LOC120100951

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC120100951	0.32	0.1	0.0e+00	0.2	0.23	0.23	0.21	2.3e-21	3.6e-25	1.4e-25	2.5e-23
2	Adipose	gene expression	LOC120100951	0.42	0.11	0.0e+00	0.29	0.32	0.35	0.1	2.6e-32	1.2e-35	6.8e-40	1.1e-11
3	Adipose	isoform ratio	XR_010064459.1	0.04	0.02	1.5e-03	0.02	0.02	0.01	0.01	5.4e-03	2.2e-03	1.6e-02	1.3e-02
4	Liver	isoform ratio	XR_005501330.2	0.18	0.07	3.6e-13	0.07	0.11	0.09	0.1	9.3e-09	4.0e-12	1.3e-10	8.5e-11
5	Liver	intron excision ratio	chr2_229155005_229158936	0.09	0.04	7.5e-08	0.06	0.06	0.06	0.06	2.5e-07	2.7e-07	4.9e-07	9.0e-08
6	Liver	intron excision ratio	chr2_229155101_229158936	0.34	0.17	0.0e+00	0.17	0.18	0.19	0.18	2.9e-18	5.9e-20	2.2e-20	6.4e-20

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.9	1.7	3.1	-1.3	-1.4	1.8	-0.2	0.7	1.7
Area under the delay curve	0.2	0.4	1.2	-0.3	-0.2	0.1	0.8	0.5	1.1
BMI with tail	2.0	7.0	11.4	3.4	2.8	-2.1	-2.1	-3.0	-2.2
BMI without tail	1.4	7.5	9.9	3.1	2.2	-1.7	-2.9	-3.1	-3.1
Body weight	2.4	10.4	17.4	4.2	3.0	-2.7	-3.1	-3.7	-2.4
Weight adjusted by age	0.0	0.1	0.2	0.1	0.0	-0.3	0.5	-0.0	-0.2
Bone surface	0.6	1.1	4.9	-0.5	-0.2	1.1	-0.3	0.6	2.2
Bone volume	0.4	0.8	2.4	-0.5	-0.6	1.1	-0.7	0.4	1.5
Breakpoint value in progressive ratio session	0.1	0.1	0.4	0.1	-0.2	0.2	-0.2	-0.7	-0.4
Number of licking bursts	0.4	1.1	2.0	1.4	1.1	-1.4	0.8	-0.4	-0.7
Context. condit. distance diff. score	0.3	0.3	1.4	-0.4	-0.1	0.2	1.2	0.5	0.2
Locomotion velocity, session 1	2.1	2.4	3.7	1.6	1.6	-1.9	-0.6	-1.2	-1.9
Locomotion distance, session 1	2.2	2.8	6.4	1.8	2.2	-2.5	0.8	-0.9	-1.0
Locomotion velocity, session 2	0.1	0.1	0.3	0.2	0.5	-0.5	0.4	-0.2	0.4
Locomotion distance, session 2	2.0	2.8	7.5	1.5	2.2	-2.7	1.2	-0.7	-0.8
Locomotion velocity, session 3	1.7	1.9	4.6	1.8	1.8	-2.2	0.1	-0.5	-0.6
Locomotion distance, session 3	0.5	0.5	0.8	0.8	0.9	-0.9	0.8	0.2	-0.6
Stereotopy head waving bouts, day 3	1.0	1.1	3.1	0.9	0.4	-1.1	-1.0	-0.8	-1.8
Stereotopy head waving duration, day 3	1.3	1.6	2.4	1.5	1.1	-1.5	-1.2	-1.1	-1.1
Locomotion velocity, session 7	1.0	1.1	2.1	1.3	1.5	-1.4	0.0	-0.9	-0.4
Locomotion distance, session 7	1.5	1.9	4.8	1.5	2.2	-1.4	1.5	-0.3	0.1
Stereotopy head waving bouts, day 7	0.4	0.4	0.8	-0.4	-0.9	-0.2	-0.9	0.2	-0.9
Stereotopy head waving duration, day 7	0.2	0.3	0.4	-0.2	-0.6	-0.5	-0.6	0.3	-0.7
Locomotion velocity, session 8	0.3	0.3	0.5	0.3	0.7	-0.7	0.7	-0.0	-0.6
Locomotion distance, session 8	1.8	2.6	5.7	1.4	2.2	-2.4	1.6	-0.6	-0.5
Degree of sensitization distance	0.3	0.3	0.9	0.3	0.7	-0.0	0.5	-0.4	0.9
Degree of sensitization stereotypy	0.6	0.7	1.7	-0.8	-1.3	0.4	-1.0	0.3	-0.5
