LOC120103631

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr6_137135232_137143021	0.02	0.02	6.8e-03	0.01	0.01	0.01	0.01	1.5e-02	1.4e-02	3.1e-02	1.3e-02
2	Liver	gene expression	LOC120103631	0.17	0.11	0.0e+00	0.11	0.14	0.12	0.14	5.0e-12	8.4e-16	1.8e-13	1.2e-15
3	Adipose	gene expression	LOC120103631	0.04	0.04	1.2e-04	0.02	0.02	0.02	0.01	2.0e-03	5.5e-03	3.6e-03	7.6e-03
4	Liver	intron excision ratio	chr6_137137551_137143021	0.03	0.03	1.2e-03	0.01	0.02	0.01	0.01	8.6e-03	6.2e-03	2.5e-02	1.4e-02
5	Liver	mRNA stability	LOC120103631	0.03	0.03	1.5e-03	0.02	0.02	0.02	0.02	1.6e-03	2.8e-03	2.2e-03	2.5e-03
6	IL	gene expression	LOC120103631	0.19	0.2	6.1e-03	0.05	0.09	0.03	0.07	3.0e-02	3.6e-03	7.3e-02	9.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.1	0.1	0.3	0.3	-0.1	-0.6	0.2	-0.3	0.1
Area under the delay curve	0.2	0.2	0.5	-0.7	-0.5	-0.6	0.3	-0.3	0.3
BMI with tail	3.3	11.4	13.0	-3.2	-3.6	-3.3	3.4	-3.5	3.2
BMI without tail	2.0	6.0	7.6	-2.2	-2.8	-2.4	2.5	-2.6	2.3
Body weight	0.5	2.2	5.1	2.3	1.2	1.3	-1.2	1.2	-1.4
Weight adjusted by age	0.3	0.4	0.5	0.7	0.5	0.7	-0.6	0.6	-0.7
Bone surface	0.1	0.1	0.3	-0.3	-0.3	-0.6	0.2	-0.2	0.1
Bone volume	0.0	0.1	0.2	-0.3	-0.3	-0.5	0.2	-0.2	0.0
Breakpoint value in progressive ratio session	0.1	0.1	0.3	0.5	-0.0	-0.2	0.3	-0.3	0.4
Number of licking bursts	0.1	0.1	0.6	-0.8	-0.3	-0.1	0.2	-0.2	0.3
Context. condit. distance diff. score	3.2	3.9	4.8	1.6	1.9	1.8	-2.1	2.2	-2.2
Locomotion velocity, session 1	0.1	0.1	0.2	0.4	0.4	0.3	-0.4	0.4	-0.4
Locomotion distance, session 1	0.7	0.8	1.2	-0.5	-0.9	-1.1	1.0	-1.0	1.0
Locomotion velocity, session 2	0.1	0.1	0.5	-0.7	-0.1	0.2	0.0	-0.0	-0.0
Locomotion distance, session 2	0.3	0.5	0.9	-1.0	-0.7	-0.7	0.6	-0.6	0.5
Locomotion velocity, session 3	0.1	0.2	0.3	-0.5	-0.3	-0.4	0.4	-0.3	0.3
Locomotion distance, session 3	0.1	0.1	0.4	-0.6	0.0	-0.1	-0.0	0.1	-0.0
Stereotopy head waving bouts, day 3	0.0	0.1	0.2	0.0	0.3	0.4	-0.2	0.1	-0.1
Stereotopy head waving duration, day 3	0.2	0.2	0.5	0.5	0.5	0.7	-0.4	0.3	-0.4
Locomotion velocity, session 7	0.2	0.2	0.4	-0.0	-0.4	-0.6	0.5	-0.5	0.6
Locomotion distance, session 7	0.7	0.9	1.2	-1.1	-1.0	-0.9	0.9	-0.8	0.9
Stereotopy head waving bouts, day 7	1.1	1.3	2.4	1.6	1.2	0.9	-1.0	1.0	-1.0
Stereotopy head waving duration, day 7	0.6	0.7	1.5	1.2	0.9	0.7	-0.7	0.7	-0.7
Locomotion velocity, session 8	0.9	1.1	1.2	1.1	1.0	0.8	-1.0	1.1	-1.1
Locomotion distance, session 8	0.1	0.2	0.5	0.2	0.3	0.2	-0.5	0.6	-0.7
Degree of sensitization distance	0.1	0.2	0.3	0.0	-0.4	-0.3	0.4	-0.4	0.5
Degree of sensitization stereotypy	0.4	0.4	1.0	1.0	0.7	0.3	-0.6	0.5	-0.5
Conditioned locomotion	1.5	1.7	2.6	1.6	1.3	1.4	-1.2	1.2	-1.1
