LOC134479811

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC134479811	0.02	0.02	3.6e-03	0.02	0.02	0.01	0.02	1.7e-03	2.4e-03	8.9e-03	2.1e-03
2	NAcc	intron excision ratio	chr7_10242379_10243044	0.03	0.02	8.2e-04	0.02	0.02	0.01	0.02	3.6e-04	1.1e-03	1.7e-03	1.1e-03
3	Adipose	gene expression	LOC134479811	0.1	0.07	2.4e-07	0.02	0.05	0.05	0.05	1.9e-03	2.3e-06	4.8e-06	7.5e-06
4	IL	gene expression	LOC134479811	0.16	0.11	2.9e-03	0.05	0.05	0.05	0.05	2.1e-02	2.0e-02	2.2e-02	2.8e-02
5	IC	gene expression	LOC134479811	0.07	0.06	7.2e-03	0.04	0.02	0.03	0.03	1.1e-02	3.4e-02	2.8e-02	2.3e-02
6	NAcc	gene expression	LOC134479811	0.15	0.09	0.0e+00	0.12	0.13	0.14	0.14	2.9e-17	1.3e-19	2.5e-20	4.1e-20
7	PL	gene expression	LOC134479811	0.04	0.03	1.6e-04	0.04	0.04	0.04	0.04	3.3e-05	4.8e-05	3.2e-05	4.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.9	1.7	3.7	0.8	0.8	-1.9	-0.0	1.0	1.9	1.5
Area under the delay curve	1.3	2.1	2.9	-1.7	-1.6	1.0	-1.6	1.6	1.3	1.1
BMI with tail	5.3	18.3	24.2	-4.7	-4.8	3.3	-4.9	4.6	3.4	3.9
BMI without tail	1.0	5.4	7.6	-2.8	-2.7	2.3	-2.7	2.2	1.4	1.7
Body weight	0.8	3.4	4.5	-2.0	-2.0	1.4	-2.1	2.0	1.5	1.8
Weight adjusted by age	0.3	0.8	1.7	-1.1	-1.2	1.3	-0.9	0.6	0.1	0.1
Bone surface	1.7	3.3	9.9	1.8	1.9	-3.1	0.8	0.6	1.8	1.5
Bone volume	1.6	3.1	9.1	1.6	1.7	-3.0	0.6	0.7	2.0	1.5
Breakpoint value in progressive ratio session	2.2	3.9	5.2	1.9	1.9	-0.9	2.1	-2.2	-2.3	-2.2
Number of licking bursts	0.2	0.5	1.9	-0.5	-0.8	1.4	-0.4	-0.0	-0.6	-0.6
Context. condit. distance diff. score	0.1	0.2	0.3	-0.3	-0.3	0.5	-0.6	0.4	0.2	0.5
Locomotion velocity, session 1	0.8	0.9	2.8	1.0	1.2	-1.7	0.9	-0.4	0.3	0.3
Locomotion distance, session 1	1.9	2.4	7.0	1.6	1.8	-2.7	0.8	0.1	1.3	1.1
Locomotion velocity, session 2	5.2	6.2	11.4	3.2	3.3	-3.4	2.6	-1.9	-0.4	-0.6
Locomotion distance, session 2	2.8	3.9	10.9	2.3	2.5	-3.3	1.9	-0.9	0.5	0.1
Locomotion velocity, session 3	5.4	6.2	8.1	2.5	2.5	-1.3	2.8	-2.8	-2.5	-2.5
Locomotion distance, session 3	0.1	0.1	0.2	-0.1	-0.2	0.4	-0.0	-0.0	-0.4	-0.2
Stereotopy head waving bouts, day 3	5.0	6.0	9.4	3.1	2.8	-2.3	2.8	-2.5	-1.5	-1.9
Stereotopy head waving duration, day 3	5.7	7.0	9.6	3.1	2.9	-2.1	3.0	-2.9	-2.0	-2.3
Locomotion velocity, session 7	0.5	0.5	1.1	1.0	0.7	-0.0	0.6	-0.7	-0.7	-0.7
Locomotion distance, session 7	0.4	0.5	2.0	-0.6	-0.9	1.4	-0.7	0.3	-0.3	-0.2
Stereotopy head waving bouts, day 7	0.4	0.5	1.3	0.8	0.5	-1.2	0.2	0.3	0.8	0.7
Stereotopy head waving duration, day 7	0.8	0.9	2.9	1.2	1.1	-1.7	0.8	-0.2	0.5	0.3
Locomotion velocity, session 8	1.4	1.6	4.8	1.4	1.7	-2.2	1.1	-0.5	0.5	0.2
Locomotion distance, session 8	0.5	0.8	1.7	1.2	1.2	-1.3	0.7	-0.4	0.2	0.2
Degree of sensitization distance	0.3	0.3	0.5	-0.4	-0.5	0.4	-0.7	0.6	0.7	0.7
Degree of sensitization stereotypy	1.5	1.6	3.1	-0.7	-1.0	0.0	-1.2	1.6	1.6	1.7