Conditioned locomotion	1.0	1.2	2.3	-1.3	-1.5	1.4	-0.8	0.8	0.0
Cocaine response after cond. corrected	0.3	0.5	1.0	-0.7	-0.8	0.7	-1.0	-0.2	0.4
Cocaine response after cond. not corrected	0.6	0.9	1.6	-1.1	-1.2	1.3	-0.9	-0.1	0.7
Cocaine response before conditioning	0.1	0.1	0.2	0.1	0.5	0.1	0.1	-0.1	0.4
Saline control response	1.0	1.3	3.3	1.2	1.8	-1.7	0.5	0.1	-0.4
Bone: connectivity density	1.8	2.9	6.3	-1.7	-1.3	1.8	1.1	1.5	2.5
Bone: cortical apparent density	0.1	0.2	0.6	0.1	-0.3	-0.2	-0.3	-0.5	-0.8
Bone: cortical area	1.5	2.4	4.8	1.9	1.2	-0.5	-2.2	-1.5	-1.3
Bone: cortical porosity	0.8	0.8	1.1	1.0	1.0	-1.0	-0.7	-0.9	-0.8
Bone: cortical porosity	1.3	1.4	1.9	1.3	1.4	-1.2	-1.1	-1.2	-0.7
Bone: cortical thickness	1.2	2.0	5.5	1.3	0.3	0.0	-2.3	-1.6	-1.5
Bone: cortical thickness	1.4	1.7	5.3	0.5	-0.1	0.3	-2.3	-1.5	-1.5
Bone: cortical tissue density	0.1	0.2	0.6	0.1	-0.2	-0.3	-0.2	-0.5	-0.8
Condit. Reinf. active minus inactive responses	2.4	2.8	5.7	1.9	2.1	-2.4	0.0	-1.3	-1.1
Condit. Reinf. active-inactive response ratio	5.0	5.3	8.3	2.7	2.7	-2.9	-0.9	-2.3	-1.8
Condit. Reinf. active responses	0.8	1.0	2.5	0.8	1.1	-1.6	0.5	-0.5	-0.9
Condit. Reinf. inactive responses	0.9	1.1	1.9	-1.4	-1.3	1.0	0.5	1.2	0.7
Incentive salience index mean	1.4	1.8	3.0	1.5	1.6	-1.7	-0.2	-1.2	-1.1
Condit. Reinf. lever presses	0.1	0.2	0.7	0.3	0.3	-0.3	-0.1	-0.0	-0.9
Condit. Reinf. active minus inactive responses	0.2	0.3	1.4	0.2	-0.3	0.5	-1.2	-0.1	-0.2
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.8	0.1	-0.4	0.5	-0.9	-0.2	-0.7
Condit. Reinf. active responses	0.4	0.5	2.1	0.7	0.3	0.3	-1.4	-0.6	-0.3
Condit. Reinf. inactive responses	0.7	1.1	2.5	1.5	1.6	-0.9	-0.7	-0.8	0.3
Condit. Reinf. lever presses	0.3	0.5	1.4	0.5	0.1	0.5	-1.2	-0.6	-0.6
Condit. Reinf. lever reinforcers received	0.3	0.4	1.9	0.4	0.1	0.5	-1.4	-0.5	-0.3
Conditioned reinforcement - actives	0.3	1.0	1.7	0.4	0.7	-1.3	1.3	1.2	0.8
Conditioned reinforcement - inactives	0.1	0.3	0.7	-0.8	-0.6	0.2	0.6	0.8	-0.2
Conditioned locomotion	1.8	2.7	6.6	-0.9	-0.7	1.0	1.9	2.6	1.9
Patch foraging indifference point 0 sec	0.4	1.1	4.1	-0.6	-0.0	0.2	2.0	1.2	0.8
Patch foraging indifference point AUC	0.1	0.3	1.2	1.1	0.5	-0.1	-0.6	-0.5	0.1
Delay disc. indifference point, 0s delay	1.3	1.4	2.7	-0.6	-0.5	0.7	1.4	1.7	1.7
Delay disc. indifference point, 16s delay	0.3	0.5	0.9	0.8	0.9	-0.7	0.7	-0.1	0.6
Delay disc. indifference point, 2s delay	1.8	2.0	3.4	-1.3	-1.2	1.2	1.0	1.9	1.7
Delay disc. indifference point, 24s delay	0.6	0.9	1.7	-1.3	-1.2	1.0	0.7	0.7	0.6
Delay disc. indifference point, 4s delay	0.2	0.3	0.6	-0.7	-0.6	0.6	0.5	0.2	0.0
Delay disc. indifference point, 8s delay	0.3	0.5	1.3	0.5	0.9	-1.1	0.5	-0.2	0.7
