LOC134479109

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC134479109	0.02	0.02	8.6e-04	0.01	0.02	0.01	0.02	1.7e-03	6.7e-04	4.0e-03	8.8e-04
2	Adipose	gene expression	LOC134479109	0.08	0.06	3.9e-10	0.07	0.08	0.07	0.07	1.3e-08	2.7e-09	1.9e-08	2.2e-08
3	Brain	gene expression	LOC134479109	0.18	0.19	2.6e-07	0.06	0.06	0.06	0.06	1.4e-06	1.5e-06	2.5e-06	1.5e-06
4	Brain	isoform ratio	XM_063262601.1	0.04	0.04	3.8e-03	0.03	0.02	0.01	0.02	1.2e-03	9.0e-03	1.3e-02	2.5e-03
5	PL	gene expression	LOC134479109	0.04	0.03	6.0e-06	0.06	0.05	0.06	0.06	4.2e-07	4.2e-06	2.8e-07	4.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	4.8	8.3	8.7	2.9	2.9	2.9	-2.7	2.9
Area under the delay curve	1.7	2.0	2.2	1.5	1.4	1.3	-1.4	1.4
BMI with tail	0.2	0.6	1.3	-0.7	-0.7	-0.6	0.8	-1.1
BMI without tail	0.3	0.9	1.2	-1.0	-1.0	-1.0	0.5	-1.1
Body weight	1.3	5.5	7.1	-2.5	-2.6	-2.7	1.8	-2.1
Weight adjusted by age	0.0	0.1	0.1	-0.3	-0.3	-0.2	0.2	0.2
Bone surface	1.8	3.4	4.1	2.0	1.9	1.6	-2.0	1.6
Bone volume	2.4	4.4	4.7	2.1	2.1	1.9	-2.1	2.2
Breakpoint value in progressive ratio session	0.7	0.9	1.8	0.9	0.9	0.9	-1.3	0.5
Number of licking bursts	0.2	0.4	0.7	0.6	0.5	0.5	-0.7	0.8
Context. condit. distance diff. score	0.1	0.2	0.3	-0.3	-0.3	-0.5	0.4	-0.3
Locomotion velocity, session 1	0.3	0.3	1.4	-0.2	-0.2	-0.2	0.1	-1.2
Locomotion distance, session 1	1.7	2.1	2.7	1.6	1.7	1.6	-1.4	0.6
Locomotion velocity, session 2	0.1	0.2	0.3	-0.3	-0.3	-0.6	-0.0	-0.5
Locomotion distance, session 2	0.0	0.1	0.2	0.1	0.1	0.0	-0.5	-0.3
Locomotion velocity, session 3	0.7	0.9	1.9	0.9	0.8	0.7	-1.4	0.7
Locomotion distance, session 3	1.6	1.7	3.2	1.2	1.2	1.1	-1.8	1.2
Stereotopy head waving bouts, day 3	1.1	1.2	1.9	1.1	1.1	1.0	-1.0	1.4
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.1	0.1	0.0	-0.1	0.3
Locomotion velocity, session 7	1.1	1.2	3.1	1.1	1.0	0.8	-1.8	0.5
Locomotion distance, session 7	0.1	0.1	0.1	-0.1	-0.2	-0.4	-0.4	-0.0
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.3	0.3	0.5	-0.5	0.1
Stereotopy head waving duration, day 7	0.8	0.9	1.5	0.9	0.9	1.1	-1.2	0.6
Locomotion velocity, session 8	0.1	0.1	0.4	0.1	0.0	-0.0	-0.7	0.3
Locomotion distance, session 8	0.1	0.2	0.3	0.4	0.4	0.1	-0.6	-0.2
Degree of sensitization distance	1.7	1.7	2.2	-1.3	-1.3	-1.3	1.5	-1.2
Degree of sensitization stereotypy	0.1	0.1	0.2	0.0	0.0	0.3	-0.4	-0.5
Conditioned locomotion	1.8	2.1	2.8	1.7	1.7	1.6	-1.2	0.9
Cocaine response after cond. corrected	2.6	3.1	4.9	1.6	1.6	1.6	-1.7	2.2
