Hub : Genes

LOC134479404

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC134479404	0.42	0.1	0.0e+00	0.38	0.38	0.37	0.38	9.4e-44	5.3e-44	2.4e-43	3.7e-44
2	pVTA	gene expression	LOC134479404	0.06	0.03	3.2e-03	0.02	0.03	0.04	0.03	4.5e-03	2.1e-03	5.8e-04	4.0e-03
3	Liver	gene expression	LOC134479404	0.04	0.03	6.4e-03	0.03	0	0.01	0.01	5.2e-04	9.2e-02	8.8e-03	7.5e-03
4	NAcc	gene expression	LOC134479404	0.02	0.02	6.0e-03	0.01	0.01	0	0	9.8e-03	2.5e-02	2.2e-01	1.0e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.9	1.5	3.1	1.3	1.2	-1.8	-0.3
Area under the delay curve	0.1	0.2	0.2	0.2	0.4	-0.5	-0.5
BMI with tail	0.7	2.4	8.5	0.3	-0.1	-0.9	-2.9
BMI without tail	1.6	4.8	6.9	2.1	1.9	-2.6	-2.0
Body weight	3.1	13.7	16.0	3.5	3.9	-3.3	-4.0
Weight adjusted by age	1.7	2.6	4.0	1.6	1.7	-2.0	-0.9
Bone surface	0.9	1.7	4.3	0.9	1.3	-2.1	0.1
Bone volume	1.6	2.9	5.1	1.5	2.3	-2.1	0.1
Breakpoint value in progressive ratio session	3.1	3.8	5.5	2.3	1.9	-1.7	-1.8
Number of licking bursts	4.2	6.8	8.8	-3.0	-2.9	2.3	2.2
Context. condit. distance diff. score	1.2	1.4	4.8	0.6	0.7	-0.2	-2.2
Locomotion velocity, session 1	0.3	0.3	0.5	0.4	0.2	-0.6	0.7
Locomotion distance, session 1	2.0	2.5	4.2	-1.9	-2.0	1.5	-0.0
Locomotion velocity, session 2	0.1	0.2	0.3	-0.3	-0.4	0.6	0.0
Locomotion distance, session 2	1.6	2.2	2.9	-1.5	-1.7	1.7	0.9
Locomotion velocity, session 3	0.9	1.0	1.7	-0.4	0.7	1.3	1.3
Locomotion distance, session 3	1.1	1.1	2.3	-0.7	0.3	1.3	1.5
Stereotopy head waving bouts, day 3	2.3	2.7	5.0	1.5	2.2	-1.7	-0.6
Stereotopy head waving duration, day 3	1.0	1.1	2.7	1.0	1.7	-0.9	-0.3
Locomotion velocity, session 7	0.7	0.7	1.8	-1.0	-0.2	1.3	0.0
Locomotion distance, session 7	0.8	1.0	1.9	-1.2	-1.4	0.8	-0.4
Stereotopy head waving bouts, day 7	2.9	3.3	6.9	1.8	2.6	-1.4	-1.0
Stereotopy head waving duration, day 7	3.6	4.4	8.8	2.3	3.0	-1.5	-1.1
Locomotion velocity, session 8	1.1	1.3	4.0	0.9	0.3	-0.6	-2.0
Locomotion distance, session 8	0.7	1.0	2.1	-0.5	-0.4	1.2	-1.4
Degree of sensitization distance	0.7	0.8	1.8	-0.2	-1.0	-0.5	-1.4
Degree of sensitization stereotypy	2.0	2.2	4.7	1.5	2.2	-1.0	-0.9
Conditioned locomotion	2.2	2.5	3.8	-1.9	-0.6	1.5	1.9
Cocaine response after cond. corrected	1.9	2.3	5.8	-1.6	-0.8	2.4	0.3
Cocaine response after cond. not corrected	1.5	1.7	4.2	-1.4	-0.6	2.1	-0.5
Cocaine response before conditioning	0.7	0.9	2.0	0.3	0.5	-1.1	-1.4
Saline control response	0.2	0.3	0.6	-0.5	-0.4	-0.5	-0.8
Bone: connectivity density	0.2	0.4	0.7	0.8	0.2	-0.6	-0.7
Bone: cortical apparent density	1.7	2.3	4.7	-1.6	-1.4	0.1	2.2
Bone: cortical area	0.5	0.8	1.6	0.2	1.3	0.6	1.1
