LOC134479803

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	LOC134479803	0.34	0.14	0.0e+00	0.26	0.31	0.31	0.31	4.3e-29	5.2e-35	3.3e-35	2.2e-35
2	Liver	isoform ratio	XM_063264471.1	0.61	0.2	0.0e+00	0.3	0.28	0.3	0.3	2.8e-34	1.9e-31	3.8e-33	6.6e-34
3	Liver	isoform ratio	XM_063264472.1	0.46	0.22	0.0e+00	0.28	0.26	0.27	0.27	1.4e-30	2.8e-28	1.5e-29	3.8e-30
4	Liver	intron excision ratio	chr7_1008057_1010740	0.75	0.13	0.0e+00	0.42	0.39	0.43	0.42	5.6e-50	3.5e-46	2.7e-51	3.6e-50
5	Liver	intron excision ratio	chr7_1010903_1014127	0.79	0.09	0.0e+00	0.39	0.37	0.41	0.4	5.0e-46	7.7e-43	9.3e-49	1.8e-47
6	Liver	intron excision ratio	chr7_1017346_1026966	0.59	0.18	0.0e+00	0.38	0.4	0.42	0.41	3.6e-45	6.8e-47	1.7e-50	1.4e-48
7	Liver	gene expression	LOC134479803	0.48	0.14	0.0e+00	0.28	0.28	0.31	0.3	1.3e-31	8.4e-32	6.1e-35	2.7e-34
8	Liver	intron excision ratio	chr7_1017346_1026327	0.65	0.16	0.0e+00	0.36	0.39	0.41	0.4	2.5e-42	9.2e-46	2.9e-49	6.5e-48

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	1.1	1.9	3.6	-0.2	1.0	-1.0	-1.3	1.4	-1.7	1.7	1.9
Area under the delay curve	0.0	0.0	0.1	-0.0	0.1	-0.1	-0.2	0.2	-0.1	0.2	0.1
BMI with tail	7.1	24.5	30.6	-5.5	5.3	-5.3	-5.0	4.9	-4.6	4.6	4.4
BMI without tail	1.5	4.6	6.6	-2.6	2.5	-2.5	-2.2	2.1	-1.6	1.7	1.6
Body weight	0.6	2.7	4.6	-2.1	2.0	-2.0	-1.7	1.5	-1.2	1.2	1.0
Weight adjusted by age	0.1	0.1	0.3	0.2	-0.3	0.3	0.4	-0.4	0.4	-0.6	-0.4
Bone surface	1.3	2.3	4.9	0.2	0.9	-0.9	-1.3	1.6	-1.9	2.1	2.2
Bone volume	1.8	3.1	6.3	-0.1	1.2	-1.2	-1.6	1.9	-2.2	2.3	2.5
Breakpoint value in progressive ratio session	0.9	1.0	1.2	1.1	-1.1	1.1	1.1	-1.0	1.0	-0.9	-0.9
Number of licking bursts	1.0	1.7	3.9	-2.0	1.6	-1.6	-1.3	1.2	-0.9	0.8	0.6
Context. condit. distance diff. score	0.2	0.2	0.5	-0.7	0.6	-0.6	-0.4	0.4	-0.1	0.1	0.1
Locomotion velocity, session 1	0.4	0.5	0.8	-0.2	0.5	-0.5	-0.6	0.7	-0.8	0.8	0.9
Locomotion distance, session 1	0.2	0.2	0.6	0.4	0.1	-0.1	-0.2	0.4	-0.6	0.7	0.8
Locomotion velocity, session 2	0.2	0.3	1.3	1.2	-0.6	0.6	0.4	-0.2	0.1	-0.1	0.1
Locomotion distance, session 2	1.2	1.7	4.5	2.1	-1.5	1.5	1.2	-1.1	0.9	-0.9	-0.6
Locomotion velocity, session 3	4.3	4.9	6.2	2.4	-2.5	2.5	2.3	-2.2	1.9	-1.9	-1.9
Locomotion distance, session 3	0.2	0.2	0.3	0.4	-0.4	0.4	0.5	-0.5	0.5	-0.5	-0.5
Stereotopy head waving bouts, day 3	3.9	4.6	6.8	2.6	-2.5	2.5	2.2	-2.1	1.7	-1.6	-1.6
Stereotopy head waving duration, day 3	2.0	2.4	3.9	2.0	-1.9	1.9	1.6	-1.5	1.0	-1.0	-0.9
Locomotion velocity, session 7	0.0	0.0	0.1	0.1	-0.0	0.0	-0.1	0.1	-0.2	0.2	0.2
Locomotion distance, session 7	0.0	0.0	0.2	-0.4	0.1	-0.1	0.0	-0.1	0.2	-0.2	-0.3
Stereotopy head waving bouts, day 7	0.3	0.3	0.9	1.0	-0.7	0.7	0.5	-0.4	0.1	-0.0	0.0
Stereotopy head waving duration, day 7	0.2	0.2	1.0	1.0	-0.6	0.6	0.4	-0.2	0.0	-0.0	0.2
Locomotion velocity, session 8	0.3	0.4	1.5	1.2	-0.8	0.8	0.6	-0.4	0.2	-0.2	0.0
Locomotion distance, session 8	0.3	0.4	0.6	0.8	-0.6	0.6	0.6	-0.6	0.6	-0.7	-0.5
Degree of sensitization distance	0.7	0.7	1.0	-1.0	0.9	-0.9	-0.9	0.8	-0.8	0.8	0.7
