Hub : Genes

LOC134479757

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC134479757	0.04	0.02	4.1e-04	0.03	0.02	0.02	0.02	1.5e-04	1.6e-03	3.7e-03	1.3e-03
2	IC	gene expression	LOC134479757	0.06	0.04	7.4e-03	0.02	0.02	0.01	0.01	4.1e-02	3.2e-02	9.2e-02	9.3e-02
3	NAcc	gene expression	LOC134479757	0.26	0.11	0.0e+00	0.15	0.1	0.17	0.16	5.7e-22	1.0e-14	6.3e-25	2.3e-23
4	Adipose	gene expression	LOC134479757	0.2	0.08	0.0e+00	0.14	0.15	0.14	0.15	3.5e-15	3.4e-16	2.2e-15	4.2e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.1	0.1	-0.4	-0.0	-0.2	0.3
Area under the delay curve	0.9	1.0	2.1	-0.9	-0.2	-1.0	1.4
BMI with tail	1.4	5.0	5.7	2.3	1.9	2.4	-2.3
BMI without tail	0.1	0.2	0.4	0.4	0.3	0.5	-0.6
Body weight	1.6	7.2	8.5	2.8	2.6	2.9	-2.4
Weight adjusted by age	0.1	0.1	0.2	-0.0	-0.5	-0.1	0.3
Bone surface	0.4	0.8	1.7	-1.0	-0.3	-0.7	1.3
Bone volume	0.0	0.1	0.1	-0.3	0.1	-0.2	0.4
Breakpoint value in progressive ratio session	0.1	0.2	0.3	0.4	0.6	0.3	-0.3
Number of licking bursts	1.1	1.7	2.7	-1.4	-1.1	-1.0	1.6
Context. condit. distance diff. score	5.5	6.6	8.5	2.9	1.7	2.6	-2.9
Locomotion velocity, session 1	0.8	0.9	2.1	-0.9	-0.2	-0.7	1.5
Locomotion distance, session 1	5.0	6.2	9.1	-2.7	-1.7	-2.5	3.0
Locomotion velocity, session 2	0.2	0.2	0.4	0.4	0.6	0.5	-0.3
Locomotion distance, session 2	3.3	4.6	8.0	-2.3	-1.0	-2.0	2.8
Locomotion velocity, session 3	0.1	0.1	0.3	0.0	-0.6	0.1	-0.1
Locomotion distance, session 3	3.0	3.2	4.2	-1.7	-2.0	-1.6	1.7
Stereotopy head waving bouts, day 3	1.1	1.3	2.1	1.1	1.5	1.1	-0.7
Stereotopy head waving duration, day 3	4.5	5.4	6.1	2.4	2.5	2.3	-2.1
Locomotion velocity, session 7	0.1	0.1	0.2	0.3	0.1	0.4	-0.2
Locomotion distance, session 7	0.1	0.1	0.4	-0.3	0.1	-0.3	0.6
Stereotopy head waving bouts, day 7	1.5	1.7	2.1	1.4	0.7	1.4	-1.5
Stereotopy head waving duration, day 7	2.4	2.9	5.1	1.8	0.9	1.6	-2.3
Locomotion velocity, session 8	1.2	1.5	2.1	1.2	1.4	1.4	-0.6
Locomotion distance, session 8	0.5	0.7	1.1	0.9	0.4	0.8	-1.0
Degree of sensitization distance	4.8	5.0	6.1	2.2	2.5	2.0	-2.2
Degree of sensitization stereotypy	1.1	1.1	1.6	1.2	0.5	1.2	-1.3
Conditioned locomotion	0.4	0.4	0.6	0.7	0.5	0.5	-0.8
Cocaine response after cond. corrected	0.2	0.2	0.3	0.5	0.6	0.3	-0.3
Cocaine response after cond. not corrected	0.1	0.2	0.3	0.4	0.4	0.2	-0.5
Cocaine response before conditioning	0.2	0.2	0.5	-0.4	-0.7	-0.5	-0.1
Saline control response	0.1	0.2	0.4	0.0	-0.6	-0.5	-0.4
Bone: connectivity density	0.0	0.0	0.1	-0.1	0.2	0.1	0.2
Bone: cortical apparent density	1.4	2.0	3.2	-1.4	-1.8	-1.0	1.2
Bone: cortical area	1.6	2.5	4.0	1.5	2.0	1.6	-1.1
