LOC120100694

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	LOC120100694	0.41	0.2	1.2e-06	0.18	0.17	0.19	0.22	5.1e-05	7.5e-05	2.2e-05	6.0e-06
2	Brain	intron excision ratio	chr2_35128351_35131244	0.08	0.07	2.5e-07	0.07	0.08	0.08	0.07	3.3e-07	1.1e-07	1.1e-07	2.2e-07
3	PL	gene expression	LOC120100694	0.2	0.08	0.0e+00	0.2	0.09	0.2	0.07	3.8e-21	8.6e-10	2.2e-21	2.3e-08
4	BLA	gene expression	LOC120100694	0.22	0.07	1.7e-16	0.3	0.1	0.31	0.16	1.5e-16	3.0e-06	6.9e-17	9.4e-09
5	NAcc	gene expression	LOC120100694	0.12	0.04	0.0e+00	0.27	0.27	0.27	0.27	4.3e-31	2.3e-31	1.6e-31	9.9e-32
6	Brain	gene expression	LOC120100694	0.12	0.1	1.2e-11	0.12	0.13	0.11	0.12	6.2e-11	9.0e-12	9.3e-11	3.7e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.7	1.1	1.3	1.1	-1.1	-1.0	-1.1	1.0	1.1
Area under the delay curve	0.5	0.5	0.8	-0.6	0.1	0.8	0.9	-0.8	-0.6
BMI with tail	1.8	5.9	7.4	2.5	-2.7	-2.3	-2.3	2.2	2.4
BMI without tail	0.3	0.6	1.1	0.7	-1.1	-0.7	-0.7	0.6	0.8
Body weight	1.7	7.3	7.8	-2.7	2.5	2.8	2.7	-2.8	-2.7
Weight adjusted by age	0.2	0.2	0.3	-0.5	0.4	0.4	0.3	-0.4	-0.4
Bone surface	0.0	0.1	0.2	0.4	-0.4	-0.1	-0.2	0.1	0.3
Bone volume	0.1	0.2	0.3	0.6	-0.6	-0.4	-0.5	0.4	0.5
Breakpoint value in progressive ratio session	3.1	3.4	4.6	1.9	-2.1	-1.7	-1.7	1.7	1.8
Number of licking bursts	3.5	4.1	4.5	2.1	-2.1	-2.0	-2.0	2.0	2.0
Context. condit. distance diff. score	1.6	1.9	2.2	-1.3	1.1	1.5	1.5	-1.5	-1.4
Locomotion velocity, session 1	0.4	0.4	0.4	-0.7	0.7	0.6	0.6	-0.6	-0.6
Locomotion distance, session 1	0.7	0.9	1.0	-1.0	0.8	1.0	1.0	-1.0	-0.9
Locomotion velocity, session 2	4.3	5.0	5.5	-2.3	2.4	2.2	2.2	-2.2	-2.2
Locomotion distance, session 2	0.6	0.8	1.0	-0.9	0.6	1.0	1.0	-1.0	-0.9
Locomotion velocity, session 3	4.6	5.3	5.5	-2.3	2.2	2.3	2.3	-2.3	-2.3
Locomotion distance, session 3	7.3	7.9	8.4	-2.8	2.6	2.9	2.9	-2.9	-2.8
Stereotopy head waving bouts, day 3	0.3	0.3	0.6	-0.6	0.8	0.4	0.4	-0.4	-0.6
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.0	0.1	-0.3	-0.3	0.3	0.1
Locomotion velocity, session 7	0.1	0.1	0.2	-0.3	0.4	0.3	0.3	-0.3	-0.3
Locomotion distance, session 7	0.4	0.5	0.6	-0.7	0.6	0.8	0.8	-0.8	-0.7
Stereotopy head waving bouts, day 7	0.1	0.1	0.1	0.1	0.1	-0.3	-0.4	0.3	0.2
Stereotopy head waving duration, day 7	0.1	0.1	0.2	-0.4	0.5	0.1	0.1	-0.1	-0.3
Locomotion velocity, session 8	2.6	3.1	3.4	-1.8	1.8	1.7	1.6	-1.7	-1.7
Locomotion distance, session 8	3.9	5.7	6.4	-2.4	2.0	2.5	2.5	-2.5	-2.4
Degree of sensitization distance	3.1	3.1	3.4	1.7	-1.5	-1.9	-1.8	1.9	1.7
Degree of sensitization stereotypy	0.0	0.0	0.1	0.1	-0.1	-0.3	-0.3	0.3	0.2
Conditioned locomotion	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.2	0.2	0.3