Degree of sensitization stereotypy	0.3	0.3	0.7	-0.3	0.4	-0.4	-0.5	0.6	-0.7	0.7	0.8
Conditioned locomotion	0.1	0.1	0.7	-0.8	0.4	-0.4	-0.2	0.1	-0.0	-0.1	-0.1
Cocaine response after cond. corrected	1.1	1.3	3.2	-1.8	1.1	-1.1	-1.0	1.0	-1.1	0.9	0.9
Cocaine response after cond. not corrected	1.1	1.3	3.1	-1.8	1.1	-1.1	-1.0	0.9	-1.1	0.9	0.9
Cocaine response before conditioning	0.3	0.3	0.8	0.9	-0.7	0.7	0.6	-0.5	0.5	-0.4	-0.3
Saline control response	0.1	0.1	0.3	-0.5	0.5	-0.5	-0.3	0.2	-0.0	-0.1	0.0
Bone: connectivity density	0.7	1.0	2.2	-0.2	0.6	-0.6	-0.9	1.0	-1.3	1.3	1.5
Bone: cortical apparent density	1.2	1.6	2.2	-1.4	1.5	-1.5	-1.3	1.3	-1.1	1.0	1.1
Bone: cortical area	2.3	3.6	4.6	-1.2	1.7	-1.7	-1.9	2.0	-2.0	2.1	2.1
Bone: cortical porosity	0.2	0.2	0.4	-0.1	0.4	-0.4	-0.5	0.6	-0.6	0.5	0.7
Bone: cortical porosity	0.9	0.9	1.4	-0.5	0.9	-0.9	-1.0	1.1	-1.1	1.0	1.2
Bone: cortical thickness	2.3	3.8	4.5	-1.6	2.1	-2.1	-2.1	2.1	-1.9	1.7	2.0
Bone: cortical thickness	0.3	0.3	0.7	-0.8	0.8	-0.8	-0.6	0.5	-0.3	0.2	0.3
Bone: cortical tissue density	0.8	1.1	1.5	-1.1	1.2	-1.2	-1.1	1.1	-0.9	0.8	0.9
Condit. Reinf. active minus inactive responses	1.0	1.2	1.8	1.3	-1.4	1.4	1.1	-1.1	0.7	-0.7	-0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.2	-0.6	0.6	0.3	-0.3	-0.2	0.1	0.1
Condit. Reinf. active responses	1.5	1.8	3.2	1.8	-1.5	1.5	1.3	-1.2	1.1	-1.1	-1.0
Condit. Reinf. inactive responses	1.1	1.4	2.4	1.5	-1.0	1.0	1.0	-1.0	1.3	-1.3	-1.2
Incentive salience index mean	0.4	0.5	1.3	1.1	-0.9	0.9	0.7	-0.6	0.4	-0.4	-0.2
Condit. Reinf. lever presses	0.1	0.1	0.5	0.7	-0.2	0.2	-0.1	0.2	-0.3	0.3	0.6
Condit. Reinf. active minus inactive responses	2.9	3.7	4.0	1.7	-2.0	2.0	2.0	-2.0	1.9	-1.8	-1.9
Condit. Reinf. active-inactive response ratio	1.6	1.8	2.2	0.8	-1.4	1.4	1.4	-1.5	1.3	-1.3	-1.5
Condit. Reinf. active responses	1.6	2.2	2.5	1.5	-1.6	1.6	1.5	-1.5	1.4	-1.4	-1.4
Condit. Reinf. inactive responses	0.2	0.2	0.4	0.6	-0.4	0.4	0.4	-0.4	0.5	-0.4	-0.4
Condit. Reinf. lever presses	3.4	4.6	5.2	2.0	-2.1	2.1	2.2	-2.2	2.3	-2.2	-2.3
Condit. Reinf. lever reinforcers received	1.5	2.1	2.2	1.3	-1.5	1.5	1.5	-1.5	1.5	-1.5	-1.5
Conditioned reinforcement - actives	0.0	0.1	0.1	-0.3	0.3	-0.3	-0.3	0.3	-0.3	0.1	0.3
Conditioned reinforcement - inactives	0.2	0.3	0.8	-0.9	0.6	-0.6	-0.5	0.5	-0.3	0.2	0.3
Conditioned locomotion	0.8	1.1	1.9	1.4	-1.1	1.1	1.0	-0.9	0.9	-0.9	-0.7
Patch foraging indifference point 0 sec	4.1	7.5	8.0	-2.7	2.8	-2.8	-2.8	2.8	-2.7	2.6	2.7
Patch foraging indifference point AUC	0.6	0.9	1.3	0.9	-1.1	1.1	1.0	-1.0	0.8	-0.7	-0.8
Delay disc. indifference point, 0s delay	2.7	3.0	3.8	-1.2	1.7	-1.7	-1.8	1.8	-1.8	1.8	1.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	0.5	-0.4	0.4	0.3	-0.3	0.3	-0.2	-0.3
Delay disc. indifference point, 2s delay	0.6	0.6	1.0	-0.4	0.7	-0.7	-0.8	0.8	-0.9	1.0	0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.3	0.4	-0.4	-0.4	0.4	-0.4	0.4	0.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.6	-0.2	0.2	0.1	-0.0	-0.0	0.1	0.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.0	0.0	0.1	-0.1	-0.2