Indifference point function ln k	0.3	1.0	2.2	0.8	1.3	-1.5	0.8	-0.6	-0.6
Indifference point function log k	0.3	1.0	2.2	0.8	1.3	-1.5	0.8	-0.6	-0.6
Patch foraging total patch changes 0 sec	0.3	0.9	3.8	-0.3	0.2	-0.0	1.9	1.0	0.7
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	0.3	0.2	0.1	0.3	-0.1	-0.0
Patch foraging total patch changes 18 sec	0.2	0.4	1.9	0.2	0.1	-0.3	1.4	0.4	0.2
Patch foraging total patch changes 24 sec	0.2	0.6	1.0	0.9	0.9	-1.0	0.6	0.1	-0.8
Patch foraging total patch changes 6 sec	0.1	0.2	0.7	0.1	0.1	0.7	0.8	0.2	-0.3
Patch foraging time to switch 0 sec	0.4	1.4	3.0	-1.7	-1.6	1.1	0.4	1.0	0.3
Patch foraging water rate 0 sec	0.1	0.5	1.4	1.2	1.0	-0.5	-0.4	-0.6	-0.0
Patch foraging water rate 12 sec	0.7	3.0	3.9	2.0	1.8	-1.8	-1.2	-1.7	-1.8
Patch foraging water rate 18 sec	0.4	1.0	1.7	1.2	0.9	-0.5	-0.9	-1.3	-1.0
Patch foraging water rate 24 sec	1.3	1.8	3.4	1.7	1.8	-1.6	0.1	-1.1	-0.9
Patch foraging water rate 6 sec	4.2	6.2	8.8	2.7	2.4	-2.6	-1.6	-3.0	-2.4
Seeking ratio, delayed vs. immediate footshock	2.5	3.5	6.2	-2.5	-2.1	2.2	1.0	1.6	1.4
Distance traveled before self-admin	0.3	0.6	2.3	-0.4	-1.1	0.3	-0.2	0.4	-1.5
Distance traveled after self-admin	0.2	0.4	1.5	-0.1	-0.4	-0.1	0.5	0.3	-1.2
Extensor digitorum longus weight	4.2	16.9	31.9	4.5	2.9	-2.9	-5.7	-4.6	-3.3
Bone: elastic displacement	0.7	0.9	1.4	1.2	0.9	-0.6	-1.2	-1.1	-0.4
Bone: elastic work	1.6	2.1	4.3	1.6	1.0	-0.7	-2.1	-1.9	-0.6
Bone: endosteal estimation	0.2	0.6	1.7	1.1	1.3	-0.7	-0.1	-0.2	0.3
Bone: endosteal perimeter	0.4	0.9	2.1	1.4	1.4	-1.1	-0.4	-0.3	-0.3
Epididymis fat weight	0.7	3.6	6.9	2.6	2.6	-1.9	-0.6	-1.5	-1.3
Delta time in closed arm before/after self-admin	0.7	0.6	2.0	0.8	0.9	-1.4	0.1	-0.3	-0.6
Delta time in open arm before/after self-admin	0.5	0.6	1.1	0.4	1.1	-1.0	0.2	0.5	1.0
Diff in mean of infusions in LGA sessions	0.4	0.7	1.7	-1.1	-1.3	1.0	0.5	-0.2	-0.2
Delay discount exponential model param	0.2	0.3	0.9	0.5	0.4	-0.2	-0.7	-0.4	-1.0
Extinction: sum of active levers before priming	0.5	0.8	1.4	-0.3	-0.7	0.6	-1.1	-1.1	-1.2
Active lever presses in extinction session 6	1.1	1.1	2.9	-0.9	-0.6	0.6	1.7	1.1	0.8
Bone: final force	0.3	0.5	1.0	1.0	0.5	-0.5	-0.6	-0.7	-1.0
Bone: final moment	0.3	0.5	0.9	0.9	0.4	-0.3	-0.8	-0.8	-0.9
Food consumed during 24 hour testing period	0.9	1.8	2.9	1.5	1.3	-1.2	-1.3	-1.7	-0.7
Glucose	1.7	2.7	4.3	1.8	1.6	-1.0	-1.1	-2.1	-1.9
Heart weight	1.2	1.9	3.8	1.9	1.8	-0.9	-1.5	-1.2	0.3
Delay discount hyperbolic model param	0.4	0.5	1.2	0.7	0.5	-0.4	-0.8	-0.6	-1.1
Intermittent access intake day 1-15 change	0.1	0.6	1.2	-1.1	-1.0	0.7	0.5	0.8	-0.0
