LOC120100693

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	LOC120100693	0.11	0.06	1.5e-05	0.09	0.03	0.03	0.06	1.0e-05	6.3e-03	1.2e-02	3.4e-04
2	Adipose	gene expression	LOC120100693	0.58	0.09	0.0e+00	0.42	0.4	0.43	0.43	5.1e-50	7.4e-47	1.0e-51	1.7e-51
3	pVTA	gene expression	LOC120100693	0.26	0.11	1.5e-09	0.2	0.19	0.21	0.2	7.1e-09	1.0e-08	2.7e-09	2.9e-09
4	Brain	gene expression	LOC120100693	0.09	0.04	7.8e-11	0.09	0.12	0.11	0.1	1.8e-08	4.3e-11	4.5e-10	1.9e-09
5	RMTg	gene expression	LOC120100693	0.17	0.1	2.1e-04	0.06	0.12	-0	0.08	1.2e-02	3.6e-04	4.5e-01	4.2e-03
6	Brain	intron excision ratio	chr2_33607297_33681990	0.06	0.05	8.0e-04	0	0.02	0.01	0.01	1.0e-01	7.1e-03	2.2e-02	4.0e-02
7	NAcc	gene expression	LOC120100693	0.1	0.09	9.1e-06	0.05	0.02	0.04	0.04	3.6e-06	8.2e-04	6.1e-05	6.6e-06
8	PL	gene expression	LOC120100693	0.03	0.02	1.9e-03	0.01	0.03	0.02	0.01	2.8e-02	5.9e-04	5.5e-03	2.0e-02
9	LHb	gene expression	LOC120100693	0.63	0.11	2.3e-08	0.17	0.18	0.18	0.22	9.7e-05	5.0e-05	3.6e-05	7.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.5	0.8	4.3	-0.3	-0.6	-0.4	1.0	2.1	-0.0	-0.2	0.8	-1.0
Area under the delay curve	0.8	0.8	2.3	0.9	0.7	0.7	-0.8	-0.5	-0.7	0.8	-1.2	-1.5
BMI with tail	1.0	3.3	11.2	-1.4	-1.3	-1.4	2.3	3.3	0.7	-1.2	2.3	-0.5
BMI without tail	0.5	1.1	2.6	-0.9	-1.1	-0.8	1.1	1.6	0.2	-0.8	0.5	-1.5
Body weight	1.4	5.7	8.4	2.7	2.6	2.7	-2.2	-1.1	-2.9	2.8	-1.9	-2.0
Weight adjusted by age	0.7	0.8	1.4	0.8	1.0	0.8	-0.9	-1.2	-0.3	1.1	-0.9	0.3
Bone surface	0.6	1.0	4.7	-0.5	-0.5	-0.5	1.1	2.2	-0.6	-0.3	1.4	0.0
Bone volume	0.7	1.2	5.0	-0.8	-1.0	-0.8	1.2	2.2	-0.2	-0.7	1.0	-0.6
Breakpoint value in progressive ratio session	1.7	1.9	2.3	-1.3	-1.4	-1.4	1.5	1.3	1.3	-1.4	1.5	1.0
Number of licking bursts	4.4	5.2	6.5	-2.5	-2.5	-2.5	2.5	2.5	1.8	-2.4	2.2	1.3
Context. condit. distance diff. score	1.4	1.7	2.7	1.5	1.4	1.5	-1.3	-0.7	-1.6	1.4	-0.9	-1.1
Locomotion velocity, session 1	0.3	0.3	1.3	0.1	0.2	0.0	-0.5	-1.1	0.4	0.1	-0.6	0.7
Locomotion distance, session 1	0.1	0.1	0.3	0.3	0.3	0.2	-0.3	-0.5	-0.1	0.2	-0.4	0.3
Locomotion velocity, session 2	2.2	2.6	6.5	1.5	1.6	1.5	-2.0	-2.5	-0.7	1.4	-1.8	0.3
Locomotion distance, session 2	0.2	0.3	1.1	0.4	0.6	0.4	-0.6	-1.1	0.2	0.4	-0.4	0.4
Locomotion velocity, session 3	4.5	5.2	6.7	2.3	2.1	2.3	-2.6	-2.3	-2.2	2.1	-2.5	-2.0
Locomotion distance, session 3	4.4	4.8	7.2	2.2	2.3	2.4	-2.3	-2.1	-2.7	2.2	-1.9	-1.3
Stereotopy head waving bouts, day 3	0.2	0.3	0.8	0.4	0.3	0.4	-0.6	-0.6	-0.4	0.3	-0.9	-0.6
Stereotopy head waving duration, day 3	0.1	0.1	0.4	-0.1	-0.2	-0.1	-0.1	0.0	-0.1	-0.3	-0.5	-0.7
Locomotion velocity, session 7	1.5	1.6	3.0	1.3	1.2	1.4	-1.3	-1.0	-1.7	1.2	-1.0	-1.3
Locomotion distance, session 7	2.5	3.1	4.3	2.0	1.9	2.1	-1.6	-1.0	-2.1	2.0	-1.1	-1.9
Stereotopy head waving bouts, day 7	1.3	1.5	2.5	-1.4	-1.5	-1.3	1.3	1.2	0.7	-1.6	0.9	0.4
Stereotopy head waving duration, day 7	0.4	0.5	1.2	-0.8	-1.0	-0.9	0.7	0.5	0.4	-1.1	0.3	0.3
Locomotion velocity, session 8	2.5	3.0	6.3	1.5	1.3	1.4	-2.0	-2.0	-1.0	1.5	-2.5	-1.7
Locomotion distance, session 8	2.1	3.0	3.7	1.9	1.8	1.9	-1.9	-1.5	-1.9	1.8	-1.6	-1.2
Degree of sensitization distance	0.3	0.3	0.7	-0.2	-0.4	-0.4	0.6	0.8	0.7	-0.2	0.3	-0.7
