LOC120102853

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	LOC120102853	0.06	0.06	3.1e-03	0.07	0.05	0.05	0.05	8.5e-04	2.9e-03	2.3e-03	2.5e-03
2	Brain	mRNA stability	LOC120102853	0.05	0.04	5.2e-05	0.04	0.04	0.03	0.03	3.1e-04	2.1e-04	1.0e-03	8.5e-04
3	PL	gene expression	LOC120102853	0.15	0.09	0.0e+00	0.17	0.18	0.18	0.18	5.0e-18	5.3e-19	1.7e-19	3.2e-19
4	Brain	alternative polyA	XR_005504708.1	0.04	0.03	1.0e-03	0.03	0.03	0.03	0.03	1.7e-03	1.2e-03	1.5e-03	1.2e-03
5	Brain	alternative polyA	XR_005504707.1	0.04	0.04	9.6e-04	0.03	0.03	0.03	0.03	1.5e-03	1.0e-03	1.3e-03	1.2e-03
6	Brain	isoform ratio	XR_005504707.1	0.03	0.03	3.5e-03	0.02	0.02	0.02	0.02	3.8e-03	3.4e-03	4.7e-03	3.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.4	1.1	-1.1	0.7	-0.6	-0.5	0.5	0.1
Area under the delay curve	0.0	0.0	0.1	0.3	-0.1	0.3	0.1	-0.1	-0.2
BMI with tail	3.1	10.2	11.3	-3.4	3.2	-3.2	-3.1	3.1	3.1
BMI without tail	3.3	6.7	7.8	-2.4	2.5	-2.6	-2.6	2.6	2.8
Body weight	6.2	25.9	26.9	-5.1	5.2	-5.2	-5.0	5.0	5.1
Weight adjusted by age	1.6	1.8	3.4	-1.8	1.5	-1.0	-1.3	1.3	0.8
Bone surface	0.9	1.6	3.2	-1.8	1.4	-1.3	-1.1	1.1	0.6
Bone volume	0.4	0.6	1.6	-1.3	0.9	-0.8	-0.6	0.6	0.3
Breakpoint value in progressive ratio session	0.2	0.2	0.4	-0.1	0.4	-0.4	-0.5	0.5	0.7
Number of licking bursts	0.4	0.4	0.7	0.5	-0.6	0.7	0.6	-0.6	-0.8
Context. condit. distance diff. score	0.8	1.0	1.1	0.9	-1.0	0.9	1.1	-1.1	-0.9
Locomotion velocity, session 1	0.0	0.0	0.1	0.4	-0.2	0.2	0.1	-0.1	-0.2
Locomotion distance, session 1	2.6	3.4	5.6	2.4	-2.0	1.7	1.7	-1.7	-1.4
Locomotion velocity, session 2	0.0	0.0	0.0	-0.1	0.0	-0.1	-0.0	0.0	-0.1
Locomotion distance, session 2	3.9	5.4	7.7	2.8	-2.5	2.2	2.2	-2.2	-1.8
Locomotion velocity, session 3	1.8	2.1	2.5	1.5	-1.6	1.4	1.5	-1.5	-1.2
Locomotion distance, session 3	3.1	3.3	3.7	1.9	-1.9	1.8	1.9	-1.9	-1.5
Stereotopy head waving bouts, day 3	0.6	0.7	0.9	-0.9	0.9	-0.8	-0.8	0.8	0.6
Stereotopy head waving duration, day 3	1.4	1.6	2.0	-1.4	1.4	-1.3	-1.3	1.3	1.0
Locomotion velocity, session 7	0.3	0.3	0.9	1.0	-0.7	0.4	0.5	-0.5	-0.1
Locomotion distance, session 7	1.6	2.0	3.6	1.9	-1.5	1.3	1.4	-1.3	-0.9
Stereotopy head waving bouts, day 7	0.4	0.5	0.5	-0.7	0.7	-0.7	-0.7	0.7	0.6
Stereotopy head waving duration, day 7	1.9	2.3	3.0	-1.7	1.6	-1.5	-1.5	1.5	1.3
Locomotion velocity, session 8	3.6	4.3	5.9	2.4	-2.2	2.0	2.0	-2.0	-1.7
Locomotion distance, session 8	5.9	8.6	10.1	3.2	-3.1	2.9	2.9	-2.9	-2.6
Degree of sensitization distance	0.5	0.5	0.6	-0.4	0.7	-0.7	-0.8	0.8	0.8
Degree of sensitization stereotypy	0.3	0.3	0.5	-0.7	0.6	-0.5	-0.5	0.5	0.5
Conditioned locomotion	0.0	0.0	0.0	-0.2	0.1	0.0	-0.1	0.1	0.1
