LOC134479938

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC134479938	0.09	0.04	9.6e-10	0.09	0.09	0.09	0.09	7.0e-10	6.4e-10	1.6e-10	1.9e-10
2	RMTg	gene expression	LOC134479938	0.13	0.07	8.5e-03	0.08	0.1	0.04	0.04	3.6e-03	1.4e-03	4.2e-02	3.3e-02
3	pVTA	intron excision ratio	chr7_113102356_113102760	0.09	0.05	2.8e-05	0.07	0.05	0.07	0.07	1.8e-06	6.4e-05	2.4e-06	3.8e-06
4	pVTA	intron excision ratio	chr7_113102356_113102850	0.09	0.05	1.1e-05	0.08	0.06	0.07	0.07	9.6e-07	2.5e-05	2.1e-06	4.4e-06
5	PL	gene expression	LOC134479938	0.07	0.03	8.8e-07	0.05	0.04	0.04	0.05	1.4e-06	1.6e-05	1.8e-05	6.0e-06
6	PL	intron excision ratio	chr7_113102356_113102760	0.05	0.03	4.6e-05	0.04	0.04	0.03	0.04	1.1e-05	3.3e-05	7.5e-04	3.0e-05
7	PL	intron excision ratio	chr7_113102356_113102850	0.04	0.02	1.7e-04	0.04	0.03	0.02	0.03	3.6e-05	2.6e-04	3.0e-03	1.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.0	0.0	0.2	-0.5	0.1	0.1	-0.1	-0.1	0.0	-0.0
Area under the delay curve	1.0	1.5	5.0	-2.2	2.0	-0.5	0.5	0.7	-0.6	0.6
BMI with tail	0.3	0.9	2.0	1.4	-1.3	0.5	-0.5	-1.1	0.7	-0.7
BMI without tail	0.1	0.8	1.4	0.6	-1.1	0.6	-0.6	-1.2	0.9	-0.9
Body weight	0.5	2.3	9.2	2.6	-3.0	-0.2	0.2	-0.4	0.1	-0.1
Weight adjusted by age	0.2	0.6	1.1	0.7	-0.8	1.0	-1.0	-0.4	0.5	-0.5
Bone surface	0.1	0.2	0.4	-0.6	0.2	-0.3	0.3	0.6	-0.4	0.4
Bone volume	0.0	0.0	0.1	-0.2	0.3	0.1	-0.1	0.0	0.0	-0.0
Breakpoint value in progressive ratio session	0.1	0.2	0.4	-0.3	0.2	-0.6	0.6	0.6	-0.3	0.3
Number of licking bursts	0.2	0.6	1.7	-1.0	1.3	0.3	-0.3	-0.4	0.8	-0.8
Context. condit. distance diff. score	2.8	3.4	12.2	3.5	-2.3	1.1	-1.1	-1.1	1.2	-1.2
Locomotion velocity, session 1	0.9	1.0	1.7	-0.7	-0.6	-1.0	1.0	1.3	-1.1	1.1
Locomotion distance, session 1	1.4	1.8	7.0	-2.6	2.2	-0.2	0.2	0.4	-0.3	0.3
Locomotion velocity, session 2	0.1	0.1	0.2	0.1	-0.4	-0.3	0.3	0.4	-0.4	0.4
Locomotion distance, session 2	2.7	3.8	11.6	-3.4	2.1	-1.3	1.3	1.6	-1.5	1.5
Locomotion velocity, session 3	2.1	2.4	3.4	1.9	-0.8	1.8	-1.8	-1.5	1.4	-1.4
Locomotion distance, session 3	2.9	3.4	4.8	0.2	1.6	2.2	-2.2	-1.9	1.9	-1.9
Stereotopy head waving bouts, day 3	1.1	1.3	1.7	0.2	-1.3	-1.2	1.2	1.1	-1.2	1.2
Stereotopy head waving duration, day 3	2.1	2.6	7.7	1.3	-2.8	-1.5	1.5	1.2	-1.3	1.3
Locomotion velocity, session 7	0.3	0.4	2.1	1.4	-0.7	0.2	-0.2	-0.1	0.2	-0.2
Locomotion distance, session 7	0.5	0.6	1.3	0.1	-0.2	-0.9	0.9	1.1	-0.9	0.9
Stereotopy head waving bouts, day 7	2.5	2.9	6.9	2.6	-2.3	1.2	-1.2	-1.5	1.2	-1.2
Stereotopy head waving duration, day 7	2.6	3.2	6.7	2.6	-2.2	1.4	-1.4	-1.7	1.4	-1.4
Locomotion velocity, session 8	1.0	1.3	3.7	1.4	-1.9	-0.9	0.9	0.8	-0.7	0.7
Locomotion distance, session 8	0.3	0.4	0.8	0.9	-0.8	0.7	-0.7	-0.4	0.3	-0.3
Degree of sensitization distance	4.7	5.1	6.2	0.6	-2.4	-2.5	2.5	2.4	-2.4	2.4
