Hub : Genes

LOC134479637

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC134479637	0.12	0.07	0.0e+00	0.15	0.16	0.16	0.16	1.5e-21	2.7e-23	2.4e-23	4.5e-23
2	BLA	gene expression	LOC134479637	0.04	0.04	2.3e-03	0.04	0.05	0.04	0.04	3.6e-03	1.7e-03	4.9e-03	4.3e-03
3	NAcc	intron excision ratio	chr7_601346_602156	0.01	0.01	6.0e-03	0.01	0.01	0.01	0.01	3.7e-03	5.4e-03	1.5e-02	5.5e-03
4	NAcc	isoform ratio	XR_010053179.1	0.03	0.02	1.1e-06	0.04	0.03	0.03	0.03	2.0e-06	7.6e-06	7.1e-05	8.0e-06
5	NAcc	isoform ratio	XR_010053180.1	0.03	0.02	1.2e-06	0.04	0.03	0.03	0.03	2.1e-06	6.4e-06	7.6e-05	7.2e-06
6	NAcc	intron excision ratio	chr7_600260_601040	0.02	0.02	1.2e-03	0.01	0.02	0.01	0.02	1.4e-02	5.4e-04	5.0e-03	1.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.5	0.9	3.1	0.4	0.9	-0.6	-0.7	0.7	1.8
Area under the delay curve	0.0	0.0	0.1	0.2	0.1	0.1	-0.1	0.1	0.1
BMI with tail	6.9	23.8	27.8	-5.2	-4.9	5.3	5.0	-5.0	-3.7
BMI without tail	1.6	4.8	6.3	-2.3	-2.2	2.5	2.2	-2.2	-1.8
Body weight	0.9	4.1	4.8	-2.0	-2.1	2.2	2.0	-2.0	-1.9
Weight adjusted by age	0.0	0.0	0.1	0.1	0.0	-0.4	-0.2	0.2	-0.1
Bone surface	1.3	2.4	7.4	1.0	1.6	-1.1	-1.1	1.1	2.7
Bone volume	1.2	2.2	7.2	0.9	1.5	-1.0	-1.0	1.0	2.7
Breakpoint value in progressive ratio session	0.7	0.9	1.2	0.9	0.9	-0.8	-1.1	1.1	0.7
Number of licking bursts	3.1	5.1	5.5	-2.3	-2.3	2.1	2.2	-2.2	-2.3
Context. condit. distance diff. score	0.4	0.4	0.5	-0.7	-0.7	0.5	0.7	-0.7	-0.7
Locomotion velocity, session 1	0.2	0.3	0.9	0.3	0.5	-0.3	-0.3	0.3	1.0
Locomotion distance, session 1	0.7	0.9	2.4	0.8	1.0	-0.9	-0.7	0.7	1.6
Locomotion velocity, session 2	2.9	3.4	5.3	1.7	1.9	-1.8	-1.6	1.6	2.3
Locomotion distance, session 2	5.2	7.2	9.0	2.6	2.8	-2.7	-2.5	2.5	3.0
Locomotion velocity, session 3	3.3	3.8	4.4	2.1	2.0	-2.1	-2.0	2.0	1.4
Locomotion distance, session 3	0.1	0.1	0.1	0.4	0.3	-0.3	-0.4	0.4	0.2
Stereotopy head waving bouts, day 3	4.3	5.1	5.7	2.4	2.4	-2.4	-2.2	2.2	2.0
Stereotopy head waving duration, day 3	2.1	2.6	3.2	1.7	1.7	-1.8	-1.4	1.4	1.5
Locomotion velocity, session 7	0.0	0.0	0.1	0.1	0.2	-0.3	-0.0	0.0	0.3
Locomotion distance, session 7	0.5	0.6	1.1	-0.6	-0.8	0.6	0.7	-0.7	-1.0
Stereotopy head waving bouts, day 7	1.1	1.3	2.0	1.0	1.2	-1.2	-0.9	0.9	1.4
Stereotopy head waving duration, day 7	1.7	2.1	3.1	1.3	1.5	-1.5	-1.3	1.3	1.8
Locomotion velocity, session 8	2.7	3.2	4.6	1.7	1.9	-1.9	-1.6	1.6	2.1
Locomotion distance, session 8	0.7	1.0	1.4	1.0	1.0	-1.2	-0.9	0.9	1.0
Degree of sensitization distance	0.8	0.8	0.9	-0.9	-0.9	0.9	0.9	-0.9	-0.8
Degree of sensitization stereotypy	0.1	0.1	0.2	-0.2	0.1	-0.1	0.2	-0.2	0.5
Conditioned locomotion	1.5	1.8	2.7	-1.3	-1.4	1.0	1.3	-1.3	-1.6
