Hub : Genes

LOC134478834

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC134478834	0.1	0.07	2.3e-07	0.04	0.04	0.04	0.02	1.8e-05	2.0e-05	2.0e-05	2.6e-03
2	Liver	gene expression	LOC134478834	0.79	0.06	0.0e+00	0.62	0.54	0.64	0.64	1.4e-88	3.8e-71	3.1e-92	1.3e-92
3	Liver	alternative polyA	XM_063273750.1	0.88	0.03	0.0e+00	0.21	0.1	0.27	0.26	9.1e-23	7.3e-11	2.1e-29	4.2e-29
4	Liver	alternative polyA	XM_063273751.1	0.87	0.04	0.0e+00	0.2	0.11	0.24	0.25	4.7e-22	2.9e-12	1.9e-26	4.6e-27
5	Liver	mRNA stability	LOC134478834	0.85	0.04	1.6e-06	0.02	0.05	0.07	0.08	6.4e-03	6.8e-06	5.9e-08	1.5e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.0	0.1	0.3	-0.6	0.2	-0.1	0.0	-0.1
Area under the delay curve	0.0	0.1	0.2	-0.2	0.1	-0.1	-0.2	-0.5
BMI with tail	1.3	4.4	6.5	-2.5	2.4	-2.5	-1.7	-0.6
BMI without tail	0.5	2.8	4.2	-1.9	2.1	-2.1	-1.3	-0.6
Body weight	0.1	0.6	1.0	-0.5	0.6	-1.0	-1.0	-0.4
Weight adjusted by age	0.2	0.7	1.2	-0.9	1.0	-0.2	1.1	-0.6
Bone surface	0.1	0.1	0.3	-0.0	-0.0	0.4	0.6	0.5
Bone volume	0.1	0.3	0.5	0.6	-0.6	0.7	0.3	0.2
Breakpoint value in progressive ratio session	0.2	0.3	0.6	0.7	-0.3	0.0	-0.3	-0.8
Number of licking bursts	0.1	0.2	0.6	-0.8	0.5	-0.5	-0.3	-0.1
Context. condit. distance diff. score	1.0	1.2	3.3	0.5	-0.8	1.3	1.8	0.1
Locomotion velocity, session 1	1.5	1.7	3.1	-1.8	1.1	-1.4	-1.5	-0.3
Locomotion distance, session 1	0.1	0.1	0.3	0.1	-0.6	0.5	0.2	0.0
Locomotion velocity, session 2	0.1	0.1	0.2	-0.5	-0.1	0.0	-0.1	-0.3
Locomotion distance, session 2	0.0	0.1	0.2	0.1	-0.4	0.2	-0.1	0.3
Locomotion velocity, session 3	0.6	0.7	1.1	1.1	-0.9	0.9	0.7	-0.2
Locomotion distance, session 3	0.1	0.1	0.1	-0.3	-0.4	0.3	0.1	-0.2
Stereotopy head waving bouts, day 3	0.3	0.4	0.9	-0.2	1.0	-0.9	-0.5	-0.2
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.2	0.5	-0.4	-0.1	-0.2
Locomotion velocity, session 7	1.2	1.3	3.2	1.4	-1.8	1.1	-0.2	0.1
Locomotion distance, session 7	0.6	0.8	2.5	0.7	-1.6	1.0	-0.1	-0.0
Stereotopy head waving bouts, day 7	0.2	0.2	0.6	-0.4	0.8	-0.4	0.2	-0.2
Stereotopy head waving duration, day 7	0.3	0.3	0.8	-0.5	0.9	-0.6	-0.4	-0.4
Locomotion velocity, session 8	0.1	0.2	0.4	-0.7	-0.2	0.2	0.5	-0.2
Locomotion distance, session 8	0.9	1.3	2.4	0.6	-1.3	1.5	1.5	0.2
Degree of sensitization distance	0.8	0.8	1.7	1.3	-1.2	1.0	0.2	0.3
Degree of sensitization stereotypy	0.1	0.1	0.2	-0.2	0.2	0.2	0.5	-0.2
Conditioned locomotion	0.5	0.6	2.2	-1.5	0.5	-0.5	0.0	-0.3