Cocaine response after cond. corrected	1.6	1.8	1.8	-1.4	1.3	1.3	1.3	-1.3	-1.3
Cocaine response after cond. not corrected	2.1	2.3	2.6	-1.5	1.4	1.6	1.6	-1.6	-1.5
Cocaine response before conditioning	0.3	0.4	0.5	-0.6	0.5	0.7	0.7	-0.7	-0.6
Saline control response	1.0	1.3	1.5	-1.2	1.1	1.1	1.2	-1.1	-1.1
Bone: connectivity density	0.1	0.1	0.2	0.3	-0.4	-0.3	-0.3	0.3	0.3
Bone: cortical apparent density	0.2	0.2	0.4	-0.5	0.6	0.4	0.4	-0.4	-0.4
Bone: cortical area	0.1	0.2	0.4	-0.5	0.6	0.4	0.3	-0.3	-0.4
Bone: cortical porosity	1.5	1.6	2.1	1.2	-0.8	-1.4	-1.4	1.5	1.2
Bone: cortical porosity	1.5	1.7	2.1	1.2	-0.9	-1.4	-1.4	1.4	1.3
Bone: cortical thickness	0.2	0.3	0.7	-0.6	0.9	0.4	0.3	-0.4	-0.5
Bone: cortical thickness	0.9	1.1	1.2	-1.1	1.0	1.1	1.1	-1.1	-1.0
Bone: cortical tissue density	0.2	0.2	0.4	-0.5	0.7	0.4	0.4	-0.4	-0.5
Condit. Reinf. active minus inactive responses	1.5	1.7	2.1	1.2	-0.9	-1.4	-1.4	1.4	1.3
Condit. Reinf. active-inactive response ratio	1.6	1.8	2.1	1.3	-1.0	-1.4	-1.4	1.5	1.3
Condit. Reinf. active responses	0.2	0.2	0.3	0.4	-0.3	-0.6	-0.6	0.6	0.5
Condit. Reinf. inactive responses	1.2	1.4	1.5	-1.2	1.0	1.2	1.2	-1.2	-1.2
Incentive salience index mean	1.1	1.3	1.5	1.1	-0.9	-1.2	-1.2	1.2	1.1
Condit. Reinf. lever presses	0.4	0.5	0.6	0.8	-0.8	-0.7	-0.7	0.7	0.7
Condit. Reinf. active minus inactive responses	3.6	4.5	4.6	-2.1	2.1	2.2	2.1	-2.1	-2.1
Condit. Reinf. active-inactive response ratio	2.2	2.3	3.1	-1.6	1.8	1.5	1.4	-1.4	-1.5
Condit. Reinf. active responses	1.2	1.6	1.7	-1.3	1.3	1.3	1.2	-1.3	-1.3
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.2	0.2	0.3	0.3	-0.3	-0.3
Condit. Reinf. lever presses	1.7	2.2	2.4	-1.5	1.5	1.5	1.5	-1.5	-1.5
Condit. Reinf. lever reinforcers received	1.6	2.3	2.4	-1.5	1.6	1.5	1.5	-1.5	-1.5
Conditioned reinforcement - actives	2.7	2.7	2.9	-1.7	1.6	1.6	1.7	-1.6	-1.7
Conditioned reinforcement - inactives	0.3	0.3	0.6	-0.7	0.7	0.4	0.5	-0.4	-0.6
Conditioned locomotion	0.7	0.8	0.9	-0.9	0.9	0.9	0.9	-0.9	-0.9
Patch foraging indifference point 0 sec	4.5	7.2	8.4	-2.9	2.8	2.5	2.7	-2.5	-2.7
Patch foraging indifference point AUC	1.1	1.2	1.8	1.1	-1.3	-1.0	-1.0	1.0	1.1
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	0.3	-0.4	-0.5	-0.4	0.5	0.4
Delay disc. indifference point, 16s delay	0.9	0.9	1.3	-0.8	0.4	1.1	1.1	-1.2	-0.9
Delay disc. indifference point, 2s delay	0.0	0.1	0.1	0.1	0.2	-0.3	-0.2	0.3	0.1
Delay disc. indifference point, 24s delay	0.7	0.7	1.2	-0.6	0.0	1.1	1.0	-1.1	-0.7
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.2	0.0	0.1	0.3	-0.1	-0.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.2	-0.5	0.4	0.4	-0.4	-0.2
