LOC120100677

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	intron excision ratio	chr2_30467590_30469768	0.03	0.02	8.2e-05	0.03	0.01	0.03	0.03	2.2e-05	1.8e-03	1.6e-05	2.1e-05
2	PL	intron excision ratio	chr2_30467590_30478990	0.02	0.01	4.1e-03	0.03	0.02	0.02	0.02	2.5e-04	5.7e-03	2.8e-03	1.9e-03
3	NAcc	intron excision ratio	chr2_30467590_30478990	0.08	0.04	1.2e-12	0.08	0.06	0.07	0.07	1.0e-11	6.5e-10	3.7e-11	5.4e-11
4	NAcc	gene expression	LOC120100677	0.2	0.07	0.0e+00	0.32	0.26	0.31	0.31	3.2e-49	2.0e-39	1.8e-47	4.1e-48
5	Liver	gene expression	LOC120100677	0.25	0.09	0.0e+00	0.16	0.18	0.18	0.18	4.2e-17	4.0e-20	6.5e-20	3.7e-20
6	pVTA	gene expression	LOC120100677	0.11	0.07	5.9e-07	0.04	0.06	0.07	0.09	3.4e-04	9.8e-06	4.7e-06	2.0e-07
7	Brain	gene expression	LOC120100677	0.22	0.11	5.8e-15	0.15	0.14	0.16	0.16	1.2e-13	1.2e-12	2.0e-14	1.7e-14
8	BLA	gene expression	LOC120100677	0.11	0.07	4.4e-03	0	0.02	0	0.01	2.8e-01	2.1e-02	2.2e-01	6.3e-02
9	IL	gene expression	LOC120100677	0.28	0.13	2.3e-03	0.13	0.08	0.06	0.18	4.2e-04	5.6e-03	1.3e-02	3.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.1	0.1	0.3	-0.5	0.4	0.3	0.1	-0.3	-0.1	-0.1	0.0	0.3
Area under the delay curve	0.8	0.9	2.4	1.2	-1.5	-0.9	1.0	1.2	0.5	0.8	0.5	0.1
BMI with tail	1.0	3.4	5.8	2.4	-2.3	-2.0	1.9	2.2	1.8	1.6	0.2	-0.9
BMI without tail	1.2	3.7	6.5	2.5	-1.8	-2.1	2.3	2.0	2.4	1.9	1.0	-0.2
Body weight	2.0	8.9	13.1	3.6	-3.3	-3.0	3.2	2.9	3.3	3.2	2.3	1.2
Weight adjusted by age	1.3	1.9	9.1	-0.2	0.2	0.4	-0.7	-0.0	-0.6	-1.2	-2.4	-3.0
Bone surface	0.1	0.2	0.5	0.2	-0.6	-0.2	0.7	0.6	0.3	0.4	0.1	0.0
Bone volume	0.1	0.2	0.5	-0.7	0.6	0.4	0.0	-0.5	-0.4	-0.2	-0.2	0.3
Breakpoint value in progressive ratio session	0.0	0.1	0.2	-0.1	-0.3	0.2	-0.2	-0.1	-0.5	-0.1	0.1	0.3
Number of licking bursts	0.3	0.5	1.6	0.8	0.3	-0.0	-0.2	-0.6	1.1	-0.0	1.3	0.6
Context. condit. distance diff. score	1.0	1.2	2.1	-0.9	1.4	1.2	-1.3	-1.4	-0.8	-1.2	-0.8	-0.5
Locomotion velocity, session 1	0.5	0.5	1.7	0.0	1.0	0.3	-0.1	-0.8	0.5	-0.2	1.1	1.3
Locomotion distance, session 1	0.5	0.7	1.5	-0.4	1.1	0.7	-0.8	-1.2	-0.2	-0.6	0.8	1.1
Locomotion velocity, session 2	0.8	0.9	3.2	0.2	1.0	-0.4	0.6	-0.3	1.1	0.7	1.3	1.8
Locomotion distance, session 2	1.0	1.4	3.7	-0.7	1.7	1.2	-1.0	-1.9	-0.3	-1.1	0.9	1.1
Locomotion velocity, session 3	0.3	0.3	0.8	0.5	0.6	0.4	-0.6	-0.9	0.1	-0.9	0.4	-0.3
Locomotion distance, session 3	0.3	0.3	1.0	-0.0	0.5	0.5	-0.8	-0.8	-0.4	-1.0	0.1	-0.5
Stereotopy head waving bouts, day 3	0.6	0.7	1.5	-0.5	0.4	1.0	-0.9	-1.0	-0.7	-0.7	0.9	1.2
Stereotopy head waving duration, day 3	0.3	0.4	1.5	0.1	-0.8	-0.1	0.3	0.5	0.0	0.7	0.8	1.2
Locomotion velocity, session 7	0.9	0.9	1.8	-0.6	1.3	0.8	-0.8	-0.7	-0.5	-1.1	-1.3	-1.2
Locomotion distance, session 7	0.1	0.1	0.4	0.3	0.5	-0.3	0.4	-0.2	0.6	0.2	0.2	0.1
Stereotopy head waving bouts, day 7	1.0	1.2	2.8	-0.2	0.8	1.4	-1.7	-1.3	-0.6	-1.6	-0.3	-0.5
Stereotopy head waving duration, day 7	0.2	0.3	0.7	0.0	0.1	0.7	-0.9	-0.4	-0.2	-0.7	-0.4	-0.4
Locomotion velocity, session 8	2.3	2.7	7.3	-1.5	2.7	1.7	-1.6	-2.4	-0.7	-1.4	-0.6	0.9
Locomotion distance, session 8	0.8	1.2	3.1	-0.4	1.8	1.1	-1.2	-1.7	-0.3	-1.3	-0.4	-0.3
