.51.31.10.80.9-0.8-0.9-1.1
Run reversals in cocaine runway, males1.81.92.6-1.4-1.4-1.41.4-1.4-1.41.41.4-1.4-1.3-1.1-1.51.61.51.3
Latency to leave start box in cocaine runway0.20.30.5-0.5-0.6-0.20.7-0.6-0.70.60.7-0.6-0.3-0.4-0.50.10.60.7
Latency to leave start box in cocaine runway, F0.10.10.2-0.0-0.20.40.3-0.1-0.30.20.3-0.30.20.1-0.0-0.40.10.5
Latency to leave start box in cocaine runway, M0.70.70.9-0.9-0.9-0.80.9-0.9-0.90.80.9-0.8-0.8-0.9-0.90.70.90.5
Std. dev. time between licks in bursts0.51.01.41.11.00.9-1.11.01.1-1.0-1.10.90.80.71.2-0.9-1.2-1.0
Total sessions with >9 infusions2.53.14.1-1.8-1.8-2.01.8-1.8-1.81.91.8-1.9-1.7-1.8-1.51.31.41.8
Short access day 1 total inactive lever presses2.04.04.6-2.1-2.1-2.02.1-2.1-2.12.12.1-2.1-2.0-2.0-1.82.01.81.6
Short access day 10 total inactive lever presses0.42.43.2-1.7-1.6-1.31.6-1.6-1.51.51.5-1.5-1.7-1.6-1.71.81.61.3
Short access day 1 total infusions1.22.32.9-1.6-1.5-1.71.5-1.5-1.51.51.5-1.5-1.5-1.4-1.51.31.51.7
Short access day 10 total infusions0.00.10.2-0.3-0.2-0.50.2-0.2-0.20.20.2-0.3-0.2-0.4-0.10.00.2-0.1
Short access total infusions1.42.02.2-1.5-1.5-1.51.5-1.4-1.41.51.4-1.5-1.4-1.4-1.31.11.21.5
Short access day 1 locomotion0.10.10.3-0.3-0.4-0.30.5-0.4-0.50.50.5-0.5-0.2-0.4-0.0-0.10.20.6
Short access day 10 total locomotion0.31.11.91.10.90.9-0.91.00.9-0.9-0.90.91.20.91.3-1.4-1.3-1.1
Short access total locomotion0.00.00.20.0-0.0-0.3-0.0-0.00.00.1-0.0-0.10.0-0.30.4-0.3-0.4-0.1
One hour access (0.3 mA shock)0.50.62.00.80.60.9-0.50.70.6-0.6-0.60.61.00.50.9-1.4-0.8-0.8
Compulsive drug intake0.10.10.30.0-0.3-0.50.3-0.3-0.30.30.3-0.3-0.1-0.2-0.10.40.10.2
One hour access (shock baseline)0.30.72.10.70.71.3-0.60.80.6-0.7-0.60.71.00.90.8-1.4-0.7-0.6
Social response proportion0.20.20.4-0.7-0.4-0.60.4-0.4-0.40.40.4-0.30.1-0.4-0.60.20.60.5
Social responses0.10.10.40.30.4-0.2-0.50.30.4-0.3-0.40.30.4-0.10.4-0.0-0.4-0.6
Social time2.13.44.01.71.91.7-1.91.81.9-1.8-1.91.81.91.81.8-2.0-2.0-1.6
Soleus weight0.10.40.7-0.7-0.7-0.10.8-0.6-0.70.70.8-0.7-0.2-0.2-0.90.60.80.8
Bone: stiffness0.61.01.3-0.9-1.1-1.11.1-1.0-1.01.11.0-1.1-0.9-1.1-0.91.00.80.8
Tibialis anterior weight0.41.32.61.01.10.9-1.01.01.0-1.1-1.01.31.51.61.0-1.1-1.0-1.0
Time to tail flick, vehicle, before self-admin0.40.41.3-0.6-0.6-1.10.6-0.7-0.60.70.6-0.6-0.7-0.7-0.60.70.50.5
Time to tail flick, vehicle, after self-admin0.00.10.20.40.20.4-0.20.20.2-0.2-0.20.30.40.10.4-0.4-0.4-0.1
Time to tail flick, test, before self-admin0.20.20.6-0.4-0.3-0.10.3-0.4-0.30.30.3-0.3-0.7-0.7-0.50.80.50.5
Time to tail flick, test, after self-admin1.11.22.11.21.01.1-1.01.01.0-1.0-1.01.01.31.41.3-1.1-1.2-0.7
Delta time to tail flick, vehicle, before/after SA0.30.30.7-0.4-0.6-0.10.7-0.5-0.60.60.7-0.6-0.4-0.5-0.50.00.50.9
Delta time to tail flick, test, before/after SA1.82.23.91.61.31.3-1.21.41.2-1.2-1.21.21.92.01.6-1.8-1.6-1.2
Tibia length0.82.43.2-1.4-1.6-1.81.6-1.6-1.51.61.5-1.7-1.4-1.6-1.41.71.41.2
Ambulatory time before self-admin0.00.10.40.30.40.6-0.30.30.3-0.3-0.30.30.30.20.3-0.6-0.30.4
Ambulatory time after self-admin0.00.00.1-0.10.10.3-0.10.10.1-0.1-0.10.1-0.10.2-0.20.30.10.4
Bone: tissue strength0.30.30.7-0.5-0.7-0.50.7-0.6-0.70.70.7-0.8-0.3-0.6-0.50.30.50.6
Total heroin consumption1.01.21.6-0.9-1.1-1.01.1-1.1-1.11.11.1-1.1-1.1-0.9-1.11.31.20.8
Bone: trabecular number0.30.51.00.70.61.0-0.60.70.6-0.6-0.60.60.90.90.5-0.9-0.5-0.5
Bone: trabecular spacing1.01.42.1-1.2-1.2-1.41.2-1.2-1.21.21.2-1.2-1.2-1.3-1.11.11.11.1
Bone: trabecular thickness0.50.71.00.81.00.9-1.00.91.0-1.0-1.00.90.50.70.8-0.9-0.8-0.8
Bone: trabecular tissue density0.81.51.91.41.20.7-1.21.11.2-1.2-1.21.31.31.01.3-1.3-1.3-1.3
Water consumed over 24 hours2.44.65.7-2.4-2.1-1.82.2-2.2-2.22.12.2-2.0-1.7-1.8-2.42.32.42.3
Number of responses in last shaping day0.60.81.20.90.91.1-0.90.91.0-1.0-0.90.90.90.80.9-0.8-0.8-0.6