Cocaine response after cond. corrected	4.6	5.5	5.9	-2.4	-2.4	2.0	2.4	-2.4	-2.4
Cocaine response after cond. not corrected	4.1	4.9	5.3	-2.3	-2.3	1.9	2.2	-2.2	-2.3
Cocaine response before conditioning	1.2	1.4	1.7	1.1	1.2	-1.0	-1.3	1.3	1.1
Saline control response	0.3	0.3	0.4	-0.5	-0.6	0.5	0.6	-0.6	-0.6
Bone: connectivity density	0.3	0.4	1.6	0.2	0.6	-0.5	-0.4	0.4	1.3
Bone: cortical apparent density	0.8	1.1	1.3	-1.2	-1.0	1.0	1.2	-1.2	-0.7
Bone: cortical area	0.2	0.3	0.5	-0.7	-0.4	0.5	0.7	-0.7	0.4
Bone: cortical porosity	0.1	0.2	0.4	0.1	0.4	-0.4	-0.3	0.3	0.6
Bone: cortical porosity	0.1	0.1	0.5	-0.1	0.3	-0.3	-0.1	0.1	0.7
Bone: cortical thickness	0.4	0.6	1.1	-1.0	-0.7	0.8	0.9	-0.9	-0.0
Bone: cortical thickness	0.4	0.5	0.6	-0.7	-0.8	0.6	0.6	-0.6	-0.8
Bone: cortical tissue density	0.5	0.7	0.9	-0.9	-0.8	0.8	1.0	-1.0	-0.5
Condit. Reinf. active minus inactive responses	1.3	1.5	1.7	1.2	1.2	-1.3	-1.3	1.3	1.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.3	-0.3	0.2	0.3	-0.3	-0.3
Condit. Reinf. active responses	3.7	4.5	4.9	2.1	2.1	-2.2	-2.2	2.2	2.0
Condit. Reinf. inactive responses	4.0	4.9	5.1	2.2	2.2	-2.2	-2.3	2.3	2.1
Incentive salience index mean	1.7	2.0	2.3	1.3	1.4	-1.5	-1.4	1.4	1.5
Condit. Reinf. lever presses	1.4	2.0	3.5	1.2	1.4	-1.4	-1.2	1.2	1.9
Condit. Reinf. active minus inactive responses	0.7	0.9	1.3	1.1	0.9	-1.1	-1.0	1.0	0.2
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.8	0.1	-0.2	0.0	0.1	-0.1	-0.9
Condit. Reinf. active responses	1.0	1.3	1.6	1.3	1.1	-1.3	-1.3	1.3	0.6
Condit. Reinf. inactive responses	0.7	0.9	1.1	0.9	0.9	-1.0	-1.1	1.1	0.9
Condit. Reinf. lever presses	1.4	1.9	2.7	1.6	1.4	-1.5	-1.5	1.5	0.6
Condit. Reinf. lever reinforcers received	0.6	0.9	1.2	1.0	0.8	-1.1	-1.1	1.1	0.3
Conditioned reinforcement - actives	0.0	0.0	0.2	-0.4	-0.2	-0.0	0.0	-0.0	-0.1
Conditioned reinforcement - inactives	0.6	0.9	1.1	-1.0	-1.0	0.7	1.0	-1.0	-1.1
Conditioned locomotion	1.9	2.4	2.7	1.4	1.6	-1.6	-1.6	1.6	1.4
Patch foraging indifference point 0 sec	2.4	4.4	5.4	-2.3	-2.0	2.2	2.3	-2.3	-1.2
Patch foraging indifference point AUC	0.1	0.2	0.2	0.4	0.4	-0.4	-0.5	0.5	0.1
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	-0.5	-0.3	0.6	0.4	-0.4	0.5
Delay disc. indifference point, 16s delay	0.3	0.3	0.6	0.7	0.6	-0.4	-0.6	0.6	0.5
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.0	0.0	0.5	-0.0	0.0	0.4
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.4	-0.3	0.4	0.4	-0.4	-0.2
Delay disc. indifference point, 4s delay	0.8	0.9	1.3	1.0	1.0	-0.8	-0.9	0.9	1.1
Delay disc. indifference point, 8s delay	0.2	0.3	0.5	-0.4	-0.5	0.3	0.5	-0.5	-0.7