Indifference point function ln k	4.6	6.4	7.3	-2.6	2.7	2.4	2.5	-2.4	-2.5
Indifference point function log k	4.6	6.4	7.3	-2.6	2.7	2.4	2.5	-2.4	-2.5
Patch foraging total patch changes 0 sec	5.5	8.9	10.2	-3.2	3.2	2.8	2.9	-2.7	-3.0
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	0.1	-0.2	-0.0	0.0	0.0	0.0
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	-0.1	0.0	-0.0	0.1	0.1	-0.1
Patch foraging total patch changes 24 sec	0.7	0.8	1.0	-1.0	0.9	0.9	0.9	-0.8	-1.0
Patch foraging total patch changes 6 sec	0.9	1.3	1.5	-1.2	1.2	1.0	1.2	-1.0	-1.2
Patch foraging time to switch 0 sec	6.2	9.5	10.6	3.2	-3.2	-3.0	-3.0	3.0	3.1
Patch foraging water rate 0 sec	5.5	8.9	9.8	-3.1	3.1	2.9	2.9	-2.9	-3.0
Patch foraging water rate 12 sec	5.3	8.1	9.6	-3.0	3.1	2.7	2.7	-2.7	-2.8
Patch foraging water rate 18 sec	6.6	8.9	9.4	-3.0	3.1	3.0	2.9	-3.0	-2.9
Patch foraging water rate 24 sec	3.1	4.3	5.9	-2.2	2.4	1.9	1.9	-2.0	-2.0
Patch foraging water rate 6 sec	14.3	20.9	22.7	-4.8	4.7	4.5	4.4	-4.5	-4.5
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	1.6	1.3	-1.2	-1.2	-1.2	1.2	1.2
Distance traveled before self-admin	2.1	2.3	2.6	-1.4	1.4	1.6	1.6	-1.6	-1.5
Distance traveled after self-admin	1.5	1.6	1.8	-1.3	1.2	1.3	1.2	-1.3	-1.3
Extensor digitorum longus weight	4.0	15.7	16.6	4.0	-3.7	-4.1	-4.1	4.0	4.0
Bone: elastic displacement	1.4	1.6	1.8	1.3	-1.3	-1.2	-1.3	1.2	1.3
Bone: elastic work	0.7	0.9	1.1	1.0	-1.1	-0.9	-0.9	0.9	0.9
Bone: endosteal estimation	0.2	0.4	0.6	-0.6	0.4	0.7	0.8	-0.7	-0.6
Bone: endosteal perimeter	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.1	0.2	0.2
Epididymis fat weight	0.0	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1
Delta time in closed arm before/after self-admin	4.4	4.2	6.5	2.2	-2.5	-1.8	-1.9	1.8	2.0
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.0	-0.1	-0.2	-0.1	0.2	0.1
Diff in mean of infusions in LGA sessions	0.3	0.3	0.5	0.4	-0.5	-0.6	-0.7	0.6	0.6
Delay discount exponential model param	0.5	0.5	0.8	0.6	-0.1	-0.8	-0.9	0.8	0.7
Extinction: sum of active levers before priming	1.8	1.8	2.6	1.3	-1.6	-1.3	-1.3	1.2	1.3
Active lever presses in extinction session 6	2.4	2.3	2.6	1.6	-1.6	-1.5	-1.5	1.4	1.5
Bone: final force	0.7	1.1	1.2	-1.0	0.9	1.1	1.1	-1.1	-1.0
Bone: final moment	0.9	1.4	1.5	-1.2	1.1	1.2	1.2	-1.2	-1.2
Food consumed during 24 hour testing period	1.0	1.2	1.7	-1.1	1.3	1.0	1.0	-1.0	-1.1
Glucose	0.8	1.2	1.7	1.0	-0.5	-1.3	-1.2	1.3	1.0
Heart weight	0.4	0.6	0.7	0.8	-0.6	-0.8	-0.7	0.8	0.7
Delay discount hyperbolic model param	0.3	0.4	0.6	0.6	-0.2	-0.7	-0.8	0.7	0.6
Intermittent access intake day 1-15 change	0.1	0.1	0.3	-0.4	0.5	0.1	0.1	-0.1	-0.2