Bone: cortical porosity	1.2	1.3	2.2	1.1	1.0	0.8	-1.5
Bone: cortical porosity	2.7	2.9	3.4	1.7	1.8	1.5	-1.9
Bone: cortical thickness	0.4	0.6	1.1	0.6	1.0	1.0	-0.2
Bone: cortical thickness	0.4	0.4	1.1	0.2	1.0	0.7	0.4
Bone: cortical tissue density	1.4	1.9	3.1	-1.4	-1.8	-1.0	1.2
Condit. Reinf. active minus inactive responses	0.3	0.4	0.8	-0.7	-0.4	-0.3	0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.2	-0.0	0.4	-0.2
Condit. Reinf. active responses	1.4	1.7	2.2	-1.5	-1.3	-1.3	1.2
Condit. Reinf. inactive responses	2.4	3.0	4.2	-1.8	-1.7	-2.0	1.2
Incentive salience index mean	0.6	0.7	1.2	-1.0	-0.6	-0.6	1.1
Condit. Reinf. lever presses	0.7	1.0	1.2	-1.1	-0.8	-1.0	1.0
Condit. Reinf. active minus inactive responses	0.5	0.6	1.8	-0.7	0.3	-0.1	1.4
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.7	-0.0	0.8	0.6	0.7
Condit. Reinf. active responses	0.2	0.3	0.6	-0.1	0.6	0.4	0.8
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.2	0.5	0.3	0.2
Condit. Reinf. lever presses	0.3	0.4	0.6	-0.7	-0.3	-0.5	0.8
Condit. Reinf. lever reinforcers received	0.2	0.2	0.5	-0.2	0.5	0.2	0.7
Conditioned reinforcement - actives	0.2	0.3	0.5	0.4	0.6	0.7	0.2
Conditioned reinforcement - inactives	0.3	0.4	0.8	-0.5	0.5	-0.4	0.9
Conditioned locomotion	1.9	2.4	3.7	1.5	1.9	1.7	-0.9
Patch foraging indifference point 0 sec	0.1	0.1	0.2	-0.4	-0.2	-0.5	0.4
Patch foraging indifference point AUC	1.5	2.2	4.7	-1.4	-0.8	-1.3	2.2
Delay disc. indifference point, 0s delay	1.5	1.7	2.2	1.2	1.5	0.9	-1.5
Delay disc. indifference point, 16s delay	2.0	2.2	3.4	-1.6	-0.8	-1.5	1.9
Delay disc. indifference point, 2s delay	0.2	0.2	0.5	-0.2	0.3	-0.3	0.7
Delay disc. indifference point, 24s delay	1.3	1.5	4.3	-0.9	-0.2	-0.8	2.1
Delay disc. indifference point, 4s delay	0.4	0.4	1.0	-0.6	0.1	-0.5	1.0
Delay disc. indifference point, 8s delay	1.3	1.5	2.5	-1.2	-0.7	-1.3	1.6
Indifference point function ln k	1.4	2.4	3.9	1.7	0.7	1.6	-2.0
Indifference point function log k	1.4	2.4	3.9	1.7	0.7	1.6	-2.0
Patch foraging total patch changes 0 sec	0.1	0.3	0.4	-0.6	-0.4	-0.7	0.5
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	-0.2	0.1	-0.3	0.6
Patch foraging total patch changes 18 sec	0.2	0.4	0.8	-0.4	0.4	-0.6	0.9
Patch foraging total patch changes 24 sec	0.4	0.8	1.2	-0.8	-0.4	-1.1	1.0
Patch foraging total patch changes 6 sec	0.6	0.9	2.2	-0.8	0.2	-0.8	1.5
Patch foraging time to switch 0 sec	0.3	0.5	1.5	0.5	0.6	0.1	-1.2
Patch foraging water rate 0 sec	0.1	0.1	0.4	-0.3	-0.1	-0.2	0.7
Patch foraging water rate 12 sec	0.3	0.7	1.0	-1.0	-1.0	-0.7	0.5
Patch foraging water rate 18 sec	0.8	1.2	1.6	-1.2	-0.8	-1.1	1.3
