LOC120100778

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	intron excision ratio	chr2_102045520_102050022	0.02	0.02	5.6e-03	0.01	0	0	0	3.3e-02	2.1e-01	6.9e-02	1.2e-01
2	PL	gene expression	LOC120100778	0.04	0.03	4.7e-04	0.01	0.01	0.01	0.01	3.9e-02	9.7e-03	4.1e-02	3.2e-02
3	Brain	gene expression	LOC120100778	0.05	0.04	4.1e-04	0.03	0.02	0.03	0.02	1.9e-03	9.4e-03	1.9e-03	2.5e-03
4	IL	gene expression	LOC120100778	0.23	0.14	1.1e-03	0.06	0.05	0.05	0.04	1.9e-02	2.8e-02	2.1e-02	3.8e-02
5	LHb	mRNA stability	LOC120100778	0.17	0.12	7.8e-03	0.01	0.03	0.04	0.03	1.7e-01	7.1e-02	5.0e-02	8.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.3	2.3	2.6	1.5	-1.3	-1.6	-1.6	1.5
Area under the delay curve	1.2	1.4	1.7	-1.1	0.9	1.3	1.3	-1.3
BMI with tail	3.0	10.2	12.8	-3.4	3.6	3.4	3.4	-1.9
BMI without tail	2.2	6.8	9.1	-2.9	3.0	2.7	2.7	-1.4
Body weight	3.0	13.0	15.1	-3.9	3.7	3.8	3.8	-2.8
Weight adjusted by age	0.4	0.6	0.8	-0.9	0.8	0.8	0.8	-0.5
Bone surface	0.0	0.1	0.2	0.1	0.2	-0.1	-0.1	0.5
Bone volume	0.0	0.1	0.1	0.2	-0.1	-0.3	-0.3	0.3
Breakpoint value in progressive ratio session	0.3	0.3	0.4	-0.6	0.6	0.6	0.6	-0.6
Number of licking bursts	1.7	2.8	3.4	-1.9	1.8	1.7	1.7	-1.3
Context. condit. distance diff. score	0.6	0.7	1.4	-0.8	0.5	0.8	0.8	-1.2
Locomotion velocity, session 1	0.3	0.3	0.7	-0.6	0.8	0.5	0.5	0.0
Locomotion distance, session 1	0.1	0.1	0.1	-0.2	0.2	0.3	0.3	-0.3
Locomotion velocity, session 2	2.7	3.1	3.9	-1.9	2.0	1.9	1.9	-1.1
Locomotion distance, session 2	0.1	0.1	0.2	-0.2	0.4	0.2	0.2	0.3
Locomotion velocity, session 3	0.9	1.0	1.1	-1.0	1.0	1.1	1.1	-0.8
Locomotion distance, session 3	0.6	0.6	0.9	-0.8	1.0	0.8	0.8	-0.3
Stereotopy head waving bouts, day 3	0.1	0.2	0.2	0.4	-0.5	-0.4	-0.4	0.1
Stereotopy head waving duration, day 3	0.3	0.4	0.5	0.7	-0.6	-0.7	-0.7	0.5
Locomotion velocity, session 7	1.8	2.0	2.2	1.5	-1.5	-1.5	-1.5	1.0
Locomotion distance, session 7	2.1	2.6	2.9	1.6	-1.4	-1.7	-1.7	1.6
Stereotopy head waving bouts, day 7	1.4	1.5	3.0	-1.2	0.7	1.2	1.2	-1.7
Stereotopy head waving duration, day 7	0.6	0.8	1.4	-0.9	0.5	0.8	0.8	-1.2
Locomotion velocity, session 8	1.6	2.0	2.2	-1.5	1.2	1.4	1.4	-1.4
Locomotion distance, session 8	1.8	2.6	2.9	-1.7	1.3	1.6	1.6	-1.7
Degree of sensitization distance	4.2	4.3	4.7	2.1	-1.9	-2.2	-2.2	2.0
Degree of sensitization stereotypy	3.9	4.2	6.3	-2.1	1.4	2.0	2.0	-2.5
Conditioned locomotion	1.5	1.7	3.0	1.4	-1.7	-1.4	-1.4	0.4
Cocaine response after cond. corrected	0.2	0.3	0.5	0.5	-0.3	-0.5	-0.5	0.7