Conditioned locomotion	1.7	2.0	4.2	-2.0	-1.8	2.0	-1.4	0.9	0.0	0.1
Cocaine response after cond. corrected	4.5	6.8	11.3	-3.4	-3.3	3.3	-2.9	2.0	0.8	1.1
Cocaine response after cond. not corrected	4.8	6.9	11.7	-3.3	-3.3	3.4	-2.9	2.0	0.8	1.1
Cocaine response before conditioning	0.5	0.7	1.7	1.3	1.0	-0.7	0.9	-0.5	-0.5	-0.4
Saline control response	0.2	0.3	0.7	-0.8	-0.8	0.8	-0.5	0.3	-0.3	-0.1
Bone: connectivity density	0.8	1.2	3.0	0.4	0.4	-1.3	-0.4	1.1	1.7	1.5
Bone: cortical apparent density	0.7	1.1	1.5	-1.2	-1.2	0.7	-1.2	1.2	0.9	0.9
Bone: cortical area	0.5	0.8	1.9	0.1	-0.3	-0.4	-0.7	1.2	1.4	1.3
Bone: cortical porosity	0.3	0.3	0.9	0.6	0.6	-1.0	0.4	-0.1	0.4	0.2
Bone: cortical porosity	0.5	0.6	1.7	0.7	0.6	-1.3	0.2	0.3	1.0	0.8
Bone: cortical thickness	0.9	1.6	2.9	-0.5	-0.9	0.0	-1.3	1.7	1.7	1.6
Bone: cortical thickness	0.4	0.5	1.4	-0.4	-0.6	1.2	-0.1	-0.3	-0.8	-0.7
Bone: cortical tissue density	0.5	0.8	1.1	-1.0	-1.0	0.5	-1.0	1.0	0.7	0.7
Condit. Reinf. active minus inactive responses	4.1	4.7	6.2	2.2	2.3	-1.4	2.4	-2.5	-2.0	-2.0
Condit. Reinf. active-inactive response ratio	2.0	2.2	3.8	1.1	1.1	-0.1	1.5	-1.9	-1.9	-1.8
Condit. Reinf. active responses	3.8	4.8	7.6	2.5	2.8	-2.4	2.5	-2.1	-1.1	-1.4
Condit. Reinf. inactive responses	1.5	1.9	5.4	1.6	1.8	-2.3	1.3	-0.6	0.4	0.2
Incentive salience index mean	2.6	3.3	5.1	2.3	2.3	-2.0	2.0	-1.8	-0.9	-1.0
Condit. Reinf. lever presses	1.0	1.5	4.7	1.2	1.2	-2.2	0.5	0.2	1.3	1.1
Condit. Reinf. active minus inactive responses	1.4	2.1	4.3	1.1	0.7	0.2	1.4	-1.6	-2.0	-2.1
Condit. Reinf. active-inactive response ratio	0.4	0.6	1.4	-0.6	-0.8	1.2	-0.1	-0.2	-0.9	-0.9
Condit. Reinf. active responses	1.5	2.1	3.7	1.4	1.0	-0.2	1.5	-1.5	-1.9	-1.9
Condit. Reinf. inactive responses	0.8	1.1	1.6	1.2	1.0	-0.4	1.1	-1.0	-1.2	-1.2
Condit. Reinf. lever presses	1.4	2.1	3.9	1.2	1.0	-0.1	1.4	-1.6	-2.0	-1.9
Condit. Reinf. lever reinforcers received	1.2	1.7	3.6	1.0	0.5	0.3	1.2	-1.3	-1.9	-1.9
Conditioned reinforcement - actives	0.3	1.1	1.8	1.0	0.7	0.3	1.0	-1.4	-1.3	-1.2
Conditioned reinforcement - inactives	0.0	0.1	0.4	0.1	-0.3	0.6	-0.2	-0.0	-0.1	-0.1
Conditioned locomotion	5.0	7.5	9.8	3.1	3.0	-2.0	3.1	-2.9	-2.3	-2.5
Patch foraging indifference point 0 sec	0.1	0.3	0.6	-0.3	-0.4	-0.1	-0.5	0.7	0.8	0.7
Patch foraging indifference point AUC	0.3	0.7	1.0	0.7	0.7	-0.3	1.0	-1.0	-1.0	-1.0
Delay disc. indifference point, 0s delay	6.6	7.5	13.8	-1.9	-1.9	-0.1	-2.7	3.3	3.7	3.6
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	-0.6	-0.5	0.2	-0.4	0.3	0.2	0.2
Delay disc. indifference point, 2s delay	4.7	5.3	8.0	-2.1	-2.1	0.9	-2.6	2.8	2.5	2.5
Delay disc. indifference point, 24s delay	0.6	0.9	1.7	-1.3	-1.2	1.0	-1.0	0.8	0.5	0.4
Delay disc. indifference point, 4s delay	0.9	0.9	1.3	-1.0	-0.9	0.4	-1.1	1.1	1.1	1.0
Delay disc. indifference point, 8s delay	0.9	1.6	2.6	-1.6	-1.5	1.4	-1.4	1.2	0.7	0.4