Patch foraging water rate 24 sec	0.2	0.2	0.3	0.5	0.3	0.5	-0.5
Patch foraging water rate 6 sec	1.5	2.2	3.6	-1.5	-1.9	-1.2	1.2
Seeking ratio, delayed vs. immediate footshock	1.5	1.8	2.1	-1.5	-1.3	-1.3	1.3
Distance traveled before self-admin	0.0	0.0	0.1	-0.0	0.1	-0.4	-0.0
Distance traveled after self-admin	0.2	0.3	0.6	-0.3	0.6	-0.2	0.8
Extensor digitorum longus weight	0.1	0.2	0.4	-0.4	-0.7	-0.6	-0.2
Bone: elastic displacement	0.0	0.0	0.1	0.0	0.0	0.3	0.0
Bone: elastic work	3.2	4.1	5.5	2.0	2.3	1.9	-1.8
Bone: endosteal estimation	0.5	1.2	2.2	1.1	1.5	0.5	-1.0
Bone: endosteal perimeter	1.3	2.7	3.3	1.7	1.8	1.4	-1.7
Epididymis fat weight	3.1	10.5	12.1	3.5	2.9	3.1	-3.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.2	0.5	0.4	0.2
Delta time in open arm before/after self-admin	0.4	0.4	0.8	-0.6	-0.5	-0.9	0.4
Diff in mean of infusions in LGA sessions	0.2	0.3	0.5	0.4	0.7	0.6	0.4
Delay discount exponential model param	1.1	1.2	2.5	1.0	0.3	1.1	-1.6
Extinction: sum of active levers before priming	1.1	1.3	2.6	1.1	1.6	1.0	-0.6
Active lever presses in extinction session 6	0.5	0.5	0.6	0.8	0.8	0.6	-0.7
Bone: final force	1.9	3.1	5.7	1.6	2.4	1.7	-1.0
Bone: final moment	2.0	3.2	6.2	1.7	2.5	1.8	-0.9
Food consumed during 24 hour testing period	1.9	2.6	4.0	1.5	2.0	1.8	-1.0
Glucose	0.2	0.2	0.6	0.5	0.3	0.3	-0.8
Heart weight	6.4	9.9	11.5	3.2	3.4	3.1	-2.8
Delay discount hyperbolic model param	0.9	1.1	2.2	0.9	0.3	1.0	-1.5
Intermittent access intake day 1-15 change	0.1	0.2	0.5	-0.5	-0.7	-0.3	-0.0
Intermittent access intake escalation	0.3	0.5	1.0	-0.8	-1.0	-0.6	0.3
Intermittent access intake escalation 2	0.3	0.3	0.6	-0.6	-0.8	-0.5	-0.1
Intermitt. access day 1 inactive lever presses	0.3	1.2	1.7	0.9	1.3	1.1	-0.9
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	-0.1	0.3	0.1	0.3
Intermitt. access escalation Index	0.3	0.4	0.6	-0.5	-0.7	-0.7	0.6
Intermittent access day 1 total infusions	0.4	0.6	1.8	0.6	1.3	0.4	-0.0
Intermittent access day 15 total infusions	0.2	0.4	0.5	-0.7	-0.3	-0.7	0.7
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.1	-0.2	-0.1	-0.4	0.1
Intermittent access total infusions	0.2	0.3	0.9	0.3	1.0	0.0	0.0
Intermittent access day 1 locomotion	0.3	0.4	1.2	0.6	1.1	0.3	-0.3
Intermittent access day 15 total locomotion	0.3	0.6	1.4	0.7	1.2	0.5	-0.5
Intermittent access total locomotion	0.7	0.9	2.2	0.8	1.5	0.6	-0.5
Intermittent access standard deviation	1.0	2.2	3.3	1.4	1.6	1.1	-1.8
Left kidney weight	9.0	41.7	48.7	6.8	6.5	7.0	-5.4
Right kidney weight	11.8	53.6	61.3	7.7	7.4	7.8	-6.3
Cocaine induced anxiety	2.2	3.1	3.9	2.0	1.9	1.7	-1.4