Cocaine response after cond. corrected	0.2	0.3	0.9	0.4	-1.0	0.7	0.0	0.2
Cocaine response after cond. not corrected	0.3	0.4	0.9	0.5	-0.9	0.8	0.4	0.3
Cocaine response before conditioning	0.1	0.1	0.2	0.0	0.4	-0.0	0.5	0.2
Saline control response	0.6	0.9	1.2	1.0	-1.1	1.0	0.7	-0.9
Bone: connectivity density	0.2	0.4	1.0	-1.0	0.5	-0.5	-0.4	0.5
Bone: cortical apparent density	0.6	0.9	2.6	-0.9	0.3	-1.0	-1.6	-0.4
Bone: cortical area	0.3	0.5	2.1	1.5	-0.5	0.5	0.1	0.0
Bone: cortical porosity	1.0	1.1	2.9	-1.7	1.0	-0.8	0.1	-0.9
Bone: cortical porosity	1.8	2.0	3.9	-2.0	1.7	-1.5	-0.4	-0.8
Bone: cortical thickness	0.2	0.3	0.5	-0.2	0.7	-0.7	-0.5	-0.1
Bone: cortical thickness	0.4	0.5	0.9	0.6	-0.6	0.8	0.9	-0.4
Bone: cortical tissue density	0.7	1.1	2.7	-1.0	0.4	-1.1	-1.7	-0.4
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	-0.7	0.8	-1.0	-0.8	-0.2
Condit. Reinf. active-inactive response ratio	1.1	1.2	2.6	-1.1	1.6	-1.4	-0.5	0.0
Condit. Reinf. active responses	0.1	0.1	0.5	-0.3	-0.0	-0.3	-0.7	0.0
Condit. Reinf. inactive responses	0.5	0.7	1.8	0.9	-1.3	1.0	-0.1	0.2
Incentive salience index mean	0.1	0.2	0.3	-0.5	0.2	-0.4	-0.6	0.1
Condit. Reinf. lever presses	0.1	0.2	0.7	-0.9	0.0	-0.0	-0.0	0.2
Condit. Reinf. active minus inactive responses	0.0	0.1	0.2	-0.3	-0.4	0.2	-0.1	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.2	-0.5	0.4	0.1	0.2
Condit. Reinf. active responses	0.1	0.1	0.3	-0.2	-0.6	0.3	0.0	0.0
Condit. Reinf. inactive responses	0.2	0.2	0.6	0.1	-0.8	0.6	0.3	-0.4
Condit. Reinf. lever presses	1.0	1.5	2.5	1.0	-1.2	1.5	1.6	-0.4
Condit. Reinf. lever reinforcers received	0.1	0.2	0.5	-0.2	-0.7	0.6	0.4	0.0
Conditioned reinforcement - actives	0.2	0.6	2.7	-0.4	0.2	0.1	0.6	-1.6
Conditioned reinforcement - inactives	0.5	1.3	2.8	0.7	-0.8	1.1	1.1	-1.7
Conditioned locomotion	0.4	0.6	3.1	0.1	-0.1	-0.1	-0.2	-1.8
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.4	-0.7	0.4	-0.0	0.0
Patch foraging indifference point AUC	0.6	1.5	3.9	1.4	-2.0	1.1	-0.6	-0.0
Delay disc. indifference point, 0s delay	0.2	0.2	0.7	-0.8	0.2	-0.3	-0.1	-0.5
Delay disc. indifference point, 16s delay	0.4	0.6	1.1	-0.6	1.0	-0.9	-0.9	0.1
Delay disc. indifference point, 2s delay	1.1	1.2	3.6	0.9	-1.9	1.2	0.0	-0.2
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.1	0.2	-0.4	-0.5	0.6
Delay disc. indifference point, 4s delay	0.3	0.3	1.5	-0.0	-0.4	0.2	-0.1	-1.2
Delay disc. indifference point, 8s delay	0.6	0.9	1.6	-1.1	1.3	-1.1	-0.7	-0.4
Indifference point function ln k	0.2	0.7	2.1	-0.5	1.5	-0.9	0.1	0.1