Intermittent access intake escalation	0.2	0.2	0.5	-0.6	0.7	0.2	0.2	-0.2	-0.4
Intermittent access intake escalation 2	0.0	0.0	0.0	-0.0	0.1	-0.1	-0.2	0.1	0.1
Intermitt. access day 1 inactive lever presses	2.7	2.9	3.3	1.8	-1.6	-1.7	-1.7	1.7	1.7
Intermitt. access day 15 inactive lever presses	3.1	3.4	4.0	2.0	-1.9	-1.8	-1.8	1.8	1.8
Intermitt. access escalation Index	0.2	0.2	0.3	-0.2	0.3	0.5	0.4	-0.5	-0.3
Intermittent access day 1 total infusions	0.8	0.9	1.1	-0.8	1.0	1.0	1.0	-1.0	-1.0
Intermittent access day 15 total infusions	1.7	1.9	2.8	-1.5	1.7	1.2	1.3	-1.2	-1.4
Intermittent access terminal intake (last 3 days)	0.8	0.9	1.1	-0.9	1.0	0.9	0.9	-0.8	-0.9
Intermittent access total infusions	2.0	2.3	2.7	-1.5	1.7	1.4	1.5	-1.4	-1.5
Intermittent access day 1 locomotion	2.5	2.6	3.1	-1.6	1.8	1.5	1.6	-1.5	-1.6
Intermittent access day 15 total locomotion	2.1	2.3	3.7	-1.6	1.9	1.3	1.3	-1.3	-1.5
Intermittent access total locomotion	5.0	5.7	7.3	-2.4	2.7	2.2	2.3	-2.2	-2.4
Intermittent access standard deviation	0.5	0.6	0.7	0.7	-0.7	-0.8	-0.7	0.8	0.7
Left kidney weight	1.0	2.8	3.2	-1.8	1.8	1.6	1.6	-1.6	-1.7
Right kidney weight	0.3	0.7	0.8	-0.9	0.8	0.8	0.9	-0.8	-0.9
Cocaine induced anxiety	0.9	1.0	1.4	-0.9	0.6	1.2	1.1	-1.2	-1.0
Post-drug Anxiety	1.3	1.4	1.8	-1.0	0.9	1.3	1.3	-1.3	-1.2
Baseline Anxiety	0.0	0.0	0.0	-0.0	0.2	0.1	0.0	-0.0	-0.1
Tail length	8.4	25.4	27.5	-5.2	5.2	5.0	4.9	-4.9	-5.0
Length with tail	12.2	44.8	46.9	-6.8	6.8	6.6	6.6	-6.6	-6.7
Length without tail	7.3	15.9	16.9	-4.0	4.1	4.0	4.0	-3.9	-4.0
Times rat made contact with spout	0.3	0.4	0.5	0.7	-0.5	-0.6	-0.6	0.6	0.7
Lifetime Intake	1.8	2.1	2.4	-1.4	1.5	1.4	1.5	-1.4	-1.5
Liver weight, left	0.5	0.9	2.8	-1.1	1.7	0.5	0.5	-0.4	-0.8
Liver weight, right	0.1	0.1	0.1	0.3	-0.2	-0.4	-0.4	0.4	0.3
Locomotor activity	0.3	0.5	0.6	-0.6	0.3	0.8	0.8	-0.8	-0.6
Locomotor testing distance	0.4	0.7	1.3	0.7	-1.2	-0.7	-0.7	0.7	0.8
Locomotor testing rearing	0.3	0.4	0.6	0.6	-0.8	-0.6	-0.6	0.6	0.7
Locomotion in novel chamber	1.1	1.4	2.1	1.3	-1.4	-1.0	-1.1	1.0	1.1
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	0.4	-0.5	-0.1	-0.1	0.1	0.3
Fecal boli incidents, locomotor time 1	2.4	2.6	3.4	1.7	-1.8	-1.5	-1.5	1.5	1.7
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.2	0.1	-0.0	-0.0	-0.0	-0.1
Time >=10cm from walls, locomotor time 1	1.8	1.8	2.1	1.3	-1.1	-1.4	-1.4	1.5	1.3
Bouts of movement, locomotor time 1	0.4	0.5	0.7	0.6	-0.8	-0.6	-0.6	0.6	0.7
Total resting periods, locomotor time 1	0.1	0.1	0.4	0.3	-0.6	-0.2	-0.2	0.2	0.4
Rest time, locomotor task time 1	1.9	2.1	2.6	1.5	-1.6	-1.3	-1.4	1.3	1.5
Distance moved, locomotor task time 1	2.2	2.4	3.5	-1.5	1.9	1.4	1.4	-1.4	-1.6