Post-drug Anxiety	0.1	0.1	0.2	0.4	0.2	0.4	-0.2
Baseline Anxiety	4.5	5.2	6.1	-2.5	-2.4	-2.2	2.1
Tail length	0.4	1.8	2.1	-1.4	-1.4	-1.5	0.9
Length with tail	0.1	0.6	0.8	0.8	0.7	0.9	-0.6
Length without tail	2.4	7.9	8.9	2.9	3.0	3.0	-2.3
Times rat made contact with spout	0.2	0.3	0.5	0.1	0.6	0.7	0.4
Lifetime Intake	0.7	0.9	2.6	0.8	1.6	0.6	-0.1
Liver weight, left	0.3	0.5	0.8	0.8	0.1	0.6	-0.9
Liver weight, right	2.0	3.4	6.4	2.0	0.4	1.7	-2.5
Locomotor activity	1.8	2.8	3.1	1.7	1.6	1.8	-1.7
Locomotor testing distance	0.0	0.1	0.2	-0.4	-0.3	-0.2	0.2
Locomotor testing rearing	0.9	1.7	2.0	1.4	1.2	1.3	-1.4
Locomotion in novel chamber	1.6	2.1	4.3	-1.5	-2.1	-1.1	0.7
Locomotion in novel chamber post-restriction	0.5	0.9	1.3	-0.9	-1.2	-1.1	0.5
Fecal boli incidents, locomotor time 1	0.2	0.3	0.7	-0.3	0.3	-0.6	0.8
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	0.0	-0.2	0.7	0.6
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.3	1.1	1.0	0.7	-0.7
Bouts of movement, locomotor time 1	0.6	0.7	0.9	0.8	1.0	0.9	-0.7
Total resting periods, locomotor time 1	0.5	0.6	1.0	0.7	1.0	0.8	-0.5
Rest time, locomotor task time 1	0.9	1.1	1.6	0.9	1.3	1.2	-0.6
Distance moved, locomotor task time 1	0.2	0.3	0.8	0.5	-0.1	0.2	-0.9
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.2	-0.1	-0.2	-0.3
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.0	0.1	0.0	0.2
Bouts of movement, locomotor time 2	0.3	0.4	0.6	0.7	0.5	0.8	-0.6
Total resting periods, locomotor time 2	0.2	0.3	0.4	0.6	0.6	0.6	-0.3
Rest time, locomotor task time 2	0.2	0.2	0.7	-0.4	-0.1	-0.2	0.8
Distance moved, locomotor task time 2	0.4	0.5	1.3	0.6	0.2	0.7	-1.1
Vertical activity count, locomotor time 2	0.2	0.3	0.4	0.6	0.5	0.3	-0.6
Light reinforcement 1	0.0	0.1	0.2	-0.4	-0.1	-0.2	0.3
Light reinforcement 2	0.7	1.1	2.0	1.0	0.4	1.2	-1.4
Bone: marrow area	0.6	1.3	2.5	1.1	1.6	0.6	-1.1
Bone: maximum diameter	3.7	6.9	10.0	2.6	3.2	2.6	-2.0
Bone: maximum force	2.6	4.6	8.8	2.0	3.0	2.1	-1.1
Bone: maximum moment	2.9	5.0	9.6	2.1	3.1	2.2	-1.2
Mean time between licks in bursts	0.1	0.3	0.7	-0.5	-0.8	-0.6	0.2
Mean num. licks in bursts	1.4	2.1	2.4	1.5	1.4	1.5	-1.3
Cd content in liver	0.3	0.3	0.7	0.4	0.5	0.8	0.4
Co content in liver	0.2	0.2	0.6	-0.3	0.4	0.3	0.8
Cu content in liver	5.3	6.3	8.1	-2.8	-2.2	-2.6	2.4
Fe content in liver	1.5	1.9	2.8	1.4	1.7	1.0	-1.3
K content in liver	1.5	1.4	1.9	-1.4	-1.2	-1.0	1.1
Mg content in liver	0.8	0.9	1.3	-1.1	-0.7	-0.8	1.0
Mn content in liver	0.2	0.2	0.5	-0.4	-0.7	-0.3	0.4
Na content in liver	1.3	1.4	2.1	-1.3	-1.1	-1.5	0.9
Rb content in liver	0.2	0.3	0.5	-0.1	0.7	0.3	0.7