Cocaine response after cond. corrected	0.7	0.9	1.5	-0.3	-0.8	-0.6	1.1	-1.2	1.2
Cocaine response after cond. not corrected	2.1	2.4	3.3	-1.1	-1.5	-1.4	1.7	-1.8	1.8
Cocaine response before conditioning	2.2	2.7	4.7	-2.2	-1.7	-1.8	1.4	-1.3	1.2
Saline control response	0.0	0.0	0.1	0.1	0.1	-0.2	-0.1	0.2	-0.2
Bone: connectivity density	0.2	0.3	0.5	0.7	0.5	0.0	-0.6	0.6	-0.7
Bone: cortical apparent density	7.0	9.6	11.2	3.0	3.2	3.4	-3.1	3.0	-2.9
Bone: cortical area	0.2	0.4	1.0	0.7	0.6	1.0	-0.4	0.3	-0.3
Bone: cortical porosity	0.5	0.5	0.9	0.2	0.6	0.5	-0.8	0.9	-1.0
Bone: cortical porosity	0.0	0.1	0.1	-0.4	-0.0	-0.2	-0.1	0.2	-0.3
Bone: cortical thickness	0.4	0.7	2.1	1.5	0.8	1.0	-0.4	0.3	-0.2
Bone: cortical thickness	0.9	1.1	1.5	1.1	1.1	1.2	-1.0	0.9	-1.0
Bone: cortical tissue density	6.9	9.4	11.2	3.0	3.2	3.3	-3.1	2.9	-2.9
Condit. Reinf. active minus inactive responses	0.6	0.7	1.0	-0.4	-0.8	-0.7	0.9	-1.0	1.0
Condit. Reinf. active-inactive response ratio	2.7	2.9	3.3	-1.4	-1.8	-1.6	1.8	-1.8	1.8
Condit. Reinf. active responses	0.2	0.2	0.4	0.3	-0.3	-0.2	0.5	-0.6	0.6
Condit. Reinf. inactive responses	1.6	2.0	3.0	1.7	1.5	1.5	-1.3	1.2	-1.1
Incentive salience index mean	0.6	0.7	1.1	-0.0	-0.7	-0.8	0.9	-1.0	1.0
Condit. Reinf. lever presses	0.2	0.2	0.4	0.2	-0.3	-0.5	0.5	-0.6	0.6
Condit. Reinf. active minus inactive responses	0.7	0.9	1.4	0.7	0.9	0.7	-1.0	1.2	-1.1
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.1	0.9	0.8	0.8	-1.0	1.1	-1.0
Condit. Reinf. active responses	0.0	0.1	0.1	-0.3	0.1	-0.1	-0.2	0.3	-0.4
Condit. Reinf. inactive responses	0.7	0.9	1.7	-1.3	-0.8	-0.9	0.8	-0.9	0.7
Condit. Reinf. lever presses	1.3	1.8	4.5	-2.1	-1.4	-1.3	1.1	-0.9	0.8
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	-0.1	0.2	0.0	-0.4	0.4	-0.5
Conditioned reinforcement - actives	0.3	0.5	0.7	0.5	0.8	0.9	-0.8	0.7	-0.7
Conditioned reinforcement - inactives	0.2	0.3	0.8	0.9	0.6	0.3	-0.5	0.4	-0.5
Conditioned locomotion	0.1	0.2	0.3	-0.1	-0.4	-0.5	0.5	-0.5	0.4
Patch foraging indifference point 0 sec	3.9	7.3	10.4	3.2	2.8	2.7	-2.5	2.4	-2.4
Patch foraging indifference point AUC	1.5	2.2	5.3	2.3	1.6	1.2	-1.2	1.2	-0.9
Delay disc. indifference point, 0s delay	0.2	0.3	0.4	0.7	0.6	0.4	-0.5	0.4	-0.5
Delay disc. indifference point, 16s delay	0.3	0.3	1.1	-1.0	-0.6	-0.4	0.4	-0.4	0.4
Delay disc. indifference point, 2s delay	0.7	0.8	2.0	-1.4	-0.8	-0.8	0.7	-0.7	0.7
Delay disc. indifference point, 24s delay	0.4	0.5	0.8	-0.9	-0.7	-0.7	0.6	-0.6	0.6
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.1	0.4	0.4	-0.6	0.6	-0.6
Delay disc. indifference point, 8s delay	0.1	0.2	0.5	-0.3	-0.4	-0.7	0.3	-0.3	0.2