Cocaine response after cond. corrected	0.3	0.3	0.5	-0.6	0.6	-0.5	-0.5	0.5	0.7
Cocaine response after cond. not corrected	0.0	0.0	0.0	-0.1	0.0	0.2	0.1	-0.1	-0.1
Cocaine response before conditioning	0.3	0.4	1.1	0.4	-0.5	0.6	0.5	-0.5	-1.0
Saline control response	0.6	0.8	1.1	-1.1	1.0	-0.9	-0.9	0.9	0.4
Bone: connectivity density	0.5	0.8	1.9	-1.4	1.0	-0.8	-0.8	0.8	0.3
Bone: cortical apparent density	0.1	0.2	0.3	0.4	-0.4	0.5	0.3	-0.3	-0.5
Bone: cortical area	3.1	4.7	6.3	-2.5	2.3	-2.3	-2.0	2.0	1.7
Bone: cortical porosity	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.0	0.0	-0.1
Bone: cortical porosity	0.4	0.4	0.6	-0.8	0.7	-0.7	-0.6	0.6	0.5
Bone: cortical thickness	0.6	1.1	1.8	-1.4	1.1	-1.1	-0.9	0.9	0.7
Bone: cortical thickness	0.1	0.1	0.4	-0.6	0.4	-0.2	-0.2	0.2	-0.1
Bone: cortical tissue density	0.1	0.2	0.3	0.4	-0.4	0.5	0.3	-0.3	-0.5
Condit. Reinf. active minus inactive responses	2.4	2.7	3.6	1.9	-1.7	1.6	1.6	-1.6	-1.4
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.7	1.0	-1.1	1.3	1.2	-1.2	-1.3
Condit. Reinf. active responses	1.1	1.4	2.1	1.4	-1.2	1.0	1.1	-1.1	-0.9
Condit. Reinf. inactive responses	0.1	0.1	0.5	0.7	-0.4	-0.0	0.2	-0.2	0.1
Incentive salience index mean	0.7	0.8	1.5	1.2	-1.0	0.8	0.8	-0.8	-0.6
Condit. Reinf. lever presses	0.1	0.1	0.2	0.3	0.1	-0.3	-0.2	0.2	0.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	-0.6	0.4	0.0	-0.1	0.1	-0.5
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.1	0.1	0.2	-0.0	0.0	-0.2
Condit. Reinf. active responses	0.2	0.2	0.7	-0.8	0.5	-0.1	-0.2	0.2	-0.5
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.6	0.4	-0.2	-0.1	0.1	-0.4
Condit. Reinf. lever presses	0.8	1.0	2.0	-1.4	1.2	-0.9	-0.9	0.9	0.5
Condit. Reinf. lever reinforcers received	0.3	0.5	1.2	-1.1	0.9	-0.5	-0.6	0.6	-0.1
Conditioned reinforcement - actives	0.1	0.1	0.4	-0.0	0.2	-0.4	-0.2	0.2	0.6
Conditioned reinforcement - inactives	0.8	0.9	2.9	-0.2	0.4	-1.1	-0.6	0.6	1.7
Conditioned locomotion	0.8	1.0	1.9	-0.5	0.9	-1.2	-0.9	0.9	1.4
Patch foraging indifference point 0 sec	0.2	0.3	0.5	-0.7	0.6	-0.6	-0.5	0.5	0.3
Patch foraging indifference point AUC	1.3	1.4	1.7	-1.1	1.3	-1.2	-1.3	1.3	1.1
Delay disc. indifference point, 0s delay	1.1	1.2	1.9	0.8	-1.0	1.3	1.1	-1.1	-1.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.1	0.3	-0.3	-0.3	0.3	0.2
Delay disc. indifference point, 2s delay	0.2	0.2	0.7	-0.0	-0.1	0.7	0.3	-0.3	-0.8
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	0.4	-0.2	0.3	0.2	-0.2	-0.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.6	-0.5	0.5	0.4	-0.4	-0.0
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.2	-0.1	0.4	0.1	-0.1	-0.5