Intermittent access intake escalation	0.2	1.3	2.1	-1.4	-1.3	1.2	0.9	1.2	0.4
Intermittent access intake escalation 2	0.8	1.4	3.5	-1.5	-1.9	1.4	0.2	0.7	0.2
Intermitt. access day 1 inactive lever presses	0.0	0.4	0.7	0.8	0.8	-0.7	-0.3	-0.8	0.2
Intermitt. access day 15 inactive lever presses	0.2	1.2	1.7	1.2	1.0	-0.8	-1.2	-1.3	-1.0
Intermitt. access escalation Index	0.1	0.2	0.9	-0.1	0.0	0.1	-0.9	-0.3	0.4
Intermittent access day 1 total infusions	0.9	2.6	4.4	1.6	1.5	-1.4	-1.0	-1.8	-2.1
Intermittent access day 15 total infusions	0.3	0.7	3.0	0.3	0.4	-0.2	-0.2	-0.8	-1.7
Intermittent access terminal intake (last 3 days)	0.6	1.0	2.7	0.8	0.8	-1.0	-0.1	-1.1	-1.6
Intermittent access total infusions	1.7	2.0	3.9	1.4	1.3	-1.4	-0.5	-1.5	-2.0
Intermittent access day 1 locomotion	0.8	1.4	2.7	1.6	1.6	-1.1	-0.4	-0.9	-1.0
Intermittent access day 15 total locomotion	0.1	0.4	0.6	-0.2	-0.2	0.5	0.8	0.8	-0.8
Intermittent access total locomotion	0.3	0.4	2.0	0.4	0.1	0.1	-0.2	-0.2	-1.4
Intermittent access standard deviation	0.0	0.1	0.3	0.2	0.0	-0.1	-0.3	-0.3	-0.6
Left kidney weight	0.6	5.1	7.1	2.6	1.7	-1.5	-2.4	-2.7	-2.3
Right kidney weight	0.6	4.4	7.1	2.7	2.1	-1.7	-2.1	-2.4	-1.4
Cocaine induced anxiety	0.1	0.2	0.6	0.3	0.4	-0.1	0.5	0.5	0.8
Post-drug Anxiety	0.4	0.5	1.0	-0.1	-0.1	0.3	0.9	0.9	1.0
Baseline Anxiety	0.1	0.2	0.7	-0.1	-0.2	-0.1	-0.6	-0.6	-0.8
Tail length	0.1	0.6	2.4	0.8	0.0	-0.1	-1.5	-0.6	-0.6
Length with tail	0.5	2.3	4.0	2.0	1.2	-1.1	-1.9	-1.7	-0.7
Length without tail	0.2	1.1	2.3	1.5	1.3	-1.1	-0.3	-0.6	0.9
Times rat made contact with spout	0.4	0.4	0.8	-0.7	-0.9	0.9	-0.5	-0.6	-0.3
Lifetime Intake	1.5	1.8	2.5	1.5	1.6	-1.6	-0.2	-1.3	-1.3
Liver weight, left	0.1	0.2	0.7	0.8	0.2	-0.8	0.3	0.0	-0.1
Liver weight, right	0.1	0.1	0.5	0.5	-0.1	-0.3	0.1	-0.1	-0.7
Locomotor activity	0.2	0.3	0.6	0.4	0.8	-0.1	0.0	-0.5	0.8
Locomotor testing distance	0.2	0.6	1.5	0.7	1.2	-0.5	-0.5	-1.0	0.2
Locomotor testing rearing	0.2	0.8	3.3	0.5	0.6	-0.1	-0.7	-1.8	-0.7
Locomotion in novel chamber	5.5	7.4	12.5	-3.4	-3.2	3.5	1.4	2.3	1.8
Locomotion in novel chamber post-restriction	0.2	0.7	1.9	-1.0	-1.4	0.9	-0.7	-0.1	-0.4
Fecal boli incidents, locomotor time 1	0.0	0.1	0.3	0.1	0.1	-0.5	0.5	0.4	0.1
Change in fecal boli incidents, locomotor task	0.8	0.9	2.6	0.3	0.1	-0.0	-0.7	-1.5	-1.6
Time >=10cm from walls, locomotor time 1	0.4	0.5	1.6	-0.6	-0.7	1.3	0.6	0.4	-0.4
Bouts of movement, locomotor time 1	0.1	0.2	0.4	-0.3	-0.3	0.7	-0.1	-0.3	0.6
Total resting periods, locomotor time 1	0.1	0.1	0.3	0.0	0.1	0.2	0.0	-0.3	0.6
Rest time, locomotor task time 1	0.2	0.3	0.7	-0.3	-0.5	0.2	-0.7	0.2	0.9
Distance moved, locomotor task time 1	0.1	0.3	0.9	0.7	1.0	-0.3	0.1	-0.6	-0.2