Indifference point function ln k	0.9	1.6	2.4	0.8	1.1	1.3	-1.4	1.4	-1.5
Indifference point function log k	0.9	1.6	2.4	0.8	1.1	1.3	-1.4	1.4	-1.5
Patch foraging total patch changes 0 sec	4.4	8.3	11.7	3.4	3.0	2.9	-2.7	2.6	-2.6
Patch foraging total patch changes 12 sec	3.6	4.7	5.7	2.2	2.4	2.3	-2.1	2.0	-1.9
Patch foraging total patch changes 18 sec	1.0	1.6	3.0	1.7	1.5	1.1	-1.1	1.0	-0.9
Patch foraging total patch changes 24 sec	0.2	0.4	0.8	0.9	0.7	0.5	-0.5	0.4	-0.4
Patch foraging total patch changes 6 sec	2.3	3.5	6.4	2.5	2.0	2.1	-1.5	1.4	-1.3
Patch foraging time to switch 0 sec	7.7	15.8	20.1	-4.5	-4.2	-4.1	3.8	-3.7	3.6
Patch foraging water rate 0 sec	13.6	28.6	31.7	5.6	5.6	5.6	-5.2	5.1	-4.9
Patch foraging water rate 12 sec	7.7	16.1	18.9	3.5	4.0	4.4	-4.1	4.0	-4.1
Patch foraging water rate 18 sec	4.3	6.7	7.4	2.4	2.7	2.6	-2.7	2.5	-2.6
Patch foraging water rate 24 sec	4.2	5.8	7.2	2.0	2.4	2.7	-2.5	2.4	-2.4
Patch foraging water rate 6 sec	4.8	6.9	8.4	2.5	2.7	2.9	-2.6	2.5	-2.5
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.4	0.4	0.5	0.6	-0.6	0.6	-0.6
Distance traveled before self-admin	0.5	0.6	0.8	-0.9	-0.7	-0.7	0.7	-0.8	0.8
Distance traveled after self-admin	0.3	0.3	0.5	0.3	0.5	0.4	-0.6	0.6	-0.7
Extensor digitorum longus weight	7.3	28.8	35.1	5.9	5.4	5.2	-5.2	5.2	-5.1
Bone: elastic displacement	0.3	0.4	0.5	0.3	0.7	0.5	-0.7	0.7	-0.7
Bone: elastic work	0.1	0.1	0.2	-0.4	0.2	0.2	-0.3	0.3	-0.3
Bone: endosteal estimation	0.3	0.7	2.9	-1.7	-0.9	-0.7	0.4	-0.2	0.1
Bone: endosteal perimeter	0.1	0.2	0.8	-0.9	-0.5	-0.0	0.4	-0.3	0.3
Epididymis fat weight	2.9	10.0	11.7	-2.5	-3.3	-3.1	3.3	-3.4	3.3
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.2	0.0	0.2	-0.2	0.3	-0.3
Delta time in open arm before/after self-admin	0.5	0.5	1.5	1.2	0.8	0.4	-0.5	0.4	-0.4
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.5	0.0	-0.1	0.2	-0.3	0.3
Delay discount exponential model param	0.2	0.2	0.4	0.6	0.5	0.6	-0.3	0.3	-0.3
Extinction: sum of active levers before priming	0.5	0.6	1.0	0.2	-0.7	-0.7	0.9	-0.8	1.0
Active lever presses in extinction session 6	2.0	2.0	2.1	1.4	1.4	1.4	-1.4	1.5	-1.4
Bone: final force	0.1	0.2	0.3	-0.4	0.2	0.6	-0.4	0.5	-0.5
Bone: final moment	0.1	0.2	0.3	-0.2	0.3	0.6	-0.5	0.6	-0.6
Food consumed during 24 hour testing period	0.4	0.5	1.2	1.1	0.6	0.4	-0.6	0.6	-0.7
Glucose	0.3	0.5	1.0	0.7	0.9	1.0	-0.7	0.3	-0.5
Heart weight	0.5	0.8	0.9	0.9	1.0	0.9	-1.0	0.9	-0.9
Delay discount hyperbolic model param	0.2	0.2	0.4	0.7	0.4	0.6	-0.3	0.3	-0.3
Intermittent access intake day 1-15 change	1.7	3.5	3.8	-1.7	-1.9	-1.7	1.9	-1.9	1.9
Intermittent access intake escalation	1.7	3.4	3.8	-1.7	-1.9	-1.7	1.9	-1.9	1.9