Indifference point function ln k	0.0	0.1	0.1	-0.2	-0.3	0.2	0.4	-0.4	-0.1
Indifference point function log k	0.0	0.1	0.1	-0.2	-0.3	0.2	0.4	-0.4	-0.1
Patch foraging total patch changes 0 sec	2.1	4.0	4.8	-2.2	-2.0	2.1	2.2	-2.2	-1.2
Patch foraging total patch changes 12 sec	2.0	2.6	2.9	-1.7	-1.6	1.6	1.6	-1.6	-1.5
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	-0.1	-0.0	0.1	0.1	-0.1	0.1
Patch foraging total patch changes 24 sec	0.1	0.2	0.8	-0.6	-0.4	0.9	0.2	-0.2	-0.1
Patch foraging total patch changes 6 sec	1.6	2.4	3.2	-1.8	-1.5	1.5	1.6	-1.6	-1.0
Patch foraging time to switch 0 sec	0.0	0.0	0.2	-0.2	0.1	0.2	0.0	-0.0	0.4
Patch foraging water rate 0 sec	0.6	1.3	1.8	-1.1	-1.2	0.9	1.1	-1.1	-1.3
Patch foraging water rate 12 sec	0.8	1.7	2.0	-1.3	-1.4	1.1	1.2	-1.2	-1.4
Patch foraging water rate 18 sec	0.7	1.0	3.1	-0.7	-1.1	0.8	0.7	-0.7	-1.8
Patch foraging water rate 24 sec	3.0	4.3	7.6	-1.8	-2.2	1.6	1.9	-1.9	-2.8
Patch foraging water rate 6 sec	0.1	0.1	0.7	0.0	-0.2	-0.1	0.0	-0.0	-0.8
Seeking ratio, delayed vs. immediate footshock	1.7	2.0	2.4	1.5	1.5	-0.9	-1.6	1.6	1.4
Distance traveled before self-admin	1.2	1.6	1.7	1.3	1.3	-1.3	-1.3	1.3	1.1
Distance traveled after self-admin	0.0	0.0	0.1	0.3	0.1	0.0	-0.2	0.2	0.1
Extensor digitorum longus weight	5.2	20.6	22.0	-4.7	-4.6	4.7	4.6	-4.6	-3.9
Bone: elastic displacement	0.1	0.1	0.2	0.3	0.4	-0.2	-0.4	0.4	0.4
Bone: elastic work	0.1	0.1	0.3	-0.5	-0.3	0.4	0.3	-0.3	0.1
Bone: endosteal estimation	0.7	1.5	2.0	-1.2	-1.2	1.3	1.4	-1.4	-0.7
Bone: endosteal perimeter	0.3	0.6	1.3	0.7	0.8	-0.7	-0.5	0.5	1.2
Epididymis fat weight	0.0	0.1	0.5	-0.3	-0.3	0.1	0.2	-0.2	-0.7
Delta time in closed arm before/after self-admin	4.0	3.7	5.5	-1.6	-2.0	2.1	1.7	-1.7	-2.3
Delta time in open arm before/after self-admin	0.5	0.5	0.6	-0.8	-0.7	0.5	0.8	-0.8	-0.5
Diff in mean of infusions in LGA sessions	1.1	1.4	2.0	1.1	1.2	-1.4	-1.2	1.2	0.8
Delay discount exponential model param	0.0	0.0	0.1	-0.3	-0.2	0.0	0.2	-0.2	-0.2
Extinction: sum of active levers before priming	0.5	0.6	0.8	0.7	0.7	-0.9	-0.9	0.9	0.1
Active lever presses in extinction session 6	0.3	0.3	0.5	0.3	0.5	-0.7	-0.6	0.6	0.6
Bone: final force	1.3	2.0	3.0	-1.7	-1.3	1.4	1.6	-1.6	-0.4
Bone: final moment	1.1	1.8	2.7	-1.7	-1.3	1.3	1.5	-1.5	-0.4
Food consumed during 24 hour testing period	0.1	0.2	0.3	-0.4	-0.4	0.4	0.6	-0.6	-0.3
Glucose	1.2	1.8	3.0	-1.4	-1.3	1.7	1.3	-1.3	-1.0
Heart weight	0.0	0.0	0.1	0.1	0.1	-0.3	-0.1	0.1	-0.2
Delay discount hyperbolic model param	0.0	0.0	0.0	-0.1	-0.0	-0.2	0.0	-0.0	-0.2
Intermittent access intake day 1-15 change	0.0	0.1	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.2