Cocaine response after cond. not corrected	3.2	3.7	4.9	1.9	1.9	1.9	-1.6	2.2
Cocaine response before conditioning	0.4	0.5	0.7	0.8	0.9	0.8	-0.4	0.2
Saline control response	1.2	1.6	2.7	1.2	1.2	1.3	-1.6	0.8
Bone: connectivity density	4.6	7.1	7.5	2.7	2.7	2.7	-2.5	2.7
Bone: cortical apparent density	1.0	1.4	3.4	1.0	1.0	1.1	-0.5	1.8
Bone: cortical area	0.6	1.0	1.4	1.1	1.1	1.2	-0.9	0.6
Bone: cortical porosity	0.6	0.7	0.9	0.9	0.9	0.9	-0.4	0.8
Bone: cortical porosity	0.8	0.9	1.1	1.0	1.0	1.1	-0.6	1.0
Bone: cortical thickness	0.1	0.1	0.2	0.1	0.1	0.5	0.4	-0.2
Bone: cortical thickness	0.9	1.1	1.4	1.1	1.2	1.2	-0.4	1.1
Bone: cortical tissue density	0.8	1.0	2.9	0.8	0.8	1.0	-0.3	1.7
Condit. Reinf. active minus inactive responses	0.1	0.2	0.2	-0.5	-0.5	-0.5	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.2	-0.3	-0.4	-0.5	-0.2
Condit. Reinf. active responses	0.5	0.6	0.8	0.8	0.8	0.7	-0.6	0.9
Condit. Reinf. inactive responses	1.1	1.4	1.7	1.2	1.3	1.3	-0.5	1.3
Incentive salience index mean	0.5	0.7	1.3	0.6	0.6	0.5	-1.0	1.1
Condit. Reinf. lever presses	2.2	3.1	4.7	1.6	1.5	1.4	-2.2	2.0
Condit. Reinf. active minus inactive responses	1.9	2.4	3.3	1.8	1.8	1.7	-0.8	1.5
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.6	0.8	0.8	0.5	-0.5	0.4
Condit. Reinf. active responses	1.5	2.1	2.8	1.6	1.7	1.7	-0.4	1.4
Condit. Reinf. inactive responses	1.1	1.4	2.2	1.2	1.3	1.5	-0.1	1.3
Condit. Reinf. lever presses	1.2	1.6	2.5	1.3	1.3	1.3	-0.4	1.6
Condit. Reinf. lever reinforcers received	1.3	1.9	2.5	1.5	1.5	1.6	-0.2	1.5
Conditioned reinforcement - actives	0.4	0.6	2.2	0.5	0.4	0.1	-0.6	1.5
Conditioned reinforcement - inactives	2.2	3.3	4.4	1.6	1.7	1.6	-2.0	2.1
Conditioned locomotion	0.2	0.3	0.6	-0.6	-0.6	-0.8	-0.1	0.5
Patch foraging indifference point 0 sec	0.1	0.2	0.4	-0.4	-0.5	-0.6	-0.4	-0.2
Patch foraging indifference point AUC	1.2	1.7	2.6	1.1	1.1	1.4	-1.2	1.6
Delay disc. indifference point, 0s delay	0.8	0.9	2.1	-0.9	-0.8	-0.5	1.5	-0.8
Delay disc. indifference point, 16s delay	1.7	1.8	2.4	1.4	1.3	1.2	-1.6	1.3
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	-0.0	-0.0	0.0	0.3	0.2
Delay disc. indifference point, 24s delay	5.0	5.6	7.8	2.5	2.4	2.1	-2.8	1.8
Delay disc. indifference point, 4s delay	0.2	0.2	0.7	0.4	0.4	0.3	-0.3	0.8
Delay disc. indifference point, 8s delay	1.3	1.6	2.3	1.3	1.2	1.1	-1.5	1.1
Indifference point function ln k	0.1	0.3	1.1	-0.1	-0.1	-0.2	0.3	-1.1