Degree of sensitization stereotypy	2.4	2.7	5.3	2.3	-1.9	1.4	-1.4	-1.5	1.3	-1.3
Conditioned locomotion	0.3	0.3	1.4	0.9	-1.2	-0.2	0.2	0.2	-0.3	0.3
Cocaine response after cond. corrected	0.8	1.2	2.1	-0.4	-0.7	-0.9	0.9	1.3	-1.5	1.5
Cocaine response after cond. not corrected	0.4	0.6	1.2	-0.3	-0.5	-0.6	0.6	0.9	-1.1	1.1
Cocaine response before conditioning	0.9	1.1	1.5	0.1	0.8	1.1	-1.1	-1.2	1.2	-1.2
Saline control response	0.5	0.7	1.1	1.0	-0.5	1.1	-1.1	-0.6	0.8	-0.8
Bone: connectivity density	0.1	0.1	0.3	-0.1	-0.4	-0.4	0.4	0.5	-0.3	0.3
Bone: cortical apparent density	2.0	3.2	4.9	0.7	0.8	2.2	-2.2	-1.8	2.0	-2.0
Bone: cortical area	0.7	1.1	1.8	0.1	-0.8	-1.2	1.2	1.3	-1.1	1.1
Bone: cortical porosity	1.0	1.1	1.4	0.5	-1.1	-1.0	1.0	1.1	-1.2	1.2
Bone: cortical porosity	2.5	2.8	3.3	0.8	-1.8	-1.8	1.8	1.7	-1.8	1.8
Bone: cortical thickness	0.3	0.4	1.1	-0.7	1.1	-0.5	0.5	0.7	-0.5	0.5
Bone: cortical thickness	1.1	1.3	2.2	-1.5	1.4	-1.2	1.2	1.1	-0.6	0.6
Bone: cortical tissue density	1.8	2.8	4.4	0.7	0.7	2.1	-2.1	-1.7	1.9	-1.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.3	0.6	0.3	-0.3	0.2	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.8	0.7	0.1	0.9	-0.9	-0.2	0.6	-0.6
Condit. Reinf. active responses	0.5	0.7	1.0	-0.7	1.0	0.9	-0.9	-0.5	0.9	-0.9
Condit. Reinf. inactive responses	0.9	1.2	1.4	-0.8	1.1	1.0	-1.0	-1.2	1.2	-1.2
Incentive salience index mean	0.1	0.2	0.5	-0.6	0.7	0.4	-0.4	0.1	0.2	-0.2
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.5	0.6	0.4	-0.4	-0.3	0.3	-0.3
Condit. Reinf. active minus inactive responses	1.2	1.9	2.9	-1.2	0.6	-1.6	1.6	1.7	-1.3	1.3
Condit. Reinf. active-inactive response ratio	1.2	1.9	3.0	-0.7	-0.2	-1.5	1.5	1.7	-1.5	1.5
Condit. Reinf. active responses	1.2	1.7	2.8	-0.6	0.2	-1.7	1.7	1.6	-1.3	1.3
Condit. Reinf. inactive responses	0.2	0.3	0.6	0.0	0.5	-0.8	0.8	0.5	-0.4	0.4
Condit. Reinf. lever presses	0.2	0.3	0.8	-0.9	0.8	-0.3	0.3	0.4	-0.5	0.5
Condit. Reinf. lever reinforcers received	1.4	2.0	3.0	-0.6	0.0	-1.7	1.7	1.7	-1.5	1.5
Conditioned reinforcement - actives	0.4	1.7	3.5	-1.4	1.9	-1.1	1.1	1.0	-1.2	1.2
Conditioned reinforcement - inactives	1.3	3.6	6.3	-2.5	2.2	-1.9	1.9	1.6	-1.5	1.5
Conditioned locomotion	2.5	3.7	5.3	-1.5	0.5	-2.3	2.3	1.8	-2.1	2.1
Patch foraging indifference point 0 sec	0.1	0.3	0.5	-0.6	-0.6	-0.5	0.5	0.7	-0.5	0.5
Patch foraging indifference point AUC	0.4	0.9	3.0	-1.5	1.7	-0.4	0.4	0.4	-0.6	0.6
Delay disc. indifference point, 0s delay	0.5	0.6	1.0	-0.2	-0.2	-0.8	0.8	1.0	-0.9	0.9
Delay disc. indifference point, 16s delay	1.1	1.6	5.8	-2.4	2.0	-0.2	0.2	0.5	-0.6	0.6
Delay disc. indifference point, 2s delay	1.6	1.8	6.1	-2.3	2.5	-0.6	0.6	0.6	-0.5	0.5
Delay disc. indifference point, 24s delay	0.2	0.4	0.9	-1.0	0.5	-0.5	0.5	0.5	-0.6	0.6
Delay disc. indifference point, 4s delay	0.9	0.9	2.6	-1.6	1.1	-0.6	0.6	0.8	-0.7	0.7