Degree of sensitization distance	0.2	0.2	0.7	-0.2	0.4	-0.2	0.6	-0.1	0.6	0.7	0.2	0.9
Degree of sensitization stereotypy	1.1	1.2	2.7	-0.2	0.7	1.2	-1.4	-0.9	-0.6	-1.6	-1.0	-1.5
Conditioned locomotion	0.2	0.3	0.8	-0.1	-0.6	0.3	-0.3	0.3	-0.9	-0.4	-0.7	-0.5
Cocaine response after cond. corrected	0.5	0.6	1.3	0.9	-0.4	-0.9	1.0	0.6	1.2	0.8	0.4	-0.2
Cocaine response after cond. not corrected	0.7	0.8	2.2	1.0	-0.3	-1.0	1.2	0.6	1.5	1.0	0.5	-0.0
Cocaine response before conditioning	0.1	0.1	0.3	-0.2	0.5	0.2	-0.2	-0.4	-0.0	-0.3	-0.2	-0.3
Saline control response	0.3	0.4	1.2	0.3	-0.5	-0.6	0.4	0.7	0.3	0.4	-1.1	-0.9
Bone: connectivity density	0.1	0.1	0.6	0.3	-0.7	-0.1	0.2	0.5	0.1	0.2	0.4	0.0
Bone: cortical apparent density	2.6	3.5	5.9	-1.5	1.8	2.1	-2.1	-1.8	-1.8	-2.4	-1.6	-1.5
Bone: cortical area	2.6	3.9	10.2	-2.6	0.6	1.8	-1.3	-0.3	-2.8	-1.4	-3.2	-1.8
Bone: cortical porosity	0.1	0.1	0.2	0.4	-0.3	0.1	-0.1	-0.4	0.1	-0.1	0.4	0.4
Bone: cortical porosity	0.3	0.3	0.7	-0.3	0.3	0.7	-0.7	-0.9	-0.5	-0.7	-0.2	0.2
Bone: cortical thickness	4.0	6.7	13.9	-2.8	1.3	2.7	-2.3	-1.2	-3.3	-2.5	-3.7	-2.3
Bone: cortical thickness	0.5	0.6	2.8	-0.3	0.0	-0.2	0.4	0.6	-0.4	0.0	-1.7	-1.2
Bone: cortical tissue density	2.2	3.1	5.3	-1.4	1.7	2.0	-2.0	-1.8	-1.7	-2.3	-1.3	-1.3
Condit. Reinf. active minus inactive responses	0.4	0.4	2.2	0.4	0.6	0.2	-0.1	-0.2	0.4	-0.5	-1.0	-1.5
Condit. Reinf. active-inactive response ratio	0.8	0.9	4.6	0.0	0.3	0.4	-0.2	0.1	-0.2	-0.7	-1.7	-2.2
Condit. Reinf. active responses	0.3	0.3	0.9	0.7	0.7	-0.2	0.2	-0.2	1.0	-0.1	-0.3	-0.9
Condit. Reinf. inactive responses	0.4	0.5	1.2	0.7	0.2	-0.7	0.6	0.1	1.1	0.7	0.7	0.7
Incentive salience index mean	0.4	0.5	1.8	1.2	0.1	-0.7	0.7	0.3	1.3	0.4	0.2	-0.5
Condit. Reinf. lever presses	0.5	0.7	1.9	1.0	-0.1	-0.7	0.7	0.1	1.4	0.6	1.3	0.7
Condit. Reinf. active minus inactive responses	0.8	1.1	3.1	-0.6	1.3	0.5	-0.5	-0.7	-0.3	-1.0	-1.5	-1.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.0	0.4	0.1	-0.0	-0.4	0.2	-0.2	-0.4	-0.5
Condit. Reinf. active responses	1.0	1.4	3.6	-0.7	1.4	0.8	-0.8	-0.9	-0.5	-1.3	-1.6	-1.9
Condit. Reinf. inactive responses	0.2	0.2	1.1	0.4	-0.0	-0.3	0.3	0.5	0.3	-0.0	-0.6	-1.1
Condit. Reinf. lever presses	0.3	0.5	1.1	-0.5	1.1	0.3	-0.4	-0.7	-0.1	-0.6	-0.9	-0.9
Condit. Reinf. lever reinforcers received	0.8	1.1	3.1	-0.5	1.2	0.7	-0.7	-0.8	-0.4	-1.1	-1.5	-1.8
Conditioned reinforcement - actives	0.4	0.7	2.0	0.6	-1.4	-0.8	0.7	1.2	0.2	0.8	-0.5	-0.1
Conditioned reinforcement - inactives	0.2	0.3	0.7	-0.8	0.4	0.6	-0.4	-0.3	-0.7	-0.5	-0.8	-0.2
Conditioned locomotion	0.4	0.5	1.5	-0.5	-0.5	0.7	-0.7	-0.2	-1.1	-0.7	-1.2	-0.3
Patch foraging indifference point 0 sec	1.2	2.3	3.8	1.6	-1.0	-2.0	1.7	1.5	2.0	1.8	0.9	0.2
Patch foraging indifference point AUC	0.6	0.9	1.7	1.0	-1.2	-0.9	0.8	0.7	0.6	1.0	1.3	1.0
Delay disc. indifference point, 0s delay	0.6	0.7	1.7	-0.7	1.3	0.5	-0.4	-0.7	-0.2	-0.8	-0.9	-1.1
Delay disc. indifference point, 16s delay	0.5	0.6	3.2	0.7	-1.8	-0.3	0.4	1.1	-0.4	0.3	-0.1	-0.1
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	0.6	-0.4	-0.1	0.1	0.1	0.4	-0.1	-0.4	-0.5
Delay disc. indifference point, 24s delay	3.1	3.5	4.7	2.1	-1.7	-2.1	2.1	1.9	2.2	1.8	1.7	0.6
