LOC120103531

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC120103531	0.09	0.05	2.0e-12	0.08	0.11	0.11	0.11	3.7e-09	3.7e-12	1.8e-12	6.5e-12
2	Brain	gene expression	LOC120103531	0.31	0.13	0.0e+00	0.29	0.31	0.3	0.3	1.8e-27	6.1e-29	7.3e-29	1.3e-28
3	IL	gene expression	LOC120103531	0.22	0.12	1.9e-04	0.15	0.17	0.14	0.16	1.6e-04	5.7e-05	2.7e-04	1.1e-04
4	NAcc	gene expression	LOC120103531	0.08	0.05	3.9e-14	0.08	0.1	0.09	0.09	6.4e-12	1.6e-14	1.1e-13	6.0e-14
5	BLA	gene expression	LOC120103531	0.05	0.04	4.4e-03	0.05	0.02	0.03	0.02	8.7e-04	2.4e-02	9.3e-03	2.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	5.9	10.9	12.8	3.1	-3.5	-3.5	-2.8	3.6
Area under the delay curve	0.4	0.6	0.8	-0.7	0.9	0.9	0.6	-0.9
BMI with tail	0.5	1.9	2.6	0.9	-1.5	-1.6	-1.1	1.6
BMI without tail	1.8	9.6	10.7	2.8	-3.2	-3.3	-3.0	3.2
Body weight	3.2	14.0	15.2	3.6	-3.8	-3.9	-3.6	3.8
Weight adjusted by age	0.0	0.1	0.4	-0.6	0.4	0.4	0.0	0.2
Bone surface	5.2	10.2	11.0	3.3	-3.3	-3.2	-2.9	3.2
Bone volume	6.2	12.4	13.0	3.6	-3.6	-3.6	-3.2	3.6
Breakpoint value in progressive ratio session	2.7	4.9	5.5	2.2	-2.2	-2.2	-2.1	2.3
Number of licking bursts	0.2	0.6	0.7	-0.8	0.8	0.8	0.8	-0.8
Context. condit. distance diff. score	1.0	1.2	1.8	0.7	-1.1	-1.1	-1.3	1.1
Locomotion velocity, session 1	0.4	0.4	0.5	0.7	-0.6	-0.6	-0.7	0.7
Locomotion distance, session 1	0.7	0.9	1.2	-1.1	1.0	1.1	0.9	-0.7
Locomotion velocity, session 2	1.5	1.8	2.3	-1.2	1.4	1.5	1.3	-1.3
Locomotion distance, session 2	2.1	2.9	3.3	-1.7	1.7	1.8	1.8	-1.5
Locomotion velocity, session 3	0.7	0.8	1.1	-0.7	1.0	1.1	0.9	-0.9
Locomotion distance, session 3	0.3	0.4	0.7	-0.7	0.6	0.6	0.8	-0.5
Stereotopy head waving bouts, day 3	2.0	2.3	2.7	-1.5	1.6	1.6	1.3	-1.5
Stereotopy head waving duration, day 3	1.1	1.4	1.6	-1.1	1.2	1.3	1.0	-1.2
Locomotion velocity, session 7	0.5	0.6	1.2	-1.1	0.4	0.4	1.1	-0.2
Locomotion distance, session 7	0.5	0.7	1.3	-1.0	0.6	0.5	1.1	-0.6
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.5	-0.2	-0.2	-0.4	0.3
Stereotopy head waving duration, day 7	0.1	0.1	0.1	-0.1	0.3	0.4	0.2	-0.2
Locomotion velocity, session 8	0.1	0.1	0.2	0.4	-0.2	-0.2	-0.4	0.3
Locomotion distance, session 8	0.1	0.1	0.3	0.1	-0.4	-0.3	-0.4	0.5
Degree of sensitization distance	0.0	0.0	0.1	0.1	-0.3	-0.3	-0.0	0.2
Degree of sensitization stereotypy	1.7	1.8	2.4	1.6	-1.3	-1.2	-1.4	1.3
Conditioned locomotion	0.3	0.3	0.6	-0.2	0.7	0.7	0.2	-0.8
Cocaine response after cond. corrected	0.3	0.5	0.8	-0.9	0.6	0.6	0.7	-0.7
