Hub : Genes

LOC120103488

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye isoform ratio XR_005505731.2 0.46 0.21 6.2e-04 0.11 0.06 0.03 0.07 1.0e-02 4.4e-02 1.3e-01 3.7e-02
2 Liver gene expression LOC120103488 0.03 0.03 4.0e-03 0.01 0 0 0 6.3e-02 1.4e-01 3.0e-01 1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density3.15.77.62.0-2.8
Area under the delay curve0.10.10.2-0.1-0.4
BMI with tail0.72.53.8-2.01.0
BMI without tail0.63.34.5-2.11.4
Body weight2.711.613.5-3.73.1
Weight adjusted by age0.10.40.50.7-0.5
Bone surface1.42.74.70.9-2.2
Bone volume1.32.74.50.9-2.1
Breakpoint value in progressive ratio session0.50.81.30.6-1.2
Number of licking bursts0.10.40.9-0.9-0.1
Context. condit. distance diff. score0.10.10.20.5-0.0
Locomotion velocity, session 10.30.40.7-0.80.3
Locomotion distance, session 10.81.01.80.5-1.3
Locomotion velocity, session 20.30.30.4-0.50.6
Locomotion distance, session 20.10.10.2-0.40.0
Locomotion velocity, session 31.11.31.61.3-1.0
Locomotion distance, session 30.40.50.80.5-0.9
Stereotopy head waving bouts, day 32.32.73.01.7-1.5
Stereotopy head waving duration, day 30.30.30.50.7-0.4
Locomotion velocity, session 70.70.81.50.2-1.2
Locomotion distance, session 70.40.50.9-0.9-0.4
Stereotopy head waving bouts, day 70.10.10.20.50.1
Stereotopy head waving duration, day 70.91.11.91.4-0.5
Locomotion velocity, session 80.40.50.70.8-0.7
Locomotion distance, session 80.20.30.40.5-0.6
Degree of sensitization distance1.31.42.1-1.40.8
Degree of sensitization stereotypy0.20.20.50.00.7
Conditioned locomotion3.84.45.22.3-1.9
Cocaine response after cond. corrected0.20.40.70.1-0.9
Cocaine response after cond. not corrected0.71.01.50.8-1.2
Cocaine response before conditioning2.32.74.22.0-1.1
Saline control response1.11.52.11.5-0.9
Bone: connectivity density3.04.86.51.7-2.5
Bone: cortical apparent density0.20.30.50.3-0.7
Bone: cortical area0.30.40.9-0.1-0.9
Bone: cortical porosity2.02.23.41.8-1.0
Bone: cortical porosity1.61.82.31.5-1.1
Bone: cortical thickness0.10.10.3-0.50.2
Bone: cortical thickness0.91.11.80.6-1.4
Bone: cortical tissue density0.10.20.30.1-0.6
Condit. Reinf. active minus inactive responses1.11.21.8-1.30.8
Condit. Reinf. active-inactive response ratio1.21.31.9-1.40.8
Condit. Reinf. active responses0.00.00.0-0.2-0.2
Condit. Reinf. inactive responses0.91.21.31.1-1.1
Incentive salience index mean0.20.20.4-0.6-0.1
Condit. Reinf. lever presses0.30.50.80.4-0.9
Condit. Reinf. active minus inactive responses4.16.38.42.9-2.1
Condit. Reinf. active-inactive response ratio1.72.74.72.2-0.8
Condit. Reinf. active responses3.34.85.32.3-2.1
Condit. Reinf. inactive responses0.91.32.50.5-1.6
Condit. Reinf. lever presses2.43.54.02.0-1.8
Condit. Reinf. lever reinforcers received3.44.85.62.4-2.0
Conditioned reinforcement - actives1.24.76.12.5-1.8
Conditioned reinforcement - inactives1.33.53.91.8-2.0
Conditioned locomotion1.01.52.21.5-0.9
Patch foraging indifference point 0 sec0.30.80.8-0.90.9
Patch foraging indifference point AUC0.30.71.50.2-1.2
Delay disc. indifference point, 0s delay3.33.84.5-2.11.8
Delay disc. indifference point, 16s delay0.00.00.10.3-0.1
Delay disc. indifference point, 2s delay0.20.20.3-0.50.3
Delay disc. indifference point, 24s delay0.71.11.11.0-1.0
Delay disc. indifference point, 4s delay0.10.10.2-0.5-0.2
Delay disc. indifference point, 8s delay0.00.10.10.1-0.4
Indifference point function ln k0.20.50.90.9-0.2
Indifference point function log k0.20.50.90.9-0.2
Patch foraging total patch changes 0 sec0.30.80.9-0.90.8