Indifference point function log k	0.2	0.7	2.1	-0.5	1.5	-0.9	0.1	0.1
Patch foraging total patch changes 0 sec	0.1	0.3	0.7	0.5	-0.8	0.6	0.1	-0.1
Patch foraging total patch changes 12 sec	0.4	0.5	1.7	0.6	-0.7	-0.1	-1.3	0.2
Patch foraging total patch changes 18 sec	0.1	0.1	0.4	-0.2	-0.6	0.4	-0.0	-0.3
Patch foraging total patch changes 24 sec	0.1	0.5	1.3	0.8	-1.1	0.7	-0.2	-0.4
Patch foraging total patch changes 6 sec	0.6	1.0	2.4	1.2	-1.6	1.0	-0.2	0.2
Patch foraging time to switch 0 sec	0.8	3.2	7.1	-2.3	2.7	-1.9	-0.2	-0.3
Patch foraging water rate 0 sec	0.4	1.4	3.1	1.8	-1.7	1.0	-0.3	0.1
Patch foraging water rate 12 sec	0.2	0.6	0.9	0.9	-0.8	0.9	0.7	-0.3
Patch foraging water rate 18 sec	0.8	1.7	2.9	1.7	-1.7	1.4	0.5	0.9
Patch foraging water rate 24 sec	1.3	1.8	2.9	1.2	-1.7	1.7	1.3	-0.3
Patch foraging water rate 6 sec	0.8	1.2	3.2	1.8	-1.1	1.0	0.4	-0.5
Seeking ratio, delayed vs. immediate footshock	0.7	1.0	1.7	0.8	-1.1	1.3	1.0	0.8
Distance traveled before self-admin	0.1	0.1	0.3	0.5	-0.1	0.0	0.2	0.6
Distance traveled after self-admin	2.3	4.0	6.6	1.9	-2.5	2.6	1.9	-0.1
Extensor digitorum longus weight	6.0	23.9	46.8	-6.8	6.4	-5.2	-1.3	-1.4
Bone: elastic displacement	0.2	0.2	0.8	-0.6	0.2	0.1	0.9	-0.1
Bone: elastic work	0.5	0.7	2.0	-1.0	-0.1	0.4	1.4	-0.5
Bone: endosteal estimation	1.0	2.5	4.4	2.1	-1.9	1.8	1.1	0.3
Bone: endosteal perimeter	0.4	1.0	1.7	1.3	-0.8	1.1	1.2	0.0
Epididymis fat weight	0.1	0.7	2.3	-0.1	0.4	-1.0	-1.5	-0.5
Delta time in closed arm before/after self-admin	0.8	0.7	1.1	-1.0	1.0	-1.0	-0.6	0.5
Delta time in open arm before/after self-admin	0.3	0.3	0.6	0.8	-0.5	0.2	-0.3	-0.8
Diff in mean of infusions in LGA sessions	0.1	0.2	1.1	1.0	0.2	-0.0	0.2	0.1
Delay discount exponential model param	0.0	0.0	0.2	0.1	0.1	-0.0	0.2	0.4
Extinction: sum of active levers before priming	0.0	0.1	0.1	-0.4	0.0	0.0	0.3	-0.3
Active lever presses in extinction session 6	0.5	0.5	1.3	1.1	-0.6	0.1	-0.7	-0.1
Bone: final force	0.1	0.2	0.5	0.7	-0.3	0.1	-0.1	0.6
Bone: final moment	0.1	0.2	0.6	0.8	-0.2	0.0	-0.2	0.6
Food consumed during 24 hour testing period	0.9	1.8	3.3	0.7	-1.8	1.7	1.2	-0.9
Glucose	0.4	0.6	1.2	1.1	-1.1	0.8	0.2	0.3
Heart weight	0.2	0.3	0.8	0.3	0.9	-0.6	0.1	0.3
Delay discount hyperbolic model param	0.1	0.1	0.3	-0.1	0.4	-0.2	0.1	0.5
Intermittent access intake day 1-15 change	0.1	0.4	1.1	-1.0	0.8	-0.5	-0.2	0.5
Intermittent access intake escalation	0.1	0.5	1.0	-1.0	0.9	-0.6	-0.1	0.3