Vertical activity count, locomotor time 1	1.8	1.9	3.1	-1.4	1.8	1.2	1.2	-1.2	-1.4
Time >=10cm from walls, locomotor time 2	0.8	0.8	1.0	1.0	-1.0	-0.9	-0.8	0.9	0.9
Bouts of movement, locomotor time 2	0.2	0.2	0.3	-0.4	0.0	0.5	0.5	-0.5	-0.4
Total resting periods, locomotor time 2	0.0	0.0	0.2	0.1	-0.5	-0.0	-0.0	0.0	0.1
Rest time, locomotor task time 2	4.2	4.8	5.0	2.2	-2.2	-2.2	-2.2	2.2	2.2
Distance moved, locomotor task time 2	2.3	2.7	3.1	-1.6	1.8	1.6	1.6	-1.6	-1.6
Vertical activity count, locomotor time 2	0.8	0.9	1.7	-1.0	1.3	0.7	0.7	-0.7	-0.9
Light reinforcement 1	2.2	4.1	5.7	-2.4	2.2	1.8	1.8	-1.7	-2.0
Light reinforcement 2	0.1	0.2	0.2	0.3	-0.4	-0.4	-0.5	0.5	0.4
Bone: marrow area	0.2	0.4	0.6	-0.6	0.4	0.7	0.7	-0.7	-0.6
Bone: maximum diameter	0.4	0.8	0.9	0.9	-0.8	-0.9	-0.9	0.9	0.9
Bone: maximum force	0.1	0.2	0.3	-0.4	0.2	0.5	0.5	-0.5	-0.4
Bone: maximum moment	0.2	0.4	0.5	-0.6	0.5	0.7	0.7	-0.7	-0.6
Mean time between licks in bursts	0.1	0.1	0.1	0.3	-0.2	-0.3	-0.3	0.3	0.3
Mean num. licks in bursts	2.3	2.7	3.0	-1.7	1.7	1.6	1.6	-1.6	-1.6
Cd content in liver	0.5	0.6	0.6	-0.8	0.7	0.7	0.7	-0.7	-0.8
Co content in liver	0.1	0.2	0.2	-0.3	0.1	0.5	0.5	-0.5	-0.4
Cu content in liver	0.2	0.3	0.6	-0.6	0.8	0.4	0.4	-0.4	-0.5
Fe content in liver	1.6	1.9	2.4	-1.5	1.6	1.3	1.3	-1.3	-1.4
K content in liver	2.7	2.6	3.3	-1.5	1.1	1.8	1.8	-1.8	-1.6
Mg content in liver	0.4	0.5	0.7	-0.5	0.1	0.8	0.8	-0.9	-0.6
Mn content in liver	0.4	0.4	0.6	-0.7	0.8	0.6	0.6	-0.6	-0.6
Na content in liver	0.2	0.2	0.3	-0.5	0.4	0.5	0.5	-0.5	-0.5
Rb content in liver	0.9	1.1	1.2	-1.0	1.1	1.0	1.0	-1.0	-1.0
Se content in liver	0.1	0.2	0.2	0.4	-0.3	-0.4	-0.4	0.4	0.4
Sr content in liver	2.6	2.4	3.5	1.7	-1.9	-1.4	-1.4	1.3	1.5
Zn content in liver	0.0	0.0	0.0	0.0	-0.2	0.1	0.1	-0.1	-0.0
Bone: minimum diameter	2.0	3.7	3.9	-2.0	1.9	1.9	1.9	-1.9	-1.9
Time in familiar zone, hab. session 1	4.7	4.4	4.6	-2.1	2.1	2.1	2.1	-2.1	-2.1
Time in novel zone, hab. session 1	6.5	6.4	6.6	2.6	-2.5	-2.5	-2.5	2.5	2.5
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.1	-0.1	0.2	0.2	-0.2	-0.2
Total locomotion distance, hab. session 1	0.1	0.1	0.1	-0.1	-0.3	0.3	0.3	-0.4	-0.2
Locomotion velocity, hab. session 1	0.0	0.1	0.1	-0.1	-0.2	0.3	0.3	-0.3	-0.1
Time in familiar zone, hab. session 2	1.6	1.7	1.9	-1.3	1.2	1.4	1.3	-1.4	-1.3
Time in novel zone, hab. session 2	2.1	2.1	2.3	1.5	-1.3	-1.5	-1.4	1.5	1.4
Total zone transitions, hab. session 2	0.1	0.2	0.2	-0.4	0.3	0.4	0.4	-0.4	-0.4
Total locomotion distance, hab. session 2	0.1	0.1	0.3	0.2	-0.6	-0.0	-0.1	0.0	0.2
Locomotion velocity, hab. session 2	0.0	0.1	0.1	-0.2	-0.2	0.3	0.3	-0.3	-0.2