Bone: cortical porosity	1.1	1.2	2.4	1.5	0.6	-0.8	-1.2
Bone: cortical porosity	0.8	0.8	1.6	1.3	0.6	-0.7	-1.0
Bone: cortical thickness	1.3	2.1	5.6	-1.4	-0.8	2.4	0.6
Bone: cortical thickness	5.7	6.7	11.7	-2.8	-2.4	3.4	1.2
Bone: cortical tissue density	1.7	2.3	4.6	-1.6	-1.4	0.1	2.1
Condit. Reinf. active minus inactive responses	1.5	1.6	3.3	1.8	0.8	-0.8	-1.4
Condit. Reinf. active-inactive response ratio	0.9	0.9	2.4	1.6	0.9	-0.6	-0.3
Condit. Reinf. active responses	0.8	1.0	2.0	1.4	-0.0	-0.4	-1.4
Condit. Reinf. inactive responses	0.9	1.2	2.4	-0.1	-1.6	-0.1	-1.5
Incentive salience index mean	1.3	1.6	3.6	1.9	0.6	-0.5	-1.4
Condit. Reinf. lever presses	0.7	1.0	2.6	1.6	0.4	-0.5	-1.0
Condit. Reinf. active minus inactive responses	1.1	1.4	2.3	-0.5	-1.5	-0.9	-1.4
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	-0.1	-0.8	-0.8	-0.8
Condit. Reinf. active responses	0.7	1.0	2.0	0.3	-0.4	-1.4	-1.2
Condit. Reinf. inactive responses	0.0	0.1	0.2	0.1	0.2	-0.4	-0.1
Condit. Reinf. lever presses	1.8	2.5	5.0	1.7	1.2	-2.2	-0.8
Condit. Reinf. lever reinforcers received	1.0	1.3	2.7	0.5	-0.4	-1.6	-1.5
Conditioned reinforcement - actives	0.2	0.3	0.6	0.3	-0.3	0.7	-0.8
Conditioned reinforcement - inactives	0.6	0.9	1.8	-0.8	-1.1	1.3	0.1
Conditioned locomotion	0.5	0.7	2.2	-0.3	-0.8	1.5	-0.2
Patch foraging indifference point 0 sec	1.3	2.4	7.1	1.0	0.3	-2.7	-1.3
Patch foraging indifference point AUC	0.1	0.2	0.4	0.6	0.4	-0.5	-0.2
Delay disc. indifference point, 0s delay	0.9	0.9	1.8	-0.1	-1.3	-0.9	-1.0
Delay disc. indifference point, 16s delay	0.2	0.2	0.8	0.0	0.9	-0.1	0.5
Delay disc. indifference point, 2s delay	1.1	1.3	3.0	0.9	0.4	-1.0	-1.7
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	0.1	-0.0	0.2	0.2
Delay disc. indifference point, 4s delay	0.5	0.5	1.2	-0.5	-0.5	0.4	1.1
Delay disc. indifference point, 8s delay	1.1	1.3	2.0	0.9	0.9	-1.4	-1.3
Indifference point function ln k	0.2	0.3	0.6	0.4	0.1	-0.7	-0.8
Indifference point function log k	0.2	0.3	0.6	0.4	0.1	-0.7	-0.8
Patch foraging total patch changes 0 sec	1.4	2.6	7.3	1.0	0.2	-2.7	-1.4
Patch foraging total patch changes 12 sec	1.6	2.1	3.5	1.6	1.3	-1.9	-0.9
Patch foraging total patch changes 18 sec	1.2	1.9	5.7	0.8	0.7	-2.4	-0.8
Patch foraging total patch changes 24 sec	1.5	2.5	4.5	1.4	1.5	-2.1	-1.2
Patch foraging total patch changes 6 sec	0.4	0.7	2.4	0.3	0.2	-1.5	-0.3
Patch foraging time to switch 0 sec	0.8	1.6	2.9	-0.9	0.6	1.5	1.7
Patch foraging water rate 0 sec	1.4	2.9	6.5	1.2	0.1	-1.8	-2.6
Patch foraging water rate 12 sec	0.7	1.5	3.1	1.1	-0.1	-1.2	-1.8
Patch foraging water rate 18 sec	2.6	4.1	8.9	2.3	1.0	-1.1	-3.0