Indifference point function log k	0.1	0.3	1.1	-0.1	-0.1	-0.2	0.3	-1.1
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.4	-0.4	-0.6	-0.5	-0.3
Patch foraging total patch changes 12 sec	0.6	0.7	1.0	-1.0	-1.0	-1.0	0.3	-0.8
Patch foraging total patch changes 18 sec	0.1	0.2	0.6	-0.1	-0.1	-0.0	-0.7	0.8
Patch foraging total patch changes 24 sec	1.0	1.8	2.8	-1.5	-1.5	-1.7	0.7	-1.0
Patch foraging total patch changes 6 sec	0.1	0.1	0.4	-0.1	-0.1	-0.2	-0.6	-0.4
Patch foraging time to switch 0 sec	0.1	0.2	0.3	0.5	0.5	0.4	-0.6	0.1
Patch foraging water rate 0 sec	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.5	0.3
Patch foraging water rate 12 sec	1.8	3.8	4.9	-1.8	-1.7	-1.9	2.1	-2.2
Patch foraging water rate 18 sec	1.1	1.6	3.7	-0.9	-0.9	-1.1	1.3	-1.9
Patch foraging water rate 24 sec	2.6	3.7	5.6	-1.9	-1.9	-1.6	2.4	-1.8
Patch foraging water rate 6 sec	1.7	2.5	3.5	-1.5	-1.5	-1.5	1.5	-1.9
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.6	-0.8	-0.7	-0.6	0.6	-0.6
Distance traveled before self-admin	0.1	0.1	0.2	0.0	-0.0	-0.3	0.0	-0.5
Distance traveled after self-admin	0.9	1.1	1.5	-1.2	-1.2	-1.1	0.9	-0.7
Extensor digitorum longus weight	4.6	17.9	21.2	4.5	4.5	4.6	-4.1	3.2
Bone: elastic displacement	0.4	0.5	0.8	0.7	0.8	0.9	0.2	0.7
Bone: elastic work	0.8	1.0	1.6	1.0	1.0	1.1	-0.4	1.3
Bone: endosteal estimation	0.4	1.0	2.2	1.0	1.0	0.4	-1.5	0.6
Bone: endosteal perimeter	0.3	0.6	1.5	0.7	0.7	0.4	-1.2	0.5
Epididymis fat weight	14.2	48.5	54.9	-7.4	-7.4	-7.2	6.4	-6.3
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.0	0.3
Delta time in open arm before/after self-admin	0.9	0.9	1.5	0.9	0.9	1.2	-0.8	1.0
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.0	0.1	0.3	-0.4	0.3
Delay discount exponential model param	2.7	3.0	3.2	-1.8	-1.8	-1.6	1.8	-1.8
Extinction: sum of active levers before priming	1.2	1.3	1.8	1.2	1.2	1.1	-1.4	0.9
Active lever presses in extinction session 6	0.1	0.1	0.5	-0.1	-0.1	0.1	-0.2	-0.7
Bone: final force	0.2	0.3	0.6	0.5	0.5	0.4	-0.8	0.5
Bone: final moment	0.2	0.3	0.7	0.6	0.6	0.4	-0.8	0.4
Food consumed during 24 hour testing period	0.1	0.1	0.1	0.3	0.3	0.3	0.0	-0.3
Glucose	0.4	0.6	0.8	-0.9	-0.9	-0.8	0.7	-0.4
Heart weight	2.4	3.7	4.7	-2.1	-2.1	-2.2	1.8	-1.4
Delay discount hyperbolic model param	1.8	2.0	2.4	-1.5	-1.4	-1.3	1.4	-1.5
Intermittent access intake day 1-15 change	0.3	0.7	1.3	-0.6	-0.6	-0.8	1.1	-0.8
Intermittent access intake escalation	0.4	0.9	1.5	-0.8	-0.8	-1.0	1.2	-0.9