Cocaine response after cond. not corrected	0.2	0.3	0.5	-0.7	0.4	0.4	0.6	-0.5
Cocaine response before conditioning	0.0	0.0	0.1	-0.1	0.2	0.2	0.3	-0.2
Saline control response	1.0	1.3	1.5	1.1	-1.2	-1.2	-1.2	1.1
Bone: connectivity density	8.9	14.2	16.6	3.5	-4.0	-4.0	-3.2	4.1
Bone: cortical apparent density	0.5	0.8	1.5	-1.2	0.8	0.7	1.0	-0.8
Bone: cortical area	2.5	4.0	5.3	2.3	-1.9	-1.9	-2.0	1.9
Bone: cortical porosity	0.3	0.3	0.4	0.6	-0.5	-0.4	-0.6	0.5
Bone: cortical porosity	0.4	0.5	0.7	0.9	-0.6	-0.5	-0.8	0.6
Bone: cortical thickness	0.3	0.4	0.5	0.6	-0.7	-0.7	-0.6	0.7
Bone: cortical thickness	0.1	0.2	0.4	-0.6	0.3	0.3	0.3	-0.2
Bone: cortical tissue density	0.6	0.9	1.6	-1.3	0.8	0.8	1.0	-0.8
Condit. Reinf. active minus inactive responses	0.8	0.9	1.5	1.2	-0.9	-0.8	-1.0	0.9
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.5	-0.5	-0.5	-0.6	0.6
Condit. Reinf. active responses	0.8	1.0	2.0	1.4	-0.8	-0.7	-1.0	0.8
Condit. Reinf. inactive responses	0.1	0.1	0.4	0.6	-0.0	0.0	-0.1	0.0
Incentive salience index mean	0.9	1.2	2.3	1.5	-1.0	-0.9	-0.9	1.0
Condit. Reinf. lever presses	0.1	0.2	0.5	0.7	-0.4	-0.3	-0.0	0.4
Condit. Reinf. active minus inactive responses	0.6	0.9	1.1	-0.6	1.0	1.0	1.0	-1.0
Condit. Reinf. active-inactive response ratio	0.5	0.8	0.9	-0.8	1.0	0.9	0.9	-0.9
Condit. Reinf. active responses	0.4	0.6	0.9	-0.3	0.8	0.8	1.0	-0.7
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.4	-0.3	-0.3	0.0	0.4
Condit. Reinf. lever presses	1.9	2.8	4.2	2.0	-1.6	-1.6	-1.5	1.6
Condit. Reinf. lever reinforcers received	0.1	0.1	0.5	0.7	-0.1	-0.1	0.0	0.1
Conditioned reinforcement - actives	0.6	2.3	3.0	1.5	-1.4	-1.3	-1.7	1.7
Conditioned reinforcement - inactives	1.1	3.1	3.5	1.7	-1.7	-1.7	-1.9	1.9
Conditioned locomotion	1.0	1.4	1.8	1.1	-1.2	-1.1	-1.2	1.3
Patch foraging indifference point 0 sec	0.4	1.2	1.9	1.4	-0.9	-0.8	-1.0	1.2
Patch foraging indifference point AUC	0.2	0.5	1.0	1.0	-0.3	-0.3	-0.6	1.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.1	0.4	0.3	0.1	-0.3
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.3	0.1	0.1	-0.1	-0.1
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	0.6	-0.3	-0.3	-0.5	0.3
Delay disc. indifference point, 24s delay	0.2	0.3	0.5	-0.2	0.7	0.7	0.3	-0.7
Delay disc. indifference point, 4s delay	2.7	2.9	3.4	-1.8	1.7	1.7	1.5	-1.7
Delay disc. indifference point, 8s delay	0.1	0.2	0.3	-0.4	0.5	0.5	0.4	-0.4
Indifference point function ln k	0.0	0.0	0.1	-0.1	-0.3	-0.3	-0.1	-0.0