Novel to familiar place preference ratio	2.2	2.3	2.4	1.5	-1.6	-1.5	-1.4	1.5	1.5
Novelty place preference	1.7	1.7	1.8	1.3	-1.3	-1.3	-1.3	1.4	1.3
Time in novel zone, NPP test	1.8	1.9	2.1	1.4	-1.3	-1.4	-1.3	1.4	1.4
Total zone transitions, NPP test	1.5	2.2	2.4	-1.5	1.4	1.5	1.4	-1.5	-1.5
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.3	0.0	0.4	0.4	-0.5	-0.3
Locomotion velocity, NPP test	0.6	0.8	1.0	-0.9	0.6	1.0	0.9	-1.0	-0.9
Intraocular pressure	4.0	5.5	6.5	2.3	-1.8	-2.5	-2.5	2.5	2.3
Delta distance traveled before/after self-admin	0.4	0.4	0.6	-0.8	0.7	0.6	0.6	-0.6	-0.6
Delta ambulatory time before/after self-admin	0.5	0.5	0.6	-0.8	0.6	0.8	0.7	-0.8	-0.7
Parametrial fat weight	0.0	0.0	0.0	0.1	0.1	-0.2	-0.2	0.2	0.1
Pavlov. Cond. lever latency	0.0	0.1	0.1	0.1	-0.0	-0.3	-0.3	0.3	0.2
Pavlov. Cond. magazine entry latency	2.2	2.9	3.6	-1.6	1.3	1.9	1.8	-1.9	-1.6
Pavlov. Cond. change in total contacts	3.5	3.7	4.1	-1.9	1.7	2.0	2.0	-2.0	-1.9
Pavlov. Cond. index score	0.6	0.7	1.0	-0.7	0.5	1.0	1.0	-1.0	-0.8
Pavlov. Cond. latency score	0.2	0.2	0.4	-0.4	0.2	0.6	0.6	-0.6	-0.4
Pavlov. Cond. lever contacts	0.5	0.6	0.7	-0.6	0.5	0.8	0.9	-0.9	-0.7
Pavlov. Cond. magazine entry number	2.4	2.9	3.8	1.5	-1.2	-1.9	-1.9	1.9	1.6
Pavlov. Cond. intertrial magazine entries	5.4	6.5	7.2	2.5	-2.2	-2.7	-2.6	2.7	2.5
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.3	-0.9	0.7	1.1	1.1	-1.1	-0.9
Pavlov. Cond. response bias	2.3	2.8	3.4	-1.6	1.3	1.8	1.8	-1.8	-1.6
Pavlov. Cond. lever latency	1.8	2.4	2.7	1.5	-1.3	-1.6	-1.6	1.6	1.5
Pavlov. Cond. magazine entry latency	0.9	1.1	1.5	-0.9	0.6	1.2	1.1	-1.2	-1.0
Pavlov. Cond. change in total contacts	5.1	7.0	7.5	-2.7	2.4	2.7	2.7	-2.7	-2.6
Pavlov. Cond. index score	2.5	3.2	3.8	-1.7	1.4	1.9	1.9	-1.9	-1.8
Pavlov. Cond. latency score	2.6	3.2	3.8	-1.7	1.4	1.9	1.9	-1.9	-1.8
Pavlov. Cond. lever contacts	1.9	2.6	2.8	-1.6	1.5	1.7	1.6	-1.7	-1.6
Pavlov. Cond. magazine entry number	1.8	2.2	2.9	1.4	-1.0	-1.7	-1.6	1.7	1.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	-0.4	0.7	0.1	0.1	-0.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.3	4.0	-1.8	1.5	2.0	1.9	-2.0	-1.8
Pavlov. Cond. response bias	1.6	2.2	2.5	-1.4	1.3	1.6	1.5	-1.6	-1.4
Time in closed arm before self-admin	0.0	0.0	0.1	-0.2	0.4	0.1	0.2	-0.1	-0.2
Time in closed arm after self-admin	0.5	0.5	0.8	0.9	-0.9	-0.6	-0.6	0.6	0.7
Time in open arm before self-admin	0.1	0.1	0.2	-0.2	0.0	0.4	0.4	-0.5	-0.3
Time in open arm after self-admin	0.3	0.4	0.5	0.5	-0.5	-0.7	-0.7	0.7	0.6
Bone: periosteal estimation	0.2	0.3	0.3	-0.6	0.6	0.6	0.6	-0.6	-0.5
Bone: periosteal perimeter	0.0	0.0	0.1	-0.1	0.1	0.2	0.2	-0.2	-0.2
