LOC120101075

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC120101075	0.04	0.03	2.7e-04	0.03	0.04	0.03	0.03	5.0e-04	2.4e-04	9.7e-04	1.8e-03
2	Adipose	mRNA stability	LOC120101075	0.1	0.06	4.7e-10	0.06	0.07	0.08	0.08	9.0e-08	2.2e-08	3.1e-09	5.6e-09
3	OFC	alternative TSS	XR_005501454.1	0.47	0.16	6.9e-05	-0	0.01	0.04	0.01	3.6e-01	1.9e-01	5.2e-02	2.2e-01
4	OFC	alternative TSS	XR_005501454.1	0.51	0.16	2.4e-05	0.09	0.02	0.1	0.05	3.2e-03	1.1e-01	3.0e-03	2.9e-02
5	OFC	alternative TSS	XR_005501453.1	0.33	0.16	8.3e-03	0.1	0	0.04	0.09	2.2e-03	3.2e-01	4.4e-02	3.6e-03
6	OFC	alternative TSS	XR_005501453.1	0.34	0.16	5.6e-03	0.1	-0	-0	0.09	2.0e-03	3.4e-01	3.5e-01	3.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.3	2.2	3.3	1.3	-1.3	1.8	1.8	-1.3	-1.3
Area under the delay curve	0.8	0.9	1.1	-0.8	1.0	-1.0	-1.0	0.9	0.9
BMI with tail	2.0	6.6	8.5	2.7	-2.4	2.9	2.8	-2.2	-2.2
BMI without tail	0.2	0.5	1.4	1.2	-0.9	0.5	0.5	-0.1	-0.1
Body weight	0.3	1.4	4.6	-1.8	2.1	-0.2	-0.3	-0.5	-0.5
Weight adjusted by age	0.6	0.7	1.6	-1.3	1.1	-0.7	-0.7	0.3	0.3
Bone surface	2.8	5.0	7.2	0.9	-1.4	2.6	2.7	-2.6	-2.6
Bone volume	1.6	2.7	4.0	1.1	-1.4	2.0	2.0	-1.6	-1.6
Breakpoint value in progressive ratio session	1.2	1.4	2.6	1.5	-1.6	1.1	1.1	-0.6	-0.6
Number of licking bursts	2.6	3.1	5.3	2.0	-2.3	1.8	1.7	-1.2	-1.2
Context. condit. distance diff. score	0.3	0.4	1.3	-1.0	1.1	-0.3	-0.1	-0.0	-0.0
Locomotion velocity, session 1	0.9	1.0	1.6	-0.5	0.6	-1.3	-1.3	1.0	1.0
Locomotion distance, session 1	0.2	0.2	0.4	-0.6	0.5	-0.5	-0.4	0.2	0.2
Locomotion velocity, session 2	3.3	3.9	5.6	-1.7	2.0	-2.2	-2.4	1.7	1.7
Locomotion distance, session 2	0.6	0.8	1.1	-0.3	0.6	-1.0	-1.1	1.0	1.0
Locomotion velocity, session 3	2.6	3.0	5.3	-1.9	2.3	-1.8	-1.9	1.1	1.1
Locomotion distance, session 3	1.7	1.8	4.9	-2.2	2.2	-0.9	-0.8	0.1	0.1
Stereotopy head waving bouts, day 3	0.8	0.9	1.3	-0.8	0.8	-1.1	-1.1	1.0	1.0
Stereotopy head waving duration, day 3	0.2	0.3	0.6	-0.1	0.2	-0.7	-0.7	0.6	0.6
Locomotion velocity, session 7	0.4	0.4	1.2	-1.0	1.1	-0.2	-0.3	-0.3	-0.3
Locomotion distance, session 7	0.4	0.5	1.8	-0.9	1.4	-0.2	-0.2	-0.3	-0.3
Stereotopy head waving bouts, day 7	0.4	0.5	1.4	0.9	-1.2	0.5	0.6	-0.3	-0.3
Stereotopy head waving duration, day 7	0.1	0.1	0.3	0.3	-0.6	-0.0	-0.0	0.0	0.0
Locomotion velocity, session 8	4.3	5.2	7.1	-1.6	2.1	-2.7	-2.7	2.2	2.2
Locomotion distance, session 8	0.9	1.4	3.4	-1.6	1.8	-1.0	-0.9	0.4	0.4
Degree of sensitization distance	0.2	0.2	0.9	0.9	-0.5	0.2	0.0	0.1	0.1
Degree of sensitization stereotypy	0.6	0.6	1.6	1.0	-1.3	0.6	0.7	-0.3	-0.3
Conditioned locomotion	0.6	0.7	1.1	0.3	-0.6	1.0	0.9	-1.0	-1.0