Intermittent access intake escalation 2	0.1	0.2	0.6	0.8	-0.4	0.6	0.3	0.2
Intermitt. access day 1 inactive lever presses	0.2	2.1	3.2	1.3	-1.8	1.8	1.0	-1.3
Intermitt. access day 15 inactive lever presses	0.5	2.6	4.4	1.8	-2.1	1.7	0.7	-1.5
Intermitt. access escalation Index	0.2	0.7	1.8	-0.8	1.0	-0.4	0.6	-1.3
Intermittent access day 1 total infusions	0.2	0.6	2.7	-0.2	-0.1	0.1	0.3	-1.6
Intermittent access day 15 total infusions	0.0	0.1	0.3	-0.0	0.0	0.2	0.4	-0.5
Intermittent access terminal intake (last 3 days)	0.3	0.6	1.1	1.0	-0.8	0.9	0.5	-0.5
Intermittent access total infusions	0.2	0.3	0.7	0.4	-0.3	0.4	0.6	-0.8
Intermittent access day 1 locomotion	0.6	1.1	4.7	0.1	-0.6	0.3	0.2	-2.2
Intermittent access day 15 total locomotion	0.0	0.2	0.6	0.4	-0.1	-0.4	-0.8	-0.1
Intermittent access total locomotion	0.4	0.4	1.3	-0.1	0.2	-0.6	-0.6	-1.2
Intermittent access standard deviation	0.3	1.3	2.0	0.7	-1.1	1.4	1.1	-1.3
Left kidney weight	0.0	0.3	1.1	1.0	-0.2	0.2	0.2	0.3
Right kidney weight	0.1	0.7	2.6	1.6	-0.4	0.1	-0.6	0.5
Cocaine induced anxiety	0.1	0.1	0.3	-0.3	0.5	-0.3	-0.2	-0.4
Post-drug Anxiety	0.0	0.0	0.1	0.2	0.2	-0.2	-0.3	-0.2
Baseline Anxiety	0.3	0.5	0.9	0.5	-0.7	0.8	0.9	0.5
Tail length	0.3	1.6	2.8	1.7	-1.5	1.4	1.0	-0.1
Length with tail	0.5	2.2	4.6	2.1	-1.6	1.6	1.2	0.3
Length without tail	0.2	0.9	2.0	1.4	-1.1	0.9	0.7	0.4
Times rat made contact with spout	0.1	0.1	0.5	-0.0	-0.4	0.3	-0.1	-0.7
Lifetime Intake	0.4	0.4	1.9	-0.4	0.1	-0.0	0.4	-1.4
Liver weight, left	0.2	0.4	0.9	0.4	-0.9	0.2	-0.9	-0.4
Liver weight, right	0.5	0.9	2.7	0.8	-1.6	1.0	0.0	-0.4
Locomotor activity	0.5	0.8	1.1	1.0	-0.9	1.0	0.9	0.4
Locomotor testing distance	0.3	0.8	1.3	0.8	-0.5	0.8	1.2	0.9
Locomotor testing rearing	0.2	0.7	1.8	0.8	-0.4	0.8	1.3	0.3
Locomotion in novel chamber	0.3	0.3	1.2	0.2	-0.1	0.3	0.6	-1.1
Locomotion in novel chamber post-restriction	0.1	0.4	1.6	1.3	-0.5	0.2	-0.4	-0.0
Fecal boli incidents, locomotor time 1	0.2	0.5	1.6	-0.3	1.3	-0.4	0.7	-0.1
Change in fecal boli incidents, locomotor task	0.3	0.3	0.9	-0.9	0.2	-0.6	-0.3	-0.4
Time >=10cm from walls, locomotor time 1	0.8	0.9	1.7	-1.3	1.3	-0.6	0.4	-1.0
Bouts of movement, locomotor time 1	0.4	0.5	1.5	0.3	1.2	-0.7	-0.0	0.6
Total resting periods, locomotor time 1	0.3	0.4	1.1	0.3	1.0	-0.6	-0.1	0.5
Rest time, locomotor task time 1	1.0	1.6	2.7	1.6	-0.8	1.0	0.8	1.7
Distance moved, locomotor task time 1	0.4	1.1	3.2	-1.5	0.4	-0.3	0.2	-1.8