Intermittent access intake escalation	0.0	0.1	0.1	0.1	0.2	-0.2	-0.3	0.3	-0.2
Intermittent access intake escalation 2	0.2	0.2	0.2	0.4	0.5	-0.4	-0.5	0.5	0.2
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.9	-0.1	-0.3	-0.3	0.3	-0.3	-1.0
Intermitt. access day 15 inactive lever presses	0.4	0.8	1.7	0.9	0.8	-1.3	-0.8	0.8	0.4
Intermitt. access escalation Index	0.2	0.2	0.5	0.5	0.4	-0.1	-0.5	0.5	0.7
Intermittent access day 1 total infusions	0.2	0.4	0.4	-0.5	-0.7	0.6	0.6	-0.6	-0.6
Intermittent access day 15 total infusions	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1	-0.1	-0.1
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.1	0.3	-0.3	-0.2	0.2	0.5
Intermittent access total infusions	0.1	0.1	0.2	-0.4	-0.3	0.2	0.3	-0.3	-0.1
Intermittent access day 1 locomotion	0.3	0.4	0.8	-0.5	-0.7	0.4	0.5	-0.5	-0.9
Intermittent access day 15 total locomotion	0.0	0.0	0.1	0.2	-0.0	-0.2	-0.2	0.2	-0.3
Intermittent access total locomotion	0.0	0.0	0.0	0.1	0.0	-0.2	-0.2	0.2	-0.1
Intermittent access standard deviation	0.4	0.8	1.0	0.9	0.9	-1.0	-0.9	0.9	0.9
Left kidney weight	0.0	0.1	0.1	0.3	0.0	0.1	-0.4	0.4	-0.2
Right kidney weight	0.1	0.5	0.8	0.8	0.6	-0.8	-0.9	0.9	0.0
Cocaine induced anxiety	2.4	3.5	4.1	1.7	1.9	-1.4	-2.0	2.0	2.0
Post-drug Anxiety	2.2	2.4	4.6	1.2	1.7	-0.8	-1.6	1.6	2.1
Baseline Anxiety	0.0	0.0	0.1	-0.1	-0.1	0.2	0.3	-0.3	-0.0
Tail length	3.0	11.7	14.4	3.8	3.4	-3.7	-3.6	3.6	2.2
Length with tail	1.1	4.6	6.1	2.5	2.1	-2.4	-2.3	2.3	1.0
Length without tail	0.3	1.0	1.3	-0.9	-1.1	1.0	1.0	-1.0	-1.1
Times rat made contact with spout	1.8	2.0	2.4	-1.5	-1.4	1.1	1.6	-1.6	-1.4
Lifetime Intake	0.4	0.5	0.8	-0.9	-0.7	0.7	0.7	-0.7	-0.3
Liver weight, left	0.2	0.3	0.4	-0.5	-0.6	0.5	0.5	-0.5	-0.5
Liver weight, right	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	-0.1	-0.3
Locomotor activity	5.2	8.0	9.1	2.8	2.9	-3.0	-2.8	2.8	2.7
Locomotor testing distance	2.0	3.7	4.1	1.8	2.0	-2.0	-1.9	1.9	1.9
Locomotor testing rearing	0.0	0.0	0.0	-0.1	-0.0	-0.2	0.2	-0.2	-0.2
Locomotion in novel chamber	0.1	0.1	0.2	-0.3	-0.3	0.4	0.1	-0.1	-0.2
Locomotion in novel chamber post-restriction	2.5	4.1	4.7	2.1	2.2	-1.9	-2.1	2.1	1.6
Fecal boli incidents, locomotor time 1	1.0	1.5	1.7	-1.2	-1.2	1.2	1.2	-1.2	-1.3
Change in fecal boli incidents, locomotor task	1.7	1.7	2.3	1.3	1.3	-1.2	-1.3	1.3	1.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.2	-0.1	0.2	0.3	-0.3	0.5
Bouts of movement, locomotor time 1	0.4	0.5	0.9	0.8	0.7	-1.0	-0.6	0.6	0.4
Total resting periods, locomotor time 1	1.2	1.3	1.8	1.3	1.2	-1.3	-1.1	1.1	0.8
Rest time, locomotor task time 1	0.9	1.1	1.1	1.0	1.0	-1.0	-1.1	1.1	1.0