Cocaine response after cond. corrected	1.1	1.2	3.2	-1.8	1.4	0.3	0.1	-1.1	-1.1
Cocaine response after cond. not corrected	1.2	1.3	4.0	-2.0	1.7	-0.2	-0.3	-0.7	-0.7
Cocaine response before conditioning	0.7	0.9	1.2	-0.2	0.7	-1.1	-1.1	1.1	1.1
Saline control response	0.1	0.2	0.6	-0.7	0.6	-0.1	0.0	-0.0	-0.0
Bone: connectivity density	2.3	3.6	5.7	0.2	-0.5	2.2	2.2	-2.4	-2.4
Bone: cortical apparent density	0.6	0.8	0.9	-0.7	0.9	-1.0	-0.9	0.9	0.9
Bone: cortical area	0.4	0.5	1.0	-0.4	0.2	0.7	0.7	-1.0	-1.0
Bone: cortical porosity	0.4	0.5	1.4	1.1	-1.2	0.4	0.3	0.0	0.0
Bone: cortical porosity	0.4	0.4	1.3	1.0	-1.1	0.3	0.3	0.1	0.1
Bone: cortical thickness	0.2	0.4	0.7	-0.9	0.6	0.3	0.3	-0.7	-0.7
Bone: cortical thickness	1.3	1.5	2.1	-1.4	1.1	0.9	0.9	-1.4	-1.4
Bone: cortical tissue density	0.6	0.7	0.9	-0.7	0.9	-0.9	-0.9	0.8	0.8
Condit. Reinf. active minus inactive responses	0.8	0.9	2.5	1.6	-1.5	0.5	0.4	0.1	0.1
Condit. Reinf. active-inactive response ratio	1.1	1.2	3.3	1.8	-1.8	0.6	0.5	0.0	0.0
Condit. Reinf. active responses	0.1	0.1	0.3	0.6	-0.5	-0.0	-0.1	0.2	0.2
Condit. Reinf. inactive responses	1.0	1.2	2.3	-1.5	1.5	-1.0	-1.0	0.5	0.5
Incentive salience index mean	0.7	0.8	2.3	1.5	-1.5	0.1	-0.0	0.5	0.5
Condit. Reinf. lever presses	0.2	0.2	0.9	0.7	-1.0	0.1	0.0	0.2	0.2
Condit. Reinf. active minus inactive responses	3.9	4.8	6.3	-1.7	2.0	-2.5	-2.4	2.2	2.2
Condit. Reinf. active-inactive response ratio	3.6	3.7	5.0	-1.2	1.6	-2.2	-2.2	2.1	2.1
Condit. Reinf. active responses	1.5	2.1	2.9	-1.0	1.0	-1.7	-1.6	1.6	1.6
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.1	-0.2	0.1	0.2	-0.2	-0.2
Condit. Reinf. lever presses	0.8	1.1	1.6	-1.2	1.3	-1.1	-1.1	0.8	0.8
Condit. Reinf. lever reinforcers received	1.6	2.2	2.9	-1.2	1.1	-1.7	-1.7	1.5	1.5
Conditioned reinforcement - actives	1.0	1.0	1.9	-0.8	0.3	0.9	0.9	-1.4	-1.4
Conditioned reinforcement - inactives	0.7	0.8	1.4	-0.8	0.7	0.7	0.7	-1.2	-1.2
Conditioned locomotion	0.5	0.6	0.9	-0.7	0.7	0.6	0.5	-0.9	-0.9
Patch foraging indifference point 0 sec	1.2	1.9	4.3	-2.1	1.8	0.3	0.3	-1.3	-1.3
Patch foraging indifference point AUC	0.4	0.5	1.3	0.9	-1.2	-0.1	0.0	0.5	0.5
Delay disc. indifference point, 0s delay	1.6	1.7	2.7	-0.2	0.7	-1.5	-1.5	1.6	1.6
Delay disc. indifference point, 16s delay	0.2	0.2	0.5	-0.7	0.5	-0.0	-0.0	-0.3	-0.3
Delay disc. indifference point, 2s delay	0.9	1.0	1.4	-0.8	0.9	-1.2	-1.1	1.0	1.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.4	0.1	-0.3	-0.3	0.3	0.3
Delay disc. indifference point, 4s delay	1.3	1.4	1.8	-0.6	1.1	-1.3	-1.2	1.3	1.3
Delay disc. indifference point, 8s delay	0.4	0.4	0.6	-0.2	0.4	-0.7	-0.6	0.8	0.8