Indifference point function ln k	0.1	0.3	0.6	-0.6	-0.7	0.8	-0.5	0.4	0.0	0.1
Indifference point function log k	0.1	0.3	0.6	-0.6	-0.7	0.8	-0.5	0.4	0.0	0.1
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.2	-0.3	-0.0	-0.4	0.6	0.6	0.6
Patch foraging total patch changes 12 sec	0.3	0.4	0.7	-0.6	-0.8	0.8	-0.8	0.6	0.5	0.4
Patch foraging total patch changes 18 sec	0.4	1.0	1.3	1.1	1.1	-0.9	1.1	-1.1	-0.8	-0.8
Patch foraging total patch changes 24 sec	0.0	0.1	0.2	0.5	0.3	-0.5	0.3	-0.2	-0.1	-0.1
Patch foraging total patch changes 6 sec	0.1	0.2	0.5	0.6	0.5	-0.7	0.5	-0.3	0.1	-0.1
Patch foraging time to switch 0 sec	0.6	2.3	5.8	0.2	0.1	-1.3	-0.9	1.6	2.4	2.3
Patch foraging water rate 0 sec	0.4	1.5	4.7	-1.1	-1.2	2.2	-0.4	-0.3	-1.4	-1.2
Patch foraging water rate 12 sec	0.8	3.1	7.6	-2.3	-2.3	2.8	-1.6	1.0	-0.4	-0.2
Patch foraging water rate 18 sec	1.4	3.2	8.8	-1.2	-1.4	3.0	-0.3	-0.7	-2.3	-2.1
Patch foraging water rate 24 sec	2.4	3.4	10.4	-2.2	-2.1	3.2	-1.2	0.2	-1.3	-1.2
Patch foraging water rate 6 sec	1.1	1.6	3.4	-0.8	-0.6	1.8	0.2	-0.9	-1.8	-1.8
Seeking ratio, delayed vs. immediate footshock	2.8	4.0	5.4	2.1	2.3	-1.7	2.3	-1.9	-1.8	-1.8
Distance traveled before self-admin	0.1	0.2	0.3	-0.5	-0.2	-0.1	-0.4	0.6	0.5	0.6
Distance traveled after self-admin	0.0	0.0	0.1	-0.0	0.3	-0.2	0.1	0.0	-0.1	-0.0
Extensor digitorum longus weight	3.6	14.4	20.0	-4.4	-4.5	3.9	-4.4	3.7	2.4	2.7
Bone: elastic displacement	0.0	0.1	0.1	-0.0	0.2	-0.2	0.3	-0.3	-0.2	-0.3
Bone: elastic work	0.3	0.4	0.6	-0.8	-0.7	0.3	-0.7	0.7	0.6	0.7
Bone: endosteal estimation	0.1	0.2	0.4	-0.4	-0.4	0.2	-0.5	0.5	0.5	0.6
Bone: endosteal perimeter	0.3	0.7	1.3	1.1	1.1	-1.0	0.9	-0.7	-0.1	-0.2
Epididymis fat weight	0.1	0.5	1.4	-0.0	-0.4	1.2	-0.1	-0.4	-0.9	-0.7
Delta time in closed arm before/after self-admin	2.3	2.2	6.5	-1.8	-1.7	2.5	-1.1	0.3	-0.8	-0.6
Delta time in open arm before/after self-admin	0.4	0.4	0.6	-0.8	-0.7	0.4	-0.7	0.7	0.6	0.6
Diff in mean of infusions in LGA sessions	1.1	2.0	2.5	1.5	1.5	-1.0	1.6	-1.5	-1.4	-1.3
Delay discount exponential model param	1.3	1.7	2.5	1.6	1.5	-1.1	1.5	-1.4	-1.1	-0.9
Extinction: sum of active levers before priming	0.6	0.9	1.6	0.8	0.7	-0.1	0.9	-1.0	-1.3	-1.2
Active lever presses in extinction session 6	1.7	1.7	2.7	1.5	1.6	-1.3	1.5	-1.3	-0.9	-0.9
Bone: final force	1.1	1.8	2.9	-0.9	-1.0	0.2	-1.4	1.6	1.7	1.6
Bone: final moment	0.9	1.4	2.4	-0.9	-0.9	0.2	-1.3	1.5	1.6	1.5
Food consumed during 24 hour testing period	0.4	0.8	1.3	-1.1	-1.1	1.0	-1.0	0.9	0.3	0.3
Glucose	2.6	4.1	6.0	-2.3	-2.4	1.7	-2.3	2.1	1.5	1.6
Heart weight	0.7	1.2	2.8	0.5	0.2	0.7	0.7	-1.3	-1.7	-1.5
Delay discount hyperbolic model param	2.2	2.9	3.9	1.9	1.9	-1.2	2.0	-1.9	-1.5	-1.4
Intermittent access intake day 1-15 change	0.9	5.0	7.1	1.9	2.2	-0.7	2.5	-2.7	-2.6	-2.6