Delay disc. indifference point, 4s delay	0.4	0.4	1.6	0.2	0.4	-0.6	0.7	-0.0	0.7	0.6	1.2	0.7
Delay disc. indifference point, 8s delay	1.9	2.2	4.3	1.9	-2.1	-1.6	1.6	1.7	1.2	1.4	0.8	0.4
Indifference point function ln k	0.1	0.1	0.5	-0.2	0.2	0.0	0.0	0.0	-0.1	-0.2	-0.7	-0.4
Indifference point function log k	0.1	0.1	0.5	-0.2	0.2	0.0	0.0	0.0	-0.1	-0.2	-0.7	-0.4
Patch foraging total patch changes 0 sec	1.3	2.4	4.1	1.7	-1.1	-2.0	1.7	1.5	2.0	1.9	1.1	0.2
Patch foraging total patch changes 12 sec	1.2	1.6	2.4	1.6	-1.3	-1.4	1.3	1.2	1.4	1.4	0.9	0.0
Patch foraging total patch changes 18 sec	0.2	0.4	0.7	0.9	-0.5	-0.8	0.5	0.7	0.7	0.6	0.1	-0.3
Patch foraging total patch changes 24 sec	0.9	1.5	2.6	1.4	-1.6	-1.4	1.3	1.5	1.0	1.2	0.3	-0.6
Patch foraging total patch changes 6 sec	2.2	3.3	5.3	2.0	-1.4	-2.1	1.9	1.6	2.3	2.1	1.8	0.6
Patch foraging time to switch 0 sec	0.2	0.3	1.3	-0.3	0.5	0.5	-0.2	-0.1	-0.2	-0.5	-1.2	-0.8
Patch foraging water rate 0 sec	0.3	0.6	1.5	0.6	-0.6	-0.8	0.4	0.4	0.6	0.8	1.2	0.9
Patch foraging water rate 12 sec	0.7	1.4	2.4	-0.5	0.7	1.3	-1.3	-1.2	-1.0	-1.5	-1.5	-1.1
Patch foraging water rate 18 sec	0.2	0.2	1.1	0.4	-0.5	0.0	0.1	0.4	-0.1	-0.2	-0.7	-1.1
Patch foraging water rate 24 sec	0.8	1.2	1.8	1.3	-1.3	-1.3	1.2	1.1	1.1	1.1	0.4	0.2
Patch foraging water rate 6 sec	0.6	0.9	1.7	-1.2	0.8	0.9	-1.3	-1.0	-1.1	-0.8	-0.1	0.9
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.3	1.1	-0.3	-0.6	0.6	0.1	1.2	0.4	1.0	0.6
Distance traveled before self-admin	0.2	0.3	0.9	0.9	-1.0	-0.1	0.1	0.3	0.2	0.2	0.7	0.1
Distance traveled after self-admin	2.0	2.5	4.1	2.0	-1.3	-1.8	1.8	1.3	1.9	1.7	1.4	0.4
Extensor digitorum longus weight	0.1	0.2	0.4	0.2	-0.6	-0.1	0.4	0.3	0.4	0.5	0.6	0.7
Bone: elastic displacement	1.4	1.6	2.8	-1.2	0.6	1.6	-1.6	-1.7	-1.5	-1.2	0.4	1.0
Bone: elastic work	0.6	0.7	1.3	-1.0	0.0	1.1	-0.8	-0.9	-1.1	-0.4	0.4	1.1
Bone: endosteal estimation	0.3	0.7	1.8	0.5	-0.5	-1.0	1.3	0.9	0.8	1.2	0.3	0.2
Bone: endosteal perimeter	0.1	0.2	0.5	-0.3	-0.1	-0.4	0.6	0.6	-0.1	0.5	-0.7	-0.7
Epididymis fat weight	1.3	4.5	9.5	3.1	-2.3	-2.1	2.2	2.1	2.8	2.0	0.9	-0.3
Delta time in closed arm before/after self-admin	1.0	1.0	2.8	-0.7	-0.1	1.2	-1.3	-0.7	-1.7	-1.2	-0.5	-0.3
Delta time in open arm before/after self-admin	0.8	0.8	3.5	-0.0	0.7	-0.0	0.1	0.2	0.4	-0.3	-1.7	-1.9
Diff in mean of infusions in LGA sessions	0.5	0.6	2.0	-1.1	0.1	0.9	-0.8	-0.5	-1.4	-0.5	-0.1	0.5
Delay discount exponential model param	1.0	1.1	2.5	-1.3	1.6	1.0	-1.1	-1.2	-0.7	-0.9	-0.7	-0.2
Extinction: sum of active levers before priming	0.1	0.2	0.6	0.4	-0.1	0.1	-0.2	-0.1	0.3	-0.4	-0.5	-0.8
Active lever presses in extinction session 6	0.5	0.5	2.3	0.8	-1.5	-0.2	0.3	0.8	-0.4	0.1	0.6	0.3
Bone: final force	0.7	1.0	2.9	-1.5	0.7	0.9	-0.5	-0.4	-1.1	-0.5	-1.7	-0.9
Bone: final moment	0.5	0.7	2.2	-1.3	0.5	0.9	-0.4	-0.2	-0.9	-0.3	-1.5	-0.8
Food consumed during 24 hour testing period	1.0	1.4	9.1	0.9	0.1	-0.2	0.4	0.5	0.6	-0.4	-1.4	-3.0
Glucose	2.2	3.5	6.4	-2.1	2.5	1.8	-1.9	-2.0	-1.5	-2.0	-1.7	-1.0
Heart weight	1.1	1.7	4.5	2.1	-1.7	-1.1	1.2	1.3	1.6	1.0	-0.1	-0.3
Delay discount hyperbolic model param	0.8	0.9	1.8	-1.2	1.3	0.9	-1.0	-1.1	-0.7	-0.8	-0.7	-0.2