Indifference point function ln k	0.8	1.1	2.4	-1.5	1.6	-0.9	-0.9	0.4	0.4
Indifference point function log k	0.8	1.1	2.4	-1.5	1.6	-0.9	-0.9	0.4	0.4
Patch foraging total patch changes 0 sec	1.4	2.2	5.6	-2.4	2.1	0.2	0.2	-1.3	-1.3
Patch foraging total patch changes 12 sec	0.5	0.6	0.9	0.2	-0.4	0.9	0.9	-0.9	-0.9
Patch foraging total patch changes 18 sec	0.9	1.1	1.9	0.1	-0.2	1.2	1.2	-1.4	-1.4
Patch foraging total patch changes 24 sec	0.2	0.3	0.4	-0.6	0.5	0.3	0.4	-0.6	-0.6
Patch foraging total patch changes 6 sec	0.4	0.7	1.2	-1.1	0.8	0.4	0.5	-0.9	-0.9
Patch foraging time to switch 0 sec	2.3	3.6	7.9	2.8	-2.4	1.8	1.8	-0.8	-0.8
Patch foraging water rate 0 sec	1.2	2.0	6.2	-2.5	1.9	-1.0	-1.0	0.1	0.1
Patch foraging water rate 12 sec	1.4	2.1	7.3	-2.7	1.9	-0.4	-0.4	-0.8	-0.8
Patch foraging water rate 18 sec	1.8	2.5	6.8	-2.6	2.3	-1.2	-1.1	0.2	0.2
Patch foraging water rate 24 sec	2.5	3.5	5.9	-2.2	1.2	1.2	1.3	-2.4	-2.4
Patch foraging water rate 6 sec	5.0	7.3	17.9	-4.2	4.0	-2.1	-2.1	0.6	0.6
Seeking ratio, delayed vs. immediate footshock	5.1	5.9	7.6	1.3	-2.0	2.7	2.8	-2.7	-2.7
Distance traveled before self-admin	0.9	1.0	2.7	-1.6	0.7	0.3	0.2	-1.2	-1.2
Distance traveled after self-admin	0.5	0.6	2.0	-1.4	1.0	-0.1	-0.2	-0.5	-0.5
Extensor digitorum longus weight	2.5	9.9	15.3	3.8	-3.9	3.3	3.3	-2.0	-2.0
Bone: elastic displacement	0.4	0.5	0.8	0.8	-0.4	-0.5	-0.5	0.9	0.9
Bone: elastic work	0.4	0.5	0.8	0.7	-0.9	0.8	0.8	-0.4	-0.4
Bone: endosteal estimation	0.1	0.1	0.2	-0.0	-0.3	0.4	0.4	-0.4	-0.4
Bone: endosteal perimeter	0.4	0.8	1.4	0.7	-0.8	1.1	1.2	-0.8	-0.8
Epididymis fat weight	0.6	1.4	2.5	-0.3	0.2	1.2	1.2	-1.6	-1.6
Delta time in closed arm before/after self-admin	3.6	3.5	9.7	3.1	-2.8	1.4	1.3	-0.3	-0.3
Delta time in open arm before/after self-admin	0.2	0.2	0.6	-0.8	0.4	0.1	0.2	-0.3	-0.3
Diff in mean of infusions in LGA sessions	0.5	0.6	1.0	0.0	-0.2	-0.8	-0.9	1.0	1.0
Delay discount exponential model param	0.8	0.8	1.1	0.8	-1.0	1.0	0.9	-0.9	-0.9
Extinction: sum of active levers before priming	1.6	1.6	2.2	1.0	-1.3	1.5	1.4	-1.2	-1.2
Active lever presses in extinction session 6	1.2	1.2	1.6	0.6	-1.1	1.2	1.3	-1.1	-1.1
Bone: final force	0.0	0.1	0.2	-0.3	0.5	0.1	0.1	-0.2	-0.2
Bone: final moment	0.1	0.1	0.2	-0.5	0.5	0.2	0.2	-0.4	-0.4
Food consumed during 24 hour testing period	0.4	0.5	1.1	-1.0	1.0	-0.6	-0.6	0.2	0.2
Glucose	0.1	0.2	0.3	0.3	-0.1	-0.4	-0.4	0.6	0.6
Heart weight	0.4	0.6	1.9	1.4	-1.1	0.5	0.5	-0.0	-0.0
Delay discount hyperbolic model param	0.9	1.0	1.4	0.9	-1.2	1.1	1.0	-0.9	-0.9
Intermittent access intake day 1-15 change	0.2	0.2	0.3	-0.6	0.4	0.2	0.2	-0.5	-0.5
Intermittent access intake escalation	0.4	0.3	0.8	-0.9	0.8	0.1	0.1	-0.6	-0.6
