Hub : Genes

LOC134479944

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC134479944	0.04	0.03	6.5e-04	0.02	0.03	0.01	0.02	8.1e-03	8.5e-04	5.1e-02	5.0e-03
2	Liver	gene expression	LOC134479944	0.03	0.02	5.5e-04	0.02	0.01	0	0.01	6.5e-03	2.3e-02	7.2e-02	1.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.6	1.0	1.1	1.1	-1.0
Area under the delay curve	0.3	0.4	0.8	0.1	-0.9
BMI with tail	0.3	1.0	1.3	-1.1	0.9
BMI without tail	0.0	0.2	0.3	0.2	-0.5
Body weight	0.6	2.8	3.6	-1.9	1.4
Weight adjusted by age	0.0	0.1	0.3	-0.5	-0.1
Bone surface	0.5	0.9	1.6	0.5	-1.2
Bone volume	0.1	0.2	0.4	0.3	-0.6
Breakpoint value in progressive ratio session	0.1	0.2	0.2	0.5	-0.3
Number of licking bursts	0.4	1.2	2.0	0.6	-1.4
Context. condit. distance diff. score	8.7	10.5	10.7	-3.2	3.3
Locomotion velocity, session 1	0.4	0.4	0.6	-0.5	-0.8
Locomotion distance, session 1	1.5	1.9	2.8	1.0	-1.7
Locomotion velocity, session 2	0.1	0.1	0.3	-0.5	-0.1
Locomotion distance, session 2	4.3	6.0	7.3	2.2	-2.7
Locomotion velocity, session 3	1.0	1.2	1.3	-1.0	1.1
Locomotion distance, session 3	0.0	0.0	0.0	0.0	0.0
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	-0.7	-0.0
Stereotopy head waving duration, day 3	1.5	1.9	2.8	-1.7	1.0
Locomotion velocity, session 7	0.5	0.5	0.6	-0.8	0.6
Locomotion distance, session 7	0.0	0.0	0.1	0.0	0.3
Stereotopy head waving bouts, day 7	3.0	3.5	4.6	-2.1	1.6
Stereotopy head waving duration, day 7	3.0	3.7	3.9	-1.9	2.0
Locomotion velocity, session 8	0.9	1.0	2.1	-1.4	0.0
Locomotion distance, session 8	1.2	1.8	1.9	-1.3	1.4
Degree of sensitization distance	0.5	0.5	0.6	-0.7	0.8
Degree of sensitization stereotypy	2.6	2.9	3.5	-1.9	1.5
Conditioned locomotion	1.1	1.3	1.5	-1.2	1.1
Cocaine response after cond. corrected	0.2	0.3	0.5	-0.4	0.7
Cocaine response after cond. not corrected	0.2	0.3	0.5	-0.3	0.7
Cocaine response before conditioning	0.1	0.1	0.2	0.4	-0.2
Saline control response	0.4	0.5	0.7	-0.6	0.8
Bone: connectivity density	0.3	0.4	0.5	0.6	-0.7
Bone: cortical apparent density	0.5	0.9	0.9	0.9	-0.9
Bone: cortical area	0.5	0.8	1.2	-1.1	0.5
Bone: cortical porosity	0.5	0.6	1.0	-0.4	1.0
Bone: cortical porosity	1.3	1.4	1.7	-1.1	1.3
Bone: cortical thickness	0.1	0.1	0.2	0.1	-0.4
Bone: cortical thickness	0.2	0.3	0.5	-0.0	-0.7
Bone: cortical tissue density	0.5	0.8	0.9	0.9	-1.0
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	0.6	-1.0
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	-0.6	0.5
Condit. Reinf. active responses	1.4	1.9	2.3	1.5	-1.2
Condit. Reinf. inactive responses	2.0	2.6	3.8	2.0	-1.2
Incentive salience index mean	0.9	1.2	1.4	1.0	-1.2
Condit. Reinf. lever presses	1.0	1.4	1.5	1.2	-1.2
Condit. Reinf. active minus inactive responses	0.8	1.2	2.3	0.4	-1.5
Condit. Reinf. active-inactive response ratio	0.8	1.2	2.3	0.4	-1.5
Condit. Reinf. active responses	0.2	0.4	0.4	-0.6	-0.6
Condit. Reinf. inactive responses	0.7	1.0	1.8	-1.3	0.6
Condit. Reinf. lever presses	0.6	0.9	0.9	1.0	-0.9
Condit. Reinf. lever reinforcers received	0.2	0.3	0.5	-0.2	-0.7
Conditioned reinforcement - actives	0.1	0.4	0.7	-0.8	-0.1