Indifference point function ln k	0.1	0.2	0.3	-0.4	0.4	-0.4	-0.5	0.5	-0.5	0.4	0.5
Indifference point function log k	0.1	0.2	0.3	-0.4	0.4	-0.4	-0.5	0.5	-0.5	0.4	0.5
Patch foraging total patch changes 0 sec	3.6	6.8	7.1	-2.6	2.7	-2.7	-2.6	2.6	-2.6	2.5	2.6
Patch foraging total patch changes 12 sec	1.2	1.6	2.7	-1.6	1.4	-1.4	-1.3	1.2	-1.0	1.0	0.9
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	-0.2	0.2	-0.2	-0.2	0.2	-0.3	0.3	0.3
Patch foraging total patch changes 24 sec	0.5	0.9	1.3	-0.8	0.9	-0.9	-0.9	0.9	-1.0	1.1	0.9
Patch foraging total patch changes 6 sec	2.1	3.2	3.6	-1.9	1.9	-1.9	-1.8	1.8	-1.7	1.6	1.6
Patch foraging time to switch 0 sec	0.2	0.5	0.6	-0.5	0.8	-0.8	-0.7	0.8	-0.7	0.7	0.8
Patch foraging water rate 0 sec	0.1	0.3	0.9	-1.0	0.6	-0.6	-0.5	0.4	-0.3	0.2	0.2
Patch foraging water rate 12 sec	0.3	0.6	1.4	-1.2	0.7	-0.7	-0.7	0.7	-0.8	0.6	0.7
Patch foraging water rate 18 sec	0.5	0.7	1.4	-0.1	-0.6	0.6	0.8	-0.9	1.0	-1.0	-1.2
Patch foraging water rate 24 sec	0.3	0.4	1.8	-1.3	0.6	-0.6	-0.3	0.1	0.3	-0.5	-0.5
Patch foraging water rate 6 sec	0.7	1.0	1.4	0.5	-1.0	1.0	1.1	-1.1	1.0	-1.1	-1.2
Seeking ratio, delayed vs. immediate footshock	0.5	0.7	1.3	1.1	-0.9	0.9	0.8	-0.8	0.7	-0.4	-0.6
Distance traveled before self-admin	1.1	1.5	1.9	1.4	-1.3	1.3	1.2	-1.2	1.1	-1.0	-1.0
Distance traveled after self-admin	0.0	0.0	0.0	0.2	-0.2	0.2	0.2	-0.2	0.1	-0.1	-0.1
Extensor digitorum longus weight	3.6	14.0	21.5	-4.6	4.2	-4.2	-3.8	3.6	-3.2	3.1	3.0
Bone: elastic displacement	0.0	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.0	-0.0	0.1
Bone: elastic work	1.1	1.5	1.7	-1.0	1.3	-1.3	-1.3	1.3	-1.1	1.1	1.2
Bone: endosteal estimation	1.0	2.2	3.1	-1.3	1.4	-1.4	-1.5	1.5	-1.5	1.8	1.5
Bone: endosteal perimeter	0.1	0.3	0.5	0.6	-0.2	0.2	-0.1	0.2	-0.7	0.7	0.7
Epididymis fat weight	0.2	0.7	1.0	0.3	-0.8	0.8	0.8	-0.9	0.9	-0.9	-1.0
Delta time in closed arm before/after self-admin	0.3	0.3	1.7	-1.3	0.6	-0.6	-0.4	0.2	-0.1	0.2	-0.2
Delta time in open arm before/after self-admin	0.4	0.4	0.6	-0.8	0.7	-0.7	-0.7	0.7	-0.6	0.5	0.6
Diff in mean of infusions in LGA sessions	1.8	2.2	2.6	1.5	-1.6	1.6	1.5	-1.5	1.4	-1.4	-1.4
Delay discount exponential model param	0.0	0.0	0.0	-0.1	0.0	-0.0	0.0	-0.0	0.0	-0.1	-0.0
Extinction: sum of active levers before priming	2.3	2.5	2.8	1.3	-1.6	1.6	1.6	-1.7	1.6	-1.6	-1.6
Active lever presses in extinction session 6	0.1	0.1	0.2	0.4	-0.3	0.3	0.2	-0.2	0.1	-0.2	-0.1
Bone: final force	4.3	6.9	7.5	-2.3	2.6	-2.6	-2.7	2.7	-2.6	2.7	2.6
Bone: final moment	4.2	6.7	7.4	-2.2	2.6	-2.6	-2.7	2.7	-2.6	2.6	2.6
Food consumed during 24 hour testing period	0.2	0.3	0.5	-0.5	0.7	-0.7	-0.6	0.5	-0.2	0.2	0.2
Glucose	1.2	1.8	2.1	-1.5	1.3	-1.3	-1.3	1.3	-1.4	1.4	1.3
Heart weight	0.3	0.4	0.6	0.6	-0.8	0.8	0.7	-0.7	0.5	-0.6	-0.6
Delay discount hyperbolic model param	0.1	0.2	0.3	0.2	-0.4	0.4	0.4	-0.4	0.4	-0.5	-0.4