Intermittent access intake escalation 2	0.4	0.4	0.8	-0.2	0.3	0.7	0.6	-0.9	-0.9
Intermitt. access day 1 inactive lever presses	1.7	1.8	2.7	1.6	-1.6	1.4	1.4	-0.9	-0.9
Intermitt. access day 15 inactive lever presses	1.5	1.6	2.2	1.2	-1.0	1.5	1.5	-1.2	-1.2
Intermitt. access escalation Index	0.5	0.5	0.7	-0.4	0.2	-0.8	-0.9	0.8	0.8
Intermittent access day 1 total infusions	0.9	1.0	1.9	-1.0	0.5	0.8	0.8	-1.4	-1.4
Intermittent access day 15 total infusions	1.1	1.3	2.6	-1.6	1.2	0.5	0.4	-1.3	-1.3
Intermittent access terminal intake (last 3 days)	1.0	1.1	1.8	-1.1	0.9	0.7	0.7	-1.3	-1.3
Intermittent access total infusions	1.1	1.3	2.6	-1.6	1.2	0.5	0.4	-1.2	-1.2
Intermittent access day 1 locomotion	0.9	0.9	2.4	-1.6	1.4	-0.7	-0.8	0.2	0.2
Intermittent access day 15 total locomotion	1.2	1.3	4.1	-2.0	1.7	-0.3	-0.3	-0.6	-0.6
Intermittent access total locomotion	1.5	1.7	5.5	-2.3	1.9	-0.4	-0.5	-0.5	-0.5
Intermittent access standard deviation	0.2	0.2	0.9	0.9	-0.2	0.2	0.1	0.3	0.3
Left kidney weight	0.3	0.9	1.4	-1.2	1.1	0.5	0.4	-1.0	-1.0
Right kidney weight	0.5	1.3	2.4	-0.5	0.6	1.1	1.1	-1.6	-1.6
Cocaine induced anxiety	0.4	0.4	1.3	-1.1	0.8	-0.6	-0.6	0.1	0.1
Post-drug Anxiety	0.9	1.0	1.8	-1.3	1.2	-1.1	-1.0	0.6	0.6
Baseline Anxiety	1.6	1.7	3.0	0.2	0.2	-1.4	-1.4	1.7	1.7
Tail length	3.4	10.4	21.8	-4.7	4.4	-3.0	-2.9	1.4	1.4
Length with tail	4.4	15.9	36.0	-6.0	5.8	-3.3	-3.4	1.2	1.2
Length without tail	2.1	4.6	12.0	-3.5	3.4	-1.4	-1.5	0.1	0.1
Times rat made contact with spout	0.2	0.2	0.7	0.8	-0.5	0.4	0.5	-0.1	-0.1
Lifetime Intake	1.4	1.6	2.9	-1.7	1.2	0.6	0.6	-1.5	-1.5
Liver weight, left	0.9	1.4	3.9	-2.0	1.8	-0.0	0.1	-0.8	-0.8
Liver weight, right	0.3	0.5	0.8	-0.3	0.2	0.8	0.9	-0.9	-0.9
Locomotor activity	0.1	0.1	0.3	0.4	-0.5	-0.1	-0.2	0.3	0.3
Locomotor testing distance	0.5	0.9	2.4	1.5	-1.5	0.6	0.5	0.1	0.1
Locomotor testing rearing	1.1	1.7	2.4	0.6	-1.2	1.6	1.5	-1.4	-1.4
Locomotion in novel chamber	1.2	1.5	3.1	1.7	-1.8	1.1	1.0	-0.5	-0.5
Locomotion in novel chamber post-restriction	0.2	0.3	0.9	0.9	0.2	-0.3	-0.2	0.6	0.6
Fecal boli incidents, locomotor time 1	1.8	2.0	3.7	1.6	-1.9	1.4	1.6	-0.7	-0.7
Change in fecal boli incidents, locomotor task	1.6	1.5	2.6	-0.3	-0.2	1.3	1.4	-1.6	-1.6
Time >=10cm from walls, locomotor time 1	5.5	5.5	8.7	1.2	-2.0	2.8	2.9	-2.4	-2.4
Bouts of movement, locomotor time 1	0.6	0.6	1.1	0.7	-0.5	-0.7	-0.7	1.0	1.0
Total resting periods, locomotor time 1	0.4	0.5	0.8	0.7	-0.4	-0.5	-0.5	0.9	0.9
Rest time, locomotor task time 1	1.8	1.9	3.3	1.8	-1.8	1.4	1.3	-0.9	-0.9
Distance moved, locomotor task time 1	0.5	0.6	1.9	-1.4	1.1	-0.4	-0.3	-0.1	-0.1