Delay disc. indifference point, 8s delay	0.7	1.2	4.0	-2.0	1.9	-0.2	0.2	0.3	-0.4	0.4
Indifference point function ln k	0.6	1.7	4.9	2.2	-1.9	0.7	-0.7	-0.7	0.9	-0.9
Indifference point function log k	0.6	1.7	4.9	2.2	-1.9	0.7	-0.7	-0.7	0.9	-0.9
Patch foraging total patch changes 0 sec	0.1	0.2	0.9	-0.9	-0.1	-0.3	0.3	0.4	-0.2	0.2
Patch foraging total patch changes 12 sec	0.8	1.1	1.9	-0.7	0.1	-1.0	1.0	1.4	-1.3	1.3
Patch foraging total patch changes 18 sec	1.1	2.6	3.6	-1.7	0.3	-1.9	1.9	1.9	-1.5	1.5
Patch foraging total patch changes 24 sec	0.1	0.4	1.3	-0.9	1.2	-0.4	0.4	0.6	-0.1	0.1
Patch foraging total patch changes 6 sec	0.9	1.6	3.1	-1.8	0.6	-1.2	1.2	1.3	-1.2	1.2
Patch foraging time to switch 0 sec	0.1	0.5	1.1	-0.2	-0.6	-0.5	0.5	0.7	-1.0	1.0
Patch foraging water rate 0 sec	0.0	0.1	0.2	-0.2	-0.5	-0.4	0.4	0.1	0.2	-0.2
Patch foraging water rate 12 sec	0.1	0.6	1.3	0.3	-0.1	0.7	-0.7	-0.7	1.1	-1.1
Patch foraging water rate 18 sec	0.0	0.1	0.3	-0.1	-0.6	0.2	-0.2	0.1	0.0	-0.0
Patch foraging water rate 24 sec	0.7	1.0	3.6	1.6	-1.9	0.5	-0.5	-0.2	0.4	-0.4
Patch foraging water rate 6 sec	0.8	1.2	1.7	0.5	0.3	1.3	-1.3	-1.2	1.2	-1.2
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.2	-0.5	0.3	0.7	-0.7	-1.1	0.8	-0.8
Distance traveled before self-admin	0.5	1.0	2.5	-1.6	0.8	-0.8	0.8	0.7	-1.1	1.1
Distance traveled after self-admin	1.5	2.6	3.8	-1.3	-0.6	-1.6	1.6	1.8	-1.9	1.9
Extensor digitorum longus weight	0.4	1.5	2.9	-1.7	1.6	0.7	-0.7	-1.2	1.2	-1.2
Bone: elastic displacement	0.2	0.2	1.2	0.4	-1.1	-0.2	0.2	0.1	-0.2	0.2
Bone: elastic work	2.3	3.0	4.9	0.4	-2.2	-1.8	1.8	1.7	-1.8	1.8
Bone: endosteal estimation	1.1	2.6	4.7	0.5	-2.2	-1.6	1.6	1.7	-1.6	1.6
Bone: endosteal perimeter	0.8	1.9	5.5	1.2	-2.3	-1.2	1.2	1.2	-1.0	1.0
Epididymis fat weight	0.6	2.8	12.3	3.5	-2.7	-0.4	0.4	0.2	-0.0	0.0
Delta time in closed arm before/after self-admin	0.6	0.5	1.0	-0.7	1.0	-0.7	0.7	0.5	-0.7	0.7
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.5	-0.1	0.1	-0.1	0.0	-0.2	0.2
Diff in mean of infusions in LGA sessions	0.2	0.4	0.9	0.1	-0.3	-0.9	0.9	0.7	-0.6	0.6
Delay discount exponential model param	1.1	1.5	5.1	2.3	-2.0	0.4	-0.4	-0.6	0.6	-0.6
Extinction: sum of active levers before priming	0.7	1.1	1.6	-0.7	0.5	-1.3	1.3	1.1	-1.1	1.1
Active lever presses in extinction session 6	0.2	0.2	0.5	0.0	-0.2	-0.7	0.7	0.5	-0.4	0.4
Bone: final force	1.5	2.5	3.5	-0.2	-1.1	-1.8	1.8	1.8	-1.9	1.9
Bone: final moment	1.8	3.0	4.2	-0.2	-1.2	-1.9	1.9	1.9	-2.1	2.1
Food consumed during 24 hour testing period	0.6	1.3	1.9	0.2	-0.4	-1.3	1.3	1.4	-1.2	1.2
Glucose	0.2	0.3	0.5	0.0	-0.3	-0.7	0.7	0.7	-0.5	0.5
Heart weight	1.7	2.7	8.9	1.5	-3.0	-1.3	1.3	1.2	-1.1	1.1
Delay discount hyperbolic model param	1.2	1.5	5.1	2.3	-2.2	0.3	-0.3	-0.5	0.5	-0.5
Intermittent access intake day 1-15 change	0.0	0.3	0.6	-0.2	0.4	0.5	-0.5	-0.8	0.4	-0.4