Intermittent access intake escalation	0.8	4.4	6.3	1.8	2.0	-0.6	2.3	-2.5	-2.4	-2.5
Intermittent access intake escalation 2	2.4	4.0	5.5	1.8	2.0	-0.7	2.2	-2.3	-2.3	-2.2
Intermitt. access day 1 inactive lever presses	0.1	0.7	1.8	-0.3	-0.4	1.3	0.0	-0.6	-1.2	-1.0
Intermitt. access day 15 inactive lever presses	0.1	0.5	1.0	0.9	1.0	-0.6	0.8	-0.7	-0.3	-0.4
Intermitt. access escalation Index	0.4	1.1	2.5	-0.8	-0.3	-0.5	-0.8	1.2	1.6	1.6
Intermittent access day 1 total infusions	0.1	0.3	0.6	0.3	0.0	0.6	0.2	-0.6	-0.8	-0.7
Intermittent access day 15 total infusions	1.2	3.0	4.2	1.7	1.7	-0.4	1.8	-2.0	-1.9	-1.9
Intermittent access terminal intake (last 3 days)	1.1	1.9	2.6	1.6	1.5	-0.5	1.5	-1.6	-1.4	-1.4
Intermittent access total infusions	0.8	0.9	1.4	1.0	0.9	-0.1	1.0	-1.2	-1.0	-1.0
Intermittent access day 1 locomotion	1.0	1.8	3.6	1.1	0.8	0.4	1.2	-1.7	-1.9	-1.8
Intermittent access day 15 total locomotion	1.1	4.1	6.4	1.8	1.8	-0.5	2.3	-2.5	-2.3	-2.3
Intermittent access total locomotion	1.9	2.3	3.5	1.3	1.3	-0.2	1.6	-1.9	-1.8	-1.7
Intermittent access standard deviation	1.1	6.0	8.1	2.9	2.6	-1.4	2.8	-2.8	-2.1	-2.3
Left kidney weight	0.1	0.5	1.9	-0.5	-0.6	1.4	-0.3	-0.3	-0.9	-0.7
Right kidney weight	0.3	2.2	4.8	0.5	0.7	0.7	1.1	-1.8	-2.2	-2.2
Cocaine induced anxiety	0.8	2.2	4.8	1.9	1.9	-2.2	1.5	-0.9	-0.1	-0.2
Post-drug Anxiety	2.0	2.2	5.1	1.9	1.9	-2.3	1.5	-0.9	-0.2	-0.2
Baseline Anxiety	0.1	0.1	0.4	-0.0	0.1	0.2	0.2	-0.3	-0.7	-0.6
Tail length	2.0	10.5	14.1	3.0	3.4	-1.6	3.6	-3.8	-3.3	-3.6
Length with tail	1.6	6.9	9.0	2.6	2.8	-1.4	2.9	-3.0	-2.6	-2.8
Length without tail	0.0	0.0	0.1	-0.1	-0.2	0.3	-0.2	0.1	-0.1	-0.0
Times rat made contact with spout	0.5	0.6	1.5	-1.1	-0.9	1.2	-0.6	0.4	-0.3	-0.4
Lifetime Intake	0.4	0.5	0.8	0.8	0.7	0.1	0.7	-0.9	-0.8	-0.8
Liver weight, left	0.8	1.4	2.2	-1.4	-1.5	1.1	-1.3	1.2	0.6	0.9
Liver weight, right	0.7	1.1	2.2	-1.4	-1.3	1.5	-1.2	0.7	0.2	0.4
Locomotor activity	2.9	4.5	7.9	2.6	2.8	-2.6	2.3	-1.6	-0.7	-1.2
Locomotor testing distance	1.2	2.9	4.9	2.1	2.2	-2.2	1.9	-1.3	-0.7	-0.9
Locomotor testing rearing	0.1	0.2	0.5	-0.3	-0.3	0.7	-0.0	-0.2	-0.7	-0.7
Locomotion in novel chamber	0.6	0.8	1.4	0.6	0.6	-0.2	1.0	-1.0	-1.1	-1.2
Locomotion in novel chamber post-restriction	0.6	1.9	3.5	1.1	1.1	-0.2	1.3	-1.6	-1.9	-1.7
Fecal boli incidents, locomotor time 1	0.6	1.6	2.2	-1.2	-1.2	0.8	-1.4	1.5	1.2	1.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.5	0.5	-0.5	0.4	-0.3	-0.1	-0.2
Time >=10cm from walls, locomotor time 1	0.8	1.0	2.5	-0.5	-0.2	-0.7	-0.6	1.1	1.6	1.5
Bouts of movement, locomotor time 1	0.2	0.3	0.4	0.4	0.6	-0.0	0.6	-0.6	-0.6	-0.7
Total resting periods, locomotor time 1	0.3	0.4	0.5	0.6	0.7	-0.2	0.7	-0.7	-0.7	-0.6
Rest time, locomotor task time 1	0.3	0.5	1.0	0.9	1.0	-0.8	0.7	-0.5	-0.3	-0.2