Indifference point function log k	0.0	0.0	0.1	-0.1	-0.3	-0.3	-0.1	-0.0
Patch foraging total patch changes 0 sec	0.4	1.2	2.0	1.4	-0.9	-0.8	-1.1	1.2
Patch foraging total patch changes 12 sec	1.2	1.7	2.8	1.7	-1.0	-0.9	-1.2	1.5
Patch foraging total patch changes 18 sec	0.0	0.1	0.3	0.2	0.1	0.1	0.0	0.6
Patch foraging total patch changes 24 sec	0.9	3.0	4.7	2.0	-1.4	-1.4	-1.6	2.2
Patch foraging total patch changes 6 sec	1.3	2.3	3.1	1.8	-1.3	-1.2	-1.5	1.6
Patch foraging time to switch 0 sec	1.0	3.8	7.9	-2.8	1.5	1.5	1.8	-1.7
Patch foraging water rate 0 sec	0.6	2.3	4.5	2.1	-1.3	-1.3	-1.4	1.4
Patch foraging water rate 12 sec	2.0	8.0	9.1	3.0	-2.9	-2.9	-2.8	2.6
Patch foraging water rate 18 sec	1.6	3.5	4.1	2.0	-1.9	-1.9	-1.9	1.5
Patch foraging water rate 24 sec	3.4	4.8	5.0	2.2	-2.2	-2.2	-2.1	2.2
Patch foraging water rate 6 sec	3.1	4.6	7.1	2.7	-2.0	-2.0	-2.1	2.0
Seeking ratio, delayed vs. immediate footshock	2.3	3.3	4.4	-1.8	1.7	1.7	2.1	-1.7
Distance traveled before self-admin	0.0	0.1	0.1	0.4	0.2	0.2	-0.2	0.1
Distance traveled after self-admin	0.0	0.1	0.2	0.2	-0.2	-0.2	-0.1	0.4
Extensor digitorum longus weight	4.7	18.6	20.2	4.5	-4.3	-4.4	-4.4	3.9
Bone: elastic displacement	0.0	0.0	0.1	-0.3	0.0	0.0	0.0	0.1
Bone: elastic work	1.7	2.3	2.9	1.3	-1.6	-1.6	-1.3	1.7
Bone: endosteal estimation	1.0	2.4	3.8	1.9	-1.4	-1.3	-1.8	1.3
Bone: endosteal perimeter	0.7	1.6	3.3	1.8	-1.0	-1.0	-1.4	1.0
Epididymis fat weight	0.1	0.6	1.1	0.3	-0.9	-0.9	-0.5	1.1
Delta time in closed arm before/after self-admin	2.6	2.4	2.7	1.6	-1.6	-1.6	-1.6	1.2
Delta time in open arm before/after self-admin	0.2	0.2	0.6	0.4	-0.3	-0.3	-0.4	0.8
Diff in mean of infusions in LGA sessions	0.2	0.4	0.7	-0.6	0.7	0.7	0.8	-0.1
Delay discount exponential model param	1.0	1.3	1.5	1.0	-1.2	-1.2	-1.0	1.2
Extinction: sum of active levers before priming	3.4	5.1	6.4	2.2	-2.5	-2.5	-2.0	2.1
Active lever presses in extinction session 6	6.9	6.9	7.8	2.8	-2.6	-2.5	-2.8	2.4
Bone: final force	2.1	3.4	3.7	1.8	-1.9	-1.9	-1.9	1.8
Bone: final moment	2.6	4.2	4.8	2.1	-2.1	-2.1	-2.2	1.9
Food consumed during 24 hour testing period	0.1	0.2	0.4	0.6	-0.3	-0.3	-0.4	0.2
Glucose	1.4	2.3	2.5	1.5	-1.5	-1.5	-1.6	1.5
Heart weight	3.4	5.5	6.7	2.6	-2.3	-2.2	-2.3	2.4
Delay discount hyperbolic model param	0.9	1.2	1.5	0.9	-1.2	-1.2	-0.9	1.2
Intermittent access intake day 1-15 change	0.6	3.1	3.9	1.5	-2.0	-1.9	-1.7	1.6
Intermittent access intake escalation	0.4	2.4	3.0	1.3	-1.7	-1.7	-1.5	1.4