Bone: post-yield work	0.0	0.0	0.0	-0.0	0.1	-0.0	-0.1	0.0	0.0
Progressive ratio test 1 active lever presses	0.9	0.9	1.0	-0.9	1.0	0.9	1.0	-0.9	-1.0
Progressive ratio test 1 breakpoint	1.0	1.1	1.3	-0.9	1.0	1.0	1.1	-1.0	-1.1
Progressive ratio test 1 inactive lever presses	0.5	0.5	0.6	-0.7	0.8	0.7	0.8	-0.7	-0.8
Progressive ratio test 2 active lever presses	0.3	0.3	0.4	-0.5	0.6	0.5	0.5	-0.5	-0.5
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	-0.4	0.5	0.4	0.4	-0.4	-0.4
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	-0.4	0.7	0.3	0.3	-0.2	-0.4
Incentive Sensitization - Responses	0.6	0.6	0.8	-0.8	0.9	0.7	0.7	-0.7	-0.7
Incentive Sensitization - Breakpoint	0.3	0.4	0.5	-0.6	0.7	0.6	0.5	-0.5	-0.6
Sum of active levers in priming session hrs 5-6	1.0	1.0	1.1	1.0	-0.8	-1.0	-1.0	1.0	1.0
Progressive ratio	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	0.1
Food seeking constrained by brief footshock	2.4	2.9	3.2	-1.7	1.6	1.8	1.8	-1.8	-1.7
Seeking ratio, punishment vs. effort	0.7	0.9	1.0	-1.0	1.0	1.0	1.0	-0.9	-0.9
Retroperitoneal fat weight	0.7	2.2	2.7	1.4	-1.1	-1.6	-1.6	1.6	1.5
Reaction time number correct	9.2	13.3	14.0	-3.7	3.6	3.7	3.6	-3.6	-3.6
Reaction time mean minus median	0.1	0.1	0.1	-0.2	0.3	0.3	0.3	-0.3	-0.2
Reaction time mean minus median AUC	0.4	0.5	0.6	-0.6	0.8	0.7	0.6	-0.7	-0.7
Reaction time num false alarms	0.6	0.8	0.8	0.9	-0.9	-0.9	-0.8	0.9	0.9
Reaction time num false alarms AUC	1.1	1.5	1.6	1.2	-1.2	-1.2	-1.2	1.2	1.2
Reaction time trials correct on left	9.2	13.3	14.0	-3.7	3.6	3.7	3.6	-3.6	-3.6
Reaction time trials on left	9.5	13.5	14.3	-3.8	3.7	3.7	3.6	-3.7	-3.6
Reaction time mean	1.6	2.2	2.6	1.5	-1.6	-1.4	-1.5	1.5	1.5
Reaction time mean AUC	1.4	1.9	2.3	1.4	-1.5	-1.3	-1.4	1.3	1.4
Median of all reaction times	2.8	3.8	4.5	1.9	-2.1	-1.9	-1.9	1.9	1.9
Reaction time omissions	0.1	0.2	0.4	-0.5	0.7	0.3	0.3	-0.3	-0.4
Reaction time false alarm rate	6.1	8.6	9.1	3.0	-2.9	-2.9	-2.9	2.9	2.9
Reaction time premature initiation rate	3.9	5.2	5.6	-2.3	2.1	2.4	2.3	-2.3	-2.3
Reaction time premature initiations	11.6	16.3	17.0	-4.1	3.9	4.1	4.0	-4.1	-4.0
Std. dev. reaction times	0.1	0.1	0.1	0.3	-0.3	-0.2	-0.3	0.3	0.3
Reaction time trials completed	9.5	13.5	14.3	-3.8	3.7	3.7	3.6	-3.7	-3.6
Reaction time trials AUC	8.5	12.3	13.1	-3.6	3.5	3.5	3.5	-3.5	-3.5
Run reversals in cocaine runway, females	0.7	0.7	0.9	0.7	-0.7	-0.8	-0.9	0.9	0.8
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.3	-0.5	0.2	0.2	-0.2	0.0
Latency to leave start box in cocaine runway	2.5	2.7	2.8	1.6	-1.7	-1.6	-1.7	1.6	1.6
Latency to leave start box in cocaine runway, F	0.3	0.4	0.5	0.5	-0.5	-0.6	-0.7	0.6	0.6