Vertical activity count, locomotor time 1	2.0	2.1	2.9	-1.6	1.7	-1.5	-1.4	1.1	1.1
Time >=10cm from walls, locomotor time 2	3.3	3.5	4.9	1.2	-1.4	2.1	2.2	-2.0	-2.0
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.1	-0.2	0.4	0.5	-0.5	-0.5
Total resting periods, locomotor time 2	0.2	0.2	0.3	0.4	-0.6	0.5	0.5	-0.4	-0.4
Rest time, locomotor task time 2	1.9	2.2	5.0	2.1	-2.2	1.3	1.2	-0.5	-0.5
Distance moved, locomotor task time 2	0.5	0.6	1.9	-1.4	1.2	-0.3	-0.2	-0.1	-0.1
Vertical activity count, locomotor time 2	0.7	0.8	2.0	-1.1	1.4	-0.8	-0.7	0.5	0.5
Light reinforcement 1	1.6	3.0	3.8	-1.7	1.7	-2.0	-1.9	1.5	1.5
Light reinforcement 2	0.1	0.1	0.5	0.4	-0.7	0.2	0.2	-0.1	-0.1
Bone: marrow area	0.1	0.2	0.2	0.0	-0.3	0.5	0.5	-0.5	-0.5
Bone: maximum diameter	1.4	2.6	4.0	1.0	-1.2	1.9	2.0	-1.7	-1.7
Bone: maximum force	0.1	0.2	0.2	0.3	-0.3	0.5	0.5	-0.4	-0.4
Bone: maximum moment	0.1	0.2	0.3	0.1	-0.3	0.5	0.6	-0.5	-0.5
Mean time between licks in bursts	3.5	4.9	8.7	0.4	0.3	-2.4	-2.5	2.9	2.9
Mean num. licks in bursts	1.9	2.3	4.0	-1.6	2.0	-1.6	-1.5	1.1	1.1
Cd content in liver	0.2	0.2	0.5	-0.7	0.6	-0.4	-0.4	0.2	0.2
Co content in liver	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1	0.3	0.3
Cu content in liver	0.2	0.2	0.6	-0.4	0.8	-0.5	-0.4	0.3	0.3
Fe content in liver	1.1	1.3	3.0	-1.7	1.5	0.3	0.2	-1.1	-1.1
K content in liver	0.7	0.7	1.0	-0.6	0.4	-1.0	-0.9	1.0	1.0
Mg content in liver	0.3	0.3	0.6	0.3	-0.2	-0.5	-0.4	0.8	0.8
Mn content in liver	0.1	0.1	0.1	-0.3	0.0	-0.4	-0.2	0.3	0.3
Na content in liver	0.0	0.0	0.0	-0.1	0.2	-0.2	-0.0	0.1	0.1
Rb content in liver	1.1	1.4	1.7	-1.3	1.3	-1.3	-1.3	0.9	0.9
Se content in liver	0.4	0.5	1.0	0.6	-1.0	0.7	0.6	-0.5	-0.5
Sr content in liver	1.1	1.0	3.1	1.8	-1.3	0.0	-0.0	0.8	0.8
Zn content in liver	0.4	0.5	0.9	0.6	0.2	-0.5	-0.6	0.9	0.9
Bone: minimum diameter	0.7	1.3	2.9	-1.7	1.3	0.3	0.4	-1.3	-1.3
Time in familiar zone, hab. session 1	1.2	1.1	3.2	-1.8	1.7	-0.3	-0.3	-0.4	-0.4
Time in novel zone, hab. session 1	1.0	1.0	3.4	1.8	-1.4	0.3	0.4	0.4	0.4
Total zone transitions, hab. session 1	0.6	0.9	1.3	0.5	-0.6	1.1	1.1	-1.1	-1.1
Total locomotion distance, hab. session 1	0.1	0.1	0.5	0.7	-0.5	0.2	0.2	0.2	0.2
Locomotion velocity, hab. session 1	0.1	0.2	0.4	0.7	-0.6	0.4	0.4	-0.1	-0.1
Time in familiar zone, hab. session 2	0.6	0.6	1.7	-1.3	1.1	-0.0	0.0	-0.5	-0.5
Time in novel zone, hab. session 2	0.8	0.8	2.5	1.6	-1.3	0.3	0.3	0.2	0.2
Total zone transitions, hab. session 2	0.0	0.0	0.1	-0.2	0.1	-0.3	-0.3	0.2	0.2
Total locomotion distance, hab. session 2	0.2	0.2	0.5	0.7	-0.7	-0.0	-0.0	0.4	0.4
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.3	-0.4	-0.2	-0.2	0.3	0.3