Indifference point function ln k	0.2	0.3	0.4	0.4	-0.6	0.4	0.6	-0.6	-0.3
Indifference point function log k	0.2	0.3	0.4	0.4	-0.6	0.4	0.6	-0.6	-0.3
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.6	0.5	-0.3	-0.3	0.3	0.1
Patch foraging total patch changes 12 sec	2.1	2.7	3.1	-1.3	1.7	-1.6	-1.8	1.8	1.7
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	-0.5	0.4	-0.1	-0.3	0.3	-0.1
Patch foraging total patch changes 24 sec	1.0	1.3	1.7	-0.9	1.3	-1.1	-1.2	1.2	1.0
Patch foraging total patch changes 6 sec	0.8	1.2	1.4	-1.0	1.2	-1.1	-1.2	1.2	0.9
Patch foraging time to switch 0 sec	1.4	2.2	3.1	1.8	-1.6	1.4	1.5	-1.5	-1.1
Patch foraging water rate 0 sec	1.4	2.2	2.4	-1.5	1.5	-1.4	-1.5	1.5	1.3
Patch foraging water rate 12 sec	0.0	0.0	0.1	-0.4	0.1	0.0	0.1	-0.1	0.0
Patch foraging water rate 18 sec	0.0	0.0	0.1	0.0	-0.0	0.3	0.1	-0.1	-0.3
Patch foraging water rate 24 sec	0.0	0.1	0.3	-0.1	0.0	-0.2	-0.1	0.1	0.6
Patch foraging water rate 6 sec	0.2	0.3	0.4	-0.6	0.6	-0.6	-0.4	0.4	0.6
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.3	0.3	-0.3	-0.3	0.3	0.4
Distance traveled before self-admin	0.1	0.1	0.3	-0.5	0.4	-0.1	-0.3	0.3	0.3
Distance traveled after self-admin	0.0	0.0	0.1	-0.2	-0.0	0.3	-0.0	0.0	-0.3
Extensor digitorum longus weight	4.3	16.8	17.7	-4.2	4.2	-4.1	-4.1	4.1	3.9
Bone: elastic displacement	0.1	0.1	0.3	0.2	-0.0	-0.1	-0.2	0.3	0.6
Bone: elastic work	3.7	4.8	7.0	-1.7	1.9	-2.2	-2.2	2.2	2.7
Bone: endosteal estimation	4.0	8.8	9.9	-3.1	3.1	-2.9	-3.0	3.0	2.7
Bone: endosteal perimeter	3.1	6.5	7.0	-2.5	2.6	-2.6	-2.6	2.6	2.4
Epididymis fat weight	0.0	0.0	0.1	0.1	-0.2	0.1	0.3	-0.3	-0.1
Delta time in closed arm before/after self-admin	1.2	1.2	2.1	0.6	-0.9	1.1	1.2	-1.2	-1.5
Delta time in open arm before/after self-admin	0.6	0.6	1.4	0.2	0.5	-0.8	-0.8	0.8	1.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.0	-0.1	-0.3	-0.1	0.1	0.5
Delay discount exponential model param	0.0	0.0	0.1	-0.3	0.1	-0.3	-0.1	0.1	0.2
Extinction: sum of active levers before priming	0.5	0.5	1.9	1.4	-0.6	0.6	0.4	-0.4	-0.3
Active lever presses in extinction session 6	0.4	0.4	0.4	0.7	-0.7	0.7	0.5	-0.5	-0.6
Bone: final force	2.3	3.7	4.7	-2.2	2.1	-2.0	-1.9	1.9	1.6
Bone: final moment	3.4	5.5	6.5	-2.5	2.4	-2.4	-2.3	2.3	2.1
Food consumed during 24 hour testing period	1.7	2.0	2.2	-1.5	1.4	-1.4	-1.4	1.4	1.4
Glucose	0.0	0.0	0.0	0.2	-0.0	0.1	0.0	-0.0	-0.0
Heart weight	1.0	1.4	2.0	-0.9	1.1	-1.3	-1.1	1.1	1.4
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.3	0.1	-0.3	-0.1	0.1	0.2
Intermittent access intake day 1-15 change	4.2	4.2	5.5	2.3	-2.1	2.0	2.1	-2.1	-1.6
