LOC134479568

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC134479568	0.11	0.11	6.3e-05	0.03	0.04	0.02	0.03	2.6e-04	8.9e-05	6.8e-03	4.6e-04
2	Brain	gene expression	LOC134479568	0.04	0.04	1.6e-04	0.04	0.04	0.04	0.04	1.0e-04	8.5e-05	1.0e-04	1.1e-04
3	pVTA	gene expression	LOC134479568	0.05	0.04	1.9e-04	0.02	0.03	0.02	0.03	5.9e-03	8.7e-04	7.2e-03	3.0e-03
4	IC	gene expression	LOC134479568	0.08	0.06	3.5e-03	0.04	0.04	0.03	0.03	7.0e-03	8.4e-03	2.3e-02	1.6e-02
5	BLA	gene expression	LOC134479568	0.36	0.22	3.6e-03	0.01	0.04	0.05	0.04	1.2e-01	4.4e-03	1.8e-03	4.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	6.6	12.3	12.9	3.5	3.6	3.6	-3.5	-3.3
Area under the delay curve	1.2	1.8	2.3	1.3	1.3	1.3	-1.4	-1.5
BMI with tail	6.9	24.1	25.7	5.1	5.0	5.0	-4.7	-4.8
BMI without tail	1.2	6.5	7.2	2.6	2.7	2.7	-2.4	-2.3
Body weight	7.5	32.9	38.2	6.2	5.8	5.8	-5.5	-5.4
Weight adjusted by age	1.4	4.1	6.8	2.6	2.0	2.0	-2.1	-0.9
Bone surface	8.4	16.6	18.1	4.1	4.3	4.2	-4.2	-3.5
Bone volume	5.8	11.6	12.4	3.5	3.5	3.5	-3.4	-3.0
Breakpoint value in progressive ratio session	0.5	1.0	1.2	0.7	1.1	1.1	-1.0	-1.0
Number of licking bursts	0.1	0.4	1.3	-0.5	-0.4	-0.5	0.5	1.1
Context. condit. distance diff. score	0.5	0.6	0.7	0.7	0.8	0.8	-0.9	-0.8
Locomotion velocity, session 1	0.5	0.5	1.3	-0.4	-0.7	-0.7	0.5	1.2
Locomotion distance, session 1	2.3	2.9	3.5	-1.6	-1.9	-1.8	1.8	1.3
Locomotion velocity, session 2	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.6	0.3
Locomotion distance, session 2	2.0	2.8	3.2	-1.7	-1.8	-1.8	1.8	1.2
Locomotion velocity, session 3	2.7	3.2	3.9	-1.8	-1.9	-1.9	2.0	1.2
Locomotion distance, session 3	4.4	5.1	6.0	-2.5	-2.4	-2.4	2.4	1.5
Stereotopy head waving bouts, day 3	0.6	0.7	0.9	0.9	0.9	0.9	-0.9	-0.4
Stereotopy head waving duration, day 3	0.2	0.3	0.3	0.5	0.6	0.6	-0.6	-0.1
Locomotion velocity, session 7	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.4	0.0
Locomotion distance, session 7	1.0	1.2	1.8	-0.9	-1.2	-1.2	1.3	1.0
Stereotopy head waving bouts, day 7	1.0	1.2	1.6	1.0	1.2	1.2	-1.2	-0.7
Stereotopy head waving duration, day 7	1.2	1.4	1.9	1.0	1.3	1.3	-1.4	-0.8
Locomotion velocity, session 8	0.2	0.3	0.6	0.3	0.4	0.4	-0.5	-0.8
Locomotion distance, session 8	0.7	1.1	1.5	-1.2	-1.2	-1.1	1.1	0.3
Degree of sensitization distance	0.8	0.8	1.5	1.2	0.9	0.9	-0.8	-0.4
Degree of sensitization stereotypy	0.3	0.4	0.5	0.5	0.7	0.7	-0.7	-0.3
Conditioned locomotion	0.4	0.4	2.0	0.0	-0.1	-0.1	0.2	1.4