Cocaine response after cond. not corrected	0.3	0.3	0.7	0.6	-0.2	-0.5	-0.5	0.8
Cocaine response before conditioning	0.2	0.2	0.5	0.5	-0.2	-0.5	-0.5	0.7
Saline control response	0.4	0.5	0.7	-0.8	0.8	0.7	0.7	-0.4
Bone: connectivity density	1.6	2.6	3.4	1.7	-1.2	-1.6	-1.6	1.8
Bone: cortical apparent density	0.7	0.9	1.1	-1.1	0.9	1.0	1.0	-0.8
Bone: cortical area	0.7	1.1	3.0	-1.0	0.3	0.9	0.9	-1.7
Bone: cortical porosity	0.7	0.8	0.9	0.9	-0.8	-0.9	-0.9	0.9
Bone: cortical porosity	0.2	0.3	0.3	0.5	-0.5	-0.6	-0.6	0.4
Bone: cortical thickness	0.3	0.5	1.3	0.2	-1.0	-0.2	-0.2	-1.1
Bone: cortical thickness	1.0	1.2	1.6	-1.2	1.3	1.2	1.2	-0.6
Bone: cortical tissue density	0.8	1.1	1.3	-1.1	1.1	1.1	1.1	-0.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.3	0.1	0.2	0.2	-0.4
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.1	0.2	-0.0	-0.0	0.2
Condit. Reinf. active responses	0.1	0.1	0.2	-0.4	0.4	0.4	0.4	-0.2
Condit. Reinf. inactive responses	0.3	0.3	0.5	-0.6	0.7	0.6	0.6	-0.2
Incentive salience index mean	0.2	0.2	0.3	-0.5	0.4	0.5	0.5	-0.6
Condit. Reinf. lever presses	0.3	0.4	0.7	-0.6	0.9	0.6	0.6	0.0
Condit. Reinf. active minus inactive responses	0.5	0.7	0.8	-0.9	0.8	0.9	0.9	-0.7
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.6	-0.6	0.8	0.6	0.6	-0.1
Condit. Reinf. active responses	0.2	0.3	0.3	-0.6	0.5	0.6	0.6	-0.5
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.3	0.0	0.3	0.3	-0.6
Condit. Reinf. lever presses	0.4	0.6	0.7	0.8	-0.7	-0.8	-0.8	0.6
Condit. Reinf. lever reinforcers received	0.1	0.2	0.2	-0.5	0.4	0.5	0.5	-0.4
Conditioned reinforcement - actives	0.0	0.0	0.1	0.3	-0.2	-0.0	-0.0	-0.1
Conditioned reinforcement - inactives	0.0	0.0	0.0	0.0	0.1	0.2	0.2	-0.1
Conditioned locomotion	0.5	0.6	0.8	-0.7	0.8	0.9	0.9	-0.7
Patch foraging indifference point 0 sec	0.2	0.4	1.3	-0.2	-0.3	0.5	0.5	-1.2
Patch foraging indifference point AUC	0.6	0.9	1.8	0.8	-0.5	-0.9	-0.9	1.3
Delay disc. indifference point, 0s delay	0.8	0.9	1.9	-0.7	0.4	1.0	1.0	-1.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.0	-0.3	0.0	0.0	-0.5
Delay disc. indifference point, 2s delay	1.5	1.7	3.2	-1.0	0.7	1.3	1.3	-1.8
Delay disc. indifference point, 24s delay	0.3	0.4	0.5	0.7	-0.7	-0.6	-0.6	0.4
Delay disc. indifference point, 4s delay	2.2	2.3	3.0	-1.5	1.5	1.7	1.7	-1.1
Delay disc. indifference point, 8s delay	0.7	0.9	1.0	-0.9	0.9	1.0	1.0	-0.8
Indifference point function ln k	0.8	1.3	2.1	-1.2	1.4	1.2	1.2	-0.4