Intermittent access intake day 1-15 change	0.4	0.9	1.4	-1.1	1.2	1.1	-1.0	-1.0	-0.7	-0.9	-0.8	0.1
Intermittent access intake escalation	0.5	1.0	1.8	-1.3	1.3	1.2	-1.1	-1.1	-0.7	-1.0	-0.9	0.1
Intermittent access intake escalation 2	0.6	0.7	1.5	-1.2	0.6	0.9	-0.8	-0.5	-1.0	-0.7	-0.9	-0.1
Intermitt. access day 1 inactive lever presses	1.0	3.8	5.8	-2.3	1.6	2.3	-2.2	-1.8	-2.4	-2.1	-1.5	-0.4
Intermitt. access day 15 inactive lever presses	1.5	3.1	4.8	-1.5	2.2	2.2	-2.2	-2.1	-1.4	-2.1	-0.1	-0.2
Intermitt. access escalation Index	0.5	0.7	2.5	-1.2	1.6	0.6	-0.6	-1.0	-0.6	-0.7	0.6	0.0
Intermittent access day 1 total infusions	1.6	2.6	6.4	2.5	-2.3	-1.3	1.3	1.8	1.6	1.3	0.9	0.1
Intermittent access day 15 total infusions	0.1	0.1	0.5	0.5	0.0	0.2	-0.1	0.1	0.5	-0.2	-0.7	-0.4
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.4	0.6	-0.4	0.4	-0.3	0.0	0.2	-0.3	-0.7	-0.2
Intermittent access total infusions	0.4	0.5	1.8	1.3	-0.9	-0.4	0.4	0.8	0.8	0.3	-0.3	-0.3
Intermittent access day 1 locomotion	0.8	1.0	3.5	1.5	-1.9	-0.6	0.6	1.0	0.6	0.8	-0.2	0.3
Intermittent access day 15 total locomotion	0.7	1.3	4.5	1.6	-2.1	-0.5	0.6	1.3	0.8	0.8	-1.1	-0.4
Intermittent access total locomotion	0.5	0.6	2.7	1.2	-1.6	0.0	-0.0	0.5	0.2	0.2	-0.7	0.0
Intermittent access standard deviation	0.2	0.3	0.7	0.6	-0.4	0.7	-0.7	-0.4	-0.1	-0.8	-0.5	-0.6
Left kidney weight	4.7	21.9	36.0	6.0	-5.4	-5.0	5.1	5.2	5.1	4.8	2.3	0.7
Right kidney weight	4.4	19.9	33.0	5.7	-5.2	-4.9	4.8	5.0	4.8	4.6	1.8	0.1
Cocaine induced anxiety	0.1	0.2	0.9	0.2	-1.0	-0.2	0.1	0.7	-0.4	0.0	-0.1	-0.2
Post-drug Anxiety	0.8	0.8	3.0	1.2	-1.7	-0.7	0.7	1.3	0.2	0.5	0.1	-0.2
Baseline Anxiety	0.4	0.4	1.5	1.2	-0.3	-0.2	0.4	-0.1	1.0	0.3	0.6	0.7
Tail length	1.3	5.2	7.9	2.3	-1.5	-2.4	2.7	1.8	2.8	2.7	2.2	1.8
Length with tail	1.8	8.0	11.5	2.8	-2.6	-2.9	3.0	2.5	3.1	3.4	2.7	2.5
Length without tail	1.2	3.7	5.4	1.9	-2.0	-2.1	2.0	2.0	2.0	2.3	1.4	1.4
Times rat made contact with spout	1.5	1.7	5.4	1.8	-1.0	-1.1	1.1	1.1	1.2	0.3	-0.7	-2.3
Lifetime Intake	0.6	0.7	2.7	1.6	-1.2	-0.5	0.5	0.8	0.9	0.4	0.2	0.2
Liver weight, left	2.5	4.1	6.6	2.4	-1.7	-2.4	2.6	2.3	2.3	2.0	-0.0	-0.7
Liver weight, right	2.2	3.8	5.4	2.3	-1.9	-2.2	2.3	2.1	2.2	2.0	1.1	0.8
Locomotor activity	0.2	0.3	1.2	0.7	0.1	-0.0	-0.3	-0.0	0.6	-0.5	-0.4	-1.1
Locomotor testing distance	0.9	1.6	6.8	1.1	-0.7	-0.9	0.7	1.3	0.7	0.0	-1.5	-2.6
Locomotor testing rearing	0.8	1.7	7.7	0.7	-0.8	-0.8	0.5	1.2	0.2	-0.2	-2.0	-2.8
Locomotion in novel chamber	0.4	0.5	1.1	0.2	-0.0	0.8	-0.8	-0.8	-0.6	-1.1	-0.7	-0.8
Locomotion in novel chamber post-restriction	1.2	1.9	7.0	0.8	-0.1	-0.7	1.0	-0.2	1.3	1.0	2.7	2.3
Fecal boli incidents, locomotor time 1	0.1	0.2	0.7	-0.2	-0.4	0.5	-0.4	0.1	-0.3	0.1	0.8	0.8
Change in fecal boli incidents, locomotor task	0.1	0.1	0.6	0.1	0.3	-0.1	0.1	-0.4	0.2	-0.1	0.3	0.8
Time >=10cm from walls, locomotor time 1	0.9	0.9	2.1	-0.9	-0.6	1.0	-0.9	-0.6	-1.3	-0.5	1.0	1.4
Bouts of movement, locomotor time 1	0.3	0.3	0.9	-0.6	0.9	-0.3	0.4	0.4	0.2	0.4	-0.9	-0.5
Total resting periods, locomotor time 1	0.3	0.3	0.6	-0.6	0.8	-0.5	0.6	0.5	0.4	0.6	-0.6	-0.2
Rest time, locomotor task time 1	0.4	0.5	1.6	0.0	1.2	0.6	-0.5	-1.2	0.3	-0.4	0.2	0.6