Cocaine response after cond. corrected	0.3	0.4	1.6	0.4	0.2	0.3	-0.3	-1.3
Cocaine response after cond. not corrected	0.4	0.6	0.9	-0.8	-0.9	-0.9	0.9	-0.1
Cocaine response before conditioning	7.8	9.4	11.1	-3.3	-3.0	-3.0	2.9	3.1
Saline control response	0.1	0.2	0.4	-0.6	-0.4	-0.4	0.3	0.3
Bone: connectivity density	4.9	7.9	8.3	2.8	2.9	2.9	-2.9	-2.6
Bone: cortical apparent density	0.4	0.7	1.0	-0.9	-0.7	-0.7	0.7	1.0
Bone: cortical area	10.1	16.4	17.6	4.2	4.2	4.2	-4.0	-3.7
Bone: cortical porosity	2.5	2.7	3.1	-1.7	-1.6	-1.6	1.8	1.6
Bone: cortical porosity	2.6	2.9	3.6	-1.9	-1.6	-1.6	1.7	1.6
Bone: cortical thickness	4.4	7.4	8.0	2.7	2.8	2.8	-2.7	-2.5
Bone: cortical thickness	0.5	0.6	0.9	0.9	0.7	0.7	-0.6	-0.9
Bone: cortical tissue density	0.5	0.8	1.2	-1.0	-0.8	-0.8	0.8	1.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.2	-0.3	-0.3	0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.0	0.5	0.3	0.4	-0.4	-1.0
Condit. Reinf. active responses	0.4	0.5	0.7	-0.6	-0.9	-0.8	0.8	0.4
Condit. Reinf. inactive responses	2.5	3.3	4.0	-1.6	-1.8	-1.8	1.7	2.0
Incentive salience index mean	0.0	0.0	0.1	0.1	0.1	0.1	-0.2	-0.3
Condit. Reinf. lever presses	0.2	0.2	0.5	0.4	0.5	0.5	-0.7	-0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	-0.0	-0.1	-0.1	0.0	0.6
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.4	-0.1	-0.5	-0.5	0.4	0.6
Condit. Reinf. active responses	0.4	0.5	1.1	-0.7	-0.6	-0.6	0.4	1.1
Condit. Reinf. inactive responses	1.0	1.5	2.5	-1.3	-1.1	-1.1	1.0	1.6
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.4	-0.0	-0.0	-0.0	0.1
Condit. Reinf. lever reinforcers received	0.6	0.9	1.5	-1.0	-0.9	-0.9	0.7	1.2
Conditioned reinforcement - actives	0.2	0.9	1.5	-1.2	-0.8	-0.8	0.9	0.9
Conditioned reinforcement - inactives	1.3	3.4	3.9	-1.9	-1.9	-1.9	2.0	1.6
Conditioned locomotion	0.4	0.5	1.4	-1.2	-0.3	-0.4	0.3	1.0
Patch foraging indifference point 0 sec	0.7	2.1	2.5	-1.4	-1.6	-1.6	1.5	1.2
Patch foraging indifference point AUC	0.4	1.0	1.3	-1.1	-0.9	-0.9	0.8	1.1
Delay disc. indifference point, 0s delay	1.5	1.7	2.0	1.4	1.4	1.3	-1.4	-0.8
Delay disc. indifference point, 16s delay	1.2	1.6	2.0	1.3	1.3	1.3	-1.4	-1.2
Delay disc. indifference point, 2s delay	0.9	1.0	1.4	1.2	1.0	1.0	-1.1	-0.8
Delay disc. indifference point, 24s delay	0.8	1.3	1.6	1.2	1.2	1.2	-1.3	-1.0
Delay disc. indifference point, 4s delay	0.9	0.9	1.9	1.0	0.8	0.8	-0.7	-1.4
Delay disc. indifference point, 8s delay	2.3	3.9	5.1	1.8	1.9	1.9	-2.0	-2.3
Indifference point function ln k	1.5	4.6	6.5	2.6	2.2	2.2	-2.1	-1.5