Conditioned reinforcement - inactives	0.5	1.5	2.4	0.7	-1.5
Conditioned locomotion	0.2	0.3	0.7	-0.8	-0.0
Patch foraging indifference point 0 sec	0.7	2.1	2.1	1.4	-1.5
Patch foraging indifference point AUC	0.2	0.4	0.9	0.1	-0.9
Delay disc. indifference point, 0s delay	0.7	0.8	1.1	-0.7	1.1
Delay disc. indifference point, 16s delay	1.0	1.4	2.0	0.9	-1.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.3	-0.3
Delay disc. indifference point, 24s delay	0.5	0.9	1.6	-0.3	-1.3
Delay disc. indifference point, 4s delay	0.6	0.6	1.1	0.3	-1.1
Delay disc. indifference point, 8s delay	0.4	0.7	1.1	0.6	-1.0
Indifference point function ln k	0.3	1.1	1.5	-0.8	1.2
Indifference point function log k	0.3	1.1	1.5	-0.8	1.2
Patch foraging total patch changes 0 sec	0.8	2.2	2.4	1.5	-1.4
Patch foraging total patch changes 12 sec	0.2	0.3	0.4	0.3	-0.7
Patch foraging total patch changes 18 sec	0.5	1.2	1.7	0.8	-1.3
Patch foraging total patch changes 24 sec	0.1	0.2	0.3	0.5	-0.4
Patch foraging total patch changes 6 sec	1.6	2.7	4.2	1.1	-2.0
Patch foraging time to switch 0 sec	0.1	0.6	1.1	0.1	1.0
Patch foraging water rate 0 sec	0.3	1.2	1.7	0.8	-1.3
Patch foraging water rate 12 sec	0.2	0.7	0.7	0.9	-0.8
Patch foraging water rate 18 sec	1.3	2.9	3.6	1.5	-1.9
Patch foraging water rate 24 sec	0.2	0.3	0.4	0.4	-0.6
Patch foraging water rate 6 sec	0.5	0.8	0.9	0.8	-0.9
Seeking ratio, delayed vs. immediate footshock	2.6	3.8	4.6	2.2	-1.7
Distance traveled before self-admin	0.2	0.5	0.9	1.0	-0.3
Distance traveled after self-admin	1.3	2.2	3.4	1.0	-1.8
Extensor digitorum longus weight	0.1	0.3	0.7	0.8	-0.1
Bone: elastic displacement	0.1	0.1	0.2	-0.5	0.1
Bone: elastic work	1.1	1.4	1.7	-1.3	1.0
Bone: endosteal estimation	0.7	1.7	1.8	-1.4	1.3
Bone: endosteal perimeter	1.4	3.5	4.5	-2.1	1.6
Epididymis fat weight	1.9	9.8	12.1	-2.8	3.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.4	-0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.1	0.5
Diff in mean of infusions in LGA sessions	0.1	0.2	0.3	-0.2	-0.5
Delay discount exponential model param	0.4	0.5	1.0	-0.1	1.0
Extinction: sum of active levers before priming	0.3	0.4	0.6	-0.8	0.4
Active lever presses in extinction session 6	0.1	0.1	0.1	-0.3	0.4
Bone: final force	0.3	0.4	0.7	-0.8	0.4
Bone: final moment	0.3	0.5	0.8	-0.9	0.4
Food consumed during 24 hour testing period	0.2	0.5	0.9	-1.0	0.1
Glucose	0.2	0.2	0.4	0.7	-0.2
Heart weight	3.0	4.8	6.5	-2.6	1.7
Delay discount hyperbolic model param	0.3	0.4	0.8	-0.1	0.9
Intermittent access intake day 1-15 change	0.1	0.3	0.6	0.7	-0.3
Intermittent access intake escalation	0.1	0.4	0.6	0.8	-0.5
Intermittent access intake escalation 2	0.2	0.3	0.6	0.8	0.1
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	0.4	-0.2
Intermitt. access day 15 inactive lever presses	0.2	1.2	1.5	1.0	-1.2
Intermitt. access escalation Index	0.2	0.7	0.9	0.7	-1.0
Intermittent access day 1 total infusions	0.1	0.2	0.3	-0.5	-0.1
Intermittent access day 15 total infusions	0.0	0.1	0.1	0.2	-0.3
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.1	0.2
Intermittent access total infusions	0.0	0.1	0.1	-0.3	0.1