Intermittent access intake escalation	0.1	0.5	0.9	-0.3	0.6	0.9	-0.9	-1.0	0.7	-0.7
Intermittent access intake escalation 2	0.2	0.4	0.6	-0.3	0.4	0.6	-0.6	-0.8	0.7	-0.7
Intermitt. access day 1 inactive lever presses	0.2	2.2	4.1	-0.1	-1.1	-1.4	1.4	2.0	-1.7	1.7
Intermitt. access day 15 inactive lever presses	0.2	1.0	1.2	-1.1	0.3	-1.1	1.1	1.0	-1.1	1.1
Intermitt. access escalation Index	0.3	1.0	1.4	0.0	1.2	1.0	-1.0	-1.1	1.1	-1.1
Intermittent access day 1 total infusions	1.2	3.7	4.7	-1.8	1.1	-2.2	2.2	2.2	-2.0	2.0
Intermittent access day 15 total infusions	0.5	1.2	3.2	-1.8	1.5	-0.7	0.7	0.7	-0.8	0.8
Intermittent access terminal intake (last 3 days)	0.7	1.3	3.1	-1.8	1.3	-1.0	1.0	0.7	-0.9	0.9
Intermittent access total infusions	3.7	4.4	5.5	-2.4	1.5	-2.3	2.3	2.0	-2.1	2.1
Intermittent access day 1 locomotion	1.4	2.6	3.8	-1.7	0.9	-1.9	1.9	1.4	-1.5	1.5
Intermittent access day 15 total locomotion	0.5	2.0	3.7	-0.8	0.5	-1.9	1.9	1.3	-1.4	1.4
Intermittent access total locomotion	2.8	3.3	5.9	-1.0	0.4	-2.4	2.4	1.7	-2.0	2.0
Intermittent access standard deviation	1.0	5.0	9.4	-1.3	-0.4	-2.1	2.1	2.3	-3.1	3.1
Left kidney weight	1.7	13.4	34.9	4.7	-5.9	-2.8	2.8	2.6	-2.6	2.6
Right kidney weight	2.4	16.8	44.1	5.1	-6.6	-3.1	3.1	2.9	-3.1	3.1
Cocaine induced anxiety	0.2	0.4	1.2	1.1	-0.7	-0.9	0.9	0.0	0.0	-0.0
Post-drug Anxiety	0.7	0.8	1.8	1.3	-0.8	0.4	-0.4	-0.9	1.0	-1.0
Baseline Anxiety	0.4	0.7	1.0	-0.7	0.7	1.0	-1.0	-0.6	0.8	-0.8
Tail length	0.1	0.6	0.8	0.6	-0.9	0.7	-0.7	-0.8	0.9	-0.9
Length with tail	0.4	1.6	6.6	2.2	-2.6	0.0	-0.0	-0.1	0.1	-0.1
Length without tail	0.8	4.0	11.0	2.3	-3.3	-1.6	1.6	1.4	-1.5	1.5
Times rat made contact with spout	0.2	0.2	1.2	-0.4	1.1	-0.4	0.4	-0.1	0.2	-0.2
Lifetime Intake	4.7	5.8	7.1	-2.3	1.5	-2.7	2.7	2.5	-2.5	2.5
Liver weight, left	0.7	1.2	3.7	1.9	-0.3	0.9	-0.9	-0.9	0.9	-0.9
Liver weight, right	3.3	5.8	15.8	4.0	-1.9	2.0	-2.0	-2.2	2.0	-2.0
Locomotor activity	0.4	0.7	2.1	1.5	-1.4	-0.3	0.3	0.3	-0.3	0.3
Locomotor testing distance	0.1	0.2	0.3	0.1	0.5	0.5	-0.5	-0.5	0.4	-0.4
Locomotor testing rearing	0.1	0.4	1.1	1.1	-0.8	-0.7	0.7	0.4	-0.3	0.3
Locomotion in novel chamber	3.1	4.2	5.7	-0.0	1.4	2.4	-2.4	-2.2	2.4	-2.4
Locomotion in novel chamber post-restriction	0.5	1.4	3.0	-0.8	1.7	1.2	-1.2	-0.9	1.1	-1.1
Fecal boli incidents, locomotor time 1	0.9	2.2	3.2	-1.3	-0.2	-1.5	1.5	1.6	-1.8	1.8
Change in fecal boli incidents, locomotor task	1.1	1.1	3.0	1.7	-0.5	1.0	-1.0	-1.0	0.9	-0.9
Time >=10cm from walls, locomotor time 1	1.2	1.4	1.7	0.3	-1.3	-1.3	1.3	1.3	-1.3	1.3
Bouts of movement, locomotor time 1	0.1	0.2	1.0	1.0	-0.3	-0.3	0.3	0.2	-0.1	0.1
Total resting periods, locomotor time 1	0.3	0.4	0.6	0.5	-0.4	-0.7	0.7	0.7	-0.5	0.5
Rest time, locomotor task time 1	0.9	1.4	2.2	0.5	-0.8	-1.5	1.5	1.3	-1.2	1.2