Intermittent access intake escalation 2	1.3	1.5	2.0	-0.9	-1.2	-1.1	1.3	-1.3	1.4
Intermitt. access day 1 inactive lever presses	0.2	0.8	1.8	1.3	0.9	0.6	-0.8	0.8	-0.7
Intermitt. access day 15 inactive lever presses	1.3	2.6	4.9	2.2	1.6	1.2	-1.5	1.4	-1.5
Intermitt. access escalation Index	0.7	1.0	1.6	0.3	1.0	0.9	-1.2	1.2	-1.3
Intermittent access day 1 total infusions	0.3	0.4	0.6	-0.5	-0.6	-0.7	0.6	-0.8	0.6
Intermittent access day 15 total infusions	1.4	2.1	2.5	-1.3	-1.4	-1.4	1.5	-1.6	1.5
Intermittent access terminal intake (last 3 days)	2.0	2.6	3.5	-1.3	-1.6	-1.6	1.7	-1.9	1.7
Intermittent access total infusions	0.8	0.9	1.3	-0.7	-0.9	-0.9	1.0	-1.1	1.0
Intermittent access day 1 locomotion	1.5	1.9	2.3	-1.1	-1.4	-1.4	1.4	-1.5	1.4
Intermittent access day 15 total locomotion	0.4	0.7	1.5	-1.2	-0.7	-0.6	0.7	-0.8	0.7
Intermittent access total locomotion	0.8	1.0	1.5	-0.7	-0.9	-1.1	1.0	-1.2	1.0
Intermittent access standard deviation	1.4	2.9	3.9	-0.8	-1.7	-1.6	1.9	-2.0	1.9
Left kidney weight	1.7	7.8	8.8	2.9	2.7	2.5	-2.8	2.8	-3.0
Right kidney weight	1.4	6.2	7.0	2.5	2.4	2.3	-2.5	2.5	-2.7
Cocaine induced anxiety	1.5	2.2	2.9	1.2	1.5	1.7	-1.4	1.6	-1.3
Post-drug Anxiety	3.3	3.5	4.2	1.6	2.0	2.0	-1.9	2.0	-1.7
Baseline Anxiety	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.2	-0.3	0.2
Tail length	4.8	18.8	24.8	5.0	4.3	4.2	-4.2	4.2	-4.1
Length with tail	7.5	32.8	45.4	6.7	5.7	5.5	-5.5	5.4	-5.4
Length without tail	3.8	12.2	17.7	4.2	3.5	3.3	-3.3	3.3	-3.2
Times rat made contact with spout	0.2	0.3	1.1	1.0	0.4	0.6	-0.2	0.2	-0.1
Lifetime Intake	0.4	0.5	0.8	-0.6	-0.7	-0.6	0.7	-0.9	0.7
Liver weight, left	2.6	4.4	5.6	2.4	2.1	2.2	-2.0	1.9	-1.9
Liver weight, right	0.1	0.2	0.4	-0.3	-0.5	-0.6	0.5	-0.4	0.4
Locomotor activity	0.2	0.3	0.4	0.2	0.5	0.5	-0.6	0.6	-0.6
Locomotor testing distance	0.2	0.4	0.6	0.3	0.7	0.6	-0.7	0.8	-0.7
Locomotor testing rearing	1.6	3.2	4.5	-2.1	-1.8	-1.7	1.7	-1.6	1.8
Locomotion in novel chamber	3.9	5.0	5.6	1.9	2.2	2.4	-2.3	2.2	-2.3
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	-0.3	-0.2	-0.3	0.1	-0.0	-0.0
Fecal boli incidents, locomotor time 1	1.7	2.5	3.6	-0.8	-1.6	-1.9	1.7	-1.7	1.7
Change in fecal boli incidents, locomotor task	1.8	1.8	3.0	0.6	1.0	1.7	-1.4	1.4	-1.6
Time >=10cm from walls, locomotor time 1	0.1	0.2	0.4	0.7	-0.2	-0.0	0.4	-0.3	0.4
Bouts of movement, locomotor time 1	2.0	2.2	3.5	-1.0	-1.4	-1.9	1.5	-1.6	1.5
Total resting periods, locomotor time 1	1.9	2.2	3.2	-1.1	-1.4	-1.8	1.4	-1.5	1.5
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.5	-0.0	-0.2	0.1	-0.3	0.2
Distance moved, locomotor task time 1	0.1	0.1	0.5	-0.7	-0.5	0.2	0.3	-0.0	0.2