Indifference point function log k	0.8	1.3	2.1	-1.2	1.4	1.2	1.2	-0.4
Patch foraging total patch changes 0 sec	0.2	0.4	1.3	-0.4	0.0	0.6	0.6	-1.1
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	0.1	-0.3	-0.0	-0.0	-0.2
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	0.4	-0.6	-0.2	-0.2	-0.1
Patch foraging total patch changes 24 sec	0.2	0.4	0.5	0.7	-0.6	-0.6	-0.6	0.5
Patch foraging total patch changes 6 sec	0.2	0.2	0.5	-0.3	0.1	0.5	0.5	-0.7
Patch foraging time to switch 0 sec	0.4	0.8	1.2	-0.9	0.5	1.0	1.0	-1.1
Patch foraging water rate 0 sec	0.1	0.3	0.4	0.6	-0.3	-0.6	-0.6	0.6
Patch foraging water rate 12 sec	1.5	3.2	4.7	1.9	-1.3	-1.8	-1.8	2.2
Patch foraging water rate 18 sec	1.3	2.1	3.1	1.5	-0.9	-1.5	-1.5	1.8
Patch foraging water rate 24 sec	0.8	1.1	3.0	0.8	-0.2	-0.9	-0.9	1.7
Patch foraging water rate 6 sec	0.1	0.2	0.5	0.3	0.1	-0.3	-0.3	0.7
Seeking ratio, delayed vs. immediate footshock	1.6	1.9	2.7	1.5	-1.7	-1.5	-1.5	0.5
Distance traveled before self-admin	4.5	5.9	7.4	-2.7	2.5	2.4	2.4	-2.0
Distance traveled after self-admin	6.2	7.6	8.6	-2.9	2.8	2.9	2.9	-2.3
Extensor digitorum longus weight	6.4	25.0	31.3	-5.3	5.6	5.2	5.2	-3.2
Bone: elastic displacement	3.8	4.4	5.1	2.3	-1.9	-2.1	-2.1	2.0
Bone: elastic work	1.2	1.6	1.8	1.4	-1.2	-1.3	-1.3	1.1
Bone: endosteal estimation	1.4	3.0	4.8	-1.8	2.2	1.8	1.8	-0.8
Bone: endosteal perimeter	2.1	4.5	5.7	-2.2	1.6	2.1	2.1	-2.4
Epididymis fat weight	3.1	10.6	12.1	-3.5	3.3	3.4	3.4	-2.5
Delta time in closed arm before/after self-admin	0.4	0.4	0.7	0.4	-0.4	-0.8	-0.8	0.5
Delta time in open arm before/after self-admin	1.1	1.0	1.5	-0.9	1.0	1.2	1.2	-0.7
Diff in mean of infusions in LGA sessions	0.7	0.9	1.5	1.2	-1.2	-0.8	-0.8	0.5
Delay discount exponential model param	1.1	1.2	1.5	1.0	-0.9	-1.2	-1.2	1.1
Extinction: sum of active levers before priming	1.3	1.4	2.0	-1.3	1.4	1.2	1.2	-0.6
Active lever presses in extinction session 6	0.8	0.8	1.0	-0.9	0.8	1.0	1.0	-0.9
Bone: final force	1.6	2.5	3.0	-1.7	1.6	1.6	1.6	-1.3
Bone: final moment	1.3	2.1	2.6	-1.6	1.5	1.5	1.5	-1.2
Food consumed during 24 hour testing period	3.2	4.4	5.9	-2.2	2.4	2.2	2.2	-1.3
Glucose	0.2	0.4	0.4	-0.7	0.5	0.6	0.6	-0.7
Heart weight	1.2	1.8	2.3	-1.5	1.3	1.4	1.4	-1.1
Delay discount hyperbolic model param	1.4	1.5	1.9	1.1	-1.0	-1.4	-1.4	1.2
Intermittent access intake day 1-15 change	0.0	0.0	0.0	0.2	-0.1	-0.0	-0.0	0.1
Intermittent access intake escalation	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.1	0.1
