LOC134479863

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	LOC134479863	0.04	0.02	1.9e-03	0.02	0.02	0.02	0.02	2.1e-03	1.3e-03	2.4e-03	2.0e-03
2	NAcc	mRNA stability	LOC134479863	0.1	0.04	1.2e-07	0.05	0.06	0.05	0.06	6.4e-08	6.4e-09	3.9e-08	2.6e-09
3	pVTA	mRNA stability	LOC134479863	0.07	0.04	6.6e-04	0.04	0.03	0.03	0.03	1.9e-04	1.4e-03	2.1e-03	1.5e-03
4	BLA	gene expression	LOC134479863	0.11	0.06	1.4e-03	0.01	0.05	0.06	0	1.1e-01	1.6e-03	3.5e-04	3.3e-01
5	Adipose	gene expression	LOC134479863	0.37	0.09	0.0e+00	0.19	0.19	0.18	0.19	6.8e-21	1.5e-20	6.4e-20	2.9e-20
6	PL	gene expression	LOC134479863	0.11	0.04	1.1e-06	0.09	0.06	0.09	0.08	7.6e-10	4.8e-07	7.6e-10	3.0e-09
7	Adipose	mRNA stability	LOC134479863	0.23	0.07	1.4e-15	0.14	0.12	0.14	0.14	2.6e-15	2.9e-13	9.8e-15	6.2e-15
8	Liver	gene expression	LOC134479863	0.54	0.09	0.0e+00	0.28	0.3	0.32	0.31	2.0e-31	2.7e-33	2.1e-36	1.4e-34
9	Liver	mRNA stability	LOC134479863	0.2	0.07	3.6e-13	0.11	0.09	0.12	0.12	3.2e-12	1.8e-10	3.3e-13	9.1e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.1	0.2	0.5	-0.4	0.1	0.3	-0.5	0.5	-0.5	0.6	0.4	0.7
Area under the delay curve	0.5	0.6	1.1	-0.1	0.1	-0.8	-0.9	-0.9	0.8	-1.0	-0.7	-0.8
BMI with tail	3.6	12.4	30.3	3.6	0.3	-0.1	2.0	-4.1	4.1	-4.3	-5.5	-3.6
BMI without tail	2.1	6.4	23.8	4.9	3.0	2.7	0.9	-1.5	1.5	-1.7	-3.0	-0.3
Body weight	5.6	24.3	90.7	9.5	5.6	4.2	3.1	-3.9	3.8	-3.9	-5.0	-0.5
Weight adjusted by age	0.4	0.6	1.0	-0.7	-0.8	-0.4	0.8	-0.9	0.9	-1.0	-0.7	-0.6
Bone surface	0.2	0.3	1.4	1.2	0.6	0.3	0.2	-0.4	0.4	-0.3	-0.6	-0.1
Bone volume	0.1	0.2	0.7	0.8	0.3	0.3	0.3	-0.5	0.5	-0.3	-0.7	-0.1
Breakpoint value in progressive ratio session	1.3	1.5	4.1	-1.7	-2.0	-2.0	0.3	-0.5	0.5	-0.6	-0.4	-1.2
Number of licking bursts	0.8	1.3	2.1	1.0	-0.3	-0.5	1.4	-1.2	1.2	-1.2	-1.5	-1.2
Context. condit. distance diff. score	0.8	1.0	2.8	0.8	1.7	1.6	-0.8	0.8	-0.8	0.7	0.1	0.9
Locomotion velocity, session 1	1.2	1.3	3.6	-1.8	-1.9	-1.4	0.6	-0.7	0.7	-0.7	-0.7	-0.9
Locomotion distance, session 1	0.8	1.0	2.8	-0.2	-1.1	-1.7	1.3	-0.9	0.9	-0.9	0.1	-0.9
Locomotion velocity, session 2	1.8	2.1	3.2	-0.7	1.1	1.1	-1.1	1.7	-1.7	1.6	1.6	1.8
Locomotion distance, session 2	0.7	1.0	2.6	0.8	-0.5	-1.2	1.6	-1.1	1.1	-1.1	-0.1	-0.7
Locomotion velocity, session 3	1.7	2.0	3.5	-1.0	0.7	0.6	-1.0	1.7	-1.7	1.6	1.9	1.8
Locomotion distance, session 3	0.2	0.2	0.4	0.6	0.6	-0.2	0.6	-0.2	0.2	-0.3	0.5	0.1
Stereotopy head waving bouts, day 3	1.6	1.9	4.2	-1.1	-0.1	0.1	-0.4	1.8	-1.8	1.8	2.0	1.5
Stereotopy head waving duration, day 3	1.3	1.5	2.6	-1.2	-0.1	0.6	-0.9	1.6	-1.6	1.6	1.3	1.4
Locomotion velocity, session 7	0.3	0.3	1.1	-0.2	-0.3	-1.1	1.0	-0.3	0.3	-0.3	0.5	-0.2
Locomotion distance, session 7	0.1	0.2	0.9	-0.3	-0.2	-0.9	0.2	-0.0	0.0	-0.0	0.8	0.0
Stereotopy head waving bouts, day 7	0.4	0.5	0.9	-1.0	-0.2	0.3	0.2	0.7	-0.7	0.7	0.9	0.9
Stereotopy head waving duration, day 7	0.2	0.2	0.8	-0.9	-0.8	-0.2	0.5	-0.1	0.1	-0.1	0.1	0.0
Locomotion velocity, session 8	0.9	1.1	3.5	0.2	1.1	1.9	-1.0	0.9	-0.9	0.9	0.4	1.2
Locomotion distance, session 8	0.8	1.1	4.9	2.2	1.5	0.4	1.1	-0.6	0.6	-0.7	-0.5	0.1
Degree of sensitization distance	0.1	0.2	0.8	-0.5	-0.4	-0.1	-0.9	0.2	-0.2	0.2	-0.1	-0.0