Intermittent access intake escalation	3.2	3.2	4.3	2.1	-1.8	1.7	1.8	-1.8	-1.4
Intermittent access intake escalation 2	1.6	1.6	2.1	1.4	-1.2	1.3	1.2	-1.2	-1.1
Intermitt. access day 1 inactive lever presses	1.4	1.5	1.8	1.2	-1.3	1.2	1.3	-1.3	-1.1
Intermitt. access day 15 inactive lever presses	1.9	2.1	3.3	1.8	-1.6	1.1	1.6	-1.6	-0.9
Intermitt. access escalation Index	0.1	0.1	0.5	0.0	0.0	-0.4	-0.1	0.1	0.7
Intermittent access day 1 total infusions	2.8	3.3	3.6	-1.6	1.8	-1.9	-1.8	1.8	1.9
Intermittent access day 15 total infusions	0.2	0.2	0.4	-0.2	0.3	-0.5	-0.4	0.4	0.7
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	0.1	0.0	-0.1	-0.1	0.1	0.2
Intermittent access total infusions	2.0	2.2	2.7	-1.3	1.4	-1.5	-1.5	1.5	1.6
Intermittent access day 1 locomotion	1.2	1.3	1.9	-1.0	0.9	-1.3	-1.0	1.0	1.4
Intermittent access day 15 total locomotion	0.7	0.7	1.7	-0.3	0.6	-1.0	-0.8	0.8	1.3
Intermittent access total locomotion	1.1	1.3	2.2	-0.7	1.0	-1.2	-1.1	1.1	1.5
Intermittent access standard deviation	1.6	1.7	2.8	1.7	-1.3	1.1	1.4	-1.4	-0.8
Left kidney weight	2.6	7.3	9.5	-2.4	2.7	-2.7	-2.6	2.6	3.1
Right kidney weight	2.8	7.8	10.5	-2.5	2.7	-2.9	-2.7	2.7	3.2
Cocaine induced anxiety	0.5	0.5	1.0	0.2	-0.6	0.8	0.8	-0.8	-1.0
Post-drug Anxiety	0.0	0.0	0.1	-0.3	0.2	-0.1	-0.2	0.2	0.0
Baseline Anxiety	0.4	0.4	0.9	-0.2	0.5	-0.8	-0.7	0.7	0.9
Tail length	0.9	2.8	3.8	-1.3	1.6	-1.7	-1.7	1.7	1.9
Length with tail	2.4	8.7	9.4	-2.8	3.0	-3.1	-2.9	2.9	3.1
Length without tail	1.3	2.8	3.8	-1.9	1.8	-1.8	-1.5	1.5	1.4
Times rat made contact with spout	0.0	0.0	0.0	-0.1	0.0	-0.0	0.1	-0.1	0.1
Lifetime Intake	2.1	2.3	3.0	-1.3	1.4	-1.6	-1.5	1.5	1.7
Liver weight, left	0.1	0.1	0.2	0.3	-0.3	0.4	0.4	-0.4	-0.3
Liver weight, right	0.3	0.4	0.7	0.5	-0.5	0.8	0.7	-0.7	-0.7
Locomotor activity	0.5	0.8	1.0	1.0	-0.9	0.9	0.9	-0.9	-0.8
Locomotor testing distance	0.2	0.3	0.4	0.5	-0.6	0.6	0.6	-0.6	-0.6
Locomotor testing rearing	0.9	1.4	1.9	0.8	-1.1	1.3	1.2	-1.2	-1.4
Locomotion in novel chamber	1.5	1.9	2.3	-1.4	1.5	-1.2	-1.5	1.5	1.1
Locomotion in novel chamber post-restriction	0.3	0.4	1.4	-0.3	0.1	-0.7	-0.5	0.5	1.2
Fecal boli incidents, locomotor time 1	0.4	0.4	0.7	0.2	-0.4	0.8	0.6	-0.6	-0.8
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.2	0.1	-0.1	-0.3	0.3	0.3
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.0	-0.1	0.2	0.3	-0.3	-0.1
Bouts of movement, locomotor time 1	0.2	0.3	0.8	0.9	-0.6	0.3	0.4	-0.4	0.0
Total resting periods, locomotor time 1	0.1	0.2	0.4	0.7	-0.4	0.2	0.4	-0.4	-0.2
Rest time, locomotor task time 1	0.2	0.2	0.7	0.9	-0.6	0.2	0.4	-0.4	0.1
Distance moved, locomotor task time 1	0.1	0.2	0.5	-0.7	0.5	-0.1	-0.3	0.3	-0.0