Intermittent access day 1 locomotion	0.0	0.1	0.1	0.4	-0.2
Intermittent access day 15 total locomotion	0.0	0.0	0.1	-0.1	0.2
Intermittent access total locomotion	0.0	0.0	0.1	-0.1	0.3
Intermittent access standard deviation	0.2	0.8	1.7	-0.1	1.3
Left kidney weight	3.6	29.3	40.4	-6.4	4.3
Right kidney weight	4.3	30.2	39.7	-6.3	4.5
Cocaine induced anxiety	0.2	0.6	0.9	-0.6	0.9
Post-drug Anxiety	0.0	0.0	0.0	0.0	0.2
Baseline Anxiety	0.6	0.9	1.3	0.8	-1.1
Tail length	0.1	0.4	0.7	0.8	-0.2
Length with tail	0.3	1.3	1.3	-1.1	1.1
Length without tail	0.8	4.2	4.5	-2.1	2.0
Times rat made contact with spout	0.3	0.3	0.5	-0.7	-0.4
Lifetime Intake	0.1	0.1	0.2	-0.4	-0.2
Liver weight, left	2.3	4.0	4.8	-2.2	1.8
Liver weight, right	4.9	8.6	9.8	-2.7	3.1
Locomotor activity	1.6	2.5	2.9	-1.7	1.4
Locomotor testing distance	0.0	0.1	0.1	0.3	-0.2
Locomotor testing rearing	0.6	2.3	2.6	-1.6	1.4
Locomotion in novel chamber	0.0	0.0	0.0	-0.1	-0.1
Locomotion in novel chamber post-restriction	0.1	0.2	0.4	0.6	0.0
Fecal boli incidents, locomotor time 1	0.2	0.5	0.7	0.5	-0.9
Change in fecal boli incidents, locomotor task	0.8	0.9	1.8	-1.3	0.0
Time >=10cm from walls, locomotor time 1	0.0	0.1	0.1	-0.2	0.2
Bouts of movement, locomotor time 1	0.9	1.1	1.4	-0.9	1.2
Total resting periods, locomotor time 1	0.3	0.3	0.4	-0.4	0.7
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.4	0.3
Distance moved, locomotor task time 1	0.3	0.9	1.1	-0.8	1.0
Vertical activity count, locomotor time 1	0.0	0.0	0.0	0.1	0.1
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.5	0.4	-0.7
Bouts of movement, locomotor time 2	0.0	0.1	0.2	-0.1	0.5
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.0	0.2
Rest time, locomotor task time 2	0.2	0.3	0.5	0.2	-0.7
Distance moved, locomotor task time 2	1.1	1.4	1.8	-1.0	1.3
Vertical activity count, locomotor time 2	0.1	0.2	0.3	-0.4	0.6
Light reinforcement 1	0.0	0.1	0.2	-0.4	-0.3
Light reinforcement 2	0.6	1.3	1.3	-1.1	1.1
Bone: marrow area	0.7	1.7	1.9	-1.4	1.2
Bone: maximum diameter	1.5	3.1	5.1	-2.2	1.0
Bone: maximum force	0.4	0.9	1.5	-1.2	0.5
Bone: maximum moment	0.6	1.1	1.8	-1.3	0.6
Mean time between licks in bursts	0.1	0.5	0.7	0.8	-0.5
Mean num. licks in bursts	0.8	2.2	2.4	-1.5	1.4
Cd content in liver	1.0	1.1	2.1	-1.4	-0.3
Co content in liver	1.0	1.1	2.1	0.4	-1.5
Cu content in liver	6.5	7.8	8.4	2.9	-2.7
Fe content in liver	0.1	0.1	0.1	-0.3	0.3
K content in liver	0.9	0.9	1.2	1.1	-0.7
Mg content in liver	1.3	1.5	1.9	1.4	-1.0
Mn content in liver	0.2	0.3	0.3	-0.5	0.5
Na content in liver	1.5	1.7	2.6	1.6	-0.9
Rb content in liver	0.1	0.1	0.2	0.0	-0.5
Se content in liver	0.1	0.1	0.2	0.4	-0.1
Sr content in liver	1.6	1.4	1.8	1.3	-1.0
Zn content in liver	0.1	0.1	0.2	-0.0	-0.4
Bone: minimum diameter	0.4	0.8	0.9	-1.0	0.8
Time in familiar zone, hab. session 1	0.2	0.3	0.3	-0.6	-0.4
Time in novel zone, hab. session 1	0.6	0.6	1.2	-0.3	1.1
Total zone transitions, hab. session 1	1.5	2.1	2.5	1.3	-1.6
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.4	-0.3
Locomotion velocity, hab. session 1	0.5	0.6	0.7	0.8	-0.8
Time in familiar zone, hab. session 2	0.8	0.9	1.3	-0.7	1.1