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.5	-0.2	0.3	0.3	-0.3	0.4
Vertical activity count, locomotor time 1	0.5	1.3	1.6	-1.2	-1.2	1.2	1.0	-1.0	-0.9
Time >=10cm from walls, locomotor time 2	1.1	1.7	2.0	-1.1	-1.3	1.4	1.3	-1.3	-1.2
Bouts of movement, locomotor time 2	0.6	1.0	1.2	1.0	0.9	-1.1	-0.8	0.8	1.1
Total resting periods, locomotor time 2	0.6	1.1	1.6	1.1	1.0	-1.1	-0.9	0.9	1.2
Rest time, locomotor task time 2	0.4	0.5	0.8	0.7	0.7	-0.6	-0.6	0.6	0.9
Distance moved, locomotor task time 2	0.1	0.2	0.5	-0.4	-0.5	0.2	0.3	-0.3	-0.7
Vertical activity count, locomotor time 2	1.5	2.1	2.8	-1.4	-1.6	1.4	1.3	-1.3	-1.7
Light reinforcement 1	3.8	9.4	10.8	3.1	3.1	-3.3	-3.1	3.1	2.7
Light reinforcement 2	2.0	3.1	3.7	1.9	1.8	-1.9	-1.7	1.7	1.6
Bone: marrow area	0.7	1.5	2.0	-1.2	-1.1	1.3	1.4	-1.4	-0.7
Bone: maximum diameter	0.5	0.9	2.1	0.8	1.0	-0.8	-0.7	0.7	1.4
Bone: maximum force	1.4	2.5	3.6	-1.9	-1.5	1.6	1.8	-1.8	-0.6
Bone: maximum moment	1.3	2.3	3.4	-1.8	-1.5	1.6	1.7	-1.7	-0.6
Mean time between licks in bursts	0.1	0.4	0.6	0.7	0.6	-0.8	-0.5	0.5	0.3
Mean num. licks in bursts	0.8	1.3	1.7	1.1	1.2	-1.3	-1.0	1.0	1.2
Cd content in liver	0.1	0.1	0.1	0.2	0.3	-0.3	-0.3	0.3	0.4
Co content in liver	2.6	3.0	3.9	1.9	1.7	-2.0	-1.8	1.8	1.1
Cu content in liver	0.2	0.2	0.3	-0.4	-0.2	0.4	0.6	-0.6	0.3
Fe content in liver	0.6	0.7	0.8	-0.9	-0.9	0.7	0.9	-0.9	-0.9
K content in liver	1.6	1.5	1.8	1.2	1.3	-1.1	-1.2	1.2	1.4
Mg content in liver	1.4	1.4	1.6	1.2	1.2	-1.3	-1.1	1.1	1.1
Mn content in liver	3.5	3.9	6.1	1.9	2.0	-1.8	-1.8	1.8	2.5
Na content in liver	0.1	0.1	0.2	-0.4	-0.1	0.5	0.3	-0.3	0.2
Rb content in liver	0.1	0.1	0.3	-0.3	-0.0	0.2	0.5	-0.5	0.4
Se content in liver	0.0	0.0	0.0	-0.2	-0.2	0.2	0.1	-0.1	-0.1
Sr content in liver	0.1	0.1	0.3	0.3	0.2	-0.3	-0.5	0.5	-0.2
Zn content in liver	0.7	0.8	1.1	1.1	0.8	-1.1	-1.0	1.0	-0.2
Bone: minimum diameter	0.1	0.2	0.2	-0.4	-0.2	0.4	0.5	-0.5	0.5
Time in familiar zone, hab. session 1	2.7	2.6	3.5	1.9	1.6	-1.7	-1.7	1.7	0.9
Time in novel zone, hab. session 1	1.0	1.0	1.7	-1.3	-0.9	1.0	1.1	-1.1	-0.1
Total zone transitions, hab. session 1	1.1	1.6	2.8	1.1	1.3	-1.2	-1.1	1.1	1.7
Total locomotion distance, hab. session 1	3.7	5.2	7.4	2.2	2.4	-2.2	-2.1	2.1	2.7
Locomotion velocity, hab. session 1	3.5	5.0	6.4	2.2	2.3	-2.2	-2.1	2.1	2.5
Time in familiar zone, hab. session 2	4.2	4.4	5.8	2.3	1.9	-2.2	-2.4	2.4	1.0
Time in novel zone, hab. session 2	4.5	4.5	6.0	-2.4	-1.9	2.2	2.4	-2.4	-0.9
Total zone transitions, hab. session 2	0.3	0.4	1.8	0.1	0.4	-0.3	-0.2	0.2	1.3
Total locomotion distance, hab. session 2	1.7	2.2	3.0	1.4	1.5	-1.4	-1.5	1.5	1.7
Locomotion velocity, hab. session 2	2.2	2.9	4.3	1.6	1.7	-1.6	-1.6	1.6	2.1