Intermittent access intake escalation 2	0.2	0.3	0.5	0.7	-0.5	-0.5	-0.5	0.5
Intermitt. access day 1 inactive lever presses	0.1	0.5	0.7	-0.6	0.7	0.8	0.8	-0.6
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.2	0.4	-0.3	-0.3	-0.3	0.2
Intermitt. access escalation Index	0.3	0.4	0.5	0.6	-0.6	-0.7	-0.7	0.5
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.3	0.2
Intermittent access day 15 total infusions	0.8	1.2	1.7	1.3	-1.1	-1.1	-1.1	0.9
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.4	0.7	-0.6	-0.5	-0.5	0.4
Intermittent access total infusions	0.4	0.5	0.7	0.8	-0.8	-0.7	-0.7	0.5
Intermittent access day 1 locomotion	0.5	0.6	0.7	-0.8	0.8	0.8	0.8	-0.6
Intermittent access day 15 total locomotion	0.1	0.2	0.2	-0.3	0.4	0.5	0.5	-0.3
Intermittent access total locomotion	0.2	0.3	0.3	-0.5	0.5	0.6	0.6	-0.4
Intermittent access standard deviation	0.0	0.0	0.1	0.4	-0.2	-0.0	-0.0	0.1
Left kidney weight	0.5	2.3	3.6	-1.6	1.9	1.6	1.6	-0.5
Right kidney weight	1.0	4.4	5.2	-2.3	2.1	2.2	2.2	-1.6
Cocaine induced anxiety	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.5	0.3
Post-drug Anxiety	0.3	0.3	0.4	0.5	-0.6	-0.6	-0.6	0.3
Baseline Anxiety	0.1	0.1	0.2	-0.4	0.4	0.4	0.4	-0.3
Tail length	0.1	0.5	1.0	-0.8	0.4	0.6	0.6	-1.0
Length with tail	1.0	4.3	4.8	-2.2	1.7	2.1	2.1	-2.2
Length without tail	1.2	3.9	4.6	-2.0	1.9	2.1	2.1	-1.7
Times rat made contact with spout	3.7	4.2	5.1	-2.3	1.9	2.0	2.0	-2.0
Lifetime Intake	0.3	0.3	0.5	0.7	-0.6	-0.6	-0.6	0.4
Liver weight, left	1.2	2.0	2.6	-1.6	1.5	1.4	1.4	-1.2
Liver weight, right	5.2	9.1	11.2	-3.3	3.3	3.1	3.1	-2.1
Locomotor activity	1.4	2.1	2.8	-1.5	1.7	1.5	1.5	-0.9
Locomotor testing distance	1.5	2.7	3.1	-1.7	1.8	1.8	1.8	-1.2
Locomotor testing rearing	0.0	0.0	0.0	-0.1	0.0	0.1	0.1	-0.2
Locomotion in novel chamber	0.1	0.1	0.3	-0.2	0.0	0.0	0.0	-0.5
Locomotion in novel chamber post-restriction	0.0	0.1	0.1	0.1	-0.3	-0.2	-0.2	-0.2
Fecal boli incidents, locomotor time 1	0.7	1.0	1.6	-0.9	1.3	1.1	1.1	-0.1
Change in fecal boli incidents, locomotor task	0.5	0.5	0.7	0.8	-0.9	-0.8	-0.8	0.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.3	0.1	-0.1	-0.1	0.6
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.1	0.2	0.2	0.2	0.4
Total resting periods, locomotor time 1	0.1	0.1	0.3	0.1	0.2	0.1	0.1	0.6
Rest time, locomotor task time 1	0.3	0.3	0.7	-0.3	0.8	0.5	0.5	0.6
Distance moved, locomotor task time 1	0.2	0.3	1.2	-0.4	-0.3	0.1	0.1	-1.1
Vertical activity count, locomotor time 1	0.2	0.5	2.2	-0.3	-0.5	0.2	0.2	-1.5