Patch foraging water rate 24 sec	3.2	4.5	11.0	1.8	0.1	-2.0	-3.3
Patch foraging water rate 6 sec	3.0	4.3	6.3	2.5	1.5	-2.5	-1.7
Seeking ratio, delayed vs. immediate footshock	0.9	1.1	2.0	-1.4	-1.0	0.8	0.9
Distance traveled before self-admin	0.3	0.4	0.9	-1.0	-0.6	0.2	-0.4
Distance traveled after self-admin	0.5	0.6	1.4	0.8	1.2	-0.3	-0.5
Extensor digitorum longus weight	0.3	1.1	1.8	0.2	1.3	-0.9	-1.3
Bone: elastic displacement	1.7	1.9	2.8	-1.5	-1.5	1.7	0.7
Bone: elastic work	0.6	0.7	1.2	-0.2	-0.7	1.1	-1.1
Bone: endosteal estimation	2.2	4.7	8.8	2.0	3.0	-2.3	1.0
Bone: endosteal perimeter	1.8	3.8	8.1	1.9	2.8	-1.6	0.9
Epididymis fat weight	0.1	0.5	0.9	0.9	0.5	-0.3	-0.8
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	-0.2	-0.2	0.5	0.6
Delta time in open arm before/after self-admin	1.3	1.3	2.7	0.7	0.5	-1.3	-1.6
Diff in mean of infusions in LGA sessions	1.0	1.2	2.6	0.7	0.2	-1.6	-1.4
Delay discount exponential model param	0.1	0.1	0.2	-0.2	-0.4	0.4	0.4
Extinction: sum of active levers before priming	2.9	3.2	6.6	2.1	2.6	-1.2	-0.4
Active lever presses in extinction session 6	3.5	3.5	4.9	2.1	2.2	-2.1	-0.7
Bone: final force	1.1	1.7	3.2	1.5	1.2	-0.0	-1.8
Bone: final moment	1.2	1.9	3.3	1.6	1.2	-0.5	-1.8
Food consumed during 24 hour testing period	0.2	0.3	0.8	0.3	0.4	-0.3	-0.9
Glucose	1.1	1.8	2.9	-1.3	-1.2	1.0	1.7
Heart weight	0.9	1.3	3.4	0.9	1.0	-1.8	-0.1
Delay discount hyperbolic model param	0.1	0.2	0.3	-0.3	-0.4	0.4	0.5
Intermittent access intake day 1-15 change	0.9	1.9	4.0	-1.4	-2.0	1.3	0.2
Intermittent access intake escalation	0.9	1.9	4.0	-1.4	-2.0	1.2	0.2
Intermittent access intake escalation 2	0.9	1.0	1.8	-0.9	-0.9	1.4	0.8
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.1	-0.4	0.0	-0.3	-0.2
Intermitt. access day 15 inactive lever presses	0.2	0.3	1.0	0.4	-0.0	0.4	-1.0
Intermitt. access escalation Index	0.2	0.2	0.4	0.6	0.5	-0.2	-0.4
Intermittent access day 1 total infusions	0.2	0.4	0.6	0.3	0.7	0.6	0.8
Intermittent access day 15 total infusions	0.8	1.2	2.0	-0.8	-1.1	1.4	0.7
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.6	0.1	0.1	0.8	0.8
Intermittent access total infusions	0.3	0.3	0.5	-0.4	-0.5	0.7	0.7
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.4	0.5	0.1	0.2
Intermittent access day 15 total locomotion	0.1	0.2	0.4	-0.3	-0.7	0.6	0.0
Intermittent access total locomotion	0.1	0.1	0.4	0.2	0.1	0.6	-0.3
Intermittent access standard deviation	0.2	0.4	0.7	-0.5	-0.6	0.4	0.8
Left kidney weight	0.2	0.8	2.5	0.8	1.6	-0.0	-0.3
Right kidney weight	0.3	1.3	3.4	-0.2	1.9	0.6	1.1
Cocaine induced anxiety	0.9	1.2	4.2	-0.4	-0.6	2.0	-0.4