Distance moved, locomotor task time 1	0.4	1.2	2.7	-0.7	-0.6	-0.5	-0.9	1.2	1.6	1.5
Vertical activity count, locomotor time 1	0.1	0.8	1.7	-1.3	-1.3	1.1	-0.8	0.5	0.1	0.0
Time >=10cm from walls, locomotor time 2	0.6	1.7	2.3	-1.5	-1.5	1.4	-1.5	1.4	0.8	0.8
Bouts of movement, locomotor time 2	0.2	0.8	2.1	1.1	1.2	-1.5	0.8	-0.5	0.3	-0.0
Total resting periods, locomotor time 2	0.2	0.8	2.3	1.1	1.2	-1.5	0.8	-0.4	0.4	0.1
Rest time, locomotor task time 2	0.5	0.9	1.6	1.2	1.3	-1.2	1.0	-0.7	-0.3	-0.4
Distance moved, locomotor task time 2	0.5	0.7	1.0	-0.9	-1.0	0.8	-0.9	0.8	0.6	0.6
Vertical activity count, locomotor time 2	0.4	0.9	2.2	-1.1	-1.2	1.5	-1.0	0.6	0.1	0.2
Light reinforcement 1	2.2	9.9	15.2	3.8	3.9	-3.2	3.6	-2.9	-2.0	-2.1
Light reinforcement 2	1.2	2.7	4.4	2.1	2.0	-1.8	1.9	-1.4	-0.9	-0.9
Bone: marrow area	0.1	0.2	0.4	-0.4	-0.4	0.2	-0.5	0.5	0.5	0.6
Bone: maximum diameter	0.9	1.9	4.1	2.0	1.7	-1.8	1.4	-0.9	-0.3	-0.4
Bone: maximum force	0.9	1.8	2.4	-1.1	-1.3	0.6	-1.5	1.6	1.5	1.5
Bone: maximum moment	0.8	1.5	2.0	-1.1	-1.2	0.6	-1.4	1.4	1.4	1.4
Mean time between licks in bursts	0.8	4.8	6.3	2.2	2.1	-1.2	2.5	-2.5	-2.2	-2.3
Mean num. licks in bursts	0.0	0.1	0.2	-0.4	0.1	-0.3	-0.1	0.3	0.2	0.3
Cd content in liver	0.1	0.1	0.3	0.1	0.4	-0.5	0.4	-0.0	-0.2	-0.3
Co content in liver	1.0	1.2	1.9	0.9	1.0	-0.4	1.3	-1.2	-1.3	-1.4
Cu content in liver	0.6	0.7	1.9	0.9	1.1	-1.4	0.6	-0.0	0.5	0.3
Fe content in liver	0.2	0.2	0.6	0.7	0.4	-0.0	0.4	-0.4	-0.4	-0.5
K content in liver	0.5	0.5	1.3	0.9	0.6	-1.1	0.3	0.2	0.7	0.5
Mg content in liver	0.3	0.3	0.7	0.6	0.6	-0.8	0.6	-0.3	-0.0	-0.1
Mn content in liver	2.2	2.5	5.9	2.1	2.1	-2.4	1.5	-0.8	0.3	-0.0
Na content in liver	1.1	1.2	3.2	0.2	-0.1	-0.8	-0.7	1.2	1.8	1.6
Rb content in liver	0.5	0.6	1.8	0.8	0.7	-1.4	0.3	0.4	0.8	0.7
Se content in liver	0.3	0.3	0.7	0.8	0.8	-0.4	0.6	-0.5	-0.3	-0.4
Sr content in liver	0.1	0.1	0.3	-0.3	-0.3	0.5	-0.2	-0.0	-0.3	-0.2
Zn content in liver	3.2	3.7	7.8	0.6	1.0	0.5	1.8	-2.4	-2.8	-2.8
Bone: minimum diameter	0.1	0.1	0.2	0.4	0.2	-0.4	-0.0	0.2	0.4	0.5
Time in familiar zone, hab. session 1	1.9	2.1	3.3	1.1	1.3	-0.2	1.4	-1.8	-1.7	-1.8
Time in novel zone, hab. session 1	1.2	1.3	2.7	-0.7	-0.7	-0.3	-1.0	1.4	1.5	1.7
Total zone transitions, hab. session 1	1.5	2.2	5.9	1.8	1.8	-2.4	1.4	-0.8	0.4	0.1
Total locomotion distance, hab. session 1	2.5	3.6	9.2	2.6	2.4	-3.0	1.6	-0.8	0.7	0.3
Locomotion velocity, hab. session 1	2.9	4.1	9.5	2.7	2.6	-3.1	1.9	-1.1	0.4	-0.1
Time in familiar zone, hab. session 2	5.3	6.0	9.1	2.2	2.1	-0.5	2.6	-2.9	-3.0	-2.9
Time in novel zone, hab. session 2	4.3	4.7	6.4	-2.4	-1.8	0.5	-2.2	2.5	2.5	2.4
Total zone transitions, hab. session 2	1.6	2.1	5.7	0.4	0.9	-2.4	0.1	0.9	2.1	1.7
Total locomotion distance, hab. session 2	1.9	2.5	6.9	1.7	2.2	-2.6	1.6	-0.8	0.3	-0.1
Locomotion velocity, hab. session 2	2.3	3.1	9.2	1.8	2.3	-3.0	1.6	-0.8	0.6	0.1