Latency to leave start box in cocaine runway, M	2.8	2.7	3.3	1.7	-1.8	-1.5	-1.6	1.5	1.6
Std. dev. time between licks in bursts	1.1	1.3	1.6	1.2	-1.2	-1.1	-1.1	1.1	1.1
Total sessions with >9 infusions	0.7	0.7	1.0	-0.8	0.8	0.8	1.0	-0.8	-0.9
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.2	0.4	-0.0	0.0	0.0	-0.1
Short access day 10 total inactive lever presses	0.6	0.6	0.9	0.9	-0.9	-0.7	-0.8	0.7	0.8
Short access day 1 total infusions	1.2	1.3	1.6	-1.1	1.3	1.0	1.2	-1.0	-1.2
Short access day 10 total infusions	1.3	1.4	1.7	-1.1	1.1	1.2	1.3	-1.2	-1.2
Short access total infusions	1.7	2.0	2.2	-1.3	1.5	1.3	1.5	-1.3	-1.5
Short access day 1 locomotion	0.3	0.3	0.6	-0.5	0.8	0.4	0.5	-0.4	-0.6
Short access day 10 total locomotion	0.0	0.0	0.0	-0.0	0.2	-0.1	-0.0	0.2	-0.0
Short access total locomotion	1.7	1.8	2.8	-1.3	1.7	1.1	1.3	-1.1	-1.4
One hour access (0.3 mA shock)	1.0	1.2	1.6	-1.2	1.3	1.0	1.0	-1.0	-1.1
Compulsive drug intake	0.2	0.2	0.2	0.4	-0.2	-0.4	-0.5	0.5	0.4
One hour access (shock baseline)	2.1	2.4	2.5	-1.6	1.6	1.5	1.6	-1.5	-1.6
Social response proportion	0.1	0.1	0.1	0.2	-0.1	-0.3	-0.3	0.3	0.3
Social responses	1.3	1.7	2.1	-1.3	1.0	1.4	1.4	-1.3	-1.3
Social time	0.0	0.0	0.0	-0.0	0.2	-0.1	-0.1	0.2	0.1
Soleus weight	0.2	0.5	0.6	0.7	-0.4	-0.8	-0.8	0.8	0.7
Bone: stiffness	0.3	0.5	0.7	-0.6	0.4	0.8	0.8	-0.8	-0.7
Tibialis anterior weight	2.3	8.0	8.4	2.9	-2.7	-2.9	-2.9	2.8	2.8
Time to tail flick, vehicle, before self-admin	4.4	4.5	5.5	-2.4	2.2	2.1	2.0	-2.0	-2.1
Time to tail flick, vehicle, after self-admin	1.8	1.9	2.3	-1.3	1.0	1.5	1.5	-1.5	-1.4
Time to tail flick, test, before self-admin	0.2	0.2	0.3	-0.5	0.5	0.3	0.3	-0.3	-0.4
Time to tail flick, test, after self-admin	0.6	0.6	1.0	0.6	-0.2	-0.9	-1.0	1.0	0.7
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	1.8	1.2	-1.3	-0.9	-0.9	0.9	1.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.3	-0.1	-0.3	-0.3	0.3	0.2
Tibia length	6.3	17.9	20.0	-4.5	4.5	4.1	4.1	-4.0	-4.2
Ambulatory time before self-admin	0.7	0.7	0.8	-0.8	0.8	0.8	0.9	-0.8	-0.9
Ambulatory time after self-admin	0.9	1.0	1.2	-1.0	0.9	1.1	1.0	-1.1	-1.0
Bone: tissue strength	1.1	1.1	1.1	1.0	-1.0	-1.0	-1.1	1.1	1.0
Total heroin consumption	1.5	1.8	2.1	1.4	-1.2	-1.4	-1.3	1.4	1.3
Bone: trabecular number	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.1	0.1	0.2
Bone: trabecular spacing	0.1	0.1	0.2	0.0	0.4	-0.4	-0.4	0.4	0.2
Bone: trabecular thickness	1.1	1.3	2.0	1.2	-1.4	-1.0	-1.1	1.0	1.1
Bone: trabecular tissue density	2.3	3.3	3.5	1.8	-1.8	-1.8	-1.9	1.7	1.8
Water consumed over 24 hours	0.6	0.7	0.8	0.9	-0.8	-0.9	-0.9	0.9	0.9
Number of responses in last shaping day	0.4	0.5	0.6	0.8	-0.6	-0.7	-0.6	0.7	0.6