Time in novel zone, hab. session 2	0.4	0.4	0.6	0.4	-0.8
Total zone transitions, hab. session 2	2.3	2.9	4.8	1.0	-2.2
Total locomotion distance, hab. session 2	1.6	2.1	3.0	1.1	-1.7
Locomotion velocity, hab. session 2	2.3	3.1	4.2	1.4	-2.0
Novel to familiar place preference ratio	2.1	2.8	2.8	-1.7	1.7
Novelty place preference	3.2	4.1	4.2	-2.1	2.0
Time in novel zone, NPP test	3.8	4.7	5.1	-2.3	2.1
Total zone transitions, NPP test	2.0	2.9	3.9	1.4	-2.0
Total locomotion distance, NPP test	1.4	1.9	2.4	1.2	-1.6
Locomotion velocity, NPP test	1.5	2.2	2.3	1.4	-1.5
Intraocular pressure	0.6	1.0	1.1	-1.0	0.9
Delta distance traveled before/after self-admin	0.6	0.6	0.7	-0.9	-0.7
Delta ambulatory time before/after self-admin	0.5	0.9	0.9	-0.9	-0.9
Parametrial fat weight	0.5	1.2	1.9	-0.7	1.4
Pavlov. Cond. lever latency	0.6	0.8	0.9	-1.0	0.8
Pavlov. Cond. magazine entry latency	1.0	1.3	1.6	1.0	-1.3
Pavlov. Cond. change in total contacts	3.3	3.5	4.9	1.5	-2.2
Pavlov. Cond. index score	0.8	1.0	1.1	0.9	-1.1
Pavlov. Cond. latency score	0.6	0.8	0.9	0.9	-0.9
Pavlov. Cond. lever contacts	1.6	1.9	2.4	1.6	-1.2
Pavlov. Cond. magazine entry number	0.9	1.2	1.5	-1.0	1.2
Pavlov. Cond. intertrial magazine entries	1.5	1.8	1.8	1.3	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.3	0.9	-1.1
Pavlov. Cond. response bias	1.2	1.5	1.6	1.2	-1.3
Pavlov. Cond. lever latency	2.0	2.8	2.9	-1.7	1.7
Pavlov. Cond. magazine entry latency	5.0	7.0	8.1	2.8	-2.4
Pavlov. Cond. change in total contacts	2.1	5.0	6.3	1.9	-2.5
Pavlov. Cond. index score	3.4	5.3	5.7	2.4	-2.2
Pavlov. Cond. latency score	4.1	6.6	7.0	2.6	-2.5
Pavlov. Cond. lever contacts	2.2	3.2	3.4	1.9	-1.7
Pavlov. Cond. magazine entry number	3.7	4.9	5.1	-2.3	2.2
Pavlov. Cond. intertrial magazine entries	0.9	1.9	2.7	-1.6	1.1
Pavlov. Cond. lever-magazine prob. diff.	3.5	5.4	6.1	2.5	-2.2
Pavlov. Cond. response bias	3.0	4.1	4.2	2.0	-2.0
Time in closed arm before self-admin	2.8	4.9	7.6	2.8	-1.5
Time in closed arm after self-admin	0.1	0.1	0.2	-0.1	0.5
Time in open arm before self-admin	0.2	0.3	0.4	-0.5	0.6
Time in open arm after self-admin	0.1	0.2	0.3	-0.2	0.5
Bone: periosteal estimation	0.8	1.9	2.4	-1.5	1.2
Bone: periosteal perimeter	2.5	5.0	6.7	-2.6	1.8
Bone: post-yield work	0.2	0.3	0.5	-0.2	-0.7
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.2	-0.2
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.2	-0.1
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.2	0.5	-0.3
Progressive ratio test 2 active lever presses	0.2	0.3	0.6	-0.0	-0.8
Progressive ratio test 2 breakpoint	0.2	0.3	0.6	-0.0	-0.8
Progressive ratio test 2 inactive lever presses	0.2	0.5	0.9	0.9	-0.3
Incentive Sensitization - Responses	0.2	0.6	1.1	0.2	-1.1
Incentive Sensitization - Breakpoint	0.2	0.5	1.0	0.2	-1.0
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.1	0.3
Progressive ratio	0.1	0.2	0.3	0.6	0.2
Food seeking constrained by brief footshock	0.7	0.8	1.5	-1.2	0.4
Seeking ratio, punishment vs. effort	0.2	0.4	0.9	-0.9	-0.0
Retroperitoneal fat weight	3.6	16.0	16.7	-4.1	3.9