Distance moved, locomotor task time 1	0.4	1.0	1.3	0.8	-0.5	1.1	-1.1	-1.1	1.1	-1.1
Vertical activity count, locomotor time 1	0.0	0.2	0.4	0.6	-0.5	0.5	-0.5	-0.6	0.4	-0.4
Time >=10cm from walls, locomotor time 2	0.1	0.3	1.5	0.3	-1.2	-0.3	0.3	0.3	-0.4	0.4
Bouts of movement, locomotor time 2	0.1	0.5	1.5	0.5	1.2	0.3	-0.3	-0.7	0.7	-0.7
Total resting periods, locomotor time 2	0.1	0.3	1.9	0.0	1.4	-0.1	0.1	-0.3	0.3	-0.3
Rest time, locomotor task time 2	0.3	0.6	0.8	-0.5	0.4	-0.8	0.8	0.9	-0.8	0.8
Distance moved, locomotor task time 2	0.4	0.6	1.2	0.9	-1.1	0.7	-0.7	-0.5	0.6	-0.6
Vertical activity count, locomotor time 2	0.1	0.2	1.0	0.8	-1.0	0.0	-0.0	-0.1	-0.1	0.1
Light reinforcement 1	0.0	0.2	0.4	-0.5	-0.1	-0.6	0.6	0.3	0.2	-0.2
Light reinforcement 2	0.3	0.7	1.8	1.3	-0.5	0.6	-0.6	-1.0	0.8	-0.8
Bone: marrow area	1.1	2.7	4.9	0.5	-2.2	-1.6	1.6	1.8	-1.7	1.7
Bone: maximum diameter	1.8	3.6	6.3	1.0	-2.5	-2.0	2.0	2.1	-1.7	1.7
Bone: maximum force	2.3	4.5	6.1	-0.4	-1.2	-2.5	2.5	2.3	-2.4	2.4
Bone: maximum moment	2.6	4.9	6.7	-0.3	-1.4	-2.5	2.5	2.5	-2.6	2.6
Mean time between licks in bursts	0.1	0.5	1.1	-1.1	0.3	0.7	-0.7	-0.4	0.6	-0.6
Mean num. licks in bursts	0.1	0.3	1.3	1.1	-0.5	-0.4	0.4	0.1	-0.4	0.4
Cd content in liver	0.2	0.3	0.5	0.6	0.2	0.4	-0.4	-0.2	0.7	-0.7
Co content in liver	0.5	0.6	1.8	-1.3	0.9	-0.6	0.6	0.7	-0.5	0.5
Cu content in liver	2.0	2.4	6.8	-2.6	2.3	1.0	-1.0	-1.0	0.9	-0.9
Fe content in liver	1.9	2.3	8.8	1.0	-3.0	-1.1	1.1	1.2	-1.1	1.1
K content in liver	0.1	0.1	0.2	-0.5	0.4	0.3	-0.3	-0.4	0.1	-0.1
Mg content in liver	0.1	0.1	0.4	-0.6	0.2	-0.1	0.1	-0.1	-0.3	0.3
Mn content in liver	0.5	0.6	0.9	0.5	0.8	1.0	-1.0	-0.8	0.5	-0.5
Na content in liver	0.1	0.1	0.4	-0.6	-0.0	0.2	-0.2	-0.4	0.1	-0.1
Rb content in liver	0.7	0.8	1.2	-1.0	0.2	-1.1	1.1	0.8	-0.9	0.9
Se content in liver	2.3	2.8	4.0	0.2	0.7	2.0	-2.0	-1.9	1.9	-1.9
Sr content in liver	3.2	2.8	5.8	-1.3	2.4	1.5	-1.5	-1.6	1.5	-1.5
Zn content in liver	0.1	0.1	0.4	-0.2	0.5	0.3	-0.3	-0.6	0.3	-0.3
Bone: minimum diameter	0.7	1.4	2.6	0.2	-0.8	-1.4	1.4	1.6	-1.2	1.2
Time in familiar zone, hab. session 1	0.2	0.3	0.7	-0.4	-0.0	-0.5	0.5	0.9	-0.4	0.4
Time in novel zone, hab. session 1	0.3	0.4	1.2	1.0	-1.1	0.1	-0.1	-0.6	0.2	-0.2
Total zone transitions, hab. session 1	2.6	3.6	4.9	-1.2	2.2	2.2	-2.2	-1.7	1.8	-1.8
Total locomotion distance, hab. session 1	1.7	2.4	3.5	-0.1	1.4	1.9	-1.9	-1.3	1.8	-1.8
Locomotion velocity, hab. session 1	1.3	1.9	2.5	-0.6	1.6	1.6	-1.6	-1.1	1.4	-1.4
Time in familiar zone, hab. session 2	1.5	1.7	2.6	0.5	0.4	1.6	-1.6	-1.4	1.4	-1.4
Time in novel zone, hab. session 2	1.5	1.6	2.5	-0.6	-0.1	-1.6	1.6	1.5	-1.4	1.4
Total zone transitions, hab. session 2	0.9	1.1	3.9	-2.0	1.1	-0.6	0.6	0.9	-0.7	0.7
Total locomotion distance, hab. session 2	1.0	1.3	3.3	-1.8	0.6	-0.8	0.8	1.3	-1.1	1.1
Locomotion velocity, hab. session 2	1.1	1.5	4.5	-2.1	0.8	-0.8	0.8	1.3	-1.1	1.1