Intermittent access intake escalation 2	1.5	2.5	3.1	1.4	-1.8	-1.7	-1.6	1.4
Intermitt. access day 1 inactive lever presses	0.0	0.5	0.8	-0.7	0.5	0.5	0.9	-0.8
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	0.1	0.0	-0.1	0.3	-0.2
Intermitt. access escalation Index	0.0	0.1	0.1	-0.2	0.3	0.3	0.3	-0.3
Intermittent access day 1 total infusions	0.1	0.4	0.6	-0.3	0.8	0.8	0.7	-0.4
Intermittent access day 15 total infusions	0.5	1.3	1.4	1.2	-1.1	-1.1	-1.1	1.1
Intermittent access terminal intake (last 3 days)	1.4	2.4	2.8	1.7	-1.5	-1.4	-1.7	1.6
Intermittent access total infusions	0.6	0.7	1.0	0.9	-0.7	-0.7	-0.8	1.0
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.4	0.1	0.1	0.2	0.2
Intermittent access day 15 total locomotion	0.2	0.8	1.1	0.6	-1.0	-1.0	-0.7	1.0
Intermittent access total locomotion	0.5	0.6	0.7	0.7	-0.8	-0.8	-0.6	0.8
Intermittent access standard deviation	0.3	1.8	2.0	1.3	-1.4	-1.4	-1.4	1.2
Left kidney weight	1.1	8.8	9.9	2.8	-3.1	-3.1	-2.8	3.1
Right kidney weight	0.8	5.7	6.4	2.2	-2.4	-2.5	-2.3	2.5
Cocaine induced anxiety	0.9	2.5	3.0	-1.3	1.7	1.7	1.6	-1.5
Post-drug Anxiety	0.8	0.9	1.2	-0.6	1.0	0.9	1.0	-1.1
Baseline Anxiety	1.6	2.6	3.1	1.5	-1.7	-1.8	-1.6	1.6
Tail length	2.3	12.2	14.5	3.8	-3.4	-3.5	-3.5	3.3
Length with tail	3.6	15.8	18.8	4.3	-3.9	-3.9	-4.0	3.8
Length without tail	0.5	2.6	3.0	1.7	-1.5	-1.5	-1.7	1.6
Times rat made contact with spout	0.8	0.9	1.7	-1.3	0.8	0.7	1.0	-0.8
Lifetime Intake	1.2	1.5	1.9	1.3	-1.2	-1.1	-1.2	1.4
Liver weight, left	1.7	3.0	4.0	1.2	-1.8	-1.8	-1.6	2.0
Liver weight, right	0.1	0.1	0.2	-0.5	-0.4	-0.4	-0.1	0.4
Locomotor activity	9.2	14.3	20.2	4.5	-3.7	-3.7	-3.9	3.0
Locomotor testing distance	4.0	9.8	13.5	3.7	-3.1	-3.0	-3.2	2.6
Locomotor testing rearing	2.8	10.1	12.5	3.5	-3.1	-3.0	-3.2	3.0
Locomotion in novel chamber	0.0	0.1	0.2	-0.1	0.0	0.1	-0.1	-0.5
Locomotion in novel chamber post-restriction	0.6	1.9	2.6	-1.1	1.5	1.5	1.6	-1.0
Fecal boli incidents, locomotor time 1	1.2	3.1	4.0	2.0	-1.7	-1.7	-1.9	1.4
Change in fecal boli incidents, locomotor task	0.5	0.6	0.9	-1.0	0.7	0.6	0.8	-0.6
Time >=10cm from walls, locomotor time 1	0.9	1.1	1.2	1.1	-1.0	-1.0	-0.9	1.1
Bouts of movement, locomotor time 1	0.3	0.3	0.6	-0.2	0.8	0.7	0.2	-0.7
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.0	0.6	0.5	-0.0	-0.5
Rest time, locomotor task time 1	0.3	0.5	0.8	-0.2	0.8	0.8	0.2	-0.9
Distance moved, locomotor task time 1	0.3	0.8	1.3	0.4	-1.1	-1.1	-0.5	1.1