Degree of sensitization stereotypy	1.3	1.4	2.3	-1.4	-1.4	-1.3	1.3	1.2	0.7	-1.5	1.0	0.4
Conditioned locomotion	0.3	0.4	1.9	-0.5	-0.3	-0.4	0.4	0.5	-0.1	-0.3	0.8	1.4
Cocaine response after cond. corrected	1.5	1.7	3.3	1.3	1.6	1.5	-1.2	-1.2	-1.8	1.4	-0.8	0.5
Cocaine response after cond. not corrected	2.0	2.2	3.1	1.6	1.7	1.6	-1.5	-1.4	-1.8	1.7	-1.4	-0.0
Cocaine response before conditioning	0.4	0.5	1.3	0.6	0.3	0.4	-0.7	-0.5	0.2	0.7	-1.1	-1.1
Saline control response	0.4	0.6	1.4	0.8	0.9	0.9	-0.8	-0.5	-0.7	1.2	-0.4	0.2
Bone: connectivity density	0.4	0.6	2.2	0.4	0.4	0.4	0.4	1.5	-1.0	0.7	0.6	-0.4
Bone: cortical apparent density	0.7	0.9	1.8	1.0	1.2	0.8	-1.0	-1.3	0.4	1.2	-0.6	0.5
Bone: cortical area	0.2	0.3	1.0	0.5	0.3	0.5	-0.2	0.2	-1.0	0.3	-0.2	-0.7
Bone: cortical porosity	2.2	2.4	4.0	-1.8	-2.0	-1.7	1.7	2.0	0.6	-1.6	0.4	-1.3
Bone: cortical porosity	2.0	2.2	3.9	-1.7	-1.9	-1.6	1.6	2.0	0.6	-1.5	0.4	-1.4
Bone: cortical thickness	0.1	0.2	0.5	0.5	0.5	0.4	-0.3	-0.2	-0.7	0.5	-0.5	-0.3
Bone: cortical thickness	1.3	1.5	2.7	1.5	1.5	1.4	-0.9	-0.3	-1.6	1.5	-0.7	-0.8
Bone: cortical tissue density	0.7	0.9	1.8	1.1	1.2	0.8	-1.0	-1.3	0.3	1.2	-0.6	0.5
Condit. Reinf. active minus inactive responses	2.1	2.3	3.4	-1.6	-1.7	-1.8	1.8	1.7	1.7	-1.5	0.9	-0.4
Condit. Reinf. active-inactive response ratio	2.6	2.8	3.9	-1.8	-1.9	-2.0	1.9	1.7	1.9	-1.7	1.2	-0.2
Condit. Reinf. active responses	0.3	0.3	0.5	-0.6	-0.7	-0.7	0.6	0.6	0.5	-0.5	0.1	-0.7
Condit. Reinf. inactive responses	1.7	2.0	3.0	1.3	1.3	1.6	-1.6	-1.5	-1.7	1.3	-1.4	-0.8
Incentive salience index mean	2.6	3.2	5.1	-2.1	-2.2	-2.3	1.9	1.5	2.1	-1.9	0.8	0.1
Condit. Reinf. lever presses	1.2	1.6	2.4	-1.5	-1.5	-1.6	1.3	0.8	1.5	-1.3	0.6	0.9
Condit. Reinf. active minus inactive responses	1.6	2.0	4.5	1.3	1.1	1.3	-1.9	-2.1	-0.6	1.1	-1.9	-0.3
Condit. Reinf. active-inactive response ratio	1.4	1.5	3.4	1.1	1.0	1.1	-1.6	-1.8	-0.6	0.9	-1.6	-0.4
Condit. Reinf. active responses	0.3	0.4	1.2	0.4	0.2	0.3	-0.9	-1.1	0.0	0.1	-1.0	0.3
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.3	-0.4	-0.4	0.2	0.3	0.1	-0.6	0.2	0.5
Condit. Reinf. lever presses	0.5	0.7	1.4	0.9	0.8	0.7	-1.1	-1.2	-0.3	0.7	-1.1	0.3
Condit. Reinf. lever reinforcers received	0.4	0.5	1.7	0.5	0.4	0.5	-1.0	-1.3	-0.1	0.2	-1.0	0.5
Conditioned reinforcement - actives	0.6	0.6	1.5	0.6	1.0	0.8	-0.4	-0.5	-1.2	0.6	0.2	0.8
Conditioned reinforcement - inactives	1.2	1.3	2.6	1.3	1.6	1.4	-1.0	-1.1	-1.3	1.1	0.1	0.8
Conditioned locomotion	0.7	0.9	1.5	0.9	1.2	1.2	-0.9	-1.0	-1.0	0.8	0.1	0.9
Patch foraging indifference point 0 sec	2.2	3.5	5.8	2.2	2.4	2.2	-1.7	-1.1	-2.3	2.3	-1.0	0.0
Patch foraging indifference point AUC	1.8	2.1	3.8	-1.8	-1.7	-1.9	1.3	1.1	1.6	-1.7	0.6	0.4
Delay disc. indifference point, 0s delay	0.7	0.8	4.5	0.5	0.0	0.3	-0.5	-0.2	-0.1	0.5	-1.3	-2.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	0.4	0.4	0.3	-0.3	-0.3	-0.6	0.3	-0.4	-0.2
Delay disc. indifference point, 2s delay	0.8	0.9	2.0	0.9	0.7	0.7	-0.9	-0.7	-0.7	0.9	-1.2	-1.4
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	-0.4	-0.3	-0.6	0.3	-0.1	0.4	-0.5	-0.0	0.6
Delay disc. indifference point, 4s delay	1.2	1.3	3.5	1.2	0.9	1.0	-1.1	-0.7	-0.6	1.1	-1.3	-1.9