Degree of sensitization stereotypy	0.3	0.3	1.1	-1.1	-0.1	0.4	-0.1	0.6	-0.6	0.5	0.6	0.7
Conditioned locomotion	0.6	0.7	1.2	-0.1	0.7	0.8	-0.6	1.1	-1.1	1.0	0.4	1.0
Cocaine response after cond. corrected	0.6	0.7	1.3	1.1	1.0	1.1	-1.1	-0.3	0.2	-0.3	-1.2	-0.1
Cocaine response after cond. not corrected	0.6	0.7	1.7	1.2	0.7	0.6	-0.8	-0.6	0.5	-0.7	-1.3	-0.5
Cocaine response before conditioning	0.5	0.5	1.3	-0.1	-0.9	-1.1	0.6	-0.7	0.7	-0.7	-0.3	-0.9
Saline control response	0.2	0.3	0.6	0.8	0.6	0.8	0.6	0.3	-0.2	0.4	0.4	0.7
Bone: connectivity density	0.7	1.1	1.8	-0.6	0.5	0.9	-1.0	1.2	-1.2	1.4	1.1	1.3
Bone: cortical apparent density	0.2	0.2	0.4	0.2	0.4	0.1	0.7	0.4	-0.4	0.3	0.7	0.6
Bone: cortical area	0.8	1.2	2.6	1.6	0.2	-0.3	0.5	-1.3	1.3	-1.2	-1.4	-0.7
Bone: cortical porosity	1.0	1.1	1.9	0.2	0.9	1.1	-1.3	1.1	-1.1	1.1	1.0	1.4
Bone: cortical porosity	0.2	0.2	0.7	0.3	0.5	0.5	-0.9	0.3	-0.3	0.4	0.3	0.7
Bone: cortical thickness	0.1	0.2	0.6	0.8	0.1	-0.3	-0.1	-0.6	0.6	-0.5	-0.4	-0.0
Bone: cortical thickness	0.2	0.2	0.9	-0.7	-0.6	-0.1	-0.9	-0.0	0.0	-0.1	-0.4	-0.2
Bone: cortical tissue density	0.2	0.3	0.5	0.2	0.5	0.2	0.6	0.5	-0.5	0.4	0.7	0.7
Condit. Reinf. active minus inactive responses	3.2	3.6	8.0	-1.9	-2.8	-2.8	1.2	-1.5	1.5	-1.3	-0.9	-2.1
Condit. Reinf. active-inactive response ratio	2.9	3.1	5.9	-1.5	-2.4	-2.4	0.9	-1.6	1.6	-1.5	-1.3	-2.1
Condit. Reinf. active responses	3.2	4.0	10.4	-2.4	-3.2	-2.8	1.0	-1.5	1.5	-1.2	-0.9	-2.1
Condit. Reinf. inactive responses	0.6	0.8	3.0	-1.7	-1.6	-1.0	-0.0	-0.2	0.2	0.0	0.0	-0.5
Incentive salience index mean	4.4	5.4	10.3	-1.3	-3.2	-3.1	2.3	-2.2	2.2	-2.0	-1.4	-2.4
Condit. Reinf. lever presses	2.3	3.2	6.9	-0.4	-2.3	-2.1	2.6	-1.8	1.8	-1.6	-0.8	-1.6
Condit. Reinf. active minus inactive responses	1.1	1.4	4.4	-1.3	-2.1	-1.7	1.5	-0.3	0.3	-0.3	0.8	-0.6
Condit. Reinf. active-inactive response ratio	0.3	0.4	1.2	-0.9	-0.9	-0.5	0.3	0.3	-0.4	0.3	1.1	0.2
Condit. Reinf. active responses	0.9	1.3	3.7	-1.0	-1.9	-1.6	1.6	-0.7	0.6	-0.6	0.4	-0.9
Condit. Reinf. inactive responses	0.6	0.8	1.7	-0.8	-1.3	-1.1	0.4	-0.8	0.8	-0.7	-0.7	-1.1
Condit. Reinf. lever presses	0.5	0.7	2.6	-0.7	-1.0	-0.7	1.1	0.4	-0.4	0.4	1.6	0.3
Condit. Reinf. lever reinforcers received	1.1	1.5	3.8	-1.0	-2.0	-1.8	1.7	-0.7	0.7	-0.7	0.3	-1.0
Conditioned reinforcement - actives	0.1	0.1	0.5	0.3	-0.3	0.3	0.7	-0.1	-0.0	-0.2	0.1	0.2
Conditioned reinforcement - inactives	0.6	0.8	1.7	0.2	0.6	1.0	-0.6	0.9	-1.0	1.0	1.0	1.3
Conditioned locomotion	0.1	0.1	0.6	0.8	0.5	0.5	0.2	-0.1	-0.0	-0.1	-0.1	0.4
Patch foraging indifference point 0 sec	0.3	0.5	1.0	0.1	0.7	1.0	-0.3	0.5	-0.5	0.8	0.8	1.0
Patch foraging indifference point AUC	0.1	0.2	0.3	0.5	0.6	0.2	0.1	0.4	-0.5	0.2	0.6	0.5
Delay disc. indifference point, 0s delay	0.5	0.6	1.2	-0.6	-0.8	-0.2	0.6	-1.1	1.1	-0.9	-0.4	-0.5
Delay disc. indifference point, 16s delay	0.8	0.9	1.6	0.4	0.1	-1.0	-0.6	-1.1	1.0	-1.2	-1.3	-1.1
Delay disc. indifference point, 2s delay	0.6	0.6	1.4	0.4	0.2	-0.1	-0.3	-1.2	1.2	-1.1	-0.9	-0.8
Delay disc. indifference point, 24s delay	0.4	0.5	1.9	0.6	1.0	0.2	-1.4	0.5	-0.6	0.3	0.3	0.5
Delay disc. indifference point, 4s delay	0.4	0.4	0.9	-0.0	0.1	-0.3	-0.9	-0.7	0.7	-0.8	-0.8	-0.7