Distance moved, locomotor task time 1	0.5	0.8	2.0	0.5	-1.1	-0.9	0.8	1.4	0.0	0.4	-0.7	-1.2
Vertical activity count, locomotor time 1	0.4	0.9	2.3	-0.1	-0.8	-0.7	0.7	1.5	-0.7	0.2	-1.2	-1.3
Time >=10cm from walls, locomotor time 2	0.2	0.4	1.3	0.7	-0.8	-0.4	0.4	0.1	0.4	0.4	1.1	0.4
Bouts of movement, locomotor time 2	0.1	0.1	0.7	0.2	-0.1	0.0	0.1	-0.0	-0.0	-0.0	0.8	0.1
Total resting periods, locomotor time 2	0.0	0.1	0.4	0.1	0.2	0.3	-0.2	-0.3	-0.0	-0.2	0.7	0.0
Rest time, locomotor task time 2	1.7	2.1	3.1	-1.0	1.4	1.7	-1.5	-1.3	-1.0	-1.8	-1.7	-1.6
Distance moved, locomotor task time 2	0.9	1.1	1.9	1.3	-1.2	-1.4	1.2	1.3	0.5	0.8	-0.3	-0.8
Vertical activity count, locomotor time 2	0.4	0.5	1.0	1.0	-0.6	-0.9	0.9	0.9	0.3	0.4	-0.7	-0.8
Light reinforcement 1	0.8	1.9	3.2	1.3	-1.5	-1.8	1.6	1.6	1.2	1.5	0.4	-0.4
Light reinforcement 2	0.4	0.6	2.5	0.9	-1.6	-0.2	0.4	0.7	0.1	0.4	1.1	0.5
Bone: marrow area	0.3	0.7	1.7	0.5	-0.5	-1.0	1.3	0.9	0.9	1.2	0.4	0.3
Bone: maximum diameter	0.4	0.8	2.0	-0.5	-0.8	-0.2	0.5	1.2	-0.8	0.5	-1.4	-1.1
Bone: maximum force	0.4	0.8	3.2	-1.1	0.4	0.6	-0.1	-0.0	-0.8	-0.3	-1.8	-1.1
Bone: maximum moment	0.3	0.5	2.4	-1.0	0.2	0.5	-0.0	0.1	-0.7	-0.1	-1.6	-0.9
Mean time between licks in bursts	0.1	0.3	0.8	-0.1	-0.7	-0.4	0.8	0.7	0.2	0.9	0.2	0.5
Mean num. licks in bursts	0.9	1.4	5.7	0.0	-0.8	-0.5	0.7	1.2	-0.5	0.0	-2.1	-2.4
Cd content in liver	0.8	0.9	3.5	-0.6	0.5	0.3	-0.6	-0.2	-0.8	-0.7	-1.9	-1.7
Co content in liver	0.5	0.6	1.4	0.6	-0.2	-0.7	0.9	0.8	0.5	0.3	-1.1	-1.2
Cu content in liver	0.0	0.0	0.1	-0.1	-0.0	0.3	-0.3	-0.1	-0.3	-0.3	-0.0	0.2
Fe content in liver	0.8	1.0	2.0	-1.4	1.3	1.1	-0.8	-1.2	-1.0	-0.7	-0.6	0.6
K content in liver	1.1	1.1	1.8	1.1	-0.9	-1.3	1.3	1.2	1.1	1.1	-0.1	0.0
Mg content in liver	0.8	0.9	1.5	-0.9	0.7	1.0	-0.9	-0.7	-1.0	-1.0	-1.2	-0.6
Mn content in liver	2.4	2.6	3.7	-1.9	1.9	1.7	-1.7	-1.7	-1.8	-1.7	-1.3	-0.3
Na content in liver	0.9	0.9	1.5	0.9	-1.0	-1.1	1.1	1.2	0.9	1.2	0.2	0.5
Rb content in liver	0.3	0.3	1.5	-0.2	-0.1	0.2	-0.1	0.2	-0.5	-0.3	-1.2	-0.9
Se content in liver	1.2	1.4	2.8	-1.2	1.7	1.2	-1.3	-1.3	-1.0	-1.3	-0.8	-0.2
Sr content in liver	0.2	0.2	0.5	-0.1	0.3	-0.7	0.5	0.1	0.4	0.7	-0.3	0.5
Zn content in liver	0.1	0.1	0.2	0.4	-0.4	0.1	-0.2	0.1	0.1	-0.2	-0.4	0.0
Bone: minimum diameter	3.0	5.5	9.7	-3.1	2.0	2.5	-2.1	-1.5	-2.8	-2.2	-2.8	-1.5
Time in familiar zone, hab. session 1	0.2	0.2	0.6	0.5	-0.5	0.1	-0.2	-0.4	0.1	-0.2	0.7	0.3
Time in novel zone, hab. session 1	1.1	1.1	2.3	0.5	-0.4	-1.3	1.4	1.5	1.0	1.2	-0.5	-1.1
Total zone transitions, hab. session 1	0.4	0.6	1.3	-0.2	1.1	0.5	-0.5	-1.1	0.0	-0.4	1.0	1.1
Total locomotion distance, hab. session 1	0.6	0.8	2.1	-0.8	0.9	0.6	-0.6	-1.2	-0.4	-0.2	1.1	1.5
Locomotion velocity, hab. session 1	0.8	1.2	2.9	-1.1	1.0	0.9	-1.0	-1.4	-0.8	-0.5	0.8	1.7
Time in familiar zone, hab. session 2	1.0	1.1	3.0	1.3	-1.7	-1.0	1.0	1.3	0.7	0.8	-0.1	-0.8
Time in novel zone, hab. session 2	0.1	0.1	0.6	-0.1	0.8	0.1	0.1	-0.2	0.3	-0.0	-0.0	0.2
Total zone transitions, hab. session 2	0.8	1.0	2.9	1.1	0.1	-0.6	0.6	-0.2	1.4	0.6	1.7	1.4
Total locomotion distance, hab. session 2	0.2	0.2	0.5	-0.0	0.6	0.4	-0.5	-0.7	0.0	-0.4	0.4	0.5