Delay disc. indifference point, 8s delay	0.2	0.2	0.7	0.3	0.4	0.2	-0.4	-0.3	-0.0	0.3	-0.6	-0.8
Indifference point function ln k	1.5	2.0	2.9	1.7	1.7	1.7	-1.5	-1.7	-1.2	1.5	-1.1	-0.1
Indifference point function log k	1.5	2.0	2.9	1.7	1.7	1.7	-1.5	-1.7	-1.2	1.5	-1.1	-0.1
Patch foraging total patch changes 0 sec	2.7	4.4	7.1	2.5	2.7	2.4	-1.9	-1.4	-2.5	2.6	-1.2	-0.0
Patch foraging total patch changes 12 sec	0.2	0.2	0.5	-0.4	-0.2	-0.5	0.6	0.7	0.1	-0.3	0.7	0.6
Patch foraging total patch changes 18 sec	0.1	0.2	0.6	0.1	0.2	-0.0	0.3	0.8	-0.5	-0.1	0.6	0.2
Patch foraging total patch changes 24 sec	0.3	0.3	0.7	0.7	0.8	0.7	-0.5	-0.4	-0.5	0.6	-0.0	0.6
Patch foraging total patch changes 6 sec	0.5	0.7	1.7	1.0	1.1	0.8	-0.7	-0.3	-1.3	0.9	-0.4	0.2
Patch foraging time to switch 0 sec	2.3	3.5	5.8	-1.7	-1.8	-1.8	2.1	2.4	1.8	-1.8	2.3	0.4
Patch foraging water rate 0 sec	1.3	2.1	3.5	1.3	1.5	1.4	-1.5	-1.9	-1.6	1.4	-1.5	0.3
Patch foraging water rate 12 sec	2.1	3.2	7.0	1.7	1.8	2.0	-1.8	-1.6	-2.6	1.7	-1.6	-0.1
Patch foraging water rate 18 sec	2.6	3.5	5.8	2.0	2.0	2.0	-2.1	-2.4	-1.8	1.8	-1.7	0.6
Patch foraging water rate 24 sec	1.5	2.1	5.4	1.4	1.7	1.7	-1.1	-1.3	-2.3	1.1	-0.2	1.3
Patch foraging water rate 6 sec	8.6	12.6	15.5	3.9	3.7	3.8	-3.8	-3.7	-3.5	3.9	-3.6	-1.1
Seeking ratio, delayed vs. immediate footshock	2.3	2.6	4.9	-1.7	-1.2	-1.3	2.0	2.2	-0.0	-1.5	2.2	1.2
Distance traveled before self-admin	0.6	0.7	2.9	0.3	0.7	0.4	-0.5	-0.9	-0.8	0.8	-0.3	1.7
Distance traveled after self-admin	0.9	1.0	2.1	0.9	1.1	0.8	-0.9	-1.2	-0.6	1.3	-0.5	1.4
Extensor digitorum longus weight	2.4	9.5	15.5	-3.1	-2.9	-2.9	3.5	3.4	2.5	-3.2	3.9	1.6
Bone: elastic displacement	0.2	0.3	1.8	-0.3	-0.4	-0.4	0.4	0.0	1.3	-0.1	0.3	0.2
Bone: elastic work	0.6	0.8	1.1	-0.8	-0.7	-0.9	1.1	1.0	1.0	-0.6	0.9	0.6
Bone: endosteal estimation	0.1	0.3	1.1	0.3	-0.0	0.4	-0.2	0.5	-1.0	0.1	-0.2	-1.1
Bone: endosteal perimeter	0.1	0.3	0.9	0.2	-0.1	0.2	0.2	0.9	-0.7	-0.0	0.5	-0.8
Epididymis fat weight	0.2	0.5	1.5	0.8	0.8	0.7	-0.2	0.2	-0.5	0.8	0.5	1.2
Delta time in closed arm before/after self-admin	5.1	5.0	6.2	-2.3	-2.3	-2.3	2.4	2.5	2.4	-2.1	2.4	0.9
Delta time in open arm before/after self-admin	0.1	0.1	0.6	0.2	0.4	0.4	-0.3	-0.3	-0.7	0.2	-0.3	-0.2
Diff in mean of infusions in LGA sessions	0.7	0.8	1.4	-1.0	-1.0	-1.1	0.4	-0.4	1.2	-1.2	0.0	0.8
Delay discount exponential model param	0.8	0.8	1.7	-0.9	-0.8	-0.7	0.9	0.7	0.7	-0.8	1.1	1.3
Extinction: sum of active levers before priming	1.3	1.3	2.4	-1.2	-0.8	-0.9	1.2	0.9	0.7	-1.0	1.6	1.5
Active lever presses in extinction session 6	1.0	1.0	1.7	-1.0	-0.8	-1.0	1.1	1.0	0.5	-0.8	1.1	1.3
Bone: final force	0.3	0.5	1.1	0.8	0.5	0.7	-0.6	-0.1	-0.9	0.7	-0.6	-1.1
Bone: final moment	0.3	0.6	1.2	0.8	0.6	0.8	-0.6	-0.2	-1.1	0.7	-0.5	-1.0
Food consumed during 24 hour testing period	0.3	0.4	1.0	0.7	0.5	0.3	-0.7	-0.5	-0.4	0.7	-1.0	-0.1
Glucose	0.4	0.7	4.2	-0.2	-0.5	-0.2	-0.0	0.7	-0.6	0.0	-0.7	-2.1
Heart weight	0.2	0.2	0.8	-0.2	-0.3	-0.2	0.5	0.7	0.6	-0.3	0.9	0.0
Delay discount hyperbolic model param	1.0	1.1	2.1	-1.1	-1.0	-0.9	1.0	0.8	0.8	-1.0	1.3	1.4
Intermittent access intake day 1-15 change	0.5	0.4	1.1	0.9	0.8	0.5	-0.4	0.1	-0.9	1.0	-0.5	-0.4