Novel to familiar place preference ratio	0.6	0.6	1.7	1.3	-0.9	0.6	0.8	0.0	0.0
Novelty place preference	0.4	0.4	1.2	1.1	-0.7	0.5	0.6	0.1	0.1
Time in novel zone, NPP test	0.4	0.4	1.3	1.1	-0.7	0.5	0.6	0.1	0.1
Total zone transitions, NPP test	1.0	1.4	1.9	-1.1	1.3	-1.4	-1.3	1.0	1.0
Total locomotion distance, NPP test	0.5	0.7	1.3	0.1	0.1	-0.9	-0.8	1.1	1.1
Locomotion velocity, NPP test	0.6	0.9	1.3	-0.5	0.6	-1.1	-1.1	1.1	1.1
Intraocular pressure	2.9	4.1	5.3	2.2	-2.3	2.2	2.2	-1.5	-1.5
Delta distance traveled before/after self-admin	0.4	0.4	0.7	-0.3	0.9	-0.7	-0.7	0.7	0.7
Delta ambulatory time before/after self-admin	0.7	0.7	1.2	-0.5	1.1	-0.9	-0.9	0.8	0.8
Parametrial fat weight	0.2	0.3	0.6	-0.5	0.8	-0.6	-0.6	0.5	0.5
Pavlov. Cond. lever latency	0.5	0.7	1.2	0.0	0.3	-0.9	-0.8	1.1	1.1
Pavlov. Cond. magazine entry latency	1.8	2.3	3.8	-1.7	2.0	-1.5	-1.7	1.0	1.0
Pavlov. Cond. change in total contacts	1.3	1.4	3.2	-1.4	1.8	-1.0	-1.2	0.6	0.6
Pavlov. Cond. index score	0.2	0.2	0.4	-0.6	0.7	-0.4	-0.6	0.2	0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.3	0.2	0.0	-0.2	-0.2	-0.2
Pavlov. Cond. lever contacts	0.3	0.4	0.7	-0.5	0.2	0.5	0.4	-0.8	-0.8
Pavlov. Cond. magazine entry number	1.6	2.0	2.6	1.2	-1.6	1.5	1.6	-1.2	-1.2
Pavlov. Cond. intertrial magazine entries	1.1	1.3	4.2	2.0	-1.7	0.7	0.8	0.0	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	-0.8	0.8	-0.6	-0.7	0.3	0.3
Pavlov. Cond. response bias	0.7	0.8	2.2	-1.4	1.5	-0.5	-0.7	-0.0	-0.0
Pavlov. Cond. lever latency	0.2	0.2	0.6	0.8	-0.5	0.4	0.3	-0.2	-0.2
Pavlov. Cond. magazine entry latency	1.3	1.5	2.7	-0.6	-0.2	1.2	1.3	-1.6	-1.6
Pavlov. Cond. change in total contacts	0.9	1.3	3.1	-1.8	1.3	-1.0	-1.0	0.6	0.6
Pavlov. Cond. index score	0.3	0.3	1.2	-1.1	0.6	0.0	0.1	-0.4	-0.4
Pavlov. Cond. latency score	0.3	0.4	1.4	-1.2	0.6	0.1	0.2	-0.6	-0.6
Pavlov. Cond. lever contacts	0.2	0.2	0.9	-1.0	0.6	-0.1	-0.1	-0.1	-0.1
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	0.7	-0.3	-0.2	-0.3	0.5	0.5
Pavlov. Cond. intertrial magazine entries	2.2	2.9	3.8	-1.2	1.7	-2.0	-1.9	1.7	1.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	1.2	-1.1	0.6	0.0	0.1	-0.4	-0.4
Pavlov. Cond. response bias	0.1	0.1	0.5	-0.7	0.3	0.1	0.1	-0.2	-0.2
Time in closed arm before self-admin	1.1	1.2	1.5	-1.1	1.2	-1.2	-1.1	1.0	1.0
Time in closed arm after self-admin	0.4	0.4	0.7	0.9	-0.7	-0.3	-0.3	0.7	0.7
Time in open arm before self-admin	0.2	0.2	0.5	0.5	-0.7	0.5	0.4	-0.4	-0.4
Time in open arm after self-admin	0.7	0.7	1.1	0.3	-0.5	1.0	1.0	-1.0	-1.0
Bone: periosteal estimation	0.4	0.9	1.6	-0.2	-0.2	1.0	1.1	-1.3	-1.3
Bone: periosteal perimeter	0.4	0.7	1.1	0.2	-0.3	1.0	1.0	-1.0	-1.0