Vertical activity count, locomotor time 1	0.2	1.4	1.8	0.7	-1.4	-1.3	-1.0	1.4
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.2	-0.1	-0.1	0.1	0.1
Bouts of movement, locomotor time 2	0.1	0.3	0.5	-0.7	0.4	0.5	0.5	-0.5
Total resting periods, locomotor time 2	0.2	0.8	1.3	-1.1	0.8	0.8	0.8	-0.8
Rest time, locomotor task time 2	0.2	0.3	0.4	-0.5	0.6	0.6	0.2	-0.6
Distance moved, locomotor task time 2	0.7	0.9	1.3	1.0	-0.9	-0.9	-0.8	1.1
Vertical activity count, locomotor time 2	0.3	0.6	0.9	0.6	-0.8	-0.8	-0.6	0.9
Light reinforcement 1	0.1	0.6	0.9	0.7	-0.9	-0.8	-0.9	0.5
Light reinforcement 2	1.4	3.1	3.8	-1.6	1.7	1.8	1.8	-1.9
Bone: marrow area	1.1	2.7	4.2	2.0	-1.4	-1.4	-1.9	1.4
Bone: maximum diameter	2.2	4.4	7.5	2.7	-1.8	-1.8	-2.2	1.7
Bone: maximum force	1.8	3.7	4.3	2.1	-1.8	-1.8	-2.0	1.8
Bone: maximum moment	2.2	4.2	5.1	2.3	-1.9	-1.9	-2.2	1.9
Mean time between licks in bursts	0.2	1.1	1.6	0.9	-1.0	-1.0	-1.3	1.0
Mean num. licks in bursts	0.1	0.3	0.4	0.3	-0.6	-0.6	-0.4	0.5
Cd content in liver	0.7	0.8	1.0	0.7	-0.9	-1.0	-0.9	1.0
Co content in liver	3.8	4.4	4.9	2.2	-2.1	-2.1	-2.2	1.9
Cu content in liver	0.0	0.0	0.1	-0.3	0.0	0.0	0.0	-0.1
Fe content in liver	0.0	0.0	0.1	0.0	0.2	0.2	-0.2	-0.3
K content in liver	4.0	3.9	4.2	-2.0	2.0	2.0	2.0	-1.8
Mg content in liver	3.2	3.5	4.0	-2.0	1.9	1.9	1.9	-1.6
Mn content in liver	2.6	2.9	3.2	-1.6	1.8	1.8	1.7	-1.6
Na content in liver	4.6	5.2	6.2	-2.5	2.2	2.2	2.5	-2.0
Rb content in liver	0.4	0.5	1.0	-1.0	0.6	0.7	0.6	-0.5
Se content in liver	3.5	4.1	4.7	-2.0	2.1	2.2	2.0	-1.9
Sr content in liver	2.3	2.0	2.5	1.3	-1.5	-1.6	-1.0	1.5
Zn content in liver	0.5	0.5	0.7	-0.5	0.8	0.8	0.7	-0.8
Bone: minimum diameter	1.7	3.3	4.9	2.2	-1.7	-1.6	-2.0	1.6
Time in familiar zone, hab. session 1	1.9	2.1	2.3	1.3	-1.5	-1.4	-1.5	1.5
Time in novel zone, hab. session 1	0.3	0.3	0.4	-0.5	0.5	0.5	0.6	-0.6
Total zone transitions, hab. session 1	1.9	2.6	3.0	-1.4	1.7	1.7	1.7	-1.6
Total locomotion distance, hab. session 1	2.4	3.5	3.6	-1.8	1.9	1.9	1.9	-1.9
Locomotion velocity, hab. session 1	3.7	5.2	5.8	-2.0	2.4	2.4	2.2	-2.4
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.1	-0.4	-0.5	-0.3	0.3
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.4	0.1	0.1	-0.2	-0.0
Total zone transitions, hab. session 2	2.2	2.8	3.5	-1.5	1.7	1.8	1.9	-1.5
Total locomotion distance, hab. session 2	2.9	3.8	4.3	-1.7	2.0	2.1	2.0	-1.9
Locomotion velocity, hab. session 2	2.9	3.8	4.3	-1.7	2.1	2.1	2.0	-1.9
Novel to familiar place preference ratio	0.1	0.1	0.4	0.6	-0.3	-0.3	-0.2	0.3