Intermittent access intake escalation	0.9	0.8	1.9	1.2	1.1	0.9	-0.7	-0.3	-1.1	1.4	-0.6	-0.3
Intermittent access intake escalation 2	0.4	0.4	0.8	0.8	0.8	0.5	-0.2	0.4	-0.8	0.9	-0.1	-0.3
Intermitt. access day 1 inactive lever presses	2.1	2.2	3.1	-1.7	-1.5	-1.4	1.5	1.6	1.0	-1.8	1.6	1.1
Intermitt. access day 15 inactive lever presses	0.3	0.3	1.3	-0.1	-0.1	0.1	0.5	1.1	-0.4	-0.4	1.0	-0.4
Intermitt. access escalation Index	0.3	0.3	0.6	-0.4	-0.8	-0.8	0.2	0.1	0.6	-0.4	-0.6	0.2
Intermittent access day 1 total infusions	0.7	0.8	2.2	1.0	1.1	1.1	-0.8	-0.7	-1.5	0.5	0.0	0.7
Intermittent access day 15 total infusions	1.9	2.1	4.3	1.8	1.8	1.7	-1.3	-1.0	-2.1	1.5	-0.7	-0.1
Intermittent access terminal intake (last 3 days)	1.5	1.6	3.8	1.6	1.5	1.5	-1.0	-0.4	-1.9	1.4	-0.5	-0.4
Intermittent access total infusions	2.1	2.4	4.4	1.9	1.9	1.9	-1.5	-1.2	-2.1	1.4	-0.7	0.2
Intermittent access day 1 locomotion	1.1	1.2	2.7	1.0	1.0	1.2	-1.3	-1.6	-1.1	0.7	-1.0	0.3
Intermittent access day 15 total locomotion	2.2	2.4	3.4	1.8	1.8	1.7	-1.6	-1.7	-1.6	1.5	-1.1	0.5
Intermittent access total locomotion	2.6	2.9	4.2	1.9	1.9	1.9	-1.9	-2.0	-1.9	1.5	-1.3	0.6
Intermittent access standard deviation	0.6	0.7	3.7	0.9	0.4	0.7	-0.4	0.4	-0.4	0.7	-0.1	-1.9
Left kidney weight	1.0	2.9	5.3	2.1	2.0	2.1	-1.6	-1.0	-2.3	1.7	-0.8	-0.4
Right kidney weight	0.8	2.2	4.3	1.9	1.8	2.0	-1.2	-0.6	-2.1	1.6	-0.2	-0.4
Cocaine induced anxiety	0.4	0.5	2.7	-0.3	-0.0	-0.1	-0.4	-1.2	0.0	-0.3	-0.3	1.7
Post-drug Anxiety	0.7	0.8	3.2	0.3	0.5	0.6	-1.0	-1.8	-0.5	0.2	-0.9	0.9
Baseline Anxiety	0.4	0.4	2.1	0.3	-0.0	0.1	-0.3	-0.5	0.7	0.2	-0.7	-1.4
Tail length	4.3	13.1	18.7	3.5	3.4	3.6	-4.1	-4.3	-3.7	3.5	-4.1	-1.7
Length with tail	7.4	27.0	34.1	5.5	5.4	5.5	-5.8	-5.8	-5.1	5.5	-5.2	-1.7
Length without tail	4.8	10.5	13.9	3.7	3.7	3.5	-3.6	-3.4	-3.1	3.7	-2.7	-0.1
Times rat made contact with spout	0.1	0.1	0.5	-0.1	-0.3	-0.2	0.3	0.7	0.1	-0.3	0.5	-0.2
Lifetime Intake	2.2	2.4	5.2	1.9	1.9	1.9	-1.5	-1.2	-2.3	1.4	-0.6	0.3
Liver weight, left	2.4	3.9	6.5	2.3	2.1	2.1	-1.7	-0.7	-2.5	2.2	-1.8	-1.7
Liver weight, right	0.5	0.8	1.9	1.1	0.7	0.8	-0.4	0.7	-1.4	0.9	-0.3	-1.1
Locomotor activity	0.3	0.5	0.9	-0.8	-0.9	-0.7	0.6	0.4	0.7	-0.9	0.5	0.5
Locomotor testing distance	1.4	2.4	3.3	-1.7	-1.5	-1.5	1.5	1.1	1.8	-1.8	1.6	1.1
Locomotor testing rearing	0.7	1.1	1.7	-1.1	-1.0	-1.0	1.1	1.3	0.3	-1.2	1.3	1.0
Locomotion in novel chamber	1.8	2.3	3.9	-1.4	-1.6	-1.6	1.8	2.0	1.3	-1.6	1.4	0.5
Locomotion in novel chamber post-restriction	0.9	1.1	4.3	1.2	0.9	1.3	-0.8	-0.1	-0.3	1.1	-0.4	-2.1
Fecal boli incidents, locomotor time 1	3.3	3.6	4.3	-2.0	-1.9	-2.0	2.0	1.8	1.7	-2.1	2.0	1.6
Change in fecal boli incidents, locomotor task	0.5	0.5	1.6	0.3	0.7	0.8	-0.1	0.0	-1.3	0.3	0.8	1.0
Time >=10cm from walls, locomotor time 1	3.4	3.4	7.2	-1.7	-1.1	-1.5	1.9	2.0	0.3	-1.7	2.7	2.5
Bouts of movement, locomotor time 1	0.6	0.7	3.0	-0.5	-0.8	-1.0	0.6	0.4	1.7	-0.5	0.2	0.3
Total resting periods, locomotor time 1	0.4	0.5	2.2	-0.4	-0.7	-0.8	0.5	0.3	1.5	-0.4	0.2	0.3
Rest time, locomotor task time 1	2.1	2.3	4.1	-1.4	-1.2	-1.4	1.6	1.2	1.7	-1.4	2.0	1.5