Vertical activity count, locomotor time 1	0.2	0.4	0.6	0.2	0.6	0.8	-0.7	0.8	-0.6
Time >=10cm from walls, locomotor time 2	0.4	0.6	2.1	1.5	0.8	0.4	-0.5	0.6	-0.4
Bouts of movement, locomotor time 2	1.0	1.6	2.2	0.7	1.3	1.2	-1.5	1.4	-1.5
Total resting periods, locomotor time 2	0.7	1.2	1.7	0.4	1.1	1.0	-1.3	1.2	-1.3
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.1	0.3	0.5	-0.3	0.2	-0.3
Distance moved, locomotor task time 2	0.2	0.2	0.3	-0.5	-0.5	-0.4	0.5	-0.3	0.5
Vertical activity count, locomotor time 2	0.1	0.2	0.3	0.6	0.5	0.2	-0.4	0.5	-0.3
Light reinforcement 1	0.0	0.0	0.1	-0.3	0.1	0.4	-0.1	0.0	-0.2
Light reinforcement 2	1.6	2.5	2.8	-1.5	-1.7	-1.3	1.7	-1.6	1.7
Bone: marrow area	0.3	0.7	2.7	-1.6	-0.8	-0.6	0.3	-0.2	0.1
Bone: maximum diameter	0.2	0.4	0.6	-0.5	-0.5	0.1	0.7	-0.8	0.8
Bone: maximum force	0.0	0.1	0.1	-0.1	0.1	0.4	-0.3	0.3	-0.3
Bone: maximum moment	0.0	0.1	0.1	0.1	0.1	0.3	-0.2	0.3	-0.3
Mean time between licks in bursts	0.2	0.6	1.6	-1.3	-0.9	-0.4	0.7	-0.5	0.5
Mean num. licks in bursts	0.3	0.4	1.7	1.3	0.5	0.4	-0.3	0.3	-0.3
Cd content in liver	0.2	0.2	0.4	0.2	0.2	0.2	-0.5	0.5	-0.6
Co content in liver	1.4	1.6	1.9	1.4	1.2	1.1	-1.3	1.4	-1.3
Cu content in liver	1.2	1.4	1.8	-1.4	-1.2	-0.8	1.2	-1.2	1.3
Fe content in liver	0.4	0.5	1.4	-1.2	-0.7	-0.4	0.6	-0.6	0.6
K content in liver	0.4	0.4	1.0	0.6	0.6	1.0	-0.5	0.5	-0.5
Mg content in liver	0.4	0.4	1.1	0.1	0.6	1.1	-0.6	0.6	-0.6
Mn content in liver	0.1	0.1	0.3	-0.5	-0.1	0.0	-0.1	0.1	-0.2
Na content in liver	0.6	0.7	1.2	-0.7	-0.7	-0.1	0.9	-1.0	1.1
Rb content in liver	0.9	1.1	1.5	0.3	1.0	1.1	-1.1	1.2	-1.2
Se content in liver	0.1	0.1	0.3	-0.6	-0.4	0.0	0.3	-0.3	0.2
Sr content in liver	0.2	0.2	0.2	0.2	0.3	0.4	-0.4	0.4	-0.5
Zn content in liver	1.0	1.1	1.9	0.9	1.0	1.4	-1.0	1.0	-1.0
Bone: minimum diameter	0.7	1.2	1.5	0.8	1.0	1.2	-1.1	1.2	-1.2
Time in familiar zone, hab. session 1	0.0	0.0	0.2	-0.1	-0.2	-0.5	0.1	0.0	-0.0
Time in novel zone, hab. session 1	0.5	0.5	1.4	-1.2	-0.6	-0.5	0.5	-0.6	0.5
Total zone transitions, hab. session 1	0.3	0.4	1.4	-1.2	-0.7	-0.6	0.3	-0.2	0.1
Total locomotion distance, hab. session 1	0.5	0.6	1.3	-0.2	0.6	0.6	-0.9	1.0	-1.1
Locomotion velocity, hab. session 1	0.9	1.3	1.8	0.4	1.1	1.2	-1.2	1.3	-1.4
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.1	-0.3	-0.3	0.4	-0.2	0.4
Time in novel zone, hab. session 2	0.2	0.2	0.6	-0.8	-0.4	-0.3	0.3	-0.4	0.2
Total zone transitions, hab. session 2	0.6	0.8	1.0	-0.4	-0.9	-0.9	1.0	-1.0	0.9
Total locomotion distance, hab. session 2	0.4	0.5	0.6	0.6	0.7	0.8	-0.7	0.6	-0.7
Locomotion velocity, hab. session 2	0.5	0.7	0.9	0.8	0.9	1.0	-0.8	0.7	-0.8