Delay disc. indifference point, 8s delay	0.3	0.4	2.6	-0.3	0.4	-0.3	-1.6	-0.4	0.2	-0.5	-0.0	-0.3
Indifference point function ln k	0.1	0.2	1.4	0.1	0.2	0.2	-0.5	-0.3	0.4	-0.2	-1.2	-0.3
Indifference point function log k	0.1	0.2	1.4	0.1	0.2	0.2	-0.5	-0.3	0.4	-0.2	-1.2	-0.3
Patch foraging total patch changes 0 sec	0.2	0.4	0.8	0.0	0.6	0.9	-0.4	0.4	-0.4	0.6	0.7	0.9
Patch foraging total patch changes 12 sec	0.4	0.6	1.5	0.7	-0.4	-0.4	1.2	-0.9	0.8	-1.0	-0.1	-0.5
Patch foraging total patch changes 18 sec	0.6	0.9	1.9	0.9	1.3	1.4	0.2	0.5	-0.5	0.7	1.1	1.3
Patch foraging total patch changes 24 sec	0.2	0.4	1.3	1.1	1.0	0.9	0.4	-0.3	0.2	-0.2	-0.0	0.3
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	0.2	-0.0	0.1	0.4	-0.1	0.1	-0.1	0.1	-0.2
Patch foraging time to switch 0 sec	0.1	0.2	0.7	0.1	-0.1	-0.2	0.8	0.2	-0.1	0.3	0.9	0.2
Patch foraging water rate 0 sec	2.0	4.2	8.4	1.8	-0.1	-0.3	1.7	-2.6	2.6	-2.5	-2.9	-1.8
Patch foraging water rate 12 sec	0.5	1.0	4.4	2.1	1.0	1.1	0.9	-0.5	0.5	-0.4	-1.2	0.1
Patch foraging water rate 18 sec	0.4	0.6	2.0	0.6	-0.1	0.0	0.7	-0.8	0.7	-0.8	-1.4	-0.7
Patch foraging water rate 24 sec	1.9	2.7	5.5	2.3	1.0	0.2	1.7	-1.8	1.8	-1.7	-2.2	-0.8
Patch foraging water rate 6 sec	3.3	4.8	12.9	3.6	1.2	0.8	2.5	-2.2	2.2	-2.0	-2.6	-1.0
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.8	-0.7	-0.6	-0.7	-0.1	0.6	-0.6	0.5	0.9	0.4
Distance traveled before self-admin	0.5	0.7	1.1	0.4	-0.6	-0.9	0.6	-1.0	1.0	-1.1	-0.7	-0.9
Distance traveled after self-admin	0.3	0.3	0.9	-0.5	-0.3	-0.9	-0.3	-0.7	0.7	-0.7	-0.4	-0.4
Extensor digitorum longus weight	0.1	0.6	2.3	1.5	0.8	0.7	-0.6	-0.4	0.4	-0.5	-0.9	-0.3
Bone: elastic displacement	1.5	1.7	7.4	-2.7	-1.4	-0.8	-2.1	0.6	-0.6	0.3	0.4	-0.5
Bone: elastic work	1.4	1.9	8.8	-2.1	-0.5	-0.1	-3.0	0.9	-0.9	0.8	0.8	0.3
Bone: endosteal estimation	0.2	0.4	1.6	1.3	1.1	0.2	0.0	-0.3	0.3	-0.2	-0.5	-0.3
Bone: endosteal perimeter	1.4	3.1	8.4	2.9	1.3	0.2	0.8	-1.8	1.8	-1.7	-2.4	-1.4
Epididymis fat weight	2.0	7.0	12.2	3.5	0.4	-0.1	3.5	-3.1	3.0	-3.0	-2.5	-2.1
Delta time in closed arm before/after self-admin	0.5	0.4	0.8	0.8	-0.2	-0.7	0.9	-0.5	0.5	-0.5	-0.7	-0.8
Delta time in open arm before/after self-admin	1.4	1.4	4.5	-2.1	-0.7	-0.1	-1.4	0.9	-0.9	1.1	1.4	0.7
Diff in mean of infusions in LGA sessions	1.3	1.6	5.3	-1.4	-2.3	-2.0	0.5	-0.6	0.6	-0.7	-0.4	-1.4
Delay discount exponential model param	0.4	0.4	1.3	-0.1	-0.3	0.5	1.1	0.7	-0.6	0.8	0.6	0.6
Extinction: sum of active levers before priming	0.1	0.1	0.6	-0.7	-0.3	-0.3	-0.8	-0.1	0.1	-0.1	-0.1	-0.2
Active lever presses in extinction session 6	1.3	1.3	2.1	-0.4	-1.2	-1.5	1.1	-1.2	1.2	-1.2	-0.4	-1.2
Bone: final force	0.2	0.3	0.7	0.6	0.1	-0.8	-0.3	-0.6	0.6	-0.5	-0.7	-0.4
Bone: final moment	0.2	0.4	1.0	0.5	-0.2	-1.0	-0.2	-0.7	0.7	-0.6	-0.7	-0.5
Food consumed during 24 hour testing period	0.8	1.1	4.5	1.0	1.4	2.1	-0.6	0.4	-0.4	0.6	-0.8	0.8
Glucose	0.1	0.1	0.3	-0.3	-0.5	-0.6	-0.2	0.1	-0.1	0.2	0.1	-0.1
Heart weight	2.0	3.1	4.9	1.9	0.1	-1.4	1.6	-2.2	2.2	-2.1	-1.9	-1.4
Delay discount hyperbolic model param	0.5	0.6	1.1	-0.2	-0.3	0.6	1.0	0.9	-0.8	1.0	0.8	0.8
Intermittent access intake day 1-15 change	1.5	3.0	7.1	1.6	-1.0	-0.5	2.7	-1.9	1.8	-2.0	-1.7	-1.6