Vertical activity count, locomotor time 1	0.1	0.1	0.3	0.0	-0.0	0.3	0.2	-0.2	-0.6
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.0	-1.0	0.9	-0.5	-0.6	0.6	0.5
Bouts of movement, locomotor time 2	0.7	0.7	1.1	-0.6	0.6	-1.1	-0.9	0.9	1.0
Total resting periods, locomotor time 2	0.6	0.7	1.2	-0.4	0.6	-1.1	-0.8	0.8	1.0
Rest time, locomotor task time 2	0.1	0.1	0.4	0.3	-0.1	-0.7	-0.2	0.2	0.4
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.1	-0.2	0.4	0.2	-0.2	-0.2
Vertical activity count, locomotor time 2	0.1	0.1	0.1	-0.3	0.3	0.0	-0.2	0.2	0.3
Light reinforcement 1	2.1	3.9	4.4	-1.7	1.9	-1.9	-2.1	2.1	2.1
Light reinforcement 2	1.4	1.9	2.5	-1.6	1.4	-1.5	-1.3	1.3	1.2
Bone: marrow area	4.1	8.8	10.1	-3.2	3.1	-2.9	-3.0	3.0	2.7
Bone: maximum diameter	3.3	6.0	7.0	-2.7	2.6	-2.5	-2.4	2.4	2.0
Bone: maximum force	3.2	5.4	6.9	-2.6	2.5	-2.5	-2.2	2.2	1.9
Bone: maximum moment	3.9	6.7	8.0	-2.8	2.7	-2.8	-2.5	2.5	2.2
Mean time between licks in bursts	0.6	0.8	1.1	-0.7	0.8	-0.9	-0.9	0.9	1.0
Mean num. licks in bursts	0.4	0.4	0.9	-0.5	0.5	-0.7	-0.6	0.6	0.9
Cd content in liver	0.3	0.3	0.5	-0.7	0.6	-0.5	-0.6	0.6	0.5
Co content in liver	0.3	0.3	0.5	-0.7	0.6	-0.3	-0.6	0.6	0.4
Cu content in liver	0.5	0.6	0.7	0.8	-0.7	0.7	0.8	-0.8	-0.8
Fe content in liver	0.1	0.1	0.2	-0.3	0.4	-0.4	-0.4	0.4	0.4
K content in liver	2.4	2.4	2.6	1.5	-1.5	1.6	1.5	-1.5	-1.6
Mg content in liver	0.4	0.4	0.5	0.5	-0.6	0.6	0.6	-0.6	-0.7
Mn content in liver	0.0	0.0	0.1	-0.3	0.2	-0.2	-0.1	0.1	0.1
Na content in liver	3.2	3.4	4.1	1.7	-1.8	1.8	1.9	-1.9	-2.0
Rb content in liver	0.9	1.2	1.9	0.8	-0.9	1.1	1.1	-1.1	-1.4
Se content in liver	4.9	6.1	7.4	2.1	-2.3	2.6	2.5	-2.5	-2.7
Sr content in liver	5.1	4.7	4.9	2.2	-2.2	2.2	2.2	-2.2	-2.1
Zn content in liver	0.2	0.2	0.4	-0.6	0.6	-0.3	-0.5	0.5	0.3
Bone: minimum diameter	1.6	3.0	3.6	-1.9	1.8	-1.9	-1.6	1.6	1.5
Time in familiar zone, hab. session 1	1.6	1.5	1.7	-0.9	1.2	-1.3	-1.3	1.3	1.3
Time in novel zone, hab. session 1	5.6	5.5	6.3	2.0	-2.3	2.5	2.4	-2.4	-2.4
Total zone transitions, hab. session 1	7.9	11.1	15.3	3.9	-3.6	3.1	3.3	-3.3	-2.6
Total locomotion distance, hab. session 1	5.9	8.4	9.8	3.1	-3.1	2.7	2.9	-2.9	-2.6
Locomotion velocity, hab. session 1	4.0	5.7	6.9	2.6	-2.5	2.2	2.4	-2.4	-2.1
Time in familiar zone, hab. session 2	0.3	0.3	0.7	-0.1	0.3	-0.6	-0.6	0.6	0.8
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.0	-0.2	0.4	0.3	-0.3	-0.5
Total zone transitions, hab. session 2	2.9	3.7	6.6	2.6	-2.1	1.7	1.8	-1.8	-1.3
Total locomotion distance, hab. session 2	0.9	1.2	1.8	1.3	-1.2	0.9	1.1	-1.1	-0.8
Locomotion velocity, hab. session 2	0.8	1.0	1.5	1.2	-1.1	0.9	1.0	-1.0	-0.9