Se content in liver	0.5	0.6	1.3	-0.7	-1.2	-0.6	0.4
Sr content in liver	2.2	1.9	3.0	-1.3	-1.7	-1.4	1.0
Zn content in liver	0.2	0.2	0.4	-0.5	-0.4	-0.3	0.6
Bone: minimum diameter	0.4	0.8	1.6	0.8	1.3	0.6	-0.8
Time in familiar zone, hab. session 1	0.3	0.3	0.9	-0.3	0.3	-0.1	0.9
Time in novel zone, hab. session 1	1.5	1.5	3.6	1.2	0.5	0.9	-1.9
Total zone transitions, hab. session 1	7.1	9.9	11.1	-3.3	-3.1	-2.9	3.2
Total locomotion distance, hab. session 1	4.2	6.0	7.0	-2.5	-2.6	-2.4	2.2
Locomotion velocity, hab. session 1	4.5	6.4	6.9	-2.6	-2.5	-2.5	2.4
Time in familiar zone, hab. session 2	0.2	0.2	0.5	-0.1	-0.7	-0.4	-0.4
Time in novel zone, hab. session 2	0.2	0.2	0.5	0.1	0.7	0.3	0.3
Total zone transitions, hab. session 2	2.8	3.6	6.6	-2.1	-1.0	-1.6	2.6
Total locomotion distance, hab. session 2	1.5	1.9	2.9	-1.6	-0.8	-1.3	1.7
Locomotion velocity, hab. session 2	2.4	3.2	4.5	-2.0	-1.1	-1.8	2.1
Novel to familiar place preference ratio	2.2	2.4	3.0	1.7	1.2	1.7	-1.6
Novelty place preference	2.9	3.1	3.8	2.0	1.3	1.9	-1.8
Time in novel zone, NPP test	3.5	3.8	4.6	2.1	1.5	2.1	-1.9
Total zone transitions, NPP test	6.4	9.2	11.5	-3.2	-2.7	-2.8	3.4
Total locomotion distance, NPP test	2.9	4.0	5.2	-2.1	-1.7	-1.8	2.3
Locomotion velocity, NPP test	3.7	5.2	5.9	-2.4	-2.0	-2.2	2.4
Intraocular pressure	0.1	0.1	0.2	0.4	0.3	0.3	-0.1
Delta distance traveled before/after self-admin	0.3	0.3	0.6	0.1	0.8	0.5	0.6
Delta ambulatory time before/after self-admin	0.3	0.4	0.8	0.2	0.9	0.5	0.7
Parametrial fat weight	0.1	0.2	0.4	0.2	-0.5	-0.1	-0.6
Pavlov. Cond. lever latency	0.4	0.4	0.6	0.7	0.6	0.8	-0.6
Pavlov. Cond. magazine entry latency	0.5	0.6	1.1	-0.8	-0.4	-0.7	1.0
Pavlov. Cond. change in total contacts	1.4	1.5	3.0	-1.3	-0.5	-1.0	1.7
Pavlov. Cond. index score	0.2	0.3	0.6	-0.5	-0.2	-0.5	0.8
Pavlov. Cond. latency score	0.2	0.2	0.4	-0.4	-0.2	-0.4	0.6
Pavlov. Cond. lever contacts	1.1	1.4	1.9	-1.2	-1.0	-1.4	1.1
Pavlov. Cond. magazine entry number	0.7	0.9	1.6	1.0	0.6	0.8	-1.3
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.6	-1.1	-0.5	-1.0	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.9	-0.7	-0.4	-0.7	1.0
Pavlov. Cond. response bias	0.7	0.9	1.4	-1.0	-0.6	-1.0	1.2
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.7	0.4	0.5	-0.4
Pavlov. Cond. magazine entry latency	1.5	1.8	2.7	-1.6	-0.7	-1.3	1.6
Pavlov. Cond. change in total contacts	0.2	0.2	0.6	-0.2	0.8	0.1	0.6
Pavlov. Cond. index score	0.7	1.0	1.5	-1.2	-0.6	-1.0	1.1
Pavlov. Cond. latency score	1.2	1.6	2.2	-1.5	-0.8	-1.2	1.4
Pavlov. Cond. lever contacts	0.4	0.5	0.8	-0.9	-0.6	-0.7	0.6
Pavlov. Cond. magazine entry number	0.9	1.1	1.7	1.2	0.6	0.9	-1.3
