Hub : Genes

LOC120103488

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye isoform ratio XR_005505731.2 0.46 0.21 6.2e-04 0.11 0.06 0.03 0.07 1.0e-02 4.4e-02 1.3e-01 3.5e-02
2 Liver gene expression LOC120103488 0.03 0.03 4.0e-03 0.01 0 0 0 6.3e-02 1.4e-01 3.0e-01 1.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density3.35.77.6-2.02.8
Area under the delay curve0.10.10.20.10.4
BMI with tail0.72.53.82.0-1.0
BMI without tail1.13.34.52.1-1.4
Body weight2.711.613.53.7-3.1
Weight adjusted by age0.20.40.5-0.70.5
Bone surface1.52.74.7-0.92.2
Bone volume1.52.74.5-0.92.1
Breakpoint value in progressive ratio session0.70.81.3-0.61.2
Number of licking bursts0.30.40.90.90.1
Context. condit. distance diff. score0.10.10.2-0.50.0
Locomotion velocity, session 10.40.40.70.8-0.3
Locomotion distance, session 10.81.01.8-0.51.3
Locomotion velocity, session 20.30.30.40.5-0.6
Locomotion distance, session 20.10.10.20.4-0.0
Locomotion velocity, session 31.11.31.6-1.31.0
Locomotion distance, session 30.50.50.8-0.50.9
Stereotopy head waving bouts, day 32.32.73.0-1.71.5
Stereotopy head waving duration, day 30.30.30.5-0.70.4
Locomotion velocity, session 70.70.81.5-0.21.2
Locomotion distance, session 70.40.50.90.90.4
Stereotopy head waving bouts, day 70.10.10.2-0.5-0.1
Stereotopy head waving duration, day 70.91.11.9-1.40.5
Locomotion velocity, session 80.50.50.7-0.80.7
Locomotion distance, session 80.20.30.4-0.50.6
Degree of sensitization distance1.41.42.11.4-0.8
Degree of sensitization stereotypy0.20.20.5-0.0-0.7
Conditioned locomotion3.94.45.2-2.31.9
Cocaine response after cond. corrected0.30.40.7-0.10.9
Cocaine response after cond. not corrected0.91.01.5-0.81.2
Cocaine response before conditioning2.32.74.2-2.01.1
Saline control response1.11.52.1-1.50.9
Bone: connectivity density3.04.86.5-1.72.5
Bone: cortical apparent density0.20.30.5-0.30.7
Bone: cortical area0.30.40.90.10.9
Bone: cortical porosity2.02.23.4-1.81.0
Bone: cortical porosity1.61.82.3-1.51.1
Bone: cortical thickness0.10.10.30.5-0.2
Bone: cortical thickness0.91.11.8-0.61.4
Bone: cortical tissue density0.10.20.3-0.10.6
Condit. Reinf. active minus inactive responses1.11.21.81.3-0.8
Condit. Reinf. active-inactive response ratio1.21.31.91.4-0.8
Condit. Reinf. active responses0.00.00.00.20.2
Condit. Reinf. inactive responses1.01.21.3-1.11.1
Incentive salience index mean0.20.20.40.60.1
Condit. Reinf. lever presses0.30.50.8-0.40.9
Condit. Reinf. active minus inactive responses4.96.38.4-2.92.1
Condit. Reinf. active-inactive response ratio2.32.74.7-2.20.8
Condit. Reinf. active responses3.44.85.3-2.32.1
Condit. Reinf. inactive responses1.01.32.5-0.51.6
Condit. Reinf. lever presses2.63.54.0-2.01.8
Condit. Reinf. lever reinforcers received3.44.85.6-2.42.0
Conditioned reinforcement - actives2.74.76.1-2.51.8
Conditioned reinforcement - inactives2.43.53.9-1.82.0
Conditioned locomotion1.21.52.2-1.50.9
Patch foraging indifference point 0 sec0.40.80.80.9-0.9
Patch foraging indifference point AUC0.50.71.5-0.21.2
Delay disc. indifference point, 0s delay3.43.84.52.1-1.8
Delay disc. indifference point, 16s delay0.00.00.1-0.30.1
Delay disc. indifference point, 2s delay0.20.20.30.5-0.3
Delay disc. indifference point, 24s delay1.01.11.1-1.01.0
Delay disc. indifference point, 4s delay0.10.10.20.50.2
Delay disc. indifference point, 8s delay0.10.10.1-0.10.4
Indifference point function ln k0.30.50.9-0.90.2
Indifference point function log k0.30.50.9-0.90.2
Patch foraging total patch changes 0 sec0.40.80.90.9-0.8