Intermittent access intake day 1-15 change	0.4	0.9	1.0	0.7	-0.9	0.9	1.0	-1.0	1.0	-0.9	-1.0
Intermittent access intake escalation	0.4	0.8	1.0	0.7	-0.9	0.9	1.0	-1.0	1.0	-1.0	-1.0
Intermittent access intake escalation 2	0.8	0.9	1.0	0.9	-1.0	1.0	1.0	-1.0	0.9	-0.8	-0.9
Intermitt. access day 1 inactive lever presses	0.5	1.9	2.8	0.6	-1.2	1.2	1.4	-1.5	1.6	-1.6	-1.7
Intermitt. access day 15 inactive lever presses	0.8	1.6	2.2	1.1	-1.2	1.2	1.2	-1.2	1.3	-1.5	-1.3
Intermitt. access escalation Index	0.2	0.3	0.4	-0.1	0.5	-0.5	-0.6	0.6	-0.6	0.6	0.7
Intermittent access day 1 total infusions	0.1	0.2	0.3	-0.6	0.4	-0.4	-0.4	0.4	-0.3	0.3	0.3
Intermittent access day 15 total infusions	0.0	0.0	0.0	-0.2	0.2	-0.2	-0.2	0.2	-0.2	0.1	0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.0	0.2	-0.2	-0.3	0.3	-0.4	0.3	0.4
Intermittent access total infusions	0.3	0.3	0.4	-0.5	0.5	-0.5	-0.6	0.6	-0.6	0.4	0.6
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.2	-0.1	0.1	0.2	-0.2	0.3	-0.4	-0.4
Intermittent access day 15 total locomotion	0.1	0.3	0.4	0.3	-0.5	0.5	0.5	-0.5	0.5	-0.6	-0.6
Intermittent access total locomotion	0.1	0.1	0.2	0.2	-0.4	0.4	0.4	-0.4	0.4	-0.4	-0.4
Intermittent access standard deviation	0.2	0.3	0.8	0.9	-0.6	0.6	0.5	-0.5	0.4	-0.5	-0.3
Left kidney weight	0.0	0.1	0.3	0.2	-0.2	0.2	0.3	-0.4	0.5	-0.4	-0.6
Right kidney weight	0.4	1.7	2.3	1.0	-1.1	1.1	1.2	-1.3	1.5	-1.5	-1.5
Cocaine induced anxiety	0.4	0.6	1.9	1.4	-0.9	0.9	0.8	-0.7	0.5	-0.3	-0.3
Post-drug Anxiety	0.2	0.2	0.6	0.8	-0.2	0.2	-0.0	0.2	-0.4	0.7	0.6
Baseline Anxiety	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.2	0.2	-0.2	0.3	0.2
Tail length	4.3	16.7	18.4	4.0	-4.0	4.0	4.0	-4.0	4.3	-4.2	-4.2
Length with tail	2.1	9.3	10.8	2.8	-2.9	2.9	3.0	-3.0	3.3	-3.3	-3.3
Length without tail	0.1	0.3	0.7	-0.8	0.6	-0.6	-0.6	0.5	-0.5	0.5	0.4
Times rat made contact with spout	0.5	0.6	1.3	-1.2	0.9	-0.9	-0.8	0.7	-0.6	0.5	0.5
Lifetime Intake	1.2	1.5	1.6	-1.2	1.2	-1.2	-1.3	1.3	-1.3	1.1	1.3
Liver weight, left	0.2	0.3	0.5	-0.7	0.7	-0.7	-0.7	0.6	-0.4	0.3	0.4
Liver weight, right	0.3	0.6	0.9	0.5	-0.8	0.8	0.8	-0.8	0.9	-0.8	-0.9
Locomotor activity	2.4	3.7	6.6	2.6	-2.0	2.0	1.9	-1.8	1.7	-1.7	-1.5
Locomotor testing distance	0.8	1.5	2.9	1.7	-1.3	1.3	1.2	-1.1	1.0	-0.9	-0.8
Locomotor testing rearing	0.1	0.2	0.4	0.3	-0.3	0.3	0.4	-0.5	0.7	-0.6	-0.7
Locomotion in novel chamber	0.1	0.1	0.1	-0.3	0.4	-0.4	-0.3	0.3	-0.3	0.3	0.2
Locomotion in novel chamber post-restriction	3.1	5.1	6.8	2.6	-2.5	2.5	2.3	-2.2	2.0	-1.7	-2.0
Fecal boli incidents, locomotor time 1	0.2	0.2	0.7	-0.8	0.5	-0.5	-0.4	0.4	-0.4	0.4	0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.5	0.7	-0.3	0.3	0.2	-0.1	0.2	-0.1	0.0
Time >=10cm from walls, locomotor time 1	1.1	1.2	1.6	-0.7	1.0	-1.0	-1.1	1.2	-1.2	1.2	1.2
Bouts of movement, locomotor time 1	0.7	0.8	1.0	0.9	-0.9	0.9	0.9	-0.9	0.9	-1.0	-0.9
Total resting periods, locomotor time 1	1.4	1.6	1.8	1.3	-1.3	1.3	1.2	-1.2	1.2	-1.2	-1.2
Rest time, locomotor task time 1	0.3	0.4	0.8	0.9	-0.7	0.7	0.6	-0.5	0.5	-0.5	-0.4