Indifference point function log k	1.5	4.6	6.5	2.6	2.2	2.2	-2.1	-1.5
Patch foraging total patch changes 0 sec	0.8	2.2	2.5	-1.5	-1.6	-1.6	1.5	1.3
Patch foraging total patch changes 12 sec	1.6	2.1	3.1	-1.8	-1.4	-1.4	1.3	1.3
Patch foraging total patch changes 18 sec	2.0	4.6	5.2	-2.3	-2.1	-2.1	2.0	2.3
Patch foraging total patch changes 24 sec	0.5	1.8	2.5	-1.4	-1.3	-1.2	1.1	1.6
Patch foraging total patch changes 6 sec	2.1	3.5	4.0	-2.0	-2.0	-2.0	1.9	1.6
Patch foraging time to switch 0 sec	1.4	5.3	6.1	-2.5	-2.3	-2.3	2.3	2.2
Patch foraging water rate 0 sec	2.0	7.5	8.1	2.7	2.8	2.8	-2.8	-2.4
Patch foraging water rate 12 sec	1.3	5.1	5.5	2.3	2.3	2.3	-2.4	-1.9
Patch foraging water rate 18 sec	0.5	1.1	1.3	1.0	1.1	1.1	-1.2	-0.7
Patch foraging water rate 24 sec	2.6	3.7	4.7	1.5	2.2	2.1	-2.1	-1.5
Patch foraging water rate 6 sec	4.9	7.2	8.9	2.6	2.8	2.8	-3.0	-2.2
Seeking ratio, delayed vs. immediate footshock	0.4	0.6	1.9	0.6	0.4	0.4	-0.6	-1.4
Distance traveled before self-admin	0.4	0.8	1.6	-0.9	-0.8	-0.8	0.6	1.3
Distance traveled after self-admin	0.2	0.4	1.5	-1.2	-0.4	-0.4	0.3	0.0
Extensor digitorum longus weight	6.0	24.0	26.9	5.2	5.0	5.1	-5.2	-3.9
Bone: elastic displacement	4.7	6.0	7.2	-2.7	-2.4	-2.4	2.4	2.3
Bone: elastic work	0.1	0.1	0.3	-0.5	-0.3	-0.3	0.3	0.3
Bone: endosteal estimation	6.6	16.2	17.9	4.2	4.1	4.2	-4.1	-3.5
Bone: endosteal perimeter	6.2	15.2	16.5	4.1	4.0	4.0	-3.9	-3.6
Epididymis fat weight	0.9	4.3	5.3	1.8	2.2	2.2	-2.3	-1.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3	-0.4
Delta time in open arm before/after self-admin	0.7	0.8	1.3	-0.9	-0.9	-0.9	0.6	1.2
Diff in mean of infusions in LGA sessions	0.5	0.8	1.4	1.2	0.8	0.9	-0.6	-1.0
Delay discount exponential model param	1.2	1.6	2.1	-1.3	-1.1	-1.1	1.2	1.4
Extinction: sum of active levers before priming	1.0	1.4	1.9	1.4	1.3	1.3	-1.2	-0.7
Active lever presses in extinction session 6	1.3	1.3	1.7	1.2	1.1	1.1	-1.0	-1.3
Bone: final force	10.1	16.5	17.7	4.2	4.1	4.1	-4.1	-3.8
Bone: final moment	10.7	17.2	18.3	4.3	4.2	4.2	-4.2	-3.8
Food consumed during 24 hour testing period	0.9	1.8	3.0	1.2	1.2	1.2	-1.2	-1.7
Glucose	0.2	0.3	0.5	0.7	0.6	0.6	-0.5	-0.2
Heart weight	0.2	0.3	0.5	0.5	0.5	0.5	-0.7	-0.5
Delay discount hyperbolic model param	1.1	1.4	2.0	-1.2	-1.1	-1.1	1.1	1.4
Intermittent access intake day 1-15 change	0.0	0.0	0.2	-0.0	-0.0	-0.1	-0.0	-0.4
Intermittent access intake escalation	0.0	0.2	0.5	0.4	0.3	0.3	-0.4	-0.7