Intermittent access intake escalation	1.6	3.3	7.5	1.5	-1.2	-0.7	2.7	-2.0	2.0	-2.0	-1.7	-1.7
Intermittent access intake escalation 2	1.3	1.5	3.4	1.3	-0.2	-0.2	1.9	-1.3	1.3	-1.4	-1.3	-1.0
Intermitt. access day 1 inactive lever presses	0.7	2.5	5.3	-2.3	-0.4	-0.3	-1.8	1.7	-1.8	1.8	1.6	1.3
Intermitt. access day 15 inactive lever presses	0.3	0.6	1.7	-0.9	0.4	0.6	-1.3	0.6	-0.7	0.7	0.4	0.8
Intermitt. access escalation Index	0.3	0.4	1.1	-1.1	-1.0	-0.7	0.1	0.6	-0.5	0.5	0.5	-0.2
Intermittent access day 1 total infusions	1.9	3.0	8.1	2.0	2.9	2.7	-1.4	1.0	-1.1	1.0	0.3	1.6
Intermittent access day 15 total infusions	1.2	1.7	6.9	2.6	1.7	2.1	0.6	-0.4	0.3	-0.3	-0.7	0.5
Intermittent access terminal intake (last 3 days)	1.2	1.6	6.0	2.5	1.6	1.9	0.4	-0.5	0.5	-0.4	-0.9	0.4
Intermittent access total infusions	1.2	1.4	4.3	2.1	1.9	2.1	-0.3	-0.2	0.1	-0.1	-0.6	0.7
Intermittent access day 1 locomotion	4.0	5.1	10.1	1.4	3.2	3.0	-2.3	1.9	-1.9	2.1	1.4	2.6
Intermittent access day 15 total locomotion	2.4	4.4	8.8	1.1	2.6	3.0	-1.4	1.9	-2.0	2.0	1.4	2.6
Intermittent access total locomotion	3.7	4.5	9.5	1.7	3.0	3.1	-1.5	1.7	-1.8	1.8	1.1	2.5
Intermittent access standard deviation	1.1	2.3	5.6	2.4	0.5	0.3	1.8	-1.6	1.5	-1.7	-1.6	-0.9
Left kidney weight	1.4	6.4	24.7	5.0	2.8	1.9	1.5	-2.1	2.1	-2.0	-2.3	-0.3
Right kidney weight	1.5	6.7	23.7	4.9	2.2	1.1	2.4	-2.5	2.5	-2.4	-2.5	-0.9
Cocaine induced anxiety	0.5	0.8	3.9	-2.0	-1.0	-1.0	-0.8	0.5	-0.5	0.1	0.1	-0.4
Post-drug Anxiety	0.6	0.7	3.5	-1.9	-1.0	-0.7	-0.6	0.2	-0.2	0.0	-0.1	-0.5
Baseline Anxiety	0.2	0.2	0.7	0.8	0.5	0.8	0.5	-0.3	0.3	-0.0	-0.2	0.3
Tail length	5.3	20.9	55.1	7.4	7.4	6.8	0.3	1.7	-1.7	1.8	1.0	4.7
Length with tail	5.2	22.8	86.7	9.3	7.7	6.4	2.1	-0.4	0.3	-0.2	-0.5	3.6
Length without tail	2.4	7.8	33.0	5.7	3.9	2.6	1.9	-1.7	1.6	-1.5	-1.4	1.0
Times rat made contact with spout	2.5	2.8	6.0	2.0	-0.6	-0.2	2.4	-1.7	1.7	-1.7	-2.1	-1.3
Lifetime Intake	1.1	1.3	4.4	2.1	1.7	1.8	0.1	-0.6	0.4	-0.4	-0.8	0.4
Liver weight, left	2.0	3.3	14.0	3.7	2.1	1.7	1.7	-0.9	0.9	-1.0	-1.7	0.1
Liver weight, right	1.3	2.2	8.7	3.0	1.8	2.0	1.0	-0.6	0.6	-0.4	-1.2	0.6
Locomotor activity	3.6	5.6	10.0	2.9	-0.3	-0.7	3.2	-2.7	2.7	-2.7	-2.4	-1.8
Locomotor testing distance	3.2	5.8	10.3	2.3	-0.8	-1.1	3.2	-2.8	2.8	-2.8	-2.6	-2.2
Locomotor testing rearing	1.1	2.1	3.6	1.4	-0.6	-0.4	1.9	-1.6	1.7	-1.6	-1.8	-1.3
Locomotion in novel chamber	0.2	0.2	0.7	-0.1	-0.5	-0.8	0.0	0.4	-0.4	0.5	0.6	0.2
Locomotion in novel chamber post-restriction	0.8	1.3	2.5	1.0	1.6	1.6	-0.9	1.2	-1.1	1.0	0.3	1.1
Fecal boli incidents, locomotor time 1	0.7	1.0	1.7	0.6	1.2	1.0	-0.4	1.0	-1.0	1.0	1.1	1.3
Change in fecal boli incidents, locomotor task	1.1	1.1	3.0	-1.5	-1.1	-1.7	-0.1	-0.7	0.7	-0.6	-1.0	-1.2
Time >=10cm from walls, locomotor time 1	0.8	0.9	1.2	-0.9	-1.1	-1.0	0.3	-0.9	0.9	-1.1	-0.8	-1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.3	0.0	-0.3	-0.3	0.1	-0.3	0.3	-0.5	-0.5	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.4	-0.4	-0.6	-0.5	-0.1	-0.2	0.2	-0.4	-0.4	-0.2
Rest time, locomotor task time 1	0.5	0.6	3.0	-1.7	-1.0	-0.2	-0.6	0.5	-0.5	0.6	0.6	0.3