Pavlov. Cond. intertrial magazine entries	1.4	2.0	2.8	1.5	1.5	1.7	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	1.4	-1.2	-0.6	-1.0	1.0
Pavlov. Cond. response bias	0.3	0.5	0.7	-0.9	-0.3	-0.7	0.8
Time in closed arm before self-admin	1.9	2.5	5.5	-1.5	-1.1	-2.4	0.9
Time in closed arm after self-admin	0.1	0.1	0.2	0.2	0.5	-0.2	-0.3
Time in open arm before self-admin	0.1	0.1	0.3	-0.1	-0.6	0.2	-0.0
Time in open arm after self-admin	0.4	0.5	0.9	-0.7	-1.0	-0.6	0.4
Bone: periosteal estimation	1.3	2.8	4.7	1.7	2.2	1.3	-1.4
Bone: periosteal perimeter	3.4	5.8	7.0	2.4	2.6	2.3	-2.3
Bone: post-yield work	0.4	0.5	1.4	0.2	1.2	0.5	0.6
Progressive ratio test 1 active lever presses	0.3	0.3	1.2	0.4	1.1	0.1	0.2
Progressive ratio test 1 breakpoint	0.2	0.2	0.8	0.3	0.9	-0.0	0.3
Progressive ratio test 1 inactive lever presses	0.4	0.6	1.7	0.5	1.3	0.5	-0.4
Progressive ratio test 2 active lever presses	0.2	0.3	0.6	-0.0	0.7	-0.1	0.8
Progressive ratio test 2 breakpoint	0.2	0.3	0.7	-0.1	0.6	-0.2	0.8
Progressive ratio test 2 inactive lever presses	0.4	0.7	1.2	-0.9	-0.3	-1.1	0.8
Incentive Sensitization - Responses	0.3	0.5	0.9	-0.7	-0.5	-0.5	0.9
Incentive Sensitization - Breakpoint	0.2	0.3	0.7	-0.5	-0.3	-0.3	0.8
Sum of active levers in priming session hrs 5-6	0.2	0.1	0.3	0.4	0.3	0.2	-0.5
Progressive ratio	0.0	0.0	0.1	0.1	0.2	-0.2	-0.3
Food seeking constrained by brief footshock	0.7	0.9	1.6	0.8	1.2	1.1	-0.5
Seeking ratio, punishment vs. effort	0.3	0.4	0.7	0.4	0.8	0.8	-0.0
Retroperitoneal fat weight	4.7	19.9	22.7	4.8	4.0	4.7	-4.3
Reaction time number correct	1.1	2.1	3.3	-1.5	-1.8	-1.4	1.1
Reaction time mean minus median	0.1	0.3	0.8	0.6	0.2	0.0	-0.9
Reaction time mean minus median AUC	0.6	1.4	2.9	1.3	0.7	0.8	-1.7
Reaction time num false alarms	0.1	0.1	0.2	-0.2	-0.4	-0.4	-0.3
Reaction time num false alarms AUC	0.2	0.4	0.6	-0.6	-0.8	-0.7	0.1
Reaction time trials correct on left	1.1	2.1	3.3	-1.5	-1.8	-1.4	1.1
Reaction time trials on left	1.3	2.4	3.6	-1.5	-1.9	-1.5	1.2
Reaction time mean	0.1	0.1	0.3	0.0	-0.2	-0.3	-0.6
Reaction time mean AUC	0.0	0.1	0.2	-0.0	-0.2	-0.3	-0.4
Median of all reaction times	0.1	0.1	0.1	-0.2	-0.4	-0.4	-0.3
Reaction time omissions	0.4	0.6	0.9	-0.8	-0.9	-1.0	0.5
Reaction time false alarm rate	0.1	0.2	0.5	0.3	0.2	0.1	-0.7
Reaction time premature initiation rate	0.1	0.2	0.4	0.0	0.7	0.1	0.4
Reaction time premature initiations	0.1	0.2	0.5	-0.5	-0.0	-0.3	0.7
Std. dev. reaction times	0.2	0.5	1.2	0.7	0.3	0.3	-1.1
Reaction time trials completed	1.3	2.4	3.6	-1.5	-1.9	-1.5	1.2
Reaction time trials AUC	0.9	1.6	2.5	-1.3	-1.6	-1.2	1.0