Post-drug Anxiety	1.2	1.3	3.6	-0.9	-0.9	1.9	0.3
Baseline Anxiety	0.4	0.4	1.1	-0.6	-0.3	-0.4	1.0
Tail length	2.0	7.9	15.6	3.0	3.9	-2.4	-1.1
Length with tail	3.7	16.1	29.2	4.5	5.4	-2.9	-2.5
Length without tail	1.7	5.3	9.5	2.6	3.1	-1.6	-1.6
Times rat made contact with spout	0.9	1.0	1.6	0.9	1.3	-1.2	-0.3
Lifetime Intake	0.2	0.2	0.5	-0.1	-0.3	0.5	0.7
Liver weight, left	1.0	1.7	3.0	1.4	1.1	-1.7	-0.8
Liver weight, right	0.3	0.5	1.3	-0.5	-0.4	0.6	1.2
Locomotor activity	3.4	5.3	8.3	2.9	1.9	-1.4	-2.7
Locomotor testing distance	1.2	2.1	3.6	1.9	1.0	-0.7	-1.8
Locomotor testing rearing	1.0	2.1	3.0	1.7	1.5	-1.4	-1.1
Locomotion in novel chamber	0.7	0.8	2.6	-0.5	-0.3	0.7	1.6
Locomotion in novel chamber post-restriction	0.9	1.5	3.1	1.8	1.6	-0.3	-0.4
Fecal boli incidents, locomotor time 1	0.4	0.6	0.9	-0.9	-0.2	0.9	-0.8
Change in fecal boli incidents, locomotor task	1.5	1.4	3.4	-0.9	-0.4	1.1	1.8
Time >=10cm from walls, locomotor time 1	1.1	1.2	2.4	0.7	1.3	0.1	-1.5
Bouts of movement, locomotor time 1	1.2	1.4	2.0	0.8	1.4	-1.4	1.0
Total resting periods, locomotor time 1	1.1	1.2	1.7	0.6	1.3	-1.2	1.2
Rest time, locomotor task time 1	0.4	0.5	1.2	-0.9	0.1	0.1	1.1
Distance moved, locomotor task time 1	0.5	0.7	1.4	1.2	0.1	-0.2	-1.2
Vertical activity count, locomotor time 1	0.2	0.6	1.1	0.1	-0.7	0.8	-1.0
Time >=10cm from walls, locomotor time 2	1.1	1.6	3.9	0.4	-0.3	1.5	-2.0
Bouts of movement, locomotor time 2	0.6	0.9	1.8	0.1	-0.5	-1.2	1.4
Total resting periods, locomotor time 2	0.6	1.1	2.7	-0.2	-0.6	-1.2	1.7
Rest time, locomotor task time 2	1.9	2.4	3.0	-1.7	-1.7	1.2	1.5
Distance moved, locomotor task time 2	1.4	1.7	2.5	1.5	1.1	-0.8	-1.6
Vertical activity count, locomotor time 2	0.2	0.3	0.8	0.2	-0.1	0.5	-0.9
Light reinforcement 1	3.3	8.0	12.2	3.5	2.4	-1.8	-3.3
Light reinforcement 2	0.4	0.7	1.6	1.0	0.1	0.1	-1.3
Bone: marrow area	2.3	5.0	9.3	2.0	3.0	-2.4	1.0
Bone: maximum diameter	1.1	2.0	4.2	0.7	2.1	-0.7	1.7
Bone: maximum force	0.9	1.6	4.3	1.3	2.1	0.5	-0.6
Bone: maximum moment	0.9	1.6	4.2	1.3	2.1	0.1	-0.5
Mean time between licks in bursts	1.6	3.8	4.9	-1.9	-1.5	2.2	2.2
Mean num. licks in bursts	5.1	8.0	10.7	3.1	3.3	-2.7	-2.1
Cd content in liver	0.2	0.2	0.7	0.3	0.3	0.3	-0.8
Co content in liver	2.9	3.3	5.4	2.2	2.3	-1.7	0.0
Cu content in liver	0.3	0.4	0.9	-0.1	-0.7	0.1	-1.0
Fe content in liver	0.8	1.0	2.5	-0.6	-0.1	-1.0	1.6
K content in liver	0.3	0.3	0.8	0.9	0.4	-0.4	0.2
Mg content in liver	0.5	0.5	1.1	0.4	-0.1	-0.8	1.1
Mn content in liver	1.2	1.3	1.6	1.3	1.0	-1.1	1.2
Na content in liver	0.7	0.7	2.1	0.4	0.8	-1.5	-0.2
Rb content in liver	0.2	0.3	0.4	-0.4	-0.5	-0.5	0.6