Patch foraging total patch changes 12 sec1.52.12.5-1.61.3
Patch foraging total patch changes 18 sec0.20.40.8-0.90.3
Patch foraging total patch changes 24 sec0.41.31.3-1.11.1
Patch foraging total patch changes 6 sec0.40.71.1-1.00.6
Patch foraging time to switch 0 sec0.00.00.1-0.20.2
Patch foraging water rate 0 sec0.10.40.70.8-0.2
Patch foraging water rate 12 sec0.31.11.9-0.51.4
Patch foraging water rate 18 sec0.30.61.00.51.0
Patch foraging water rate 24 sec1.11.52.4-0.81.5
Patch foraging water rate 6 sec0.71.01.9-0.41.4
Seeking ratio, delayed vs. immediate footshock0.00.00.00.00.2
Distance traveled before self-admin0.00.00.00.20.1
Distance traveled after self-admin1.62.82.9-1.71.7
Extensor digitorum longus weight4.317.218.04.0-4.2
Bone: elastic displacement0.70.91.00.9-1.0
Bone: elastic work0.71.01.50.7-1.2
Bone: endosteal estimation0.41.02.00.0-1.4
Bone: endosteal perimeter0.20.40.9-0.2-0.9
Epididymis fat weight10.854.557.8-7.67.2
Delta time in closed arm before/after self-admin0.10.10.1-0.3-0.2
Delta time in open arm before/after self-admin0.10.10.10.2-0.3
Diff in mean of infusions in LGA sessions0.00.00.0-0.2-0.2
Delay discount exponential model param0.20.30.5-0.30.7
Extinction: sum of active levers before priming0.10.20.30.1-0.6
Active lever presses in extinction session 61.01.01.01.0-1.0
Bone: final force0.10.20.3-0.3-0.5
Bone: final moment0.10.20.3-0.4-0.6
Food consumed during 24 hour testing period0.00.10.10.2-0.3
Glucose0.30.40.6-0.80.5
Heart weight3.55.65.9-2.32.4
Delay discount hyperbolic model param0.10.10.3-0.00.5
Intermittent access intake day 1-15 change0.10.40.60.8-0.4
Intermittent access intake escalation0.00.10.20.4-0.0
Intermittent access intake escalation 20.00.00.00.20.2
Intermitt. access day 1 inactive lever presses0.11.92.21.5-1.3
Intermitt. access day 15 inactive lever presses0.95.16.32.0-2.5
Intermitt. access escalation Index0.51.72.8-1.70.8
Intermittent access day 1 total infusions1.95.66.12.5-2.3
Intermittent access day 15 total infusions1.12.83.41.8-1.5
Intermittent access terminal intake (last 3 days)2.23.94.92.2-1.7
Intermittent access total infusions3.74.45.42.3-1.8
Intermittent access day 1 locomotion1.42.62.71.7-1.6
Intermittent access day 15 total locomotion0.10.60.60.7-0.8
Intermittent access total locomotion0.81.01.01.0-0.9
Intermittent access standard deviation0.31.81.91.4-1.3
Left kidney weight0.00.00.0-0.10.1
Right kidney weight0.32.32.5-1.51.6
Cocaine induced anxiety0.00.10.20.1-0.5
Post-drug Anxiety1.71.92.4-1.61.2
Baseline Anxiety2.23.73.8-2.01.9
Tail length0.21.31.6-1.01.2
Length with tail1.46.27.4-2.22.7
Length without tail0.31.71.7-1.31.3
Times rat made contact with spout1.71.92.31.2-1.5
Lifetime Intake3.74.65.32.3-2.0
Liver weight, left3.96.76.7-2.62.6
Liver weight, right9.516.718.5-3.84.3
Locomotor activity0.61.01.6-1.30.6
Locomotor testing distance0.10.10.2-0.3-0.4
Locomotor testing rearing0.41.41.91.0-1.4
Locomotion in novel chamber0.00.00.00.00.2
Locomotion in novel chamber post-restriction1.54.44.8-2.02.2
Fecal boli incidents, locomotor time 10.20.50.91.0-0.3
Change in fecal boli incidents, locomotor task4.24.55.4-2.31.9
Time >=10cm from walls, locomotor time 10.00.00.0-0.00.0
Bouts of movement, locomotor time 11.41.92.11.3-1.5
Total resting periods, locomotor time 11.82.02.31.3-1.5
Rest time, locomotor task time 10.00.00.0-0.10.1
Distance moved, locomotor task time 10.51.51.6-1.21.2
Vertical activity count, locomotor time 10.10.70.8-0.90.8