Intermittent access intake escalation 2	0.9	1.0	1.8	-0.9	-0.9	-1.0	1.3	-0.9
Intermitt. access day 1 inactive lever presses	0.3	1.2	3.7	0.8	0.8	0.5	-1.0	1.9
Intermitt. access day 15 inactive lever presses	1.6	3.3	3.5	1.8	1.8	1.7	-1.8	1.9
Intermitt. access escalation Index	0.3	0.4	0.7	-0.8	-0.8	-0.7	0.6	-0.2
Intermittent access day 1 total infusions	3.0	4.9	6.4	2.0	2.0	2.0	-2.5	2.4
Intermittent access day 15 total infusions	0.7	1.0	1.9	0.9	0.9	0.7	-0.9	1.4
Intermittent access terminal intake (last 3 days)	1.4	1.8	3.2	1.2	1.3	1.2	-1.1	1.8
Intermittent access total infusions	1.6	1.9	3.8	1.2	1.2	1.1	-1.2	1.9
Intermittent access day 1 locomotion	2.0	2.6	3.6	1.4	1.5	1.6	-1.9	1.5
Intermittent access day 15 total locomotion	0.1	0.1	0.6	0.0	0.0	-0.2	-0.1	0.8
Intermittent access total locomotion	0.1	0.2	0.6	0.1	0.2	0.1	-0.4	0.8
Intermittent access standard deviation	0.2	0.4	0.4	0.6	0.7	0.6	-0.5	0.6
Left kidney weight	0.0	0.1	0.6	0.2	0.1	-0.0	0.1	0.8
Right kidney weight	0.1	0.3	0.5	-0.5	-0.5	-0.7	0.5	0.1
Cocaine induced anxiety	0.1	0.2	0.3	0.4	0.4	0.5	-0.5	-0.3
Post-drug Anxiety	1.1	1.1	1.3	-1.1	-1.1	-1.1	0.8	-1.1
Baseline Anxiety	1.5	1.8	2.6	-1.5	-1.5	-1.6	1.2	-0.4
Tail length	0.4	1.5	2.7	-1.3	-1.4	-1.7	0.7	-0.5
Length with tail	1.5	6.6	9.6	-2.8	-2.9	-3.1	2.2	-1.6
Length without tail	0.8	2.4	2.9	-1.7	-1.7	-1.7	1.7	-0.9
Times rat made contact with spout	4.2	4.8	7.3	2.0	1.9	1.6	-2.7	2.5
Lifetime Intake	1.2	1.5	2.7	1.0	1.1	1.0	-1.2	1.6
Liver weight, left	2.5	4.2	6.1	-2.3	-2.4	-2.5	1.0	-1.7
Liver weight, right	8.3	14.6	16.8	-4.1	-4.1	-4.0	3.7	-3.1
Locomotor activity	0.1	0.1	0.3	0.4	0.4	0.2	-0.6	-0.1
Locomotor testing distance	1.0	1.7	2.1	1.4	1.4	1.3	-1.4	1.1
Locomotor testing rearing	0.5	0.9	1.4	0.9	0.9	1.1	-0.6	1.2
Locomotion in novel chamber	0.8	1.0	1.2	-1.1	-1.1	-1.0	0.7	-1.1
Locomotion in novel chamber post-restriction	1.7	2.8	3.5	-1.9	-1.8	-1.7	1.6	-1.3
Fecal boli incidents, locomotor time 1	0.9	1.3	3.1	0.9	0.9	1.0	-0.8	1.8
Change in fecal boli incidents, locomotor task	3.9	3.9	5.2	-2.1	-2.1	-1.9	2.3	-1.2
Time >=10cm from walls, locomotor time 1	0.2	0.3	0.9	-0.0	0.1	0.2	0.9	0.6
Bouts of movement, locomotor time 1	3.4	3.8	4.4	2.1	2.1	1.9	-1.7	2.0
Total resting periods, locomotor time 1	3.3	3.7	4.2	2.1	2.1	1.8	-1.8	1.8
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.2	-0.2	-0.4	-0.3	-0.2
Distance moved, locomotor task time 1	0.3	0.5	0.7	-0.8	-0.8	-0.6	0.7	-0.6