Novel to familiar place preference ratio	0.6	0.8	2.3	1.5	-1.3	0.5	-0.5	-0.6	0.7	-0.7
Novelty place preference	1.1	1.4	3.7	1.9	-1.3	0.8	-0.8	-0.9	1.0	-1.0
Time in novel zone, NPP test	1.3	1.6	4.3	2.1	-1.4	0.9	-0.9	-1.0	1.1	-1.1
Total zone transitions, NPP test	1.2	1.7	4.5	-1.9	2.1	1.0	-1.0	-0.7	0.8	-0.8
Total locomotion distance, NPP test	0.3	0.4	2.0	-1.4	0.9	0.1	-0.1	0.4	-0.2	0.2
Locomotion velocity, NPP test	0.4	0.6	2.5	-1.6	1.2	0.3	-0.3	0.2	-0.0	0.0
Intraocular pressure	0.2	0.4	0.7	0.8	-0.8	-0.6	0.6	0.6	-0.3	0.3
Delta distance traveled before/after self-admin	0.9	0.9	2.8	0.9	-1.7	-0.7	0.7	0.8	-0.8	0.8
Delta ambulatory time before/after self-admin	0.7	1.2	2.8	0.5	-1.7	-1.0	1.0	1.1	-1.0	1.0
Parametrial fat weight	1.1	2.6	3.4	1.8	-0.7	1.8	-1.8	-1.7	1.5	-1.5
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.3	-0.3	-0.1	0.1	-0.1	-0.1	0.1
Pavlov. Cond. magazine entry latency	0.5	0.7	1.9	-1.4	1.1	-0.5	0.5	0.6	-0.5	0.5
Pavlov. Cond. change in total contacts	1.2	1.3	3.5	-1.9	1.5	-0.8	0.8	1.0	-0.8	0.8
Pavlov. Cond. index score	0.4	0.6	0.8	-0.9	0.6	-0.7	0.7	0.8	-0.7	0.7
Pavlov. Cond. latency score	0.2	0.3	0.5	-0.7	0.4	-0.4	0.4	0.6	-0.5	0.5
Pavlov. Cond. lever contacts	0.2	0.2	0.8	-0.9	0.7	-0.1	0.1	0.3	-0.2	0.2
Pavlov. Cond. magazine entry number	0.6	0.7	1.9	1.4	-1.4	0.4	-0.4	-0.5	0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.2	1.1	-1.0	0.4	0.0	-0.0	0.3	0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	-0.9	0.8	-0.5	0.5	0.6	-0.5	0.5
Pavlov. Cond. response bias	0.5	0.6	1.5	-1.2	1.1	-0.5	0.5	0.6	-0.6	0.6
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.6	0.5	0.7	-0.7	-0.3	0.5	-0.5
Pavlov. Cond. magazine entry latency	1.1	1.6	4.7	-2.2	1.0	-1.1	1.1	1.0	-1.0	1.0
Pavlov. Cond. change in total contacts	2.2	5.3	7.3	-0.8	-1.9	-2.7	2.7	2.4	-2.5	2.5
Pavlov. Cond. index score	0.7	1.1	1.9	-1.4	-0.0	-1.1	1.1	0.9	-1.1	1.1
Pavlov. Cond. latency score	0.8	1.2	2.5	-1.6	0.1	-1.2	1.2	0.9	-1.2	1.2
Pavlov. Cond. lever contacts	0.2	0.2	0.3	-0.6	-0.5	-0.6	0.6	0.2	-0.4	0.4
Pavlov. Cond. magazine entry number	0.5	0.6	1.4	1.2	-0.1	0.8	-0.8	-0.5	0.8	-0.8
Pavlov. Cond. intertrial magazine entries	0.2	0.4	0.8	0.5	-0.1	-0.6	0.6	0.9	-0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	1.8	-1.3	-0.1	-1.0	1.0	0.7	-1.0	1.0
Pavlov. Cond. response bias	0.7	1.0	1.4	-1.1	-0.3	-1.2	1.2	0.8	-1.0	1.0
Time in closed arm before self-admin	0.2	0.3	2.1	-1.4	0.3	0.0	-0.0	-0.1	0.0	-0.0
Time in closed arm after self-admin	0.3	0.3	0.7	-0.1	0.0	-0.8	0.8	0.5	-0.5	0.5
Time in open arm before self-admin	0.4	0.5	0.7	0.7	0.0	0.8	-0.8	-0.8	0.7	-0.7
Time in open arm after self-admin	0.8	0.9	1.7	0.2	0.4	1.2	-1.2	-1.3	0.9	-0.9
Bone: periosteal estimation	1.1	2.7	3.7	0.5	-1.9	-1.7	1.7	1.9	-1.7	1.7
Bone: periosteal perimeter	1.5	3.0	6.9	1.4	-2.6	-1.5	1.5	1.7	-1.4	1.4