Time >=10cm from walls, locomotor time 20.20.70.90.7-0.9
Bouts of movement, locomotor time 20.00.00.0-0.1-0.1
Total resting periods, locomotor time 20.00.10.20.2-0.4
Rest time, locomotor task time 20.71.21.61.0-1.3
Distance moved, locomotor task time 20.91.21.2-1.11.1
Vertical activity count, locomotor time 20.10.30.4-0.60.5
Light reinforcement 11.14.96.41.9-2.5
Light reinforcement 21.53.43.81.7-2.0
Bone: marrow area0.41.02.00.0-1.4
Bone: maximum diameter0.61.22.40.1-1.5
Bone: maximum force0.10.20.4-0.0-0.6
Bone: maximum moment0.10.20.4-0.0-0.7
Mean time between licks in bursts0.74.24.5-2.02.1
Mean num. licks in bursts0.30.91.51.2-0.5
Cd content in liver0.00.00.0-0.2-0.1
Co content in liver5.26.27.12.3-2.7
Cu content in liver0.10.10.10.3-0.2
Fe content in liver0.80.91.00.9-1.0
K content in liver0.40.40.4-0.6-0.6
Mg content in liver0.40.40.5-0.7-0.6
Mn content in liver0.20.30.4-0.6-0.4
Na content in liver0.50.50.60.8-0.7
Rb content in liver0.20.20.4-0.6-0.0
Se content in liver0.10.10.2-0.40.2
Sr content in liver0.10.10.2-0.10.4
Zn content in liver1.31.52.2-1.50.9
Bone: minimum diameter0.40.71.4-1.20.1
Time in familiar zone, hab. session 11.11.21.8-1.30.8
Time in novel zone, hab. session 10.20.20.40.20.6
Total zone transitions, hab. session 10.10.20.20.5-0.3
Total locomotion distance, hab. session 10.10.10.20.2-0.4
Locomotion velocity, hab. session 10.60.81.10.8-1.0
Time in familiar zone, hab. session 20.00.00.0-0.0-0.2
Time in novel zone, hab. session 20.50.50.6-0.70.8
Total zone transitions, hab. session 20.00.00.0-0.2-0.2
Total locomotion distance, hab. session 20.00.00.10.0-0.3
Locomotion velocity, hab. session 20.10.10.20.2-0.5
Novel to familiar place preference ratio0.71.01.1-0.91.0
Novelty place preference1.11.51.7-1.11.3
Time in novel zone, NPP test1.31.62.0-1.11.4
Total zone transitions, NPP test1.01.51.51.2-1.2
Total locomotion distance, NPP test1.72.32.51.6-1.5
Locomotion velocity, NPP test2.63.73.91.8-2.0
Intraocular pressure5.59.09.5-3.12.9
Delta distance traveled before/after self-admin2.12.42.6-1.61.5
Delta ambulatory time before/after self-admin0.40.71.0-1.00.6
Parametrial fat weight13.431.533.2-5.85.5
Pavlov. Cond. lever latency1.01.32.0-0.81.4
Pavlov. Cond. magazine entry latency0.00.00.00.0-0.2
Pavlov. Cond. change in total contacts0.00.00.0-0.1-0.1
Pavlov. Cond. index score0.30.40.70.2-0.8
Pavlov. Cond. latency score0.30.40.80.2-0.9
Pavlov. Cond. lever contacts0.60.71.20.5-1.1
Pavlov. Cond. magazine entry number0.20.20.4-0.30.6
Pavlov. Cond. intertrial magazine entries1.01.21.31.2-1.0
Pavlov. Cond. lever-magazine prob. diff.0.70.91.40.6-1.2
Pavlov. Cond. response bias0.81.01.30.8-1.1
Pavlov. Cond. lever latency1.72.42.6-1.51.6
Pavlov. Cond. magazine entry latency0.30.40.60.4-0.8
Pavlov. Cond. change in total contacts0.61.51.71.2-1.3
Pavlov. Cond. index score1.32.02.31.3-1.5
Pavlov. Cond. latency score1.32.12.51.3-1.6
Pavlov. Cond. lever contacts1.21.71.81.3-1.4
Pavlov. Cond. magazine entry number0.20.30.5-0.20.7
Pavlov. Cond. intertrial magazine entries2.34.95.7-2.02.4
Pavlov. Cond. lever-magazine prob. diff.0.81.31.71.0-1.3
Pavlov. Cond. response bias1.82.52.71.5-1.6
Time in closed arm before self-admin0.40.70.7-0.80.8
Time in closed arm after self-admin0.80.90.9-0.90.9
Time in open arm before self-admin0.00.00.00.1-0.1
Time in open arm after self-admin0.80.91.10.8-1.1
Bone: periosteal estimation0.51.22.40.1-1.6
Bone: periosteal perimeter0.20.40.9-0.0-0.9
Bone: post-yield work1.01.82.01.4-1.3
Progressive ratio test 1 active lever presses1.42.42.91.7-1.4