Run reversals in cocaine runway, females	0.6	0.6	0.8	-0.8	-0.9	-0.8	0.6
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.4	0.4	0.1	0.2
Latency to leave start box in cocaine runway	0.6	0.6	1.2	0.8	0.4	0.8	-1.1
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	-0.0	-0.2	0.0	-0.1
Latency to leave start box in cocaine runway, M	1.5	1.4	2.3	1.1	0.7	1.3	-1.5
Std. dev. time between licks in bursts	0.9	1.2	1.9	-1.2	-0.6	-1.1	1.4
Total sessions with >9 infusions	4.2	5.1	8.3	2.2	2.9	2.4	-1.2
Short access day 1 total inactive lever presses	1.0	1.4	4.5	0.6	2.1	0.8	0.1
Short access day 10 total inactive lever presses	0.2	0.6	0.7	0.6	0.8	0.8	-0.8
Short access day 1 total infusions	1.1	1.4	2.9	1.1	1.7	1.1	-0.6
Short access day 10 total infusions	1.8	2.3	4.1	1.5	2.0	1.3	-1.1
Short access total infusions	2.5	3.1	6.7	1.7	2.6	1.6	-0.7
Short access day 1 locomotion	0.8	1.0	1.3	1.0	1.2	1.0	-1.0
Short access day 10 total locomotion	0.2	0.3	0.7	0.4	0.5	0.2	-0.8
Short access total locomotion	1.9	2.2	2.9	1.4	1.7	1.4	-1.4
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.2	0.1	-0.5	0.0
Compulsive drug intake	1.4	1.7	4.5	-1.1	-0.9	-0.5	2.1
One hour access (shock baseline)	0.3	0.4	1.2	0.4	0.5	-0.1	-1.1
Social response proportion	1.1	1.3	2.2	1.1	0.9	1.0	-1.5
Social responses	0.2	0.2	0.4	-0.5	-0.3	-0.4	0.6
Social time	1.8	2.4	3.1	-1.8	-1.3	-1.7	1.5
Soleus weight	0.3	1.0	2.7	-1.0	-0.4	-0.5	1.6
Bone: stiffness	2.0	3.2	5.8	1.7	2.4	1.6	-1.2
Tibialis anterior weight	0.4	1.5	1.9	-1.3	-1.0	-1.4	1.2
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.1	0.3	-0.0	0.0
Time to tail flick, vehicle, after self-admin	1.0	1.4	2.2	-1.2	-1.0	-1.5	0.9
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.5	0.2	0.5	-0.5
Time to tail flick, test, after self-admin	0.4	0.4	0.6	-0.6	-0.7	-0.8	0.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.0	0.2	-0.1	-0.1
Delta time to tail flick, test, before/after SA	2.3	2.4	2.8	-1.6	-1.6	-1.7	1.3
Tibia length	0.5	1.4	2.5	1.2	1.6	1.4	-0.2
Ambulatory time before self-admin	0.2	0.4	0.6	-0.6	-0.5	-0.8	0.4
Ambulatory time after self-admin	1.5	1.7	3.1	-1.4	-0.6	-1.2	1.8
Bone: tissue strength	0.1	0.1	0.3	0.4	0.3	0.5	-0.2
Total heroin consumption	0.2	0.3	0.7	0.4	0.8	0.4	0.3
Bone: trabecular number	0.0	0.0	0.1	-0.1	-0.3	0.0	-0.1
Bone: trabecular spacing	1.2	1.6	3.5	1.1	1.9	1.2	-0.4
Bone: trabecular thickness	0.1	0.2	0.3	-0.0	-0.5	-0.3	-0.6
Bone: trabecular tissue density	0.7	1.1	1.5	-1.1	-1.0	-1.2	0.6
Water consumed over 24 hours	0.2	0.3	0.6	0.2	0.8	0.6	0.2
Number of responses in last shaping day	0.2	0.2	0.5	-0.2	0.7	-0.5	0.1