Vertical activity count, locomotor time 1	0.1	0.9	2.1	-0.3	-0.2	-0.7	-1.5	-1.4
Time >=10cm from walls, locomotor time 2	0.4	1.1	3.5	-1.1	0.5	-0.0	0.6	-1.9
Bouts of movement, locomotor time 2	0.1	0.2	0.6	0.4	-0.1	0.3	0.2	0.7
Total resting periods, locomotor time 2	0.1	0.3	1.2	0.3	-0.0	0.1	0.0	1.1
Rest time, locomotor task time 2	0.9	1.5	4.9	0.9	-0.9	0.7	0.6	2.2
Distance moved, locomotor task time 2	1.2	1.6	2.9	-1.7	1.2	-0.8	-0.2	-1.7
Vertical activity count, locomotor time 2	0.4	0.9	2.7	-0.4	0.1	-0.6	-1.1	-1.6
Light reinforcement 1	0.2	0.9	2.6	1.6	-1.1	0.9	0.1	0.1
Light reinforcement 2	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.2
Bone: marrow area	1.0	2.4	4.2	2.0	-1.8	1.8	1.1	0.3
Bone: maximum diameter	0.1	0.2	1.1	1.0	0.1	-0.1	-0.3	0.1
Bone: maximum force	0.2	0.4	1.2	1.1	-0.6	0.6	0.4	0.4
Bone: maximum moment	0.3	0.5	1.6	1.3	-0.6	0.6	0.3	0.3
Mean time between licks in bursts	0.5	2.8	5.0	-1.3	2.2	-2.2	-1.4	0.6
Mean num. licks in bursts	0.2	0.6	1.1	1.0	-1.1	0.9	0.2	-0.4
Cd content in liver	2.2	2.5	6.1	-1.9	2.5	-1.5	0.2	-0.5
Co content in liver	0.3	0.4	0.8	-0.0	0.4	-0.7	-0.9	0.6
Cu content in liver	0.1	0.1	0.4	0.6	-0.1	0.2	0.2	-0.4
Fe content in liver	0.6	0.8	2.0	-0.6	0.7	-1.1	-1.4	-0.0
K content in liver	0.2	0.2	0.5	-0.0	-0.6	0.1	-0.7	-0.3
Mg content in liver	0.2	0.2	0.6	0.3	-0.3	-0.1	-0.8	0.3
Mn content in liver	0.1	0.1	0.2	-0.3	0.5	-0.2	0.0	-0.1
Na content in liver	0.2	0.2	0.6	0.0	-0.8	0.4	-0.2	-0.6
Rb content in liver	1.3	1.5	2.7	-0.9	1.5	-1.6	-1.3	0.0
Se content in liver	0.2	0.2	0.4	0.5	-0.2	-0.2	-0.6	0.5
Sr content in liver	0.6	0.6	2.2	0.5	0.2	0.5	1.5	-0.2
Zn content in liver	0.4	0.4	0.8	-0.9	0.7	-0.7	-0.5	-0.1
Bone: minimum diameter	4.1	7.9	18.3	4.3	-3.5	2.8	1.0	0.2
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.1	-0.4	0.5	0.4	-0.3
Time in novel zone, hab. session 1	0.5	0.5	1.0	-0.2	0.8	-0.9	-1.0	0.0
Total zone transitions, hab. session 1	0.1	0.2	0.3	-0.4	-0.4	0.5	0.4	0.1
Total locomotion distance, hab. session 1	1.1	1.5	3.2	0.8	-1.8	1.6	1.0	0.3
Locomotion velocity, hab. session 1	1.0	1.5	2.5	0.8	-1.6	1.6	1.3	0.3
Time in familiar zone, hab. session 2	0.2	0.2	0.5	-0.7	0.5	-0.1	0.3	-0.6
Time in novel zone, hab. session 2	0.5	0.6	1.1	1.1	0.1	-0.5	-1.0	0.6
Total zone transitions, hab. session 2	0.3	0.3	1.0	0.5	-0.2	0.6	1.0	0.2
Total locomotion distance, hab. session 2	1.0	1.3	1.8	1.3	-1.0	1.3	1.3	0.3
Locomotion velocity, hab. session 2	0.9	1.2	1.8	1.1	-1.0	1.3	1.3	0.3