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.1	0.3
Bouts of movement, locomotor time 2	0.3	0.5	1.1	0.8	-1.1	-0.6	-0.6	-0.3
Total resting periods, locomotor time 2	0.2	0.3	0.6	0.6	-0.8	-0.4	-0.4	-0.3
Rest time, locomotor task time 2	0.2	0.2	0.7	0.1	0.5	0.1	0.1	0.9
Distance moved, locomotor task time 2	0.2	0.2	0.6	0.1	-0.8	-0.4	-0.4	-0.4
Vertical activity count, locomotor time 2	0.2	0.2	0.6	-0.5	0.0	0.3	0.3	-0.8
Light reinforcement 1	1.3	3.2	3.9	-2.0	1.8	1.9	1.9	-1.4
Light reinforcement 2	3.9	6.0	9.3	-2.5	1.7	2.4	2.4	-3.0
Bone: marrow area	1.4	3.0	4.9	-1.8	2.2	1.8	1.8	-0.7
Bone: maximum diameter	1.4	2.5	4.1	-1.6	1.1	1.6	1.6	-2.0
Bone: maximum force	1.4	2.4	2.9	-1.7	1.6	1.6	1.6	-1.2
Bone: maximum moment	1.1	1.9	2.3	-1.5	1.5	1.4	1.4	-1.1
Mean time between licks in bursts	0.1	0.3	1.2	-0.1	0.7	-0.1	-0.1	1.1
Mean num. licks in bursts	0.2	0.4	0.6	0.6	-0.8	-0.6	-0.6	0.1
Cd content in liver	0.8	0.9	1.6	-1.0	1.3	1.0	1.0	-0.3
Co content in liver	0.8	0.9	1.2	-1.0	1.1	1.0	1.0	-0.6
Cu content in liver	0.0	0.1	0.1	0.3	-0.3	-0.1	-0.1	0.2
Fe content in liver	0.6	0.7	2.7	-0.2	-0.8	0.1	0.1	-1.6
K content in liver	0.4	0.4	0.9	0.8	-1.0	-0.6	-0.6	0.0
Mg content in liver	0.3	0.3	0.4	0.6	-0.5	-0.5	-0.5	0.6
Mn content in liver	0.0	0.0	0.1	-0.1	0.3	0.1	0.1	0.3
Na content in liver	1.1	1.1	2.6	-1.0	0.4	1.0	1.0	-1.6
Rb content in liver	1.0	1.1	1.8	1.1	-1.4	-1.1	-1.1	0.4
Se content in liver	0.2	0.2	0.8	-0.2	-0.3	0.2	0.2	-0.9
Sr content in liver	1.6	1.4	3.6	1.0	-0.4	-1.0	-1.0	1.9
Zn content in liver	0.1	0.1	0.4	0.4	-0.1	-0.1	-0.1	0.7
Bone: minimum diameter	0.3	0.5	1.1	-0.7	0.3	0.6	0.6	-1.1
Time in familiar zone, hab. session 1	0.0	0.0	0.0	0.2	-0.2	-0.2	-0.2	0.1
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.5	0.5	0.5	0.5	-0.4
Total zone transitions, hab. session 1	0.1	0.2	0.4	-0.4	0.6	0.4	0.4	0.0
Total locomotion distance, hab. session 1	0.2	0.2	0.3	-0.5	0.5	0.5	0.5	-0.3
Locomotion velocity, hab. session 1	0.3	0.4	0.5	-0.6	0.7	0.7	0.7	-0.3
Time in familiar zone, hab. session 2	0.7	0.7	1.1	0.8	-0.6	-0.9	-0.9	1.0
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.3	-0.2	-0.2	-0.2	0.4
Total zone transitions, hab. session 2	0.7	1.0	1.1	-1.0	0.8	1.0	1.0	-0.9
Total locomotion distance, hab. session 2	0.1	0.2	0.2	-0.4	0.4	0.4	0.4	-0.4
Locomotion velocity, hab. session 2	0.2	0.3	0.4	-0.6	0.4	0.6	0.6	-0.6
Novel to familiar place preference ratio	1.8	1.9	2.6	1.5	-1.6	-1.5	-1.5	0.7