Locomotion velocity, hab. session 2	0.2	0.3	0.5	0.1	0.6	0.3	-0.3	-0.7	0.3	-0.3	0.7	0.7
Novel to familiar place preference ratio	0.4	0.5	1.2	-0.5	0.2	0.5	-0.7	-0.2	-0.9	-0.8	-0.7	-1.1
Novelty place preference	0.5	0.5	1.8	-0.5	0.2	0.4	-0.5	0.0	-0.8	-0.8	-1.0	-1.3
Time in novel zone, NPP test	0.6	0.6	1.9	-0.6	0.2	0.5	-0.6	-0.1	-0.9	-0.8	-1.1	-1.4
Total zone transitions, NPP test	0.8	1.1	3.5	0.1	1.1	0.4	-0.3	-1.3	0.6	-0.2	1.9	1.7
Total locomotion distance, NPP test	1.3	1.8	3.9	-1.1	1.6	1.6	-1.5	-2.0	-0.8	-1.3	0.7	1.2
Locomotion velocity, NPP test	1.2	1.7	3.8	-1.0	1.6	1.5	-1.4	-1.9	-0.6	-1.2	0.8	1.2
Intraocular pressure	2.4	3.4	6.0	-1.6	2.2	1.8	-2.1	-2.4	-1.9	-2.4	-0.4	-0.7
Delta distance traveled before/after self-admin	1.4	1.5	2.8	1.0	-0.5	-1.7	1.6	1.1	1.6	1.6	0.6	0.3
Delta ambulatory time before/after self-admin	1.2	1.5	3.0	1.2	-0.3	-1.7	1.6	1.0	1.7	1.5	0.2	0.0
Parametrial fat weight	0.1	0.1	0.4	0.5	-0.4	-0.4	0.4	0.3	0.6	0.3	-0.1	-0.0
Pavlov. Cond. lever latency	0.5	0.6	1.3	-0.9	0.7	0.6	-0.7	-0.3	-0.8	-0.7	-1.1	-1.1
Pavlov. Cond. magazine entry latency	3.4	4.4	6.4	2.0	-1.8	-2.5	2.5	2.0	2.4	2.5	1.7	1.1
Pavlov. Cond. change in total contacts	0.7	0.7	1.5	0.6	-0.7	-1.2	1.2	1.1	0.7	1.1	0.1	0.2
Pavlov. Cond. index score	2.0	2.5	3.3	1.6	-1.5	-1.8	1.8	1.5	1.6	1.8	1.3	0.9
Pavlov. Cond. latency score	1.5	1.9	2.5	1.4	-1.5	-1.5	1.6	1.3	1.4	1.6	1.3	1.0
Pavlov. Cond. lever contacts	0.2	0.2	0.8	0.3	-0.3	-0.4	0.3	0.1	0.3	0.4	0.6	0.9
Pavlov. Cond. magazine entry number	5.4	6.9	10.7	-2.7	2.4	3.3	-3.2	-2.9	-2.9	-3.0	-1.4	-0.5
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.4	-0.9	1.2	1.0	-1.0	-1.0	-0.8	-0.9	-0.3	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.2	2.9	1.4	-1.3	-1.7	1.7	1.3	1.6	1.7	1.4	1.0
Pavlov. Cond. response bias	3.1	3.9	5.9	2.0	-1.7	-2.4	2.4	2.0	2.3	2.3	1.3	0.8
Pavlov. Cond. lever latency	0.3	0.3	1.3	0.3	-0.9	0.1	-0.0	0.3	-0.2	0.3	0.8	1.2
Pavlov. Cond. magazine entry latency	1.9	2.3	3.7	1.4	-1.1	-1.8	1.9	1.8	1.6	1.4	-0.8	-1.4
Pavlov. Cond. change in total contacts	0.2	0.3	0.9	-0.5	0.8	0.1	-0.1	-0.3	-0.0	-0.2	-1.0	-0.9
Pavlov. Cond. index score	0.6	0.8	2.5	0.4	0.1	-0.9	0.9	0.7	0.8	0.4	-1.1	-1.6
Pavlov. Cond. latency score	0.8	1.1	2.9	0.7	-0.2	-1.1	1.1	1.0	1.0	0.6	-1.0	-1.7
Pavlov. Cond. lever contacts	0.4	0.6	1.9	-0.4	1.1	0.1	-0.2	-0.5	0.0	-0.6	-1.1	-1.4
Pavlov. Cond. magazine entry number	1.2	1.5	3.3	-0.8	0.8	1.2	-1.3	-1.5	-0.9	-0.9	1.2	1.8
Pavlov. Cond. intertrial magazine entries	0.4	0.6	0.9	-0.9	0.4	0.7	-1.0	-0.7	-0.9	-0.5	0.6	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	3.1	0.5	0.1	-0.8	0.9	0.8	0.8	0.4	-1.3	-1.7
Pavlov. Cond. response bias	0.4	0.5	2.0	-0.3	0.6	-0.2	0.1	0.1	0.1	-0.2	-1.3	-1.4
Time in closed arm before self-admin	0.6	0.8	2.4	-1.3	1.6	0.7	-0.7	-1.2	-0.3	-0.4	0.2	0.8
Time in closed arm after self-admin	1.1	1.2	1.9	-1.2	1.0	1.2	-1.3	-1.4	-1.2	-1.0	0.2	0.6
Time in open arm before self-admin	2.6	2.9	5.4	2.3	-2.3	-1.7	1.7	1.7	1.5	1.7	1.1	0.5
Time in open arm after self-admin	2.2	2.5	5.2	2.0	-0.9	-1.9	1.9	1.5	2.3	1.4	-0.1	-0.9
Bone: periosteal estimation	0.4	0.9	3.4	-1.4	0.1	0.6	-0.2	0.2	-1.3	-0.3	-1.8	-1.0