Novel to familiar place preference ratio	0.3	0.4	1.8	0.2	-0.1	-0.5	-1.3	0.2
Novelty place preference	0.5	0.6	2.4	0.0	0.3	-0.8	-1.5	0.1
Time in novel zone, NPP test	0.5	0.7	2.7	0.3	0.1	-0.7	-1.6	0.1
Total zone transitions, NPP test	0.1	0.1	0.1	-0.3	-0.0	0.3	0.4	-0.3
Total locomotion distance, NPP test	0.4	0.5	1.2	0.2	-0.7	0.9	1.1	-0.1
Locomotion velocity, NPP test	0.3	0.4	1.2	-0.2	-0.3	0.7	1.1	-0.2
Intraocular pressure	0.3	0.5	1.0	-0.3	0.9	-1.0	-0.7	0.3
Delta distance traveled before/after self-admin	1.7	1.9	4.3	0.7	-2.1	1.9	1.0	-0.1
Delta ambulatory time before/after self-admin	0.6	1.0	2.3	0.4	-1.5	1.4	0.8	-0.1
Parametrial fat weight	0.5	1.1	3.3	0.9	-1.8	0.9	-0.6	-0.3
Pavlov. Cond. lever latency	0.3	0.4	1.0	-0.8	1.0	-0.6	0.4	-0.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.5	-0.7	-0.0	0.0	0.0	-0.2
Pavlov. Cond. change in total contacts	0.1	0.2	0.4	0.4	-0.2	-0.1	-0.6	0.5
Pavlov. Cond. index score	0.1	0.1	0.3	-0.1	-0.6	0.1	-0.6	0.1
Pavlov. Cond. latency score	0.1	0.1	0.4	0.1	-0.7	0.3	-0.4	0.1
Pavlov. Cond. lever contacts	0.3	0.4	0.8	0.8	-0.9	0.6	-0.3	0.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.4	0.0	0.2	0.4	-0.0
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.8	0.9	-0.3	0.0	-0.6	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	-0.1	-0.7	0.2	-0.5	0.1
Pavlov. Cond. response bias	0.1	0.1	0.4	-0.2	-0.6	0.2	-0.5	0.1
Pavlov. Cond. lever latency	0.5	0.7	2.4	0.6	-0.1	-0.6	-1.5	0.6
Pavlov. Cond. magazine entry latency	0.4	0.6	1.3	-1.1	1.0	-0.5	0.5	0.5
Pavlov. Cond. change in total contacts	0.1	0.3	1.2	-0.6	0.3	0.2	1.1	-0.0
Pavlov. Cond. index score	0.4	0.6	2.0	-0.9	0.5	0.2	1.4	-0.2
Pavlov. Cond. latency score	0.4	0.7	1.9	-1.0	0.7	0.0	1.4	-0.0
Pavlov. Cond. lever contacts	0.5	0.7	2.3	-0.2	-0.2	0.8	1.5	-0.6
Pavlov. Cond. magazine entry number	0.8	1.0	2.5	1.6	-1.3	0.7	-0.7	-0.2
Pavlov. Cond. intertrial magazine entries	0.6	1.3	2.7	1.5	-1.6	1.2	0.1	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.5	1.4	-0.9	0.5	0.1	1.2	-0.1
Pavlov. Cond. response bias	0.4	0.5	1.5	-0.8	0.4	0.2	1.2	-0.4
Time in closed arm before self-admin	0.4	0.7	2.5	1.6	-0.7	0.5	0.0	0.4
Time in closed arm after self-admin	0.1	0.1	0.5	0.7	0.3	-0.1	0.3	-0.1
Time in open arm before self-admin	0.7	0.8	1.9	-1.4	0.4	-0.4	-0.1	1.3
Time in open arm after self-admin	0.2	0.3	0.7	-0.0	-0.8	0.5	-0.3	-0.5
Bone: periosteal estimation	0.6	1.5	4.1	2.0	-1.3	1.2	0.6	0.3
Bone: periosteal perimeter	0.3	0.6	1.4	1.2	-0.5	0.9	0.9	-0.1