Distance moved, locomotor task time 1	1.1	1.6	2.0	-1.0	1.3	-1.3	-1.3	1.3	-1.3	1.3	1.4
Vertical activity count, locomotor time 1	0.6	1.4	1.9	-1.4	1.3	-1.3	-1.2	1.1	-1.1	1.0	1.0
Time >=10cm from walls, locomotor time 2	0.5	0.8	1.4	-1.2	1.0	-1.0	-0.9	0.8	-0.7	0.8	0.6
Bouts of movement, locomotor time 2	0.0	0.0	0.3	0.5	-0.1	0.1	-0.0	0.1	-0.0	-0.0	0.1
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.5	0.0	-0.0	-0.1	0.2	-0.2	0.1	0.3
Rest time, locomotor task time 2	0.0	0.0	0.1	0.3	-0.0	0.0	-0.1	0.1	-0.2	0.2	0.3
Distance moved, locomotor task time 2	0.1	0.1	0.3	-0.2	-0.1	0.1	0.2	-0.3	0.4	-0.5	-0.4
Vertical activity count, locomotor time 2	0.3	0.4	1.4	-1.2	0.8	-0.8	-0.6	0.5	-0.4	0.2	0.2
Light reinforcement 1	1.9	4.8	7.6	2.8	-2.3	2.3	2.1	-2.0	2.0	-2.1	-1.7
Light reinforcement 2	0.9	1.4	2.0	1.4	-1.1	1.1	1.1	-1.0	1.2	-1.4	-1.1
Bone: marrow area	0.9	2.0	2.9	-1.2	1.3	-1.3	-1.4	1.4	-1.4	1.7	1.4
Bone: maximum diameter	0.2	0.4	0.9	0.5	-0.1	0.1	-0.2	0.4	-0.8	1.0	0.9
Bone: maximum force	4.1	7.3	8.0	-2.3	2.7	-2.7	-2.8	2.8	-2.8	2.8	2.8
Bone: maximum moment	4.1	7.2	7.8	-2.3	2.7	-2.7	-2.8	2.8	-2.7	2.8	2.7
Mean time between licks in bursts	0.5	1.2	1.6	0.9	-1.0	1.0	1.1	-1.1	1.2	-1.3	-1.2
Mean num. licks in bursts	0.3	0.4	1.0	1.0	-0.8	0.8	0.7	-0.6	0.4	-0.5	-0.3
Cd content in liver	0.0	0.1	0.1	0.4	-0.2	0.2	0.3	-0.2	0.1	-0.1	-0.1
Co content in liver	3.3	3.9	4.4	2.1	-1.9	1.9	2.0	-2.0	1.9	-2.1	-1.8
Cu content in liver	1.0	1.2	1.6	-0.8	1.1	-1.1	-1.1	1.1	-1.0	1.3	1.1
Fe content in liver	0.1	0.1	0.4	-0.7	0.5	-0.5	-0.3	0.3	-0.2	0.2	0.1
K content in liver	0.3	0.3	0.8	0.9	-0.5	0.5	0.5	-0.5	0.5	-0.4	-0.4
Mg content in liver	0.8	0.8	1.3	1.2	-0.9	0.9	0.9	-0.8	0.9	-0.8	-0.8
Mn content in liver	0.3	0.3	1.6	1.3	-0.6	0.6	0.4	-0.2	0.0	0.2	0.3
Na content in liver	0.5	0.6	1.4	-0.3	0.4	-0.4	-0.6	0.6	-0.9	1.2	1.0
Rb content in liver	0.7	0.8	1.3	-0.6	0.8	-0.8	-1.0	1.0	-0.9	1.1	0.9
Se content in liver	0.0	0.0	0.0	-0.0	-0.1	0.1	0.1	-0.0	-0.1	0.2	0.0
Sr content in liver	0.3	0.3	0.6	0.4	-0.4	0.4	0.5	-0.5	0.5	-0.8	-0.6
Zn content in liver	4.6	5.1	6.4	1.8	-2.2	2.2	2.3	-2.3	2.4	-2.4	-2.5
Bone: minimum diameter	1.0	1.8	2.8	-0.7	1.1	-1.1	-1.3	1.4	-1.6	1.7	1.7
Time in familiar zone, hab. session 1	5.7	5.5	6.1	2.2	-2.5	2.5	2.4	-2.4	2.3	-2.1	-2.3
Time in novel zone, hab. session 1	5.0	5.0	5.4	-1.9	2.3	-2.3	-2.3	2.3	-2.2	2.1	2.3
Total zone transitions, hab. session 1	0.1	0.1	0.5	0.7	-0.3	0.3	0.2	-0.1	-0.0	0.1	0.2
Total locomotion distance, hab. session 1	0.4	0.6	2.3	1.5	-0.9	0.9	0.7	-0.5	0.4	-0.3	-0.1
Locomotion velocity, hab. session 1	0.6	0.9	2.6	1.6	-1.1	1.1	0.9	-0.7	0.6	-0.5	-0.3
Time in familiar zone, hab. session 2	6.8	7.2	8.2	2.5	-2.6	2.6	2.7	-2.7	2.7	-2.9	-2.7
Time in novel zone, hab. session 2	8.3	8.4	10.1	-2.6	2.8	-2.8	-2.9	2.9	-3.0	3.2	3.0
Total zone transitions, hab. session 2	1.6	2.1	3.5	-0.7	1.3	-1.3	-1.4	1.5	-1.6	1.6	1.9
Total locomotion distance, hab. session 2	0.1	0.1	0.6	0.8	-0.3	0.3	0.2	-0.1	0.1	-0.1	0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.8	0.9	-0.3	0.3	0.2	-0.1	0.0	-0.0	0.2