Novel to familiar place preference ratio	0.1	0.1	0.3	0.1	-0.2	0.3	0.3	-0.3	-0.6
Novelty place preference	0.6	0.6	1.1	0.5	-0.6	0.8	0.8	-0.8	-1.0
Time in novel zone, NPP test	0.8	0.8	1.4	0.6	-0.7	0.9	0.9	-0.9	-1.2
Total zone transitions, NPP test	3.0	4.3	5.5	2.3	-2.1	2.0	2.0	-2.0	-1.9
Total locomotion distance, NPP test	0.6	0.8	0.9	0.9	-0.9	0.8	1.0	-1.0	-0.9
Locomotion velocity, NPP test	0.3	0.4	0.5	0.7	-0.7	0.5	0.7	-0.7	-0.5
Intraocular pressure	6.3	8.7	11.0	-2.5	2.6	-3.1	-3.0	3.1	3.3
Delta distance traveled before/after self-admin	0.2	0.2	0.4	0.4	-0.4	0.5	0.3	-0.3	-0.7
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	0.5	-0.5	0.4	0.4	-0.4	-0.7
Parametrial fat weight	0.6	1.1	1.7	1.3	-1.2	0.9	1.1	-1.1	-0.6
Pavlov. Cond. lever latency	0.8	1.0	2.2	0.3	-0.7	1.1	0.9	-0.9	-1.5
Pavlov. Cond. magazine entry latency	0.5	0.6	1.8	0.1	0.3	-0.7	-0.7	0.7	1.3
Pavlov. Cond. change in total contacts	0.2	0.2	0.6	0.8	-0.5	0.3	0.4	-0.4	-0.0
Pavlov. Cond. index score	0.7	0.9	2.6	-0.1	0.5	-1.0	-0.9	0.9	1.6
Pavlov. Cond. latency score	1.1	1.3	3.3	-0.3	0.7	-1.3	-1.1	1.1	1.8
Pavlov. Cond. lever contacts	1.3	1.5	3.4	-0.4	0.9	-1.3	-1.2	1.2	1.8
Pavlov. Cond. magazine entry number	1.0	1.2	2.9	0.3	-0.7	1.2	1.1	-1.1	-1.7
Pavlov. Cond. intertrial magazine entries	3.0	3.7	4.7	1.8	-1.8	2.0	1.9	-1.9	-2.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	2.0	0.1	0.4	-0.8	-0.7	0.7	1.4
Pavlov. Cond. response bias	0.8	1.0	2.5	-0.2	0.6	-1.1	-1.0	1.0	1.6
Pavlov. Cond. lever latency	0.1	0.2	0.4	0.7	-0.5	0.3	0.3	-0.3	-0.1
Pavlov. Cond. magazine entry latency	0.8	0.9	1.2	0.8	-0.9	1.0	1.0	-1.0	-1.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	-0.7	0.4	-0.2	-0.2	0.2	-0.0
Pavlov. Cond. index score	0.1	0.1	0.2	-0.1	-0.1	0.3	0.3	-0.3	-0.5
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.5	0.3	-0.2	-0.2	0.2	0.0
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.5	0.4	-0.0	-0.1	0.1	-0.1
Pavlov. Cond. magazine entry number	0.4	0.5	0.7	-0.5	0.7	-0.7	-0.8	0.8	0.9
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.2	-0.0	0.1	0.0	0.0	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.0	-0.2	0.4	0.4	-0.4	-0.6
Pavlov. Cond. response bias	0.2	0.2	0.6	0.1	-0.3	0.5	0.5	-0.5	-0.8
Time in closed arm before self-admin	4.8	5.4	7.3	-2.7	2.4	-2.2	-2.3	2.3	1.9
Time in closed arm after self-admin	1.0	1.0	2.2	-1.5	1.1	-0.9	-0.9	0.9	0.5
Time in open arm before self-admin	1.2	1.3	1.6	0.7	-1.0	1.1	1.2	-1.2	-1.3
Time in open arm after self-admin	0.3	0.3	1.1	1.0	-0.6	0.3	0.3	-0.3	0.2
Bone: periosteal estimation	4.7	9.7	11.9	-3.4	3.3	-3.2	-3.0	3.0	2.7
Bone: periosteal perimeter	6.0	10.0	10.8	-3.3	3.3	-3.3	-3.1	3.1	2.9