Intermittent access intake escalation 2	0.0	0.0	0.2	-0.1	-0.0	-0.0	-0.1	-0.4
Intermitt. access day 1 inactive lever presses	0.2	2.7	6.1	-1.3	-1.4	-1.4	1.4	2.5
Intermitt. access day 15 inactive lever presses	0.2	1.3	1.6	-0.9	-1.1	-1.1	1.1	1.3
Intermitt. access escalation Index	0.2	0.5	1.0	1.0	0.7	0.7	-0.3	-0.5
Intermittent access day 1 total infusions	0.4	1.1	1.8	-0.8	-1.1	-1.1	1.4	0.7
Intermittent access day 15 total infusions	0.1	0.4	0.6	-0.4	-0.6	-0.6	0.7	0.5
Intermittent access terminal intake (last 3 days)	0.5	0.9	1.2	-0.8	-1.0	-1.0	1.1	0.8
Intermittent access total infusions	1.0	1.2	1.7	-1.0	-1.1	-1.1	1.3	1.0
Intermittent access day 1 locomotion	0.1	0.2	0.6	-0.2	-0.1	-0.2	0.4	0.8
Intermittent access day 15 total locomotion	0.0	0.2	0.7	-0.2	-0.1	-0.1	0.1	0.8
Intermittent access total locomotion	0.7	0.9	2.2	-1.0	-0.7	-0.7	0.7	1.5
Intermittent access standard deviation	0.0	0.2	0.5	-0.3	-0.5	-0.5	0.7	0.1
Left kidney weight	0.9	7.3	11.0	3.0	2.4	2.4	-2.3	-3.3
Right kidney weight	3.6	25.0	32.3	5.7	4.9	4.9	-4.9	-4.6
Cocaine induced anxiety	1.2	3.4	4.2	1.7	2.0	2.0	-1.9	-1.4
Post-drug Anxiety	3.0	3.5	4.0	1.5	2.0	2.0	-2.0	-1.8
Baseline Anxiety	0.1	0.2	0.6	0.4	0.3	0.4	-0.5	-0.7
Tail length	0.0	0.2	0.3	0.6	0.4	0.4	-0.5	-0.3
Length with tail	2.0	8.9	11.4	3.4	2.9	2.9	-3.0	-2.7
Length without tail	4.6	24.0	26.1	5.1	4.7	4.8	-4.8	-5.0
Times rat made contact with spout	0.2	0.2	0.7	0.3	0.3	0.3	-0.4	-0.8
Lifetime Intake	1.0	1.3	1.8	-1.1	-1.1	-1.1	1.3	1.0
Liver weight, left	7.4	12.9	13.8	3.6	3.7	3.7	-3.6	-3.3
Liver weight, right	2.8	4.9	5.9	2.4	2.2	2.2	-2.3	-1.9
Locomotor activity	1.0	1.6	1.8	-1.3	-1.2	-1.2	1.3	1.3
Locomotor testing distance	1.7	4.2	4.5	-2.0	-2.0	-2.0	2.1	2.0
Locomotor testing rearing	1.1	4.0	5.0	-1.8	-2.0	-2.0	1.9	2.2
Locomotion in novel chamber	1.8	2.4	3.2	1.8	1.5	1.5	-1.7	-1.1
Locomotion in novel chamber post-restriction	0.1	0.3	0.6	0.3	0.5	0.5	-0.8	-0.4
Fecal boli incidents, locomotor time 1	0.3	0.7	1.3	-1.1	-0.8	-0.8	0.6	-0.5
Change in fecal boli incidents, locomotor task	0.6	0.6	1.6	1.3	0.6	0.6	-0.7	-0.1
Time >=10cm from walls, locomotor time 1	0.6	0.7	1.5	0.4	0.7	0.7	-1.0	-1.2
Bouts of movement, locomotor time 1	0.2	0.2	0.7	0.4	0.4	0.4	-0.1	-0.8
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.2	-0.2	-0.2	0.5	-0.4
Rest time, locomotor task time 1	0.1	0.1	0.2	0.0	-0.3	-0.2	0.5	-0.4
Distance moved, locomotor task time 1	0.1	0.3	0.6	-0.8	-0.4	-0.4	0.1	0.8
Vertical activity count, locomotor time 1	0.2	1.4	2.4	1.1	1.1	1.1	-1.0	-1.5