Bone: post-yield work	0.1	0.2	0.6	0.8	-0.1	0.2	-0.1	-0.4
Progressive ratio test 1 active lever presses	0.1	0.2	0.9	0.3	-0.0	-0.1	0.2	-1.0
Progressive ratio test 1 breakpoint	0.1	0.3	1.0	0.3	-0.1	0.1	0.4	-1.0
Progressive ratio test 1 inactive lever presses	0.8	2.1	3.4	1.2	-1.9	1.7	1.0	-1.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	0.6	0.1	0.1	0.1	-0.6
Progressive ratio test 2 breakpoint	0.1	0.1	0.4	0.6	0.1	0.1	0.1	-0.6
Progressive ratio test 2 inactive lever presses	0.5	1.5	2.2	1.3	-1.2	1.2	0.8	-1.5
Incentive Sensitization - Responses	0.0	0.1	0.3	0.1	0.5	-0.2	-0.1	0.0
Incentive Sensitization - Breakpoint	0.0	0.1	0.2	0.1	0.5	-0.2	-0.0	0.1
Sum of active levers in priming session hrs 5-6	0.7	0.7	2.3	-0.3	-0.4	0.6	0.8	-1.5
Progressive ratio	0.0	0.1	0.4	0.1	-0.1	0.1	0.6	0.0
Food seeking constrained by brief footshock	0.2	0.3	0.4	-0.6	0.4	-0.6	-0.6	0.6
Seeking ratio, punishment vs. effort	0.1	0.3	1.0	0.3	-0.4	0.1	-1.0	0.4
Retroperitoneal fat weight	0.1	0.3	1.0	0.5	-0.5	-0.2	-1.0	-0.3
Reaction time number correct	0.1	0.2	0.5	0.7	-0.0	0.4	0.5	-0.0
Reaction time mean minus median	0.1	0.6	1.2	-1.1	0.8	-0.7	-0.4	-0.9
Reaction time mean minus median AUC	0.1	0.7	1.0	-0.5	0.8	-0.9	-1.0	-0.7
Reaction time num false alarms	0.2	0.3	1.1	0.5	-0.2	-0.2	-1.0	0.3
Reaction time num false alarms AUC	0.1	0.3	1.2	-0.1	0.1	-0.6	-1.1	0.3
Reaction time trials correct on left	0.1	0.2	0.5	0.7	-0.0	0.4	0.5	-0.0
Reaction time trials on left	0.0	0.2	0.5	0.7	0.0	0.4	0.5	-0.0
Reaction time mean	0.3	0.6	0.9	-0.9	1.0	-0.6	-0.1	-0.9
Reaction time mean AUC	0.2	0.5	0.8	-0.7	0.9	-0.7	-0.3	-0.8
Median of all reaction times	0.3	0.5	0.8	-0.8	0.9	-0.5	0.0	-0.8
Reaction time omissions	0.4	0.7	1.5	-0.9	1.2	-0.9	-0.3	0.4
Reaction time false alarm rate	0.3	0.5	1.6	-0.4	0.1	-0.7	-1.3	0.3
Reaction time premature initiation rate	0.3	0.5	2.1	1.5	-0.6	0.4	-0.0	0.1
Reaction time premature initiations	0.3	0.8	3.2	1.8	-0.6	0.6	0.1	-0.1
Std. dev. reaction times	0.1	0.4	0.6	-0.6	0.8	-0.5	-0.1	-0.7
Reaction time trials completed	0.0	0.2	0.5	0.7	0.0	0.4	0.5	-0.0
Reaction time trials AUC	0.0	0.1	0.4	0.6	0.1	0.2	0.3	-0.0
Run reversals in cocaine runway, females	1.4	1.5	2.1	1.4	-1.4	1.4	0.5	-1.3
Run reversals in cocaine runway, males	0.4	0.4	1.0	-1.0	0.6	-0.6	-0.5	0.3
Latency to leave start box in cocaine runway	1.7	2.3	4.2	2.1	-1.6	1.8	0.9	0.7
Latency to leave start box in cocaine runway, F	2.8	3.5	5.5	2.3	-2.3	2.2	0.9	0.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.4	-0.0	0.4	0.4	0.1