Novelty place preference	0.3	0.3	0.9	0.9	-0.5	-0.5	-0.5	0.4
Time in novel zone, NPP test	0.3	0.4	0.9	0.9	-0.6	-0.6	-0.6	0.5
Total zone transitions, NPP test	0.7	1.0	1.6	-0.9	1.0	1.0	1.3	-0.8
Total locomotion distance, NPP test	1.1	1.5	1.9	-1.1	1.3	1.3	1.4	-1.1
Locomotion velocity, NPP test	0.9	1.3	1.7	-1.0	1.2	1.2	1.3	-1.0
Intraocular pressure	0.1	0.1	0.4	0.4	-0.3	-0.2	-0.6	0.1
Delta distance traveled before/after self-admin	0.4	0.5	0.9	-0.9	0.5	0.5	0.8	-0.4
Delta ambulatory time before/after self-admin	0.5	0.9	1.5	-1.2	0.8	0.8	1.0	-0.8
Parametrial fat weight	3.3	7.7	8.7	2.6	-2.9	-2.9	-2.8	2.7
Pavlov. Cond. lever latency	0.2	0.3	0.7	0.3	-0.5	-0.5	-0.8	0.5
Pavlov. Cond. magazine entry latency	5.4	6.9	8.5	-2.5	2.6	2.6	2.9	-2.6
Pavlov. Cond. change in total contacts	1.8	1.9	2.2	-1.2	1.4	1.5	1.5	-1.4
Pavlov. Cond. index score	2.9	3.7	5.0	-1.7	1.9	1.9	2.2	-1.9
Pavlov. Cond. latency score	2.1	2.6	3.7	-1.4	1.6	1.6	1.9	-1.6
Pavlov. Cond. lever contacts	0.2	0.3	0.7	-0.3	0.4	0.5	0.8	-0.4
Pavlov. Cond. magazine entry number	5.7	7.2	9.0	2.5	-2.6	-2.6	-3.0	2.6
Pavlov. Cond. intertrial magazine entries	2.2	2.6	3.6	1.3	-1.6	-1.5	-1.9	1.7
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.8	5.1	-1.8	1.9	1.9	2.3	-1.9
Pavlov. Cond. response bias	3.6	4.5	5.9	-1.9	2.1	2.1	2.4	-2.1
Pavlov. Cond. lever latency	4.0	5.6	7.6	-2.8	2.2	2.2	2.5	-2.1
Pavlov. Cond. magazine entry latency	0.4	0.6	0.8	-0.9	0.7	0.8	0.8	-0.4
Pavlov. Cond. change in total contacts	1.5	3.7	5.1	2.3	-1.8	-1.8	-1.9	1.8
Pavlov. Cond. index score	1.2	1.9	2.5	1.6	-1.3	-1.2	-1.4	1.3
Pavlov. Cond. latency score	0.7	1.1	1.7	1.3	-0.9	-0.8	-1.1	1.0
Pavlov. Cond. lever contacts	3.7	5.5	6.9	2.6	-2.3	-2.2	-2.4	2.2
Pavlov. Cond. magazine entry number	0.6	0.8	1.2	-0.8	0.9	0.8	0.9	-1.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.2	-0.1	-0.2	-0.1	-0.0
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.5	2.1	1.4	-1.1	-1.1	-1.3	1.2
Pavlov. Cond. response bias	3.6	5.0	5.7	2.4	-2.2	-2.1	-2.3	2.2
Time in closed arm before self-admin	2.5	4.3	5.3	-2.1	2.1	2.1	2.3	-1.7
Time in closed arm after self-admin	0.4	0.5	0.6	-0.7	0.6	0.6	0.7	-0.8
Time in open arm before self-admin	0.4	0.5	0.7	0.7	-0.7	-0.6	-0.8	0.7
Time in open arm after self-admin	0.1	0.1	0.2	0.4	0.1	0.1	-0.0	0.4
Bone: periosteal estimation	1.7	4.0	6.0	2.5	-1.8	-1.7	-2.2	1.7
Bone: periosteal perimeter	1.8	3.5	4.9	2.2	-1.8	-1.7	-1.8	1.8
Bone: post-yield work	1.4	2.5	3.5	1.9	-1.5	-1.4	-1.8	1.3