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.5	-0.7	-0.6	-0.6	0.7	0.3
Bouts of movement, locomotor time 2	1.0	3.4	4.1	2.0	2.0	2.0	-1.9	-1.1
Total resting periods, locomotor time 2	0.9	3.7	4.3	2.1	2.1	2.1	-2.1	-1.1
Rest time, locomotor task time 2	0.2	0.3	0.6	0.8	0.4	0.4	-0.5	-0.7
Distance moved, locomotor task time 2	0.4	0.6	0.9	-0.9	-0.6	-0.6	0.7	0.9
Vertical activity count, locomotor time 2	0.1	0.2	0.3	0.5	0.5	0.6	-0.2	-0.3
Light reinforcement 1	1.4	6.4	8.6	-2.7	-2.3	-2.4	2.3	2.9
Light reinforcement 2	0.5	1.1	1.3	-0.9	-1.1	-1.1	1.1	1.1
Bone: marrow area	6.6	16.1	17.8	4.2	4.1	4.2	-4.1	-3.4
Bone: maximum diameter	4.8	9.7	11.5	3.4	3.2	3.2	-3.0	-2.8
Bone: maximum force	11.7	23.2	25.2	5.0	4.9	4.9	-4.8	-4.3
Bone: maximum moment	12.4	23.5	25.5	5.0	5.0	5.0	-4.9	-4.4
Mean time between licks in bursts	0.2	1.0	1.1	-1.0	-0.9	-0.9	1.0	1.0
Mean num. licks in bursts	0.1	0.4	1.7	0.2	0.1	0.2	-0.3	-1.3
Cd content in liver	0.4	0.5	0.8	-0.2	-0.9	-0.9	0.9	0.1
Co content in liver	0.0	0.1	0.1	-0.3	-0.2	-0.2	0.2	0.3
Cu content in liver	2.3	2.7	2.9	1.6	1.7	1.7	-1.7	-1.6
Fe content in liver	1.4	1.8	1.9	-1.4	-1.3	-1.3	1.4	1.2
K content in liver	1.2	1.2	1.4	1.2	1.0	1.0	-1.2	-1.0
Mg content in liver	0.0	0.0	0.1	0.2	0.0	0.0	-0.2	-0.3
Mn content in liver	0.1	0.1	0.2	0.5	0.2	0.2	-0.3	0.3
Na content in liver	0.1	0.1	0.3	0.4	0.3	0.4	-0.5	0.3
Rb content in liver	0.1	0.2	0.3	0.5	0.4	0.4	-0.5	-0.1
Se content in liver	0.6	0.7	0.9	-0.9	-0.9	-0.9	0.8	0.7
Sr content in liver	1.9	1.6	2.0	1.2	1.4	1.4	-1.4	-1.0
Zn content in liver	0.1	0.2	0.4	-0.2	-0.4	-0.4	0.2	0.7
Bone: minimum diameter	7.7	14.8	16.2	4.0	4.0	4.0	-3.8	-3.4
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.2	-0.4	-0.4	0.4	-0.3
Time in novel zone, hab. session 1	0.1	0.1	0.3	0.0	0.3	0.2	-0.2	0.6
Total zone transitions, hab. session 1	0.4	0.5	0.7	-0.8	-0.6	-0.7	0.6	0.8
Total locomotion distance, hab. session 1	0.0	0.1	0.1	-0.4	-0.2	-0.2	0.3	0.0
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.2	-0.1	-0.1	0.2	-0.0
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.3	0.2	0.2	-0.2	-0.4
Time in novel zone, hab. session 2	0.1	0.1	0.5	-0.3	-0.1	-0.1	0.1	0.7
Total zone transitions, hab. session 2	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.3	0.2
Total locomotion distance, hab. session 2	0.1	0.2	0.4	-0.2	-0.4	-0.4	0.7	0.1
Locomotion velocity, hab. session 2	0.0	0.1	0.2	0.0	-0.2	-0.1	0.4	-0.1
Novel to familiar place preference ratio	0.7	0.9	1.6	1.3	1.1	1.1	-0.9	-0.3