Novel to familiar place preference ratio	1.2	1.3	1.9	-1.4	-1.0	1.2	1.3	-1.3	-0.2
Novelty place preference	0.7	0.8	1.1	-1.1	-0.7	0.9	1.0	-1.0	-0.0
Time in novel zone, NPP test	1.1	1.2	1.7	-1.3	-1.0	1.2	1.3	-1.3	-0.2
Total zone transitions, NPP test	0.1	0.1	0.4	0.0	0.2	-0.1	0.0	-0.0	0.7
Total locomotion distance, NPP test	0.4	0.6	1.4	0.6	0.7	-0.6	-0.6	0.6	1.2
Locomotion velocity, NPP test	0.7	1.0	1.8	0.9	1.0	-0.9	-0.9	0.9	1.3
Intraocular pressure	0.1	0.1	0.4	0.2	-0.0	-0.1	0.0	-0.0	-0.6
Delta distance traveled before/after self-admin	0.6	0.6	1.0	-0.6	-0.8	1.0	0.8	-0.8	-0.8
Delta ambulatory time before/after self-admin	0.3	0.3	0.6	-0.5	-0.6	0.8	0.6	-0.6	-0.3
Parametrial fat weight	0.3	0.6	1.2	-0.8	-0.8	1.1	0.8	-0.8	-0.5
Pavlov. Cond. lever latency	0.7	0.9	2.0	-0.6	-0.9	0.8	0.8	-0.8	-1.4
Pavlov. Cond. magazine entry latency	1.6	2.0	2.3	1.5	1.4	-1.5	-1.5	1.5	1.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.4	-0.3	0.4	0.2	-0.2	-0.2
Pavlov. Cond. index score	1.1	1.4	1.7	1.1	1.2	-1.2	-1.2	1.2	1.3
Pavlov. Cond. latency score	1.3	1.7	2.4	1.1	1.3	-1.2	-1.2	1.2	1.5
Pavlov. Cond. lever contacts	0.5	0.6	1.6	0.5	0.7	-0.7	-0.7	0.7	1.3
Pavlov. Cond. magazine entry number	0.5	0.7	0.8	-0.9	-0.8	0.9	0.9	-0.9	-0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.5	-0.1	-0.3	0.2	0.0	-0.0	-0.7
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.5	1.1	1.2	-1.2	-1.2	1.2	1.2
Pavlov. Cond. response bias	0.5	0.6	0.8	0.8	0.8	-0.8	-0.9	0.9	0.6
Pavlov. Cond. lever latency	1.5	2.1	2.8	-1.7	-1.5	1.4	1.5	-1.5	-1.0
Pavlov. Cond. magazine entry latency	2.4	2.9	3.6	1.9	1.7	-1.7	-1.8	1.8	1.2
Pavlov. Cond. change in total contacts	0.6	0.9	1.3	1.1	0.9	-0.9	-1.0	1.0	0.5
Pavlov. Cond. index score	1.7	2.2	3.1	1.7	1.5	-1.5	-1.5	1.5	1.0
Pavlov. Cond. latency score	2.1	2.8	3.6	1.9	1.7	-1.7	-1.7	1.7	1.2
Pavlov. Cond. lever contacts	1.1	1.5	2.2	1.5	1.3	-1.2	-1.3	1.3	0.7
Pavlov. Cond. magazine entry number	2.5	3.1	3.8	-2.0	-1.8	1.7	1.8	-1.8	-1.3
Pavlov. Cond. intertrial magazine entries	1.4	2.1	2.3	-1.5	-1.5	1.5	1.4	-1.4	-1.4
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.6	3.4	1.8	1.7	-1.6	-1.7	1.7	1.1
Pavlov. Cond. response bias	1.7	2.3	3.4	1.8	1.5	-1.5	-1.6	1.6	0.8
Time in closed arm before self-admin	0.1	0.2	0.6	0.3	0.4	-0.0	-0.2	0.2	0.8
Time in closed arm after self-admin	0.7	0.7	2.1	-0.5	-0.8	1.4	0.7	-0.7	-0.7
Time in open arm before self-admin	0.0	0.0	0.1	-0.3	-0.2	-0.1	0.2	-0.2	-0.2
Time in open arm after self-admin	1.7	1.8	2.4	-1.6	-1.4	0.8	1.5	-1.5	-1.3
Bone: periosteal estimation	0.5	1.0	1.5	-1.1	-0.8	1.0	1.2	-1.2	0.0
Bone: periosteal perimeter	0.2	0.3	1.3	0.3	0.5	-0.3	-0.2	0.2	1.1