Bone: periosteal perimeter	0.7	1.2	3.8	-1.6	-0.1	0.6	-0.3	0.4	-1.8	-0.3	-1.9	-1.0
Bone: post-yield work	0.3	0.4	0.9	0.2	-0.4	-0.7	0.9	0.6	0.4	0.9	0.2	0.6
Progressive ratio test 1 active lever presses	0.2	0.3	1.0	1.0	-0.6	-0.3	0.2	0.4	0.6	0.3	0.4	0.5
Progressive ratio test 1 breakpoint	0.2	0.2	0.8	0.9	-0.5	-0.2	0.1	0.4	0.4	0.2	0.3	0.5
Progressive ratio test 1 inactive lever presses	0.2	0.3	1.2	0.7	-0.3	-0.1	0.1	0.2	0.2	0.2	0.9	1.1
Progressive ratio test 2 active lever presses	0.9	1.1	2.6	1.6	-1.2	-0.9	1.0	1.2	1.3	0.9	-0.6	-0.1
Progressive ratio test 2 breakpoint	0.8	0.9	2.4	1.5	-1.0	-0.8	0.9	1.0	1.3	0.8	-0.5	-0.1
Progressive ratio test 2 inactive lever presses	0.3	0.5	1.0	0.9	-0.8	-0.5	0.6	1.0	0.7	0.6	-0.4	-0.1
Incentive Sensitization - Responses	1.2	1.7	3.0	1.3	-0.7	-1.5	1.6	1.6	1.7	1.4	-0.4	-0.7
Incentive Sensitization - Breakpoint	1.2	1.6	3.1	1.3	-0.7	-1.4	1.6	1.5	1.8	1.3	-0.3	-0.6
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	0.4	-0.4	-0.2	0.4	0.1	0.5	0.4	0.5	0.6
Progressive ratio	0.2	0.4	0.9	0.0	1.0	-0.5	0.4	0.1	0.8	0.3	-0.7	-0.8
Food seeking constrained by brief footshock	1.2	1.5	2.5	1.6	-0.7	-1.4	1.3	0.5	1.6	1.5	1.0	0.9
Seeking ratio, punishment vs. effort	0.5	0.7	2.0	0.8	-1.3	-0.5	0.5	0.2	0.2	0.6	1.4	1.1
Retroperitoneal fat weight	0.3	1.2	3.2	1.7	-0.7	-1.0	1.2	0.8	1.8	0.8	0.0	-0.5
Reaction time number correct	0.6	1.1	1.8	-0.8	1.2	1.1	-1.0	-1.1	-0.8	-1.3	-1.1	-0.6
Reaction time mean minus median	0.2	0.4	1.2	-0.4	1.0	0.7	-0.9	-1.1	-0.0	-0.6	0.5	-0.1
Reaction time mean minus median AUC	0.1	0.1	0.4	-0.0	0.4	0.3	-0.5	-0.6	0.2	-0.3	0.4	-0.3
Reaction time num false alarms	0.2	0.2	0.6	0.3	-0.7	-0.4	0.4	0.8	0.1	0.5	-0.2	-0.4
Reaction time num false alarms AUC	0.3	0.4	1.4	0.6	-1.2	-0.6	0.5	1.0	0.3	0.7	0.1	-0.1
Reaction time trials correct on left	0.6	1.1	1.8	-0.8	1.2	1.1	-1.0	-1.1	-0.8	-1.3	-1.1	-0.6
Reaction time trials on left	0.7	1.4	2.3	-0.9	1.4	1.3	-1.2	-1.2	-1.0	-1.5	-1.2	-0.7
Reaction time mean	2.3	3.6	5.0	-1.8	2.2	1.9	-2.1	-2.0	-1.5	-2.1	-1.7	-1.7
Reaction time mean AUC	1.7	2.7	3.8	-1.5	1.9	1.7	-1.9	-1.8	-1.2	-1.8	-1.3	-1.3
Median of all reaction times	2.4	3.4	4.0	-1.8	2.0	1.8	-1.9	-1.7	-1.5	-2.0	-2.0	-1.8
Reaction time omissions	3.1	4.6	7.5	-1.4	2.0	2.3	-2.2	-2.0	-1.8	-2.7	-1.9	-2.5
Reaction time false alarm rate	1.0	1.3	2.8	1.0	-1.7	-1.2	1.1	1.5	0.8	1.4	0.8	0.4
Reaction time premature initiation rate	3.0	4.1	5.9	2.2	-2.0	-2.3	2.0	1.9	2.3	2.4	1.8	0.7
Reaction time premature initiations	0.6	1.1	2.1	1.3	-0.9	-1.2	1.0	0.9	1.4	1.2	0.9	0.1
Std. dev. reaction times	1.0	1.8	3.6	-1.0	1.8	1.5	-1.7	-1.9	-0.7	-1.5	-0.2	-0.7
Reaction time trials completed	0.7	1.4	2.3	-0.9	1.4	1.3	-1.2	-1.2	-1.0	-1.5	-1.2	-0.7
Reaction time trials AUC	0.8	1.6	2.4	-1.0	1.4	1.3	-1.2	-1.2	-1.0	-1.6	-1.5	-1.0
Run reversals in cocaine runway, females	0.5	0.5	1.0	0.5	-0.8	0.7	-0.7	-0.7	-0.3	-0.3	0.6	1.0
Run reversals in cocaine runway, males	0.4	0.4	1.0	-0.4	-0.0	0.7	-0.5	-0.7	-0.4	-0.4	1.0	0.9
Latency to leave start box in cocaine runway	0.7	0.8	2.4	-0.9	0.9	0.3	-0.3	-0.6	-0.2	0.1	1.6	1.6
Latency to leave start box in cocaine runway, F	0.4	0.4	1.6	-0.6	0.5	-0.3	0.1	0.2	0.0	0.7	0.9	1.3