Se content in liver	0.2	0.2	0.3	-0.1	-0.6	-0.4	-0.5
Sr content in liver	0.2	0.2	0.4	-0.2	0.0	0.5	-0.6
Zn content in liver	0.5	0.5	1.9	-0.1	-1.4	-0.2	0.5
Bone: minimum diameter	2.2	4.1	8.1	1.6	2.8	-1.5	1.9
Time in familiar zone, hab. session 1	0.8	0.8	2.8	-0.4	-0.5	-0.2	1.7
Time in novel zone, hab. session 1	1.0	1.0	2.4	0.8	1.0	0.1	-1.5
Total zone transitions, hab. session 1	0.7	1.0	2.0	-1.4	-0.7	1.2	-0.0
Total locomotion distance, hab. session 1	2.4	3.4	6.3	-2.5	-1.6	2.2	0.4
Locomotion velocity, hab. session 1	2.3	3.2	5.8	-2.4	-1.7	2.0	0.3
Time in familiar zone, hab. session 2	1.0	1.0	2.9	0.8	0.8	-1.7	-0.3
Time in novel zone, hab. session 2	0.9	0.9	2.2	-0.7	-0.8	1.5	-0.6
Total zone transitions, hab. session 2	0.4	0.5	1.6	-0.5	-0.4	-0.0	-1.3
Total locomotion distance, hab. session 2	1.0	1.4	2.1	-1.4	-1.3	0.9	-1.0
Locomotion velocity, hab. session 2	0.8	1.1	1.7	-1.3	-1.1	1.0	-0.8
Novel to familiar place preference ratio	1.1	1.2	3.0	-0.8	0.5	1.7	0.9
Novelty place preference	0.9	1.0	1.9	-0.5	1.0	1.4	0.9
Time in novel zone, NPP test	0.8	0.8	1.8	-0.6	0.8	1.3	0.7
Total zone transitions, NPP test	0.6	0.8	3.1	-0.1	-0.2	-0.4	-1.7
Total locomotion distance, NPP test	0.6	0.8	2.8	-0.3	0.2	0.4	-1.7
Locomotion velocity, NPP test	0.4	0.6	1.7	-0.2	0.4	0.7	-1.3
Intraocular pressure	1.6	2.4	3.0	-1.4	-1.5	1.7	-1.5
Delta distance traveled before/after self-admin	2.3	2.4	4.5	2.1	1.6	-1.4	-0.9
Delta ambulatory time before/after self-admin	1.6	2.0	3.7	1.9	1.5	-1.2	-0.8
Parametrial fat weight	0.1	0.2	0.7	0.3	0.8	0.0	0.4
Pavlov. Cond. lever latency	1.1	1.4	2.9	-1.5	-0.3	1.7	0.7
Pavlov. Cond. magazine entry latency	1.9	2.4	3.6	1.7	1.5	-1.9	-1.0
Pavlov. Cond. change in total contacts	4.7	5.0	7.6	2.6	1.7	-2.8	-1.6
Pavlov. Cond. index score	2.2	2.7	4.3	2.1	1.3	-2.0	-1.0
Pavlov. Cond. latency score	1.8	2.3	3.9	2.0	1.2	-1.8	-0.8
Pavlov. Cond. lever contacts	1.6	2.0	3.5	1.7	0.7	-1.9	-0.9
Pavlov. Cond. magazine entry number	2.6	3.3	5.6	-1.9	-1.2	2.4	1.6
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.1	-0.5	-1.0	0.3	-0.9
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.3	3.8	1.8	1.1	-1.9	-1.0
Pavlov. Cond. response bias	3.7	4.6	6.2	2.4	1.4	-2.5	-2.1
Pavlov. Cond. lever latency	1.8	2.5	4.9	-1.8	-1.0	2.2	1.0
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.8	0.1	-0.9	-0.8
Pavlov. Cond. change in total contacts	2.3	3.7	7.9	2.1	1.1	-2.8	-1.1
Pavlov. Cond. index score	1.3	1.7	3.6	1.4	0.4	-1.9	-1.0
Pavlov. Cond. latency score	1.1	1.5	2.9	1.4	0.5	-1.7	-0.9
Pavlov. Cond. lever contacts	1.9	2.6	4.8	1.9	1.1	-2.2	-0.9