Distance moved, locomotor task time 1	0.9	1.0	2.1	1.1	1.2	1.1	-1.0	-0.8	-1.4	0.9	-0.8	0.1
Vertical activity count, locomotor time 1	2.0	2.1	2.9	1.6	1.4	1.5	-1.6	-1.5	-1.3	1.3	-1.7	-1.0
Time >=10cm from walls, locomotor time 2	1.3	1.4	3.5	-1.0	-0.8	-0.9	1.4	1.9	-0.2	-0.9	1.7	0.7
Bouts of movement, locomotor time 2	0.1	0.1	0.4	-0.2	0.1	-0.2	0.3	-0.1	0.2	0.0	0.5	0.7
Total resting periods, locomotor time 2	0.2	0.2	0.7	-0.5	-0.2	-0.4	0.5	0.1	0.6	-0.2	0.8	0.8
Rest time, locomotor task time 2	3.1	3.6	4.3	-2.1	-2.1	-2.0	2.0	1.7	2.0	-2.0	2.0	0.9
Distance moved, locomotor task time 2	1.5	1.7	2.6	1.6	1.6	1.4	-1.3	-1.0	-1.6	1.3	-1.0	-0.7
Vertical activity count, locomotor time 2	1.8	1.9	3.2	1.8	1.6	1.5	-1.4	-1.1	-1.1	1.5	-1.2	-1.2
Light reinforcement 1	0.7	1.2	2.9	1.0	1.1	0.8	-1.4	-1.7	-0.5	1.0	-1.5	-0.2
Light reinforcement 2	1.1	1.4	2.3	-1.4	-1.3	-1.5	1.3	0.8	1.0	-1.4	0.7	1.0
Bone: marrow area	0.1	0.3	1.1	0.3	-0.1	0.3	-0.1	0.5	-1.0	0.1	-0.2	-1.1
Bone: maximum diameter	0.4	0.7	2.7	-0.3	-0.5	-0.3	0.8	1.6	-0.5	-0.6	1.0	-0.7
Bone: maximum force	0.1	0.1	0.3	-0.2	-0.3	-0.1	0.2	0.6	-0.1	-0.2	0.1	-0.6
Bone: maximum moment	0.0	0.1	0.2	-0.1	-0.2	-0.0	0.2	0.4	-0.3	-0.2	0.2	-0.4
Mean time between licks in bursts	0.4	0.6	2.4	-0.5	-0.7	-0.6	-0.3	-0.9	1.5	-0.2	-0.9	-0.5
Mean num. licks in bursts	3.5	4.2	5.4	2.3	2.2	2.2	-2.3	-2.0	-1.7	2.2	-1.9	-1.5
Cd content in liver	0.5	0.5	1.2	0.6	0.3	0.6	-0.6	-0.3	-1.0	0.6	-0.9	-1.1
Co content in liver	0.4	0.5	0.8	0.6	0.8	0.9	-0.8	-0.8	-0.4	0.8	-0.1	-0.5
Cu content in liver	0.5	0.6	1.0	1.0	1.0	0.9	-0.8	-0.7	-0.4	1.0	-0.4	0.5
Fe content in liver	1.7	2.0	3.8	1.5	1.5	1.5	-1.4	-0.8	-2.0	1.7	-1.3	-0.8
K content in liver	0.2	0.2	0.6	-0.1	-0.2	-0.1	-0.3	-0.4	0.2	-0.1	-0.7	0.8
Mg content in liver	0.0	0.0	0.1	-0.1	-0.2	0.1	-0.2	-0.1	0.3	-0.1	-0.1	0.4
Mn content in liver	0.1	0.1	0.2	-0.4	-0.5	-0.3	-0.0	-0.0	-0.4	-0.4	-0.3	-0.0
Na content in liver	0.0	0.0	0.1	0.2	-0.0	0.2	-0.2	0.1	-0.1	0.2	-0.3	0.3
Rb content in liver	0.7	0.9	2.1	0.8	0.9	0.7	-1.0	-1.4	0.1	1.1	-1.0	0.8
Se content in liver	0.7	0.8	1.6	-1.3	-1.0	-1.1	0.8	0.6	0.4	-1.1	0.8	0.8
Sr content in liver	1.2	1.1	3.2	-0.9	-1.0	-1.0	1.0	1.0	1.8	-0.8	0.9	-0.2
Zn content in liver	0.5	0.6	1.0	1.0	0.7	1.0	-0.8	-0.4	-0.2	1.0	-0.5	-0.7
Bone: minimum diameter	1.3	2.4	6.4	1.5	1.4	1.7	-1.4	-0.8	-2.5	1.4	-1.2	-1.5
Time in familiar zone, hab. session 1	3.7	3.5	4.9	2.0	2.2	2.2	-2.0	-2.0	-2.1	2.0	-1.1	0.4
Time in novel zone, hab. session 1	1.6	1.6	2.6	-1.2	-1.3	-1.3	1.4	1.4	1.6	-1.2	1.1	-0.5
Total zone transitions, hab. session 1	0.1	0.1	0.5	-0.1	-0.1	-0.1	0.5	0.7	-0.1	-0.2	0.6	-0.2
Total locomotion distance, hab. session 1	0.1	0.1	0.3	-0.3	-0.3	-0.3	0.5	0.5	0.4	-0.2	0.4	-0.3
Locomotion velocity, hab. session 1	0.2	0.3	0.7	-0.5	-0.6	-0.5	0.6	0.9	0.3	-0.4	0.3	-0.7
Time in familiar zone, hab. session 2	1.9	2.0	3.2	1.6	1.8	1.7	-1.4	-1.5	-1.5	1.5	-0.5	0.5
Time in novel zone, hab. session 2	2.0	1.9	2.6	-1.5	-1.6	-1.6	1.5	1.6	1.6	-1.4	0.9	-0.5
Total zone transitions, hab. session 2	0.0	0.0	0.1	-0.0	-0.1	-0.2	-0.0	0.0	-0.0	-0.3	-0.2	-0.1
Total locomotion distance, hab. session 2	0.7	0.9	1.6	-1.0	-1.2	-1.1	0.8	0.8	1.0	-1.3	0.7	0.7