Latency to leave start box in cocaine runway, M	0.5	0.5	1.1	-0.4	0.4	0.7	-0.7	-1.1	-0.3	-0.6	0.9	0.7
Std. dev. time between licks in bursts	1.3	1.8	2.6	1.2	-1.4	-1.2	1.5	1.4	1.3	1.6	1.2	1.1
Total sessions with >9 infusions	0.5	0.6	2.3	1.5	-0.8	-0.4	0.4	0.3	0.8	0.4	0.7	0.6
Short access day 1 total inactive lever presses	0.3	0.3	1.2	1.1	-0.5	-0.2	0.3	0.2	0.8	0.3	0.2	0.8
Short access day 10 total inactive lever presses	0.3	0.7	2.2	-1.3	1.5	0.6	-0.6	-0.8	-0.4	-0.4	-0.0	1.0
Short access day 1 total infusions	0.3	0.4	1.5	0.9	-0.4	-0.2	0.1	0.1	0.6	0.2	1.2	1.0
Short access day 10 total infusions	0.2	0.3	0.4	0.6	-0.7	0.6	-0.6	-0.0	-0.4	-0.6	-0.5	-0.3
Short access total infusions	0.5	0.7	2.4	1.5	-0.9	-0.3	0.3	0.4	0.8	0.3	1.0	0.9
Short access day 1 locomotion	0.1	0.1	0.5	0.7	-0.5	0.1	-0.2	-0.0	-0.0	-0.2	-0.1	0.1
Short access day 10 total locomotion	2.4	4.5	7.8	-1.4	1.4	2.8	-2.8	-2.7	-2.2	-2.6	-1.5	0.1
Short access total locomotion	0.7	0.9	1.9	0.2	-0.3	1.3	-1.4	-1.1	-1.0	-1.2	-0.7	0.3
One hour access (0.3 mA shock)	0.5	0.6	1.7	1.3	-1.3	-0.4	0.4	0.8	0.8	0.4	-0.0	-0.0
Compulsive drug intake	0.5	0.7	2.8	0.2	0.6	-0.4	0.4	0.1	1.0	0.6	1.7	1.0
One hour access (shock baseline)	0.2	0.4	1.7	0.5	-0.9	0.1	-0.1	0.5	-0.1	-0.1	-1.3	-0.6
Social response proportion	6.1	6.9	10.8	-2.7	2.6	3.3	-3.2	-3.2	-2.7	-2.8	-0.3	0.9
Social responses	1.7	2.2	3.6	-1.3	1.5	1.8	-1.9	-1.7	-1.5	-1.8	-0.5	-0.2
Social time	0.4	0.6	1.6	-0.7	1.3	0.8	-0.8	-1.1	-0.5	-0.7	-0.3	0.3
Soleus weight	0.6	1.9	3.7	0.8	-1.6	-0.9	1.3	1.0	0.9	1.6	1.9	1.8
Bone: stiffness	0.4	0.6	2.4	-0.4	0.3	-0.2	0.5	0.6	0.1	0.2	-1.6	-1.3
Tibialis anterior weight	1.7	5.9	11.7	-2.4	2.6	3.1	-2.8	-3.4	-1.8	-2.5	0.5	1.4
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.4	-0.3	-0.1	0.2	0.5	-0.3	0.1	0.2	-0.2
Time to tail flick, vehicle, after self-admin	0.3	0.4	1.2	-0.2	-1.0	-0.1	0.2	1.1	-0.6	0.1	-0.8	-0.8
Time to tail flick, test, before self-admin	1.0	1.0	1.6	-0.4	0.5	1.2	-1.2	-0.9	-0.9	-1.2	-1.3	-1.0
Time to tail flick, test, after self-admin	0.9	0.9	1.6	-1.0	1.3	1.0	-0.9	-1.2	-0.6	-1.1	-0.7	-0.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.8	-0.0	-0.3	0.2	-0.1	0.2	-0.5	-0.4	-0.9	-0.6
Delta time to tail flick, test, before/after SA	0.3	0.3	1.0	-0.6	0.5	-0.1	0.2	-0.2	0.1	0.2	0.9	1.0
Tibia length	0.1	0.4	1.3	-0.3	-0.5	-0.3	0.5	0.7	-0.1	0.6	-1.2	-0.5
Ambulatory time before self-admin	0.2	0.3	0.9	0.9	-0.9	-0.2	0.2	0.4	0.4	0.3	0.8	0.1
Ambulatory time after self-admin	0.8	1.0	1.7	1.1	-0.5	-1.3	1.2	0.8	1.3	1.2	0.6	-0.1
Bone: tissue strength	0.4	0.4	0.9	-0.9	0.4	0.5	-0.2	-0.2	-0.7	-0.3	-0.9	-0.8
Total heroin consumption	0.6	0.7	1.6	-1.3	0.6	0.8	-0.9	-0.6	-1.2	-0.5	-0.9	0.1
Bone: trabecular number	0.0	0.1	0.1	-0.0	0.1	-0.3	0.3	0.2	0.4	0.3	0.1	0.1
Bone: trabecular spacing	1.2	1.6	2.1	-1.2	1.2	1.2	-1.2	-1.1	-1.4	-1.5	-1.3	-1.2
Bone: trabecular thickness	1.4	1.7	2.9	-1.7	1.3	1.4	-1.3	-1.6	-1.3	-0.9	-0.0	1.3
Bone: trabecular tissue density	0.2	0.3	1.1	0.5	0.7	0.4	-0.3	-1.0	0.4	-0.6	0.4	0.1
Water consumed over 24 hours	1.7	2.2	5.8	2.3	-0.9	-1.3	1.2	1.2	1.8	0.5	-0.6	-2.4
Number of responses in last shaping day	0.5	0.6	2.5	1.6	-1.2	-0.5	0.5	0.4	0.6	0.2	0.4	0.1