Bone: post-yield work	1.1	1.9	3.6	-1.2	0.2	-1.9	1.9	1.3	-1.3	1.3
Progressive ratio test 1 active lever presses	2.0	3.5	4.6	-1.9	1.1	-2.1	2.1	1.8	-1.9	1.9
Progressive ratio test 1 breakpoint	1.8	3.1	3.8	-1.9	1.1	-1.9	1.9	1.6	-1.8	1.8
Progressive ratio test 1 inactive lever presses	2.0	5.2	7.2	-2.5	0.9	-2.7	2.7	2.7	-2.0	2.0
Progressive ratio test 2 active lever presses	2.0	2.8	3.4	-1.6	1.8	-1.7	1.7	1.7	-1.6	1.6
Progressive ratio test 2 breakpoint	2.2	2.8	3.7	-1.7	1.9	-1.6	1.6	1.6	-1.6	1.6
Progressive ratio test 2 inactive lever presses	0.5	1.7	5.6	-1.9	2.4	-0.8	0.8	0.7	-0.6	0.6
Incentive Sensitization - Responses	0.1	0.3	1.8	-0.4	1.3	0.1	-0.1	0.3	-0.1	0.1
Incentive Sensitization - Breakpoint	0.1	0.3	1.6	-0.3	1.3	-0.0	0.0	0.4	-0.2	0.2
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.0	-0.2	-0.1	0.1	0.2	-0.1	0.1
Progressive ratio	0.1	0.4	0.5	-0.7	-0.3	-0.7	0.7	0.4	-0.7	0.7
Food seeking constrained by brief footshock	0.2	0.3	0.8	-0.2	0.2	-0.9	0.9	0.2	-0.4	0.4
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	0.2	0.2	-0.4	0.4	0.4	-0.2	0.2
Retroperitoneal fat weight	1.0	4.7	19.8	4.5	-3.5	-0.2	0.2	0.2	-0.2	0.2
Reaction time number correct	0.8	2.8	4.5	0.8	1.2	2.1	-2.1	-1.8	1.6	-1.6
Reaction time mean minus median	0.0	0.0	0.1	-0.3	-0.3	-0.1	0.1	0.2	-0.2	0.2
Reaction time mean minus median AUC	0.0	0.1	0.4	0.6	-0.7	-0.0	0.0	0.1	-0.1	0.1
Reaction time num false alarms	0.1	0.2	0.2	0.3	-0.1	0.4	-0.4	-0.5	0.5	-0.5
Reaction time num false alarms AUC	0.1	0.3	0.4	0.3	0.0	0.6	-0.6	-0.7	0.6	-0.6
Reaction time trials correct on left	0.8	2.8	4.5	0.8	1.2	2.1	-2.1	-1.8	1.6	-1.6
Reaction time trials on left	0.8	2.9	4.6	0.7	1.3	2.1	-2.1	-1.8	1.7	-1.7
Reaction time mean	0.0	0.1	0.6	-0.1	-0.8	0.0	-0.0	-0.0	-0.3	0.3
Reaction time mean AUC	0.0	0.1	0.3	-0.0	-0.6	0.1	-0.1	-0.1	-0.2	0.2
Median of all reaction times	0.1	0.1	0.5	-0.1	-0.7	0.1	-0.1	-0.1	-0.3	0.3
Reaction time omissions	0.3	0.5	2.1	-1.0	1.4	0.6	-0.6	-0.1	0.0	-0.0
Reaction time false alarm rate	0.0	0.0	0.2	-0.0	-0.4	-0.2	0.2	0.0	0.0	-0.0
Reaction time premature initiation rate	2.0	3.2	6.0	-0.7	-0.7	-2.0	2.0	2.4	-1.9	1.9
Reaction time premature initiations	0.3	0.9	2.3	-0.1	-0.2	-0.9	0.9	1.5	-1.0	1.0
Std. dev. reaction times	0.0	0.1	0.7	0.4	-0.8	-0.0	0.0	0.1	-0.2	0.2
Reaction time trials completed	0.8	2.9	4.6	0.7	1.3	2.1	-2.1	-1.8	1.7	-1.7
Reaction time trials AUC	0.7	2.3	3.8	0.9	1.0	2.0	-2.0	-1.6	1.5	-1.5
Run reversals in cocaine runway, females	0.6	0.7	1.5	0.9	-0.4	0.5	-0.5	-0.4	1.2	-1.2
Run reversals in cocaine runway, males	0.1	0.1	0.3	-0.0	-0.2	-0.3	0.3	0.3	-0.5	0.5
Latency to leave start box in cocaine runway	0.3	0.4	0.8	0.8	-0.9	0.7	-0.7	-0.3	0.1	-0.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.3	-0.5	0.4	-0.4	-0.0	-0.1	0.1