Distance moved, locomotor task time 1	1.4	2.1	4.2	1.1	-0.4	-0.9	2.1	-1.6	1.6	-1.7	-1.4	-1.5
Vertical activity count, locomotor time 1	1.5	3.6	7.0	2.0	-0.6	-1.3	2.6	-2.1	2.1	-2.1	-1.7	-1.8
Time >=10cm from walls, locomotor time 2	1.0	1.5	4.9	-1.7	-2.2	-1.5	0.6	-0.8	0.8	-0.7	-0.1	-1.0
Bouts of movement, locomotor time 2	0.3	0.5	1.7	0.5	0.5	0.1	-0.3	-0.9	0.9	-0.9	-1.3	-0.3
Total resting periods, locomotor time 2	0.4	0.6	2.0	0.1	0.1	-0.2	-0.3	-1.0	1.0	-1.0	-1.4	-0.6
Rest time, locomotor task time 2	0.3	0.4	1.0	-1.0	-0.9	-0.7	-0.3	-0.2	0.2	-0.3	-0.5	-0.7
Distance moved, locomotor task time 2	0.5	0.6	2.8	0.5	-0.4	0.1	1.7	-0.7	0.7	-0.7	-0.3	-0.5
Vertical activity count, locomotor time 2	1.7	2.4	8.4	2.0	-0.4	-0.4	2.9	-1.6	1.6	-1.6	-0.8	-1.0
Light reinforcement 1	0.1	0.3	1.6	0.7	0.0	0.1	1.3	-0.3	0.3	-0.4	-0.7	-0.4
Light reinforcement 2	0.5	0.8	1.6	0.1	1.3	1.0	-0.8	1.0	-1.0	0.9	0.6	0.8
Bone: marrow area	0.2	0.4	1.5	1.2	1.1	0.2	0.1	-0.3	0.3	-0.2	-0.5	-0.3
Bone: maximum diameter	1.6	3.0	6.5	2.5	0.7	-0.0	1.2	-1.9	1.9	-1.8	-2.6	-1.4
Bone: maximum force	0.1	0.2	0.4	0.4	0.4	-0.6	-0.7	-0.3	0.3	-0.2	-0.2	-0.2
Bone: maximum moment	0.1	0.2	0.7	0.1	-0.1	-0.8	-0.5	-0.5	0.5	-0.4	-0.2	-0.3
Mean time between licks in bursts	1.1	2.7	4.4	0.4	-1.6	-1.5	0.5	-2.0	2.0	-2.1	-1.5	-2.1
Mean num. licks in bursts	0.0	0.0	0.2	-0.1	-0.4	-0.1	0.3	-0.1	0.0	0.0	-0.1	0.1
Cd content in liver	0.1	0.1	0.6	-0.1	-0.4	-0.7	-0.4	-0.2	0.2	-0.1	0.3	-0.2
Co content in liver	0.1	0.1	0.4	0.4	0.1	0.3	0.6	-0.2	0.2	-0.2	-0.3	-0.0
Cu content in liver	1.0	1.2	2.4	0.5	1.5	1.6	-0.9	1.1	-1.1	1.0	0.7	1.2
Fe content in liver	0.3	0.4	1.7	0.7	1.3	0.4	-1.0	0.2	-0.2	0.2	0.1	0.6
K content in liver	4.4	4.2	7.5	-0.2	1.2	1.9	-0.2	2.5	-2.5	2.5	2.6	2.7
Mg content in liver	0.6	0.6	1.6	-0.6	0.1	0.4	0.0	1.0	-1.0	0.9	1.3	1.0
Mn content in liver	0.2	0.2	1.3	0.2	-0.1	-0.4	1.1	-0.2	0.2	-0.2	-0.1	-0.3
Na content in liver	0.6	0.6	0.9	-0.3	0.5	0.9	0.0	1.0	-1.0	0.9	0.9	0.9
Rb content in liver	3.6	4.1	5.8	-0.4	1.8	2.0	-2.4	2.3	-2.3	2.2	1.9	2.3
Se content in liver	0.2	0.2	0.9	-0.1	0.3	0.0	0.3	0.5	-0.5	0.5	1.0	0.6
Sr content in liver	0.4	0.3	1.1	-0.5	-1.1	-0.9	0.5	-0.3	0.3	-0.3	0.5	-0.1
Zn content in liver	1.1	1.2	3.0	1.7	1.7	1.7	-0.1	0.5	-0.5	0.4	0.4	1.1
Bone: minimum diameter	2.7	4.9	10.0	3.2	0.7	-0.4	1.7	-2.6	2.6	-2.5	-2.7	-1.7
Time in familiar zone, hab. session 1	0.1	0.1	0.4	-0.6	-0.4	-0.4	0.2	0.1	-0.1	0.2	-0.1	-0.2
Time in novel zone, hab. session 1	0.2	0.2	1.3	0.1	0.3	0.2	-1.1	-0.2	0.2	-0.3	-0.5	-0.3
Total zone transitions, hab. session 1	3.3	4.6	11.3	0.9	-1.7	-2.6	3.4	-2.3	2.3	-2.2	-1.0	-1.8
Total locomotion distance, hab. session 1	3.5	5.0	13.6	0.7	-1.9	-2.7	3.7	-2.3	2.3	-2.2	-0.9	-1.9
Locomotion velocity, hab. session 1	4.9	6.9	20.1	0.9	-2.3	-3.1	4.5	-2.7	2.7	-2.6	-1.1	-2.1
Time in familiar zone, hab. session 2	0.3	0.3	0.7	-0.1	-0.9	0.1	0.6	-0.5	0.5	-0.5	-0.7	-0.6
Time in novel zone, hab. session 2	0.3	0.3	1.2	-0.5	0.3	-0.7	-1.1	0.3	-0.3	0.3	0.3	0.1
Total zone transitions, hab. session 2	3.4	4.3	8.8	-0.1	-2.2	-3.0	2.8	-2.1	2.1	-2.1	-0.7	-1.9
Total locomotion distance, hab. session 2	5.6	7.3	14.6	0.2	-2.8	-3.4	3.8	-2.8	2.8	-2.7	-1.5	-2.7