Novelty place preference	0.4	0.5	0.9	0.9	0.8	0.8	-0.5	0.0
Time in novel zone, NPP test	0.3	0.3	0.6	0.8	0.7	0.6	-0.4	0.2
Total zone transitions, NPP test	0.8	1.2	1.6	-1.3	-1.2	-1.2	1.1	0.8
Total locomotion distance, NPP test	2.2	3.1	3.8	-1.8	-1.8	-1.8	1.9	1.3
Locomotion velocity, NPP test	1.1	1.6	2.2	-1.2	-1.3	-1.3	1.5	0.8
Intraocular pressure	10.3	16.7	21.6	-4.6	-3.9	-3.9	4.1	3.9
Delta distance traveled before/after self-admin	0.2	0.2	0.9	-0.2	0.1	0.1	-0.0	-0.9
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.5	-0.0	-0.0	0.1	-0.5
Parametrial fat weight	0.4	1.0	1.9	-1.4	-0.8	-0.9	1.1	0.5
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.4	0.2	0.2	-0.2	-0.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.4	-0.3	-0.3	0.5	-0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.0	0.1	0.0	0.0	-0.1
Pavlov. Cond. index score	0.0	0.1	0.1	0.1	0.3	0.3	-0.1	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.1	0.2	0.2	-0.1	-0.2
Pavlov. Cond. lever contacts	0.4	0.4	0.7	-0.8	-0.6	-0.6	0.6	0.6
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.2	-0.0	-0.0	-0.2	0.3
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	-0.6	-0.7	-0.7	0.5	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	0.4	0.6	0.6	-0.4	-0.6
Pavlov. Cond. response bias	0.1	0.2	0.3	-0.6	-0.4	-0.4	0.5	0.1
Pavlov. Cond. lever latency	0.2	0.3	0.8	0.9	0.5	0.5	-0.5	-0.2
Pavlov. Cond. magazine entry latency	0.2	0.3	0.3	0.6	0.5	0.5	-0.4	-0.5
Pavlov. Cond. change in total contacts	0.5	1.2	1.4	1.0	1.2	1.2	-1.1	-1.1
Pavlov. Cond. index score	0.1	0.2	0.3	0.3	0.5	0.5	-0.4	-0.5
Pavlov. Cond. latency score	0.1	0.2	0.3	0.3	0.5	0.5	-0.4	-0.4
Pavlov. Cond. lever contacts	0.1	0.2	0.5	-0.7	-0.3	-0.3	0.4	0.1
Pavlov. Cond. magazine entry number	1.1	1.5	1.7	-1.3	-1.3	-1.3	1.2	1.0
Pavlov. Cond. intertrial magazine entries	2.1	4.5	5.9	-2.4	-2.2	-2.2	2.1	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	0.4	0.7	0.6	-0.6	-0.5
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.3	-0.0	-0.1	0.1	-0.1
Time in closed arm before self-admin	1.1	2.0	3.4	1.8	1.5	1.5	-1.3	-0.7
Time in closed arm after self-admin	0.1	0.1	0.3	0.5	0.1	0.1	0.0	0.0
Time in open arm before self-admin	0.0	0.0	0.0	0.1	-0.0	-0.0	0.1	0.2
Time in open arm after self-admin	0.0	0.0	0.2	-0.1	-0.1	-0.1	-0.1	0.4
Bone: periosteal estimation	11.1	26.3	28.5	5.3	5.3	5.3	-5.1	-4.6
Bone: periosteal perimeter	10.7	21.0	22.9	4.8	4.6	4.6	-4.4	-4.5