Novel to familiar place preference ratio	4.1	4.5	4.9	-1.8	2.1	-2.1	-2.2	2.2	-2.2	2.2	2.2
Novelty place preference	3.0	3.2	3.6	-1.5	1.8	-1.8	-1.8	1.8	-1.8	1.9	1.9
Time in novel zone, NPP test	3.8	4.0	4.3	-1.8	2.0	-2.0	-2.0	2.1	-2.0	2.1	2.1
Total zone transitions, NPP test	0.5	0.7	0.9	-0.5	0.9	-0.9	-0.9	0.9	-0.8	0.8	0.9
Total locomotion distance, NPP test	0.2	0.2	0.4	0.0	0.5	-0.5	-0.5	0.6	-0.5	0.5	0.7
Locomotion velocity, NPP test	0.0	0.0	0.1	0.4	0.1	-0.1	-0.1	0.2	-0.1	0.1	0.3
Intraocular pressure	1.0	1.4	1.8	0.7	-1.1	1.1	1.2	-1.3	1.2	-1.3	-1.4
Delta distance traveled before/after self-admin	0.4	0.4	0.6	-0.8	0.7	-0.7	-0.6	0.6	-0.5	0.6	0.5
Delta ambulatory time before/after self-admin	0.6	0.7	0.8	-0.8	0.9	-0.9	-0.9	0.9	-0.9	0.9	0.8
Parametrial fat weight	0.5	1.2	1.4	-1.1	1.1	-1.1	-1.1	1.1	-1.0	1.2	1.0
Pavlov. Cond. lever latency	0.4	0.5	1.3	-0.2	-0.2	0.2	0.5	-0.6	1.0	-0.9	-1.1
Pavlov. Cond. magazine entry latency	1.2	1.6	2.1	1.5	-1.3	1.3	1.3	-1.2	1.1	-1.2	-1.0
Pavlov. Cond. change in total contacts	0.3	0.3	0.4	-0.5	0.6	-0.6	-0.6	0.6	-0.6	0.5	0.6
Pavlov. Cond. index score	0.1	0.2	0.7	0.8	-0.5	0.5	0.3	-0.3	0.1	-0.2	0.0
Pavlov. Cond. latency score	0.1	0.1	0.7	0.8	-0.4	0.4	0.2	-0.1	-0.1	0.1	0.3
Pavlov. Cond. lever contacts	0.5	0.5	1.3	0.1	0.4	-0.4	-0.6	0.7	-1.0	0.9	1.2
Pavlov. Cond. magazine entry number	0.5	0.7	0.9	-0.9	0.9	-0.9	-0.9	0.8	-0.7	0.8	0.7
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.7	0.2	-0.4	0.4	0.5	-0.6	0.8	-0.7	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.7	0.9	-0.6	0.6	0.4	-0.3	0.2	-0.3	-0.1
Pavlov. Cond. response bias	0.4	0.4	0.7	0.9	-0.8	0.8	0.7	-0.6	0.5	-0.5	-0.5
Pavlov. Cond. lever latency	2.0	2.8	3.4	-1.7	1.5	-1.5	-1.6	1.6	-1.8	1.7	1.8
Pavlov. Cond. magazine entry latency	2.5	3.1	3.5	1.8	-1.6	1.6	1.7	-1.7	1.9	-1.8	-1.8
Pavlov. Cond. change in total contacts	0.9	1.5	1.9	1.1	-1.1	1.1	1.2	-1.2	1.4	-1.4	-1.4
Pavlov. Cond. index score	2.4	3.2	3.8	1.7	-1.6	1.6	1.7	-1.7	1.9	-1.8	-1.9
Pavlov. Cond. latency score	2.4	3.2	3.6	1.8	-1.7	1.7	1.7	-1.7	1.9	-1.8	-1.8
Pavlov. Cond. lever contacts	2.1	2.9	3.5	1.6	-1.5	1.5	1.7	-1.7	1.9	-1.7	-1.9
Pavlov. Cond. magazine entry number	2.5	3.1	3.6	-1.8	1.6	-1.6	-1.7	1.7	-1.9	1.8	1.8
Pavlov. Cond. intertrial magazine entries	0.7	1.0	1.5	-1.2	1.0	-1.0	-1.0	0.9	-1.0	1.1	0.9
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.2	3.8	1.8	-1.6	1.6	1.7	-1.7	1.9	-1.8	-1.9
Pavlov. Cond. response bias	3.2	4.4	5.4	1.9	-1.9	1.9	2.1	-2.1	2.3	-2.2	-2.3
Time in closed arm before self-admin	0.3	0.4	0.6	-0.2	0.6	-0.6	-0.6	0.7	-0.7	0.8	0.8
Time in closed arm after self-admin	0.6	0.6	0.9	-0.8	0.9	-0.9	-0.8	0.7	-0.7	0.9	0.6
Time in open arm before self-admin	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1	0.1	-0.1	-0.1	0.1
Time in open arm after self-admin	0.9	0.9	1.6	-1.3	1.1	-1.1	-1.0	1.0	-0.9	0.6	0.8
Bone: periosteal estimation	2.1	4.5	5.9	-1.5	2.0	-2.0	-2.2	2.2	-2.2	2.4	2.3