Patch foraging total patch changes 12 sec1.62.12.51.6-1.3
Patch foraging total patch changes 18 sec0.30.40.80.9-0.3
Patch foraging total patch changes 24 sec0.71.31.31.1-1.1
Patch foraging total patch changes 6 sec0.50.71.11.0-0.6
Patch foraging time to switch 0 sec0.00.00.10.2-0.2
Patch foraging water rate 0 sec0.20.40.7-0.80.2
Patch foraging water rate 12 sec0.51.11.90.5-1.4
Patch foraging water rate 18 sec0.40.61.0-0.5-1.0
Patch foraging water rate 24 sec1.11.52.40.8-1.5
Patch foraging water rate 6 sec0.71.01.90.4-1.4
Seeking ratio, delayed vs. immediate footshock0.00.00.0-0.0-0.2
Distance traveled before self-admin0.00.00.0-0.2-0.1
Distance traveled after self-admin2.32.82.91.7-1.7
Extensor digitorum longus weight4.417.218.0-4.04.2
Bone: elastic displacement0.80.91.0-0.91.0
Bone: elastic work0.71.01.5-0.71.2
Bone: endosteal estimation0.51.02.0-0.01.4
Bone: endosteal perimeter0.20.40.90.20.9
Epididymis fat weight15.954.557.87.6-7.2
Delta time in closed arm before/after self-admin0.10.10.10.30.2
Delta time in open arm before/after self-admin0.10.10.1-0.20.3
Diff in mean of infusions in LGA sessions0.00.00.00.20.2
Delay discount exponential model param0.20.30.50.3-0.7
Extinction: sum of active levers before priming0.20.20.3-0.10.6
Active lever presses in extinction session 61.01.01.0-1.01.0
Bone: final force0.10.20.30.30.5
Bone: final moment0.10.20.30.40.6
Food consumed during 24 hour testing period0.00.10.1-0.20.3
Glucose0.30.40.60.8-0.5
Heart weight3.65.65.92.3-2.4
Delay discount hyperbolic model param0.10.10.30.0-0.5
Intermittent access intake day 1-15 change0.20.40.6-0.80.4
Intermittent access intake escalation0.00.10.2-0.40.0
Intermittent access intake escalation 20.00.00.0-0.2-0.2
Intermitt. access day 1 inactive lever presses0.51.92.2-1.51.3
Intermitt. access day 15 inactive lever presses2.55.16.3-2.02.5
Intermitt. access escalation Index1.21.72.81.7-0.8
Intermittent access day 1 total infusions3.55.66.1-2.52.3
Intermittent access day 15 total infusions1.92.83.4-1.81.5
Intermittent access terminal intake (last 3 days)3.03.94.9-2.21.7
Intermittent access total infusions3.74.45.4-2.31.8
Intermittent access day 1 locomotion2.12.62.7-1.71.6
Intermittent access day 15 total locomotion0.30.60.6-0.70.8
Intermittent access total locomotion0.81.01.0-1.00.9
Intermittent access standard deviation0.91.81.9-1.41.3
Left kidney weight0.00.00.00.1-0.1
Right kidney weight0.52.32.51.5-1.6
Cocaine induced anxiety0.10.10.2-0.10.5
Post-drug Anxiety1.81.92.41.6-1.2
Baseline Anxiety3.23.73.82.0-1.9
Tail length0.31.31.61.0-1.2
Length with tail1.46.27.42.2-2.7
Length without tail0.51.71.71.3-1.3
Times rat made contact with spout1.71.92.3-1.21.5
Lifetime Intake3.84.65.3-2.32.0
Liver weight, left4.06.76.72.6-2.6
Liver weight, right9.516.718.53.8-4.3
Locomotor activity0.61.01.61.3-0.6
Locomotor testing distance0.10.10.20.30.4
Locomotor testing rearing0.71.41.9-1.01.4
Locomotion in novel chamber0.00.00.0-0.0-0.2
Locomotion in novel chamber post-restriction2.74.44.82.0-2.2
Fecal boli incidents, locomotor time 10.30.50.9-1.00.3
Change in fecal boli incidents, locomotor task4.64.55.42.3-1.9
Time >=10cm from walls, locomotor time 10.00.00.00.0-0.0
Bouts of movement, locomotor time 11.61.92.1-1.31.5
Total resting periods, locomotor time 11.82.02.3-1.31.5
Rest time, locomotor task time 10.00.00.00.1-0.1
Distance moved, locomotor task time 11.01.51.61.2-1.2
Vertical activity count, locomotor time 10.30.70.80.9-0.8