Novelty place preference	1.6	1.7	2.1	1.4	-1.5	-1.4	-1.4	0.8
Time in novel zone, NPP test	1.2	1.3	2.0	1.2	-1.4	-1.2	-1.2	0.5
Total zone transitions, NPP test	0.1	0.1	0.2	-0.4	0.4	0.4	0.4	-0.2
Total locomotion distance, NPP test	0.2	0.2	0.3	-0.5	0.4	0.5	0.5	-0.3
Locomotion velocity, NPP test	0.0	0.0	0.1	0.1	0.1	-0.0	-0.0	0.3
Intraocular pressure	2.1	3.0	4.8	-1.8	2.2	1.8	1.8	-0.5
Delta distance traveled before/after self-admin	0.2	0.2	0.4	0.6	-0.4	-0.4	-0.4	0.4
Delta ambulatory time before/after self-admin	0.9	1.1	1.5	1.2	-1.0	-1.0	-1.0	1.0
Parametrial fat weight	1.7	4.0	4.9	-2.2	1.9	2.0	2.0	-1.7
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.3	-0.5	-0.3	-0.3	-0.1
Pavlov. Cond. magazine entry latency	0.3	0.4	1.1	-0.2	0.9	0.1	0.1	1.0
Pavlov. Cond. change in total contacts	1.4	1.5	1.9	-1.3	1.4	1.2	1.2	-0.8
Pavlov. Cond. index score	0.7	0.9	2.1	-0.9	1.5	0.9	0.9	0.2
Pavlov. Cond. latency score	0.5	0.6	1.4	-0.8	1.2	0.7	0.7	0.2
Pavlov. Cond. lever contacts	0.2	0.3	0.7	-0.4	0.8	0.4	0.4	0.4
Pavlov. Cond. magazine entry number	0.7	0.9	2.2	0.8	-1.5	-0.8	-0.8	-0.5
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.8	0.7	-0.9	-0.6	-0.6	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	2.4	-1.1	1.6	1.0	1.0	-0.0
Pavlov. Cond. response bias	0.7	0.8	2.0	-0.8	1.4	0.8	0.8	0.4
Pavlov. Cond. lever latency	0.2	0.3	0.8	-0.3	0.9	0.3	0.3	0.8
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	-0.2	0.7	0.2	0.2	0.6
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.1	-0.5	-0.1	-0.1	-0.5
Pavlov. Cond. index score	0.0	0.0	0.1	-0.2	0.0	0.1	0.1	-0.3
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.1	0.0	0.0	0.0	-0.2
Pavlov. Cond. lever contacts	0.3	0.4	0.9	0.3	-0.9	-0.3	-0.3	-0.8
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.1	-0.1
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.8	0.5	-0.1	-0.4	-0.4	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.1	-0.3	0.2	0.2	0.2	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.5	-0.0	-0.4	-0.0	-0.0	-0.7
Time in closed arm before self-admin	0.6	0.8	1.0	1.0	-0.9	-0.9	-0.9	0.7
Time in closed arm after self-admin	0.8	0.8	1.1	0.9	-0.8	-1.1	-1.1	0.7
Time in open arm before self-admin	0.0	0.0	0.1	0.2	-0.2	-0.0	-0.0	-0.1
Time in open arm after self-admin	4.1	4.4	5.7	-2.1	2.1	2.4	2.4	-1.5
Bone: periosteal estimation	1.2	2.6	2.9	-1.7	1.5	1.7	1.7	-1.5
Bone: periosteal perimeter	1.9	3.3	6.1	-1.8	1.0	1.7	1.7	-2.5
Bone: post-yield work	1.1	1.6	3.1	-1.3	1.8	1.3	1.3	-0.3