Bone: post-yield work	0.1	0.1	0.1	0.4	-0.3	0.3	0.3	-0.3	-0.3
Progressive ratio test 1 active lever presses	1.2	1.3	2.3	-1.1	0.6	0.9	0.8	-1.5	-1.5
Progressive ratio test 1 breakpoint	1.1	1.1	2.0	-1.1	0.6	0.8	0.7	-1.4	-1.4
Progressive ratio test 1 inactive lever presses	0.5	0.6	1.0	-1.0	0.7	0.4	0.4	-0.9	-0.9
Progressive ratio test 2 active lever presses	2.5	2.7	4.9	-0.3	-0.2	1.8	1.8	-2.2	-2.2
Progressive ratio test 2 breakpoint	2.7	3.0	5.3	-0.2	-0.2	1.9	1.9	-2.3	-2.3
Progressive ratio test 2 inactive lever presses	0.7	0.9	1.5	-0.6	0.7	0.8	0.8	-1.2	-1.2
Incentive Sensitization - Responses	0.8	0.8	1.5	-0.3	0.1	0.9	0.9	-1.2	-1.2
Incentive Sensitization - Breakpoint	0.8	0.8	1.5	-0.2	0.1	1.0	0.9	-1.2	-1.2
Sum of active levers in priming session hrs 5-6	0.8	0.7	1.3	0.3	-0.2	-0.9	-1.0	1.1	1.1
Progressive ratio	0.2	0.2	0.4	0.2	-0.1	-0.5	-0.5	0.7	0.7
Food seeking constrained by brief footshock	2.3	2.8	5.8	-1.7	2.4	-1.7	-1.7	1.1	1.1
Seeking ratio, punishment vs. effort	1.2	1.4	3.0	-1.2	1.7	-1.2	-1.2	0.8	0.8
Retroperitoneal fat weight	0.3	1.0	1.5	0.4	-0.5	1.2	1.2	-1.2	-1.2
Reaction time number correct	3.9	5.6	15.2	-3.9	3.7	-1.6	-1.5	0.2	0.2
Reaction time mean minus median	0.1	0.2	0.3	-0.3	0.1	-0.5	-0.6	0.4	0.4
Reaction time mean minus median AUC	0.1	0.2	0.2	-0.4	0.3	-0.5	-0.5	0.3	0.3
Reaction time num false alarms	1.0	1.4	1.9	1.0	-1.2	1.4	1.3	-1.0	-1.0
Reaction time num false alarms AUC	1.6	2.2	3.0	1.5	-1.5	1.7	1.7	-1.2	-1.2
Reaction time trials correct on left	3.9	5.6	15.2	-3.9	3.7	-1.6	-1.5	0.2	0.2
Reaction time trials on left	4.1	5.9	15.8	-4.0	3.8	-1.7	-1.6	0.3	0.3
Reaction time mean	0.8	1.1	2.2	1.5	-1.0	-0.5	-0.5	1.2	1.2
Reaction time mean AUC	0.8	1.0	1.7	1.3	-0.7	-0.6	-0.7	1.3	1.3
Median of all reaction times	1.2	1.7	3.7	1.9	-1.3	-0.5	-0.5	1.5	1.5
Reaction time omissions	1.1	1.5	2.6	-1.4	1.6	-1.3	-1.2	0.8	0.8
Reaction time false alarm rate	4.0	5.5	10.7	3.3	-3.3	2.2	2.1	-1.1	-1.1
Reaction time premature initiation rate	0.8	1.1	1.9	-1.4	1.3	-1.0	-1.0	0.6	0.6
Reaction time premature initiations	3.2	4.5	11.0	-3.3	3.2	-1.7	-1.6	0.5	0.5
Std. dev. reaction times	0.0	0.0	0.0	0.2	-0.2	-0.2	-0.2	0.1	0.1
Reaction time trials completed	4.1	5.9	15.8	-4.0	3.8	-1.7	-1.6	0.3	0.3
Reaction time trials AUC	3.6	5.2	14.1	-3.8	3.6	-1.6	-1.4	0.3	0.3
Run reversals in cocaine runway, females	0.1	0.1	0.3	0.6	-0.6	-0.0	-0.0	0.3	0.3
Run reversals in cocaine runway, males	0.6	0.5	0.7	0.5	-0.8	0.8	0.8	-0.7	-0.7
Latency to leave start box in cocaine runway	1.4	1.5	4.0	2.0	-1.4	-0.2	-0.3	1.2	1.2
Latency to leave start box in cocaine runway, F	0.4	0.4	1.3	1.1	-1.0	0.3	0.3	0.2	0.2