Novel to familiar place preference ratio	0.8	0.8	1.3	-1.0	-0.8	-1.1	0.8	-0.9	0.8
Novelty place preference	0.5	0.6	0.9	-0.9	-0.6	-0.9	0.6	-0.7	0.6
Time in novel zone, NPP test	0.3	0.4	0.8	-0.7	-0.5	-0.9	0.5	-0.5	0.5
Total zone transitions, NPP test	0.1	0.1	0.2	0.4	0.2	-0.3	-0.3	0.3	-0.4
Total locomotion distance, NPP test	0.2	0.3	0.5	0.3	0.5	0.2	-0.6	0.6	-0.7
Locomotion velocity, NPP test	0.2	0.3	0.5	0.4	0.5	0.3	-0.6	0.5	-0.7
Intraocular pressure	0.1	0.1	0.3	-0.3	-0.1	-0.5	-0.1	0.2	-0.1
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.2	0.1	0.1	-0.3	0.3	-0.4
Delta ambulatory time before/after self-admin	0.9	1.1	1.5	0.9	0.9	0.9	-1.1	1.1	-1.2
Parametrial fat weight	0.2	0.4	0.5	-0.5	-0.7	-0.7	0.6	-0.6	0.5
Pavlov. Cond. lever latency	0.7	0.9	1.4	0.4	0.9	1.0	-1.1	1.2	-1.1
Pavlov. Cond. magazine entry latency	0.4	0.5	1.1	0.0	-0.7	-1.0	0.8	-0.7	0.8
Pavlov. Cond. change in total contacts	0.3	0.3	0.5	0.1	-0.4	-0.6	0.6	-0.7	0.7
Pavlov. Cond. index score	0.9	1.2	1.7	-0.2	-1.0	-1.3	1.2	-1.2	1.2
Pavlov. Cond. latency score	0.7	0.9	1.2	-0.1	-0.8	-1.1	1.0	-1.1	1.1
Pavlov. Cond. lever contacts	1.4	1.7	2.3	-0.7	-1.2	-1.3	1.4	-1.5	1.5
Pavlov. Cond. magazine entry number	0.7	0.8	1.4	0.0	0.9	1.2	-1.0	1.0	-1.0
Pavlov. Cond. intertrial magazine entries	6.4	7.6	9.3	3.1	2.8	2.8	-2.7	2.7	-2.6
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.4	-0.2	-0.9	-1.2	1.1	-1.2	1.2
Pavlov. Cond. response bias	1.2	1.5	2.1	-0.2	-1.2	-1.5	1.3	-1.4	1.3
Pavlov. Cond. lever latency	1.7	2.3	4.2	2.1	1.7	1.4	-1.4	1.3	-1.1
Pavlov. Cond. magazine entry latency	3.6	4.3	5.0	-2.2	-2.2	-2.2	2.0	-2.0	1.9
Pavlov. Cond. change in total contacts	3.4	5.4	7.3	-2.7	-2.5	-2.3	2.2	-2.1	2.1
Pavlov. Cond. index score	3.6	4.8	6.5	-2.5	-2.4	-2.3	2.1	-1.9	1.8
Pavlov. Cond. latency score	3.8	5.0	6.3	-2.5	-2.4	-2.3	2.2	-2.0	1.9
Pavlov. Cond. lever contacts	2.3	3.2	5.1	-2.3	-2.0	-1.7	1.7	-1.6	1.4
Pavlov. Cond. magazine entry number	3.0	3.7	4.4	2.1	2.1	2.0	-1.9	1.8	-1.7
Pavlov. Cond. intertrial magazine entries	4.5	6.8	7.6	2.6	2.8	2.7	-2.6	2.5	-2.5
Pavlov. Cond. lever-magazine prob. diff.	4.1	5.5	7.4	-2.7	-2.6	-2.4	2.2	-2.1	2.0
Pavlov. Cond. response bias	2.5	3.4	4.9	-2.2	-2.1	-1.9	1.7	-1.6	1.4
Time in closed arm before self-admin	3.9	5.0	7.7	-2.8	-2.2	-2.1	2.1	-2.1	2.1
Time in closed arm after self-admin	1.7	1.8	5.5	-2.4	-1.3	-0.9	1.0	-0.9	0.9
Time in open arm before self-admin	4.3	4.7	4.9	2.1	2.1	2.2	-2.2	2.2	-2.2
Time in open arm after self-admin	3.6	3.9	8.5	2.9	2.0	1.6	-1.7	1.7	-1.6
Bone: periosteal estimation	0.0	0.1	0.3	-0.5	-0.1	0.3	-0.2	0.2	-0.3
Bone: periosteal perimeter	0.0	0.1	0.1	-0.4	-0.2	0.2	0.2	-0.3	0.2