Bone: post-yield work	0.7	1.0	1.3	-1.2	1.1	-1.0	-1.0	1.0	0.8
Progressive ratio test 1 active lever presses	0.3	0.3	0.7	-0.2	0.4	-0.6	-0.5	0.5	0.8
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.0	0.2	-0.3	-0.2	0.2	0.5
Progressive ratio test 1 inactive lever presses	0.7	0.8	1.7	1.3	-1.0	0.6	0.9	-0.9	-0.0
Progressive ratio test 2 active lever presses	1.3	1.4	1.9	-0.9	1.2	-1.2	-1.3	1.3	1.4
Progressive ratio test 2 breakpoint	1.2	1.4	1.6	-0.9	1.2	-1.1	-1.2	1.2	1.3
Progressive ratio test 2 inactive lever presses	0.3	0.4	1.4	0.3	0.1	-0.7	-0.2	0.2	1.2
Incentive Sensitization - Responses	1.1	1.1	1.4	-0.7	1.0	-1.0	-1.2	1.2	1.1
Incentive Sensitization - Breakpoint	1.6	1.6	2.1	-1.0	1.3	-1.2	-1.4	1.4	1.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.3	0.4	-0.2	-0.5	0.5	0.3
Progressive ratio	1.4	1.6	2.9	-0.6	1.1	-1.3	-1.3	1.3	1.7
Food seeking constrained by brief footshock	5.0	6.1	9.4	-3.1	2.9	-2.0	-2.5	2.5	1.4
Seeking ratio, punishment vs. effort	0.3	0.4	1.3	-1.1	0.6	0.1	-0.2	0.2	-0.8
Retroperitoneal fat weight	0.9	3.1	3.3	1.7	-1.7	1.7	1.8	-1.8	-1.8
Reaction time number correct	0.4	0.6	0.8	-0.9	0.9	-0.7	-0.7	0.7	0.7
Reaction time mean minus median	0.8	1.1	1.6	1.3	-1.2	0.9	1.1	-1.1	-0.7
Reaction time mean minus median AUC	0.9	1.2	1.5	1.2	-1.1	1.0	1.1	-1.1	-0.9
Reaction time num false alarms	0.8	1.0	1.5	-1.0	1.0	-1.2	-1.0	1.0	1.0
Reaction time num false alarms AUC	0.9	1.3	1.6	-1.2	1.1	-1.3	-1.1	1.1	1.1
Reaction time trials correct on left	0.4	0.6	0.8	-0.9	0.9	-0.7	-0.7	0.7	0.7
Reaction time trials on left	0.5	0.7	1.0	-1.0	0.9	-0.8	-0.8	0.8	0.7
Reaction time mean	0.2	0.3	0.5	-0.3	0.5	-0.7	-0.6	0.6	0.6
Reaction time mean AUC	0.1	0.2	0.3	-0.2	0.4	-0.5	-0.4	0.4	0.4
Median of all reaction times	0.8	1.1	1.4	-0.8	1.1	-1.2	-1.1	1.1	1.0
Reaction time omissions	0.5	0.7	1.7	-1.3	0.9	-0.8	-0.7	0.7	0.1
Reaction time false alarm rate	0.1	0.2	0.3	-0.2	0.3	-0.6	-0.4	0.4	0.5
Reaction time premature initiation rate	0.1	0.2	0.2	-0.1	0.5	-0.3	-0.5	0.5	0.4
Reaction time premature initiations	0.7	1.0	1.2	-0.8	1.1	-0.9	-1.1	1.1	0.9
Std. dev. reaction times	0.4	0.6	0.7	0.8	-0.8	0.7	0.8	-0.8	-0.7
Reaction time trials completed	0.5	0.7	1.0	-1.0	0.9	-0.8	-0.8	0.8	0.7
Reaction time trials AUC	0.5	0.7	0.9	-0.9	0.9	-0.8	-0.8	0.8	0.7
Run reversals in cocaine runway, females	0.5	0.5	0.6	-0.8	0.7	-0.7	-0.7	0.7	0.6
Run reversals in cocaine runway, males	0.7	0.7	0.9	0.9	-0.8	0.8	0.8	-0.8	-0.5
Latency to leave start box in cocaine runway	0.9	0.9	1.3	-1.0	1.1	-0.7	-1.1	1.1	0.6
Latency to leave start box in cocaine runway, F	0.4	0.4	0.6	-0.7	0.8	-0.5	-0.7	0.7	0.5