Bone: post-yield work	7.0	12.1	13.6	3.6	3.6	3.6	-3.7	-2.8
Progressive ratio test 1 active lever presses	3.0	5.2	6.6	-2.6	-2.0	-2.1	2.3	2.5
Progressive ratio test 1 breakpoint	2.7	4.7	6.0	-2.5	-1.9	-1.9	2.1	2.4
Progressive ratio test 1 inactive lever presses	0.5	1.4	2.2	-0.7	-1.1	-1.1	1.3	1.5
Progressive ratio test 2 active lever presses	1.0	1.4	2.7	-1.0	-1.0	-1.0	1.1	1.6
Progressive ratio test 2 breakpoint	1.0	1.3	2.7	-0.9	-1.0	-1.0	1.1	1.6
Progressive ratio test 2 inactive lever presses	0.5	1.7	2.5	-1.0	-1.1	-1.2	1.5	1.6
Incentive Sensitization - Responses	0.2	0.6	1.8	1.3	0.7	0.7	-0.6	-0.4
Incentive Sensitization - Breakpoint	0.2	0.5	1.5	1.2	0.5	0.6	-0.5	-0.2
Sum of active levers in priming session hrs 5-6	0.1	0.0	0.1	-0.2	-0.2	-0.2	0.2	0.3
Progressive ratio	0.0	0.1	0.1	-0.3	-0.4	-0.3	-0.1	-0.0
Food seeking constrained by brief footshock	0.2	0.2	0.8	-0.9	-0.3	-0.3	0.0	0.1
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.3	0.0	0.0	0.2	0.2
Retroperitoneal fat weight	0.0	0.2	0.3	-0.5	-0.4	-0.4	0.5	0.0
Reaction time number correct	0.1	0.5	0.6	0.5	0.8	0.8	-0.6	-0.8
Reaction time mean minus median	1.7	10.7	12.8	-3.4	-3.6	-3.6	3.5	2.2
Reaction time mean minus median AUC	1.1	7.5	9.0	-2.9	-3.0	-3.0	2.8	1.8
Reaction time num false alarms	1.3	2.2	3.0	-1.4	-1.5	-1.5	1.7	1.2
Reaction time num false alarms AUC	1.5	3.5	4.8	-1.8	-2.0	-2.0	2.2	1.3
Reaction time trials correct on left	0.1	0.5	0.6	0.5	0.8	0.8	-0.6	-0.8
Reaction time trials on left	0.1	0.3	0.4	0.3	0.6	0.6	-0.5	-0.7
Reaction time mean	0.5	1.0	1.8	-1.3	-1.1	-1.1	0.8	0.6
Reaction time mean AUC	0.2	0.6	1.2	-1.1	-0.8	-0.8	0.6	0.2
Median of all reaction times	0.0	0.0	0.1	-0.3	0.1	0.1	-0.3	-0.2
Reaction time omissions	7.8	12.7	15.2	-3.9	-3.8	-3.8	3.5	2.7
Reaction time false alarm rate	1.8	2.5	3.2	-1.4	-1.7	-1.7	1.8	1.2
Reaction time premature initiation rate	3.2	5.0	7.1	-2.7	-2.2	-2.2	1.9	2.2
Reaction time premature initiations	1.1	3.3	5.3	-2.3	-1.7	-1.7	1.5	1.7
Std. dev. reaction times	2.5	8.5	10.0	-3.1	-3.2	-3.1	3.0	2.1
Reaction time trials completed	0.1	0.3	0.4	0.3	0.6	0.6	-0.5	-0.7
Reaction time trials AUC	0.2	0.8	1.0	0.7	1.0	1.0	-0.8	-0.9
Run reversals in cocaine runway, females	0.3	0.3	0.6	-0.1	-0.5	-0.5	0.8	0.6
Run reversals in cocaine runway, males	0.8	0.9	1.2	-0.8	-1.0	-0.9	1.1	0.9
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.3	-0.2	-0.2	-0.0	0.5
Latency to leave start box in cocaine runway, F	1.3	1.7	2.9	-1.3	-1.2	-1.2	1.0	1.7