Locomotion velocity, hab. session 2	0.4	0.5	1.2	-0.8	-1.0	-0.8	0.5	0.6	0.6	-1.1	0.3	0.6
Novel to familiar place preference ratio	0.4	0.4	1.2	-0.3	-0.3	-0.2	0.6	1.0	0.0	-0.3	0.9	-1.1
Novelty place preference	0.3	0.3	1.2	-0.1	-0.1	0.0	0.3	0.7	-0.2	-0.1	0.7	-1.1
Time in novel zone, NPP test	0.3	0.3	1.8	-0.0	0.0	0.1	0.3	0.8	-0.2	0.0	0.6	-1.3
Total zone transitions, NPP test	0.4	0.6	1.6	0.8	0.6	0.6	-0.9	-1.0	-0.4	0.6	-1.3	-0.4
Total locomotion distance, NPP test	0.1	0.2	0.4	-0.3	-0.6	-0.5	0.2	0.2	0.5	-0.5	-0.4	-0.5
Locomotion velocity, NPP test	0.1	0.1	0.6	0.2	-0.1	-0.0	-0.3	-0.3	-0.0	-0.1	-0.8	-0.4
Intraocular pressure	2.5	3.4	7.3	-1.8	-1.6	-1.6	2.0	1.9	1.4	-2.1	2.7	1.2
Delta distance traveled before/after self-admin	0.8	0.9	1.6	1.3	1.0	1.1	-1.0	-0.9	-0.4	1.1	-0.7	-0.5
Delta ambulatory time before/after self-admin	1.4	1.5	2.6	1.6	1.2	1.4	-1.3	-1.1	-0.7	1.4	-1.0	-1.0
Parametrial fat weight	0.5	1.0	3.9	0.7	0.6	0.6	-0.6	0.1	-1.1	1.0	-1.1	-2.0
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.5	0.4	0.6	-0.6	-0.8	0.1	0.3	-0.4	-0.5
Pavlov. Cond. magazine entry latency	2.1	2.7	4.8	1.8	1.5	1.5	-1.8	-1.5	-1.1	1.7	-2.2	-1.6
Pavlov. Cond. change in total contacts	2.8	3.0	4.2	2.0	1.7	1.7	-1.7	-1.1	-1.5	2.0	-1.9	-1.7
Pavlov. Cond. index score	0.1	0.2	0.7	0.4	0.3	0.1	-0.4	-0.2	-0.2	0.4	-0.8	-0.5
Pavlov. Cond. latency score	0.0	0.0	0.2	-0.0	-0.1	-0.2	0.1	0.3	-0.1	0.1	-0.4	-0.3
Pavlov. Cond. lever contacts	0.0	0.0	0.2	-0.1	0.1	-0.2	0.1	0.3	-0.5	0.1	-0.1	0.2
Pavlov. Cond. magazine entry number	1.5	1.9	3.1	-1.6	-1.3	-1.3	1.5	1.3	0.7	-1.5	1.8	1.2
Pavlov. Cond. intertrial magazine entries	1.5	1.9	2.4	-1.5	-1.4	-1.3	1.5	1.4	1.4	-1.4	1.5	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.9	0.5	0.4	0.2	-0.5	-0.4	-0.3	0.5	-1.0	-0.4
Pavlov. Cond. response bias	1.4	1.7	2.3	1.5	1.4	1.3	-1.3	-1.0	-1.3	1.5	-1.4	-0.8
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.1	-0.1	0.0	0.3	0.2	0.1	-0.1	0.5	-0.4
Pavlov. Cond. magazine entry latency	0.1	0.2	0.6	-0.0	0.1	-0.1	0.1	0.3	-0.7	-0.0	0.4	0.8
Pavlov. Cond. change in total contacts	0.5	0.6	1.9	0.5	0.6	0.5	-1.1	-1.4	-0.5	0.4	-1.1	0.5
Pavlov. Cond. index score	0.1	0.2	0.6	0.2	0.3	0.2	-0.5	-0.5	-0.5	0.2	-0.3	0.7
Pavlov. Cond. latency score	0.2	0.2	0.6	0.3	0.4	0.2	-0.5	-0.5	-0.6	0.3	-0.4	0.8
Pavlov. Cond. lever contacts	0.1	0.2	0.4	0.3	0.3	0.2	-0.5	-0.3	-0.7	0.3	-0.6	0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.6	-0.2	-0.2	-0.1	0.3	0.3	0.3	-0.0	0.0	-0.8
Pavlov. Cond. intertrial magazine entries	1.7	2.2	3.5	1.5	1.5	1.5	-1.7	-1.9	-0.9	1.4	-1.6	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.5	0.2	0.3	0.2	-0.5	-0.5	-0.5	0.2	-0.4	0.7
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.0	0.0	-0.0	-0.2	-0.2	-0.5	-0.1	-0.2	0.6
Time in closed arm before self-admin	0.7	0.8	2.1	0.7	0.3	0.6	-0.9	-0.6	-0.8	0.6	-1.4	-1.4
Time in closed arm after self-admin	0.9	1.0	1.9	-1.0	-1.2	-1.2	0.8	0.6	1.4	-1.0	0.6	0.7
Time in open arm before self-admin	0.2	0.3	0.7	-0.4	-0.2	-0.5	0.5	0.4	0.5	-0.2	0.7	0.9
Time in open arm after self-admin	0.1	0.1	0.5	-0.2	0.1	-0.1	0.3	0.3	-0.3	-0.3	0.7	0.4
Bone: periosteal estimation	0.2	0.5	2.1	0.6	0.3	0.6	-0.2	0.6	-1.4	0.4	-0.1	-1.1