Latency to leave start box in cocaine runway, M	0.3	0.3	0.5	-0.7	0.6	-0.3	-0.6	0.6	-0.2
Std. dev. time between licks in bursts	0.4	0.4	0.6	-0.8	0.7	-0.7	-0.6	0.6	0.6
Total sessions with >9 infusions	0.7	0.7	2.2	-0.4	0.4	-1.0	-0.7	0.7	1.5
Short access day 1 total inactive lever presses	0.2	0.2	0.7	0.4	-0.2	-0.4	-0.1	0.1	0.8
Short access day 10 total inactive lever presses	1.1	1.2	1.6	1.2	-1.2	1.0	1.2	-1.2	-0.8
Short access day 1 total infusions	0.2	0.2	0.4	0.5	-0.6	0.2	0.5	-0.5	0.0
Short access day 10 total infusions	0.6	0.7	0.8	-0.9	0.8	-0.9	-0.7	0.7	0.9
Short access total infusions	0.8	0.9	1.6	-0.7	0.7	-1.1	-0.8	0.8	1.3
Short access day 1 locomotion	0.1	0.1	0.3	-0.1	-0.3	-0.3	0.2	-0.2	0.6
Short access day 10 total locomotion	0.5	0.6	0.9	-0.7	0.6	-0.9	-0.6	0.6	0.9
Short access total locomotion	0.2	0.2	0.8	-0.3	0.1	-0.6	-0.2	0.2	0.9
One hour access (0.3 mA shock)	0.4	0.5	1.1	-0.3	0.6	-0.8	-0.6	0.6	1.0
Compulsive drug intake	0.1	0.1	0.3	0.6	-0.3	0.1	0.3	-0.3	-0.1
One hour access (shock baseline)	0.6	0.7	0.8	-0.8	0.8	-0.8	-0.7	0.7	0.9
Social response proportion	1.9	2.1	2.4	1.5	-1.5	1.3	1.5	-1.5	-1.3
Social responses	0.4	0.5	0.9	0.2	-0.5	0.7	0.8	-0.8	-1.0
Social time	0.1	0.2	0.3	0.4	-0.4	0.4	0.5	-0.5	-0.3
Soleus weight	1.5	4.4	4.8	-2.2	2.2	-2.1	-2.1	2.1	2.0
Bone: stiffness	0.1	0.2	0.6	-0.8	0.5	-0.5	-0.2	0.2	-0.2
Tibialis anterior weight	6.5	22.2	23.6	-4.9	4.9	-4.7	-4.7	4.7	4.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.4	0.2	-0.4	-0.4	0.4	0.2
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.1	-0.0	0.2	0.2	-0.2	-0.2
Time to tail flick, test, before self-admin	4.8	4.7	5.2	-2.2	2.0	-2.3	-2.1	2.1	2.3
Time to tail flick, test, after self-admin	0.4	0.5	0.6	-0.6	0.6	-0.6	-0.8	0.8	0.7
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	0.1	-0.2	0.6	0.4	-0.4	-0.6
Delta time to tail flick, test, before/after SA	1.3	1.2	1.6	1.3	-1.1	1.0	1.1	-1.1	-0.9
Tibia length	1.5	4.3	4.9	-2.0	2.1	-2.2	-2.1	2.1	2.1
Ambulatory time before self-admin	0.0	0.0	0.1	-0.1	-0.0	0.3	-0.0	0.0	-0.1
Ambulatory time after self-admin	0.1	0.1	0.1	-0.3	0.2	0.0	-0.3	0.3	-0.1
Bone: tissue strength	0.5	0.5	0.6	0.8	-0.8	0.6	0.7	-0.7	-0.6
Total heroin consumption	0.3	0.4	0.9	0.3	0.4	-0.5	-0.6	0.6	1.0
Bone: trabecular number	0.1	0.1	0.5	-0.7	0.3	-0.1	-0.0	0.0	-0.4
Bone: trabecular spacing	0.7	0.9	1.2	-0.8	0.9	-0.9	-1.0	1.0	1.1
Bone: trabecular thickness	0.0	0.0	0.1	-0.3	0.1	-0.2	0.0	-0.0	-0.1
Bone: trabecular tissue density	5.9	8.3	10.3	2.6	-2.8	2.8	2.9	-2.9	-3.2
Water consumed over 24 hours	1.4	1.7	2.0	-1.4	1.3	-1.3	-1.3	1.3	1.2
Number of responses in last shaping day	0.2	0.2	0.4	-0.6	-0.1	0.2	0.3	-0.3	-0.7