Latency to leave start box in cocaine runway, M	0.8	0.8	3.2	1.8	-0.8	0.7	-0.7	-0.6	0.3	-0.3
Std. dev. time between licks in bursts	0.2	0.3	1.4	-1.2	-0.2	-0.1	0.1	0.4	-0.6	0.6
Total sessions with >9 infusions	4.5	5.6	8.8	-1.0	-0.2	-3.0	3.0	2.5	-2.7	2.7
Short access day 1 total inactive lever presses	4.0	8.0	10.2	-2.2	-1.2	-3.2	3.2	3.1	-3.1	3.1
Short access day 10 total inactive lever presses	0.1	0.7	1.6	0.9	-1.3	-0.7	0.7	0.8	-0.6	0.6
Short access day 1 total infusions	1.6	3.1	4.2	-1.2	-0.3	-2.0	2.0	1.9	-2.0	2.0
Short access day 10 total infusions	2.1	3.5	5.3	-0.9	-0.1	-2.3	2.3	2.2	-2.1	2.1
Short access total infusions	4.3	6.1	9.0	-1.6	0.3	-3.0	3.0	2.7	-2.7	2.7
Short access day 1 locomotion	1.2	2.0	3.5	-1.0	-0.6	-1.4	1.4	1.3	-1.9	1.9
Short access day 10 total locomotion	0.6	2.5	4.2	-1.2	0.1	-1.4	1.4	1.8	-2.1	2.1
Short access total locomotion	2.1	3.2	4.9	-1.1	-0.2	-2.0	2.0	1.9	-2.2	2.2
One hour access (0.3 mA shock)	2.2	2.6	8.3	-2.6	2.9	-0.9	0.9	0.6	-0.8	0.8
Compulsive drug intake	0.3	0.4	1.8	-0.4	1.3	0.6	-0.6	-0.4	0.2	-0.2
One hour access (shock baseline)	0.3	0.9	2.2	-1.5	1.2	-0.9	0.9	0.6	-0.5	0.5
Social response proportion	0.5	0.6	1.2	-0.6	-1.1	-0.6	0.6	0.5	-0.9	0.9
Social responses	0.5	0.7	1.9	-1.4	0.4	-0.6	0.6	0.9	-0.9	0.9
Social time	1.1	1.7	6.4	-2.5	1.4	-0.5	0.5	0.9	-1.0	1.0
Soleus weight	0.3	0.9	1.3	-1.0	1.2	-0.9	0.9	1.0	-0.9	0.9
Bone: stiffness	1.5	2.8	3.6	-0.1	-1.4	-1.9	1.9	1.7	-1.9	1.9
Tibialis anterior weight	0.8	2.9	10.5	-3.0	3.2	0.3	-0.3	-0.4	0.6	-0.6
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.4	-0.1	0.0	-0.6	0.6	0.7	-0.1	0.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.5	0.0	-0.7	0.3	-0.3	-0.1	-0.0	0.0
Time to tail flick, test, before self-admin	0.2	0.3	1.1	0.1	1.1	0.3	-0.3	-0.3	0.5	-0.5
Time to tail flick, test, after self-admin	0.4	0.4	1.2	-0.1	0.3	0.6	-0.6	-1.1	0.7	-0.7
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.0	-0.6	-0.7	-0.5	0.5	0.5	-1.0	1.0
Delta time to tail flick, test, before/after SA	0.8	1.0	2.1	-0.5	0.4	1.0	-1.0	-1.4	1.2	-1.2
Tibia length	0.5	1.4	2.1	0.5	-1.0	-1.2	1.2	1.5	-1.3	1.3
Ambulatory time before self-admin	0.2	0.5	1.8	-1.3	1.1	-0.2	0.2	0.1	-0.5	0.5
Ambulatory time after self-admin	0.5	0.8	2.2	-1.5	-0.1	-0.7	0.7	0.7	-1.1	1.1
Bone: tissue strength	0.1	0.2	0.6	0.8	-0.6	-0.1	0.1	-0.1	-0.2	0.2
Total heroin consumption	0.6	0.7	1.0	-0.9	1.0	-0.9	0.9	0.7	-0.8	0.8
Bone: trabecular number	0.2	0.4	0.6	0.6	-0.1	0.7	-0.7	-0.6	0.8	-0.8
Bone: trabecular spacing	1.8	2.6	3.9	-0.1	-0.7	-2.0	2.0	1.9	-1.8	1.8
Bone: trabecular thickness	0.8	1.1	1.9	0.4	0.3	1.4	-1.4	-1.2	1.1	-1.1
Bone: trabecular tissue density	0.4	0.7	1.0	-0.7	0.1	0.9	-0.9	-1.0	0.9	-0.9
Water consumed over 24 hours	0.2	0.4	0.5	-0.5	0.5	-0.7	0.7	0.4	-0.7	0.7
Number of responses in last shaping day	3.3	4.3	7.5	-2.7	1.2	-1.9	1.9	2.0	-2.2	2.2