Bone: periosteal perimeter	0.2	0.3	0.8	0.4	0.3	0.5	-0.1	0.5	-0.9	0.2	0.2	-0.8
Bone: post-yield work	0.1	0.1	0.3	-0.4	-0.4	-0.4	0.4	0.5	0.2	-0.4	0.2	-0.3
Progressive ratio test 1 active lever presses	0.8	0.9	2.7	1.2	1.1	1.1	-0.8	-0.3	-1.7	0.6	-0.2	0.4
Progressive ratio test 1 breakpoint	0.5	0.6	2.0	0.9	0.8	0.8	-0.6	-0.2	-1.4	0.4	-0.2	0.5
Progressive ratio test 1 inactive lever presses	0.5	0.6	1.7	0.7	0.8	0.9	-0.7	-0.6	-1.3	0.2	-0.3	0.7
Progressive ratio test 2 active lever presses	0.6	0.6	1.2	0.9	1.0	0.8	-0.1	0.3	-1.1	0.5	0.8	0.9
Progressive ratio test 2 breakpoint	0.6	0.7	1.3	0.9	1.0	0.8	-0.1	0.4	-1.1	0.6	0.8	0.9
Progressive ratio test 2 inactive lever presses	1.3	1.5	3.0	1.7	1.7	1.7	-1.0	-0.7	-1.5	1.1	-0.0	-0.1
Incentive Sensitization - Responses	0.4	0.5	1.0	0.8	1.0	0.7	-0.2	0.2	-0.7	1.0	0.2	0.6
Incentive Sensitization - Breakpoint	0.5	0.5	1.0	0.8	1.0	0.7	-0.2	0.3	-0.8	1.0	0.2	0.5
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.0	-0.8	-0.9	-0.8	0.3	-0.1	1.0	-0.6	-0.3	-0.4
Progressive ratio	0.2	0.2	0.7	-0.3	-0.5	-0.5	0.3	0.1	0.8	-0.4	-0.0	0.4
Food seeking constrained by brief footshock	3.6	4.4	6.7	2.5	2.5	2.2	-2.3	-2.6	-1.2	2.3	-1.7	-0.2
Seeking ratio, punishment vs. effort	2.2	2.7	3.3	1.8	1.8	1.8	-1.8	-1.8	-1.3	1.8	-1.4	-1.3
Retroperitoneal fat weight	0.1	0.4	1.0	0.6	0.6	0.4	0.2	1.0	-0.9	0.6	0.7	-0.3
Reaction time number correct	7.5	10.9	14.4	3.8	3.7	3.6	-3.5	-3.3	-3.3	3.7	-3.0	-0.3
Reaction time mean minus median	0.2	0.3	1.0	-0.3	-0.4	-0.8	0.4	0.2	1.0	-0.4	-0.3	0.6
Reaction time mean minus median AUC	0.0	0.1	0.2	0.2	0.1	-0.1	-0.0	-0.2	0.3	0.1	-0.4	0.3
Reaction time num false alarms	0.5	0.7	1.7	-0.8	-0.6	-0.7	1.0	1.3	0.3	-0.8	1.1	-0.1
Reaction time num false alarms AUC	0.9	1.3	2.8	-1.1	-0.9	-1.0	1.3	1.7	0.6	-1.1	1.6	0.2
Reaction time trials correct on left	7.5	10.9	14.4	3.8	3.7	3.6	-3.5	-3.3	-3.3	3.7	-3.0	-0.3
Reaction time trials on left	7.8	11.2	14.9	3.9	3.8	3.6	-3.6	-3.4	-3.3	3.7	-3.1	-0.3
Reaction time mean	1.2	1.6	4.6	-1.3	-1.3	-1.6	1.2	0.8	2.2	-1.2	0.7	0.3
Reaction time mean AUC	0.8	1.1	4.1	-1.0	-1.0	-1.3	1.0	0.5	2.0	-0.8	0.5	0.0
Median of all reaction times	1.4	1.9	5.5	-1.5	-1.5	-1.7	1.3	0.8	2.3	-1.2	0.9	0.0
Reaction time omissions	1.1	1.5	2.4	1.5	1.4	1.0	-1.2	-1.4	-0.3	1.4	-1.4	-0.4
Reaction time false alarm rate	5.4	7.5	9.9	-3.0	-2.8	-2.9	3.1	3.1	2.3	-3.0	2.9	0.4
Reaction time premature initiation rate	0.8	1.1	1.9	1.1	1.0	1.0	-1.2	-1.1	-0.9	1.0	-1.4	-0.1
Reaction time premature initiations	5.3	7.5	10.0	3.2	3.0	2.9	-3.0	-2.8	-2.7	3.0	-2.8	-0.2
Std. dev. reaction times	0.2	0.3	1.0	-0.4	-0.5	-0.7	0.6	0.4	1.0	-0.5	0.1	0.3
Reaction time trials completed	7.8	11.2	14.9	3.9	3.8	3.6	-3.6	-3.4	-3.3	3.7	-3.1	-0.3
Reaction time trials AUC	7.0	10.1	13.4	3.7	3.6	3.4	-3.4	-3.1	-3.2	3.6	-2.9	-0.3
Run reversals in cocaine runway, females	0.6	0.5	1.3	-0.7	-0.6	-0.9	0.6	0.7	1.1	-0.6	0.5	0.7
Run reversals in cocaine runway, males	0.3	0.2	0.6	-0.6	-0.4	-0.4	0.6	0.5	0.1	-0.6	0.8	0.3
Latency to leave start box in cocaine runway	1.5	1.6	4.9	-1.2	-1.4	-1.3	1.1	0.9	2.2	-1.2	0.9	-0.1
Latency to leave start box in cocaine runway, F	0.8	0.9	1.9	-0.9	-0.9	-1.0	0.9	0.8	1.4	-0.8	0.9	0.8