Bone: post-yield work	0.8	1.2	1.4	-1.0	-1.1	1.1	1.2	-1.2	-0.9
Progressive ratio test 1 active lever presses	0.5	0.6	0.8	-0.9	-0.8	0.7	0.8	-0.8	-0.7
Progressive ratio test 1 breakpoint	0.5	0.6	0.9	-0.9	-0.8	0.7	0.8	-0.8	-0.7
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.4	0.3	0.3	-0.5	-0.6	0.6	0.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.1	0.2	-0.5	-0.3	0.3	0.2
Progressive ratio test 2 breakpoint	0.1	0.2	0.4	0.3	0.3	-0.6	-0.4	0.4	0.3
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.3	0.0	-0.3	-0.0	0.0	0.3
Incentive Sensitization - Responses	0.3	0.5	0.8	0.7	0.6	-0.9	-0.7	0.7	0.4
Incentive Sensitization - Breakpoint	0.6	0.8	1.2	0.9	0.8	-1.1	-0.9	0.9	0.6
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	0.2	-0.0	-0.2	0.2	0.1
Progressive ratio	1.2	1.9	2.3	-1.3	-1.5	1.0	1.5	-1.5	-1.4
Food seeking constrained by brief footshock	1.4	1.7	2.0	1.3	1.3	-1.4	-1.4	1.4	0.9
Seeking ratio, punishment vs. effort	2.1	3.1	3.8	1.8	1.8	-1.5	-1.9	1.9	1.4
Retroperitoneal fat weight	2.6	11.2	13.4	-3.3	-3.5	3.7	3.2	-3.2	-3.3
Reaction time number correct	1.2	2.3	3.1	-1.4	-1.6	1.4	1.5	-1.5	-1.8
Reaction time mean minus median	0.8	1.9	2.3	1.5	1.4	-1.1	-1.5	1.5	1.1
Reaction time mean minus median AUC	1.4	3.4	4.0	1.9	1.9	-1.5	-1.9	1.9	2.0
Reaction time num false alarms	0.3	0.4	0.6	-0.6	-0.8	0.4	0.6	-0.6	-0.6
Reaction time num false alarms AUC	0.3	0.5	0.7	-0.6	-0.8	0.5	0.7	-0.7	-0.8
Reaction time trials correct on left	1.2	2.3	3.1	-1.4	-1.6	1.4	1.5	-1.5	-1.8
Reaction time trials on left	1.2	2.2	2.8	-1.3	-1.6	1.4	1.4	-1.4	-1.7
Reaction time mean	1.3	2.1	2.6	1.5	1.5	-1.2	-1.4	1.4	1.6
Reaction time mean AUC	0.6	0.9	1.6	1.0	1.0	-0.6	-0.9	0.9	1.2
Median of all reaction times	0.9	1.2	1.9	1.1	1.2	-0.9	-1.0	1.0	1.4
Reaction time omissions	0.1	0.1	0.3	0.3	0.3	0.1	-0.4	0.4	0.6
Reaction time false alarm rate	0.0	0.0	0.1	0.1	0.1	-0.2	-0.1	0.1	0.2
Reaction time premature initiation rate	1.0	1.5	2.0	1.2	1.0	-1.4	-1.4	1.4	0.4
Reaction time premature initiations	0.1	0.2	0.4	0.4	0.1	-0.5	-0.5	0.5	-0.6
Std. dev. reaction times	0.7	1.3	1.5	1.2	1.2	-0.8	-1.2	1.2	1.2
Reaction time trials completed	1.2	2.2	2.8	-1.3	-1.6	1.4	1.4	-1.4	-1.7
Reaction time trials AUC	1.4	2.6	3.6	-1.5	-1.7	1.4	1.6	-1.6	-1.9
Run reversals in cocaine runway, females	3.5	3.5	3.9	2.0	1.8	-2.0	-1.9	1.9	1.7
Run reversals in cocaine runway, males	2.7	2.7	3.0	1.6	1.7	-1.3	-1.7	1.7	1.7
Latency to leave start box in cocaine runway	0.4	0.5	1.2	0.5	0.7	-0.3	-0.6	0.6	1.1
Latency to leave start box in cocaine runway, F	0.4	0.5	1.8	0.4	0.7	-0.2	-0.5	0.5	1.3
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.0	-0.1	-0.0	-0.1	0.1	-0.3