Vertical activity count, locomotor time 1	0.2	0.4	0.7	-0.7	-0.7	-0.7	0.8	-0.4
Time >=10cm from walls, locomotor time 2	0.2	0.4	1.7	-0.2	-0.2	-0.0	1.3	-0.2
Bouts of movement, locomotor time 2	0.2	0.3	0.9	-0.3	-0.4	-0.6	1.0	-0.4
Total resting periods, locomotor time 2	0.1	0.1	0.4	-0.1	-0.1	-0.4	0.7	-0.1
Rest time, locomotor task time 2	2.0	2.5	4.6	1.4	1.4	1.4	-1.4	2.1
Distance moved, locomotor task time 2	1.8	2.1	5.5	-1.2	-1.2	-1.0	1.1	-2.3
Vertical activity count, locomotor time 2	1.7	2.4	3.7	-1.4	-1.4	-1.4	1.6	-1.9
Light reinforcement 1	3.4	8.4	9.5	2.9	2.9	3.1	-2.9	2.6
Light reinforcement 2	2.6	4.0	4.7	2.1	2.1	2.0	-2.2	1.5
Bone: marrow area	0.5	1.0	2.3	1.1	1.0	0.4	-1.5	0.6
Bone: maximum diameter	1.3	2.4	3.2	1.7	1.6	1.6	-1.8	1.1
Bone: maximum force	0.1	0.3	0.4	0.5	0.5	0.5	-0.6	0.3
Bone: maximum moment	0.2	0.3	0.5	0.6	0.6	0.5	-0.7	0.2
Mean time between licks in bursts	1.7	4.2	4.6	-2.1	-2.1	-2.0	2.1	-2.0
Mean num. licks in bursts	0.2	0.3	0.5	0.5	0.5	0.3	-0.7	0.6
Cd content in liver	0.1	0.1	0.2	0.3	0.3	0.4	-0.3	0.5
Co content in liver	7.8	9.0	10.2	3.1	3.1	3.2	-2.8	2.8
Cu content in liver	0.6	0.8	1.4	0.8	0.7	0.6	-1.2	1.0
Fe content in liver	0.8	1.0	2.9	0.8	0.7	0.6	-0.6	1.7
K content in liver	0.4	0.4	1.5	0.5	0.4	-0.1	-1.2	0.1
Mg content in liver	1.7	1.8	5.7	1.1	0.9	0.3	-2.4	1.0
Mn content in liver	0.1	0.1	0.2	0.1	0.1	0.1	-0.3	-0.4
Na content in liver	0.4	0.4	1.2	0.6	0.5	0.1	-1.1	0.5
Rb content in liver	0.7	0.8	2.9	0.6	0.5	0.1	-1.7	0.6
Se content in liver	0.2	0.2	0.3	-0.5	-0.5	-0.6	0.3	0.2
Sr content in liver	0.4	0.3	0.9	-0.4	-0.4	-0.6	0.3	-0.9
Zn content in liver	0.2	0.2	0.3	-0.5	-0.5	-0.6	0.2	0.5
Bone: minimum diameter	0.1	0.2	0.8	0.1	0.0	-0.1	-0.9	-0.3
Time in familiar zone, hab. session 1	0.3	0.3	0.5	-0.6	-0.7	-0.7	-0.0	0.2
Time in novel zone, hab. session 1	1.1	1.1	2.2	-0.9	-0.9	-0.7	1.1	-1.5
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.3	0.4	0.4	-0.1	-0.4
Total locomotion distance, hab. session 1	0.0	0.1	0.3	0.1	0.1	0.1	0.1	-0.5
Locomotion velocity, hab. session 1	0.4	0.6	0.9	0.9	1.0	1.0	-0.5	0.2
Time in familiar zone, hab. session 2	0.2	0.2	0.9	0.2	0.1	0.0	-0.9	0.1
Time in novel zone, hab. session 2	0.7	0.7	1.5	-0.7	-0.7	-0.6	1.2	-0.9
Total zone transitions, hab. session 2	0.2	0.3	0.5	0.5	0.5	0.3	-0.7	-0.6
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.5	0.4	0.3	-0.4	0.1
Locomotion velocity, hab. session 2	0.3	0.4	0.5	0.7	0.7	0.6	-0.7	0.4
Novel to familiar place preference ratio	1.6	1.8	3.4	-1.0	-0.9	-0.7	1.8	-1.8