Pavlov. Cond. magazine entry number	0.8	1.0	1.4	-1.2	0.3	1.0	1.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.1	-0.3	0.2	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	3.6	1.4	0.3	-1.9	-0.9
Pavlov. Cond. response bias	1.7	2.3	4.3	1.8	0.8	-2.1	-1.0
Time in closed arm before self-admin	0.3	0.4	0.6	0.6	0.2	-0.8	-0.7
Time in closed arm after self-admin	0.1	0.1	0.2	0.2	-0.2	-0.2	0.5
Time in open arm before self-admin	0.9	1.0	2.2	-0.6	0.0	1.5	1.2
Time in open arm after self-admin	0.7	0.8	1.2	0.7	1.1	-1.1	-0.5
Bone: periosteal estimation	1.4	2.9	6.7	1.3	2.6	-1.3	1.2
Bone: periosteal perimeter	2.5	4.4	9.4	2.2	3.1	-1.7	0.5
Bone: post-yield work	0.8	1.2	2.1	-0.8	1.5	0.6	1.3
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	-0.3	0.1	0.1	0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.3	0.1	0.0	0.4
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.5	0.3	0.4	-0.7	-0.2
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	-0.1	-0.3	0.5	-0.7
Progressive ratio test 2 breakpoint	0.2	0.2	0.7	-0.1	-0.3	0.4	-0.8
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.9	-0.4	-0.3	0.9	0.1
Incentive Sensitization - Responses	0.5	0.7	2.3	-0.0	-0.4	0.6	-1.5
Incentive Sensitization - Breakpoint	0.6	0.8	2.9	0.1	-0.4	0.5	-1.7
Sum of active levers in priming session hrs 5-6	4.1	3.8	5.6	2.4	2.4	-1.6	-1.1
Progressive ratio	0.3	0.5	0.9	0.7	0.9	-0.6	-0.2
Food seeking constrained by brief footshock	0.2	0.2	0.7	-0.3	-0.3	0.2	-0.8
Seeking ratio, punishment vs. effort	0.1	0.2	0.2	-0.4	-0.5	0.4	-0.2
Retroperitoneal fat weight	0.4	1.7	6.0	0.7	-0.5	-0.3	-2.4
Reaction time number correct	0.8	1.6	3.3	-0.6	-1.1	1.2	-1.8
Reaction time mean minus median	0.4	1.0	1.6	-1.3	-1.2	0.0	1.1
Reaction time mean minus median AUC	0.3	0.7	1.4	-1.1	-1.2	0.0	0.7
Reaction time num false alarms	0.3	0.4	1.0	0.2	-0.7	0.4	-1.0
Reaction time num false alarms AUC	0.4	0.7	2.0	0.2	-0.6	0.3	-1.4
Reaction time trials correct on left	0.8	1.6	3.3	-0.6	-1.1	1.2	-1.8
Reaction time trials on left	0.9	1.6	2.9	-0.7	-1.3	1.2	-1.7
Reaction time mean	1.1	1.7	3.5	-1.2	-0.9	-1.1	1.9
Reaction time mean AUC	1.1	1.8	3.2	-1.4	-1.0	-1.0	1.8
Median of all reaction times	1.1	1.6	3.1	-1.0	-0.7	-1.4	1.7
Reaction time omissions	2.5	3.6	6.5	-2.5	-2.4	-0.4	1.4
Reaction time false alarm rate	0.1	0.2	0.3	0.6	-0.0	-0.4	-0.5
Reaction time premature initiation rate	1.6	2.2	4.6	1.5	2.2	-0.8	-1.1
Reaction time premature initiations	0.9	1.7	4.0	1.0	1.3	-0.1	-2.0
Std. dev. reaction times	1.1	2.1	3.1	-1.7	-1.8	-0.1	1.5
Reaction time trials completed	0.9	1.6	2.9	-0.7	-1.3	1.2	-1.7
Reaction time trials AUC	1.0	1.9	3.2	-0.8	-1.5	1.2	-1.8