Latency to leave start box in cocaine runway, M	1.7	1.6	3.0	1.7	-1.0	-0.7	-0.7	1.6	1.6
Std. dev. time between licks in bursts	0.5	0.5	1.2	0.9	-1.1	-0.2	-0.3	0.8	0.8
Total sessions with >9 infusions	0.9	1.0	1.8	-0.9	0.3	0.9	0.8	-1.4	-1.4
Short access day 1 total inactive lever presses	0.5	0.5	0.8	-0.7	0.8	0.5	0.4	-0.9	-0.9
Short access day 10 total inactive lever presses	0.2	0.3	0.8	0.8	-0.9	0.2	0.3	0.1	0.1
Short access day 1 total infusions	1.0	1.1	2.6	-1.6	1.1	0.3	0.2	-1.1	-1.1
Short access day 10 total infusions	0.6	0.6	1.3	-1.1	1.1	0.2	0.2	-0.8	-0.8
Short access total infusions	1.4	1.5	2.7	-1.7	1.1	0.7	0.6	-1.5	-1.5
Short access day 1 locomotion	0.1	0.1	0.3	-0.5	0.3	-0.2	-0.2	0.0	0.0
Short access day 10 total locomotion	0.0	0.1	0.1	-0.0	-0.0	-0.2	-0.3	0.3	0.3
Short access total locomotion	0.6	0.6	2.0	-1.4	1.0	-0.5	-0.5	-0.0	-0.0
One hour access (0.3 mA shock)	1.0	1.2	1.9	-1.4	0.8	0.6	0.7	-1.4	-1.4
Compulsive drug intake	0.3	0.3	1.1	0.6	-1.0	0.3	0.3	-0.0	-0.0
One hour access (shock baseline)	1.3	1.5	4.0	-2.0	1.9	-0.1	-0.1	-0.8	-0.8
Social response proportion	0.6	0.6	0.9	0.1	-0.7	0.8	0.8	-0.9	-0.9
Social responses	0.3	0.4	1.0	-1.0	0.1	0.3	0.4	-0.7	-0.7
Social time	0.4	0.5	0.7	-0.8	0.6	-0.8	-0.8	0.6	0.6
Soleus weight	0.2	0.7	1.1	0.1	-0.5	0.9	0.8	-1.0	-1.0
Bone: stiffness	0.0	0.0	0.0	0.2	0.0	-0.0	-0.0	-0.0	-0.0
Tibialis anterior weight	2.4	8.1	10.5	2.8	-2.9	3.2	3.1	-2.4	-2.4
Time to tail flick, vehicle, before self-admin	3.3	3.4	4.3	-2.1	2.1	-1.9	-2.0	1.4	1.4
Time to tail flick, vehicle, after self-admin	0.5	0.5	0.8	-0.3	0.6	-0.8	-0.7	0.9	0.9
Time to tail flick, test, before self-admin	0.2	0.2	0.5	-0.7	0.7	-0.3	-0.4	0.2	0.2
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.1	-0.2	0.3	0.3	-0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	3.2	1.8	-1.3	0.5	0.7	0.2	0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.2	-0.3	0.2	0.2	-0.2	-0.2
Tibia length	3.7	10.6	18.1	-3.9	4.3	-3.2	-3.3	2.1	2.1
Ambulatory time before self-admin	1.1	1.2	2.2	-1.0	-0.0	0.9	0.9	-1.5	-1.5
Ambulatory time after self-admin	0.5	0.5	1.7	-1.3	0.9	0.0	-0.0	-0.6	-0.6
Bone: tissue strength	1.0	1.0	2.2	1.5	-1.2	-0.4	-0.3	1.1	1.1
Total heroin consumption	0.3	0.4	0.7	0.6	-0.4	-0.5	-0.5	0.8	0.8
Bone: trabecular number	1.0	1.6	2.5	0.4	-0.3	1.6	1.6	-1.5	-1.5
Bone: trabecular spacing	0.3	0.3	0.5	-0.7	0.6	-0.6	-0.7	0.4	0.4
Bone: trabecular thickness	1.8	2.2	2.8	1.5	-1.5	1.6	1.7	-1.3	-1.3
Bone: trabecular tissue density	1.2	1.7	4.7	2.2	-1.7	-0.3	-0.3	1.1	1.1
Water consumed over 24 hours	2.0	2.4	3.1	1.2	-1.5	1.7	1.7	-1.5	-1.5
Number of responses in last shaping day	1.8	1.8	2.7	0.4	-0.7	1.6	1.6	-1.6	-1.6