Novelty place preference	2.3	2.5	4.7	-1.2	-1.2	-1.0	1.9	-2.2
Time in novel zone, NPP test	2.6	2.7	5.3	-1.3	-1.3	-1.1	1.9	-2.3
Total zone transitions, NPP test	1.4	2.1	2.8	1.6	1.6	1.4	-1.7	0.9
Total locomotion distance, NPP test	1.0	1.4	2.0	1.4	1.4	1.2	-0.9	0.9
Locomotion velocity, NPP test	2.4	3.4	4.4	2.1	2.1	1.9	-1.6	1.5
Intraocular pressure	2.7	4.0	4.4	-2.0	-2.1	-2.1	1.9	-1.9
Delta distance traveled before/after self-admin	1.6	1.7	2.4	-1.5	-1.5	-1.2	1.4	-0.5
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	-0.6	-0.5	-0.2	0.6	0.3
Parametrial fat weight	7.5	17.7	21.7	-4.7	-4.6	-4.2	3.5	-3.9
Pavlov. Cond. lever latency	2.6	3.3	4.5	-1.7	-1.6	-1.4	2.1	-2.1
Pavlov. Cond. magazine entry latency	0.2	0.3	0.8	0.4	0.4	0.1	-0.9	0.5
Pavlov. Cond. change in total contacts	0.4	0.4	0.9	0.4	0.3	-0.1	-1.0	0.9
Pavlov. Cond. index score	1.1	1.4	2.4	1.1	1.0	0.7	-1.5	1.3
Pavlov. Cond. latency score	1.0	1.2	2.1	1.1	1.0	0.6	-1.4	1.3
Pavlov. Cond. lever contacts	2.0	2.4	3.6	1.4	1.3	1.0	-1.9	1.8
Pavlov. Cond. magazine entry number	0.4	0.4	0.8	-0.7	-0.6	-0.4	0.9	-0.7
Pavlov. Cond. intertrial magazine entries	1.7	2.0	2.8	1.3	1.3	1.6	-1.0	1.7
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.5	3.5	1.5	1.4	1.1	-1.9	1.8
Pavlov. Cond. response bias	1.4	1.8	3.0	1.3	1.3	0.9	-1.7	1.3
Pavlov. Cond. lever latency	1.0	1.4	2.0	-1.2	-1.2	-1.1	0.8	-1.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.3	0.3	0.4	0.0	0.6
Pavlov. Cond. change in total contacts	0.4	0.6	1.5	0.7	0.7	0.6	-0.1	1.2
Pavlov. Cond. index score	0.5	0.7	1.4	0.8	0.8	0.8	-0.1	1.2
Pavlov. Cond. latency score	0.5	0.6	1.2	0.8	0.8	0.8	-0.2	1.1
Pavlov. Cond. lever contacts	0.6	0.9	1.5	1.0	1.0	0.9	-0.5	1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.2	-0.3	-0.3	0.0	-0.5
Pavlov. Cond. intertrial magazine entries	2.4	3.6	4.2	-2.0	-1.9	-1.8	2.0	-1.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.7	0.5	0.5	0.5	0.1	0.9
Pavlov. Cond. response bias	1.2	1.6	2.4	1.3	1.3	1.3	-0.7	1.6
Time in closed arm before self-admin	1.5	1.9	4.2	-1.3	-1.3	-0.9	2.1	-1.0
Time in closed arm after self-admin	1.8	1.9	3.9	-1.5	-1.4	-1.1	2.0	-0.6
Time in open arm before self-admin	0.4	0.4	1.6	0.6	0.5	0.2	-1.3	-0.1
Time in open arm after self-admin	2.8	3.1	5.2	1.7	1.7	1.6	-2.3	1.3
Bone: periosteal estimation	0.8	1.7	2.7	1.4	1.4	1.1	-1.7	0.8
Bone: periosteal perimeter	0.4	0.7	1.4	0.9	0.9	0.7	-1.2	0.4