Locomotion velocity, hab. session 2	5.6	7.4	15.2	0.2	-2.8	-3.4	3.9	-2.8	2.8	-2.7	-1.5	-2.7
Novel to familiar place preference ratio	0.8	0.9	2.0	-0.5	0.5	1.4	-0.6	1.1	-1.1	1.2	0.7	1.1
Novelty place preference	0.8	0.9	1.6	-0.9	0.2	1.3	-0.7	1.1	-1.1	1.1	0.6	1.0
Time in novel zone, NPP test	0.6	0.6	1.4	-0.7	0.2	1.2	-0.7	0.8	-0.8	0.9	0.3	0.8
Total zone transitions, NPP test	1.1	1.6	3.8	0.8	-0.6	-2.0	1.6	-1.4	1.4	-1.5	-0.4	-1.0
Total locomotion distance, NPP test	2.5	3.4	10.4	0.9	-1.4	-2.3	3.2	-1.8	1.8	-1.7	-0.5	-1.5
Locomotion velocity, NPP test	1.7	2.4	8.8	0.6	-1.3	-2.2	3.0	-1.3	1.3	-1.2	-0.1	-1.1
Intraocular pressure	0.1	0.1	0.3	-0.6	-0.3	-0.2	-0.3	0.0	-0.0	-0.1	0.1	-0.4
Delta distance traveled before/after self-admin	0.1	0.1	0.2	-0.4	0.1	-0.1	-0.2	0.2	-0.2	0.2	0.4	0.4
Delta ambulatory time before/after self-admin	0.2	0.3	1.2	-1.1	0.1	-0.2	-0.7	0.3	-0.3	0.3	0.6	0.4
Parametrial fat weight	0.7	1.6	2.9	-0.0	-0.8	-1.2	0.1	-1.6	1.6	-1.5	-1.7	-1.5
Pavlov. Cond. lever latency	0.8	1.0	3.1	1.4	1.7	1.3	-1.2	0.3	-0.3	0.2	-0.5	0.4
Pavlov. Cond. magazine entry latency	1.8	2.3	4.6	-1.0	-1.9	-2.2	1.9	-1.2	1.2	-1.3	-0.6	-1.6
Pavlov. Cond. change in total contacts	1.8	1.9	4.9	-0.5	-1.6	-1.5	2.2	-1.3	1.3	-1.3	-0.4	-1.5
Pavlov. Cond. index score	2.3	2.9	6.1	-1.3	-2.5	-2.3	2.2	-1.3	1.3	-1.4	-0.4	-1.6
Pavlov. Cond. latency score	1.8	2.3	5.5	-1.4	-2.4	-2.2	2.0	-0.9	0.9	-1.0	0.1	-1.3
Pavlov. Cond. lever contacts	0.9	1.1	3.1	-1.2	-1.8	-1.3	1.5	-0.5	0.5	-0.4	0.5	-0.5
Pavlov. Cond. magazine entry number	1.8	2.3	4.1	0.7	1.7	2.0	-1.9	1.4	-1.4	1.5	0.7	1.7
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.8	0.6	0.3	-0.5	-0.5	-1.0	1.0	-0.7	-1.3	-0.9
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.0	6.1	-1.2	-2.5	-2.4	2.2	-1.4	1.4	-1.5	-0.4	-1.7
Pavlov. Cond. response bias	2.0	2.5	5.2	-1.3	-2.3	-2.2	2.0	-1.2	1.2	-1.2	-0.4	-1.5
Pavlov. Cond. lever latency	1.0	1.3	3.2	0.5	1.6	1.8	-1.6	0.8	-0.8	0.8	-1.0	0.8
Pavlov. Cond. magazine entry latency	0.5	0.5	1.0	0.3	-0.5	-1.0	1.0	-0.7	0.7	-0.7	-0.3	-0.9
Pavlov. Cond. change in total contacts	1.0	1.6	4.7	1.4	-0.2	-1.2	2.2	-1.3	1.3	-1.2	0.3	-0.8
Pavlov. Cond. index score	0.7	0.9	2.9	0.6	-0.5	-1.2	1.7	-0.9	0.9	-0.9	0.3	-0.8
Pavlov. Cond. latency score	0.6	0.7	2.9	0.4	-0.6	-1.1	1.7	-0.7	0.7	-0.6	0.4	-0.6
Pavlov. Cond. lever contacts	1.3	1.8	3.9	-0.2	-1.6	-2.0	1.8	-1.3	1.3	-1.3	0.5	-1.3
Pavlov. Cond. magazine entry number	1.7	2.1	4.9	-1.1	0.6	1.5	-2.2	1.5	-1.5	1.5	0.9	1.6
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.5	-0.6	-0.4	0.3	-0.6	0.0	-0.0	-0.0	-0.7	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	3.2	0.7	-0.5	-1.2	1.8	-0.9	0.9	-0.9	0.3	-0.8
Pavlov. Cond. response bias	1.6	2.2	4.0	0.3	-1.4	-1.9	2.0	-1.6	1.6	-1.6	-0.0	-1.6
Time in closed arm before self-admin	0.1	0.1	0.4	0.6	0.1	0.3	0.2	-0.3	0.3	-0.2	-0.3	0.0
Time in closed arm after self-admin	0.2	0.2	0.6	0.8	0.0	-0.3	0.8	-0.3	0.2	-0.1	-0.5	-0.5
Time in open arm before self-admin	0.2	0.3	1.0	-0.1	-0.5	-1.0	0.9	0.1	-0.1	-0.2	-0.0	-0.5
Time in open arm after self-admin	1.2	1.4	4.2	-2.0	-0.8	-0.6	-1.0	1.1	-1.1	1.0	1.4	0.6
Bone: periosteal estimation	0.4	0.9	3.4	1.8	1.1	0.1	0.2	-0.9	0.9	-0.7	-1.1	-0.5