Vertical activity count, locomotor time 1	0.0	0.1	0.3	0.1	0.5	0.1	0.5	0.1	0.1
Time >=10cm from walls, locomotor time 2	0.8	2.3	3.2	1.8	1.8	-1.7	-0.7	-1.1	-1.7
Bouts of movement, locomotor time 2	0.3	0.9	1.5	-1.1	-0.8	1.0	0.9	1.2	0.6
Total resting periods, locomotor time 2	0.2	1.0	1.5	-1.2	-0.8	1.1	1.0	1.2	0.5
Rest time, locomotor task time 2	0.6	1.0	2.1	-1.1	-1.4	1.4	-0.4	0.6	0.6
Distance moved, locomotor task time 2	0.4	0.5	1.1	0.6	1.0	-0.9	0.6	0.0	0.7
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.0	0.1	-0.2	0.3	0.2	0.2
Light reinforcement 1	0.9	4.3	8.6	2.6	2.9	-2.2	-0.6	-1.7	-1.4
Light reinforcement 2	0.1	0.2	0.3	0.6	0.4	-0.1	-0.6	-0.5	-0.2
Bone: marrow area	0.2	0.5	1.5	1.0	1.2	-0.6	-0.0	-0.1	0.3
Bone: maximum diameter	0.4	0.8	1.9	1.4	1.3	-0.3	-0.8	-0.4	0.2
Bone: maximum force	0.3	0.6	1.7	1.3	1.1	-0.7	-0.3	-0.4	0.2
Bone: maximum moment	0.3	0.5	1.4	1.2	1.0	-0.5	-0.5	-0.5	0.2
Mean time between licks in bursts	0.0	0.2	0.7	0.4	0.5	-0.4	0.8	0.0	0.0
Mean num. licks in bursts	0.6	1.5	3.2	-1.6	-1.4	1.8	-1.1	-0.1	0.3
Cd content in liver	0.1	0.2	0.4	0.6	0.3	-0.3	-0.2	-0.4	-0.3
Co content in liver	4.9	5.8	9.8	2.9	3.1	-3.1	-0.7	-1.9	-1.6
Cu content in liver	1.1	1.4	2.2	-1.4	-1.3	1.1	1.5	1.1	0.3
Fe content in liver	1.0	1.2	2.8	-1.2	-1.1	1.1	0.5	1.7	0.8
K content in liver	1.6	1.5	3.1	-1.4	-1.8	1.4	0.8	0.9	-0.9
Mg content in liver	0.5	0.5	0.9	-0.6	-0.8	0.3	0.9	0.4	-0.9
Mn content in liver	0.7	0.8	1.1	-0.5	-1.0	0.9	-0.9	-0.7	-1.0
Na content in liver	0.3	0.3	0.5	-0.5	-0.5	0.7	0.3	0.6	0.6
Rb content in liver	0.3	0.3	0.5	-0.0	-0.3	-0.5	0.7	0.6	-0.7
Se content in liver	0.2	0.2	0.4	-0.6	-0.7	0.6	-0.1	0.4	-0.0
Sr content in liver	0.4	0.3	0.8	-0.2	-0.5	0.6	-0.9	-0.6	-0.2
Zn content in liver	13.4	15.7	21.0	-4.6	-4.0	4.3	4.5	3.9	1.9
Bone: minimum diameter	2.8	5.3	8.1	2.8	2.6	-1.9	-2.1	-2.3	-2.0
Time in familiar zone, hab. session 1	0.1	0.2	0.4	0.2	0.3	-0.5	0.5	0.6	-0.0
Time in novel zone, hab. session 1	0.1	0.1	0.3	-0.3	-0.2	0.6	-0.4	-0.1	0.4
Total zone transitions, hab. session 1	2.1	2.9	7.7	2.0	2.2	-2.8	0.4	-0.7	-0.4
Total locomotion distance, hab. session 1	0.5	0.7	1.4	0.7	1.0	-1.2	0.8	0.2	0.5
Locomotion velocity, hab. session 1	0.3	0.5	1.1	0.8	1.0	-1.1	0.5	-0.2	0.1
Time in familiar zone, hab. session 2	1.6	1.8	3.6	-0.6	-1.2	1.5	-1.9	-0.8	-1.5
Time in novel zone, hab. session 2	1.2	1.3	3.5	0.0	0.7	-0.9	1.9	1.0	1.4
Total zone transitions, hab. session 2	1.7	2.2	5.5	1.8	2.0	-2.3	0.6	-0.5	0.2
Total locomotion distance, hab. session 2	0.4	0.5	0.8	0.9	0.9	-0.9	0.1	-0.6	0.3
Locomotion velocity, hab. session 2	0.3	0.3	0.7	0.7	0.7	-0.8	0.3	-0.3	0.5