Bone: post-yield work	0.6	0.9	1.2	1.0	1.0	0.9	-1.1	0.6
Progressive ratio test 1 active lever presses	0.9	1.1	2.0	0.9	1.0	0.9	-1.0	1.4
Progressive ratio test 1 breakpoint	1.0	1.2	2.1	1.0	1.0	1.0	-1.0	1.4
Progressive ratio test 1 inactive lever presses	1.3	1.8	3.4	1.2	1.2	1.3	-1.1	1.8
Progressive ratio test 2 active lever presses	0.2	0.3	1.0	0.2	0.1	-0.3	-0.5	1.0
Progressive ratio test 2 breakpoint	0.2	0.2	0.7	0.1	0.0	-0.4	-0.4	0.8
Progressive ratio test 2 inactive lever presses	0.2	0.3	1.4	0.4	0.4	0.1	-0.3	1.2
Incentive Sensitization - Responses	0.0	0.0	0.1	0.1	0.0	-0.3	-0.2	0.4
Incentive Sensitization - Breakpoint	0.0	0.1	0.2	-0.1	-0.1	-0.4	-0.1	0.3
Sum of active levers in priming session hrs 5-6	1.7	1.6	3.1	1.3	1.2	1.0	-1.8	0.8
Progressive ratio	1.1	1.7	1.9	-1.3	-1.3	-1.3	1.2	-1.4
Food seeking constrained by brief footshock	1.8	2.2	3.2	1.4	1.4	1.5	-1.3	1.8
Seeking ratio, punishment vs. effort	1.4	2.1	3.3	1.4	1.4	1.4	-1.1	1.8
Retroperitoneal fat weight	18.3	78.0	90.7	-9.5	-9.5	-9.1	7.8	-8.0
Reaction time number correct	0.3	0.5	0.8	0.9	0.9	0.7	-0.3	0.7
Reaction time mean minus median	0.1	0.2	1.1	0.2	0.2	0.3	-0.0	1.0
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.1	-0.0	0.1	0.3	0.1
Reaction time num false alarms	0.6	0.8	1.2	0.8	0.7	0.7	-1.1	1.1
Reaction time num false alarms AUC	0.7	1.1	1.3	1.0	1.0	0.9	-1.1	1.2
Reaction time trials correct on left	0.3	0.5	0.8	0.9	0.9	0.7	-0.3	0.7
Reaction time trials on left	0.3	0.6	0.9	0.9	0.9	0.8	-0.4	0.8
Reaction time mean	0.2	0.4	0.6	-0.8	-0.8	-0.7	0.4	0.4
Reaction time mean AUC	0.2	0.3	0.4	-0.6	-0.7	-0.5	0.3	0.5
Median of all reaction times	0.3	0.4	0.7	-0.8	-0.8	-0.7	0.3	0.3
Reaction time omissions	0.1	0.1	0.3	0.3	0.3	0.5	-0.3	0.3
Reaction time false alarm rate	0.2	0.3	0.7	0.4	0.4	0.4	-0.8	0.6
Reaction time premature initiation rate	0.1	0.2	0.2	-0.4	-0.4	-0.4	0.3	-0.5
Reaction time premature initiations	0.0	0.0	0.0	0.1	0.1	-0.0	0.2	-0.2
Std. dev. reaction times	0.1	0.2	0.2	-0.5	-0.5	-0.4	0.4	0.3
Reaction time trials completed	0.3	0.6	0.9	0.9	0.9	0.8	-0.4	0.8
Reaction time trials AUC	0.4	0.8	1.2	1.1	1.1	0.9	-0.5	1.0
Run reversals in cocaine runway, females	0.2	0.2	0.7	-0.1	-0.1	-0.1	0.8	0.4
Run reversals in cocaine runway, males	0.3	0.3	0.4	0.6	0.7	0.7	-0.1	0.6
Latency to leave start box in cocaine runway	0.4	0.4	0.6	0.6	0.6	0.7	-0.6	0.8
Latency to leave start box in cocaine runway, F	0.5	0.5	0.7	0.7	0.7	0.8	-0.9	0.5