Bone: post-yield work	2.0	2.9	3.6	1.7	1.6	1.3	-1.7	1.9	-1.8
Progressive ratio test 1 active lever presses	0.3	0.3	0.5	-0.7	-0.5	-0.6	0.5	-0.7	0.5
Progressive ratio test 1 breakpoint	0.4	0.5	0.7	-0.8	-0.6	-0.7	0.6	-0.8	0.6
Progressive ratio test 1 inactive lever presses	1.6	2.3	2.7	1.7	1.5	1.4	-1.5	1.4	-1.5
Progressive ratio test 2 active lever presses	0.1	0.1	0.5	-0.7	-0.0	0.2	0.0	-0.2	0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.4	-0.7	-0.0	0.2	-0.0	-0.1	0.0
Progressive ratio test 2 inactive lever presses	0.3	0.5	0.8	0.3	0.8	0.7	-0.9	0.8	-0.8
Incentive Sensitization - Responses	0.1	0.1	0.3	-0.5	0.1	0.3	-0.1	0.1	-0.1
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	-0.5	0.2	0.4	-0.2	0.2	-0.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.5	0.7	0.3	0.3	-0.0	-0.0	0.1
Progressive ratio	0.2	0.3	0.9	-0.9	-0.0	0.9	-0.3	0.3	-0.3
Food seeking constrained by brief footshock	0.6	0.7	1.1	1.0	1.0	0.5	-1.0	0.7	-0.8
Seeking ratio, punishment vs. effort	0.3	0.4	1.7	1.3	0.5	-0.6	-0.2	0.2	-0.1
Retroperitoneal fat weight	0.1	0.4	0.6	-0.2	-0.7	-0.6	0.7	-0.8	0.7
Reaction time number correct	2.6	5.0	5.9	2.3	2.4	2.2	-2.2	2.1	-2.1
Reaction time mean minus median	0.0	0.1	0.4	-0.2	-0.2	-0.6	0.1	-0.2	0.0
Reaction time mean minus median AUC	0.0	0.1	0.3	-0.2	-0.1	-0.6	-0.0	-0.1	-0.1
Reaction time num false alarms	1.2	1.7	2.9	1.7	1.3	1.4	-1.2	1.0	-1.1
Reaction time num false alarms AUC	1.4	2.1	2.7	1.7	1.6	1.6	-1.4	1.2	-1.3
Reaction time trials correct on left	2.6	5.0	5.9	2.3	2.4	2.2	-2.2	2.1	-2.1
Reaction time trials on left	2.7	5.1	5.9	2.3	2.4	2.2	-2.3	2.2	-2.1
Reaction time mean	0.6	1.0	1.8	-1.3	-1.1	-1.2	0.8	-0.8	0.6
Reaction time mean AUC	0.3	0.5	1.1	-1.0	-0.8	-1.0	0.5	-0.5	0.3
Median of all reaction times	0.4	0.6	1.5	-1.2	-0.8	-0.8	0.5	-0.4	0.3
Reaction time omissions	0.6	0.9	1.7	0.5	1.0	0.4	-1.2	1.0	-1.3
Reaction time false alarm rate	0.1	0.1	0.3	0.5	0.3	0.5	-0.3	0.2	-0.3
Reaction time premature initiation rate	0.8	1.1	1.4	0.8	1.0	1.1	-1.1	1.2	-1.0
Reaction time premature initiations	2.2	4.0	4.4	2.0	2.1	2.0	-2.0	2.1	-1.9
Std. dev. reaction times	0.2	0.4	0.9	-1.0	-0.6	-0.9	0.4	-0.5	0.2
Reaction time trials completed	2.7	5.1	5.9	2.3	2.4	2.2	-2.3	2.2	-2.1
Reaction time trials AUC	2.8	5.4	6.3	2.4	2.5	2.3	-2.3	2.2	-2.2
Run reversals in cocaine runway, females	0.8	0.8	1.1	-1.0	-0.9	-1.0	0.8	-0.9	0.8
Run reversals in cocaine runway, males	0.2	0.2	0.3	0.0	0.5	0.5	-0.5	0.5	-0.4
Latency to leave start box in cocaine runway	0.4	0.4	0.8	-0.9	-0.6	-0.3	0.6	-0.7	0.7
Latency to leave start box in cocaine runway, F	0.4	0.5	0.7	-0.8	-0.5	-0.5	0.7	-0.7	0.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.4	-0.3	0.0	0.3	-0.5	0.3