Novel to familiar place preference ratio	0.1	0.1	0.3	0.2	0.3	-0.3	0.3	-0.3	0.6
Novelty place preference	0.1	0.1	0.3	0.2	0.4	-0.3	0.2	-0.5	0.6
Time in novel zone, NPP test	0.1	0.2	0.3	0.2	0.5	-0.2	0.1	-0.5	0.6
Total zone transitions, NPP test	2.0	3.0	5.5	2.1	2.1	-2.3	-0.2	-1.3	-1.4
Total locomotion distance, NPP test	0.2	0.3	0.5	0.7	0.6	-0.7	0.1	-0.5	-0.4
Locomotion velocity, NPP test	0.2	0.3	0.5	0.7	0.4	-0.6	-0.1	-0.7	-0.7
Intraocular pressure	0.2	0.4	1.4	-0.3	-0.3	0.4	-0.2	0.8	1.2
Delta distance traveled before/after self-admin	0.5	0.6	1.5	0.5	1.2	-0.9	1.0	-0.1	0.1
Delta ambulatory time before/after self-admin	0.2	0.4	1.0	0.4	1.0	-0.6	0.8	-0.2	0.4
Parametrial fat weight	0.1	0.2	0.5	-0.1	-0.5	0.2	0.7	0.5	0.6
Pavlov. Cond. lever latency	0.7	0.9	1.7	0.9	0.5	-0.7	-1.3	-1.3	-0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	0.3	0.5	-0.6	0.3	0.2	-0.1
Pavlov. Cond. change in total contacts	0.5	0.5	2.0	-0.3	0.2	-0.4	1.4	0.8	0.4
Pavlov. Cond. index score	0.3	0.4	0.6	-0.8	-0.5	0.6	0.7	0.8	-0.1
Pavlov. Cond. latency score	0.5	0.6	1.0	-0.9	-0.7	0.7	0.9	1.0	0.2
Pavlov. Cond. lever contacts	0.3	0.4	0.7	-0.6	-0.4	0.6	0.8	0.8	-0.1
Pavlov. Cond. magazine entry number	0.3	0.3	1.0	-0.5	-0.7	1.0	-0.2	0.2	0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.6	-0.2	-0.1	0.2	0.6	0.6	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	-0.9	-0.5	0.6	0.7	0.6	-0.2
Pavlov. Cond. response bias	0.2	0.2	0.4	0.2	0.5	-0.6	0.7	0.5	-0.2
Pavlov. Cond. lever latency	1.1	1.6	3.3	-1.8	-1.8	1.2	0.8	0.9	0.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.4	-0.1	0.2	0.3	0.5	0.5
Pavlov. Cond. change in total contacts	0.1	0.2	0.4	0.6	0.6	-0.2	-0.0	-0.1	0.4
Pavlov. Cond. index score	0.1	0.1	0.3	0.2	0.2	0.2	-0.3	0.3	0.5
Pavlov. Cond. latency score	0.1	0.2	0.6	-0.1	-0.0	0.4	0.2	0.7	0.8
Pavlov. Cond. lever contacts	1.1	1.6	3.2	1.8	1.6	-1.0	-1.2	-1.0	-0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	0.2	0.1	-0.3	-0.1	-0.6	-0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.4	1.5	0.3	-0.1	0.5	-1.2	-0.9	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	0.1	0.1	0.3	-0.2	0.4	0.6
Pavlov. Cond. response bias	1.3	1.8	3.2	1.8	1.7	-1.1	-1.3	-1.0	-0.7
Time in closed arm before self-admin	0.2	0.3	0.8	-0.1	0.2	-0.1	0.9	0.4	0.9
Time in closed arm after self-admin	0.4	0.5	1.7	-0.5	0.0	0.1	1.3	0.5	0.8
Time in open arm before self-admin	1.0	1.2	2.6	0.3	-0.3	0.6	-1.6	-1.5	-1.4
Time in open arm after self-admin	0.2	0.2	0.4	0.5	0.5	-0.4	-0.6	-0.2	0.2
Bone: periosteal estimation	0.8	1.9	3.6	1.9	1.6	-0.8	-1.6	-1.3	-0.8
Bone: periosteal perimeter	1.0	1.9	3.5	1.9	1.6	-1.0	-1.5	-1.1	-0.9