Bone: periosteal perimeter	0.6	1.0	1.9	-0.1	0.7	-0.7	-0.9	1.0	-1.2	1.3	1.4
Bone: post-yield work	0.5	0.7	1.0	-1.0	0.9	-0.9	-0.8	0.8	-0.7	0.9	0.6
Progressive ratio test 1 active lever presses	0.4	0.4	0.7	-0.8	0.7	-0.7	-0.7	0.7	-0.6	0.5	0.6
Progressive ratio test 1 breakpoint	0.4	0.4	0.7	-0.8	0.7	-0.7	-0.7	0.6	-0.6	0.5	0.6
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.1	0.3	-0.3	0.3	0.3	-0.3	0.3	-0.3	-0.2
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	-0.0	0.0	-0.2	-0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	0.2	-0.2	0.2	0.2	-0.2	0.1	-0.3	-0.1
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.7	-0.4	0.6	-0.6	-0.7	0.7	-0.7	0.5	0.8
Incentive Sensitization - Responses	0.4	0.5	0.6	0.7	-0.8	0.8	0.7	-0.7	0.7	-0.8	-0.7
Incentive Sensitization - Breakpoint	0.5	0.6	0.7	0.8	-0.8	0.8	0.8	-0.7	0.7	-0.8	-0.7
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.3	-0.4	0.4	0.4	-0.4	0.3	-0.2	-0.3
Progressive ratio	0.6	1.0	1.7	-1.3	1.2	-1.2	-1.1	1.0	-0.8	0.6	0.7
Food seeking constrained by brief footshock	2.2	2.7	3.4	1.7	-1.8	1.8	1.7	-1.6	1.4	-1.4	-1.4
Seeking ratio, punishment vs. effort	2.4	3.4	4.5	2.1	-2.1	2.1	1.9	-1.9	1.6	-1.4	-1.5
Retroperitoneal fat weight	1.2	5.2	9.9	-3.2	2.6	-2.6	-2.2	2.0	-1.8	1.9	1.5
Reaction time number correct	0.2	0.3	1.2	-1.1	0.7	-0.7	-0.5	0.4	-0.3	0.3	0.1
Reaction time mean minus median	0.6	1.5	2.1	1.4	-1.3	1.3	1.3	-1.2	1.2	-1.0	-1.1
Reaction time mean minus median AUC	0.3	0.7	2.2	1.5	-0.9	0.9	0.8	-0.7	0.6	-0.4	-0.5
Reaction time num false alarms	0.3	0.5	0.8	-0.8	0.9	-0.9	-0.8	0.7	-0.5	0.3	0.5
Reaction time num false alarms AUC	0.2	0.4	0.6	-0.7	0.8	-0.8	-0.7	0.6	-0.4	0.2	0.4
Reaction time trials correct on left	0.2	0.3	1.2	-1.1	0.7	-0.7	-0.5	0.4	-0.3	0.3	0.1
Reaction time trials on left	0.2	0.3	1.1	-1.1	0.7	-0.7	-0.5	0.4	-0.3	0.4	0.1
Reaction time mean	0.4	0.7	1.7	1.3	-1.0	1.0	0.9	-0.7	0.5	-0.4	-0.4
Reaction time mean AUC	0.1	0.2	0.6	0.8	-0.5	0.5	0.4	-0.3	0.0	0.1	0.1
Median of all reaction times	0.2	0.3	0.8	0.9	-0.7	0.7	0.5	-0.4	0.2	-0.1	-0.1
Reaction time omissions	0.1	0.1	0.3	-0.0	0.3	-0.3	-0.3	0.3	-0.4	0.6	0.5
Reaction time false alarm rate	0.1	0.2	0.3	-0.2	0.5	-0.5	-0.5	0.5	-0.4	0.2	0.5
Reaction time premature initiation rate	2.3	3.1	3.8	1.6	-1.8	1.8	1.8	-1.8	1.8	-2.0	-1.8
Reaction time premature initiations	1.3	2.2	3.0	0.9	-1.4	1.4	1.5	-1.6	1.6	-1.7	-1.7
Std. dev. reaction times	0.3	0.5	1.1	1.1	-0.8	0.8	0.7	-0.6	0.5	-0.3	-0.4
Reaction time trials completed	0.2	0.3	1.1	-1.1	0.7	-0.7	-0.5	0.4	-0.3	0.4	0.1
Reaction time trials AUC	0.2	0.3	1.3	-1.1	0.7	-0.7	-0.5	0.4	-0.2	0.2	0.1
Run reversals in cocaine runway, females	1.6	1.5	3.0	1.7	-1.4	1.4	1.3	-1.2	0.9	-0.9	-0.8
Run reversals in cocaine runway, males	1.0	1.0	2.2	1.5	-1.3	1.3	1.0	-0.9	0.6	-0.4	-0.5
Latency to leave start box in cocaine runway	0.4	0.4	0.6	-0.1	0.8	-0.8	-0.6	0.7	-0.6	0.6	0.8
Latency to leave start box in cocaine runway, F	0.8	1.0	1.6	-0.2	0.9	-0.9	-0.9	1.0	-1.1	1.2	1.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.4	0.1	0.0	-0.0	0.3	-0.3	0.5	-0.7	-0.5