Std. dev. time between licks in bursts	0.5	0.9	2.2	-1.5	1.0	-1.1	-0.5	0.0
Total sessions with >9 infusions	1.4	1.7	3.0	-1.7	1.3	-1.3	-0.3	-1.5
Short access day 1 total inactive lever presses	0.7	1.5	2.2	0.8	-1.2	1.5	1.5	-1.0
Short access day 10 total inactive lever presses	0.3	2.1	3.5	1.6	-1.4	1.9	1.4	-0.5
Short access day 1 total infusions	0.2	0.3	0.9	0.2	-0.5	0.5	0.3	-1.0
Short access day 10 total infusions	0.5	0.7	2.5	-0.9	0.3	-0.1	0.6	-1.6
Short access total infusions	0.7	0.9	2.5	-1.2	0.6	-0.6	0.1	-1.6
Short access day 1 locomotion	0.7	1.1	3.9	-1.1	0.2	-0.1	0.5	-2.0
Short access day 10 total locomotion	0.2	0.7	3.6	-0.0	0.2	-0.2	-0.1	-1.9
Short access total locomotion	0.8	1.1	4.0	-1.0	0.5	-0.6	-0.1	-2.0
One hour access (0.3 mA shock)	0.2	0.2	0.4	0.2	-0.4	0.3	0.5	-0.7
Compulsive drug intake	0.4	0.6	1.0	0.1	-0.9	1.0	1.0	0.4
One hour access (shock baseline)	0.1	0.3	1.0	0.1	0.3	-0.5	-0.5	-1.0
Social response proportion	0.6	0.8	1.8	0.6	-1.3	0.7	-0.5	1.0
Social responses	0.5	0.6	1.0	0.8	-0.9	0.2	-0.8	1.0
Social time	0.3	0.5	1.2	1.1	-0.6	0.6	0.0	0.7
Soleus weight	0.5	1.6	3.8	-1.4	0.6	0.2	1.9	-1.3
Bone: stiffness	0.5	1.0	3.2	1.8	-0.9	0.4	-0.8	0.5
Tibialis anterior weight	2.2	7.5	14.4	-3.4	3.8	-3.0	-0.9	-1.1
Time to tail flick, vehicle, before self-admin	1.0	1.2	1.8	1.3	-1.3	0.9	0.0	1.4
Time to tail flick, vehicle, after self-admin	0.7	1.3	1.7	1.3	-1.1	1.3	1.3	-0.7
Time to tail flick, test, before self-admin	0.1	0.1	0.3	-0.6	0.0	0.2	0.5	0.3
Time to tail flick, test, after self-admin	0.7	0.8	1.6	1.3	-1.2	0.7	-0.4	0.6
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.9	0.1	-0.1	0.1	0.3	-1.4
Delta time to tail flick, test, before/after SA	0.5	0.7	2.0	1.4	-0.8	0.3	-0.7	0.2
Tibia length	0.4	1.1	3.9	2.0	-0.6	0.4	-0.3	1.1
Ambulatory time before self-admin	0.1	0.3	1.0	0.7	-0.1	0.0	0.1	1.0
Ambulatory time after self-admin	2.0	3.2	5.4	2.0	-2.3	2.1	1.3	0.3
Bone: tissue strength	0.6	0.6	1.3	1.1	-1.0	0.8	0.4	0.1
Total heroin consumption	0.2	0.3	0.5	0.7	-0.7	0.1	-0.5	0.4
Bone: trabecular number	0.1	0.2	0.5	-0.7	-0.0	-0.2	-0.6	0.4
Bone: trabecular spacing	0.4	0.5	1.6	0.5	0.4	-0.7	-1.3	-0.4
Bone: trabecular thickness	0.3	0.5	1.1	0.1	-0.5	0.8	1.1	-0.4
Bone: trabecular tissue density	0.4	0.8	1.4	-0.3	1.2	-1.2	-1.0	-0.4
Water consumed over 24 hours	0.4	0.7	1.6	0.9	-1.3	1.1	0.4	-0.2
Number of responses in last shaping day	0.8	1.0	2.3	-1.5	0.5	-0.7	-0.4	-1.4