Bone: periosteal perimeter	0.8	1.4	3.3	1.8	0.7	-0.3	0.3	-1.3	1.3	-1.2	-1.7	-0.9
Bone: post-yield work	0.1	0.1	0.4	0.5	0.7	0.4	-0.4	0.2	-0.2	0.2	-0.1	0.2
Progressive ratio test 1 active lever presses	2.2	2.8	10.3	3.2	2.5	2.6	0.5	-0.1	-0.0	0.1	-0.1	1.2
Progressive ratio test 1 breakpoint	2.2	2.7	10.4	3.2	2.5	2.5	0.5	-0.1	0.0	0.1	-0.1	1.2
Progressive ratio test 1 inactive lever presses	0.7	0.9	2.3	0.3	0.8	1.5	-0.7	0.9	-1.0	0.9	0.7	1.3
Progressive ratio test 2 active lever presses	0.7	0.8	3.1	1.8	0.5	1.2	1.2	-0.6	0.5	-0.5	-0.7	0.1
Progressive ratio test 2 breakpoint	0.8	0.9	3.2	1.8	0.4	1.1	1.3	-0.7	0.6	-0.6	-0.7	0.1
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.8	0.0	0.4	0.9	-0.4	0.2	-0.3	0.4	0.2	0.7
Incentive Sensitization - Responses	0.4	0.5	1.8	1.2	-0.2	0.4	1.3	-0.6	0.6	-0.5	-0.6	-0.3
Incentive Sensitization - Breakpoint	0.3	0.4	1.4	1.0	-0.3	0.4	1.2	-0.5	0.4	-0.4	-0.5	-0.2
Sum of active levers in priming session hrs 5-6	2.2	2.1	4.8	0.3	-1.5	-0.8	2.2	-1.6	1.6	-1.6	-1.0	-1.4
Progressive ratio	0.2	0.3	1.8	-1.4	-0.4	-0.4	-0.7	0.3	-0.3	0.3	0.4	0.0
Food seeking constrained by brief footshock	0.8	0.9	3.2	1.8	1.4	1.5	0.7	-0.3	0.3	-0.2	-0.5	0.5
Seeking ratio, punishment vs. effort	0.4	0.6	2.3	1.5	0.6	0.7	0.7	-0.6	0.6	-0.5	-0.9	-0.1
Retroperitoneal fat weight	1.1	4.5	10.8	3.3	0.6	0.2	3.0	-2.2	2.2	-2.1	-2.0	-1.2
Reaction time number correct	0.2	0.3	0.8	-0.0	-0.9	-0.6	0.6	-0.4	0.4	-0.5	-0.7	-0.6
Reaction time mean minus median	0.4	1.0	2.0	-1.4	-1.0	-0.4	-1.3	0.8	-0.8	0.9	1.2	0.6
Reaction time mean minus median AUC	0.3	0.7	1.8	-1.3	-1.3	-0.4	-1.0	0.5	-0.5	0.5	0.9	0.3
Reaction time num false alarms	0.8	1.1	1.7	-1.3	-0.3	0.7	-1.2	1.2	-1.3	1.2	0.8	0.9
Reaction time num false alarms AUC	0.7	1.1	2.4	-1.6	-0.5	0.4	-1.4	1.1	-1.2	1.1	0.7	0.7
Reaction time trials correct on left	0.2	0.3	0.8	-0.0	-0.9	-0.6	0.6	-0.4	0.4	-0.5	-0.7	-0.6
Reaction time trials on left	0.2	0.3	1.0	-0.1	-1.0	-0.7	0.6	-0.4	0.4	-0.4	-0.6	-0.6
Reaction time mean	0.5	0.7	1.2	0.2	-0.7	-0.9	0.1	-1.0	1.1	-1.1	-0.8	-1.0
Reaction time mean AUC	0.2	0.4	0.7	0.5	-0.4	-0.5	-0.1	-0.8	0.8	-0.9	-0.7	-0.6
Median of all reaction times	1.0	1.4	2.6	0.9	-0.3	-0.8	0.6	-1.5	1.5	-1.6	-1.4	-1.3
Reaction time omissions	1.2	1.7	5.4	-2.3	-2.0	-1.4	-1.8	0.4	-0.4	0.4	0.5	-0.7
Reaction time false alarm rate	0.9	1.2	2.1	-1.3	0.1	0.6	-1.4	1.2	-1.3	1.2	1.1	1.0
Reaction time premature initiation rate	1.4	1.9	5.5	0.1	-1.5	-2.1	2.3	-1.1	1.0	-1.0	0.3	-1.3
Reaction time premature initiations	1.0	1.8	5.5	0.3	-1.7	-1.9	2.3	-0.9	0.8	-0.9	0.1	-1.2
Std. dev. reaction times	0.5	0.9	1.9	-1.4	-1.3	-0.9	-1.4	0.4	-0.4	0.5	0.9	0.1
Reaction time trials completed	0.2	0.3	1.0	-0.1	-1.0	-0.7	0.6	-0.4	0.4	-0.4	-0.6	-0.6
Reaction time trials AUC	0.2	0.4	0.9	0.1	-0.9	-0.7	0.8	-0.5	0.5	-0.5	-0.6	-0.6
Run reversals in cocaine runway, females	0.2	0.2	0.6	0.8	0.5	0.7	0.0	0.0	0.0	-0.2	-0.1	0.3
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.2	-0.3	-0.4	0.4	-0.5	0.5	-0.6	-0.2	-0.5
Latency to leave start box in cocaine runway	0.7	0.8	1.4	0.4	-1.0	-0.9	1.2	-0.8	0.8	-0.9	-0.8	-1.1
Latency to leave start box in cocaine runway, F	1.7	2.0	3.1	-0.7	-1.5	-1.7	1.3	-1.3	1.3	-1.5	-1.3	-1.8