Std. dev. time between licks in bursts	0.8	1.0	1.6	1.0	1.1	-1.0	-0.8	0.8	1.2
Total sessions with >9 infusions	0.3	0.3	0.8	-0.7	-0.6	0.9	0.4	-0.4	-0.2
Short access day 1 total inactive lever presses	0.1	0.1	0.2	0.5	0.2	-0.5	-0.3	0.3	-0.1
Short access day 10 total inactive lever presses	0.2	0.4	1.5	-0.3	-0.6	0.3	0.5	-0.5	-1.2
Short access day 1 total infusions	0.3	0.4	0.7	-0.8	-0.7	0.9	0.6	-0.6	-0.3
Short access day 10 total infusions	0.2	0.3	0.4	-0.5	-0.6	0.6	0.5	-0.5	-0.5
Short access total infusions	0.4	0.5	0.7	-0.9	-0.8	0.8	0.7	-0.7	-0.3
Short access day 1 locomotion	0.1	0.1	0.3	0.4	0.2	-0.3	-0.5	0.5	-0.0
Short access day 10 total locomotion	0.1	0.3	0.6	0.5	0.3	-0.7	-0.5	0.5	-0.4
Short access total locomotion	0.0	0.1	0.1	0.2	0.1	-0.1	-0.3	0.3	-0.2
One hour access (0.3 mA shock)	0.2	0.3	0.5	-0.7	-0.6	0.4	0.4	-0.4	-0.6
Compulsive drug intake	0.1	0.1	0.1	0.4	0.3	-0.1	-0.4	0.4	0.4
One hour access (shock baseline)	0.0	0.0	0.1	-0.2	-0.1	-0.1	0.0	-0.0	-0.2
Social response proportion	1.4	1.6	2.7	1.3	1.2	-1.6	-1.2	1.2	1.1
Social responses	10.1	13.0	16.1	3.7	3.7	-4.0	-3.6	3.6	3.1
Social time	1.2	1.6	1.8	-1.3	-1.3	1.2	1.3	-1.3	-1.2
Soleus weight	4.0	11.9	14.8	-3.8	-3.5	3.8	3.4	-3.4	-2.5
Bone: stiffness	3.2	5.2	6.7	-2.6	-2.3	2.2	2.5	-2.5	-1.4
Tibialis anterior weight	1.3	4.4	5.7	-2.3	-2.0	2.4	2.2	-2.2	-1.4
Time to tail flick, vehicle, before self-admin	1.6	1.7	2.1	1.4	1.4	-0.6	-1.4	1.4	1.5
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.5	0.1	-0.1	-0.3	-0.0	0.0	-0.7
Time to tail flick, test, before self-admin	1.8	1.8	2.3	1.4	1.3	-1.2	-1.4	1.4	1.5
Time to tail flick, test, after self-admin	0.0	0.0	0.2	0.1	0.2	0.1	0.0	-0.0	0.4
Delta time to tail flick, vehicle, before/after SA	2.6	2.5	3.6	-1.5	-1.6	0.9	1.7	-1.7	-1.9
Delta time to tail flick, test, before/after SA	0.6	0.6	1.1	-0.7	-0.7	0.6	0.8	-0.8	-1.0
Tibia length	0.7	1.8	2.4	1.5	1.4	-1.6	-1.4	1.4	0.7
Ambulatory time before self-admin	0.2	0.3	0.5	0.5	0.6	-0.7	-0.6	0.6	0.5
Ambulatory time after self-admin	0.0	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	0.1
Bone: tissue strength	4.2	4.2	5.7	-2.4	-2.0	2.2	2.2	-2.2	-1.2
Total heroin consumption	2.6	3.0	3.3	1.7	1.7	-1.7	-1.8	1.8	1.5
Bone: trabecular number	1.1	1.8	3.3	1.1	1.4	-1.1	-1.3	1.3	1.8
Bone: trabecular spacing	1.0	1.4	3.6	-0.8	-1.2	0.8	1.0	-1.0	-1.9
Bone: trabecular thickness	1.3	1.6	5.4	0.7	1.3	-1.0	-0.8	0.8	2.3
Bone: trabecular tissue density	5.9	8.7	9.4	-3.1	-3.0	3.0	2.9	-2.9	-2.6
Water consumed over 24 hours	0.2	0.2	0.4	-0.6	-0.3	0.4	0.6	-0.6	0.2
Number of responses in last shaping day	0.8	0.9	1.4	0.9	0.9	-1.0	-1.2	1.2	0.4