Latency to leave start box in cocaine runway, M	0.9	0.9	3.5	-0.7	-0.9	-0.9	0.7	0.3	1.9	-0.9	0.5	-0.7
Std. dev. time between licks in bursts	2.3	2.7	4.3	-2.1	-2.0	-2.0	1.3	0.8	1.8	-1.8	0.9	1.5
Total sessions with >9 infusions	0.3	0.3	1.8	0.4	0.5	0.6	-0.3	-0.1	-1.3	0.0	0.0	0.5
Short access day 1 total inactive lever presses	1.1	1.3	2.7	1.1	1.2	1.5	-1.1	-1.1	-1.6	0.9	-0.3	-0.0
Short access day 10 total inactive lever presses	2.0	2.2	3.2	-1.8	-1.7	-1.7	1.3	0.8	1.6	-1.7	0.9	1.4
Short access day 1 total infusions	0.9	1.0	2.7	0.9	1.1	1.0	-1.0	-0.9	-1.6	0.8	-0.7	0.4
Short access day 10 total infusions	2.0	2.2	4.2	1.8	1.6	2.0	-1.6	-1.2	-2.1	1.3	-0.8	-0.3
Short access total infusions	1.2	1.4	3.4	1.3	1.4	1.3	-1.1	-1.0	-1.8	0.7	-0.4	1.0
Short access day 1 locomotion	0.1	0.1	0.2	-0.1	-0.1	-0.0	-0.2	-0.4	-0.3	-0.3	-0.2	0.4
Short access day 10 total locomotion	0.1	0.1	0.2	-0.3	-0.5	-0.2	-0.0	0.0	0.1	-0.4	-0.2	-0.5
Short access total locomotion	0.3	0.4	1.2	0.2	0.2	0.3	-0.7	-1.1	-0.6	0.0	-0.7	0.7
One hour access (0.3 mA shock)	1.0	1.2	2.9	1.3	1.4	1.2	-0.9	-0.5	-1.7	1.0	-0.4	0.4
Compulsive drug intake	1.5	1.5	2.2	-1.3	-1.2	-1.5	1.2	1.0	1.2	-1.4	0.8	1.3
One hour access (shock baseline)	3.8	4.4	6.8	2.5	2.4	2.5	-2.1	-1.6	-2.6	2.3	-1.4	-0.9
Social response proportion	1.2	1.3	2.9	-1.2	-1.0	-1.3	1.2	0.9	1.0	-0.9	0.9	1.7
Social responses	0.3	0.4	2.6	-0.4	-0.0	-0.4	0.3	-0.2	0.5	-0.1	0.2	1.6
Social time	0.2	0.2	0.8	0.0	0.1	0.1	-0.4	-0.7	-0.1	0.2	-0.9	-0.8
Soleus weight	0.2	0.5	0.8	-0.7	-0.7	-0.6	0.6	0.9	-0.7	-0.8	0.2	-0.6
Bone: stiffness	0.1	0.1	0.8	0.2	-0.1	0.1	-0.1	0.3	-0.3	0.1	-0.3	-0.9
Tibialis anterior weight	1.5	5.2	9.1	-2.2	-2.1	-2.1	2.8	2.9	1.5	-2.2	3.0	1.1
Time to tail flick, vehicle, before self-admin	2.7	2.8	8.6	1.6	1.7	1.4	-2.0	-2.9	-0.3	1.4	-1.7	0.4
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.5	0.6	0.6	0.6	-0.5	-0.6	-0.1	0.7	-0.6	-0.6
Time to tail flick, test, before self-admin	0.3	0.3	0.7	0.8	0.6	0.5	-0.6	-0.2	-0.4	0.6	-0.7	-0.2
Time to tail flick, test, after self-admin	0.0	0.0	0.2	0.2	0.3	0.2	0.1	0.1	-0.0	0.5	0.2	-0.1
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	4.1	-1.1	-1.3	-1.0	1.4	2.0	0.7	-1.0	0.7	-1.3
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.3	0.1	0.1	0.1	0.3	0.0
Tibia length	5.0	14.0	20.2	3.9	3.2	3.8	-4.1	-3.5	-3.8	3.6	-4.5	-3.1
Ambulatory time before self-admin	0.7	0.7	5.5	-0.6	0.0	-0.4	0.3	-0.2	-0.1	0.1	0.5	2.4
Ambulatory time after self-admin	0.8	0.8	2.3	0.7	1.0	0.7	-0.7	-1.0	-0.5	1.1	-0.3	1.5
Bone: tissue strength	1.9	1.8	3.5	-1.5	-1.6	-1.6	1.2	0.8	1.9	-1.4	1.0	0.8
Total heroin consumption	0.3	0.3	1.1	-0.5	-0.6	-0.7	0.4	-0.1	1.1	-0.4	0.2	-0.2
Bone: trabecular number	0.4	0.6	1.1	0.7	0.7	0.8	-0.1	1.0	-1.0	1.0	0.2	-1.0
Bone: trabecular spacing	0.2	0.2	0.8	-0.1	0.1	-0.1	-0.2	-0.9	0.1	-0.5	-0.0	0.8
Bone: trabecular thickness	1.2	1.4	5.2	-0.8	-1.1	-0.7	1.1	2.3	-0.0	-0.6	0.7	-1.7
Bone: trabecular tissue density	1.8	2.5	4.3	-1.7	-2.0	-1.8	1.4	1.1	2.1	-1.9	1.1	0.4
Water consumed over 24 hours	2.1	2.5	3.3	-1.5	-1.5	-1.6	1.6	1.8	1.0	-1.6	1.7	1.8
Number of responses in last shaping day	0.4	0.4	1.3	-0.1	-0.1	0.1	0.5	1.1	-1.1	-0.5	0.7	-0.1