Novel to familiar place preference ratio	3.3	4.3	7.5	-1.7	-1.6	0.0	-2.0	2.4	2.7	2.7
Novelty place preference	2.1	2.7	5.0	-1.2	-1.1	-0.2	-1.5	1.9	2.2	2.2
Time in novel zone, NPP test	2.4	2.9	5.2	-1.4	-1.2	0.0	-1.7	2.0	2.2	2.3
Total zone transitions, NPP test	0.8	1.2	3.8	0.9	0.8	-2.0	0.3	0.4	1.4	1.1
Total locomotion distance, NPP test	0.8	1.2	3.4	1.0	0.9	-1.8	0.3	0.3	1.3	1.0
Locomotion velocity, NPP test	0.9	1.2	4.1	1.2	1.1	-2.0	0.6	0.1	1.1	0.7
Intraocular pressure	0.8	1.3	3.2	-1.3	-1.0	1.8	-0.3	-0.4	-1.3	-1.1
Delta distance traveled before/after self-admin	0.4	0.4	0.6	0.7	0.6	-0.2	0.7	-0.7	-0.8	-0.7
Delta ambulatory time before/after self-admin	0.2	0.4	0.7	0.8	0.8	-0.5	0.7	-0.6	-0.5	-0.5
Parametrial fat weight	0.0	0.1	0.3	-0.1	0.3	-0.5	0.1	0.1	0.3	0.4
Pavlov. Cond. lever latency	0.7	0.9	2.7	-1.0	-1.1	1.6	-0.4	-0.2	-1.0	-0.6
Pavlov. Cond. magazine entry latency	3.3	4.2	5.8	2.3	2.4	-1.5	2.3	-2.2	-1.7	-1.8
Pavlov. Cond. change in total contacts	0.2	0.3	0.7	0.8	0.8	-0.6	0.4	-0.2	0.0	-0.1
Pavlov. Cond. index score	0.9	1.2	2.4	1.4	1.6	-1.4	1.0	-0.7	-0.1	-0.3
Pavlov. Cond. latency score	1.1	1.4	3.0	1.6	1.7	-1.7	1.1	-0.6	0.2	-0.1
Pavlov. Cond. lever contacts	0.6	0.7	2.1	0.9	1.0	-1.4	0.3	0.2	0.9	0.6
Pavlov. Cond. magazine entry number	1.0	1.3	1.9	-1.3	-1.4	0.8	-1.2	1.2	1.0	1.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	-0.2	-0.3	0.8	0.2	-0.5	-0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	2.6	1.5	1.6	-1.3	1.1	-0.9	-0.3	-0.5
Pavlov. Cond. response bias	1.1	1.3	2.0	1.4	1.4	-0.9	1.2	-1.2	-0.9	-1.0
Pavlov. Cond. lever latency	0.5	0.6	1.4	-0.6	-0.5	0.1	-0.8	0.8	1.1	1.2
Pavlov. Cond. magazine entry latency	0.3	0.4	0.6	0.8	0.6	-0.2	0.7	-0.7	-0.7	-0.6
Pavlov. Cond. change in total contacts	0.2	0.5	1.3	0.5	0.2	0.1	0.6	-0.7	-1.1	-1.1
Pavlov. Cond. index score	0.4	0.6	1.2	0.6	0.4	0.0	0.7	-0.8	-1.1	-1.1
Pavlov. Cond. latency score	0.3	0.6	0.9	0.7	0.5	-0.2	0.8	-0.8	-0.9	-1.0
Pavlov. Cond. lever contacts	0.4	0.6	1.5	0.5	0.3	0.3	0.6	-0.7	-1.2	-1.2
Pavlov. Cond. magazine entry number	0.5	0.7	1.1	-1.0	-0.8	0.4	-0.9	0.9	0.9	0.8
Pavlov. Cond. intertrial magazine entries	0.3	0.6	1.2	-1.0	-1.0	1.1	-0.8	0.5	-0.2	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	1.0	0.8	0.6	-0.2	0.8	-0.8	-1.0	-1.0
Pavlov. Cond. response bias	1.2	1.6	3.4	0.8	0.7	0.1	1.2	-1.3	-1.8	-1.8
Time in closed arm before self-admin	0.4	0.6	1.4	0.1	-0.0	-0.8	-0.4	0.9	1.2	1.2
Time in closed arm after self-admin	0.3	0.3	1.1	0.1	0.0	0.4	0.3	-0.5	-1.1	-0.9
Time in open arm before self-admin	0.1	0.1	0.2	0.4	0.4	-0.3	0.3	-0.2	0.1	0.0
Time in open arm after self-admin	0.9	1.0	1.3	-1.1	-1.0	0.7	-1.1	1.0	1.1	1.0
Bone: periosteal estimation	0.2	0.6	1.3	0.1	-0.1	-0.5	-0.5	0.9	1.1	1.2
Bone: periosteal perimeter	0.2	0.5	1.2	0.9	0.8	-1.1	0.5	-0.1	0.4	0.3