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.3	-0.3	-0.3	0.1	0.0	-0.2
Total sessions with >9 infusions	0.3	0.4	0.8	-0.9	-0.6	-0.3	0.5	-0.7	0.4
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.2	0.1	0.2	-0.2	0.2	-0.3
Short access day 10 total inactive lever presses	0.0	0.1	0.2	0.4	0.2	-0.0	-0.3	0.3	-0.4
Short access day 1 total infusions	0.1	0.2	0.4	0.1	0.3	0.6	-0.4	0.3	-0.4
Short access day 10 total infusions	0.7	0.9	1.4	-0.9	-0.9	-0.8	0.9	-1.2	0.9
Short access total infusions	0.3	0.4	1.1	-1.0	-0.6	-0.3	0.5	-0.7	0.5
Short access day 1 locomotion	0.4	0.4	0.9	-1.0	-0.7	-0.4	0.6	-0.6	0.6
Short access day 10 total locomotion	1.5	2.7	3.8	-0.9	-1.6	-1.9	1.7	-2.0	1.7
Short access total locomotion	0.4	0.5	0.8	-0.7	-0.6	-0.7	0.7	-0.9	0.7
One hour access (0.3 mA shock)	0.0	0.0	0.2	0.4	0.2	0.1	0.0	-0.1	0.1
Compulsive drug intake	0.2	0.3	1.0	1.0	0.4	0.2	-0.3	0.5	-0.3
One hour access (shock baseline)	0.0	0.0	0.0	0.0	0.0	0.2	0.0	-0.2	0.1
Social response proportion	0.3	0.4	0.9	-0.6	0.3	1.0	-0.5	0.6	-0.6
Social responses	0.1	0.1	0.4	-0.6	-0.2	0.0	0.0	-0.1	-0.0
Social time	1.5	2.1	3.3	0.3	1.2	1.4	-1.6	1.8	-1.8
Soleus weight	0.2	0.5	2.4	1.5	0.5	0.3	-0.4	0.4	-0.5
Bone: stiffness	0.8	1.3	1.8	0.9	1.1	1.3	-1.1	1.2	-1.2
Tibialis anterior weight	0.3	1.1	2.3	1.5	1.0	1.0	-0.9	0.9	-0.8
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.2	1.1	0.7	0.6	-0.6	0.6	-0.6
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	-0.3	-0.5	-0.3	0.6	-0.6	0.6
Time to tail flick, test, before self-admin	0.1	0.1	0.5	-0.7	-0.3	-0.4	0.2	-0.2	0.2
Time to tail flick, test, after self-admin	0.9	1.0	1.1	1.0	1.0	1.1	-0.9	0.9	-0.9
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.0	-0.1	-0.1	0.2	-0.2	0.2
Delta time to tail flick, test, before/after SA	1.4	1.4	1.9	1.4	1.1	1.3	-1.1	1.1	-1.1
Tibia length	0.1	0.3	0.5	0.7	0.7	0.6	-0.6	0.4	-0.4
Ambulatory time before self-admin	0.8	1.1	1.3	-1.1	-1.0	-1.0	1.1	-1.1	1.1
Ambulatory time after self-admin	0.1	0.1	0.1	-0.3	-0.2	-0.4	0.2	-0.2	0.1
Bone: tissue strength	0.0	0.0	0.0	0.1	0.1	-0.1	0.0	-0.1	0.1
Total heroin consumption	1.9	2.2	5.0	2.2	1.6	1.4	-1.2	1.1	-1.0
Bone: trabecular number	0.1	0.2	0.3	0.6	0.4	-0.0	-0.4	0.4	-0.5
Bone: trabecular spacing	0.1	0.1	0.1	-0.3	-0.3	0.0	0.3	-0.3	0.3
Bone: trabecular thickness	0.0	0.0	0.1	0.1	-0.2	-0.3	0.2	-0.2	0.2
Bone: trabecular tissue density	0.1	0.1	0.3	-0.0	-0.1	0.1	0.3	-0.4	0.5
Water consumed over 24 hours	1.9	2.6	3.6	1.4	1.7	1.9	-1.6	1.5	-1.5
Number of responses in last shaping day	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.1	-0.1	-0.1