Bone: post-yield work	1.4	2.4	5.5	-0.1	0.6	-0.3	2.2	1.8	2.3
Progressive ratio test 1 active lever presses	2.6	4.5	6.2	2.1	2.2	-2.4	-0.9	-2.2	-2.5
Progressive ratio test 1 breakpoint	2.4	4.2	5.5	2.1	2.2	-2.3	-0.8	-2.2	-2.3
Progressive ratio test 1 inactive lever presses	0.3	0.8	2.4	0.3	0.6	-0.3	-0.8	-1.0	-1.6
Progressive ratio test 2 active lever presses	1.6	2.3	4.0	1.3	0.8	-1.3	-1.5	-1.8	-2.0
Progressive ratio test 2 breakpoint	1.6	2.0	3.7	1.1	0.6	-1.1	-1.5	-1.8	-1.9
Progressive ratio test 2 inactive lever presses	0.1	0.4	1.2	0.4	0.2	-0.7	-0.5	-0.4	-1.1
Incentive Sensitization - Responses	0.2	0.7	2.0	-0.9	-1.4	0.6	0.1	0.8	-0.2
Incentive Sensitization - Breakpoint	0.3	0.7	2.3	-1.0	-1.5	0.8	-0.1	0.7	-0.3
Sum of active levers in priming session hrs 5-6	2.5	2.4	5.6	-1.9	-2.4	2.1	-0.3	-0.1	-0.7
Progressive ratio	0.1	0.4	1.8	-0.1	-0.2	0.6	-1.3	-0.5	-0.2
Food seeking constrained by brief footshock	1.1	1.4	2.1	1.1	1.0	-0.5	-1.4	-1.4	-1.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.5	0.3	0.5	-0.7	0.5	-0.4	-0.4
Retroperitoneal fat weight	0.3	1.6	2.5	1.5	1.1	-0.6	-1.5	-1.6	-0.8
Reaction time number correct	0.1	0.2	0.6	0.2	0.3	-0.1	-0.8	-0.7	0.0
Reaction time mean minus median	0.2	1.5	3.5	-1.5	-1.9	1.3	-0.3	0.9	0.8
Reaction time mean minus median AUC	0.3	1.7	4.3	-1.6	-2.1	1.4	-0.3	0.8	0.8
Reaction time num false alarms	0.7	1.2	2.3	0.6	1.4	-1.2	0.8	0.7	1.5
Reaction time num false alarms AUC	0.5	1.2	2.4	0.9	1.6	-1.4	0.3	0.4	1.2
Reaction time trials correct on left	0.1	0.2	0.6	0.2	0.3	-0.1	-0.8	-0.7	0.0
Reaction time trials on left	0.0	0.2	0.6	0.1	0.1	0.1	-0.7	-0.6	0.1
Reaction time mean	0.5	1.1	2.3	-1.1	-1.5	1.4	-1.2	-0.1	0.1
Reaction time mean AUC	0.4	1.0	1.9	-0.9	-1.3	1.2	-1.4	-0.3	-0.3
Median of all reaction times	0.5	0.8	2.2	-0.5	-1.0	1.0	-1.5	-0.6	-0.4
Reaction time omissions	1.7	2.7	4.2	-2.1	-1.8	1.9	0.2	1.8	1.5
Reaction time false alarm rate	0.6	0.8	1.5	0.4	1.0	-0.9	0.7	0.8	1.2
Reaction time premature initiation rate	1.9	2.9	4.9	2.2	2.0	-1.9	-1.0	-1.1	-1.6
Reaction time premature initiations	1.1	3.2	5.1	2.3	2.0	-1.9	-1.4	-1.5	-1.5
Std. dev. reaction times	0.7	2.4	5.1	-2.0	-2.3	1.8	-0.1	1.2	0.7
Reaction time trials completed	0.0	0.2	0.6	0.1	0.1	0.1	-0.7	-0.6	0.1
Reaction time trials AUC	0.1	0.2	0.6	0.3	0.4	-0.1	-0.8	-0.7	0.2
Run reversals in cocaine runway, females	0.3	0.3	1.0	-0.7	-1.0	0.5	-0.1	-0.4	-0.3
Run reversals in cocaine runway, males	0.4	0.5	1.7	-0.1	0.1	-0.3	-0.8	-1.3	-0.7
Latency to leave start box in cocaine runway	0.2	0.3	1.5	-0.1	0.3	0.1	1.2	0.4	-0.3
Latency to leave start box in cocaine runway, F	0.4	0.5	1.4	0.5	0.9	-0.6	1.2	0.5	-0.1