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	-0.5	0.5	0.5	0.5	-0.3
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	-0.5	0.6	0.5	0.5	-0.4
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.4	0.6	-0.5	-0.5	-0.5	0.4
Progressive ratio test 2 active lever presses	0.2	0.2	0.3	0.6	-0.5	-0.5	-0.5	0.3
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	0.6	-0.6	-0.5	-0.5	0.3
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	-0.0	0.0	0.1	0.1	-0.1
Incentive Sensitization - Responses	0.6	0.8	1.0	1.0	-1.0	-0.9	-0.9	0.6
Incentive Sensitization - Breakpoint	0.6	0.8	1.0	1.0	-1.0	-0.9	-0.9	0.6
Sum of active levers in priming session hrs 5-6	1.1	1.0	1.6	-1.1	1.3	1.0	1.0	-0.5
Progressive ratio	0.4	0.6	0.9	0.7	-0.7	-0.9	-0.9	0.5
Food seeking constrained by brief footshock	1.4	1.7	2.1	1.1	-1.0	-1.5	-1.5	1.4
Seeking ratio, punishment vs. effort	0.0	0.1	0.3	0.0	0.2	0.1	0.1	0.5
Retroperitoneal fat weight	0.9	4.0	5.7	-2.2	2.4	2.1	2.1	-0.8
Reaction time number correct	0.8	1.5	1.9	1.2	-1.1	-1.4	-1.4	1.1
Reaction time mean minus median	2.4	6.1	10.9	-2.5	3.3	2.6	2.6	-0.4
Reaction time mean minus median AUC	2.2	5.6	10.9	-2.4	3.3	2.4	2.4	-0.0
Reaction time num false alarms	1.2	1.7	2.1	1.3	-1.3	-1.4	-1.4	0.9
Reaction time num false alarms AUC	0.7	1.0	1.3	1.0	-1.0	-1.2	-1.2	0.8
Reaction time trials correct on left	0.8	1.5	1.9	1.2	-1.1	-1.4	-1.4	1.1
Reaction time trials on left	0.7	1.4	1.7	1.1	-1.0	-1.3	-1.3	1.0
Reaction time mean	1.4	2.2	4.4	-1.3	2.1	1.5	1.5	0.2
Reaction time mean AUC	1.3	2.0	4.2	-1.2	2.1	1.5	1.5	0.3
Median of all reaction times	0.5	0.7	1.6	-0.6	1.3	0.8	0.8	0.5
Reaction time omissions	1.5	2.2	3.9	-1.5	2.0	1.6	1.6	-0.2
Reaction time false alarm rate	0.1	0.1	0.2	0.3	-0.4	-0.3	-0.3	-0.1
Reaction time premature initiation rate	0.6	0.9	2.1	0.7	-0.3	-0.9	-0.9	1.5
Reaction time premature initiations	0.8	1.5	3.3	1.0	-0.5	-1.2	-1.2	1.8
Std. dev. reaction times	2.6	4.8	8.4	-2.2	2.9	2.3	2.3	-0.4
Reaction time trials completed	0.7	1.4	1.7	1.1	-1.0	-1.3	-1.3	1.0
Reaction time trials AUC	0.5	1.0	1.3	1.0	-0.9	-1.1	-1.1	0.8
Run reversals in cocaine runway, females	0.5	0.5	1.0	-0.5	0.4	0.7	0.7	-1.0
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.1	-0.4	-0.1	-0.1	-0.5
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.1	0.3
Latency to leave start box in cocaine runway, F	0.1	0.2	0.5	0.1	-0.1	-0.4	-0.4	0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.4	0.3	0.3	0.3	-0.3