Latency to leave start box in cocaine runway, M	2.2	2.1	2.8	1.3	1.4	1.4	-1.7	-1.5
Std. dev. time between licks in bursts	0.9	1.7	2.4	-1.6	-1.1	-1.1	1.2	1.4
Total sessions with >9 infusions	0.4	0.5	0.8	-0.5	-0.7	-0.7	0.9	0.5
Short access day 1 total inactive lever presses	0.7	1.3	1.5	-1.2	-1.2	-1.2	1.2	1.0
Short access day 10 total inactive lever presses	0.0	0.3	0.5	-0.6	-0.5	-0.5	0.3	0.7
Short access day 1 total infusions	0.0	0.1	0.2	0.1	-0.3	-0.3	0.4	-0.1
Short access day 10 total infusions	0.4	0.6	0.8	-0.7	-0.8	-0.9	0.9	0.7
Short access total infusions	0.8	1.2	1.4	-1.0	-1.1	-1.1	1.2	1.1
Short access day 1 locomotion	0.1	0.1	0.3	0.5	0.3	0.3	-0.1	0.1
Short access day 10 total locomotion	0.1	0.5	1.9	-0.6	-0.3	-0.3	0.3	1.4
Short access total locomotion	0.4	0.5	1.6	-0.7	-0.4	-0.5	0.5	1.3
One hour access (0.3 mA shock)	0.0	0.1	0.1	0.4	-0.1	-0.1	0.3	-0.1
Compulsive drug intake	0.1	0.1	0.2	-0.1	-0.3	-0.3	0.5	-0.2
One hour access (shock baseline)	0.1	0.3	0.6	0.8	0.5	0.5	-0.4	-0.4
Social response proportion	0.3	0.3	0.5	-0.2	-0.7	-0.7	0.6	0.3
Social responses	7.1	9.3	10.8	-2.7	-3.3	-3.3	3.2	2.7
Social time	0.2	0.4	0.5	-0.1	-0.7	-0.7	0.7	-0.4
Soleus weight	1.0	3.0	3.5	1.7	1.8	1.8	-1.9	-1.4
Bone: stiffness	14.2	25.8	29.6	5.4	5.2	5.2	-5.0	-4.5
Tibialis anterior weight	2.3	8.1	9.8	3.0	3.0	3.0	-3.1	-1.8
Time to tail flick, vehicle, before self-admin	2.2	2.8	3.4	-1.8	-1.6	-1.6	1.8	1.3
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.6	0.2	-0.1	-0.1	0.3	0.8
Time to tail flick, test, before self-admin	0.2	0.3	0.5	-0.1	-0.7	-0.7	0.5	0.4
Time to tail flick, test, after self-admin	0.8	0.9	2.2	1.5	0.6	0.6	-0.9	-0.7
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.6	0.8	0.7	0.6	-0.6	-0.5
Delta time to tail flick, test, before/after SA	0.4	0.6	1.0	1.0	0.7	0.7	-0.8	-0.6
Tibia length	5.6	15.7	17.5	3.9	4.2	4.2	-4.1	-3.4
Ambulatory time before self-admin	0.8	2.5	3.4	-1.7	-1.5	-1.5	1.4	1.8
Ambulatory time after self-admin	1.0	1.6	3.8	-1.9	-1.0	-1.0	0.9	1.0
Bone: tissue strength	0.2	0.2	0.4	0.4	0.6	0.6	-0.6	-0.1
Total heroin consumption	0.7	0.8	1.2	0.8	1.1	1.1	-0.9	-0.0
Bone: trabecular number	3.9	7.3	7.9	2.7	2.7	2.7	-2.7	-2.8
Bone: trabecular spacing	1.1	1.6	1.7	-1.3	-1.3	-1.3	1.3	1.3
Bone: trabecular thickness	0.1	0.2	0.2	-0.3	-0.5	-0.5	0.4	0.2
Bone: trabecular tissue density	0.1	0.2	0.7	-0.4	-0.3	-0.3	0.3	0.8
Water consumed over 24 hours	0.2	0.5	0.8	0.6	0.6	0.6	-0.7	-0.9
Number of responses in last shaping day	0.3	0.4	0.6	0.7	0.4	0.4	-0.8	0.7