Bone: post-yield work	0.4	0.7	1.0	-0.9	-1.0	0.9	-1.0	0.9	0.6	0.6
Progressive ratio test 1 active lever presses	0.2	0.4	1.2	0.1	-0.2	1.1	0.1	-0.6	-0.9	-0.7
Progressive ratio test 1 breakpoint	0.2	0.4	1.2	0.1	-0.3	1.1	0.0	-0.6	-0.9	-0.7
Progressive ratio test 1 inactive lever presses	0.2	0.4	0.9	0.6	0.5	0.2	0.6	-0.8	-0.9	-0.7
Progressive ratio test 2 active lever presses	0.4	0.5	1.3	0.1	-0.1	1.2	0.2	-0.7	-1.0	-0.9
Progressive ratio test 2 breakpoint	0.4	0.6	1.2	0.2	-0.1	1.1	0.3	-0.8	-1.0	-0.9
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.6	0.8	0.6	-0.1	0.4	-0.4	-0.1	-0.1
Incentive Sensitization - Responses	0.1	0.3	1.5	-0.6	-0.6	1.2	-0.4	-0.1	-0.3	-0.2
Incentive Sensitization - Breakpoint	0.1	0.2	1.0	-0.5	-0.4	1.0	-0.2	-0.2	-0.4	-0.3
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.1	0.2	-0.1	0.1
Progressive ratio	0.1	0.2	0.4	-0.5	-0.5	0.6	-0.5	0.2	0.5	0.3
Food seeking constrained by brief footshock	0.5	0.7	1.4	1.1	1.2	-1.0	0.8	-0.5	-0.2	-0.0
Seeking ratio, punishment vs. effort	0.3	0.6	1.2	1.0	1.1	-1.1	0.8	-0.4	-0.4	-0.2
Retroperitoneal fat weight	0.4	1.6	3.2	-1.7	-1.5	1.8	-1.4	0.9	0.1	0.4
Reaction time number correct	0.6	2.0	5.3	-1.9	-1.6	2.3	-1.1	0.5	-0.7	-0.6
Reaction time mean minus median	0.1	0.5	1.0	0.7	0.3	0.0	0.7	-1.0	-1.0	-0.9
Reaction time mean minus median AUC	0.0	0.1	0.4	0.4	0.2	-0.6	0.1	0.1	0.4	0.5
Reaction time num false alarms	0.5	0.8	2.5	-1.0	-1.1	1.6	-0.7	0.1	-0.2	-0.4
Reaction time num false alarms AUC	0.4	1.0	3.0	-1.1	-1.2	1.7	-0.7	0.1	-0.3	-0.5
Reaction time trials correct on left	0.6	2.0	5.3	-1.9	-1.6	2.3	-1.1	0.5	-0.7	-0.6
Reaction time trials on left	0.6	1.9	5.0	-1.9	-1.6	2.2	-1.1	0.5	-0.7	-0.5
Reaction time mean	0.1	0.1	0.3	-0.1	-0.3	-0.2	-0.2	0.4	0.5	0.5
Reaction time mean AUC	0.1	0.2	0.4	-0.2	-0.4	-0.2	-0.3	0.4	0.6	0.6
Median of all reaction times	0.3	0.5	1.1	-0.4	-0.5	-0.2	-0.6	0.9	1.0	1.0
Reaction time omissions	0.1	0.2	0.9	0.3	0.5	-0.9	0.5	-0.2	0.1	0.1
Reaction time false alarm rate	0.1	0.1	0.1	-0.1	-0.3	0.3	-0.3	0.1	0.4	0.2
Reaction time premature initiation rate	0.7	1.1	1.9	0.7	0.6	0.1	1.0	-1.4	-1.4	-1.4
Reaction time premature initiations	0.5	1.5	3.7	-0.3	-0.2	1.3	0.6	-1.2	-1.9	-1.8
Std. dev. reaction times	0.0	0.1	0.2	0.4	0.0	-0.1	0.3	-0.4	-0.3	-0.2
Reaction time trials completed	0.6	1.9	5.0	-1.9	-1.6	2.2	-1.1	0.5	-0.7	-0.5
Reaction time trials AUC	0.6	2.2	6.1	-2.0	-1.7	2.5	-1.1	0.4	-0.8	-0.7
Run reversals in cocaine runway, females	0.6	0.7	1.2	1.0	1.1	-1.0	0.9	-0.8	-0.3	-0.3
Run reversals in cocaine runway, males	1.8	2.0	2.8	1.6	1.7	-1.4	1.5	-1.3	-1.2	-1.0
Latency to leave start box in cocaine runway	0.4	0.6	2.1	0.9	0.8	-1.5	0.7	-0.1	0.4	0.2
Latency to leave start box in cocaine runway, F	0.8	1.0	2.4	0.4	0.3	-1.5	-0.0	0.8	1.4	1.3