Time >=10cm from walls, locomotor time 20.50.70.9-0.70.9
Bouts of movement, locomotor time 20.00.00.00.10.1
Total resting periods, locomotor time 20.10.10.2-0.20.4
Rest time, locomotor task time 21.01.21.6-1.01.3
Distance moved, locomotor task time 21.01.21.21.1-1.1
Vertical activity count, locomotor time 20.20.30.40.6-0.5
Light reinforcement 12.04.96.4-1.92.5
Light reinforcement 22.23.43.8-1.72.0
Bone: marrow area0.51.02.0-0.01.4
Bone: maximum diameter0.61.22.4-0.11.5
Bone: maximum force0.10.20.40.00.6
Bone: maximum moment0.10.20.40.00.7
Mean time between licks in bursts1.74.24.52.0-2.1
Mean num. licks in bursts0.60.91.5-1.20.5
Cd content in liver0.00.00.00.20.1
Co content in liver5.36.27.1-2.32.7
Cu content in liver0.10.10.1-0.30.2
Fe content in liver0.80.91.0-0.91.0
K content in liver0.40.40.40.60.6
Mg content in liver0.40.40.50.70.6
Mn content in liver0.20.30.40.60.4
Na content in liver0.50.50.6-0.80.7
Rb content in liver0.20.20.40.60.0
Se content in liver0.10.10.20.4-0.2
Sr content in liver0.10.10.20.1-0.4
Zn content in liver1.41.52.21.5-0.9
Bone: minimum diameter0.40.71.41.2-0.1
Time in familiar zone, hab. session 11.21.21.81.3-0.8
Time in novel zone, hab. session 10.20.20.4-0.2-0.6
Total zone transitions, hab. session 10.10.20.2-0.50.3
Total locomotion distance, hab. session 10.10.10.2-0.20.4
Locomotion velocity, hab. session 10.60.81.1-0.81.0
Time in familiar zone, hab. session 20.00.00.00.00.2
Time in novel zone, hab. session 20.50.50.60.7-0.8
Total zone transitions, hab. session 20.00.00.00.20.2
Total locomotion distance, hab. session 20.00.00.1-0.00.3
Locomotion velocity, hab. session 20.10.10.2-0.20.5
Novel to familiar place preference ratio0.91.01.10.9-1.0
Novelty place preference1.41.51.71.1-1.3
Time in novel zone, NPP test1.51.62.01.1-1.4
Total zone transitions, NPP test1.01.51.5-1.21.2
Total locomotion distance, NPP test1.72.32.5-1.61.5
Locomotion velocity, NPP test2.63.73.9-1.82.0
Intraocular pressure6.39.09.53.1-2.9
Delta distance traveled before/after self-admin2.22.42.61.6-1.5
Delta ambulatory time before/after self-admin0.50.71.01.0-0.6
Parametrial fat weight13.431.533.25.8-5.5
Pavlov. Cond. lever latency1.01.32.00.8-1.4
Pavlov. Cond. magazine entry latency0.00.00.0-0.00.2
Pavlov. Cond. change in total contacts0.00.00.00.10.1
Pavlov. Cond. index score0.30.40.7-0.20.8
Pavlov. Cond. latency score0.30.40.8-0.20.9
Pavlov. Cond. lever contacts0.60.71.2-0.51.1
Pavlov. Cond. magazine entry number0.20.20.40.3-0.6
Pavlov. Cond. intertrial magazine entries1.01.21.3-1.21.0
Pavlov. Cond. lever-magazine prob. diff.0.70.91.4-0.61.2
Pavlov. Cond. response bias0.81.01.3-0.81.1
Pavlov. Cond. lever latency1.82.42.61.5-1.6
Pavlov. Cond. magazine entry latency0.30.40.6-0.40.8
Pavlov. Cond. change in total contacts0.91.51.7-1.21.3
Pavlov. Cond. index score1.52.02.3-1.31.5
Pavlov. Cond. latency score1.62.12.5-1.31.6
Pavlov. Cond. lever contacts1.21.71.8-1.31.4
Pavlov. Cond. magazine entry number0.20.30.50.2-0.7
Pavlov. Cond. intertrial magazine entries3.34.95.72.0-2.4
Pavlov. Cond. lever-magazine prob. diff.1.01.31.7-1.01.3
Pavlov. Cond. response bias1.92.52.7-1.51.6
Time in closed arm before self-admin0.50.70.70.8-0.8
Time in closed arm after self-admin0.80.90.90.9-0.9
Time in open arm before self-admin0.00.00.0-0.10.1
Time in open arm after self-admin0.80.91.1-0.81.1
Bone: periosteal estimation0.61.22.4-0.11.6
Bone: periosteal perimeter0.30.40.90.00.9
Bone: post-yield work1.21.82.0-1.41.3
Progressive ratio test 1 active lever presses2.02.42.9-1.71.4