Std. dev. time between licks in bursts	0.8	1.1	2.1	0.9	-0.5	-1.0	-1.0	1.4
Total sessions with >9 infusions	0.1	0.2	0.2	-0.4	0.4	0.5	0.5	-0.4
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.4	0.3	0.4	0.4	-0.4
Short access day 10 total inactive lever presses	0.4	1.0	1.4	1.1	-1.2	-1.0	-1.0	0.6
Short access day 1 total infusions	1.0	1.3	1.6	-1.2	1.1	1.3	1.3	-1.0
Short access day 10 total infusions	0.3	0.4	0.5	0.7	-0.7	-0.6	-0.6	0.3
Short access total infusions	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.1	-0.1
Short access day 1 locomotion	1.2	1.5	1.7	-1.1	1.1	1.3	1.3	-1.1
Short access day 10 total locomotion	0.1	0.3	0.4	-0.4	0.4	0.6	0.6	-0.5
Short access total locomotion	1.3	1.5	1.8	-1.2	1.1	1.4	1.4	-1.1
One hour access (0.3 mA shock)	0.2	0.2	0.4	0.6	-0.5	-0.4	-0.4	0.2
Compulsive drug intake	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	-0.2
One hour access (shock baseline)	1.2	1.8	2.5	1.6	-1.4	-1.3	-1.3	1.1
Social response proportion	0.2	0.2	0.6	-0.4	0.7	0.4	0.4	0.3
Social responses	1.3	1.7	2.0	-1.4	1.4	1.3	1.3	-0.8
Social time	0.2	0.3	0.8	0.6	-0.3	-0.5	-0.5	0.9
Soleus weight	0.4	1.1	1.4	-1.2	1.0	1.0	1.0	-1.0
Bone: stiffness	2.5	4.0	5.0	-2.2	1.9	2.0	2.0	-1.8
Tibialis anterior weight	6.7	22.8	26.5	-5.1	5.1	4.9	4.9	-3.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.3	0.0	0.3	0.3	-0.5
Time to tail flick, vehicle, after self-admin	1.7	2.3	3.0	1.7	-1.7	-1.5	-1.5	1.0
Time to tail flick, test, before self-admin	0.2	0.2	0.2	-0.2	0.3	0.5	0.5	-0.4
Time to tail flick, test, after self-admin	4.2	4.3	5.2	2.2	-2.3	-2.2	-2.2	1.4
Delta time to tail flick, vehicle, before/after SA	4.3	4.1	5.3	2.3	-2.2	-2.0	-2.0	1.6
Delta time to tail flick, test, before/after SA	1.5	1.5	1.7	1.2	-1.3	-1.3	-1.3	1.0
Tibia length	0.2	0.6	0.8	-0.8	0.6	0.8	0.8	-0.9
Ambulatory time before self-admin	5.0	7.5	9.4	-3.1	2.8	2.7	2.7	-2.2
Ambulatory time after self-admin	2.1	2.4	2.8	-1.7	1.6	1.6	1.6	-1.3
Bone: tissue strength	0.0	0.0	0.1	0.2	-0.3	-0.2	-0.2	-0.2
Total heroin consumption	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	0.0
Bone: trabecular number	1.1	1.8	2.1	1.4	-1.2	-1.4	-1.4	1.3
Bone: trabecular spacing	0.1	0.1	0.2	-0.3	0.1	0.4	0.4	-0.5
Bone: trabecular thickness	1.1	1.4	2.0	1.1	-0.8	-1.3	-1.3	1.4
Bone: trabecular tissue density	2.3	3.4	6.3	-1.8	1.0	1.8	1.8	-2.5
Water consumed over 24 hours	0.5	0.7	0.9	-0.9	0.9	0.8	0.8	-0.6
Number of responses in last shaping day	0.8	0.8	1.0	-0.9	1.0	1.0	1.0	-0.6