Progressive ratio test 1 active lever presses	1.3	2.3	3.9	2.0	-1.4	-1.4	-1.5	1.2
Progressive ratio test 1 breakpoint	1.1	2.0	3.5	1.9	-1.2	-1.2	-1.4	1.2
Progressive ratio test 1 inactive lever presses	0.4	1.2	2.2	1.5	-1.0	-1.0	-1.0	0.7
Progressive ratio test 2 active lever presses	0.1	0.2	0.4	-0.2	0.3	0.4	0.3	-0.6
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	-0.2	0.3	0.3	0.3	-0.6
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	-0.2	0.2	0.2	0.3	-0.4
Incentive Sensitization - Responses	1.2	3.2	4.0	-2.0	1.7	1.7	1.8	-1.8
Incentive Sensitization - Breakpoint	1.2	2.8	3.6	-1.9	1.5	1.6	1.6	-1.7
Sum of active levers in priming session hrs 5-6	0.8	0.8	1.0	0.9	-0.9	-1.0	-0.9	0.6
Progressive ratio	0.2	0.6	0.9	-0.9	0.8	0.8	0.5	-0.7
Food seeking constrained by brief footshock	0.2	0.2	0.3	-0.5	0.6	0.6	0.4	0.2
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.3	-0.1	-0.1	0.1	0.3
Retroperitoneal fat weight	0.4	1.8	2.7	0.7	-1.5	-1.6	-1.0	1.5
Reaction time number correct	0.2	0.8	1.1	0.9	-1.0	-1.0	-0.6	0.8
Reaction time mean minus median	1.8	11.8	13.3	-3.5	3.7	3.6	3.5	-2.9
Reaction time mean minus median AUC	1.6	10.5	11.8	-3.2	3.4	3.4	3.3	-2.8
Reaction time num false alarms	0.1	0.1	0.3	-0.3	0.5	0.5	0.3	0.0
Reaction time num false alarms AUC	0.1	0.2	0.4	-0.4	0.5	0.6	0.4	-0.1
Reaction time trials correct on left	0.2	0.8	1.1	0.9	-1.0	-1.0	-0.6	0.8
Reaction time trials on left	0.2	0.6	0.8	0.8	-0.8	-0.9	-0.5	0.7
Reaction time mean	3.5	7.7	9.3	-3.0	2.9	2.9	2.6	-2.4
Reaction time mean AUC	3.5	8.4	9.9	-3.1	3.0	3.1	2.7	-2.5
Median of all reaction times	2.7	4.2	5.4	-2.3	2.1	2.2	1.8	-1.7
Reaction time omissions	5.2	8.4	10.6	-2.7	3.2	3.3	2.5	-2.8
Reaction time false alarm rate	0.2	0.3	0.6	-0.5	0.7	0.8	0.4	-0.1
Reaction time premature initiation rate	2.0	3.1	4.4	2.1	-1.7	-1.8	-1.6	1.5
Reaction time premature initiations	1.4	4.3	5.8	2.4	-2.1	-2.2	-1.8	1.8
Std. dev. reaction times	3.3	11.0	12.3	-3.5	3.5	3.5	3.2	-2.9
Reaction time trials completed	0.2	0.6	0.8	0.8	-0.8	-0.9	-0.5	0.7
Reaction time trials AUC	0.2	0.8	1.1	0.8	-1.0	-1.0	-0.6	0.9
Run reversals in cocaine runway, females	1.7	1.9	2.5	-1.4	1.4	1.4	1.1	-1.6
Run reversals in cocaine runway, males	0.8	0.9	1.3	1.1	-0.9	-0.9	-0.9	1.0
Latency to leave start box in cocaine runway	1.6	2.2	3.3	-1.8	1.3	1.3	1.6	-1.3
Latency to leave start box in cocaine runway, F	1.2	1.5	2.5	-1.6	1.1	1.0	1.3	-0.9