Progressive ratio test 1 breakpoint1.42.52.91.7-1.4
Progressive ratio test 1 inactive lever presses1.95.05.52.4-2.1
Progressive ratio test 2 active lever presses0.81.11.71.3-0.7
Progressive ratio test 2 breakpoint0.70.91.41.2-0.6
Progressive ratio test 2 inactive lever presses0.92.93.31.8-1.6
Incentive Sensitization - Responses0.10.30.50.7-0.4
Incentive Sensitization - Breakpoint0.10.20.30.5-0.2
Sum of active levers in priming session hrs 5-60.20.20.2-0.5-0.3
Progressive ratio0.00.00.1-0.20.0
Food seeking constrained by brief footshock4.86.07.72.8-2.1
Seeking ratio, punishment vs. effort0.30.71.01.0-0.5
Retroperitoneal fat weight23.0103.0114.4-10.79.6
Reaction time number correct0.20.80.90.9-0.9
Reaction time mean minus median0.00.10.20.4-0.0
Reaction time mean minus median AUC0.00.00.1-0.10.2
Reaction time num false alarms0.30.40.9-0.90.1
Reaction time num false alarms AUC0.20.51.0-1.00.1
Reaction time trials correct on left0.20.80.90.9-0.9
Reaction time trials on left0.20.80.90.9-0.9
Reaction time mean0.71.61.9-1.11.4
Reaction time mean AUC0.61.31.7-1.01.3
Median of all reaction times1.32.02.2-1.31.5
Reaction time omissions0.00.10.1-0.2-0.3
Reaction time false alarm rate0.81.11.9-1.40.5
Reaction time premature initiation rate0.10.10.2-0.10.4
Reaction time premature initiations0.00.10.10.4-0.1
Std. dev. reaction times0.10.30.5-0.40.7
Reaction time trials completed0.20.80.90.9-0.9
Reaction time trials AUC0.31.11.21.1-1.0
Run reversals in cocaine runway, females0.10.10.20.30.4
Run reversals in cocaine runway, males0.30.30.60.8-0.1
Latency to leave start box in cocaine runway0.50.70.80.8-0.9
Latency to leave start box in cocaine runway, F0.10.20.30.2-0.5
Latency to leave start box in cocaine runway, M0.50.50.80.9-0.4
Std. dev. time between licks in bursts0.40.81.4-1.20.4
Total sessions with >9 infusions1.72.12.51.6-1.3
Short access day 1 total inactive lever presses3.87.69.02.5-3.0
Short access day 10 total inactive lever presses0.53.43.51.8-1.9
Short access day 1 total infusions3.26.36.62.5-2.6
Short access day 10 total infusions2.03.23.71.9-1.7
Short access total infusions1.62.32.51.6-1.5
Short access day 1 locomotion3.45.66.52.5-2.2
Short access day 10 total locomotion0.72.83.71.9-1.4
Short access total locomotion0.50.71.01.0-0.6
One hour access (0.3 mA shock)1.92.33.11.8-1.2
Compulsive drug intake1.62.43.0-1.71.3
One hour access (shock baseline)1.74.45.92.4-1.7
Social response proportion0.10.20.2-0.40.4
Social responses0.10.10.2-0.40.3
Social time0.10.10.2-0.30.5
Soleus weight4.112.113.33.3-3.6
Bone: stiffness0.00.00.10.2-0.1
Tibialis anterior weight3.311.313.33.1-3.6
Time to tail flick, vehicle, before self-admin0.40.50.8-0.30.9
Time to tail flick, vehicle, after self-admin1.63.23.3-1.81.8
Time to tail flick, test, before self-admin0.10.10.10.3-0.3
Time to tail flick, test, after self-admin0.40.40.70.8-0.3
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.60.1
Delta time to tail flick, test, before/after SA1.21.51.81.3-1.2
Tibia length2.77.67.8-2.82.7
Ambulatory time before self-admin0.00.00.10.30.0
Ambulatory time after self-admin1.21.92.0-1.31.4
Bone: tissue strength0.80.81.2-0.71.1
Total heroin consumption2.42.93.31.6-1.8
Bone: trabecular number1.93.75.21.4-2.3
Bone: trabecular spacing2.13.14.6-1.32.2
Bone: trabecular thickness0.40.61.1-0.0-1.1
Bone: trabecular tissue density0.30.50.70.8-0.5
Water consumed over 24 hours0.10.30.50.0-0.7
Number of responses in last shaping day0.40.50.60.6-0.8