Latency to leave start box in cocaine runway, M	0.8	0.8	1.9	-1.2	-1.1	1.4	0.4	0.2	-0.0
Std. dev. time between licks in bursts	0.9	1.8	4.8	0.9	1.7	-1.4	2.2	0.3	0.1
Total sessions with >9 infusions	2.0	2.4	5.6	1.6	2.4	-2.2	1.1	-0.5	-0.2
Short access day 1 total inactive lever presses	0.4	0.8	1.8	0.9	1.3	-1.2	0.8	-0.4	-0.5
Short access day 10 total inactive lever presses	0.2	1.5	2.8	-1.0	-0.3	0.6	1.5	1.5	1.7
Short access day 1 total infusions	0.9	1.8	3.7	1.0	1.8	-1.9	1.6	0.4	0.3
Short access day 10 total infusions	0.9	1.5	2.8	1.2	1.7	-1.7	0.3	-1.1	-0.7
Short access total infusions	1.4	1.9	4.2	1.4	2.1	-2.0	0.6	-1.0	-0.4
Short access day 1 locomotion	1.4	2.3	5.2	1.3	2.3	-1.9	1.7	0.4	0.7
Short access day 10 total locomotion	0.0	0.1	0.3	-0.1	0.3	-0.0	0.6	-0.0	0.2
Short access total locomotion	0.5	0.7	1.6	0.5	1.2	-0.6	1.3	0.3	0.5
One hour access (0.3 mA shock)	0.3	0.3	1.4	-0.0	-0.2	0.2	-0.5	-0.5	-1.2
Compulsive drug intake	0.3	0.4	1.0	-0.4	-0.6	1.0	-0.9	-0.3	-0.6
One hour access (shock baseline)	0.2	0.5	1.5	0.3	0.3	-0.6	-0.3	-0.9	-1.2
Social response proportion	0.4	0.6	1.0	-0.8	-0.9	0.6	0.7	1.0	0.3
Social responses	0.1	0.2	0.6	0.0	-0.4	0.8	-0.2	-0.1	-0.5
Social time	1.5	2.3	3.5	-1.6	-1.9	1.9	0.8	1.7	0.9
Soleus weight	1.0	2.8	3.7	1.9	1.4	-1.5	-1.8	-1.6	-1.8
Bone: stiffness	0.5	0.9	2.1	1.4	1.3	-0.8	-0.5	-0.8	-0.3
Tibialis anterior weight	5.4	18.5	38.7	4.6	2.9	-2.6	-6.2	-5.0	-3.3
Time to tail flick, vehicle, before self-admin	0.6	0.7	1.8	-0.5	-0.3	0.1	1.0	1.1	1.3
Time to tail flick, vehicle, after self-admin	0.4	0.8	2.3	-0.4	-0.1	0.5	0.4	1.5	1.5
Time to tail flick, test, before self-admin	1.0	1.2	2.3	-1.0	-0.8	1.1	0.3	1.3	1.5
Time to tail flick, test, after self-admin	0.2	0.2	0.8	0.1	0.1	-0.0	0.5	0.3	0.9
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.4	0.8	1.2	-0.5	0.1	-0.0	-0.3
Delta time to tail flick, test, before/after SA	0.6	0.7	1.1	1.0	0.6	-1.0	-0.1	-0.9	-0.9
Tibia length	0.7	2.1	7.3	1.1	-0.0	-0.0	-2.7	-1.7	-1.1
Ambulatory time before self-admin	0.2	0.7	2.3	-0.5	-1.2	0.3	-0.1	0.4	-1.5
Ambulatory time after self-admin	0.4	0.6	1.6	-0.4	-0.6	-0.1	1.3	1.2	-0.3
Bone: tissue strength	0.5	0.5	1.2	1.1	0.9	-0.6	-0.0	-0.4	0.5
Total heroin consumption	0.4	0.4	1.0	-0.4	-1.0	1.0	-0.5	0.0	0.4
Bone: trabecular number	1.1	2.2	6.2	-1.2	-0.9	1.1	0.8	1.6	2.5
Bone: trabecular spacing	0.5	0.7	2.3	-0.1	-0.3	0.7	-0.6	-0.8	-1.5
Bone: trabecular thickness	0.0	0.0	0.1	0.1	-0.1	-0.3	-0.3	-0.1	0.1
Bone: trabecular tissue density	0.0	0.1	0.2	-0.0	-0.2	-0.4	-0.4	-0.4	-0.1
Water consumed over 24 hours	0.1	0.2	0.5	0.4	-0.0	-0.3	-0.6	-0.7	-0.2
Number of responses in last shaping day	1.9	2.4	5.8	1.7	2.1	-2.4	0.2	-0.6	-0.9