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.4	-0.3	-0.2	0.3	0.2
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.2	-0.2	-0.1	0.4	0.3
Total sessions with >9 infusions	0.0	0.0	0.1	0.0	0.1	0.3	-0.1	0.3
Short access day 1 total inactive lever presses	4.3	5.7	7.2	2.3	2.4	2.6	-1.8	2.7
Short access day 10 total inactive lever presses	1.1	2.7	4.0	1.5	1.6	1.6	-1.6	2.0
Short access day 1 total infusions	0.9	1.2	1.8	0.8	0.9	1.2	-1.0	1.4
Short access day 10 total infusions	1.7	2.2	3.2	1.3	1.4	1.4	-1.4	1.8
Short access total infusions	0.2	0.3	0.6	0.2	0.3	0.3	-0.7	0.8
Short access day 1 locomotion	1.2	1.5	2.3	1.1	1.2	1.3	-0.9	1.5
Short access day 10 total locomotion	1.2	2.3	3.0	1.5	1.6	1.5	-1.7	1.2
Short access total locomotion	0.0	0.0	0.0	-0.1	0.0	0.1	-0.0	0.0
One hour access (0.3 mA shock)	0.6	0.6	2.1	0.6	0.5	0.2	-0.7	1.4
Compulsive drug intake	0.7	0.8	2.2	-0.8	-0.8	-0.6	1.5	-0.3
One hour access (shock baseline)	1.1	1.7	2.7	1.2	1.2	1.0	-1.6	1.4
Social response proportion	0.4	0.4	0.6	-0.8	-0.8	-0.7	0.6	0.1
Social responses	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.1	0.2
Social time	0.5	0.6	0.9	-0.9	-0.9	-0.8	0.8	-0.2
Soleus weight	5.8	17.0	19.7	4.4	4.4	4.4	-4.0	3.3
Bone: stiffness	0.0	0.0	0.1	0.1	0.1	0.1	-0.4	0.1
Tibialis anterior weight	4.2	14.2	17.6	4.1	4.1	4.2	-3.7	2.4
Time to tail flick, vehicle, before self-admin	0.9	1.0	1.3	-1.0	-1.0	-0.8	1.1	-0.9
Time to tail flick, vehicle, after self-admin	1.6	2.2	2.9	-1.5	-1.6	-1.7	0.9	-1.6
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.2	0.2	0.4	0.3	0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	0.4	0.3	-0.4	0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.0	-0.1	-0.5	-0.7	-0.5
Delta time to tail flick, test, before/after SA	1.3	1.3	2.1	1.3	1.2	0.9	-1.5	0.8
Tibia length	2.4	6.5	9.0	-2.8	-2.9	-3.0	2.2	-1.6
Ambulatory time before self-admin	0.1	0.1	0.2	0.3	0.2	-0.1	-0.4	-0.5
Ambulatory time after self-admin	0.5	0.6	0.9	-0.9	-0.9	-0.8	0.8	-0.3
Bone: tissue strength	0.2	0.2	0.4	-0.6	-0.6	-0.4	0.4	-0.2
Total heroin consumption	3.2	3.7	4.4	2.1	2.1	2.1	-2.1	1.1
Bone: trabecular number	3.9	6.5	6.8	2.6	2.6	2.6	-2.4	2.6
Bone: trabecular spacing	1.5	2.0	2.7	-1.4	-1.4	-1.5	0.9	-1.6
Bone: trabecular thickness	0.9	1.1	1.5	1.0	0.9	1.1	-1.0	1.2
Bone: trabecular tissue density	0.2	0.3	1.0	0.5	0.4	0.5	-0.3	1.0
Water consumed over 24 hours	0.6	0.8	1.4	0.9	0.8	0.6	-1.2	0.9
Number of responses in last shaping day	0.3	0.3	0.6	-0.5	-0.5	-0.7	0.3	-0.8