Latency to leave start box in cocaine runway, M	0.8	0.8	1.1	-1.0	0.7	0.7	1.0	-0.8
Std. dev. time between licks in bursts	0.0	0.0	0.0	0.2	0.1	0.1	-0.2	-0.2
Total sessions with >9 infusions	1.4	1.8	1.9	1.4	-1.4	-1.3	-1.3	1.3
Short access day 1 total inactive lever presses	1.6	3.2	3.8	1.8	-2.0	-1.9	-1.9	1.2
Short access day 10 total inactive lever presses	0.0	0.1	0.4	-0.2	0.2	0.2	0.6	-0.4
Short access day 1 total infusions	2.8	5.6	5.9	2.4	-2.3	-2.2	-2.4	2.4
Short access day 10 total infusions	0.4	0.6	1.0	0.8	-0.7	-0.7	-0.6	1.0
Short access total infusions	2.0	2.8	3.3	1.8	-1.7	-1.6	-1.7	1.6
Short access day 1 locomotion	1.3	2.1	2.6	1.4	-1.6	-1.6	-1.2	1.4
Short access day 10 total locomotion	0.2	0.7	1.2	-0.8	0.8	0.8	1.1	-0.5
Short access total locomotion	0.2	0.3	0.5	0.4	-0.5	-0.6	-0.2	0.7
One hour access (0.3 mA shock)	1.1	1.3	1.6	1.0	-1.2	-1.1	-1.2	1.2
Compulsive drug intake	0.1	0.1	0.2	-0.0	0.3	0.3	-0.1	-0.5
One hour access (shock baseline)	0.1	0.4	0.9	0.3	-0.7	-0.5	-0.4	0.9
Social response proportion	0.6	0.7	1.2	0.9	-0.9	-0.9	-1.1	0.4
Social responses	0.5	0.7	1.1	1.1	-0.7	-0.7	-1.0	0.4
Social time	2.0	3.2	4.9	1.8	-1.7	-1.6	-2.2	1.4
Soleus weight	1.7	5.0	8.0	2.8	-2.0	-2.0	-2.5	1.7
Bone: stiffness	0.5	0.8	1.2	1.1	-0.8	-0.8	-1.0	0.8
Tibialis anterior weight	8.6	29.7	31.7	5.6	-5.5	-5.5	-5.4	5.2
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.4	-0.1	0.5	0.5	0.3	-0.6
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.4	0.6	-0.0	-0.1	-0.2	0.0
Time to tail flick, test, before self-admin	1.2	1.4	2.0	-1.4	1.2	1.2	1.3	-0.6
Time to tail flick, test, after self-admin	2.2	2.3	3.1	1.7	-1.3	-1.2	-1.8	1.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.5	0.7	-0.5	-0.5	-0.6	0.4
Delta time to tail flick, test, before/after SA	0.8	1.0	1.6	1.3	-0.8	-0.8	-1.2	0.6
Tibia length	0.7	2.0	3.2	1.8	-1.3	-1.3	-1.4	1.2
Ambulatory time before self-admin	0.0	0.0	0.2	0.4	0.1	0.1	-0.1	0.2
Ambulatory time after self-admin	0.0	0.0	0.1	-0.2	0.2	0.1	0.3	0.2
Bone: tissue strength	0.4	0.4	0.6	0.7	-0.6	-0.6	-0.8	0.5
Total heroin consumption	1.8	2.2	2.6	1.6	-1.5	-1.5	-1.5	1.2
Bone: trabecular number	7.0	13.2	16.5	3.2	-3.9	-3.9	-3.1	4.1
Bone: trabecular spacing	8.9	13.1	14.1	-3.8	3.6	3.6	3.4	-3.7
Bone: trabecular thickness	4.7	6.5	6.9	2.5	-2.6	-2.6	-2.4	2.6
Bone: trabecular tissue density	1.2	2.1	3.3	-1.0	1.6	1.6	1.0	-1.8
Water consumed over 24 hours	0.2	0.4	0.6	0.3	-0.7	-0.7	-0.4	0.7
Number of responses in last shaping day	0.4	0.5	1.0	1.0	-0.7	-0.8	-0.5	0.5