Std. dev. time between licks in bursts	0.2	0.3	0.6	0.8	-0.5	0.5	0.5	-0.5	0.6	-0.5	-0.5
Total sessions with >9 infusions	1.2	1.5	1.6	-1.1	1.2	-1.2	-1.2	1.2	-1.2	1.2	1.2
Short access day 1 total inactive lever presses	0.5	0.7	0.9	0.5	-0.9	0.9	0.8	-0.9	0.9	-0.9	-0.9
Short access day 10 total inactive lever presses	0.4	0.9	1.6	0.1	-0.8	0.8	0.9	-1.0	1.1	-1.1	-1.3
Short access day 1 total infusions	1.1	1.4	1.5	-1.1	1.2	-1.2	-1.2	1.2	-1.2	1.1	1.2
Short access day 10 total infusions	0.3	0.3	0.5	-0.7	0.6	-0.6	-0.6	0.6	-0.5	0.5	0.5
Short access total infusions	1.6	2.0	2.3	-1.3	1.5	-1.5	-1.5	1.5	-1.4	1.3	1.4
Short access day 1 locomotion	0.3	0.3	0.5	0.3	-0.6	0.6	0.6	-0.6	0.7	-0.6	-0.7
Short access day 10 total locomotion	1.8	3.2	3.8	1.3	-1.8	1.8	1.9	-1.9	1.8	-1.8	-1.9
Short access total locomotion	0.3	0.3	0.4	0.3	-0.6	0.6	0.6	-0.6	0.6	-0.6	-0.6
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.5	0.3	-0.3	-0.3	0.3	-0.4	0.3	0.4
Compulsive drug intake	0.0	0.0	0.0	0.2	-0.1	0.1	0.0	-0.0	-0.0	0.1	0.0
One hour access (shock baseline)	0.0	0.0	0.1	0.0	-0.2	0.2	0.2	-0.2	0.1	-0.3	-0.1
Social response proportion	1.0	1.1	1.6	1.3	-1.1	1.1	1.0	-1.0	1.1	-1.0	-0.9
Social responses	7.4	9.6	14.4	3.8	-3.4	3.4	3.1	-2.9	2.8	-2.7	-2.5
Social time	0.6	0.8	1.4	-1.2	1.0	-1.0	-0.9	0.9	-0.8	0.7	0.7
Soleus weight	5.6	16.5	18.4	-4.2	4.3	-4.3	-4.1	4.0	-4.0	3.7	3.9
Bone: stiffness	5.2	8.4	8.9	-2.8	2.9	-2.9	-3.0	3.0	-2.9	2.9	2.8
Tibialis anterior weight	1.4	4.6	5.0	-2.2	2.1	-2.1	-2.1	2.1	-2.2	2.2	2.1
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.2	1.1	-0.7	0.7	0.6	-0.5	0.4	-0.0	-0.3
Time to tail flick, vehicle, after self-admin	1.0	1.3	1.7	0.8	-1.1	1.1	1.2	-1.2	1.2	-1.3	-1.3
Time to tail flick, test, before self-admin	0.1	0.1	0.6	0.7	-0.3	0.3	0.2	-0.1	0.1	-0.1	0.0
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.1	0.3	-0.3	-0.3	0.4	-0.5	0.5	0.5
Delta time to tail flick, vehicle, before/after SA	0.2	0.1	0.7	-0.9	0.4	-0.4	-0.2	0.1	-0.1	-0.2	-0.1
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	-0.1	-0.3	0.3	0.4	-0.5	0.5	-0.4	-0.6
Tibia length	1.3	3.5	4.0	1.8	-1.8	1.8	1.8	-1.9	2.0	-1.9	-1.9
Ambulatory time before self-admin	0.3	0.4	0.5	0.7	-0.7	0.7	0.7	-0.7	0.6	-0.6	-0.5
Ambulatory time after self-admin	0.0	0.0	0.0	0.1	-0.0	0.0	0.0	0.0	-0.1	0.2	0.1
Bone: tissue strength	7.1	7.2	7.5	-2.6	2.7	-2.7	-2.7	2.7	-2.7	2.7	2.7
Total heroin consumption	1.7	2.0	3.1	1.7	-1.6	1.6	1.4	-1.4	1.2	-1.2	-1.1
Bone: trabecular number	0.1	0.2	0.6	0.8	-0.3	0.3	0.0	0.1	-0.4	0.5	0.6
Bone: trabecular spacing	0.4	0.6	1.3	-0.4	-0.3	0.3	0.6	-0.7	0.9	-1.1	-1.1
Bone: trabecular thickness	1.9	2.4	4.1	-0.3	1.3	-1.3	-1.6	1.7	-1.7	1.8	2.0
Bone: trabecular tissue density	4.0	5.9	8.3	-2.9	2.5	-2.5	-2.4	2.3	-2.3	2.3	2.1
Water consumed over 24 hours	0.9	1.2	1.4	-0.8	1.2	-1.2	-1.2	1.2	-1.1	1.1	1.2
Number of responses in last shaping day	2.2	2.4	2.5	1.4	-1.5	1.5	1.6	-1.6	1.6	-1.6	-1.6