Latency to leave start box in cocaine runway, M	1.4	1.4	2.3	1.0	0.8	-0.2	1.3	-1.4	-1.4	-1.5
Std. dev. time between licks in bursts	0.3	0.6	0.8	0.9	0.8	-0.8	0.9	-0.8	-0.4	-0.6
Total sessions with >9 infusions	0.3	0.3	0.7	0.5	0.2	0.5	0.3	-0.7	-0.9	-0.7
Short access day 1 total inactive lever presses	0.2	0.3	0.6	0.7	0.6	-0.2	0.6	-0.8	-0.5	-0.5
Short access day 10 total inactive lever presses	0.0	0.2	0.4	-0.5	-0.3	0.7	-0.2	-0.0	-0.4	-0.5
Short access day 1 total infusions	0.2	0.5	0.9	0.9	0.8	-0.3	0.7	-0.8	-0.6	-0.4
Short access day 10 total infusions	0.2	0.3	0.5	0.3	-0.0	0.7	0.1	-0.5	-0.7	-0.6
Short access total infusions	0.2	0.3	0.5	0.7	0.5	0.2	0.5	-0.7	-0.7	-0.6
Short access day 1 locomotion	0.9	1.5	2.1	1.4	1.2	-0.4	1.3	-1.4	-1.4	-1.2
Short access day 10 total locomotion	1.5	6.0	9.4	2.2	1.8	-0.1	2.5	-3.0	-3.1	-3.0
Short access total locomotion	1.5	2.3	3.6	1.6	1.2	-0.2	1.5	-1.8	-1.9	-1.7
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.1	-0.3	0.6	-0.2	-0.1	-0.1	-0.1
Compulsive drug intake	1.0	1.4	3.1	-0.7	-0.5	-0.7	-1.0	1.5	1.8	1.6
One hour access (shock baseline)	0.3	0.8	1.5	0.7	0.3	0.7	0.6	-1.1	-1.2	-1.2
Social response proportion	0.8	1.0	1.9	1.1	1.2	-1.4	1.1	-0.7	-0.1	-0.4
Social responses	5.8	7.6	10.8	3.3	3.2	-2.5	3.2	-2.7	-1.8	-2.2
Social time	0.3	0.5	0.9	-0.8	-0.6	0.2	-0.7	0.9	0.7	0.7
Soleus weight	6.9	20.3	27.4	-4.9	-4.9	3.3	-5.2	4.9	3.8	4.2
Bone: stiffness	1.8	3.2	4.9	-1.0	-1.6	0.7	-2.0	2.2	2.1	2.2
Tibialis anterior weight	0.8	2.8	4.0	-1.8	-1.8	1.4	-2.0	1.9	1.2	1.4
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.4	0.4	0.6	-0.6	0.4	-0.2	-0.3	-0.2
Time to tail flick, vehicle, after self-admin	0.4	0.8	2.0	0.1	0.1	1.0	0.4	-0.9	-1.4	-1.3
Time to tail flick, test, before self-admin	0.4	0.4	1.1	0.9	0.8	-1.0	0.6	-0.4	0.1	0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	0.3	-0.2	0.4	-0.4	-0.5	-0.4
Delta time to tail flick, vehicle, before/after SA	0.6	0.7	2.6	-0.8	-0.8	1.6	-0.5	0.0	-0.5	-0.4
Delta time to tail flick, test, before/after SA	0.4	0.4	1.1	-0.5	-0.4	1.1	-0.1	-0.3	-0.9	-0.8
Tibia length	0.6	1.7	2.3	1.3	1.3	-0.6	1.5	-1.4	-1.2	-1.5
Ambulatory time before self-admin	0.1	0.2	0.3	-0.5	-0.3	-0.0	-0.5	0.6	0.5	0.5
Ambulatory time after self-admin	0.0	0.0	0.1	0.0	0.3	-0.3	-0.0	0.1	0.1	0.2
Bone: tissue strength	1.7	1.7	2.6	-1.3	-1.2	0.4	-1.4	1.6	1.5	1.4
Total heroin consumption	1.5	1.7	2.4	1.5	1.5	-1.3	1.5	-1.3	-1.0	-1.0
Bone: trabecular number	0.7	1.4	3.2	1.6	1.5	-1.8	1.0	-0.4	0.5	0.3
Bone: trabecular spacing	1.6	2.3	6.7	-1.8	-1.8	2.6	-1.0	0.2	-1.0	-0.8
Bone: trabecular thickness	2.0	2.8	7.2	0.9	1.2	-2.7	0.1	1.1	2.3	1.8
Bone: trabecular tissue density	0.9	1.6	2.8	-1.7	-1.4	1.2	-1.5	1.3	0.8	0.8
Water consumed over 24 hours	0.4	0.8	1.6	-0.7	-0.7	0.2	-1.0	1.3	1.0	0.9
Number of responses in last shaping day	1.3	1.7	3.0	1.1	1.1	0.1	1.2	-1.6	-1.7	-1.6