Reaction time number correct	0.0	0.1	0.1	0.4	-0.4
Reaction time mean minus median	0.1	0.6	1.0	-0.5	1.0
Reaction time mean minus median AUC	0.3	2.2	3.1	-1.1	1.8
Reaction time num false alarms	0.1	0.1	0.2	-0.3	0.4
Reaction time num false alarms AUC	0.1	0.1	0.2	-0.3	0.4
Reaction time trials correct on left	0.0	0.1	0.1	0.4	-0.4
Reaction time trials on left	0.0	0.1	0.1	0.4	-0.4
Reaction time mean	0.1	0.2	0.3	0.6	0.1
Reaction time mean AUC	0.0	0.1	0.2	0.5	0.1
Median of all reaction times	0.3	0.4	0.8	0.9	-0.3
Reaction time omissions	0.1	0.1	0.2	-0.1	0.4
Reaction time false alarm rate	0.2	0.2	0.4	-0.4	0.6
Reaction time premature initiation rate	1.4	2.1	2.6	1.3	-1.6
Reaction time premature initiations	0.5	1.6	2.0	1.1	-1.4
Std. dev. reaction times	0.2	0.8	1.2	-0.6	1.1
Reaction time trials completed	0.0	0.1	0.1	0.4	-0.4
Reaction time trials AUC	0.0	0.1	0.1	0.3	-0.3
Run reversals in cocaine runway, females	0.0	0.1	0.1	0.0	-0.3
Run reversals in cocaine runway, males	1.8	2.0	2.7	-1.6	1.2
Latency to leave start box in cocaine runway	0.4	0.6	1.0	-0.4	1.0
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.2	-0.0
Latency to leave start box in cocaine runway, M	1.7	1.6	2.5	-0.8	1.6
Std. dev. time between licks in bursts	1.9	3.6	3.9	1.8	-2.0
Total sessions with >9 infusions	0.8	0.9	1.9	-1.4	-0.2
Short access day 1 total inactive lever presses	0.5	0.9	1.8	0.0	-1.4
Short access day 10 total inactive lever presses	0.1	1.0	1.2	-0.9	1.1
Short access day 1 total infusions	0.1	0.2	0.2	-0.5	-0.3
Short access day 10 total infusions	0.1	0.2	0.4	-0.6	0.3
Short access total infusions	0.3	0.4	0.4	-0.7	-0.6
Short access day 1 locomotion	0.0	0.0	0.0	-0.0	0.1
Short access day 10 total locomotion	0.1	0.4	0.8	0.9	0.2
Short access total locomotion	0.0	0.0	0.0	-0.1	0.2
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.4	0.1
Compulsive drug intake	1.3	2.0	3.9	0.3	-2.0
One hour access (shock baseline)	0.3	0.7	1.3	0.3	1.1
Social response proportion	0.1	0.2	0.3	0.5	-0.1
Social responses	0.1	0.1	0.3	0.0	-0.5
Social time	1.4	2.2	2.5	1.6	-1.4
Soleus weight	0.6	1.7	3.2	0.5	-1.8
Bone: stiffness	0.2	0.3	0.6	-0.7	0.3
Tibialis anterior weight	0.7	2.6	3.2	1.8	-1.4
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.0	-0.2
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.2	0.4	-0.1
Time to tail flick, test, before self-admin	1.5	1.7	1.7	-1.3	1.3
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.1	-0.2
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.1	0.1
Delta time to tail flick, test, before/after SA	2.4	2.9	3.0	1.7	-1.7
Tibia length	0.4	1.0	2.0	-1.4	0.1
Ambulatory time before self-admin	0.1	0.3	0.6	0.8	-0.4
Ambulatory time after self-admin	2.1	3.3	5.1	1.3	-2.3
Bone: tissue strength	0.1	0.1	0.1	-0.4	0.3
Total heroin consumption	0.1	0.2	0.3	-0.3	-0.5
Bone: trabecular number	0.0	0.1	0.1	-0.2	0.3
Bone: trabecular spacing	0.4	0.6	1.0	-1.0	0.3
Bone: trabecular thickness	0.2	0.3	0.6	0.8	0.0
Bone: trabecular tissue density	2.4	4.1	5.5	2.3	-1.7
Water consumed over 24 hours	0.1	0.3	0.3	-0.5	-0.5
Number of responses in last shaping day	2.1	2.7	3.5	1.9	-1.4