Progressive ratio test 1 breakpoint2.02.52.9-1.71.4
Progressive ratio test 1 inactive lever presses3.55.05.5-2.42.1
Progressive ratio test 2 active lever presses1.01.11.7-1.30.7
Progressive ratio test 2 breakpoint0.80.91.4-1.20.6
Progressive ratio test 2 inactive lever presses1.82.93.3-1.81.6
Incentive Sensitization - Responses0.20.30.5-0.70.4
Incentive Sensitization - Breakpoint0.10.20.3-0.50.2
Sum of active levers in priming session hrs 5-60.20.20.20.50.3
Progressive ratio0.00.00.10.2-0.0
Food seeking constrained by brief footshock4.96.07.7-2.82.1
Seeking ratio, punishment vs. effort0.50.71.0-1.00.5
Retroperitoneal fat weight24.2103.0114.410.7-9.6
Reaction time number correct0.40.80.9-0.90.9
Reaction time mean minus median0.00.10.2-0.40.0
Reaction time mean minus median AUC0.00.00.10.1-0.2
Reaction time num false alarms0.30.40.90.9-0.1
Reaction time num false alarms AUC0.30.51.01.0-0.1
Reaction time trials correct on left0.40.80.9-0.90.9
Reaction time trials on left0.50.80.9-0.90.9
Reaction time mean1.01.61.91.1-1.4
Reaction time mean AUC0.81.31.71.0-1.3
Median of all reaction times1.42.02.21.3-1.5
Reaction time omissions0.00.10.10.20.3
Reaction time false alarm rate0.81.11.91.4-0.5
Reaction time premature initiation rate0.10.10.20.1-0.4
Reaction time premature initiations0.00.10.1-0.40.1
Std. dev. reaction times0.20.30.50.4-0.7
Reaction time trials completed0.50.80.9-0.90.9
Reaction time trials AUC0.61.11.2-1.11.0
Run reversals in cocaine runway, females0.10.10.2-0.3-0.4
Run reversals in cocaine runway, males0.30.30.6-0.80.1
Latency to leave start box in cocaine runway0.60.70.8-0.80.9
Latency to leave start box in cocaine runway, F0.10.20.3-0.20.5
Latency to leave start box in cocaine runway, M0.50.50.8-0.90.4
Std. dev. time between licks in bursts0.60.81.41.2-0.4
Total sessions with >9 infusions1.72.12.5-1.61.3
Short access day 1 total inactive lever presses5.87.69.0-2.53.0
Short access day 10 total inactive lever presses1.43.43.5-1.81.9
Short access day 1 total infusions4.86.36.6-2.52.6
Short access day 10 total infusions2.53.23.7-1.91.7
Short access total infusions1.82.32.5-1.61.5
Short access day 1 locomotion4.55.66.5-2.52.2
Short access day 10 total locomotion1.52.83.7-1.91.4
Short access total locomotion0.60.71.0-1.00.6
One hour access (0.3 mA shock)2.02.33.1-1.81.2
Compulsive drug intake2.02.43.01.7-1.3
One hour access (shock baseline)2.94.45.9-2.41.7
Social response proportion0.10.20.20.4-0.4
Social responses0.10.10.20.4-0.3
Social time0.10.10.20.3-0.5
Soleus weight4.112.113.3-3.33.6
Bone: stiffness0.00.00.1-0.20.1
Tibialis anterior weight3.311.313.3-3.13.6
Time to tail flick, vehicle, before self-admin0.40.50.80.3-0.9
Time to tail flick, vehicle, after self-admin2.43.23.31.8-1.8
Time to tail flick, test, before self-admin0.10.10.1-0.30.3
Time to tail flick, test, after self-admin0.40.40.7-0.80.3
Delta time to tail flick, vehicle, before/after SA0.20.20.40.6-0.1
Delta time to tail flick, test, before/after SA1.51.51.8-1.31.2
Tibia length2.87.67.82.8-2.7
Ambulatory time before self-admin0.00.00.1-0.3-0.0
Ambulatory time after self-admin1.61.92.01.3-1.4
Bone: tissue strength0.80.81.20.7-1.1
Total heroin consumption2.42.93.3-1.61.8
Bone: trabecular number2.23.75.2-1.42.3
Bone: trabecular spacing2.33.14.61.3-2.2
Bone: trabecular thickness0.50.61.10.01.1
Bone: trabecular tissue density0.30.50.7-0.80.5
Water consumed over 24 hours0.20.30.5-0.00.7
Number of responses in last shaping day0.40.50.6-0.60.8