Run reversals in cocaine runway, females	0.6	0.6	1.0	1.0	0.6	-0.9	0.4
Run reversals in cocaine runway, males	0.2	0.2	0.6	0.2	-0.8	-0.4	0.3
Latency to leave start box in cocaine runway	1.0	1.1	1.6	-1.2	-1.1	-1.3	0.3
Latency to leave start box in cocaine runway, F	0.4	0.4	0.6	-0.7	-0.6	-0.8	0.4
Latency to leave start box in cocaine runway, M	0.6	0.6	1.3	-1.1	-0.8	-0.5	0.4
Std. dev. time between licks in bursts	1.0	1.4	3.9	-1.0	-0.3	0.9	2.0
Total sessions with >9 infusions	0.6	0.7	1.1	1.1	0.9	-0.9	0.3
Short access day 1 total inactive lever presses	0.4	0.5	0.8	0.9	0.8	-0.7	-0.2
Short access day 10 total inactive lever presses	0.2	0.5	1.1	-0.1	-0.2	0.9	-1.0
Short access day 1 total infusions	1.1	1.4	3.1	1.7	1.4	-0.8	0.1
Short access day 10 total infusions	0.4	0.5	1.7	-0.4	0.1	0.2	1.3
Short access total infusions	0.3	0.4	0.7	0.7	0.6	-0.1	0.9
Short access day 1 locomotion	0.8	1.0	1.6	1.3	1.3	-0.8	-0.2
Short access day 10 total locomotion	0.9	1.7	3.8	1.5	2.0	-0.5	0.6
Short access total locomotion	1.5	1.8	3.1	1.8	1.7	-1.0	0.3
One hour access (0.3 mA shock)	0.9	1.0	2.3	1.5	0.6	-0.3	-1.2
Compulsive drug intake	1.5	1.8	2.6	1.6	1.6	-1.3	-0.8
One hour access (shock baseline)	0.1	0.2	0.5	0.1	-0.4	0.7	0.1
Social response proportion	0.1	0.1	0.5	-0.1	0.0	-0.1	0.7
Social responses	0.4	0.5	1.1	0.2	-0.5	-1.0	-0.8
Social time	4.1	5.5	8.9	-2.7	-1.8	1.8	3.0
Soleus weight	2.2	6.4	11.4	2.8	3.4	-1.8	-1.8
Bone: stiffness	0.6	0.9	2.5	0.6	1.6	0.6	0.6
Tibialis anterior weight	4.8	16.3	22.1	4.1	3.6	-3.6	-4.7
Time to tail flick, vehicle, before self-admin	2.2	2.3	3.2	-1.4	-1.6	1.3	1.8
Time to tail flick, vehicle, after self-admin	1.0	1.3	2.9	-0.5	-1.7	-0.0	-1.5
Time to tail flick, test, before self-admin	2.4	2.5	3.9	-1.9	-1.5	2.0	0.2
Time to tail flick, test, after self-admin	3.8	4.0	5.2	-2.1	-2.3	2.2	1.1
Delta time to tail flick, vehicle, before/after SA	1.6	1.5	4.9	-0.1	-0.9	-0.6	-2.2
Delta time to tail flick, test, before/after SA	0.3	0.3	0.4	-0.3	-0.7	0.5	0.7
Tibia length	0.2	0.4	1.0	-0.1	0.8	1.0	-0.4
Ambulatory time before self-admin	0.3	0.4	1.1	-1.0	-0.7	0.1	-0.2
Ambulatory time after self-admin	1.3	1.5	2.0	1.2	1.4	-0.8	-1.3
Bone: tissue strength	0.9	1.0	2.0	-0.9	-1.4	-0.1	-1.0
Total heroin consumption	2.9	3.4	5.5	2.0	2.3	-1.6	-1.3
Bone: trabecular number	0.2	0.4	0.8	0.4	0.1	-0.9	0.8
Bone: trabecular spacing	0.6	0.8	2.8	0.4	0.5	1.7	-0.2
Bone: trabecular thickness	0.7	0.9	2.0	0.5	1.2	-1.4	-0.0
Bone: trabecular tissue density	0.9	1.3	2.5	0.0	1.0	-1.3	1.6
Water consumed over 24 hours	0.9	1.3	3.2	0.6	-0.1	-1.2	-1.8
Number of responses in last shaping day	0.9	1.0	1.5	1.1	1.2	-1.1	-0.4