Latency to leave start box in cocaine runway, M	0.8	0.8	1.7	1.3	0.5	1.0	-0.0	0.9	-0.9	0.9	0.8	0.9
Std. dev. time between licks in bursts	1.7	2.3	4.6	-0.8	-2.0	-2.1	0.5	-1.6	1.6	-1.6	-0.4	-1.8
Total sessions with >9 infusions	1.0	1.2	4.8	2.2	1.4	1.5	0.8	-0.6	0.5	-0.5	-0.6	0.3
Short access day 1 total inactive lever presses	0.2	0.2	0.6	0.4	0.8	0.7	-0.4	0.3	-0.4	0.3	-0.1	0.3
Short access day 10 total inactive lever presses	1.1	2.8	12.0	-3.5	-1.7	-1.1	-1.9	1.1	-1.2	1.1	1.0	0.4
Short access day 1 total infusions	0.2	0.2	0.4	0.5	0.6	0.5	0.1	-0.5	0.4	-0.5	-0.6	-0.3
Short access day 10 total infusions	1.4	1.8	5.5	2.1	2.3	2.1	-0.7	-0.2	0.1	-0.1	-0.4	0.9
Short access total infusions	0.6	0.8	2.0	1.4	1.3	1.4	-0.1	-0.5	0.5	-0.5	-0.7	0.2
Short access day 1 locomotion	0.3	0.4	1.2	0.6	0.5	1.1	-0.0	0.5	-0.5	0.6	0.6	0.9
Short access day 10 total locomotion	0.3	0.6	1.5	-0.4	0.9	0.3	-1.2	0.6	-0.7	0.6	0.6	0.9
Short access total locomotion	1.0	1.2	3.0	0.9	1.5	1.7	-0.6	0.7	-0.8	0.9	0.8	1.5
One hour access (0.3 mA shock)	2.7	3.2	12.6	3.6	1.6	1.7	1.9	-1.4	1.3	-1.3	-1.2	0.1
Compulsive drug intake	0.8	1.0	1.8	-0.6	0.2	0.4	-1.0	1.3	-1.2	1.2	1.3	1.0
One hour access (shock baseline)	1.8	2.8	9.3	3.0	1.4	1.6	1.8	-1.5	1.4	-1.4	-1.5	-0.1
Social response proportion	0.7	0.8	2.5	1.6	-0.0	-0.6	0.9	-1.0	1.0	-1.0	-0.6	-0.7
Social responses	2.4	3.1	4.8	0.8	-2.0	-1.7	2.2	-1.9	1.8	-2.0	-1.5	-1.8
Social time	0.4	0.5	1.1	1.0	-0.5	-0.3	1.1	-0.7	0.7	-0.8	-0.5	-0.6
Soleus weight	0.2	0.5	1.0	0.9	0.1	-0.3	-0.0	-0.9	0.9	-1.0	-0.5	-0.8
Bone: stiffness	0.4	0.7	3.3	1.8	0.9	-0.5	0.8	-0.7	0.7	-0.5	-0.4	0.0
Tibialis anterior weight	0.3	1.0	1.8	0.2	-0.4	-1.0	-0.4	-1.1	1.1	-1.2	-1.3	-1.4
Time to tail flick, vehicle, before self-admin	1.4	1.4	3.6	1.9	-0.3	-0.5	1.5	-1.2	1.2	-1.2	-1.1	-1.0
Time to tail flick, vehicle, after self-admin	1.3	1.8	3.4	-1.7	-1.8	-1.6	1.2	-1.0	1.0	-1.1	-0.7	-1.3
Time to tail flick, test, before self-admin	0.7	0.7	1.6	0.8	1.3	0.6	-0.6	0.9	-0.9	0.9	0.6	0.9
Time to tail flick, test, after self-admin	0.3	0.3	0.8	0.5	-0.0	-0.8	0.9	-0.5	0.5	-0.5	-0.3	-0.6
Delta time to tail flick, vehicle, before/after SA	1.1	1.0	5.1	-2.3	-1.4	-1.0	0.2	-0.4	0.4	-0.5	-0.1	-0.7
Delta time to tail flick, test, before/after SA	0.4	0.4	0.9	-0.8	-0.9	-0.7	0.5	-0.5	0.5	-0.5	-0.0	-0.5
Tibia length	3.1	8.5	34.1	5.8	3.1	1.6	2.1	-2.5	2.5	-2.4	-2.8	-0.4
Ambulatory time before self-admin	0.0	0.0	0.3	0.5	0.3	0.2	-0.1	-0.0	0.0	-0.1	-0.0	0.1
Ambulatory time after self-admin	0.1	0.1	0.4	-0.2	0.1	-0.6	-0.5	-0.4	0.4	-0.5	-0.2	-0.1
Bone: tissue strength	0.4	0.4	1.1	0.4	-0.3	-1.1	0.9	-0.6	0.6	-0.5	0.5	-0.2
Total heroin consumption	2.2	2.6	5.3	-1.1	-1.9	-2.3	1.1	-1.4	1.4	-1.4	-1.1	-2.1
Bone: trabecular number	0.4	0.6	1.1	-0.7	0.2	0.6	-0.6	0.9	-0.9	1.0	0.6	0.9
Bone: trabecular spacing	0.1	0.1	0.5	-0.4	-0.7	-0.2	-0.3	0.0	-0.0	-0.1	0.2	-0.3
Bone: trabecular thickness	0.2	0.2	0.9	0.2	0.6	0.9	-0.1	0.2	-0.2	0.3	-0.2	0.5
Bone: trabecular tissue density	0.4	0.6	1.8	-0.1	0.4	-0.1	1.1	0.8	-0.7	0.8	1.3	0.9
Water consumed over 24 hours	1.5	2.1	6.8	2.3	2.0	2.6	-0.2	0.3	-0.3	0.3	-1.3	0.9
Number of responses in last shaping day	0.3	0.3	0.7	-0.0	-0.6	-0.5	0.9	-0.7	0.6	-0.7	-0.6	-0.6